Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors

ABSTRACT

Embodiments concern methods and compositions for distinguishing benign from malignant thyroid tumor in a patient based on the expression levels of one or more miRNAs.

The application claims priority to U.S. Provisional Patent Application 61/552,451 filed on Oct. 27, 2011 and U.S. Provisional Patent Application 61/552,762 filed on Oct. 28, 2011, both of which are hereby incorporated by reference.

BACKGROUND OF THE INVENTION I. Field of the Invention

The invention relates generally to the field of molecular biology. More particularly, it concerns methods and compositions involving microRNA molecules (miRNAs). Certain aspects of the invention include applications for miRNAs in diagnostics, prognostics, and therapy for thyroid cancer.

II. Background

In 2001, several groups used a cloning method to isolate and identify a large group of “microRNAs” (miRNAs) from C. elegans, Drosophila, and humans (Lagos-Quintana et al., 2001; Lau et al., 2001; Lee and Ambros, 2001). Several hundreds of miRNAs have been identified in plants and animals—including humans—which do not appear to have endogenous siRNAs. Thus, while similar to siRNAs, miRNAs are nonetheless distinct.

miRNAs thus far observed have been approximately 21-22 nucleotides in length and arise from longer precursors, which are transcribed from non-protein-encoding genes. See review of Carrington et al. (2003). The precursors form structures that fold back on themselves in self-complementary regions; they are then processed by the nuclease Dicer in animals or DCL1 in plants. miRNA molecules interrupt translation through precise dr imprecise base-pairing with their targets.

Many miRNAs are conserved among diverse organisms, and this has led to the suggestion that miRNAs are involved in essential biological processes throughout the life span of an organism (Esquela-Keischer and Slack, 2006). In particular, miRNAs have been implicated in regulating cell growth and cell and tissue differentiation, cellular processes that are associated with the development of cancer. For instance, lin-4 and let-7 both regulate passage from one larval state to another during C. elegans development (Ambros, 2001). miR-14 and bantam are Drosophila miRNAs that regulate cell death, apparently by regulating the expression of genes involved in apoptosis (Brennecke et al., 2003, Xu et al., 2003).

Research on miRNAs is increasing as scientists are beginning to appreciate the broad role that these molecules play in the regulation of eukaryotic gene expression. In particular, several recent studies have shown that expression levels of numerous miRNAs are associated with various cancers (reviewed in Esquela-Kerscher and Slack, 2006). Reduced expression of two miRNAs correlates strongly with chronic lymphocytic leukemia in humans, providing a possible link between miRNAs and cancer (Calin et al., 2002). Others have evaluated the expression patterns of large numbers of miRNAs in multiple human cancers and observed differential expression of almost all miRNAs across numerous cancer types (Lu et al., 2005).

Thus, compelling evidence indicates that miRNAs play key roles in the development of many diseases and cancers, including thyroid cancer. Thyroid cancer is the fastest growing cancer diagnosis in the US with a total of 44,670 new cases and 1,690 deaths expected in 2010. From nuclear disasters such as Chemobyl in 1986, it is clear that radiation exposure is a significant risk factor for thyroid cancer but, the majority of thyroid cancers appear to be sporadic in nature. Thyroid cancers encompass a variety of lesions that range from benign adenoma to malignant tumors. They also span the spectrum from, well-differentiated, poorly differentiated or undifferentiated (anaplastic). More than 95% of thyroid cancers are derived from thyroid follicular cells, while 2-3% of thyroid tumors (medullary thyroid cancers) are derived from the calcitonin producing C-cells.

A number of genetic alterations have been shown to be involved in the development of follicular cell-derived cancers. These point mutations and translocations occur in genes for several important signaling pathways, in particular the mitogen-activated protein kinase (MAPK) pathway, and are required for transformation of well-differentiated follicular cell-derived thyroid cancers, i.e., papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC).

Asuragen miRInform Thyroid Panel Assay tests for the most common gene alterations identified in follicular cell-derived thyroid carcinomas. The panel consists of 7 genes that are either mutated (BRAF, NRAS, HRAS, KRAS) or rearranged by translocation (RET/PTC1, RET/PTC3, and PAXS/PPARγ). However, approximately 30% of thyroid cancers do not carry any known mutation and therefore cannot be identified using a test based on these markers only.

Methods and compositions that improve the ability to distinguish between benign thyroid conditions from malignant thyroid tumors, including mutation- and translocation-negative tumors.

SUMMARY OF THE INVENTION

Disclosed herein are methods and compositions for evaluating a thyroid sample from a patient to provide a clinician with information that is useful for determining diagnosis and/or treatment options. Methods involve obtaining information about the levels of expression of certain microRNAs or miRNAs whose expression levels differ between malignant and benign cells and tissue in the thyroid. In some embodiments, differences in miRNA expression between thyroid malignancies and benign thyroid cells and tissue are highlighted when expression level differences are first compared among two or more miRNAs and those differential values are compared to or contrasted with the differential values of malignant thyroid growths from non-malignant or benign thyroid growths. Such growths refer to abnormal growth of the thyroid and they include but are not limited to what are referred to as tumors, cysts, and modules.

Embodiments concern methods and compositions that can be used for evaluating a thyroid sample; categorizing a thyroid sample; evaluating a thyroid sample that has been tested for a mutation associated with malignancy; distinguishing a thyroid sample or growth; identifying a thyroid sample or growth as malignant; identifying a thyroid sample as benign; characterizing a BRAF V600E-negative thyroid sample or growth; characterizing a BRAF V600E-positive thyroid sample or growth; characterizing a thyroid sample or growth whose BRAF V600E status is not yet known; characterizing a thyroid sample or growth suspected of being malignant; characterizing a thyroid sample or growth that has already undergone a cytology or histology evaluation; testing a thyroid sample or growth known to be negative for mutations associated with thyroid malignancies; identifying thyroid tissue as a target for thyroidectomy; determining whether a. thyroid sample or growth is malignant; determining the thyroid should not be subject to a thyroidectomy; categorizing a thyroid tumor, cyst, or nodule; diagnosing a thyroid tumor, growth, or cyst; evaluating a recurrent thyroid tumor, growth or cyst; providing a prognosis to a patient regarding a thyroid tumor, growth or cyst; evaluating treatment options for a thyroid. sample suspected of being malignant; monitoring a patient's thyroid; or, treating a patient with malignant thyroid cancer. These methods can be implemented involving steps and compositions described below in different embodiments.

In some embodiments methods for evaluating a thyroid sample are provided in which methods involve measuring the level of expression of one or more miRNAs or the miRNA precursors, or one or more targets of the miRNA. In some embodiments, the thyroid sample has not been evaluated for any mutations associated with malignancy. In other embodiments, the thyroid sample has been tested for a BRAF V600E mutation. In certain cases, the thyroid sample from a patient has been determined to be negative for a BRAF V600E mutation. In further embodiments, the thyroid sample has been alternatively or additionally tested for a point mutation in one or more of the following; N-Ras, H-Ras or K-Ras and/or for the following genetic alterations: RET/PTC 1 (translocation), RET/PTC3 (translocation), and/or PAX8-PPARg Fusion Protein (PPFP) (translocaticn); these will be collectively referred to as mutations. In certain embodiments, a thyroid sample has been determined to be negative for a BRAF V600E mutation. In other embodiments, the thyroid sample has been determined to be negative for the following mutations: N-Ras, H-Ras, K-Ras, RET/PTC 1 (translocation), RET/PTC3 (translocation), PAX8-PPARg Fusion Protein (PPFP) (translocation). In further embodiments, however, a thyroid sample has been determined to be positive for a mutation related to thyroid malignancy, such as N-Ras, H-Ras, K-Ras, RET/PTC 1 (translocation), RET/PTC3 (translocation), PAX8-PPARg Fusion Protein (PPFP) (translocation). In some embodiments, a patient may be tested for a BRAF V600E mutation by having a thyroid sample assayed for miR-146b expression (Chou et al. 2010, which is hereby incorporated by reference).

In some embodiments, methods and steps discussed below are implemented on a thyroid sample that has been determined to be negative for a BRAF V600E mutation, to be positive for a mutation in N-Ras, H-Ras, K-Ras. RET/FTC 1 (translocation), RET/PTC3 (translocation), and/or PAX8-PPARg Fusion Protein (PPFP) (translocation), or to be negative for a mutation in BRAF V60E, N-Ras, H-Ras, K-Ras, RET/PTC 1 (translocation), RET/PTC3 (translocation), and PAX8-PPARg Fusion Protein (PPFP) (translocation), or to have an unknown mutation status related to BRAF V600E, N-Ras, H-Ras, K-Ras, RET/PTC 1 (translocation), RET/PTC3 (translocation), and PAX8-PPARg Fusion Protein (PPFP) (translocation). In some embodiments, methods include determining whether a thyroid sample has a BRAF V600E mutation. In even further embodiments, methods include assaying the sample for a BRAF V600E mutation. This assay may be performed before, after, or at the same time that the expression level of one or more miRNAs or other biomarkers is measured. Also, this assay may be performed before, after, or at the same time that a sample is assayed for a mutation in N-Ras, H-Ras, and/or K-Ras and/or for RET/PTC 1 (translocation), RET/PTC3 (translocation), and/or PAX8-PPARg Fusion Protein (PPFP) (translocation).

Methods for evaluating a. thyroid sample generally concern determining expression levels of one or more miRNAs because patterns of expression levels differ between malignant thyroid samples and benign thyroid samples. In some embodiments, methods are particularly valuable because they are able to distinguish malignant thyroid samples from benign thyroid samples when those samples were previously undistinguishable either from their pathology and/or from other genetic analysis. The sample may or may not have been evaluated by a cytology or histology to determine whether there were malignant cells present.

In some embodiments there are methods for evaluating a thyroid sample from a patient determined to be BRAF V600E-negative comprising a) measuring the level of expression of at least one biomarker miRNAs, wherein the biomarker is indicative of a thyroid malignancy; b) comparing the expression level of the at least one biomarker miRNA to the expression level of a comparative marker from the sample; and, c) evaluating the thyroid sample by calculating a score based on the compared expression levels, wherein the score indicates probability that the thyroid sample is benign or malignant.

Additional embodiments concern methods for determining whether a thyroid sample from a patient is malignant comprising: a) measuring expression levels of at least two differentially expressed diff pair miRNAs in the sample, wherein the expression of one miRNA is increased in a malignant thyroid sample relative to its level in a benign thyroid sample or other control and the expression of a second miRNA is decreased in malignant thyroid sample relative toils level in a benign thyroid sample or other control; b) calculating a diff pair value based on the expression levels of the increased miRNA and the decreased miRNA; and, c) evaluating the thyroid sample by calculating a score based on the compared expression levels, wherein the score indicates probability that the thyroid sample is benign or malignant.

In some embodiments there are methods for evaluating a thyroid sample from a patient comprising: a) measuring the level of expression of miR-375 or its precursor in the sample; b) comparing the expression level of miR-375 or its precursor in the sample to the level of expression of a first comparative miRNA; and, c) evaluating the sample based on the expression levels of miR-375, or its precursor and the comparative miRNA, wherein the evaluation assesses whether the sample comprises a malignant thyroid tumor. In some embodiments, methods further comprise measuring the level of expression of miR-34a-5p in the sample and comparing the miR-34a-5p expression level to the level of expression of the first or a second comparative miRNA. In additional embodiments, the first comparative miRNA is miR-7-5p. In particular embodiments, the sample's BRAF V600E mutation status has already been determined and known; in other embodiments, methods include determining whether the sample has a BRAF V600E mutation. In certain other embodiments, methods include assaying the sample for a BRAF V600E mutation.

Methods may involve measuring the level of expression of a biomarker miRNA. The term “biomarker miRNA” refers to a miRNA whose expression level is indicative of a particular disease or condition. In some embodiments the biomarker miRNA is one whose expression level is detectably increased in one population relative to another population, such as in malignancies compared to a benign thyroid growth. In other embodiments, a biomarker miRNA is one whose expression level is detectably decreased in one population relative to another population. A biomarker miRNA may be a diff pair miRNA. In certain embodiments. As part of a diff pair, the level of expression of a biomarker miRNA may highlight or emphasize differences in miRNA expression between different populations, such as a thyroid malignancy and a thyroid growth that is benign. In some embodiments, when miRNA expression is different in a particular population relative to another population, differences between miRNA expression levels can be increased, highlighted, emphasized, or otherwise more readily observed in the context of a diff pair. In some embodiments a biomarker miRNA is miR-10b, miR-15a, miR-21, miR-24-1-star, miR-24-2-star, miR-27a, miR-27b-star, miR-31, miR-31-star, miR-34a, miR-34a-star, miR-34b-star, miR-127-3p, miR-132, miR-132-star, miR-138-1-star, miR-140-5p, miR-142-5p, miR-146a, miR-146b-3p, miR-146b-5p, miR-155, miR-181a-star, miR-181c, miR-182, miR-196a, miR-205, miR-221, miR-221-star, miR-222, miR-222-star, miR-224, miR-301a, miR-329, miR-335, miR-340, miR-346, miR-369-5p, miR-375, miR-376c, miR-409-3p, milt-425, miR-493-star, miR-495, miR-539, miR-551b, miR-1827, miR-1910, miR-3065-5p, miR-3200-3p, and/or miR-4288. In further embodiments, a biomarker miRNA is measuring the level of expression of at least two of the following biomarker miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-81a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, and/or miR-182-5p. In certain embodiments, the first 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 or more (or any range derivable therein) or more of the miRNAs listed in the previous paragraph may be used in certain embodiments. In some embodiments a biomarker miRNA is one or more of the following: miR-10b, miR-15a, miR-21, miR-24-1-5p, miR-24-2-5p, miR-27a, miR-27b-5p, miR-31-5p, miR-31-3p, miR-34a-5p, miR-34a-3p, miR-34b-5p, miR-127-3p, miR-132-3p, miR-132-5p, miR-138-1-3p, miR-140-5p, miR-142-5p, miR-146a-5p, miR-146b-3p, miR-146b-5p, miR-155-5p, miR-181a-2-3p, miR-181c-5p, miR-182-5p, miR-196a-5p, miR-205-5p, miR-221-3p, miR-221-5p, miR-222-3p, miR-222-5p, miR-224-5p, miR-301a-3p, miR-329, miR-335-5p, miR-340-5p, miR-346, miR-369-5p, miR-375, miR-376c-3p, miR-409-3p, miR-425, miR-493-5p, miR-495-3p, miR-539-5p, miR-551b-3p, miR-1827, miR-1910, miR-3065-5p, miR-3200-3p, and/or miR-4288.

It is contemplated that in some embodiments 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38,39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 biomarker miRNAs (or any range derivable therein) may be measured. In some embodiments, a biomarker miRNA, is an miRNA listed in Table 1, 4D, or 5B. In other embodiments at least or at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 biomarker miRNAs are measured. In certain embodiments, any miRNA shown in Table 4A or 4B may be a biomarker or comparative miRNA. In further embodiments it is contemplated that a method or other embodiments may include at least or at most embodiments 1, 2, 3, 4, 5, 6, 7, 8, 9, 10; 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29. or 30 (or any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-46b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, and/or miR-182-5p. In specific embodiments, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or all 12 of the following miRNAs are included: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p; miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, and miR-15a-5p. In further embodiments, 1, 2, 3, 4, 5, 6, 7, 8, or all 9 (any any range derivable therein) of the following miRNAs are included additional or alternatively to the previous set: miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p. In additional embodiments, 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, or 12 (or any range derivable therein) of the following miRNAs may be included: miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, and miR-182-5p. In some cases, miR-224-5p and/or miR-222-5p may be included.

Measuring a microRNA or miRNA refers to measuring the amount of a mature microRNA or miRNA, though it is contemplated that a mature miRNA may be indirectly determined by measuring the level of an immature or unprocessed form of the miRNA, such as the double-stranded RNA molecule or RNA hairpin structure. Moreover, in some embodiments, the amount of a mature miRNA is determined by measuring the amount of one or more of the miRNA's target or the targets complement. An miRNA's target refers to the endogenous RNA in the thyroid cell that is the target for the miRNA and whose expression is affected by the miRNA. Consequently, any embodiments discussed herein in the context of determining the amount of a microRNA (i.e., the mature form of a microRNA) can be implemented instead by measuring a precursor of the miRNA or one or more of the miRNA's target (or the complement thereof). Unless qualified, the term “measuring” refers to directly measuring. Mature miRNAs may be indirectly determined by directly measuring precursor microRNA molecules. It will be understood that the term “star” in the context of a miR refers to an asterisk (*); for example, miR-222-star is the same as miR-222*.

Measuring or assaying for expression levels of a microRNA can be accomplished by a variety of different chemical and/or enzymatic reactions that are well known to those of skill in the art. In certain embodiments, methods may involve amplification and/or hybridization. It is contemplated that the level of a mature microRNA (miRNA) may be indirectly determined by measuring the level of the immature or unprocessed microRNA. Whether the mature or immature form of a microRNA is measured depends on the detection method, such as which primer or probe is used in the method. A person of ordinary skill in the art knows how this would be implemented.

Some methods also involve comparing the expression level of the at least one biomarker miRNA to the expression level of a comparative marker from the sample. In other embodiments, methods involve comparing the expression level of at least one biomarker miRNA to the expression level of that biomarker miRNA in a standardized sample, such as a sample known to be thyroid malignancy or known to be a benign thyroid condition. An increase or decrease in the level of expression will be evaluated. In some embodiments, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 comparative markers (or any range derivable therein) may be used in comparisons or compared to the expression level of a biomarker or of a biomarker miRNA. In other embodiments at least or at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 0.14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 comparative markers are measured. In particular embodiments, at least or at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 comparative markers are compared to one or more biomarker miRNAs. A “comparative marker” refers to a gene product (such as a protein, RNA transcript, miRNA, or unprocessed miRNA) whose expression level is used to evaluate the level of an miRNA in the sample; in some embodiments, the expression level of a comparative miRNA is used to evaluate a biomarker miRNA expression level. In specific embodiments, the comparative marker is an miRNA. Moreover, in certain embodiments, a comparative marker may also be a biomarker miRNA. In particular cases, a comparative marker is one whose expression level appears to change in the opposite direction as a biomarker miRNA against which it is compared. For example, a biomarker may have an increased expression level in a malignant thyroid sample as compared to a benign thyroid sample. The comparative marker that is used to compare against that biomarker may have a decreased expression level in a malignant thyroid sample as compared to a benign thyroid sample.

In some embodiments, the comparative marker is miR-7, miR-139-5p, miR-185-star, miR-486-5p, miR-519a, miR-1910, or miR-3123. In additional embodiments, a comparative miRNA is an miRNA listed in Table 1, 4D, or 5B. In further embodiments, a comparative marker is any of miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, and/or miR-182-5p.

Some methods involve measuring expression levels of at least two differentially expressed diff pair miRNAs in the sample, wherein the expression of one miRNA is increased in a malignant thyroid sample relative to a benign thyroid sample and the expression of a second miRNA is decreased in malignant thyroid sample relative to a benign thyroid sample. In some embodiments, the increased miRNA is miR-10b, miR-15a, miR-21, miR-24-1-star, miR-24-2-star, miR-27a, miR-27b-star, miR-31, miR-31-star, miR-34a, miR-34a-star, miR-34b-star, miR-127-3p, miR-132, miR-132-star, miR-138-1-star, miR-140-5p, miR-142-5p, miR-146a, miR-146b-3p, miR-146b-5p, miR-155, miR-181a-star, miR-181c, miR-182, miR-196a, miR-205, miR-221, miR-221-star, miR-222, miR-222-star, miR-224, miR-301a, miR-329, miR-335, miR-340, miR-346, miR-369-5p, miR-375, miR-376c, miR-409-3p, miR-425, miR-493-star, miR-495, miR-539, miR-551b, miR-1827, miR-1910, miR-3065-5p, miR-3200-3p, or miR-4288. It is contemplated that 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 of these increased miRNAs (or any range derivable therein) may be measured. In some embodiments, an increased miRNA is an miRNA listed in Tables 1, 4D, or 5B that shows a relative increase in expression. The term “diff pair miRNA” refers to a miRNA that is one member of a pair of miRNAs where the expression level of one miRNA of the diff pair in a sample is compared to the expression level of the other miRNA of the diff pair in the same sample. The expression levels of two diff pair miRNAs may be evaluated with respect to each other, i.e., compared, which includes but is not limited to subtracting, dividing, multiplying or adding values representing the expression levels of the two diff pair miRNAs. A. “diff pair” refers to the pair of diff pair miRNAs (or other marker). The diff pair is identified by an entity in front of a slash (/) and an entity following the slash. In embodiments described herein, the biomarker miRNA is understood as the entity in front of the slash and the comparative marker follows the slash. Moreover, it is readily apparent that the miRNA used as a biomarker and the miRNA used as the comparative miRNA may be switched, and that any calculated value can be evaluated accordingly by a person of ordinary skill in the art. However, a person of ordinary skill in the art understands that different pair analysis may be adjusted, particular with respect to altering the comparative miRNA in a pair without affecting the concept of the embodiments discussed herein.

In some embodiments it is specifically contemplated that the expression level of miR-467b in the sample is not measured. In other embodiments, the expression level of miR-221 and/or miR-222 in the sample is not measured. In further embodiments, they may be measured, but not to determine whether a sample is benign or malignant but for subclassifying a sample. In some embodiments, methods involve determining at least one diff pair value based on the expression levels of a diff pair, wherein the biomarker miRNA and a comparative marker are the diff pair. A differential pair value or diff pair value between the biomarker miRNA and the comparative marker can be calculated or determined or evaluated; this value is a number that is referred to as a “diff pair value” when it is based on the expression level of two miRNAs (or their precursors or targets). A diff pair value can be calculated, determined or evaluated using one or more mathematical formulas or algorithms. In some embodiments, the value is calculated, determined or evaluated using computer software. In particular embodiments, the diff pair is milt-375/miR-7. In other embodiments, the diff pair is miR-34a/miR-7 (miR-7 is synonymous with miR-7-5p). In additional embodiments a diff pair used in embodiments is 1, 2, 3, 4, 5, 6, 7, 8, or all 9 (and any range derivable therein) of the following diff pairs: miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/mir-7, and/or miR-146b-3p/miR-141-3p.

In some embodiments, a weighted coefficient may be applied to a diff pair value. In certain embodiments, a diff pair value for miR-375/miR-7-5p is weighted more heavily than a diff pair value for miR-34a/miR-7-5p. In other embodiments, a diff pair value for miR-34a/miR-7 is weighted more heavily than the diff pair value for miR-375/miR-7-5p. In some embodiments, the diff pair value for miR-375/miR-7-5p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p, miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-375/miR-204-5p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-375/miR-141-3p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-204-5p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-146b-5p/miR-7-5p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-miR-146b-5p/miR-204-5p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p, miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, miR-146b-3p/miR-7-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-146b-3p/miR-7-5p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p, miR-141-3p, miR-146b-3p/miR-204-5p, and/or miR-146b-3p/miR-141-3p. In some embodiments, the diff pair value for miR-146b-3p/miR-141-3p is weighted more heavily than a diff pair value for 1, 2, 3, 4, 5, 6, 7, or all 8 of miR-375/miR-7-5p, miR-375/miR-204-5p, miR-375/miR-141-3p, miR-146b-5p/miR-7-5p, miR-146b-5p/miR-204-5p, miR-146b-5p/miR-141-3p, miR-146b-3p/miR-204-5p, and/or miR-146b-3p/miR-7-5p.

Methods also include evaluating the thyroid sample by calculating a score based on the compared expression levels or diff pair values, wherein the score indicates probability that the thyroid sample is benign or malignant.

In certain embodiments, methods may involve classifying a sample as a hyperplastic nodule, follicular adenoma, oncocytic follicular adenoma, multi nodular goiter or Hashimoto's thyroiditis. In some cases, the sample is classified as a papillary carcinoma, follicular variant of papillary carcinoma, or a follicular carcinoma. The sample may be generally categorized as benign or malignant and subcategorized as one of the classifications discussed above. In certain embodiments, the categorization as benign or malignant occurs prior to subcategorization as one of the classifications, however, the testing for these may be done at the same (parallel) or different (serial) times. In some embodiments, miR-224-5p and/or miR-155-5p may be used for identifying Hashimoto's thyroiditis.

In other embodiments, a diff pair need not be evaluated and instead, a coefficient value is applied to each miRNA expression level. The coefficient value reflects the weight that the expression level of that particular miRNA has in assessing the chances that a particular pancreatic cyst is a high risk lesion or a low risk lesion. In some embodiments, instead of a diff pair value, a coefficient value is used for the measured expression level of miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-L-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and/or miR-182. In certain embodiments, the coefficient values for a plurality of miRNAs whose expression levels are measured add up to zero (0). The plurality may be, be at least, or be at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 of these miRNAs, as well as any miRNAs discussed herein. Methods and computer readable medium can be implemented with coefficient values instead of or in addition to diff pair values. In some cases, a coefficient may be multiplied against a diff pair value to reflect the weight of that diff pair in any analysis or diagnostic score calculation.

In some embodiments, the coefficient for miR-375 is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-146b-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-146b-5p is greater than or less than the coefficient for 1, 2, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-221-3p is greater than or less than. the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-222-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-18.1a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for mil-551b-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-81a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p miR-138-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-204-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 0.19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-7-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-141-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following mil RNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, mil-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments; the coefficient for miR-31-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any tango derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-22-3p is greater than or loss than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-38-1-3p miR-138-3p, miR-39-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-222-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-3p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-21-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-424-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-34a-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, mil-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-197-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-55.1 b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-81a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-19b-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p; miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-155-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-9b-3p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and/or miR-182: In other embodiments, the coefficient for miR-138-1-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19,20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-139-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-151a-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-29b-3p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, mil-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p; miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-96-5p is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-155a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-34a-star, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-34a-star is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-3065-5p, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-3065-5p is greater than or less than the coefficient for 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, mil-96-5p, miR-34a-star, miR-34b-star, and miR-182. In other embodiments, the coefficient for miR-34b-star is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-3.1-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, and miR-182. In other embodiments, the coefficient for miR-182 is greater than or less than the coefficient for 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or all 25 (any any range derivable therein) of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-151a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-star, miR-3065-5p, and miR-34b-star.

A difference between or among weighted coefficients may be, be at least or be at most 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6,0, 6,5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10.0, 10.5, 11.0, 11.5, 12.0, 12.5, 13.0, 13.5, 14.0, 14.5, 15.0, 15.5, 16.0, 16.5, 17.0, 17.5, 18.0, 18.5, 19.0, 19.5, 20.0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 305, 310, 315, 320, 325, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 385, 390, 395, 400, 410, 420, 425, 430, 440, 441, 450, 460, 470, 475, 480, 490, 500, 510, 520, 525, 530, 540, 550, 560, 570, 575, 580, 590, 600, 610, 620, 625, 630, 640, 650, 660, 670, 675, 680, 690, 700, 710, 720, 725, 730, 740, 750, 760, 770, 775, 780, 790, 800, 810, 820, 825, 830, 840, 850, 860, 870, 875, 880, 890, 900, 910, 920, 925, 930, 940, 950, 960, 970, 975, 980, 990, 1000 times or -fold (or any range derivable therein). Moreover, a person of ordinary skill in the art would understand that the coefficients could be negative or positive (in order to make their sum be zero, for example), but that the coefficient still reflected a difference in weight that is shown above.

In some embodiments, the accuracy of methods to determine whether a thyroid sample is benign or malignant or provide a diagnostic score is, is at least, or is at most 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, 99 or 100% (and any range derivable therein). In other embodiments, the accuracy of categorizing the sample. Into a subtype of benign or malignant conditions is, is at least, or is at most 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, 99 or 100% (and any range derivable therein).

Methods for treating a patient with thyroid cancer are also provided. In some embodiments such methods comprise; a) obtaining a diagnostic score based on expression levels of miRNAs in a thyroid sample from the patient, wherein the expression levels differ between malignant thyroid cancer cells compared to benign thyroid cells and wherein the thyroid sample has been determined to be negative for a BRAF V600E mutation; and, b) performing a thyroidectomy on a patient determined to have a diagnostic score indicative of malignant thyroid cancer.

In some embodiments, a patient is also administered radioactive iodine, radiation and/or chemotherapy as part of a treatment regimen. In further embodiments, methods may involve determining the patient as having or likely having a benign thyroid condition, or determining the patient as not having or likely not having a malignancy. In such cases, a clinician may then decide not to subject the patient to surgery. In such cases, the patient may continue to be monitored. In certain embodiments, methods involve imaging an unresected thyroid growth or doing a biopsy before and/or after miRNA levels are measured. In further embodiments, the imaging or biopsy occurs after 1, 2, 3, 4, 5, 6 months following a test that involves measuring one or more miRNA expression levels.

In some embodiments, methods will involve determining or calculating a diagnostic score based on data concerning the expression level of one or more miRNAs, meaning that the expression level of the one or more miRNAs is at least one of the factors on which the score is based. A diagnostic score will provide information about the biological sample, such as, the general probability that the thyroid sample is malignant and/or an aggressive tumor or that the thyroid sample is benign. In some embodiments, the diagnostic score represents the probability that the thyroid sample is more likely than not either malignant or benign. In certain embodiments, a probability value is expressed as a numerical integer or number that represents a probability of 0% likelihood to 100% likelihood that a patient has a thyroid malignancy or a benign thyroid condition. In some embodiments, the probability value is expressed as a numerical integer or number that represents a probability of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24,25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61,62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100% likelihood (or any range derivable therein) that a patient has a particular type of thyroid condition or growth. Alternatively, the probability may be expressed generally in percentiles, quartiles, or deciles.

In some embodiments, methods include evaluating one or more differential pair values using a scoring algorithm to generate a diagnostic score for the thyroid growth in terms of being malignant or being benign, wherein the patient is identified as having or as not having such a growth based on the score. It is understood by those of skill in the art that the score is a predictive value about the classification of the thyroid growth. In some embodiments, a report is generated and/or provided that identifies the diagnostic score or the values that factor into such a score. In some embodiments, a cut-off score is employed to characterize a sample as likely having a thyroid malignancy (or alternatively a benign thyroid condition). In some embodiments, the risk score for the patient is compared to a cut-off score to characterize the biological sample from the patient with respect to a malignancy or a benign condition. In certain embodiments, the diagnostic score is calculated using a weighted coefficient for each of the measured miRNA levels of expression. The weighted coefficients will typically reflect the significance of the expression level of a particular miRNA for determining risk of a certain disease state, such as malignancy or benign status, or any one of hyperplastic nodule, follicular adenoma, oncocytic follicular adenoma, multi nodular goiter, Hashimoto's thyroiditis, papillary carcinoma, follicular variant of papillary carcinoma, or a follicular carcinoma.

In some embodiments, determination of calculation of a diagnostic score is performed by applying classification algorithms based on the expression values of biomarkers with differential expression p values of about, between about, or at most about 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.011, 0.012, 0.013, 0.014, 0.015, 0.016, 0.017, 0.018, 0.019, 0.020, 0.021, 0.022, 0.023, 0.024, 0.025, 0.026, 0.027, 0.028, 0.029, 0.03, 0.031, 0.032, 0.033, 0.034, 0.035, 0.036, 0.037, 0.038, 0.039, 0.040, 0.041, 0.042, 0.043, 0.044, 0.045, 0.046, 0.047, 0.048, 0.049, 0.050, 0.051, 0.052, 0.053, 0.054, 0.055, 0.056, 0.057, 0:058, 0.059, 0.060, 0.061, 0.062, 0.063, 0.064, 0.065, 0.066, 0.067, 0.068, 0.069, 0.070, 0.071, 0:072, 0.073, 0.074, 0.075, 0.076, 0.077, 0.078, 0.079, 0.080, 0.081, 0.082, 0.083, 0.084, 0.085, 0.086, 0.087, 0.088, 0.089, 0.090, 0.091, 0.092, 0.093, 0.094, 0.095, 0.096, 0.097, 0.098, 0.099, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or higher (or any range derivable therein). In certain embodiments, the diagnostic score is calculated using one or more statistically significantly differentially expressed biomarkers (either individually or as diff pairs).

Methods may involve obtaining from the patient a thyroid sample, which means the sample is obtained directly from the patient. In other embodiments, a patient's thyroid tissue sample may be obtained from an entity that is not the patient, such as the doctor, clinician, hospital or laboratory. In certain embodiments, methods involve a thyroid tissue sample or a thyroid cyst or nodule sample. In particular embodiments, the sample is a tissue sample, while in other embodiments, the sample is a cystic fluid sample. In some cases, methods involve fixing the tissue sample in formalin and embedding it in paraffin prior to measuring the level of expression of one or more miRNAs or diff pair miRNAs in the sample. In additional embodiments, the sample is obtained by fine needle aspirate or FNA. In other embodiments, the sample is retrieved from a biopsy, such as a fine needle aspiration biopsy (FNAB) or a needle aspiration biopsy (NAB).

In some embodiments, a patient is determined to have a thyroid sample indicative of a malignancy or aggressive cancer. The term “indicative of a malignancy” means the data indicate that the patient likely has a malignancy, where “likely” means “greater than not.” In other embodiments, the patient is determined to have a thyroid sample indicative of a benign condition. The determination may or may not be based on a diagnostic score that is calculated based on one or more miRNA expression levels or diff pair values. In additional embodiments, methods involve determining a treatment for the patient based on one or more diff pair values. In some embodiments, methods include determining a treatment for the patient based on a calculated diagnostic score. In some embodiments, a patient may be suspected of having a thyroid malignancy. In other embodiments, the patient may have previously had a thyroid condition suspected of being malignant that was then subsequently treated. In. other embodiments, the patient has recurring thyroid growth, which may or may not be malignant. In still further embodiments, the patient has a familial history of thyroid growths, particularly malignant thyroid growths. In some circumstances, a patient also presents with symptoms of a thyroid growth, such as fatigue, change in appetite and other symptoms relating to a change in thyroid hormone levels.

Some embodiments further involve isolating ribonucleic or RNA from a biological sample. Other steps may or may not include amplifying a nucleic acid in a sample and/or hybridizing one or more probes to an amplified or non-amplified nucleic acid. In certain embodiments, a microarray may be used to measure or assay the level of miRNA expression in a sample.

The term “miRNA” is used according to its ordinary and plain meaning and refers to a microRNA molecule found in eukaryotes that is involved in RNA-based gene regulation. See, e.g., Carrington et al., 2003, which is hereby incorporated by reference. The term will be used to refer to the single-stranded RNA molecule processed from a precursor. Individual miRNAs have been identified and sequenced in different organisms, and they have been given names. Names of miRNAs that are related to the disclosed methods and compositions, as well as their sequences, are provided herein. The name of the miRNAs that are used in methods and compositions refers to an miRNA that is at least 90% identical to the named miRNA based on its mature sequence listed herein and that is capable of being detected under the conditions described herein using the designated ABI part number for the probe. In most embodiments, the sequence provided herein is the sequence that is being measured in methods described herein. In some methods, a step may involve using a nucleic acid with the sequence comprising or consisting of any of the complements of any of SEQ ID NOs:1-65 or any sequence found herein to measure expression of a miRNA in the sample. Alternatively, probes directed to the immature form of these miRNAs may be used, as may be probes directed to the targets of the miRNAs. In some embodiments, a complement of SEQ ID NO:1 (5′-GGAGAAAUUAUCCUUGGUGUGU′3′) is used to measure expression of naturally occurring miR-539 in a sample. In some embodiments, a complement of SEQ ID NO:2 (5′-UGGAAGACUAGUGAUUUUGUUGU′3′) is used to measure expression of naturally occurring miR-7-5p in a sample. In some embodiments, a complement of SEQ ID NO:3 (5′-UGAGAACUGAAUUCCAUAGGCU′3′) is used to measure expression of naturally occurring miR-146b-5p in a sample. In some embodiments, a complement of SEQ ID NO:4 (5′-UGCCCUGUGGACUCAGUUCUGG′3′) is used to measure expression of naturally occurring miR-146b-3p in a sample. In some embodiments, a complement of SEQ ID NO:5 (5′-AACACACCUGGUUAACCUCUUU′3′) is used to measure expression of naturally occurring miR-329 in a sample. In some embodiments, a complement of SEQ ID NO:6 (5′-UCGGAUCCGUCUGAGCUUGGCU′3′) is used to measure expression of naturally occurring miR-127-3p in a sample. In some embodiments, a complement of SEQ ID NO:7 (5′-ACCUGGCAUACAAUGUAGAUUU′3′) is used to measure expression of naturally occurring miR-221* in a sample. In some embodiments, a complement of SEQ ID NO:8 (5′-CCAGUCCUGUGCCUGCCGCCU′3′) is used to measure expression of naturally occurring miR-1910 in a sample. In some embodiments, a complement of SEQ ID NO:9 (5′-AAACAAACAUGGUGCACUUCUU′3′) is used to measure expression of naturally occurring miR-495 in a sample. In some embodiments, a complement of SEQ 1D NO:10 (5′-GAAUGUUGCUCGGUGAACCCCU′3′) is used to measure expression of naturally occurring miR-409-3p in a sample. In some embodiments, a complement of SEQ ID NO:11 (5′-AACAUAGAGGAAAUUCCACGU′3′) is used to measure expression of naturally occurring miR-376c in a sample. In some embodiments, a complement of SEQ ID NO:12 (5′-UCCUUCAUUCCACCGGAGUCUG′3′) is used to measure expression of naturally occurring miR-205 in a sample. In some embodiments, a complement of SEQ ID NO:13 (5′-UUUGUUCGUUCGGCUCGCGUGA′3′) is used to measure expression of naturally occurring miR-375 in a sample. In some embodiments, a complement of SEQ ID NO:14 (5′-CUCAGUAGCCAGUGUAGAUCCU′3′) is used to measure expression of naturally occurring miR-222* in a sample. In some embodiments, a complement of SEQ ID NO:15 (5′-AGAUCGACCGUGUUAUAUUCGC′3′) is used to measure expression of naturally occurring miR-369-5p in a sample. In some embodiments, a complement of SEQ ID NO:16 (5′-UGUCUGCCCGCAUGCCUGCCUCU′3′) is used to measure expression of naturally occurring miR-346 in a sample. In some embodiments, a complement of SEQ ID NO:17 (5′-AGCUACAUUGUCUGCUGGGUUUC′3′) is used to measure expression of naturally occurring miR-221 in a sample. In some embodiments, a complement of SEQ ID NO:18 (5′-AGGCAAGAUGCUGGCAUAGCU′3′) is used to measure expression of naturally occurring miR-31 in a sample. In some embodiments, a complement of SEQ ID NO:19 (5′-UUGUACAUGGUAGGCUUUCAUU′3′) is used to measure expression of naturally occurring miR-493* in a sample. In some embodiments, a complement of SEQ ID NO:21 (5′-CACCUUGCGCUACUCAGGUCUG′3′) is used to measure expression of naturally occurring miR-3200-3p in a sample. In some embodiments, a complement of SEQ ID NO:22 (5′-UAGCUUAUCAGACUGAUGUUGA′3′) is used to measure expression of naturally occurring miR-21 in a sample. In some embodiments, a complement of SEQ ID NO:23 (5′-UGGCAGUGUCUUAGCUGGUUGU′3′) is used to measure expression of naturally occurring miR-34a in a sample. In some embodiments, a complement of SEQ ID NO:24 (5′-GCUACUUCACAACACCAGGGCC′3′) is used to measure expression of naturally occurring miR-138-1* in a sample. In some embodiments, a complement of SEQ ID NO:25 (5′-UCUACAUACACUCACUGUCUCCAG′3′) is used to measure expression of naturally occurring miR-139-5p in a sample. In some embodiments, a complement of SEQ ID NO:26 (5′-UAACCACUGUCUGGUAAAGAUGG′3′) is used to measure expression of naturally occurring miR-141-3p in a sample. In some embodiments, a complement of SEQ ID NO:28 (5′-UUAAUGCUAAUCGUGAUAGGGGU′3′) is used to measure expression of naturally occurring miR-155 in a sample. In some embodiments, a complement of SEQ ID NO:30 (5′-UUCACCACCUUCUCCACCCAGC′3′) is used to measure expression of naturally occurring miR-197-3p in a sample. In some embodiments, a complement of SEQ ID NO:31 (5′-AGCUACAUCUGGCUACUGGGU′3′) is used to measure expression of naturally occurring miR-222 in a sample. In some embodiments, a complement of SEQ ID NO:32 (5′-CAAGUCACUAGUGGUUCCGUU′3′) is used to measure expression of naturally occurring miR-224 in a sample. In some embodiments, a complement of SEQ ID NO:33 (5′-AAUGACACGAUCACUCCCGUUGA′3′) is used to measure expression of naturally occurring miR-425 in a sample. In some embodiments, a complement of SEQ ID NO:34 (5′-UJAGAGAACUGAAUUCCAUGGGUU′3′) is used to measure expression of naturally occurring miR-146a in a sample. In some embodiments, a complement of SEQ ID NO:35 (5′-UACCCUGUAGAACCGAAUUUGUG′3′) is used to measure expression of naturally occurring miR-10b in a sample. In some embodiments, a complement of SEQ ID NO:36 (5′-UAGCAGCACAUAAUGGJUUULGUG′3′) is used to measure expression of naturally occurring miR-15a in a sample. In some embodiments, a complement of SEQ ID NO:37 (5′-UGCCUACUiAGCUGAUAUCAGU′3′) is used to measure expression of naturally occurring miR-24-1* in a sample. In some embodiments, a complement of SEQ ID NO:38 (5′-UGCCUACUGAGCUGAAACACAG′3′) is used to measure expression of naturally occurring miR-24-2* in a sample. In some embodiments, a complement of SEQ ID NO:39 (5′-LRICACAGUGGCUAAGUUCCGC′3′) is used to measure expression of naturally occurring miR-27a in a sample. In some embodiments, a complement of SEQ ID NO:40 (5′-AGAGCUUAGCUGAUUGGUGAAC′3′) is used to measure expression of naturally occurring miR-27b* in a sample. In some embodiments, a complement of SEQ ID NO:41 (5′-UGCUAUGCCAACAUAUUGCCAU′3′) is used to measure expression of naturally occurring miR-31* in a sample. In some embodiments, a complement of SEQ ID NO:42 (5′-CAAUCAGCAAGUAUACUGCCCU′3′) is used to measure expression of naturally occurring miR-34a* in a sample. In some embodiments, a complement of SEQ ID NO:43 (5′-UAGGCAGUGUCAUUAGCUGAUUG′3′) is used to measure expression of naturally occurring miR-34b* in a sample. In some embodiments, a complement of SEQ ID NO:44 (5′-UAACAGUCUACACCAGCCAUGGUCG′3′) is used to measure expression of naturally occurring miR-132 in a sample. In some embodiments, a complement of SEQ ID NO:45 (5′-ACCGUGGCUUUCGAUUGUUACU′3′) is used to measure expression of naturally occurring miR-132* in a sample. In some embodiments, a complement of SEQ ID NO:46 (5′-CAUAAAGUAGAAAGCACUACU′3′) is used to measure expression of naturally occurring miR-140-5p in a sample. In some embodiments, a complement of SEQ ID NO:47 (5′-ACCAUCGACCCJUUGAUUGUACC′3′) is used to measure expression of naturally occurring miR-181a* in a sample. In some embodiments, a complement of SEQ ID NO:48 (5′-AACAUUCAACCUGUCGGUGAGU′3′) is used to measure expression of naturally occurring miR-181c in a sample. In some embodiments, a complement of SEQ ID NO:49 (5′-UUUGGCAAUGGUAGAACUCACACU′3′) is used to measure expression of naturally occurring miR-182 in, a sample. In some embodiments, a complement of SEQ ID NO:50 (5′-UAGGUAGUUUCAUGUUGUUGGG′3′) is used to measure expression of naturally occurring milt-196a in a sample. In some embodiments, a complement of SEQ ID NO:51 (5′-CAGUGCAAUAGUAUUGUCAAAGC′3′) is used to measure expression of naturally occurring miR-301a in a sample. In some embodiments, a complement of SEQ ID NO:52 (5′-UCAAGAGCAAUAACOAAAAAUGU′3′) is used to measure expression of naturally occurring miR-335 in a sample. In some embodiments, a complement of SEQ ID NO:53 (5′-UUAUAAAGCAAUGAGACUGAUU′3′) is used to measure expression of naturally occurring miR-340 in a sample. In some embodiments, a complement of SEQ ID NO:54 (5′-GCGACCCAUACUUGGUUUCAG′3′) is used to measure expression of naturally occurring miR-551b in a sample. In some embodiments, a complement of SEQ ID NO:55 (5′-UGAGGCAGUAGAUUGAAU′3′) is used to measure expression of naturally occurring miR-1827 in a sample. In some embodiments, a complement of SEQ ID NO:56 (5′-UCAACAAAAUCACUGAUGCUGGA′3′) is used to measure expression of naturally occurring miR-3065-5p in a sample. In some embodiments, a complement of SEQ ID NO:57 (5′-UUGUCUGCUGAGUUUCC′3′) is used to measure expression of naturally occurring miR-4288 in a sample. In some embodiments, a complement of SEQ ID NO:63 (5′ CAUAAAGUAGAAAGCACUACU 3′) is used to measure expression of naturally occurring miR-142-5p in a sample. In some embodiments, a complement of SEQ ID NO:64 (5′-GUCCCUGUUCAGGCGCCA′3′) is used to measure expression of naturally occurring miR-1274a in a sample. In some embodiments, a complement of SEQ ID NO:90 (5′-UGUGCAAAUCCAUGCAAAACUGA′3′) is used to measure expression of naturally occurring miR-19b-3p in a sample. In some embodiments, a complement of SEQ ID NO:129 (5′-UUUGGCACUAGCACAUUUGCU′3′) is used to measure expression of naturally occurring miR-96-5p in a sample. In some embodiments, a complement of SEQ ID NO:139 (5′-UAGCACCAUUUGAAAUCAGUGUU′3′) is used to measure expression of naturally occurring miR-29b-3p in a sample. In some embodiments, a complement of SEQ ID NO:178 (5′-ACCACUGACCGUUGACUGUACC′3′) is used to measure expression of naturally occurring miR-181a-2-3p in a sample. In some embodiments, a complement of SEQ ID NO:192 (5′-UUCCCUUUGUCAUCCUAUGCCU′3′) is used. to measure expression of naturally occurring miR-204-5p in a sample. In some embodiments, a complement of SEQ ID NO:388 (5′-CUAGACUGAAGCUCCUUGAGG′3′) is used to measure expression of naturally occurring miR-151a-3p in a sample. In some embodiments, a complement of SEQ ID NO:413 (5′-CAGCAGCAAUUCAUGUUUUGAA′3′) is used to measure expression of naturally occurring miR-424-5p in a sample. It is contemplated that a probe used in methods may be 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, or 100% complementary (and any range derivable therein) to any of SEQ ID NOs:1-64 or any sequence found herein. Such probes may be 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 residues in length (or any range derivable therein).

ft is contemplated that the target of a miRNA may be measured as a surrogate of miRNA expression levels. For example, a target for miR-221 and miR-222 is CDKN1B (p27^(Kip1)).

Methods may also involve one or more of the following steps: obtaining a thyroid sample of a patient; preparing the sample to characterize miRNA in the sample (for instance, for hybridization and/or amplification); storing a sample from a patient; assessing the integrity or adequacy of the sample, such as of the nucleic acids; doing a cytology analysis of the sample; staining all or part of the sample using tissue stains; fixing all or part of the sample; freezing all or part of the sample; transporting the sample; providing or being provided one or more images of the sample; visually accessing the sample directly or remotely, such as with telemedicine; measuring the level of expression. of at least one biomarker miRNAs; comparing the level of expression of each biomarker miRNA to the level of expression of another biomarker miRNA; calculating a diagnostic score that indicates the probability the thyroid sample is benign or is malignant, wherein the diagnostic score is based on comparisons between the expression levels of the biomarker miRNAs to the expression level of at least one other biomarker miRNA; reporting the diagnostic score or the probability the thyroid sample is benign or malignant; storing information related to the expression levels of measured miRNA or related to comparisons between levels of miRNA or related to calculations from measured and/or compared expression levels or related to diagnostic scores; implementing an algorithm on a computer to calculate values that reflect comparisons between or among expression levels of biomarker miRNAs; implementing an algorithm on a computer to calculate diagnostic scores; diagnosing the patient as having or not having a thyroid malignancy; diagnosing the patient as having or not having a benign thyroid condition; categorizing a thyroid sample as a particular subtype or category of malignant thyroid conditions; categorizing a thyroid sample as a particular subtype or category of benign thyroid conditions; monitoring a patient's thyroid; and/or, treating the patient for a thyroid malignancy. It is contemplated that the score may indicate the probability that the sample is benign. In other embodiments, the score may indicate the probability that the sample is malignant. It will also be understood that a sample may be tested or evaluated more than one time either at the same time and/or at different times. In some cases, another test is run to obtain a second opinion on the same sample or a different sample from the patient.

Any of the methods described herein may be implemented on tangible computer-readable medium comprising computer-readable code that, when executed by a computer, causes the computer to perform one or more operations. In some embodiments, there is a tangible computer-readable medium comprising computer-readable code that, when executed by a computer, causes the computer to perform operations comprising: a) receiving information corresponding to a level of expression in a thyroid sample from a patient of at least two of the following diff pair miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-197a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, or miR-182-5p, wherein at least one of the miRNAs is a biomarker miRNA; and b) determining a biomarker diff pair value using information corresponding to the at least one biomarker miRNA and information corresponding to the level of expression of a comparative microRNA, the diff pair value being indicative of whether the thyroid growth is malignant or benign. In some embodiments, receiving information comprises receiving from a tangible data storage device information corresponding to a level of expression in a thyroid sample from a patient of at least two of the following diff pair miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-18.1a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, or miR-182-5p, wherein at least one of the miRNAs is a biomarker miRNA. In additional embodiments, information is used that corresponds to the level of expression of a comparative miRNA that is miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, or miR-182-5p. In additional embodiments the medium further comprises computer-readable code that, when executed by a computer, causes the computer to perform one or more additional operations comprising: sending information corresponding to the biomarker diff pair value to a tangible data storage device. In specific embodiments, it further comprises computer-readable code that, when executed by a computer, causes the computer to perform one or more additional operations comprising: sending information corresponding to the biomarker diff pair value to a tangible data storage device. In certain embodiments, receiving information comprises receiving from a tangible data storage device information corresponding to a level of expression in a thyroid sample from a patient of at least two of the following diff pair miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, or miR-182-5p, wherein at least one of the miRNAs is a biomarker miRNA. In even further embodiments, the tangible computer-readable medium has computer-readable code that, when executed by a computer, causes the computer to perform operations further comprising: c) calculating a diagnostic score for the thyroid sample, wherein the diagnostic score is indicative of the probability that the thyroid sample is malignant. it is contemplated that any of the methods described above may be implemented, with tangible computer readable medium that has computer readable code, that when executed by a computer, causes the computer to perform operations related to the measuring, comparing, and/or calculating a diagnostic score related to the probability of a malignancy or a benign thyroid condition.

A processor or processors can be used in performance of the operations driven by the example tangible computer-readable media disclosed herein. Alternatively, the processor or processors can perform those operations under hardware control, or under a combination of hardware and software control. For example, the processor may be a processor specifically configured to carry out one or more those operations, such as an application specific integrated circuit (ASIC) or a field programmable gate array (FPGA). The use of a processor or processors allows for the processing of information (e.g., data) that is not possible without the aid of a processor or processors, or at least not at the speed achievable with a processor or processors. Some embodiments of the performance of such operations may be achieved within a certain amount of time, such as an amount of time less than what it would take to perform the operations without the use of a computer system, processor, or processors, including no more than one hour, no more than 30 minutes, no more than 15 minutes, no more than 10 minutes, no more than one minute, no more than one second, and no more than every time interval in seconds between one second and one hour.

Some embodiments of the present tangible computer-readable media may be, for example, a CD-ROM, a DVD-ROM, a flash drive, a hard drive, or any other physical storage device. Some embodiments of the present methods may include recording a tangible computer-readable medium with computer-readable code that, when executed by a computer, causes the computer to perform any of the operations discussed herein, including those associated with the present tangible computer-readable media. Recording the tangible computer-readable medium may include, for example, burning data onto a CD-ROM or a DVD-ROM, or otherwise populating a physical storage device with the data.

Also provided are kits containing the disclosed compositions or compositions used to implement the disclosed methods. In some embodiments, kits can be used to evaluate one or more miRNA molecules. In certain embodiments, a kit contains, contains at least, or contains at most 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 or more, or any range and combination derivable therein, miRNA probes including those that may specifically hybridize under stringent conditions to miRNAs disclosed. herein. In other embodiments, kits or methods may involve 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 or more (or any range derivable therein) miRNA probes or corresponding primers, which may be capable of specifically detecting any of the following miRNAs: miR-375, miR-146b-3p, miR-146b-5p, miR-221-3p, miR-222-3p, miR-551b-3p, miR-204-5p, miR-7-5p, miR-141-3p, miR-31-5p, miR-181a-2-3p, miR-15a-5p, miR-224-5p, miR-221-5p, miR-222-5p, miR-21-5p, miR-424-5p, miR-34a-5p, miR-197-3p, miR-19b-3p, miR-155-5p, miR-138-1-3p, miR-139-5p, miR-151a-3p, miR-29b-3p, miR-96-5p, miR-34a-3p, miR-3065-5p, miR-34b-5p, miR-31-3p, miR-146a, miR-181c, or miR-182-5p.

The use of the word “a” or “an” when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.”

It is contemplated that any embodiment discussed herein can be implemented with respect to any disclosed method or composition, and vice versa. Any embodiment discussed with respect to a method can be implemented in the context of a kit or computer readable medium. Furthermore, the disclosed compositions and kits can be used to achieve the disclosed methods.

Throughout this application, the term “about” is used to indicate that a value includes the standard deviation of error for the device or method being employed to determine the value.

The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only, or the alternatives are mutually exclusive.

As used in this specification and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps. However, for a claim using any of these terms, embodiments are also contemplated where the claim is closed and does exclude additional, unrecited elements or method steps.

Other objects, features and advantages of the invention will be apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments, are given by way of illustration only, because various changes and modifications within the spirit and scope of the invention will be apparent to those skilled in the art from this detailed description.

DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and are included to further demonstrate certain aspects of the invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIGS. 1A, 1B and IC. Differentially expressed miRNAs identified from FFPE Samples. (A) 18 Differentially expressed miRs identified by LIMMA ANOVA analysis of Affymeirix miRNA array data (all significant at p<0.05 after Benjamini-Hochberg FDR adjustment). This analysis, in conjunction with pair-wise comparisons between different sample subgroups, led to the identification of a set of miRNAs for qRT-PCR Analysis. Good correlation was observed for benign-vs-malignant fold changes (shown as log-ratios for array and delta-Ct for PCR) between the array data and the PCR data for selected miRNA chosen for assay in FNA set 1 (B) and FNA set 2 (C). B=benign conditions other than FA.

FIGS. 2A and 2B, miRNA Expression in FNA Specimens correlated with mutational status. Principal Components Analysis (PCA) applied to qRT-PCR data (raw Ct values) derived from (A) PNA set 1 and (B) FNA set 2. Both sets show clear separation of BRAF-mutation positive samples from benign, less separation between mutation-negative malignant samples and benign samples. B_neg=benign, mutation-negative; M_BRAF=malignant, V600E mutation-positive; M_RAS=malignant, RAS mutation-positive; M_neg=malignant, mutation-negative.

FIG. 3. Preliminary Logistic Regression Classifier for FNA Samples, miR-146b and miR-222 show strongly differential expression between BRAF WT and mutant populations, but are much less useful for distinguishing mutation negative malignant from benign specimens.

FIGS. 4A, 4B and 4C. Strongest miRNA signals in miRNAs correlate with BRAF status. Logistic model fit to merged FNA set (using 11 miRNA, species assayed on both FNA sets). Model was fit using λ₁ penalized regression to DiffPaired data. The performance of this model was assessed using 5-fold cross-validation, with resulting malignancy predictions shown in (A) and resulting ROC curve shown in (B). Four DiffPairs received non-zero weights in final model, with the top two DiffPairs (values shown in (C)) having >5-fold larger weights than the bottom two.

FIG. 5. Algorithm describing the approach for modeling the distinction between benign and malignant FNA samples.

FIG. 6. LOOCV classification scores produced separating Hashimoto's disease samples from other thyroid samples.

FIG. 7. LOOCV classification scores produced by 5-miRNA model.

FIG. 8. LOOCV classification scores produced by 10-miRNA model.

DETAILED DESCRIPTION OF THE INVENTION

Certain embodiments are directed to compositions and methods relating to preparation and characterization of miRNAs, as well as use of miRNAs for prognostic and diagnostic applications, particularly those methods and compositions related to assessing and/or identifying thyroid cancer.

Histological subtypes of thyroid cancers have distinct miRNA expression profiles, and recent studies have suggested that miRNAs may be used in preoperative FNA samples to distinguish between hyperplastic thyroid nodules and malignant thyroid tumors. The use of miRNAs, as described herein, will complement and improve the performance (sensitivity and NPV) of the mutation Panel assay and allow the accurate classification of malignant FNAs, including those that are mutation-negative.

I. miRNA MOLECULES

MicroRNA molecules (“miRNAs”) are generally 21 to 22 nucleotides in length, though lengths of 19 and up to 23 nucleotides have been reported. The miRNAs are each processed from a longer precursor RNA molecule (“precursor miRNA”). Precursor miRNAs are transcribed from non-protein-encoding genes. The precursor miRNAs have two regions of complementarity that enable them to form a stem-loop- or fold-back-like structure, which is cleaved in animals by a ribonuclease Ill-like nuclease enzyme called Dicer. The processed miRNA is typically a portion of the stem.

The processed miRNA (also referred to as “mature miRNA”) becomes part of a large complex to down-regulate a particular target gene. Examples of animal miRNAs include those that imperfectly basepair with the target, which halls translation of the target (Olsen et al., 1999; Seggerson et al., 2002). siRNA molecules also are processed by Dicer, but from a long, double-stranded RNA. molecule. siRNAs are not naturally found in animal cells, but they can direct the sequence-specific cleavage of an mRNA target through an RNA-induced silencing complex (RISC) (Denli et al., 2003). In some embodiments, the mature miRNAs may be any of the miRNAs listed in Table 1.

TABLE 1  SEQ ID miRNA Probe Sequence NO hsa-miR- GGAGAAAUUAUCCUUGGUGUGU SEQ ID  539 NO: 1 hsa-miR- UGGAAGACUAGUGAUUUUGUUGU SEQ ID  7 NO: 2 hsa-miR- UGAGAACUGAAUUCCAUAGGCU SEQ ID  146b-5p NO: 3 hsa-miR- UGCCCUGUGGACUCAGUUCUGG SEQ ID  146b-3p NO: 4 hsa-miR- AACACACCUGGUUAACCUCUUU SEQ ID  329 NO: 5 hsa-miR- UCGGAUCCGUCUGAGCUUGGCU SEQ ID  127-3p NO: 6 hsa-miR- ACCUGGCAUACAAUGUAGAUUU SEQ ID  221* NO: 7 hsa-miR- CCAGUCCUGUGCCUGCCGCCU SEQ ID  1910 NO: 8 hsa-miR- AAACAAACAUGGUGCACUUCUU SEQ ID  495 NO: 9 hsa-miR- GAAUGUUGCUCGGUGAACCCCU SEQ ID  409-3p NO: 10 hsa-miR- AACAUAGAGGAAAUUCCACGU SEQ ID  376c NO: 11 hsa-miR- UCCUUCAUUCCACCGGAGUCUG SEQ ID  205 NO: 12 hsa-miR- UUUGUUCGUUCGGCUCGCGUGA SEQ ID  375 NO: 13 hsa-miR- CUCAGUAGCCAGUGUAGAUCCU SEQ ID  222* NO: 14 hsa-miR- AGAUCGACCGUGUUAUAUUCGC SEQ ID  369-5p NO: 15 hsa-miR- UGUCUGCCCGCAUGCCUGCCUCU SEQ ID  346 NO: 16 hsa-miR- AGCUACAUUGUCUGCUGGGUUUC SEQ ID  221 NO: 17 hsa-miR- AGGCAAGAUGCUGGCAUAGCU SEQ ID  31 NO: 18 hsa-miR- UUGUACAUGGUAGGCUUUCAUU SEQ ID  493* NO: 19 hsa-miR- AAUCUGAGAAGGCGCACAAGGU SEQ ID  3200-5p NO: 20 hsa-miR- CACCUUGCGCUACUCAGGUCUG SEQ ID  3200-3p NO: 21 hsa-miR- UAGCUUAUCAGACUGAUGUUGA SEQ ID  21 NO: 22 hsa-miR- UGGCAGUGUCUUAGCUGGUUGU SEQ ID  34a NO: 23 hsa-miR-  GCUACUUCACAACACCAGGGCC SEQ ID  138-1* NO: 24 hsa-miR-  UCUACAGUGCACGUGUCUCCAG SEQ ID  139-5p NO: 25 hsa-miR- UAACACUGUCUGGUAAAGAUGG SEQ ID  141 NO: 26 hsa-miR- GUCCAGUUUUCCCAGGAAUCCCU SEQ ID  145 NO: 27 hsa-miR- UUAAUGCUAAUCGUGAUAGGGGU SEQ ID  155 NO: 28 hsa-miR- UAUGGCACUGGUAGAAUUCACU SEQ ID  183 NO: 29 hsa-miR- UUCACCACCUUCUCCACCCAGC SEQ ID  197 NO: 30 hsa-miR- AGCUACAUCUGGCUACUGGGU SEQ ID  222 NO: 31 hsa-miR- CAAGUCACUAGUGGUUCCGUU SEQ ID  224 NO: 32 hsa-miR- AAUGACACGAUCACUCCCGUUGA SEQ ID  425 NO: 33 hsa-miR- UGAGAACUGAAUUCCAUGGGUU SEQ ID  146a NO: 34 hsa-miR- UACCCUGUAGAACCGAAUUUGUG SEQ ID  10b NO: 35 hsa-miR- UAGCAGCACAUAAUGGUUUGUG SEQ ID  15a NO: 36 hsa-miR- UGCCUACUGAGCUGAUAUCAGU SEQ ID  24-1* NO: 37 hsa-miR- UGCCUACUGAGCUGAAACACAG SEQ ID  24-2* NO: 38 hsa-miR- UUCACAGUGGCUAAGUUCCGC SEQ ID  27a NO: 39 hsa-miR- AGAGCUUAGCUGAUUGGUGAAC SEQ ID  27b* NO: 40 hsa-miR- UGCUAUGCCAACAUAUUGCCAU SEQ ID  31* NO: 41 hsa-miR- CAAUCAGCAAGUAUACUGCCCU SEQ ID  34a* NO: 42 hsa-miR- UAGGCAGUGUCAUUAGCUGAUUG SEQ ID  34b* NO: 43 hsa-miR- UAACAGUCUACAGCCAUGGUCG SEQ ID  132 NO: 44 hsa-miR- ACCGUGGCUUUCGAUUGUUACU SEQ ID  132* NO: 45 hsa-miR- CAUAAAGUAGAAAGCACUACU SEQ ID  140-5p NO: 46 hsa-miR- ACCAUCGACCGUUGAUUGUACC SEQ ID  181a NO: 47 hsa-miR- AACAUUCAACCUGUCGGUGAGU SEQ ID  181c NO: 48 hsa-miR- UUUGGCAAUGGUAGAACUCACACU SEQ ID  182 NO: 49 hsa-miR- UAGGUAGUUUCAUGUUGUUGGG SEQ ID  196a NO: 50 hsa-miR- CAGUGCAAUAGUAUUGUCAAAGC SEQ ID  301a NO: 51 hsa-miR- UCAAGAGCAAUAACGAAAAAUGU SEQ ID  335 NO: 52 hsa-miR- UUAUAAAGCAAUGAGACUGAUU SEQ ID  340 NO: 53 hsa-miR- GCGACCCAUACUUGGUUUCAG SEQ ID  551b NO: 54 hsa-miR- UGAGGCAGUAGAUUGAAU SEQ ID  1827 NO: 55 hsa-miR- UCAACAAAAUCACUGAUGCUGGA SEQ ID  3065-5p NO: 56 hsa-miR- UUGUCUGCUGAGUUUCC SEQ ID  4288 NO: 57 hsa-miR- AGGGGCUGGCUUUCCUCUGGUC SEQ ID  185* NO: 58 hsa-miR- CAGAGAAUUGUUUAAUC SEQ ID  3123 NO: 59 hsa-miR- CCAGUCCUGUGCCUGCCGCCU SEQ ID  1910 NO: 60 hsa-miR- UCCUGUACUGAGCUGCCCCGAG SEQ ID  486-5p NO: 61 hsa-miR- AAAGUGCAUCCUUUUAGAGUGU SEQ ID  519a NO: 62 hsa-miR- CAUAAAGUAGAAAGCACUACU SEQ ID  142-5p NO: 63 hsa-miR- GUCCCUGUUCAGGCGCCA SEQ ID  1274a NO: 64 hsa-miR- UGUGCAAAUCCAUGCAAAACUGA SEQ ID  19b-3p NO: 90 hsa-miR- UUUGGCACUAGCACAUUUUUGCU SEQ ID  96-5p NO: 129 hsa-miR- UAGCACCAUUUGAAAUCAGUGUU SEQ ID  29b-3p NO: 139 hsa-miR- ACCACUGACCGUUGACUGUACC SEQ ID  181a- NO: 178 2-3p hsa-miR- UUCCCUUUGUCAUCCUAUGCCU SEQ ID  204-5p NO: 192 hsa-miR-  CUAGACUGAAGCUCCUUGAGG SEQ ID  151a-3p NO: 388 hsa-miR- CAGCAGCAAUUCAUGUUUUGAA SEQ ID  424-5p NO: 413

A. Nucleic Acids

In the disclosed compositions and methods miRNAs can be labeled, used in. array analysis, or employed in diagnostic, therapeutic, or prognostic applications, particularly those related to pathological conditions of the thyroid. The RNA may have been endogenously produced by a cell, or been synthesized or produced chemically or recombinantly. They may be isolated and/or purified. The term “miRNA,” unless otherwise indicated, refers to the single-stranded processed RNA, after it has been cleaved from its precursor. The name of the miRNA is often abbreviated and referred to without a hsa-, mmu-, or mo-prefix and will be understood as such, depending on the context. Unless otherwise indicated, miRNAs referred to are human sequences identified as miR-X or let-X, where X is a number and/or letter.

In certain experiments, a miRNA probe designated by a suffix “5P” or “3P” can be used. “5P” indicates that the mature miRNA derives from the 5′ end of the precursor and a corresponding “3P” indicates that it derives from the 3′ end of the precursor, as described on the World Wide Web at sanger.ac.uk. Moreover, in some embodiments, a miRNA probe is used that does not correspond to a known human miRNA. It is contemplated that these non-human miRNA probes may be used in embodiments or that there may exist a human miRNA that is homologous to the non-human miRNA. While the methods and compositions are not limited to human miRNA, in certain embodiments, miRNA from human cells or a human biological sample is used or evaluated. In other embodiments, any mammalian miRNA or cell, biological sample, or preparation thereof may be employed.

In some embodiments, methods and compositions involving miRNA may concern miRNA and/or other nucleic acids. Nucleic acids may be, be at least, or be at most 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 0.19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56,57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72,73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 441, 450, 460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, or 1000 nucleotides, or any range derivable therein, in length. Such lengths cover the lengths of processed miRNA, miRNA probes, precursor miRNA, miRNA. containing vectors, control nucleic acids, and other probes and primers. In many embodiments, miRNAs are 19-24 nucleotides in length, while miRNA probes are 19-35 nucleotides in length, depending on the length of the processed miRNA and any flanking regions added. mRNA precursors are generally between 62 and 110 nucleotides in human s.

Nucleic acids used in methods and compositions disclosed herein may have regions of identity or complementarity to another nucleic acid. It is contemplated that the region of complementarity or identity can be at least 5 contiguous residues, though it is specifically contemplated that the region is, is at least, or is at most 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 441, 450, 460, 470, 480, 490, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, or 1000, or any range derivable therein, contiguous nucleotides from any nucleic acid discussed or provided herein, including any miR or precursor miR sequence. It is further understood that the length of complementarity within a precursor miRNA or between a miRNA probe and a miRNA or a miRNA gene are such lengths. Moreover, the complementarity may be expressed as a percentage, meaning that the complementarity between a probe and its target is 90% or greater over the length of the probe. In some embodiments, complementarity is or is at least 90%, 95% or 100%. In particular, such lengths may be applied to any nucleic acid comprising a nucleic acid sequence identified in any of the sequences disclosed herein. The commonly used name of the miRNA is given (with its identifying source in the prefix, for example, “hsa” for human sequences) and the processed miRNA sequence. Unless otherwise indicated, a miRNA without a prefix will be understood to refer to a human miRNA. A miRNA designated, for example, as miR-1-2 in the application will be understood to refer to hsa-miR-1-2. Moreover, a lowercase letter in the name of a miRNA may or may not be lowercase; for example, hsa-mir-130b can also be referred to as miR-130B. In addition, miRNA sequences with a “mu” or “mmu” sequence will be understood to refer to a mouse miRNA and miRNA sequences with a “mo” sequence will be understood to refer to a rat miRNA. The term “miRNA probe” refers to a nucleic acid probe that can identify a particular miRNA or structurally related miRNAs.

It is understood that a miRNA is derived from genomic sequences or a gene. In this respect, the term “gene” is used for simplicity to refer to the genomic sequence encoding the precursor miRNA for a given miRNA. However, embodiments may involve genomic sequences of a miRNA that are involved in its expression, such as a promoter or other regulatory sequences.

The term “recombinant” generally refers to a molecule that has been manipulated in vitro or that is a replicated or expressed product of such a molecule.

The term “nucleic acid” is well known in the art. A “nucleic acid” as used herein will generally refer to a molecule (one or more strands) of DNA, RNA or a derivative or analog thereof, comprising a nucleobase. A nucleobase includes, for example, a naturally occurring purine or pyrimidine base found in DNA (e.g., an adenine “A,” a guanine “G,” a thymine “T” or a cytosine “C”) or RNA (e.g., an A, a G, an uracil “U” or a C). The term “nucleic acid” encompasses the terms “oligonucleotide” and “polynucleotide,” each as a subgenus of the term “nucleic acid.”

The term “miRNA” generally refers to a single-stranded molecule, but in specific embodiments, molecules will also encompass a region or an additional strand that is partially (between 10 and 50% complementary across length of strand), substantially (greater than 50% but less than 100% complementary across length of strand) or fully complementary to another region of the same single-stranded molecule or to another nucleic acid. Thus, nucleic acids may encompass a molecule that comprises one or more complementary or self-complementary strand(s) or “complement(s)” of a particular sequence comprising a molecule. For example, precursor miRNA may have a self-complementary region, which is up to 100% complementary. miRNA probes or nucleic acids can include, can be, or can be at least 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, 99 or 100% complementary to their target.

As used herein, “hybridization”, “hybridizes” or “capable of hybridizing” is understood to mean the forming of a double or triple stranded molecule or a molecule with partial double or triple stranded nature. The term “anneal” is synonymous with “hybridize.” The term “hybridization”, “hybridize(s)” or “capable of hybridizing” encompasses the terms “stringent condition(s)” or “high stringency” and the terms “low stringency” or “low stringency condition(s).”

As used herein, “stringent condition(s)” or “high stringency” are those conditions that allow hybridization between or within one or more nucleic acid strand(s) containing complementary sequence(s), but preclude hybridization of random sequences. Stringent conditions tolerate little, if any, mismatch between a nucleic acid and a target strand. Such conditions are well known to those of ordinary skill in the art, and are preferred for applications requiring high selectivity. Non-limiting applications include isolating a nucleic acid, such as a gene or a nucleic acid segment thereof, or detecting at least one specific mRNA transcript or a nucleic acid segment thereof, and the like.

Stringent conditions may comprise low salt and/or high temperature conditions, such as provided by about 0.02 NM to about 0.5 M NaCl at temperatures of about 42° C. to about 70° C. It is understood that the temperature and ionic strength of a desired stringency are determined in part by the length of the particular nucleic acid(s), the length and nucleobase content of the target sequence(s), the charge composition of the nucleic acid(s), and to the presence or concentration of formamide, tetramethylammonium chloride or other solvent(s) in a hybridization mixture.

It is also understood that these ranges, compositions and conditions for hybridization are mentioned by way of non-limiting examples only, and that the desired stringency for a particular hybridization reaction is often determined empirically by comparison to one or more positive or negative controls. Depending on the application envisioned it is preferred to employ varying conditions of hybridization to achieve varying degrees of selectivity of a nucleic acid towards a target sequence. In a non-limiting example, identification or isolation of a related target nucleic acid that does not hybridize to a nucleic acid under stringent conditions may be achieved by hybridization at low temperature and/or high ionic strength. Such conditions are termed “low stringency” or “low stringency conditions,” and non-limiting examples of such include hybridization performed at about 0.15 M to about 0.9 M NaCl at a temperature range of about 20° C. to about 50° C. Of course, it is within the skill of one in the art to further modify the low or high stringency conditions to suite a particular application.

Embodiments may concern detecting miRNA expression levels through hybridization such as with probes. In other embodiments, expression levels may be determined using PCR, such as quantitative PCR. Primers to amplify target miRNA sequences (or corresponding cDNA sequences) may be employed in some embodiments.

Labeling methods and kits may use nucleotides that are both modified for attachment of a label and can be incorporated into a miRNA molecule. Such nucleotides include those that can be labeled with a dye, including a fluorescent dye, or with a molecule such as biotin. Labeled nucleotides are readily available; they can be acquired commercially or they can be synthesized by reactions known to those of skill in the art.

Modified nucleotides for use in the methods and compositions are not naturally occurring nucleotides, but instead, refer to prepared nucleotides that have a reactive moiety on them. Specific reactive functionalities of interest include: amino, sulfhydryl, sulfoxyl, aminosulthydryl, azido, epoxide, isothiocyanate, isocyanate, anhydride, monochlorotriazine, dichlorotriazine, mono- or dihalogen substituted pyridine, mono- or disubstituted diazine, maleimide, epoxide, aziridine, sulfonyl halide, acid halide, alkyl halide, aryl halide, alkylsulfonate, N-hydroxysuccinimide ester, imido ester, hydrazine, azidonitrophenyl, azide, 3-(2-pyridyl dithio)-propionamide; glyoxal, aldehyde, iodoacetyl, cyanomethyl ester, p-nitrophenyl. ester, o-nitrophenyl ester, hydroxypyridine ester, carbonyl imidazole, and other such chemical. groups. In some embodiments, the reactive functionality may be bonded directly to a nucleotide, or it may be bonded to the nucleotide through a linking group. The functional moiety and any linker cannot substantially impair the ability of the nucleotide to be added to the miRNA or to be labeled. Representative linking groups include carbon containing linking groups, typically ranging from about 2 to 18, usually from about 2 to 8 carbon atoms, where the carbon containing linking groups may or may not include one or more heteroatoms, e.g. S, O, N etc., and may or may not include one or more sites of unsaturation. Of particular interest in some embodiments are alkyl linking groups, typically lower alkyl linking groups of 1 to 16, usually 1 to 4 carbon atoms, where the linking groups may include one or more sites of unsaturation. The functionalized nucleotides (or primers) used in the above methods of functionalized target generation may be fabricated using known protocols or purchased from commercial vendors, e.g., Sigma, Roche, Ambion, etc. Functional groups may be prepared according to ways known to those of skill in the art, including the representative information found in U.S. Pat. Nos. 4,404,289; 4,405,711; 4,337,063 and 5,268,486, and U.K. Patent 1,529,202, which are all incorporated by reference.

Amine-modified nucleotides are used in some embodiments. The amine-modified nucleotide is a nucleotide that has a reactive amine group for attachment of the label. It is contemplated that any ribonucleotide (G, A, U, or C) or deoxyribonucleotide (G, A, T, or C) can be modified for labeling. Examples include, but are not limited to, the following modified ribo- and deoxyribo-nucleotides: 5-(3-aminoallyl)-UTP; 8-[(4-amino)butyl]-amino-ATP and 8-[(6-amnino)butyl]-amino-ATP; N6-(4-amino)butyl-ATP, N6-(6-amino)butyl-ATP, N4-[2,2-oxy-bis-(ethylamine)]-CTP; N6-(6-Amino)hexyl-ATP; 8-[(6-Amino)hexyl]-amino-ATP; 5-propargylamino-CTP, 5-propargylamino-UTP; 5-(3-aminoallyl)-dUTP; 8-[(4-amino)butyl]-amino-dATP and 8-[(6-amino)butyl]-amino-dATP; N6-(4-amino)butyl-dATP, N6-(6-amino)butyl-dATP, N4-[2,2-oxy-bis-(ethylamine)]-dCTP; N6-(6-Amino)hexyl-dATP; 8-[(6-Amino)hexyl]-amino-dATP; 5-propargylamino-dCTP, and 5-propargylamino-dUTP. Such nucleotides can be prepared according to methods known to those of skill in the art. Moreover, a person of ordinary skill in the art could prepare other nucleotide entities with the same amine-modification, such as a 5-(3-aminoallyl)-CTP, GTP, ATP, dCTP, dCTP, dTTP, or dUTP in place of a 5-(3-aminoallyl)-UTP.

B. Isolation of Nucleic Acids

Nucleic acids may be isolated using techniques well known to those of skill in the art, though in particular embodiments, methods for isolating small nucleic acid molecules, and/or isolating RNA molecules can be employed. Chromatography is a process often used to separate or isolate nucleic acids from protein or from other nucleic acids. Such methods can involve electrophoresis with a gel matrix, filter columns, alcohol precipitation, and/or other chromatography. If miRNA from cells is to be used or evaluated, methods generally involve lysing the cells with a chaotropic (e.g., guanidinium isothiocyanate) and/or detergent (e.g., N-lauroyl sarcosine) prior to implementing processes for isolating particular populations of RNA.

In particular methods for separating miRNA from other nucleic acids, a gel matrix is prepared using polyacrylamide, though agarose can also be used. The gels may be graded by concentration or they may be uniform. Plates or tubing can be used to hold the gel matrix for electrophoresis. Usually one-dimensional electrophoresis is employed for the separation of nucleic acids. Plates are used to prepare a slab gel, while the tubing (glass or rubber, typically) can be used to prepare a tube gel. The phrase “tube electrophoresis” refers to the use of a tube or tubing, instead of plates, to form the gel. Materials for implementing tube electrophoresis can be readily prepared by a person of skill in the art or purchased.

Methods may involve the use of organic solvents and/or alcohol to isolate nucleic acids, particularly miRNA used in methods and compositions disclosed herein. Some embodiments are described in U.S. patent application Ser. No. 10/667,126, which is hereby incorporated by reference. Generally, this disclosure provides methods for efficiently isolating small RNA molecules from cells comprising: adding an alcohol solution to a cell lysate and applying the alcohol/lysate mixture to a solid support before eluting the RNA molecules from the solid support. In some embodiments, the amount of alcohol added to a cell lysate achieves an alcohol concentration of about 55% to 60%. While different alcohols can be employed, ethanol works well. A solid support may be any structure, and it includes beads, filters, and columns, which may include a mineral or polymer support with electronegative groups. A glass fiber filter or column may work particularly well for such isolation procedures.

In specific embodiments, miRNA isolation processes include: a) lysing cells in the sample with a lysing solution comprising guanidinium, wherein a lysate with a concentration of at least about 1 M guanidinium is produced; b) extracting miRNA molecules from the lysate with an extraction solution comprising phenol; c) adding to the lysate an alcohol solution for forming a lysate/alcohol mixture, wherein the concentration of alcohol in the mixture is between about 35% to about 70%; d) applying the lysate/alcohol mixture to a solid support; e) eluting the miRNA molecules from the solid support with an ionic solution; and, 1) capturing the miRNA molecules. Typically the sample is dried down and resuspended in a liquid and volume appropriate for subsequent manipulation.

II. LABELS AND LABELING TECHNIQUES

In some embodiments, miRNAs are labeled. It is contemplated that miRNA may first be isolated and/or purified prior to labeling. This may achieve a reaction that more efficiently labels the miRNA, as opposed to other RNA in a sample in which the miRNA is not isolated or purified prior to labeling. In particular embodiments, the label is non-radioactive. Generally, nucleic acids may be labeled by adding labeled nucleotides (one-step process) or adding nucleotides and labeling the added nucleotides (two-step process).

A. Labeling Techniques

In some embodiments, nucleic acids are labeled by catalytically adding to the nucleic acid an already labeled nucleotide or nucleotides. One or more labeled nucleotides can be added to miRNA-molecules. See U.S. Pat. No. 6,723,509, which is hereby incorporated by reference.

In other embodiments, an unlabeled nucleotide(s) is catalytically added to a miRNA, and the unlabeled nucleotide is modified with a chemical moiety that enables it to be subsequently labeled. In some embodiments, the chemical moiety is a reactive amine such that the nucleotide is an amine-modified nucleotide. Examples of amine-modified nucleotides are well known to those of skill in the art, many being commercially available.

In contrast to labeling of cDNA during its synthesis, the issue for labeling miRNA is how to label the already existing molecule. Some aspects concern the use of an enzyme capable of using a di- or tri-phosphate ribonucleotide or deoxyribonucleotide as a substrate for its addition to a miRNA. Moreover, in specific embodiments, a modified di- or tri-phosphate ribonucleotide is added to the 3′ end of a miRNA. The source of the enzyme is not limiting. Examples of sources for the enzymes include yeast, gram-negative bacteria such as E. coli, Lactococcus lactis, and sheep pox virus.

Enzymes capable of adding such nucleotides include, but are not limited to, poly(A) polymerase, terminal transferase, and polynucleotide phosphorylase. In specific embodiments, a ligase is contemplated as not being the enzyme used to add the label, and instead, a non-ligase enzyme is employed.

Terminal transferase may catalyze the addition of nucleotides to the 3′ terminus of a nucleic acid. Polynucleotide phosphorylase can polymerize nucleotide diphosphates without the need for a primer.

B. Labels

Labels on miRNA or miRNA probes may be colorimetric (includes visible and UV spectrum, including fluorescent), luminescent, enzymatic, or positron emitting (including radioactive). The label may be detected directly or indirectly. Radioactive labels include ¹²⁵I, ³²P, ³³P, and ³⁵S. Examples of enzymatic labels include alkaline phosphatase, luciferase, horseradish peroxidase, and β-galactosidase. Labels can also be proteins with luminescent properties, e.g., green fluorescent protein and phicoerythrin.

The colorimetric and fluorescent labels contemplated for use as conjugates include, but are not limited to, Alexa Fluor dyes, BODIPY dyes, such as BODIPY FL; Cascade Blue: Cascade Yellow; coumarin and its derivatives, such as 7-amino-4-methylcoumiarin, aminocoumarin and hydroxycoumarin; cyanine dyes, such as Cy3 and Cy5; eosins and erythrosins; fluorescein and its derivatives, such as fluorescein isothiocyanate; macrocyclic chelates of lanthanide ions, such as Quantum Dyer™; Marina Blue; Oregon Green; rhodamine dyes, such as rhodamine red, tetramethylrhodamine and rhodamine 6G; Texas Red; fluorescent energy transfer dyes, such as thiazole orange-ethidium heterodimer; and, TOTAB.

Specific examples of dyes include, but are not limited to, those identified above and the following: Alexa Fluor 350, Alexa Fluor 405, Alexa Fluor 430, Alexa Fluor 488, Alexa Flour 500. Alexa Fluor 514, Alexa Fluor 532, Alexa Fluor 546, Alexa Fluor 555, Alexa Fluor 568, Alexa Fluor 594, Alexa Fluor 610, Alexa Fluor 633, Alexa Fluor 647, Alexa Fluor 660, Alexa Fluor 680, Alexa Fluor 700, and, Alexa Fluor 750; amine-reactive BODIPY dyes, such as BODIPY 493/503, BODIPY 530/550, BODIPY 558/568, BODIPY 564/570, BODIPY 576/589, BODIPY 581/591, BODIPY 630/650, BODIPY 650/655, BODIPY FL, BODIPY R6G, BODIPY TMR, and, BODIPY-TR; Cy3, Cy5, 6-FAM, Fluorescein Isothiocyanate, HEX, 6-JOE, Oregon Green 488, Oregon Green 500, Oregon Green 514, Pacific Blue, REG, Rhodamine Green, Rhodamine Red, Renographin, ROX, SYPRO, TAMRA, 2′,4′,5′,7′-Tetrabromosulfonefluorescein, and TET.

Specific examples of fluorescently labeled ribonucleotides include Alexa Fluor 488-5-UTP, Fluorescein-12-UTP, BODIPY FL-14-UTP, BODIPY TMR-14-UTP, Tetramethylrhodamine-6-UTP, Alexa Fluor 546-14-UTP, Texas Red-5-UCP, and BODIPY TR-14-UTP. Other fluorescent ribonucleotides include Cy3-UTP and Cy5-UTP.

Examples of fluorescently labeled deoxyribonucleotides include Dinitrophenyl (DNP)-11-dUTP, Cascade Blue-7-dUTP, Alexa Fluor 488-5-dUTP, Fluorescein-12-dUTP, Oregon Green 488-5-dUTP, BODIPY FL-14-dUTP, Rhodamine Green-5-dUTP, Alexa Fluor 532-5-dUTP, BODIPY TMR-14-dUTP, Tetramethylrhodamine-6-dUTP, Alexa Fluor 546-14-dUTP, Alexa Fluor 568-5-dUTP, Texas Red-12-dUTP, Texas Red-5-dUTP, BODIPY TR-14-dUTP, Alexa Fluor 594-5-dUTP, BODIPY 630/650-14-dUTP, BODIPY 650/665-14-dUTP; Alexa Fluor 488-7-OBEA-dCTP, Alexa Fluor 546-16-OBEA-dCTP, Alexa Fluor 594-7-OBEA-dCTP, and Alexa Fluor 647-12-OBEA-dCTP.

It is contemplated that nucleic acids may be labeled with two different labels. Furthermore, fluorescence resonance energy transfer (FRET) may be employed in disclosed methods (e.g., Klostermeier et al., 2002; Emptage, 2001; Didenko, 2001, each incorporated by reference).

Alternatively, the label, may not be detectable per se, but indirectly detectable or allowing for the isolation or separation of the targeted nucleic acid. For example, the label could be biotin, digoxigenin, polyvalent cations, chelator groups and other ligands, include ligands for an antibody.

C. Visualization Techniques

A number of techniques for visualizing or detecting labeled nucleic acids are readily available. Such techniques include, microscopy, arrays, fluorometry, light cyclers or other real time PCR machines, FACS analysis, scintillation counters, phosphoimagers, Geiger counters, MRI, CAT, antibody-based detection methods (Westerns, immunofluorescence, immunohistochemistry), histochemical techniques, HPLC (Griffey et al., 1997), spectroscopy, capillary gel electrophoresis (Cummins et al., 1996), spectroscopy; mass spectroscopy; radiological techniques; and mass balance techniques.

When two or more differentially colored labels are employed, fluorescent resonance energy transfer (FRET) techniques may be employed to characterize association of one or more nucleic acids. Furthermore, a person of ordinary skill in the art is well aware of ways of visualizing, identifying, and characterizing labeled nucleic acids, and accordingly, such protocols may be used. Examples of tools that may be used also include fluorescent microscopy, a BioAnalyzer, a plate reader, Storm (Molecular Dynamics), Array Scanner, FACS (fluorescent activated cell sorter), or any instrument that has the ability to excite and detect a fluorescent molecule.

III. ARRAY PREPARATION AND SCREENING

A. Array Preparation

Some embodiments involve the preparation and use of miRNA arrays or miRNA probe arrays, which are ordered macroarrays or microarrays of nucleic acid molecules (probes) that are fully or nearly complementary or identical to a plurality of miRNA molecules or precursor miRNA molecules and that are positioned on a support or support material in a spatially separated organization. Macroarrays are typically sheets of nitrocellulose or nylon upon which probes have been spotted. Microarrays position the nucleic acid probes more densely such that up to 10,000 nucleic acid molecules can be fit into a region typically 1 to 4 square centimeters. Microarrays can be fabricated by spotting nucleic acid molecules, e.g., genes, oligonucleotides, etc., onto substrates or fabricating oligonucleotide sequences in situ on a substrate. Spotted or fabricated nucleic acid molecules can be applied in a high density matrix pattern of up to about 30 non-identical nucleic acid molecules per square centimeter or higher, e.g. up to about 100 or even 1000 per square centimeter. Microarrays typically use coated glass as the solid support, in contrast to the nitrocellulose-based material of filter arrays. By having an ordered array of miRNA-complementing nucleic acid samples, the position of each sample can be tracked and linked to the original sample. A variety of different array devices in which a plurality of distinct nucleic acid probes are stably associated with the surface of a solid support are known to those of skill in the art. Useful substrates for arrays include nylon, glass, metal, plastic, and silicon. Such arrays may vary in a number of different ways, including average probe length, sequence or types of probes, nature of bond between the probe and the array surface, e.g. covalent or non-covalent, and the like. The labeling and screening methods are not limited by with respect to any parameter except that the probes detect miRNA; consequently, methods and compositions may be used with a variety of different types of miRNA. arrays.

Representative methods and apparatuses for preparing a microarray have been described, for example, in U.S. Pat. Nos. 5,143,854; 5,202,231; 5,242,974; 5,288,644; 5,324,633; 5,384,261; 5,405,783; 5,412,087; 5,424,186; 5,429,807; 5,432,049; 5,436,327; 5,445,934; 5,468,613; 5,470,710; 5,472,672; 5,492,806; 5,525,464; 5,503,980; 5,510,270; 5,525,464; 5,527,681; 5,529,756; 5,532,128; 5,545,531; 5,547,839; 5,554,501; 5,556,752; 5,561,071; 5,571,639; 5,580,726; 5,580,732; 5,593,839; 5,599,695; 5,599,672; 5,610,287; 5,624,711; 5,631,134; 5,639,603; 5,654,413; 5,658,734; 5,661,028; 5,665,547; 5,667,972; 5,695,940; 5,700,637; 5,744,305; 5,800,992; 5,807,522; 5,830,645; 5,837,196; 5,871,928; 5,847,219; 5,876,932; 5,919,626; 6,004,755; 6,087,102; 6,368,799; 6,383,749; 6,617,112; 6,638,717; 6,720,138, as well as WO 93/17126; WO 95/1995; WO 95/21265; WO 95/21944; WO 95/35505; WO 96/31622; WO 97/10365; WO 97/27317; WO 99/35505; WO 09923256; WO 09936760; WO0138580; WO 0168255; WO 03020898: WO 03040410; WO 03053586; WO 03087297; WO 03091426; WO03100012; WO 04020085; WO 04027093; EP 373 203; EP 785 280; EP 799 897 and UK 8 803 000, which are each herein incorporated by reference.

It is contemplated that the arrays can be high density arrays, such that they contain 2, 20, 25, 50, 80, 100, or more, or any integer derivable therein, different probes. It is contemplated that they may contain 1000, 16,000, 65,000, 250,000 or 1,000,000 or more, or any integer or range derivable therein, different probes. The probes can be directed to targets in one or more different organisms or cell types. In some embodiments, the oligonucleotide probes may range from 5 to 50, 5 to 45, 10 to 40, 9 to 34, or 15 to 40 nucleotides in length. In certain embodiments, the oligonucleotide probes are 5, 10, 15, 20, 25, 30, 35, 40 nucleotides in length, including all integers and ranges there between.

Moreover, the large number of different probes can occupy a relatively small area providing a high density array having a probe density of generally greater than about 60, 100, 600, 1000, 5,000, 10,000, 40,000, 100,000, or 400,000 different oligonucleotide probes per cm². The surface area of the array can be about or less than about 1, 1.6, 2, 3, 4, 5, 6, 7, 8, 9, or 10 cm².

Moreover, a person of ordinary skill in the art could readily analyze data generated using an array. Such protocols are disclosed herein or may be found in, for example, WO 9743450; WO 03023058; WO 03022421; WO 03029485; WO 03067217; WO 03066906; WO 03076928; WO 03093810; WO 03100448A1, all of which are specifically incorporated by reference.

B. Sample Preparation

It is contemplated that the miRNA of a wide variety of samples can be analyzed using arrays, miRNA probes, or array technology. While endogenous miRNA is contemplated for use with compositions and methods disclosed herein, recombinant miRNA—including nucleic acids that are complementary or identical to endogenous miRNA or precursor miRNA—can also be handled and analyzed as described herein. Samples may be biological samples, in which case, they can be from biopsy, fine needle aspirates, exfoliates, blood, tissue, organs, semen, saliva, tears, other bodily fluid, hair follicles, skin, or any sample containing or constituting biological cells. In certain embodiments, samples may be, but are not limited to, fresh, frozen, fixed, formalin fixed, paraffin embedded, or formalin fixed and paraffin embedded. Alternatively, the sample may not be a biological sample, but a chemical mixture, such as a cell-free reaction mixture (which may contain, one or more biological enzymes).

1. Biological Sample Collection

In certain aspects, methods involve obtaining a sample from a subject. The term subject may refer to an animal (for example a mammal), including but not limited to humans, non-human primates, rodents, dogs, or pigs. The methods of obtaining provided herein include methods of biopsy such as fine needle aspiration, core needle biopsy, vacuum assisted biopsy, incisional biopsy, excisional biopsy, punch biopsy, shave biopsy or skin biopsy: The sample may be obtained from any of the tissues provided herein that include but are not limited to gall bladder, skin, heart, lung, breast, pancreas, liver, muscle, kidney, smooth muscle, bladder, colon, intestine, brain, prostate, esophagus, or thyroid tissue. Alternatively, the sample may be obtained from any other source including but not limited to blood, sweat, hair follicle, buccal tissue, tears, menses, feces, or saliva. In certain aspects of the current methods, any medical professional such as a doctor, nurse or medical technician may obtain a biological sample for testing.

A sample may include but is not limited to, tissue, cells, or biological material from cells or derived from cells of a subject. The biological sample may be a heterogeneous or homogeneous population of cells or tissues. The biological sample may be obtained using any method known to the art that can provide a sample suitable for the analytical methods described herein. The sample may be obtained by non-invasive methods including but not limited to: scraping of the skin or cervix, swabbing of the cheek, saliva collection, urine collection, feces collection, collection of menses, tears, or semen.

The sample may be obtained by methods known in the art. In certain embodiments the samples are obtained by biopsy. In other embodiments the sample is obtained by swabbing, scraping, phlebotomy, or any other methods known in the art. In some cases, the sample may be obtained, stored, or transported using components of a kit of the present methods. In some cases, multiple samples, such as multiple thyroid samples may be obtained for diagnosis by the methods described herein. In other cases, multiple samples, such as one or more samples from one tissue type (for example thyroid) and one or more samples from another tissue (for example, buccal) may be obtained for diagnosis by the methods of the present methods. In some cases, multiple samples such as one or more samples from one tissue type (e.g., thyroid) and one or more samples from another tissue (e.g., buccal) may be obtained at the same or different times. Samples may be obtained at different times are stored and/or analyzed by different methods. For example, a sample may be obtained and analyzed by routine staining methods or any other cytological analysis methods.

In some cases, further samples may be obtained from a subject based on the results of such a cytological analysis. A cancer diagnosis may include an examination of a subject by a physician, nurse or other medical professional. The examination may be part of a routine examination, or the examination may be due to a specific complaint. A specific complaint may include but is not limited to: pain, illness, anticipation of illness, presence of a suspicious lump or mass, a disease, or a condition.

In some embodiments the subject may or may not be aware of the disease or condition.

In some cases, the subject may be referred to a specialist such as an oncologist, surgeon, or endocrinologist. The specialist may likewise obtain a biological sample for testing or refer the individual to a testing center or laboratory for submission of the biological sample. In some cases the medical professional may refer the subject to a testing center or laboratory for submission of the biological sample. In other cases, the subject may provide the sample. In some cases, a molecular profiling business may obtain the sample.

In some embodiments the biological sample may be obtained by a physician, nurse, or other medical professional such as a medical technician, endocrinologist, cytologist, phlebotomist, radiologist, or a pulmonologist. The medical professional may indicate the appropriate test or assay to perform on the sample. In certain aspects a molecular profiling business may consult on which assays or tests are most appropriately indicated.

In other cases, the sample is obtained by an invasive procedure including but not limited to: biopsy, alveolar or pulmonary lavage, needle aspiration, or phlebotomy. The method of needle aspiration may further include fine needle aspiration, core needle biopsy, vacuum assisted biopsy, or large core biopsy. In some embodiments, multiple samples may be obtained by the methods herein to ensure a sufficient amount of biological material. Methods of obtaining suitable samples of thyroid are known in the art and are further described in the ATA Guidelines for thyroid nodule management (Cooper et al. Thyroid Vol. 16 No. 2 2006), herein incorporated by reference in its entirety.

General methods for obtaining biological samples are also known in the art. Publications such as Ramzy, Ibrahim Clinical Cytopathology and Aspiration Biopsy 2001, which is herein incorporated by reference in its entirety, described general methods for biopsy and cytological methods. In one embodiment, the sample is a fine needle aspirate of a thyroid nodule or a suspected thyroid tumor. In some cases, the fine needle aspirate sampling procedure may be guided by the use of an ultrasound, X-ray, or other imaging device.

In some embodiments of the present methods, the molecular profiling business may obtain the biological sample from a subject directly, from a medical professional, from a third party, or from a kit provided by a molecular profiling business or a third party. In some cases, the biological sample may be obtained by the molecular profiling business after the subject, a medical professional, or a third party acquires and sends the biological sample to the molecular profiling business. In some cases, the molecular profiling business may provide suitable containers, and excipients for storage and transport of the biological sample to the molecular profiling business.

In some embodiments of the methods described. herein, a medical professional need not be involved in the initial diagnosis or sample acquisition. An individual may alternatively obtain a sample through the use of an over the counter (OTC) kit. An OTC kit may contain a means for obtaining said sample as described herein, a means for storing said sample for inspection, and instructions for proper use of the kit. In some cases, molecular profiling services are included in the price for purchase of the kit. In other cases, the molecular profiling services are billed separately. A sample suitable for use by the molecular profiling business may be any material containing tissues, cells, nucleic acids, genes, gene fragments, expression products, gene expression products, or gene expression product fragments of an individual to be tested. Methods for determining sample suitability and/or adequacy are provided.

2. Biological Sample Storage

In certain aspects, a sample may be obtained and prior to analysis by one or more methods described herein, the sample may be stored for a length of time. A length of time may include a time interval such as seconds, minutes, hours, days, weeks, months, years or longer. In some cases, the sample obtained from a subject is subdivided prior to the step of storage or further analysis. In some cases where the sample is subdivided different portions of the sample are subjected to different downstream methods or processes. Such methods or processes may include storage, cytological analysis, integrity tests, nucleic acid extraction, molecular profiling or any combination of these.

In some cases where storage is contemplated, some part of the sample may be stored while another portion of the sample is further processed. Processing may include but is not limited to molecular profiling, cytological staining, gene or gene expression product (RNA or protein) extraction, detection, or quantification, fixation or examination.

In other cases, the sample is obtained and stored and subdivided, after the step of storage for further analysis such that different portions of the sample are subject to different downstream methods or processes including but not limited to storage, cytological, analysis, adequacy tests, nucleic acid extraction, molecular profiling or a combination thereof.

In some cases, samples are obtained and analyzed by cytological analysis, and the resulting sample material is further analyzed by one, or more molecular profiling methods described herein. In such cases, the samples may be stored between the steps of cytological analysis and the steps of molecular profiling. Samples may be stored upon acquisition to facilitate transport, or to wait for the results of other analyses. In another embodiment, samples may be stored while awaiting instructions a medical professional.

An acquired sample may be placed in short term or long term storage by placing in a suitable medium, excipient, solution, or container. In certain cases storage may require keeping the sample in a refrigerated, or frozen environment. The sample may be quickly frozen prior to storage in a frozen environment. In certain instances the frozen sample may be contacted with a suitable cryopreservation medium or compound. Examples of cryopreservation mediums or compounds include but are not limited to: glycerol, ethylene glycol, sucrose, or glucose.

A suitable medium, excipient, or solution may include but is not limited to: hanks salt solution, saline, cellular growth medium, an ammonium salt solution such as ammonium sulphate or ammonium phosphate, or water.

Suitable concentrations of ammonium salts include solutions of about 0.1 g/ml, 0.2 g/ml, 0.3 g/ml, 0.4 g/ml, 0.5 g/ml, 0.6 g/ml, 0.7 g/ml, 0.8 g/ml, 0.9 g/ml, 1.0 g/ml, 1.1 g/ml, 1.2 g/ml, 1.3 g/ml, 1.4 g/ml, 1.5 g/ml, 1.6 g/ml, 1.7 g/ml, 1.8 g/ml, 1.9 g/ml, 2.0 g/ml, 2.2 g/ml, 2.3 g/ml, 2.5 g/ml, 2.7 g/ml, 3.0 g/ml or higher. The medium, excipient, or solution may or may not be sterile.

The medium, excipient, or solution may contain preservative agents to maintain the sample in an adequate state for subsequent diagnostics or manipulation, or to prevent coagulation. Said preservatives may include citrate, ethylene diamine tetraacetic acid, sodium azide, or thimerosol. The sample may be fixed prior to or during storage by any method known to the art such as using glutaraldehyde, formaldehyde, or methanol. The container may be any container suitable for storage and or transport of the biological sample including but not limited to: a cup, a cup with a lid, a tube, a sterile tube, a vacuum tube, a syringe, a bottle, a microscope slide, or any other suitable container. The container may or may not be sterile. In some cases, the sample may be stored in a commercial preparation suitable for storage of cells for subsequent cytological analysis such as but not limited to Cytyc ThinPrep, SurePath, or Monoprep.

The storage temperature may be explicitly defined or defined by a temperature range. The sample may be stored at room temperature or at reduced temperatures such as cold temperatures (e.g. between about 20° C. and about 0° C.), or freezing temperatures, including for example 0′C, −1° C., −2° C., −3° C., −4° C., −5° C., −6° C., −7° C., −8° C., −9° C., −10° C., −12° C., −14° C., −15° C., −16° C., −20° C., −22° C., −25° C., −28° C., −30° C., −35° C., −40° C., −45° C., −50° C., −60° C., −70° C., −80° C., −100° C., −120° C., −140° C., −180° C., −190° C., or about −200° C. The sample may be stored in any condition or environment that allows or achieves the desired. temperature condition. In some cases, the samples may be stored in a refrigerator, on ice or a frozen gel pack, in a freezer, in a cryogenic freezer, on dry ice, in liquid nitrogen, or in a vapor phase equilibrated with liquid nitrogen.

The sample container may be any container suitable for storage and or transport of the biological sample including but not limited to: a cup, a cup with a lid, a tube, a sterile tube, a vacuum tube, a syringe, a bottle, a microscope slide, or any other suitable container. The container may or may not be sterile.

3. Sample Conveyance and Transportation

Additionally contemplated in the current methods are methods of transporting a sample. Transport may involve moving or conveyance of a sample to or from a clinic, hospital, doctor's office, or other location to a second location. Upon transport the sample may be stored and/or analyzed by for example, cytological analysis or molecular profiling. In some embodiments some aspect of analysis, processing or profiling may begin or take place during transport. In some cases, the sample may be transported to a molecular profiling company in order to perform the analyses described herein. In other cases, the sample may be transported to a laboratory such as a laboratory authorized or otherwise capable of performing the methods described herein, such as a Clinical Laboratory improvement Amendments (CLIA) laboratory.

In some instances the subject may transport the sample. Transportation by an individual may include the individual appearing at a molecular profiling business or a designated sample receiving point and providing a sample. Providing of the sample may involve any of the techniques of sample acquisition described herein, or the sample may have already have been acquired and stored in a suitable container. In other cases the sample may be transported to a molecular profiling business using a courier service, the postal service, a shipping service, or any method capable of transporting the sample in a suitable manner.

In some cases, the sample may be provided to a molecular profiling business by a third party testing laboratory (e.g. a cytology lab). In other cases, the sample may be provided to a molecular profiling business by the subject's primary care physician, endocrinologist or other medical professional. The cost of transport may be billed to the individual, medical provider, or insurance provider. The molecular profiling business may begin analysis of the sample immediately upon receipt, or may store the sample in any manner described herein. The method of storage may or may not be the same as chosen prior to receipt of the sample by the molecular profiling business.

The sample may be transported in any medium or excipient including any medium or excipient provided herein suitable for storing the sample such as a cryopreservation medium or a liquid based cytology preparation. In some cases, the sample may be transported frozen refrigerated such as at any of the suitable sample storage temperatures provided herein.

Once the sample is received, the sample may be assayed using a variety of routine analyses known to the art such as cytological assays, and genomic analysis by a molecular profiling business, a representative or licensee thereof, a medical professional, researcher, or a third party laboratory or testing center (e.g. a cytology laboratory). Such tests may be indicative of cancer, the type of cancer, any other disease or condition, the presence of disease markers, or the absence of cancer, diseases, conditions, or disease markers. The tests may take the form of cytological examination including microscopic examination as described below. The tests may involve the use of one or more cytological stains. The biological material may be manipulated or prepared for the test prior to administration of the test by any suitable method known to the art for biological sample preparation. The specific assay performed may be determined by the molecular profiling company, the physician who ordered the test, or a third party such as a consulting medical professional, cytology laboratory, the subject from whom the sample derives, or an insurance provider. The specific assay may be chosen based on the likelihood of obtaining a definite diagnosis, the cost of the assay, the speed of the assay, or the suitability of the assay to the type of material provided.

4. Sample Integrity Tests

In some embodiments, concurrent with sample acquisition, sample storage or sample analysis the sample may be subjected to tests or examination that detail or reveal the integrity of the sample for use in the compositions or methods described herein. As a result of an integrity test a sample may be determined to be adequate or inadequate for further analysis.

In some embodiments sample integrity tests may pertain to the quality, integrity or adequacy of cells and or tissue in the sample. Metrics employed to determine quality, integrity or adequacy may involve but are not limited to cell number tests, cell viability tests, nuclear content tests, genetic content tests, biochemical assays, cell mass tests, cell volume tests, PCR tests, Q-PCR tests, RT-PCR tests, immunochemical analysis, histochemical analysis, microscopic analysis or visual analysis.

In certain aspects sample integrity may be ascertained by tests that measure nucleic acid content or integrity. Nucleic acid content tests may measure DNA content, RNA content or a some mixture of DNA or RNA. In some aspects nucleic acids are extracted or purified from other cellular components prior to a nucleic acid content test. In some embodiments nucleic acid specific dyes are used to assay nucleic acid integrity. In cases of nucleic acid extraction, spectrophotometric or electrophoretic methods may be used to assay nucleic acid integrity.

In yet other aspects, sample integrity may be ascertained by tests that measure protein content or integrity. Methods that measure protein content or integrity are well known to those skilled in the art. Such methods include but are not limited to ultraviolet absorbance reading (e.g. 280 nm absorbance readings), cell staining, protein staining or immunocytochemical methods. In some instances tests may be performed in parallel in intact samples or the samples may be divided and tests performed serially or in parallel.

Integrity tests may be performed on small subsets or aliquots of a sample or on the entirety of a sample.

C. Hybridization

After an array or a set of miRNA probes is prepared and the miRNA in the sample is labeled, the population of target nucleic acids is contacted with the array or probes under hybridization conditions, where such conditions can be adjusted, as desired, to provide for an optimum level of specificity in view of the particular assay being performed. Suitable hybridization, conditions are well known to those of skill in the art and reviewed in Sambrook et al. (2001) and WO 95/21944. Of particular interest in embodiments is the use of stringent conditions during hybridization. Stringent conditions are known to those of skill in the art.

It is specifically contemplated that a single array or set of probes may be contacted with multiple samples. The samples may be labeled with different labels to distinguish the samples. For example, a single array can be contacted with a tumor tissue sample labeled with Cy3, and normal tissue sample labeled with Cy5. Differences between the samples for particular miRNAs corresponding, to probes on the array can be readily ascertained and quantified.

The small surface area of the array permits uniform hybridization conditions, such as temperature regulation and salt content. Moreover, because of the small area occupied by the high density arrays, hybridization may be carried out in extremely small fluid volumes (e.g., about 250 μl or less, including volumes of about or less than about 5, 10, 25, 50, 60, 70, 80, 90, 100 μl, or any range derivable therein). In small volumes, hybridization may proceed very rapidly.

D. Differential Expression Analyses

Arrays can be used to detect differences between two samples. Specifically contemplated applications include identifying and/or quantifying differences between miRNA from a sample that is normal and from a sample that is not normal, between a cancerous condition and a non-cancerous condition, or between two differently treated samples. Also, miRNA may be compared between a sample believed to be susceptible to a particular disease or condition and one believed to be not susceptible or resistant to that disease or condition. A sample that is not normal is one exhibiting phenotypic trait(s) of a disease or condition or one believed to be not normal with respect to that disease or condition. It may be compared to a cell that is normal with respect to that disease or condition. Phenotypic traits include symptoms of, or susceptibility to, a disease or condition of which a component is or may or may not be genetic or caused by a hyperproliferative or neoplastic cell or cells.

An array comprises a solid support with nucleic acid probes attached to the support. Arrays typically comprise a plurality of different nucleic acid probes that are coupled to a surface of a substrate in different, known locations. These arrays, also described as “microarrays” or colloquially “chips” have been generally described in the art, for example, U.S. Pat. Nos. 5,143,854, 5,445,934, 5,744,305, 5,677,195, 6,040,193, 5,424,186 and Fodor et al., 1991), each of which is incorporated by reference in its entirety for all purposes. These arrays may generally be produced using mechanical synthesis methods or light directed synthesis methods that incorporate a combination of photolithographic methods and solid phase synthesis methods. Techniques for the synthesis of these arrays using mechanical synthesis methods are described in, e.g., U.S. Pat. No. 5,384,261, incorporated herein by reference in its entirety. Although a planar array surface is used ii certain aspects, the array may be fabricated on a surface of virtually any shape or even a multiplicity of surfaces. Arrays may be nucleic acids on beads, gels, polymeric surfaces, fibers such as fiber optics, glass or any other appropriate substrate (see U.S. Pat. Nos. 5,770,358, 5,789,162, 5,708,153, 6,040,193 and 5,800,992, each of which is hereby incorporated in its entirety). Arrays may be packaged in such a manner as to allow for diagnostics or other manipulation of an all inclusive device (see for example, U.S. Pat. Nos. 5,856,174 and 5,922,591, each incorporated in its entirety by reference). See also U.S. patent application Ser. No. 09/545,207, filed Apr. 7, 2000, which is incorporated by reference in its entirety for additional information concerning arrays, their manufacture, and their characteristics,

Particularly, arrays can be used to evaluate samples with respect to diseases or conditions that include, but are not limited to: benign thyroid conditions and malignant thyroid tumors, including mutation- and translocation-negative tumors.

Moreover, miRNAs can be evaluated with respect to the following diseases, conditions, and disorders: benign thyroid conditions and, malignant thyroid tumors, including mutation- and translocation-negative tumors; conventional follicular carcinomas (FC); oncocytic. follicular carcinomas (OFC); nodular hyperplasias (NH); follicular adenomas (FA); papillary carcinomas (PC). In addition, miRNAs can be evaluated with respect to thyroid tumors and the determination of whether a particular tumor is not generally malignant or aggressive. Also, miRNAs can be evaluated with respect to determining whether a particular tumor is generally considered malignant and/or aggressive.

It is specifically contemplated that the disclosed methods and compositions can be used to evaluate differences between stages of disease, such as between hyperplasia, neoplasia, pre-cancer and cancer, or between a primary tumor and a metastasized tumor, or between a lesion that is low risk (i.e., not generally malignant or aggressive) and a lesion that is high risk (i.e., generally considered malignant and/or aggressive).

E. Other Assays

In addition to the use of arrays and microarrays, it is contemplated that a number of different assays could be employed to analyze miRNAs, their activities, and their effects. Such assays include, but are not limited to, nucleic acid amplification, polymerase chain reaction, quantitative PCR, RT-PCR, in sire hybridization, Northern hybridization, hybridization protection assay (HPA), branched DNA (bDNA) assay, rolling circle amplification (RCA), single molecule hybridization detection, Invader assay, and/or Bridge Litigation Assay.

F. Evaluation of Expression Levels

A variety of different models can be employed to evaluate expression levels and/or other comparative values based on expression levels of miRNAs (or their precursors or targets). One model used in the Examples described below is a logistic regression model (see the Wikipedia entry on the World Wide Web at en.wikipedia, which is hereby incorporated by reference).

Start by computing the weighted sum of the DiffPair values:

z=β ₀+β₁* Diff(miR_(1a),miR_(1b))+β₂*Diff(miR_(2a),miR_(2b))+ . . .

where the β₀ is the (Intercept) term identified in the spreadsheets, while the remaining βi are the weights corresponding to the various DiffPairs in the model in question. Once z is computed, the score p_(alignment) (which may be interpreted as predicted probability of malignancy) is calculated as

$P_{malignant} = \frac{1}{1 + {\exp \left( {- z} \right)}}$

This functions to turn the number z, which may be any value from negative infinity to positive infinity, into a number between 0 and 1, with negative values for z becoming scores/probabilities of less than 50% and positive values for z becoming scores/probabilities of greater than 50%.

Other examples of models include but are not limited to Decision Tree, Linear Disciminant Analysis, Neural Network, Support Vector Machine, and k-Nearest Neighbor Classifier. A. person of ordinary skill in the art could use these different models to evaluate expression level data and comparative data involving expression levels of one or more miRs (or their precursors or their targets):

Models may take into account one or more diff pair values or they may also take into account differential expression of one or more miRNAs not specifically as part of a diff pair. A diagnostic score may be based on 1, 2, 3, 4, 5, 6, 7, 8 or more diff pair values (or any range derivable therein), but in some embodiments, it takes into account additionally or alternatively, 1, 2, 3, 4, 5, 6, 7; 8, 9, 10 or more miRNA expression levels (or any range derivable therein), wherein the miRNA expression level detectably differs between low risk and high risk lesions.

It will be understood by those of skill in the art that instead of a diff pair value, methods may involve a coefficient value that can be used in conjunction with the level of expression of a particular miRNA based on classifier analysis. Whereas the expression value associated with a diff pair is 1 times the expression value of the first miRNA of the pair summed with −1 times the expression value of the second miRNA of the diff pair, a more general classifier may be built with features composed of combinations of 2 or more miRNA expression values with coefficient values other than just 1 or −1.

Additionally, embodiments, may be based on a constrained logistic regression model. For illustrative purposes, consider a model built with three biomarker predictors A, B, and C. The classifier is specified by the weights w₀, w₁, w₂, and w₃: given a sample with expression value x₁ for marker A, x₂ for marker B, and x₃ for marker C, the model score may be computed as

$P_{malignant} = {\frac{1}{1 + {\exp \left( {- z} \right)}} = \frac{1}{1 + {\exp \left( {{- w_{0}} - {w_{1}x_{1}} - {w_{2}x_{2}} - {w_{3}x_{3}}} \right)}}}$ where $\begin{matrix} {z = {w_{0} + {w_{1}x_{1}} + {w_{2}x_{2}} + {w_{3}x_{3}}}} \\ {= {w_{0} + {w_{1}\left( {x_{1} - x_{2}} \right)} + {\left( {w_{1} + w_{2}} \right)\left( {x_{2} - x_{3}} \right)} + {\left( {w_{1} + w_{2} + w_{3}} \right)x_{3}}}} \end{matrix}$

Since a model may be constrained to satisfy w1+w2+w3=0, the last term m the above equation must vanish. But what's left expresses our model score in terms of the diff pairs Diff(A,B) (with expression value x1−x2) and Diff(B,C) (with expression value x2−x3). This argument can be extended in a straight-forward manner to apply to constrained logistic regression models with any number of predictors.

Alternatively, the converse may be done. A logistic regression model built using two DiffPairs, Diff(A,B) and Diff(C,D), with weights W₁ and W₂ can be equivalently described directly in terms of the underlying mils A, B, C, and D with weights w₁=W₁, w₂=−W₁, w₃=W₂, and w₄=−W₂ (in case of miR overlap, we just add together the relevant coefficients: e.g., if B=C, we would have w₁=W₁, w₂=−W₁+W₂, w₃=−W₂, with x₃ now describing the expression value of D). Because the weight of each diff pair appears twice in the resulting individual miRs, once with a positive sign and once with a negative sign, the sum of the resulting individual miR coefficients (the lower-case w₁'s) must be zero, satisfying our constraint condition.

IV. KITS

Any of the compositions described herein may be comprised in a kit. In a non-limiting example, reagents for isolating miRNA, labeling miRNA, and/or evaluating a miRNA population using an array, nucleic acid amplification, and/or hybridization can be included in a kit, as well as reagents for preparation of samples from thyroid samples. The kit may further include reagents for creating or synthesizing miRNA probes. Such kits may thus comprise, in suitable container means, an enzyme for labeling the miRNA by incorporating labeled nucleotides or unlabeled nucleotides that are subsequently labeled. In certain aspects, the kit can include amplification reagents. In other aspects, the kit may include various supports, such as glass, nylon, polymeric beads, and the like, and/or reagents for coupling any probes and/or target nucleic acids. Kits may also include one or more buffers, such as a reaction buffer, labeling buffer, washing buffer, or hybridization buffer, compounds for preparing the miRNA probes, and components for isolating miRNAs. Other kits may include components for making a nucleic acid array comprising miRNAs, and this, may include, for example, a solid support.

Kits for implementing methods described herein are specifically contemplated. In. some embodiments, there are kits for preparing miRNAs for multi-labeling and kits for preparing miRNA probes and/or miRNA arrays. In such embodiments, kits comprise, in suitable container means, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or more of the following: 1) poly(A) polymerase; 2) unmodified nucleotides (G, A, T, C, and/or U); 3) a modified nucleotide (labeled or unlabeled); 4) poly(A) polymerase buffer, 5) at least one microfilter; 6) label that can be attached to a nucleotide; 7) at least one miRNA probe; 8) reaction buffer; 9) a miRNA array or components for making such an array; 10) acetic acid; 11) alcohol; 12) solutions for preparing, isolating, enriching, and purifying miRNAs or miRNA probes or arrays. Other reagents include those generally used for manipulating RNA, such as formamide, loading dye, ribonuclease inhibitors, and DNase.

In specific embodiments, kits include an array containing miRNA. probes, as described in the application. An array may have probes corresponding to all known miRNAs of an organism or a particular tissue or organ in particular conditions, or to a subset of such probes. The subset of probes on arrays may be or include those identified. as relevant to a particular diagnostic, therapeutic, or prognostic application. For example, the array may contain one or more probes that are indicative or suggestive of 1) a disease or condition (thyroid cancer), 2) susceptibility or resistance to a particular drug or treatment; 3) susceptibility to toxicity from a drug or substance; 4) the stage of development or severity of a disease or condition (prognosis); and 5) genetic predisposition to a disease or condition.

For any kit embodiment, including an array, there can be nucleic acid molecules that contain or can be used to amplify a sequence that is a variant of, identical to, or complementary to all or part of any of the sequences disclosed herein. In certain embodiments, a kit or array can contain one or more probes for the miRNAs identified by sequences disclosed herein. Any nucleic acid discussed above may be implemented as part of a kit.

Components of kits may be packaged either in aqueous media or in lyophilized form: The container means of the kits will-generally include at least one vial, test tube, flask, bottle, syringe, or other container means, into which a component may be placed, and preferably, suitably aliquoted. Where there is more than one component in the kit (e.g., labeling reagent and label may be packaged together), the kit also will generally contain a second, third, or other additional container into which the additional components may be separately placed. However, various combinations of components may be comprised in a vial. The kits also may include a means for containing the nucleic acids, and any other reagent containers in close confinement for commercial sale. Such containers may include injection or blow molded plastic containers into which the desired vials are retained.

When the components of a kit are provided in one and/or more liquid solutions, the liquid solution may be an aqueous solution, with a sterile aqueous solution being particularly preferred.

However, the components of a kit may be provided as dried powder(s). When reagents and/or components are provided as a dry powder, the powder can be reconstituted by the addition of a suitable solvent. It is envisioned that the solvent may also be provided in another container means. In some embodiments, labeling dyes are provided as a dried power. It is contemplated that 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 120, 130, 140, 150, 160, 170, 180, 190, 200, 300, 400, 500, 600, 700, 800, 900, 1000 μg, or at least or at most those amounts, of dried dye are provided in kits. The dye may then be resuspended in any suitable solvent, such as DMSO.

The container means will generally include at least one vial, test tube, flask, bottle, syringe and/or other container means, into which the nucleic acid formulations are placed, for example, suitably allocated. Kits may also comprise a second container means for containing a sterile, pharmaceutically acceptable buffer and/or other diluent.

Kits may include a means for containing the vials in close confinement for commercial sale, such as, e.g., injection and/or blow-molded plastic containers into which the desired vials are retained.

Such kits may also include components that facilitate isolation of the labeled miRNA. It may also include components that preserve or maintain the miRNA or that protect against its degradation. Such components may be RNAse-free or protect against RNAses. Such kits generally will comprise, in suitable means, distinct containers for each individual reagent or solution.

A kit may also include instructions for employing the kit components as well the use of any other reagent not included in the kit. Instructions may include variations that can be implemented.

Kits may also include one or more of the following: control RNA; nuclease-free water; RNase-free containers, such as 1.5 ml tubes; RNase-free elution tubes; PEG or dextran; ethanol; acetic acid; sodium acetate; ammonium acetate; guanidinium; detergent; nucleic acid size marker; RNase-free tube tips; and RNase or DNase inhibitors.

It is contemplated that such reagents are embodiments of kits. Such kits, however, are not limited to the particular items identified above and may include any reagent used for the manipulation or characterization of miRNA.

V. EXAMPLES

The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples that follow represent techniques discovered by the inventors to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art will, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments that are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1

The goal was to identify classifiers than can accurately distinguish benign thyroid conditions from malignant thyroid tumors, including mutation- and translocation-negative tumors, in preoperative thyroid FNAs. Papillary thyroid carcinomas are characterized, in particular, by the up-regulation of three miRNAs, miR-146b, miR-221, and miR-222, which is even more pronounced in BRAF V600E-positive tumors.

The classifier consists of a mathematical algorithm to predict probability of malignancy from the qRT-PCR measurements of the expression levels of the following microRNA species in FNA samples: miR-7, miR-21, miR31, miR-34a, miR-138-1, miR-139-5p, miR-141, miR-145, miR-146b-3p, miR-146b-5p, miR-155, miR-183, miR-197, miR-222, miR-224, miR-375, and miR-425. These microRNAs were identified through statistical differential expression analysis of fresh frozen and FFPE samples comparing various benign and malignant sample types, FIG. 1 illustrates the differentially expressed miRNAs identified from FFPE Samples. FIG. 1A reflects 18 differentially expressed miRs identified by LIMMA ANOVA analysis of Affymetrix miRNA array data (all significant at p<0.05 after Benjamini-Hochberg FDR adjustment). This analysis, in conjunction with pair-wise comparisons between different sample subgroups, led to the identification of a set of miRNAs for qRT-PCR Analysis. Good correlation was observed for benign-vs-malignant fold changes (shown as log-ratios for array and delta-Ct for PCR) between the array data and the PCR data for selected miRNA chosen for assay in FNA set 1 (B) and FNA set 2 (C), B=benign conditions other than FA.

This was followed by a second round of feature selection conducted. by L1-constrained logistic regression modeling. Prior indication of differential expression of microRNA species in the literature was considered as an additional factor for those miRs which were found to be strongly predictive of malignancy status in regression modeling. FIG. 5 illustrates the approach for modeling the distinction between benign and malignant FNA samples used.

The first analysis revealed BRAF V600E mutation to be a confounding factor for the development of classifiers. FIG. 2 illustrates miRNA expression in FNA specimens correlated with mutational status. Principal Components Analysis (PCA) applied to qRT-PCR data (raw Ct values) derived from FIG. 2A FNA set 1 and FIG. 2B FNA set 2. Both sets show clear separation of BRAF-mutation positive samples from benign, less separation between mutation-negative malignant samples and benign samples. B_neg=benign, mutation-negative; M_BRAF=malignant, V600E mutation-positive; M_RAS=malignant, RAS mutation-positive; M_neg=malignant, mutation-negative. A preliminary logistic regression classifier for FNA samples is shown in FIG. 3, miR-146b and miR-222 show strongly differential expression between BRAF WT and mutant populations, but are much less useful for distinguishing mutation negative malignant from benign, specimens. FIG. 4 illustrates that the strongest miRNA signals in FNAs correlate with BRAF status. Logistic model fit to merged FNA set (using 11 miRNA species assayed on both FNA sets). Model was fit using λ₁ penalized regression to DiffPaired. data. The performance of this model was assessed using 5-fold cross-validation, with resulting malignancy predictions shown in FIG. 4A and resulting ROC curve shown in FIG. 4B. Four DiffPairs received non-zero weights in final model, with the top two DiffPairs (values shown in FIG. 4C) having >5-fold larger weights than the bottom two.

As BRAF V600E is highly specific, of malignancy, the inventors focused subsequent analyses on FNA specimens that were BRAF wild-type. This allowed the inventors to show that classifiers based on miRs-375 and miR-7, among others, show promise for identification of BRAF wild-type malignancies in FNA biopsies.

Materials and Methods

To identify candidate miRNAs, two independent sets of thyroid samples were procured that corresponded to a variety of benign and malignant conditions. The two sample sets consisted. of 46 fresh frozen biopsies (data not shown) and 55 formalin-fixed paraffin-embedded (FEPE) samples, respectively. Total RNA was isolated from FFPE samples using the RecoverAll kit (Ambion), miRNA expression profiles were established on Affymetrix GeneChip miRNA 2.0 Arrays (Affymetrix) that target 1,105 human miRNAs from the Sanger database V15 (FFPE specimens). The samples were divided into benign and malignant groups for analysis, according to histology.

FNAs were obtained from an on-going multi-center study. Total nucleic acids were isolated from the FNAs using a proprietary method developed by Asuragen. qRT-PCR reactions were performed using specific TaqMan miRNAs assays (Applied Biosystems), as selected from the array data analysis.

Affymetrix GeneChip miRNA Service Methods Summary

Sample and Array Processing.

Samples for miRNA profiling studies were processed by Asuragen Services (Austin, TX), according to the company's standard operating procedures. Following incoming sample quality control (QC) assessment, the 3′ ends of RNA molecules in total RNA samples were labeled with biotin according to the company's standard protocol. Labeled RNA (100 ng total RNA per sample) was purified and hybridized to Affymetrix GeneChip® miRNA Arrays (Affymetrix, Santa Clara, Calif.). Hybridization, washing, staining, imaging, and signal extraction were performed according to Affymetrix-recommended procedures. Arrays were scanned on an. Affymetrix GeneChip® Scanner 3000 7G.

Normalization and Summarization.

Probe level summaries were extracted using median polish and Variance Stabilization Normalization (VSN) was applied to the array data. This is a global normalization approach that models the quadratic relationship between the variance of microarray data and the signal intensity, and transforms the data such that the variance is roughly constant. The post-normalized data scale is reported as generalized log 2 data. As the distribution of microarray data tends to approximately follow a normal distribution pattern after log transformation, this transformation helps to render normalized data amendable to classical statistical treatments, including t-tests and ANOVA.

Statistical Hypothesis Testing.

The signal processing implemented for the Affymetrix miRNA array is a multi-step process involving probe specific signal detection calls, background correction, and array scaling. For each probe, the contribution of signal due to background Was estimated and removed by the feature extraction software as part of the data file output. Similarly, detection calls were based on the feature extraction software. Arrays within a specific analysis experiment were normalized together according to the VSN scaling method.

The signal processing implemented for the Affymetrix miRNA array is a multi-step process involving probe specific signal detection calls, background correction, and global normalization. For each probe, the contribution of signal due to background was estimated and removed by the feature extraction software as part of the data file output. Similarly, detection calls were based on the feature extraction software. Arrays within a specific analysis experiment were normalized together according to the VSN method described by Bolstad B et al [1].

The signal processing implemented for the Affymetrix miRNA array is a multi-step process involving probe specific signal detection calls, background estimate and correction, constant variance stabilization and log 2 transformation. For each probe, an estimated background value is subtracted that is derived from the median signal of a set of G-C-matched anti-genomic controls. Detection calls were based on a Wilcoxon rank-sum test of the miRNA probe signal compared to the distribution of signals from GC-content matched anti-genomic probes.

The signal processing implemented for the Affymetrix miRNA array is a multi-step process involving probe specific signal detection calls, background correction, and array scaling. For each probe, the contribution of signal due to background was estimated and removed by the feature extraction software as part of the data file output. Similarly, detection calls were based on the feature extraction software. Arrays within a specific analysis experiment were normalized together according to the VSN scaling method to the 1^(th) percentile.

For statistical hypothesis testing, both equal variance two-sample t-Tests and one-way ANOVA were applied using empirical Bayes methods. (as implemented by the Limma R package) to shrink individual miRNA variances towards a common value. This approach of borrowing information from the entire set of miRNAs increases the stability and power of the statistical test. All p-values are adjusted for false discovery rate using the method described by Benjamini & Hochberg (Benjamini & Hochberg (1995)) to account for testing all human mature miRNAs for differential expression.

Sample Information.

A total of 55 formalin-fixed paraffin-embedded (FFPE) samples from 31 benign and 24 malignant neoplasms were purchased from Asterand (Asterand Plc., Detroit, Mich., USA). The benign samples corresponded to 11 hyperplastic nodules (HN), 10 follicular adenomas (FA), 2 oncocytic follicular adenoma (OFA), 4 multi nodular goiter (MNG), and 4 Hashimoto's thyroiditis (HASH). The malignant samples corresponded to 8 papillary carcinomas (PTC), 5 follicular variant of papillary carcinomas (FVPTC), 2 follicular carcinomas (FTC), 2 oncocytic variant of follicular carcinoma (OFTC), 3 anaplastic carcinoma (ATC), and 4 medullary carcinomas (MED). Information regarding these samples is provided in Table 2. Total RNA was isolated from each sample, using the RecoverAll RNA Isolation Kit (Ambion; Austin, Tex., USA). Total RNA was quantified using a NanoDrop® ND-1000 spectrophotometer (NanoDrop Technologies Inc, Wilmington, Del., USA).

TABLE 2 Patient information and histopathological data for the thyroid FFPE samples. Age at Excision AJCC/ AJCC/UICC Sample ID Histopathology Excision Sex Ethnicity Year UICC Stage Stage Group AF 91 ATC 62 Male Caucasian 2000 T4aNXMX IVA AF 101 ATC 76 Female Caucasian 2004 T4aN1aMX IVA AF 102 ATC 49 Male Caucasian 2005 T4aN1bMX IVA AF62 ATC N/A N/A N/A N/A N/A N/A AF60 FA 38 Male Caucasian 2004 AF63 FA 65 Female Caucasian 1995 AF71 FA 47 Female Caucasian 1995 T2NXMX II AF76 FA 69 Male Caucasian 2004 AF77 FA 71 Female Caucasian 2004 T2NXM0 II AF81 FA 30 Female Caucasian 2001 AF82 FA 66 Female Caucasian 2001 AF83 FA 35 Female Caucasian 2001 AF88 FA 68 Female Caucasian 2006 T1NXMX I AF113 FA 63 Female Asian/ 2001 Pacific Islander AF64 FTC 47 Female Caucasian 1995 T2NXMX II AF 111 FTC 56 Female Caucasian 2008 T2N0MX II AF47 FVPTC 80 Female Caucasian 2009 T2N0M0 II AF61 FVPTC 67 Male Caucasian 1993 T3NXMX III AF67 FVPTC 42 Female Caucasian 1996 T3NXMX III AF72 FVPTC 25 Female Caucasian 1993 T1bN1MX I AF 107 FVPTC 63 Male Caucasian 2009 T2N0MX II AF50 HASH 41 Female Caucasian 2010 T1aNXMO I AF54 HASH 62 Female Caucasian 1995 T3NXMX III AF74 HASH 36 Female Caucasian 1995 AF75 HASH 45 Female Asian/ 1995 T1aN0MX I Pacific Islander AF70 MED 62 Female Caucasian 1996 T3NXMX III AF 99 MED 37 Male Native American/ 2003 T3N1bMX IVA Alaskan AF 104 MED 60 Female Caucasian 2007 T2N1bMX IVA AF 90 MNG 48 Male Caucasian 2000 AF 95 MNG 47 Female Caucasian 2001 AF 96 MNG 67 Female Caucasian 2002 AF 98 MNG 60 Female Caucasian 2003 AF48 NH 22 Female Caucasian 2009 T3N1M0 I AF49 NH 64 Female Caucasian 2009 AF53 NH 70 Male Caucasian 2009 AF55 NH 50 Female Caucasian 2008 T1NXM0 I AF56 NH 61 Female Caucasian 2008 TXNXM0 AF57 NH 80 Female Caucasian 2008 T2N1M1 IV AF58 NH 46 Female Caucasian AF59 NH 66 Male Caucasian 2004 AF66 NH 44 Female Caucasian 1996 T1bN1MX III AF78 NH 82 Male Caucasian 2004 AF87 NH 57 Female Caucasian 2006 T1NXMX I AF 108 OFA 56 Female Caucasian 1997 AF110 OFA 38 Male Caucasian 2001 AF69 OFTC 46 Female Caucasian 1996 T3NXMX III AF 92 OFTC 86 Female 2000 T2N1MX III AF52 PTC 38 Female Caucasian 2009 T2NXMX I AF85 PTC 45 Female Caucasian 2006 T2N0M0 II AF86 PTC 77 Female Caucasian 2006 T1NXMX I AF89 PTC 46 Female Caucasian 2006 T1NXMO I AF 100 PTC 55 Female Caucasian 2003 T3N1bMX IVA AF 103 PTC N/A N/A N/A N/A N/A N/A AF 105 PTC 61 Male Caucasian 2008 T3N1bM0 IVA AF 109 PTC 79 Male Caucasian 1999 T4aN1MX IVA Anaplastic cancer (ATC); Follicular Adenoma (FA); oncocytic FA (OFA); Follicular carcinoma (FTC); oncocytic FTC (OFTC); Papillary carcinoma (PTC); Follicular variant of PTC (FVPTC); medullary cancer (MED); Hashimoto's thyroiditis (HASH); multinodular goiter (MNG); hyperplastic nodules (HN)

Two sets of fine needle aspiration (FNA) biopsies were used, each of these sets containing both benign and malignant FNA samples, as determined by cytology. Malignancy was confirmed by histology after resection of the lesion (Tables 3A and 3B). Molecular testing was performed using Asuragen miRInform™ Thyroid mutation panel assay.

TABLE 3A Patient information and pathological reports on the first set (Set1) of FNA samples used as a training set for the development of the miRNA classifier Histopathology Sample report after Molecular ID Age Gender Cytology Location surgery testing results FNA1 55 M Benign right FA Neg FNA2 24 M Benign right middle Neg FNA3 53 F Benign right lower Neg FNA4 27 F Benign right Neg FNA5 28 F Benign left Neg FNA6 58 F Benign Left Neg FNA7 48 F Benign left upper Neg FNA8 81 F Benign left lower Neg FNA9 32 F Positive Papillary right middle PTC BRAF V600E Carcinoma FNA10 44 F Positive Papillary left lower PFVPTC NRAS Q61R Carcinoma FNA11 66 F Positive Papillary right FVPTC Neg Carcinoma FNA12 46 F Positive Papillary left middle FVPTC BRAF V600E Carcinoma FNA13 22 F Positive Papillary left middle FVPTC BRAF V600E Carcinoma FNA14 43 M Positive Papillary left lower FVPTC BRAF V600E Carcinoma

TABLE 3B pathological reports and mutation status on the FNAs used as the second set (Set 2) of FNA samples used for the development of a miRNA classifier Sample SURGERY/ ID CYTOLOGY REPORT HISTOLOGY Mutational status Benign lesions Mutation negative FNA15 HASH N/A Neg FNA16 Benign N/A Neg FNA17 Benign N/A Neg FNA18 Benign N/A Neg FNA19 Benign N/A Neg Benign lesions Mutation-positive FNA20 Benign N/A KRAS7 G12V FNA21 Benign N/A PPFP FNA22 AUS/FLUS N/A HRAS G12V FNA23 Benign N/A NRAS Q61K FNA24 FLUS/AUS N/A PAX8/PPARg PTC mutation negative FNA25 FLUS/AUS FVPTC Neg FNA26 FLUS/AUS FVPTC neg FNA27 FLUS/AUS FVPTC neg FNA28 FLUS/AUS PTC Neg FNA29 FLUS/AUS PTC Neg PTC mutation-positive FNA30 Malignant FVPTC NRAS Q61R FNA31 Malignant FVPTC NRAS Q61R FNA32 Suspicious for malignancy FVPTC HRAS Q61R FNA33 Suspicious for neoplasm FVPTC NRAS Q61R FNA34 Suspicious for malignancy FVPTC HRAS Q61R FNA35 PTC PTC BRAF V600E

FNA specimens, corresponding to an entire extra-pass, were collected according to the institutional IRB-approved protocol as a part of standard clinical care, and all samples were de-identified. Upon collection, FNAs were placed in 1 mL of Asuragen's RNARetain™ nucleic acid stabilization solution and shipped to Asuragen at room temperature for molecular testing. Total RNA was extracted using a modified mirVana PARIS™ procedure and proprietary Asuragen protocols optimized for recovery of nucleic acids from RNARetain. Concentration and purity of RNA were measured using the NanoDrop ND-1000 Spectrophotometer (NanoDrop Technologies Inc., Wilmington, Del., USA).

Sample Description

No. of FFPE Category Samples Histopathology 55 Benign 31 HN (11); FA (10); OFA (2); MNG (4); HASH (4) Malignant 24 PTC (8); PVPTC (5); FTC (2); OFTC (2); MED (3); ATC (4) No. of FNAs Category Samples Cytology Surgery/Histology Mutational status* Set 1 = 14 Benign (8)  8 Non malignant cells FA (1) Neg Malignant (6)  6 Malignant FVPTC (4), PTC (2) BRAF V600E (4) NRAS Q61R (1) Set 2 = 20 Benign Mut neg (5)  4 Non malignant cells N/A Neg  1 Hashimoto N/A Neg Begnign Mut pos (5)  3 Non malignant cells N/A KRAS G12V (1) NRAS Q6IK (1) PAX8/PPARg (1)  2 AUS/FLUS N/A HRAS G12V (1) PAX8PPARg (1) Malignant Mut neg (5)  5 AUS/FLUS PTC (2) FVPTC (3) Neg Malignant Mut pos (5)  2 Malignant PTC (2) NRAS Q61R (2)  2 Susp for malignancy FVPTC (2) HRAS Q61R (2)  1 Suspfor neoplasm FVPTC (1) NRAS Q51R (1) *The mutational status of these samples was established using Asuragen's Luminex-based Research Assay. Benign lesions: hyperplastic nodule (HN); Follicular adenoma (FA); oncocytic follicular adenoma (OFA); multinodular goiter (MNG); Hashimoto's thyroiditis (HASH); Malignant lesions: papillary carcinoma (PTC); follicular variant of papillary carcinoma (FVPTC); follicular carcinoma (FTC); oncocytic follicular carcinoma (OFTC); medullary cancer (MED); anaplastic carcinoma (ATC)

Example 2 miRNAs can Distinguish Benign and Malignant Thyroid Neoplasms

A total of 55 FFPE samples from from 31 benign and 24 malignant neoplasms were profiled using the Affymetrix GeneChip® miRNA Arrays V2 in Asuragen Services and then analyzed by Asuragen's bioinformatics group (Asuragen). The Affymetrix miRNA arrays contain probes for more than 1,000 human miRNAs from Sanger miRBase VII.0 (available on the world wide web at asuragen.com/Services/services). A total of 200 ng of total RNA corresponding to each of the 55 samples was labeled as described in. the materials and methods. The samples were separated in 2 different groups for analysis, corresponding to Benign (hyperplastic nodules (HN; n=11), follicular adenoma (FA; n=10), oncocytic follicular adenoma (OFA; n=2), multi nodular goiter (MNG; n=4), and Hashimoto's thyroiditis (HASH; n=4) and Malignant (papillary carcinomas (PTC; n=8), follicular variant of papillary carcinomas (FVPTC; n=5), follicular carcinomas (FTC; n=2), oncocytic variant of follicular carcinoma (OFTC; n=2), anaplastic carcinoma (ATC; n=4), and medullary carcinomas (MED; n=4). The average levels of expression of each miRNA within each group of samples are shown in Tables 4A-D.

TABLE 4A normalized array data for the 55 benign and malignant FFPE samples. Hyperplastic nodule (HN); follicular adenoma (FA); oncocytic FA (OFA), multinodular goiter (MNG). Average Expression miRNA HN (Mean) FA (Mean) OFA (Mean) MNG (Mean) has-let-7a_st 15.33134637 14.24099186 11.7936842 13.4739347 has-let-7a-star_st 2.110895451 1.791791809 1.248074076 1.173824172 has-let-7a-2-star_st 4.860529413 4.586453364 5.269724619 4.937201273 has-let-7b_st 14.69413715 13.25913718 10.57489326 12.14642872 has-let-7b-star_st 6.792844262 7.117992036 7.662555232 7.530672855 has-let-7c_st 15.23062851 13.88133156 11.35091982 12.99181533 has-let-7c-star_st 4.171332397 3.806653704 4.425062721 4.218655511 hsa-let-7d_st 14.76346582 13.81262879 11.64571066 12.62751338 hsa-let-7d-star_st 8.53187748 8.098607654 7.766016534 8.079830029 has-let-7e_st 13.09541233 12.28617016 10.45250531 11.10540492 has-let-7e-star_st 4.215115082 4.609380325 4.55332673 4.058074559 hsa-let-7f_st 14.59342893 13.91129749 11.51510071 12.76865153 hsa-let-7f-1-star_st 3.530423518 4.395882486 5.171252468 4.777049014 hsa-let-7f-2-star_st 1.650535016 1.454440181 2.457326428 1.573903791 hsa-miR-15a_st 10.06262181 10.33242942 6.089214326 7.032466977 hsa-miR-15a-star_st 3.374005266 3.850024561 4.930377243 4.45707072 hsa-miR-16_st 13.65491454 13.05403302 9.753821444 11.81436974 hsa-miR-16-1-star_st 2.884220775 3.157135553 3.116583089 2.04270118 hsa-miR-17_st 10.3925651 9.511397276 6.805043509 7.53169487 hsa-miR-17-star_st 4.982267167 6.18280036 4.656587948 3.927135405 hsa-miR-18a_st 4.575647081 4.114891284 3.099195998 2.671173077 hsa-miR-18a-star_st 4.768566013 5.071700097 5.116458511 4.069444557 hsa-miR-19a-star_st 0.951157914 0.390178671 0.159125319 0.740013802 hsa-miR-19a_st 4.165326791 4.720638613 1.708514281 2.456917344 hsa-miR-19b-1-star_st 2.486422955 2.619038729 2.290072306 2.393443376 hsa-miR-19b_st 9.547185652 9.231137075 5.898956336 7.370312978 hsa-miR-19b-2-star_st 0.814341412 1.154489192 0.393980058 1.303815242 hsa-miR-20a_st 9.756100841 9.082626556 6.966591876 6.063871985 hsa-miR-20a-star_st 5.973104762 5.932765668 7.793689194 6.583224777 hsa-miR-21_st 11.01084597 10.74976677 7.569426583 8.956136328 hsa-miR-21-star_st 5.608680329 5.617396845 5.793445199 6.336205876 hsa-miR-22-star_st 7.067117077 7.346201177 4.991743417 5.122410063 hsa-miR-22_st 12.41582277 11.57063023 10.08266085 10.1423768 hsa-miR-23a-star_st 10.49987149 10.52086187 11.25819113 11.31269572 hsa-miR-23a_st 14.87227126 13.69208321 11.11631748 12.79184378 hsa-miR-24-1-star_st 2.959612098 3.542333549 0.864472389 1.395382794 hsa-miR-24_st 13.72162874 12.71103737 10.21179484 11.31904231 hsa-miR-24-2-star_st 4.835122145 5.082053254 3.962836564 2.853893061 hsa-miR-25-star_st 12.29983445 12.10747545 12.6415432 13.06917051 hsa-miR-25_st 10.93305799 10.19648078 7.313209378 9.406423011 hsa-miR-26a_st 15.44341098 14.52683697 12.1348761 13.63241759 hsa-miR-26a-1-star_st 1.682603238 1.846078022 2.928478151 2.2429861 hsa-miR-26b_st 11.82468346 11.68895799 8.366104012 10.13776415 hsa-miR-26b-star_st 5.276948079 5.275218808 3.006360752 3.59024221 hsa-miR-27a-star_st 5.23209868 4.753705437 4.671827788 4.703555096 hsa-miR-27a_st 12.12234929 11.53552561 6.637891757 9.664558579 hsa-miR-28-5p_st 8.123312706 8.360312589 6.18153165 6.72334116 hsa-miR-28-3p_st 6.830527448 6.407299605 3.670113324 4.978559366 hsa-miR-29a-star_st 1.748267835 2.022443862 0.00546112 1.100842105 hsa-miR-29a_st 13.680311679 12.93575986 10.37410826 11.25896547 hsa-miR-30a_st 13.05130132 12.0149128 9.067793345 10.88559904 hsa-miR-30a-star_st 11.09923524 10.23710648 6.475475296 8.452538111 hsa-miR-31_st 9.619647188 8.101965364 5.571869825 6.623018309 hsa-miR-31-star_st 2.677595202 1.918786537 0.864348119 0.150686423 hsa-miR-32_st 1.166563361 0.836690028 −0.373473207 0.156618925 hsa-miR-32-star_st 3.349009922 2.998726344 1.910695921 2.35793901 hsa-miR-33a_st 0.756242573 0.586972588 −0.061997733 0.130096997 hsa-miR-33a-star_st 2.171593172 2.309149985 2.365761712 0.235256468 hsa-miR-92a-1-star_st 7.976558893 8.085757731 8.829550884 8.369285127 hsa-miR-92a_st 11.45554953 10.64283391 8.777991244 9.730037613 hsa-miR-92a-2-star_st 9.09449318 8.980932369 9.60951049 9.855146145 hsa-miR-93_st 9.897781626 9.310W4419 7.657767503 7.279514837 hsa-miR-93-star_st 4.539168591 4.339508228 4.592281692 3.467935794 hsa-miR-95_st 8.086443894 7.894299767 5.350165578 5.503750948 hsa-miR-96_st 5.246328885 5.913103579 2.174771127 3.61434929 hsa-miR-96-star_st 3.683589729 3.078257283 2.31660147 2.846710637 hsa-miR-98_st 9.554020646 9.263015883 7.364675578 7.611944543 hsa-miR-99a_st 12.92654872 11.84990568 8.268397439 11.00189645 hsa-miR-99a-star_st 4.828002098 4.245132921 2.021521485 2.729973125 hsa-miR-100_st 13.07416587 11.57836561 8.999592205 11.29685279 hsa-miR-100-star_st 2.776758472 1.815709837 1.447129752 2.093577305 hsa-miR-101-star_st 2.156574473 2.064826172 1.749691952 1.480993166 hsa-miR-101_st 4.862240083 5.67878915 2.290794179 3.151929802 hsa-miR-29b-1-star_st 5.799259779 6.040138604 4.711839376 3.943970648 hsa-miR-29b_st 11.26582032 11.28784293 8.132559788 8.614078976 hsa-miR-29b-2-star_st 7.942549396 8.190596694 5.872576721 6.549234697 hsa-miR-103-2-star_st 3.806061097 5.06901149 5.718608473 4.721570025 hsa-miR-103_st 12.72342206 12.25753739 10.23814663 10.82241984 hsa-miR-105_st 1.780457626 2.429907613 0.757591376 1.432887998 hsa-miR-105-star_st 2.893660905 3.016586842 2.251257711 2.755948349 hsa-miR-106a_st 10.63596087 9.611018622 7.50045103 7.637153639 hsa-miR-106a-star_st 1.324502017 1.362145996 0.572682676 1.486150452 hsa-miR-107_st 12.40095928 12.07296552 10.12538705 10.71427874 hsa-miR-16-2-star_st 3.21179161 2.651708224 4.184852424 2.497404416 hsa-miR-192_st 6.947694459 7.161749822 4.862597963 4.341260452 hsa-miR-192-star_st 3.425682817 3.934343476 3.148794448 3.01583634 hsa-miR-196a_st 2.358492407 2.643032944 0.937628053 1.307525843 hsa-miR-197_st 7.888822541 7.825775748 7.779642934 7.19135433 hsa-miR-198_st 12.04045943 11.9966779 12.75041315 13.27009679 hsa-miR-199a-5p_st 10.64633486 8.622377942 4.90208252 7.077998366 hsa-miR-199a-3p_st 12.02658343 10.33078881 4.677455466 7.918235101 hsa-miR-208a_st 2.353943003 2.570362952 3.249730736 2.240290791 hsa-miR-129-5p_st 11.14222665 11.17707535 12.45432092 12.5561397 hsa-miR-129-star_st 4.074661718 4.057992762 3.085871775 3.59562257 hsa-miR-148a-star_st 4.281543145 4.520590327 4.271130416 3.623976363 hsa-miR-148a_st 9.953417333 10.16665643 7.129153945 8.872673591 hsa-miR-30c_st 13.78327519 13.25445044 11.45097637 12.68202159 hsa-miR-30c-2-star_st 7.552599179 7.475386616 8.067753581 7.42365416 hsa-miR-30d_st 12.79683497 11.72930698 9.664865878 10.59133543 hsa-miR-30d-star_st 2.51590425 2.159646456 0.311206626 0.964248287 hsa-miR-139-5p_st 8.001245997 7.12292897 3.3781163 5.905172009 hsa-miR-139-3p_st 7.849404245 7.344998178 8.324273659 8.027381198 hsa-miR-147_st 4.304495246 4.188206507 3.452829167 3.961008631 hsa-miR-7_st 8.623874667 9.966740157 4.356877889 7.670837028 hsa-miR-7-1-star_st 5.652010926 6.366677192 5.310172856 5.580097263 hsa-miR-7-2-star_st 6.720183564 7.452894481 5.222031053 6.186775963 hsa-miR-10a_st 8.596946346 7.735623047 5.010738844 5.685383228 hsa-miR-10a-star_st 4.162138961 4.068309051 4.210632206 3.430793953 hsa-miR-10h_st 9.374464963 8.112435575 4.892606616 6.837048224 hsa-miR-10b-star_st 3.652693175 4.033819926 4.540840238 2.614435167 hsa-miR-34a_st 8.857810399 9.379133916 7.323260879 6.853769689 hsa-miR-34a-star_st 5.680199931 5.391458652 3.324502218 4.12653636 hsa-miR-181a_st 12.40474448 12.27414864 8.939235919 11.33971306 hsa-miR-181a-2-star_st 7.475698088 8.418060867 5.114817398 6.56463499 hsa-miR-181b_st 11.05275668 11.00758045 8.229311624 9.934662767 hsa-miR-181c_st 7.894910188 8.46517983 5.921284705 7.125742808 hsa-miR-181c-star_st 5.59934365 6.466167443 6.307881357 6.45427408 hsa-miR-182_st 7.524211555 8.899339742 6.702345889 7.901414189 hsa-miR-182-star_st 2.032582862 2.131259034 2.420276869 1.914366526 hsa-miR-183_st 4.66769888 6.196534354 5.5375514 4.179341993 hsa-miR-183-star_st 6.541125284 6.61979709 7.97705585 7.539169489 hsa-miR-187-star_st 9.454544796 9.457251443 10.26412464 10.5096408 hsa-miR-187_st 3.307934048 4.333924292 4.44680084 2.875484864 hsa-miR-196a-star_st 3.847132501 4.168709422 4.243851953 4.586396171 hsa-miR-199b-5p_st 8.067967522 4.529025777 1.057041185 2.807380212 hsa-miR-199b-3p_st 11.79350667 10.21604343 5.366542865 7.724606411 hsa-miR-203_st 7.600749502 6.444237644 5.083414382 5.290557638 hsa-miR-204_st 7.411721036 8.37308567 3.313088111 6.794870821 hsa-miR-205_st 3.990158386 4.644758066 3.280489258 2.737388309 hsa-miR-205-star_st 4.930894679 4.889438806 4.733235709 4.600157867 hsa-miR-210_st 12.60042133 12.26927293 13.01961584 13.19596831 hsa-miR-211_st 4.298901289 5.27868152 6.154193409 5.562856306 hsa-miR-212_st 5.923072742 6.024019947 5.688406394 5.171673581 hsa-miR-181a-star_st 4.510047961 5.081552354 2.760137254 3.616997219 hsa-miR-214-star_st 5.245165628 4.519316903 3.855855626 3.385412432 hsa-miR-214_st 10.71268052 9.91797503 9.298130203 9.988812722 hsa-miR-215_st 3.785440755 3.90503273 2.553577367 2.89366364 hsa-miR-216a_st 2.340791519 1.787989914 2.069681995 1.72700379 hsa-miR-217_st 2.620723398 2.487393657 2.766473151 1.612522451 hsa-miR-218_st 5.153732024 3.280111348 2.277183206 1.176112602 hsa-miR-218-1-star_st 1.788750208 2.035094496 2.464154422 2.154916125 hsa-miR-218-2-star_st 3.587807606 2.993567475 4.378754516 2.636383899 hsa-miR-219-5p_st 0.384446566 0.404351952 0.367257754 0.972382583 hsa-miR-219-1-3p_st 3.980340937 4.428423134 5.231668266 4.726677154 hsa-miR-220a_st 1.640339861 2.122617922 3.214141295 2.315753506 hsa-miR-221-star_st 4.779248214 6.058598172 4.49356479 4.869230705 hsa-miR-221_st 12.11222807 12.00447403 11.5409352 11.18137776 hsa-miR-222-star_st 5.613675781 5.881210037 5.249988899 5.792583972 hsa-miR-222_st 11.94145868 11.72274824 10.5216812 10.95863898 hsa-miR-223-star_st 2.942046803 2.588409082 1.805067787 2.373048464 hsa-miR-223_st 9.121444916 7.868562683 5.322900131 8.121239409 hsa-miR-224_st 6.973063191 6.199613757 5.165652822 5.040369634 hsa-miR-224-star_st 5.272592145 5.165295017 5.834069212 4.419147963 hsa-miR-200b-star_st 6.468954011 6.923095776 5.623171152 5.555011611 hsa-miR-200b_st 11.54311053 11.15009086 4.73069754 8.346543019 hsa-let-7gt_st 13.90421406 13.0451982 10.62064191 11.92054208 hsa-let-7g-star_st 5.096948119 5.429245988 6.361792825 5.221381404 hsa-let-7i_st 14.39693639 13.50049584 11.15316808 11.62843114 hsa-let-7i-star_st 6.071489133 5.736371616 5.334407345 4.671001479 hsa-miR-1_st 5.244680127 3.281360125 1.476561852 1.68558141 hsa-miR-15b_st 11.2379346 10.38427128 6.998841053 9.0013019 hsa-miR-15b-star_st 3.025151958 2.86975036 3.343331646 2.516608009 hsa-miR-23b-star_st 5.136783023 5.338278615 4.77429646 4.952859227 hsa-miR-23b_st 14.88013629 13.87806044 11.49938663 13.22715344 hsa-miR-27b-star_st 5.860349798 5.964703663 4.120732943 5.199553354 hsa-miR-27b_st 12.52711974 11.7783819 7.444099046 9.901518021 hsa-miR-30b_st 12.11162383 12.0578777 9.35467279 10.84041239 hsa-miR-30b-star_st 8.589807707 8.683564575 9.55517825 9.459831779 hsa-miR-122_st 3.889363089 3.605838016 3.4816285 3.223910208 hsa-miR-122-star_st 1.278197653 1.643104396 1.587150542 2.170436413 hsa-miR-124-star_st 5.158307655 4.896442972 4.541563143 4.747548252 hsa-miR-124_st 8.125058861 7.698790095 8.018721262 8.380250026 hsa-miR-125b_st 15.37839298 14.14753725 11.38400455 13.87254178 hsa-miR-125b-1-star_st 11.77719511 11.4391194 12 34951892 12.58771937 hsa-miR-128_st 8.293931949 8.042393782 4.989677167 5.505274286 hsa-miR-130a-star_st 1.93755209 1.249764803 1.380648632 1.992896122 hsa-miR-130a_st 12.11274077 11.1906897 6.849160008 9.172153736 hsa-miR-132-star_st 3.028108399 2.374363338 1.668585891 1.551267999 hsa-miR-132_st 6.752557932 6.32167357 3.185423803 4.498883146 hsa-miR-133a_st 6.273986193 4.966813185 3.680650552 3.73965703 hsa-miR-135a_st 1.442072858 1.273841152 0.453637304 0.543004162 hsa-miR-135a-star_st 12.0538831 12.07507252 12.82743377 13.16900317 hsa-miR-137_st 0.846258755 1.204209133 1.178614116 1.799875927 hsa-miR-138_st 12.10998767 10.80333116 7.833281763 9.790973995 hsa-miR-138-2-star_st 3.725770208 3.979475207 3.060028878 3.201258328 hsa-miR-140-5p_st 4.445719261 4.424472562 2.138501593 3.070893966 hsa-miR-140-3p_st 11.03184716 10.30751232 8.999652593 9.601590353 hsa-miR-141-star_st 2.500630806 2.112760706 1.951732732 1.741624864 hsa-miR-141_st 9.443828533 9.149149511 5.261781871 5.725930731 hsa-miR-142-5p_st 2.960603358 1.133018333 1.910242498 1.397685481 hsa-miR-142-3p_st 0.436913361 0.340406984 0.836451958 0.578413651 hsa-miR-143-star_st 6.760170454 6.589048693 5.986821796 4.990739243 hsa-miR-143_st 12.92915097 12.04329338 8.808331832 10.46024021 hsa-miR-144-star_st 3.333436591 2.153373884 1.522915426 2.466154179 hsa-miR-144_st 1.061434367 1.681963838 0.79433018 1.194383941 hsa-miR-145_st 14.45965185 12.93912805 10.25706229 12.22629585 hsa-miR-145-star_st 5.459142581 5.63449693 2.591150728 3.632172912 hsa-miR-152_st 10.89837989 10.00742135 7.650372445 8.289858828 hsa-miR-153_st 1.668336474 0.953369544 1.48948361 1.893133761 hsa-miR-191_st 13.2433589 12.38587658 10.07738651 11.20928886 hsa-miR-191-star_st 5.623418766 5.752978332 7.07585322 6.888867875 hsa-miR-9_st 0.200051971 −0.001036009 −0.960945335 0.529803707 hsa-miR-9-star_st 1.963587273 1.83701144 1.734037582 1.383029455 hsa-miR-125a-5p_st 14.15012293 13.29195992 11.23217617 12.2855968 hsa-miR-125a-3p_st 11.71601853 11.63054033 12.64724621 12.54399405 hsa-miR-125b-2-star_st 8.573549739 9.333465713 9.580022539 10.07593647 hsa-miR-126-star_st 0.827289499 0.120824923 0.625448597 1.179293554 hsa-miR-126_st 13.8575686 13.23283164 10.81809315 11.65351557 hsa-miR-127-5p_st 4.998506022 6.006863057 6.602450467 6.112720967 hsa-miR-127-3p_st 6.299901407 5.907298634 5.904479109 5.479787341 hsa-miR-129-3p_st 2.892862083 3.120739671 2.933124943 2.303131348 hsa-miR-134_st 8.13753629 8.332181017 8.526153922 9.022439642 hsa-miR-136_st 0.448477925 0.423496568 −0.502198971 −0.338011523 hsa-miR-136-star_st 1.445986356 1.144262388 0.561324708 0.426275444 hsa-miR-138-1-star_st 8.172072602 7.691401796 6.048433919 7.06814545 hsa-miR-146a_st 8.573496171 7.898194922 3.851725058 5.818601668 hsa-miR-146a-star_st 1.053421606 1.03216522 −1.205914224 −0.203433661 hsa-miR-149_st 6.778957741 6.680207501 6.169160088 6.012200051 hsa-miR-149-star_st 16.63679017 15.53649106 15.33596685 16.2603804 hsa-miR-150_st 10.53473125 8.939972533 5.425106806 8.681398962 hsa-miR-150-star_st 13.01287248 12.78447723 13.49743366 13.89141157 hsa-miR-154_st 3.413323916 3.593041837 5.961831085 4.082194237 hsa-miR-154-star_st 3.156771561 3.151295405 3.59428388 2.822344894 hsa-miR-184_st 7.357860868 7.399794556 8.454248669 7.664804763 hsa-miR-185_st 9.977495773 9.288338231 8.5661096 8.409417083 hsa-miR-185-star_st 9.542286063 9.718285227 10.16615653 10.43786415 hsa-miR-186_st 4.957137934 4.793091495 3.894968795 2.474412628 hsa-miR-186-star_st 0.007183874 0.241908136 −0.098008813 0.009371155 hsa-miR-188-5p_st 6.339496652 6.94744166 7.035566183 7.640720401 hsa-miR-188-3p_st 2.957769448 3.631789929 4.133284855 4.165261444 hsa-miR-190_st −0.198930932 −0.159779808 −0.348645982 0.671634933 hsa-miR-193a-5p_st 12.78799963 12.0592054 12.91881181 12.88162155 hsa-miR-193a-3p_st 6.94786343 7.043553016 4.754336099 5.319876239 hsa-miR-194_st 7.017492693 7.375541124 5.095710626 4.494633514 hsa-miR-195_st 11.3535786 10.67223403 8.852363295 9.211213692 hsa-miR-195-star_st 4.186850367 5.069942912 5.370451755 4.387462401 hsa-miR-206_st 5.151152536 5.138838394 5.8758.03972 6.236512373 hsa-miR-320a_st 12.75601335 12.16351155 11.70853241 12.0843744 hsa-miR-200c-star_st 3.247825026 3.678655798 2.814796301 3.413083583 hsa-miR-200c_st 14.18967553 13.3364253 11.74345926 12.35648154 hsa-miR-155_st 8.730589163 7.866812975 7.141686282 6.923646844 hsa-miR-155-star_st 1.708696372 2.235610251 1.496025962 2.65311934 hsa-miR-194-star_st 8.363420627 8.134515441 9.19966909 9.020668454 hsa-miR-106b_st 9.443753896 8.78678085 7.278514787 6.290228412 hsa-miR-106b-star_st 7.65510332 7.581459882 5.688624992 6.877793128 hsa-miR-29c-star_st 7.730207062 7.793705132 4.692903533 4.43189257 hsa-miR-29c_st 11.47186231 11.14008205 7.940987224 9.252536909 hsa-miR-30c-1-star_st 10.03311133 10.52696772 11.28343633 11.29161533 hsa-miR-200a-star_st 5.386129455 5.988508997 6.157553693 5.631661946 hsa-miR-200a_st 10.20686655 10.01828691 3.626107869 6.440151698 hsa-miR-302a-star_st 2.29677852 2.417564798 1.909985007 2.017370516 hsa-miR-302a_st 1.943212782 2.038382097 0.847570677 1.696802531 hsa-miR-219-2.3p_st 6.384211662 6.84796628 7.403509876 6.95564895 hsa-miR-34b-star_st 3.96776278 4.450077534 1.879668192 3.01943276 hsa-miR-34b_st 6.488782204 6.791978638 7.622007236 5.130741926 hsa-miR-34c-5p_st 2.265367194 2.128246893 1.788225075 1.187697956 hsa-miR-34c-3p_st 5.648844974 6.034862127 6.722810019 6.965080001 hsa-miR-299-5p_st 5.333651397 5.183359463 5.943575776 6.016661536 hsa-miR-299-3p_st 6.826294477 6.947323606 7.273500585 7.988755583 hsa-miR-301a_st 2.762532729 4.459120962 2.121046356 1.098728607 hsa-miR-99b_st 11.29006217 11.00373647 9.244167232 9.673225273 hsa-miR-99b-star_st 8.123948973 7.999178731 7.593535396 7.586360852 hsa-miR-296-5p_st 3.5073761 3.950104577 4.402805231 3.556280624 hsa-miR-296-3p_st 11.84275434 11.69343684 12.22275471 12.4031653 hsa-miR-130b-star_st 4.3006712 4.787864482 5.621530214 3.505363021 hsa-miR-130b_st 8.069415741 7.966085461 6.908520896 6.830532025 hsa-miR-30c_st 9.916286045 9.375500175 6.920421411 7.481851102 hsa-miR-30c-star_st 9.97393791 9.189038026 6.439812195 7.208651868 hsa-miR-26a-2-star_st 0.485944001 0.742550412 -0.074385277 0.073748819 hsa-miR-361-5p_st 11.43155668 10.65424427 8.465368343 9.539945275 hsa-miR-361-3p_st 6.111144691 5.503239319 4.083824508 3.01892708 hsa-miR-362-5p_st 6.550553799 6.802218493 5.889063949 5.489351263 hsa-miR-362-3p_st 2.597326861 2.782580675 1.774631682 2.061467188 hsa-miR-363-star_st 9.805774014 10.26169981 10.62250696 10.34645701 hsa-miR-363_st 4.612048986 4.718494156 2.948400454 3.863134066 hsa-miR-365_st 3.251038937 2.938390188 2.119936982 1.189569168 hsa-miR-365-star_st 11.23199509 10.93822755 11.95642514 12.2120781 hsa-miR-302b-star_st 3.572040317 3.503688803 3.600937912 3.611414903 hsa-miR.302b_st 0.033323649 −0.393170571 −0.768068235 −0.343965405 hsa-miR-302c-star_st 7.760493288 7.954012322 8.415525113 8.391361632 hsa-miR-302c_st 1.690955922 0.933819172 −0.128455193 1.13539498 hsa-miR-302d-star_st 5.78022579 6.445257825 8.758538782 7.19114014 hsa-miR-302d_st 0.802038969 1.10649924 −0.791326765 0.032393695 hsa-miR-367-star_st 0.849235527 0.8293585 1.082638518 0.586027922 hsa-miR-367_st 1.481333238 1.677814743 1.632439354 0.64283786 hsa-miR-376c_st 4.404289644 3.407955004 2.884392604 2.707283391 hsa-miR-369-5p_st 3.316313348 2.504383425 3.419326232 2.614176447 hsa-miR-369-3p_st 0.875573431 0.904205693 0.342003115 1.69160154 hsa-miR-370_st 10.82969169 10.94663096 11.16653566 12.11914579 hsa-miR-371-5p_st 11.90934711 11.66559637 12.56358747 12.50287368 hsa-miR-371-3p_st 4.246194973 4.339071588 5.306187466 5.290201727 hsa-miR-372_st 1.93509982 3.52520786 3.019679412 3.201351804 hsa-miR-373-star_st 11.28905989 10.93617992 11.8747412 11.84282021 hsa-miR-373_st 4.471124146 5.482013599 4.208403642 3.175306358 hsa-miR-3274a_st 3.360307167 2.217833177 2.060223584 0.56219015 hsa-miR-374a-star_st 3.067930788 2.368403295 2.269822931 2.335118985 hsa-miR-375_st 4.525015112 4.183518117 4.48311008 5.255905778 hsa-miR-376a-star_st 1.018497211 0.471021763 −0.219261959 −0.180839728 hsa-miR-376a_st 3.224056473 3.299854677 3.015643213 3.811273006 hsa-miR-377-star_st 3.994718733 4.281197495 4.494361719 3.463604933 hsa-miR-377_st 2.325943038 2.249148846 1.625343402 1.177216491 hsa-miR-378-star_st 5.359169068 5.141947206 5.961592308 5.15803329 hsa-miR-378_st 8.431838262 8.315388395 8.236400731 8.412290166 hsa-miR-379_st 4.900723587 5.325461826 5.632275324 5.417886971 hsa-miR-379-star_st 2.61650132 2.13390947 2.858338364 1.86318168 hsa-miR-380-star_st 2.161005995 1.416477813 2.65340506 1.85269566 hsa-miR-380_st 0.47676769 0.934629691 2.292888159 1.328995858 hsa-miR-381_st 4.631497319 5.006094751 4.385840756 5.188608327 hsa-miR-382_st 6.707203209 6.750814145 6.756103695 6.746593018 hsa-miR-383_st 5.302844017 5.904030191 5.717461328 6.112890293 hsa-miR-340_st 2.683066352 3.607835834 2.903885794 0.794138602 hsa-miR-340-star_st 1.547599631 0.92586989 1.272914795 1.233087397 hsa-miR-330-5p_st 5.748135851 5.714421368 6.233296839 5.199805051 hsa-miR-330-3p_st 6.033132481 6.362149319 5.607454445 5.660787438 hsa-miR-328_st 7.701886329 7.732266124 8.251295114 8.124428329 hsa-miR-342-5p_st 4.83711592 5.712763178 4.603132218 3.998680061 hsa-miR-342-3p_st 10.27603077 9.599283817 7.855569042 8.676174783 hsa-miR-337-5p_st 2.557578229 2.698236984 3.148861902 2.640529145 hsa-miR-337-3p_st 3.68332555 3.754700167 4.266807042 4.019484846 hsa-miR-323-5p_st 10.83663792 10.88354069 11.8252232 11.86697029 hsa-miR-323-3p_st 3.333838722 3.396486231 2.850254661 3.347886918 hsa-miR-326_st 7.28135965 6.389662408 7.215417257 6.834417829 hsa-miR-151-5p_st 11.975172 11.06771751 8.475622115 9.708254107 hsa-miR-151-3p_st 8.927270185 8.232130651 5.063012396 5.735574621 hsa-miR-135b_st 1.600616842 1.808860403 1.46564086 −0.176298613 hsa-miR-135b-star_st 6.123792278 5.851599245 7.937067947 7.079881202 hsa-miR-148b-star_st 1.826120011 1.485945874 1.189040672 2.392090879 hsa-miR-148b_st 8.968059691 8.815196605 6.028009553 6.695467473 hsa-miR-331-5p_st 5.753981256 6.223558037 5.946357974 6.27132125 hsa-miR-331-3p_st 9.234004793 9.208916823 7.690096766 8.36528048 hsa-miR-324-5p_st 8.594595954 8.727897617 6.913057884 7.122355147 hsa-miR-324-3p_st 8.61194494 8.363209845 7.472679198 7.759121096 hsa-miR-338-5p_st 4.491954203 4.775885671 4.256418432 4.653229927 hsa-miR-338-3p_st 4.065521836 4.195282672 1.882692004 2.113323256 hsa-miR-339-5p_st 8.205156231 8.01607148 7.368147594 7.003609863 hsa-miR-339-3p_st 8.637127084 8.39558597 7.844275571 8.290510866 hsa-miR-335_st 7.641669829 8.129625783 6.032033565 4.932728299 hsa-miR-335-star_st 21.1661214 12.268402667 4.94377077 1.948471242 hsa-miR-133b_st 6.784666323 5.031078155 4.616784403 4.724209413 hsa-miR-325_st 2.853060648 3.471916375 3.80407475 3.874426834 hsa-miR-345_st 10.59851357 10.67912169 6.847310947 8.454577605 hsa-miR-346_st 9.555399031 8.870529479 9.021681576 9.960640594 hsa-miR-384_st 1.123490745 0.26558648 −0.390802462 1.069992765 hsa-miR-196b_st 2.264536781 2.484979009 2.707146152 1.967840156 hsa-miR-196b-star_st 5.948954768 6.276499498 6.569665412 6.28086413 hsa-miR-422a_st 8.983806534 8.882679037 9.87486563 9.208426926 hsa-miR-423-5p_st 13.3735062 12.89364059 13.50600485 13.84236238 hsa-miR-423-3p_st 10.00437156 9.466252103 8.634091295 8.638450528 hsa-miR-424_st 5.596922003 6.67092464 2.194584919 2.047772839 hsa-miR-424-star_st 8.399122813 8.384304438 7.662456086 8.058330009 hsa-miR-425_st 7.691072671 8.199186389 5.446019415 6.531060359 hsa-miR-425-star_st 7.838181658 7.947874031 8.31796297 8.198626856 hsa-miR-18b_st 3.714007434 3.553028844 2.001169269 2.74027829 hsa-miR-18b-star_st 3.975634589 3.837724999 5.73034459 4.214748359 hsa-miR-20b_st 8.274423854 7.613606136 6.318724325 5.879053758 hsa-miR-20b-star_st 4.380467375 4.965599058 5.053830912 5.507004938 hsa-miR-448_st 1.995628867 2.119403855 3.636178743 1.537743409 hsa-miR-429_st 4.820608628 5.59110814 3.147367772 1.944800267 hsa-miR-449a_st 3.222327366 3.241181082 2.242788242 2.976664367 hsa-miR-450a_st 2.650953631 3.024833537 3.032072806 1.866581529 hsa-miR-431_st 2.491821857 2.382569236 2.988633765 2.55059584 hsa-miR-431-star_st 6.237746627 6.395154153 6.366077539 6.752372148 hsa-miR-433_st 4.136946105 4.660273768 4.802417626 4.354328356 hsa-miR-329_st 2.746620613 2.557765836 2.076494177 2.898824993 hsa-miR-451_st 13.68172624 12.75740874 7.012489589 11.30509166 hsa-miR-452_st 5.693101949 5.940767331 6.356139299 5.429315621 hsa-miR-452-star_st 4.004729801 3.20726597 3.286230278 3.87379775 hsa-miR-409-5p_st 3.283946497 3.21905172 3.518976638 3.598641862 hsa-miR-409-3p_st 5.490975536 5.615373048 5.252184952 5.155386837 hsa-miR-412_st 3.910187307 4.358637998 5.938048937 4.127117412 hsa-miR-410_st 3.401374867 3.102593357 2.564069511 3.148024967 hsa-miR-376b_st 2.037331802 1.633547686 2.109034746 1.384231192 hsa-miR-483-5p_st 11.48697621 11.14013436 11.79228324 12.10165268 hsa-miR-483-3p_st 7.015955269 6.672237311 7.6947126 7.117736593 hsa-miR-484_st 7.179139789 7.628582821 6.314937919 6.491440502 hsa-miR-485-5p_st 5.865033827 6.043636579 6.278040564 6.186079495 hsa-miR-485-2p_st 5.040404224 5.191017249 6.33382879 6.544911556 hsa-miR-486-5p_st 9.945133767 8.216680029 6.626558893 8.443564606 hsa-miR-486-3p_st 10.30725446 9.745482622 10.32434641 10.91720717 hm-miR-487a_st 4.950546283 5.352456447 5.022346627 5.099229098 hsa-miR-488-star_st 2.101418594 1.736782612 2.192048811 2.074310116 hsa-miR-488_st 2.385195266 1.84629391 0.522412748 0.793672075 hsa-miR-489_st 7.224259227 8.487167896 9.392607614 9.221319953 hsa-miR-490-5p_st 6.287414241 6.712714336 7.789732604 7.747411863 hsa-miR-490-3p_st 3.957729018 4.529561833 6.269429331 5.156304206 hsa-miR-491-5p_st 9.14801115 9.119533094 9.360999042 9.331565902 hsa-miR-491-3p_st 4.161097073 5.101786149 5.183513981 4.999811428 hsa-miR-511_st 0.702313416 0.714146383 −0.243418908 0.079447355 hsa-miR-146b-5p_st 9.015522352 9.152902899 6.340359326 5.681079655 hsa-miR-146b-3p_st 3.403523326 4.319334342 3.034035011 3.942033319 hsa-miR-202-star_st −0.408710262 −1.224903335 −0.325593377 −0.997067698 hsa-miR-202_st 8.173654613 8.586726092 9.217224764 8.8184631738 hsa-miR-492_st 7.688090156 7.704359996 9.062426003 9.102016572 hsa-miR-493-star_st 3.162219739 3.170230452 2.76910378 2.59678215 hsa-miR-493_st 4.465152523 5.02433445 5.736822861 5.478322642 hsa-miR-432_st 6.572573183 6.739568851 6.781156057 7.532411502 hsa-miR-432-star_st 4.330503177 5.03034875 5.436058465 5.239478042 hsa-miR-494_st 14.75246457 15.01578591 15.17287543 16.10271.852 hsa-miR-495_st 2.677284625 2.394071447 1.957841643 1.519621597 hsa-miR-496_st 1.491130997 1.675203096 2.141256899 1.53866506 hsa-miR-193b-star_st 11.57881434 11.22118542 11.9356515 12.12750837 hsa-miR-193b_st 8.722490265 7.933249019 6.011209961 6.252612011 hsa-miR-497_st 9.880786896 8.888758093 6.690177723 7.151218198 hsa-miR-497-star_st 2.728169727 2.519892129 1.45478758 1.511959166 hsa-miR-181d_st 9.546893657 9.474112716 7.490449476 8.190783076 hsa-miR-512-5p_st 3.610445142 4.250914414 5.70436943 5.019476144 hsa-miR-512-3p_st 4.613123718 4.549653388 4.641703368 4.769113756 hsa-miR-498_st 11.37241328 11.06065387 11.73356668 12.09446051 hsa-miR-520e_st 1.271983135 1.294041938 −0.268031871 1.060488617 hsa-miR-515-5p_st 2.306234144 1.928544491 1.402261236 1.743039617 hsa-miR-515-3p_st 2.363556379 3.539060893 3.713444648 2.648821267 hsa-miR-519e-star_st 4.976779173 6.234375268 6.044391889 6.306589474 hsa-miR-519e_st 3.968351439 3.840298188 3.171937727 3.235211346 hsa-miR-520f_st 0.6762583.57 1.89807052 −0.811860466 0.887527051 hsa-miR-519c-5p_st 4.55929431 5.018043301 6.153401371 6.768684196 hsa-miR-519c-3p_st 0.362559732 0.295886916 −0.028172323 0.607261925 hsa-miR-520a-5p_st 2.858531648 3.719555849 4.97524749 4.02941409 hsa-miR-520a-3p_st 2.216029214 2.164579655 1.88957143 1.718621096 hsa-miR-526b_st 4.512010262 5.05462741 5.432868216 6.171072749 hsa-miR-526b-star_st 1.024741198 1.279532309 0.222092606 0.745519221 hsa-miR-519b-5p_st 5.688749288 5.348697266 6.51157094 7.042383186 hsa-miR-519b-3p_st 1.56291148 1.77313865 0.566468504 1.52256108 hsa-miR-525-5p_st 4.630508828 5.476751421 6.071568336 6.347440019 hsa-miR-525-3p_st 3.044225068 2.49581343 3.317340452 3.103063132 hsa-miR-523-star_st 4.75883717 4.549634758 6.577608902 7.095216182 hsa-miR-523_st 1.257382437 1.608987536 −0.03852437 1.966963204 hsa-miR-518f-star_st 5.222288263 6.351974543 6.204044626 6.484032146 hsa-miR-518f_st 1.333105212 1.069308819 0.461487661 1.258275453 hsa-miR-520b_st 1.265926491 1.370427544 0.11123631 1.144638543 hsa-miR-518b_st 3.626783705 3.842392906 4.182290718 3.907051147 hsa-miR-526a_st 5.040739311 6.01758759 6.419561853 7.648065313 hsa-miR-520c-5p_st 4.2371028 5.856593262 6.884801142 7.250926877 hsa-miR-520c-3p_st 3.379730618 3.558563779 2.195875869 2.89079991 hsa-miR-518c-star_st 7.788806025 8.255909544 8.997885104 9.251760045 hsa-miR-518c_st 0.69110614 0.098388841 −0.734749822 0.809050159 hsa-miR-524-5p_st 3.558902371 5.01547627 5.577985611 5.351318587 hsa-miR-524-3p_st 3.332175704 2.969925085 3.49591154 3.542643801 hsa-miR-517-star_st 3.881761665 4.972207769 5.828180436 5.099171501 hsa-miR-517a_st 1.142142988 1.77643191 1.455968132 4.03594404 hsa-miR-519d_st 3.445149798 5.176889255 3.77663282 4.674648426 hsa-miR-521_st 3.162040426 2.839665167 2.431095553 2.761564039 hsa-miR-520d-5p_st 5.099609202 5.915113675 6.949657545 6.505307004 hsa-miR-520d-3p_st 4.216808958 4.934183662 5.612221069 5.75567015 hsa-miR-517b_st 2.425572566 3.23432469 2.962888503 4.842949335 hsa-miR-520g_st 1.434258799 2.983828657 2.36649476 3.356506828 hsa-miR-516b_st 6.068500901 7.048631664 7.232776266 7.859808933 hsa-miR-516b-star_st 2.977201837 2.828689965 2.270424765 2.364534038 hsa-miR-518e-star_st 5.710663209 5.621366618 6.736633271 7.28636198 hsa-miR-518e_st 1.939216552 1.979057411 0.582926368 2.534633473 hsa-miR-518a-5p_st 5.484250927 6.400779521 7.334769917 7.987066618 hsa-miR-518a-3p_st 2.61962248 3.114159375 3.127147536 3.957343392 hsa-miR-518d-5p_st 4.957013741 6.168347881 6.993936988 7.426922315 hsa-miR-518d-3p_st 2.569767115 2.464411534 2.707356601 2.869206938 hsa-miR-517e_st 0.346296634 0.469967149 0.457766473 1.5685395 hsa-miR-520h_st 2.086135675 2.294451586 2.886149924 2.772852027 hsa-miR-522-star_st 4.753812187 5.334628514 5.493407302 7.154470214 hsa-miR-522_st 2.570990253 2.257011602 2.058867451 3.2376085 hsa-miR-519a-star_st 4.70277895 4.871011474 6.06749863 6.455096822 hsa-miR-519a_st 1.185992184 0.9788824 −0.092276397 1.86904505 hsa-miR-527_st 6.202731154 6.611320914 7.978549152 8.079381.615 hsa-miR-516a-5p_st 5.988111823 6.58292372 7.620995211 8.046510697 hsa-miR-516a-3p_st 2.955268253 2.155749326 1.752678801 2.069355666 hsa-miR-499-5p_st 2.211139301 2.087048811 0.201791451 1.289218943 hsa-miR-499-3p_st 2.760633389 2.357884381 2.209156671 1.563268224 hsa-miR-500_st 6.181665756 5.952074625 4.773930114 4.469984509 hsa-miR-500-star_st 9.030920841 8.538077287 8.353384809 8.141336827 hsa-miR-501-5p_st 5.396947659 5.675229931 4.839233686 5.810843576 hsa-miR-501-3p_st 8.106901495 8.273116305 8.47027712 8.678756618 hsa-miR-502-5p_st 3.761496028 3.867682178 2.62117773 3.111313633 hsa-miR-502-3p_st 8.435697346 8.477783091 7.521004192 7.634626573 hsa-miR-503_st 10.61366553 9.865656289 11.01753547 10.83829654 hsa-miR-504_st 5.360727245 5.236806635 5.724072832 5.64046857 hsa-miR-505-star_st 6.932005194 7.049431265 7.414575416 7.008814896 hsa-miR-505_st 4.55828447 5.130852067 3.357976966 2.248955283 hsa-miR-513a-5p_st 12.1046364 12.66112211 13.19600086 13.79723245 hsa-miR-513a-3p_st 1.001508234 0.36826761 0.200083112 0.890134052 hsa-miR-506_st 3.586773699 3.456770276 4.080674828 3.37322638 hsa-miR-507_st 0.82044249 0.511013834 0.803892662 1.567600221 hsa-miR-508-5p_st 7.771968922 7.999130437 8.619456195 9.18480847 hsa-miR-508-3p_st −0.429103682 0.306943741 −0.322930801 −0.838581445 hsa-miR-509-5p_st 3.582480146 4.423614723 5.188919685 5.049664757 hsa-miR-509-3p_st 4.622828296 4.813708522 4.679440173 4.796024154 hsa-miR-510_st 7.328737291 7.70738716 8.680082646 8.704086925 hsa-miR-514_st 1.517871415 0.970357311 0.008882164 1.07072062 hsa-miR-532-5p_st 8.04219745 7.654205403 6.731118346 6.429236403 hsa-miR-532-3p_st 8.088159085 7.765646662 6.932990305 7.234312748 hsa-miR-455-5p_st 3.360490025 2.878159212 2.341931082 1.79726567 hsa-miR-455-3p_st 8.784896906 7.876516996 5.796970324 6.835533264 hsa-miR-539_st 3.319843346 3.021805043 3.240219606 2.662709981 hsa-miR-544_st 0.610179798 0.055713025 0.353780267 0.470410288 hsa-miR-545-star_st 0.878761813 1.366812241 1.433002819 1.398577412 hsa-miR-545_st 1.417327023 0.848667315 −0.469400152 0.685363067 hsa-miR-487b_st 6.229736949 7.131982957 7.012964999 6.107746135 hsa-miR-551a_st 3.810754317 3.444889898 4.467543844 3.855289781 hsa-miR-552_st 3.548337305 4.219585302 6.620574711 4.315280695 hsa-miR-553_st 2.717037555 2.50042178 1.236581881 2.015763555 hsa-miR-554_st 4.079876404 4.351764039 5.486304696 4.54855859 hsa-miR-92b-star_st 15.25687132 14.51975526 14.24544199 15.43594874 hsa-miR-92b_st 9.448707813 9.024157953 8.521543981 8.417767394 hsa-miR-555_st 3.303768932 3.39716382 3.547694409 3.860847964 hsa-miR-556-5p_st 1.7058265/5 0.901111201 −0.08062856 0.060370126 hsa-miR-556-3p_st 0.888064703 1.007056819 1.287607208 1.122278349 hsa-miR-557_st 12.15429565 11.7510164 12.44979903 12.59507443 hsa-miR-558_st 0.99008644 1.02821929 1.666709879 0.443088246 hsa-miR-559_st 1.573919842 0.977742479 1.270535961 2.036913442 hsa-miR-561_st 1.327771814 0.354692286 −0.252898983 0.374073519 hsa-miR-562_st 1.518323396 1.1865286 0.92061375 12.31612962 hsa-miR-563_st 2.366869458 2.057381088 2.564706102 1.942708993 hsa-miR-564_st 11.70682995 11.92451583 12.18794141 12.62466832 hsa-miR-566_st 7.556852398 6.901466031 6.725504249 7.034973361 hsa-miR-567_st 3.222862586 3.210992352 2.410976448 2.929558822 hsa-miR-568_st 0.821082826 0.697107064 0.601235793 1.808933599 hsa-miR-551b-star_st 10.491309 10.58412643 10.89387543 10.89588663 hsa-miR-551b_st 2.100430676 2.891180147 0.718002497 1.671583047 hsa-miR-569_st 2.498686023 2.243654785 1.372552073 2.561962106 hsa-miR-570_st 1.781283916 1.696051832 1.535931251 1.349462665 hsa-miR-571_st 3.963162148 4.132617125 3.019950301 3.034975685 hsa-miR-572_st 14.43182634 13.71088503 14.2457319 14.88966559 hsa-miR-573_st 1.169562209 1.017935318 0.852214036 0.346158858 hsa-miR-574-5p_st 7.811959857 7.98916159 7.878216552 7.772829319 hsa-miR-574-3p_st 10.16348091 9.453413187 7.237664895 9.105149162 hsa-miR-575_st 12.53841855 12.51675986 12.92647795 13.53376601 hsa-miR-576-5p_st 2.959168927 2.988904507 3.890220935 2.82754008 hsa-miR-576-3p_st 4.61167322 4.443105867 3.999404885 3.63794014 hsa-miR-577_st 0.397892873 0.608677929 0.717954196 0.639014922 hsa-miR-578_st 2.986800913 3.012545428 2.119884786 2.449467327 hsa-miR-579_st 1.996007301 1.68293746 0.789697177 2.369853703 hsa-miR-580_st 1.518864571 1.171931991 1.192003735 1.31445676 hsa-miR-581_st −0.009483798 0.220997198 0.103549424 0.124103514 hsa-miR-582-5p_st 0.866582877 0.830708181 1.087744659 0.019599761 hsa-miR-582-3p_st 2.804606468 2.644514108 2.154790439 2.289700181 hsa-miR-583_st 4.4781731989 5.479572088 6.882908902 6.87822049 hsa-miR-584_st 6.644179071 7.104145107 7.548949577 7.402872696 hsa-miR-585_st 3.158587512 3.165437498 3.147818657 2.985731738 hsa-miR-548a-3p_st 1.596364318 1.280390342 0.132761099 −0.335731056 hsa-miR-586_st 2.344988904 1.728708548 0.48216527 1.825982972 hsa-miR-587_st 2.086996148 3.103481595 2.984174143 3.125139244 hsa-miR-548b-5p_st 3.465767147 2.722024623 2.403642792 1.566159523 hsa-miR-548b-3p_st 2.043194018 2.543230261 1.033817391 1.495422227 hsa-miR-588_st 4.943891068 4.805973606 4.345704292 5.270198861 hsa-miR-589_st 2.739390334 3.948850954 3.903403608 2.3832335 hsa-miR-589-star_st 4.500657837 4.823910282 −5.707038982 5.314492845 hsa-miR-550_st 10.66826656 11.3973578 12.21595233 12.28480266 hsa-miR-550-star_st 3.714581867 4.884868474 5.142945638 4.334713003 hsa-miR-590-5p_st 1.98745085 1.936296236 1.781864558 0.77192895 hsa-miR-590-3p_st 0.220784646 1.087278605 0.698480139 0.807890324 hsa-miR-591_st 2.506993096 2.230807199 2.955099903 1.916071265 hsa-miR-592_st 0.856312933 0.503674622 0.681908324 0.914049708 hsa-miR-593-star_st 7.523822906 8.565775959 9.330630646 9.46260744 hsa-miR-593_st 5.659663898 5.951821439 5.07649263 4.919194593 hsa-miR-595_st 7.082613683 7.148557786 7.353500516 7.052813346 hsa-miR-596_st 8.109116874 7.910067374 8.332356726 8.524722219 hsa-miR-597_st 1.031983187 1.033526899 1.520749238 1.083128096 hsa-miR-598_st 5.527440081 6.129854325 4.138866681 4.490006912 hsa-miR-599_st 1.752546588 1.08583459 0.137668964 0.560388914 hsa-miR-548a-5p_st 4.651150278 4.10266644 2.776504015 3.432013932 hsa-miR-600_st 4.371316783 4.788674785 6.516436231 5.384855557 hsa-miR-601_st 5.330621343 5.738662546 6.199343069 6.219808196 hsa-miR-602_st 13.85687299 13.20154422 13.99376486 14.5311121 hsa-miR-603_st 1.200987355 1.569354372 0.624070025 0.764590817 hsa-miR-604_st 8.250573194 8.734633676 8.716558006 8.912973539 hsa-miR-605_st 4.762110098 5.451833299 7.021082306 5.597642095 hsa-miR-606_st 1.956299706 1.465643263 1.459278287 1.620299621 hsa-miR-607_st 2.775308709 2.011249011 1.580127315 1.535594714 hsa-miR-608_st 9.526159938 9.39345738 10.05676087 10.07620903 hsa-miR-609_st 2.676169118 2.081134797 2.070836211 3.228669955 hsa-miR-610_st 4.442368862 4.302014088 5.46768961 4.786566398 hsa-miR-611_st 7.676732242 7.214564104 8.16685875 8.565322 hsa-miR-612_st 11.28493978 11.40116443 12.37190388 12.59802188 hsa-miR-613_st 3.626478649 4.302167609 3.554477082 3.398286727 hsa-miR-614_st 4.899056394 5.14676756 6.314433096 6.566224485 hsa-miR-615-5p_st 10.70528033 10.49117366 11.25971341 11.50707402 hsa-miR-615-3p_st 7.061438593 6.919840213 6.809181541 7.582428254 hsa-miR-616-star_st 3.925541918 4.23459399 3.785917853 3.145642082 hsa-miR-616_st 7.393772862 7.591586629 8.231298975 7.415244839 hsa-miR-548c-5p_st 8.5613925861 7.832850048 4.691005635 3.829045136 hsa-miR-548c-3p_st 0.736443408 0.546496528 −0.588414441 −0.436561068 hsa-miR-617_st 4.803263515 5.813230395 7.545030169 5.023409312 hsa-miR-618_st 2.798379037 2.536342891 3.042670049 1.748360898 hsa-miR-619_st 3.701312525 3.815113951 3.806825073 3.107222527 hsa-miR-620_st 2.242724989 2.110160229 3.442336134 2.930335488 hsa-miR-621_st 3.321457023 3.137499425 4.800835983 2.618824186 hsa-miR-622_st 7.984455635 8.776017804 9.076905618 9.158094544 hsa-miR-623_st 9.122791966 8.982954985 9.336689173 9.604868556 hsa-miR-624-star_st 4.008527721 3.335362819 2.977009647 3.438746624 hsa-miR-624_st 3.033924569 2.753069575 2.551250032 2.824142589 hsa-miR-625_st 6.96091631 6.89362271 7.358124032 6.597953836 hsa-miR-625-star_st 3.363817431 3.23553708 3.971467473 3.279300369 hsa-miR-626_st 1.818829098 1.774383519 1.121493213 1.746503401 hsa-miR-627_at 1.643651941 1.429134668 0.01527961 −0.226278232 hsa-miR-628-5p_st 2.767676762 1.830261519 1.213993981 1.671852923 hsa-miR-628-3p_st 8.84914342 9.325776414 11.0997708. 9.765209158 hsa-miR-629_st 7.461767261 7.563889839 6.988666557 7.343668188 hsa-miR-629-star_st 4.847277296 5.259245462 5.556362691 5.028311772 hsa-miR-630_st 5.626814971 6.479810631 7.82364249 7.039566349 hsa-miR-631_st 5.748364171 6.125445177 6.901221164 6.662426692 hsa-miR-33b_st 1.509508535 0.597724381 0.1115375055 0.483613654 hsa-miR-33b-star_st 6.213020706 6.597048611 6.633265095 7.139089388 hsa-miR-632_st 3.283328448 3.986108139 4.302072377 3.124612602 hsa-miR-633_st 1.678200227 1.243106048 1.755430508 2.247671028 hsa-miR-634_st 5.16327607 5.539080519 6.163966823 5.862631655 hsa-miR-635_st 4.499166082 4.904284167 5.075898545 5.087467107 hsa-miR-636_st 9.649983122 8.957490053 9.710756198 9.955664693 hsa-miR-637_st 12.70648413 12.2219657 13.1203992 13.34664817 hsa-miR-638_st 16.82583215 15.68760048 15.33503592 16.35842034 hsa-miR-639_st 8.686046313 8.806347295 9.225462631 9.674096305 hsa-miR-640_st 6.406036892 6.517050896 7.235019894 6.770630498 hsa-miR-641_st 3.061321722 3.210692345 3.105240992 3.024443534 hsa-miR-642_st 2.833885529 3.110872839 2.57091629 2.966592075 hsa-miR-643_st 0.864443095 2.1863099 2.687478297 2.303251861 hsa-miR-644_st 2.090300639 2.48190247 0.262453437 0.8952705 hsa-miR-645_st 2.530746232 2.683701611 2.689088189 1.513029116 hsa-miR-646_st 3.397822452 2.941166876 2.384898604 3.321528582 hsa-miR-647_st 4.003560464 6.188915448 5.448412248 4.754702836 hsa-miR-648_st 7.335062637 7.712786623 8.528042054 8.021695799 hsa-miR-649_st 3.67971451 4.198223404 3.090713694 3.668543956 hsa-miR-650_st 10.1481418 9.474639965 10.25182582 10.57492613 hsa-miR-651_st 0.445277076 1.053738486 1.05086477 0.605013171 hsa-miR-652_st 7.949560485 7.853109136 6.582726191 6.645879685 hsa-miR-548d-5p_st 7.360267394 6.658029445 2.990819369 4.001901958 hsa-miR-548d-3p_st 1.994773664 2.16081734 0.983842672 0.875984184 hsa-miR-661_st 7.44540529 7.253284372 7.11020542 7.369940684 hsa-miR-662_st 6.034252134 6.093382182 6.122712094 6.513324242 hsa-miR-663_st 16.5934618 15.42423353 15.33625634 16.24447672 hsa-miR-449b_st 4.797141722 4.79909231 4.58595706 4.672664052 hsa-miR-449b-star_st 7.857283601 7.848662638 8.216760343 8.506307971 hsa-miR-653_st 1.106907123 0.256644068 2.325152193 0.438370826 hsa-miR-411_st 3.335691735 2.967234747 2.759995351 2.973115051 hsa-miR-411-star_st 3.715134428 3.821225916 3.870658719 3.850245308 hsa-miR-654-5p_st 10.15895553 10.6489257 11.5110892 12.33782824 hsa-miR-654-3p_st 3.661695204 5.619365951 4.816144494 3.000416362 hsa-miR-655_st 0.906080776 0.718999725 0.067276738 0.146702674 hsa-miR-656_st 3.099123522 2.173228154 3.269099496 1.543781571 hsa-miR-549_st 2.467652829 2.21387869 2.787928792 2.33283136 hsa-miR-657_st 3.724109369 3.682879335 5.076183796 3.923230815 hsa-miR-658_st 12.19377733 11.77696576 12.28022453 12.8377025 hsa-miR-659_st 10.44708232 10.43430391 11.0251027 11.26107126 hsa-miR-660_st 7.114293509 6.625166558 4.914623022 5.01971782 hsa-miR-421_st 6.107800551 6.267098582 5.654146122 4.939031495 hsa-miR-542-5p_st 7.377661175 7.523626465 7.206159892 7.754228592 hsa-miR-542-3p_st 4.69734634 5.66580513 5.96380632 5.56620297 hsa-miR-758_st 2.450277501 2.570506438 3.1715716 1.325962266 hsa-miR-1264_st 2.332774695 2.098542415 1.93800895 2.120349242 hsa-miR-671-5p_st 11.4532377 11.06728759 11.55459236 12.20431395 hsa-miR-671-3p_st 5.868324251 6.769824161 7.404163047 7.06378556 hsa-miR-668_st 8.102091255 8.427992362 9.077610623 9.134023394 hsa-miR-767-5p_st 2.579006794 2.754504547 2.003248059 2.947028227 hsa-miR-767-3p_st 1.965860018 2.350472892 3.027868983 1.966075806 hsa-miR-1224-5p_st 13.05045054 12.74162752 13.6112501 13.73720261 hsa-miR-1224-3p_st 5.249762161 5.358271898 7.090449559 5.46927206 hsa-miR-320b_st 12.06436497 11.45217194 10.63174016 10.92937027 hsa-miR-320c_st 11.66249355 10.71003057 9.78356249 10.15481048 hsa-miR-1296_st 6.828462317 6.197309016 7.420111805 6.421199534 hsa-miR-1468_st 4.919981554 5.463877754 6.877835487 6.221438866 hsa-miR-1323_st 7.304856542 7.772463463 7.999766605 8.488849167 hsa-miR-1271_st 6.05405897 6.619878747 6.794560279 6.270065049 hsa-miR-1301_st 7.197210379 7.90420429 7.946110036 7.880225706 hsa-miR-454-star_st 2.144625725 1.712211583 1.499354102 1.61798444. hsa-miR-454_st 3.964494136 4.960265049 2.591447474 1.065389007 hsa-miR-1185_st 1.151554229 1.032298365 0.412654372 0.224122481 hsa-miR-449c_st 5.959341131 6.395147941 7.772084379 7.396201984 hsa-miR-449c-star_st 3.71277301 3.96095334 4.557226471 4.575132331 hsa-miR-1283_st 1.915133717 2.303974627 3.389586864 2.566177153 hsa-miR-769-5p_st 6.371491588 7.167932566 6.760065421 6.391929608 hsa-miR-769-3p_st 9.547719104 9.439108531 10.32388326 10.44138785 hsa-miR-766_st 7.339629768 7.523930737 7.971647646 7.700352376 hsa-miR-762_st 16.76868616 15.6041217 15.33720724 16.34358027 hsa-miR-802_st 1.080486387 0.391286922 0.512161962 0.679653059 hsa-miR-670_st 4.222012993 4.701603256 4.130291807 4.64576156 hsa-miR-1298_st 3.229934102 4.000206453 4.872480826 3.259557889 hsa-miR-2113_st 4.801006816 5.521521473 5.088639255 5.440513025 hsa-miR-761_st 7.020354487 7.276838509 7.91447577 8.272703255 hsa-miR-764_st 5.119055355 5.978268059 6.567472495 5.979927114 hsa-miR-759_st 1.198727868 1.198186082 0.907009283 1.449717547 hsa-miR-765_st 8.725017911 9.145093167 9.697710346 9.625867139 hsa-miR-770-5p_st 6.235127247 6.771835188 7.276804581 7.000849746 hsa-miR-675_st 13.62609191 12.76832827 13.67923956 13.99321113 hsa-miR-675-star_st 7.272125734 6.925201712 7.899073782 8.337199696 hsa-miR-298_st 9.852365218 10.18389802 10.64209271 11.03798492 hsa-miR-891a_st 5.817426468 5.770974993 7.229102928 6.084532474 hsa-miR-300_st 4.764690634 4.767748344 5.451135946 5.901921162 hsa-miR-886-5p_st 12.70950005 11.83542348 12.06637747 12.51293883 hsa-miR-886-3p_st 11.14869336 10.30518738 9.210951617 9.915750803 hsa-miR-892a_st 2.636830189 4.017622897 5.472504169 4.560156529 hsa-miR-220c_st 3.379918141 3.50429268 3.973960106 3.414552275 hsa-miR-450b-5p_st 0.328948416 0.046942734 0.162292995 0.625735886 hsa-miR-450b-3p_st 0.984425175 0.737770107 0.051873416 0.591649314 hsa-miR-874_st 11.90706167 11.76221816 12.35629337 12.91327086 hsa-miR-890_st 4.389964436 5.523298561 7.073328483 5.176748711 hsa-miR-891b_st 2.746131046 2.662836578 1.815137697 2.622007111 hsa-miR-220c_st 4.817604743 6.263178844 6.512521322 5.396386738 hsa-miR-888_st 1.781695783 1.585274458 1.658933193 0.88584169 hsa-miR-888-star_st 0.916043305 1.069958076 0.914226168 0.838247206 hsa-miR-892b_st 3.469869279 3.904086945 4.29455937 2.838950513 hsa-miR-541-star_st 6.359838087 6.221440777 6.242503547 6.510524164 hsa-miR-541_st 7.707957871 8.087011184 8.480149195 8.693805869 hsa-miR-889_st 1.578287762 1.046492892 2.086323564 1.937226347 hsa-miR-875-5p_st 0.315608033 0.706653686 4.139245494 0.535795599 hsa-miR-875-3p_st 2.999220755 2.729779235 2.155760224 3.435552947 hsa-miR-876-5p_st 0.03863183 -0.304959898 0.403996083 0.480722016 hsa-miR-876-3p_st 1.373732646 1.442643055 0.983839486 1.071856781 hsa-miR-708_st 7.239197915 6.835198868 6.483775913 4.722705328 hsa-miR-708-star_st 3.849764031 3.866066809 3.580852098 2.892062786 hsa-miR-147b_st 3.914269803 3.870121614 4.771212594 4.056059076 hsa-miR-190b_st 0.633446086 1.076370957 0.775052509 −0.249151231 hsa-miR-744_st 14.70217707 14.20123681 14.96715719 15.58817853 hsa-miR-744-star_st 3.713698066 3.758788685 4.554413642 4.350294361 hsa-miR-885-5p_st 7.172481189 7.341928357 8.649609276 7.821084222 hsa-miR-885-3p_st 14.09623533 13.2666511 13.95380378 14.39408241 hsa-miR-877_st 11.93586796 11.70879748 12.33726818 12.50737987 hsa-miR-877-star_st 7.277016312 6.390417395 7.83670507 7.201516652 hsa-miR-887_st 8.8331618694 8.449282294 9.33228137 9.396635569 hsa-miR-665_st 12.45853312 12.06068253 12.41395325 12.68316187 hsa-miR-873_st 4.272598796 4.193212241 4.251622638 4.019190514 hsa-miR-543_st 3.708955709 3.3480405 3.83803881 4.102454384 hsa-miR-374b_st 6.048632241 5.787739384 3.872193699 2.758113275 hsa-miR-374b-star_st 1.545771098 1.327410017 0.562223604 1.262982618 hsa-miR-760_st 10.67016869 10.30453529 10.74309848 11.29343081 hsa-miR-301b_st 0.004172902 1.134541019 1.236881731 -0.108888319 hsa-miR-216b_st 4.017565261 3.428607839 3.649467597 2.877467589 hsa-miR-208b_st 2.664578067 2.8389751 0.910518462 1.753974803 hsa-miR-920_st 10.26048059 10.02648387 10.80713868 11.06642267 hsa-miR-921_st 10.25497246 10.74968211 11.75043863 11.89166336 hsa-miR-922_st 4.509270408 5.233178939 6.277185644 5.983522058 hsa-miR-924_st 2.019863486 2.19707223 3.002759242 0.748347347 hsa-miR-509-3-5p_st 5.606708197 6.223341462 7.805786002 5.637988843 hsa-miR-933_st 10.96044315 10.55859856 10.64715278 10.79824735 hsa-miR-934_st 3.354013522 3.46976687 3.189667527 3.81129798 hsa-miR-935_st 6.678257946 6.45936146 7.548521133 7.344681574 hsa-miR-936_st 10.12298367 10.17478509 10.7359425 10.91971242 hsa-miR-937_st 4.240432727 4.893285672 5.720364603 4.553469406 hsa-miR-938_st 3.91172587 4.345856717 5.334771867 4.442201953 hsa-miR-939_st 13.53649246 13.04497356 13.50054334 14.15250009 hsa-miR-940_st 8.26629469 7.917507393 9.077161476 8.892749052 hsa-miR-941_st 5.14039694 5.401732722 5.317688737 5.557745712 hsa-miR-942_st 1.746705837 1.697845435 1.638036919 0.782667492 hsa-miR-943_st 8.133539192 7.806899416 8.663679447 8.567512531 hsa-miR-944_st 1.760020567 1.4865282 −0.426772601 1.545835088 hsa-miR-297_st 4.090194732 5.95594855 4.212958805 3.933114008 hsa-miR-1178_st 3.583097511 3.829677464 4.728832479 4.162261373 hsa-miR-1179_st 1.499578099 1.668009207 −0.240283308 0.71332853 hsa-miR-1180_st 9.7896753781 9.451569101 9.367611923 10.16423389 hsa-miR-1181_st 10.01447497 9.601251221 10.02537281 10.09593038 hsa-miR-1182_st 10.7606795 10.50515791 11.33452074 11.24237013 hsa-miR-1183_st 10.3242268 10.67532292 11.04819082 11.04137448 hsa-miR-1184_st 3.711344923 4.269689798 4.231342595 4.182820617 hsa-miR-1225-5p_st 14.11053686 13.70917522 14.24746333 14.88474749 hsa-miR-1225-32p_st 7.991840582 7.785029773 8.582877853 8.680460756 hsa-miR-1226-star_st 11.02877444 10.72178519 11.45018231 11.79218749 hsa-miR-1226_st 5.700582042 5.744766534 7.0405091 6.242981796 hsa-miR-1227_st 5.419469141 5.198321665 6.021184152 5.665351209 hsa-miR-1228-star_st 16.70998293 15.55700397 15.33610805 16.29285962 hsa-miR-1228_st 8.154115643 8.05923496 8.284488649 8.878458863 hsa-miR-1229_st 8.03656271 7.605598641 8.315984806 7.609823243 hsa-miR-1231_st 14.21257807 13.63274086 14.38096772 14.78253075 hsa-miR-1233_st 7.17634291 6.918075954 7.521408561 7.823261022 hsa-miR-1234_st 6.838286834 6.80815887 7.585403874 7.017561509 hsa-miR-1236_st 5.841932948 5.717808985 6.363944409 5.551508776 hsa-miR-1237_st 7.99816422 8.096619309 8.139073365 8.61766465 hsa-miR-1238_st 6.806674748 7.019020562 7.852386277 7.015796807 hsa-miR-1200_st 4.60755795 5.354495868 5.087865523 5.090030192 hsa-miR-1201_st 7.928667307 7.927733969 7.372510068 6.824235646 hsa-miR-1202_st 13.06650356 12.92261707 13.72162959 14.04562654 hsa-miR-1203_st 8.216345523 8.469704043 8.921408438 8.929213375 hsa-miR-663b_st 10.08383 9.73883975 10.8925643 10.97017249 hsa-miR-1204_st 4.89894805 5.088187073 4.726236643 5.184858194 hsa-miR-1205_st 3.342607697 3.657960242 3.133278231 3.21001883 hsa-miR-1206_st 0.912534017 0.715262617 −0.781103034 0.337732972 hsa-miR-1207-5p_st 15.46101297 14.73993958 14.96362568 15.62123855 hsa-miR-1207-3p_st 3.904235798 3.872213017 4.314777158 3.971824924 hsa-miR-1208_st 8.35520478 8.416007134 9.709637838 9.475237418 hsa-miR-548e_st 0.46241271 0.39142689 1.017450221 0.461710119 hsa-miR-548j_st 3.361188914 3.292840372 3.921747375 2.451554908 hsa-miR-1285_st 13.01632775 12.8823899 12.43062011 12.99252508 hsa-miR-1286_st 7.72852305 8.445567843 9.230146776 8.834770442 hsa-miR-1287_st 5.471271745 5.960019992 6.681396732 5.853883448 hsa-miR-1289_st 4.56369306 4.963962371 3.695735726 3.225426247 hsa-miR-1290_st 9.679564994 9.129036839 9.398244283 9.307488772 hsa-miR-1291_st 8.168479109 8.358091441 9.22049167 8.296236635 hsa-miR-548k_st 2.197201364 2.325718735 1.490168219 2.353650507 hsa-miR-1293_st 7.631046340 7.669139533 8.11335445 8.466871205 hsa-miR-1294_st 5.436385596 5.959692915 5.561478995 5.133624265 hsa-miR-1295_st 5.297172118 5.500607795 6.896104851 6.733670936 hsa-miR-1297_st 0.724144921 1.169591166 0.330944799 -0.496106028 hsa-miR-1299_st 5.204375499 5.767106251 4.258952329 4.366795007 hsa-miR-5481_st 4.273381644 4.296765959 2.785056688 3.807303151 hsa-miR-1302_st 1.75649963 1.286548082 3.71112815 2.06904518 hsa-miR-1303_st 10.50497028 10.33983581 10.56147319 10.66925816 hsa-miR-1304_st 5.648867949 6.701391191 7.186285314 7.102162117 hsa-miR-1305_st 2.310964882 2.35679225 2.059400448 1.67784167 hsa-miR-1243_st 3.368599396 2.909771223 2.925218666 3.156172105 hsa-miR-548f_st 1.254985225 0.845929419 1.05633651 0.350027612 hsa-miR-1244_st 7.632693704 8.451290155 7.268389986 8.873274812 hsa-miR-1245_st 3.648606204 2.927243577 2.937517715 3.360656507 hsa-miR-1246_st 13.78938377 13.04291866 13.15280909 12.6537567 hsa-miR-1247_st 6.28046736 6.379706246 7.333077533 7.043184828 hsa-miR-1248_st 9.028266837 9.932013427 9.955835036 10.22919251 hsa-miR-1249_st 4.742773346 4.470797979 5.066666152 4.681310445 hsa-miR-1250_st 8.406365311 8.481852979 8.966489878 9.178783164 hsa-miR-1251_st 4.662359354 4.851673773 3.421764485 3.194277395 hsa-miR-1253_st 4.067602802 4.454960059 5.178877179 4.549201013 hsa-miR-1254_st 10.69293115 10.934926113 11.41367662 12.14160589 hsa-miR-1255a_st 3.917838318 5.4239959 4.425751658 4.609682763 hsa-miR-1256_st 2.980699524 3.107340676 2.729576419 2.11550905 hsa-miR-1257_st 3.33890951 4.006488792 4.102969069 4.177521699 hsa-miR-1258_st 3.697035298 4.244841938 5.035523494 3.605472347 hsa-miR-1259_st 2.219917081 1.698737213 1.411795384 1.236252404 hsa-miR-1260_st 10.75426184 10.61282162 9.540151665 10.20221475 hsa-miR-548g_st 0.961406784 0.154572422 0.016211565 −0.304197401 hsa-miR-1261_st 7.008745335 7.735547252 8.833477227 7.932451799 hsa-miR-1262_st 2.516339214 2.610070218 3.045336382 2.513164148 hsa-miR-1263_st 3.413790905 3.307066474 3.785548065 2.579193679 hsa-miR-548n_st 1.488868639 1.494784413 0.259442315 1.987819487 hsa-miR-548m_st 2.058863636 1.687188637 2.351456914 2.122010686 hsa-miR-1265_st 4.719051244 4.852673648 5.417890945 4.781806321 hsa-miR-548o_st 1.819011213 1.641218643 0.996206023 1.171508815 hsa-miR-1266_st 8.749567976 8.586819418 9.23915796 9.289911436 hsa-miR-1267_st 3.881619018 3.317034777 4.098373022 4.099285048 hsa-miR-1268_st 15.9790372 15.11718597 15.20533578 15.97885655 hsa-miR-1269_st 4.776676915 5.020923709 5.529737932 5.288180901 hsa-miR-1270_st 6.199106888 6.303482794 6.586428453 6.563158996 hsa-miR-1272_st 3.270869025 3.122875308 4.620269657 3.156542523 hsa-miR-1273_st 11.02246563 10.76989738 10.39353704 10.95862079 hsa-miR-1274a_st 9.568747066 10.03465896 9.383120549 9.743879148 hsa-miR-548b_st 3.275704381 2.932913652 1.13343668 0.013115665 hsa-miR-1275_st 14.07330883 13.81655531 14.24148814 14.68065084 hsa-miR-1276_st 5.635431364 5.797376185 7.219162417 6.368853534 hsa-miR-302e_st 2.395226428 2.88511818 2.436093274 3.665971316 hsa-miR-302f_st 1.020223788 1.013751006 1.244476073 1.068236078 hsa-miR-1277_st 2.764665269 1.438185557 1.566373136 1.4.4382788 hsa-miR-548p_st 1.180958451 1.305949463 0.674521162 1.517150123 hsa-miR-548i_st 4.578266987 4.396822381 2.639131646 3.220080058 hsa-miR-1278_st 3.925672707 3.174846046 1.817023541 2.837937964 hsa-miR-1279_st 3.190088856 3.024442755 1.422201255 0.523641598 hsa-miR-12746_st 13.25598939 13.50959829 12.97000789 13.29480599 hsa-miR-1281_st 9.059000565 9.095417735 9.384833818 9.599101646 hsa-miR-1282_st 3.192302676 4.288601151 1.982558325 3.706753823 hsa-miR-1284_st 3.024413459 4.37722344 4.515529492 4.31737603 hsa-miR-1288_st 3.731935286 3.76649828 5.728396309 4.650410363 hsa-miR-1292_st 12.43088819 12.34116862 13.1636083 13.5621493 hsa-miR-1252_st 1.653467614 0.880759235 1.882882368 1.457760139 hsa-miR-1255b_st 7.300654252 8.295850717 7.321072569 7.02013921 hsa-miR-1280_st 15.46704804 14.82832318 14.03923877 14.75703853 hsa-miR-1308_st 14.98486222 15.01417758 14.62676488 14.97388107 hsa-miR-664-star_st 9.993835053 9.712708523 10.18021905 9.777048041 hsa-miR-664_st 5.051341942 5.751036681 5.761666935 5.779450298 hsa-miR-1306_st 6.840617021 7.053952682 7.103387956 7.475237452 hsa-miR-1307_st 14.2941406 13.37617881 14.13392948 1.432507148 hsa-miR-513b_st 9.926543823 10.28739809 11.57297791 11.98510846 hsa-miR-513c_st 8.063941849 9.023749356 9.626994734 9.898204496 hsa-miR-1321_st 7.099585987 7.598151531 8.808100161 8.330093258 hsa-miR-1322_st 3.626969454 3.525184531 3.724091248 3.872489407 hsa-miR-720_st 15.41912763 14.87662038 14.37444695 14.84592235 hsa-miR-1197_st 2.133959742 1.688860402 1.605150748 2.309062372 hsa-miR-1324_st 1.769124533 1.695610846 1.099782949 1.517074083 hsa-miR-1469_st 16.72095847 15.57718604 15.33635317 16.32007345 hsa-miR-1470_st 5.603682335 5.74074909 5.828480765 6.337599843 hsa-miR-1471_st 1.039409495 10.68249991 11.94599153 12.0706761 hsa-miR-1537_st 1.365680003 0.861392991 0.942752856 1.188012555 hsa-miR-1538_st 7.529837108 7.837174942 8.453519663 8.564029327 hsa-miR-1539_st 5.844954457 5.671325275 7.004200358 6.598818739 hsa-miR-103-as_st 2.127161342 2.889842322 2.760745957 2.231528645 hsa-miR-320d_st 10.049061 9.763778363 7.677381821 8.409056802 hsa-miR-1825_st 6.856302384 6.699015439 7.037075726 7.243565051 hsa-miR-1826_st 16.32585487 15.70328241 15.33522687 16.3575971 hsa-miR-1827_st 43.741478428 4.954485077 3.479671646 3.82309643 hsa-miR-1908_st 16.81281513 15.64217652 15.3303654 16.35595952 hsa-miR-1909-star_st 9.119022776 8.92317744 9.330025332 9.411065623 hsa-miR-1909_st 15.12419687 14.40011948 14.93985824 15.42788542 hsa-miR-1910_st 10.20234338 9.926037288 10.61378857 10.64724514 hsa-miR-1911_st 3.145527282 3.184645854 5.130815829 4.107002671 hsa-miR-1911-star_st 4.658075907 5.030702773 4.064546793 5.255819332 hsa-miR-1912_st 4.001384093 3.865746486 3.538355087 4.118885677 hsa-miR-1913_st 8.237616705 7.952887331 8.80795441 8.603837596 hsa-miR-1914_st 6.903125285 7.359554324 6.656591439 6.081670273 hsa-miR-1914-star_st 12.662557 12.55414759 13.07866111 13.78611978 hsa-miR-1915-star_st 7.720172427 7.788545722 8.742783194 8.178105895 hsa-miR-1915_st 16.81079247 15.63888351 15.33533993 16.35558 hsa-miR-1972_st 13.29544678 13.42957619 12.16183818 12.94796176 hsa-miR-1973_st 14.01930413 14.46947987 15.32646231 15.74214039 hsa-miR-1975_st 16.32404312 15 36795277 14.79178069 15 99366727 hsa-miR-1976_st 7.959859616 7.835742095 8.074508458 8.208211194 hsa-miR-1979_st 15.58724906 14.98172603 14.26634492 15.08869296 hsa-miR-2052_st 0.132426186 0.439437169 0.267544675 0.608661$84 hsa-miR-2053_st 1.635318468 1.630887974 0.868080463 2.828516262 hsa-miR-2054_st 0.12102467 −0.794225032 −1.407328249 −0.145001587 hsa-miR-2110_st 10.64853729 10.56131206 11.36224787 11.73149438 hm-miR-2114_st 2.417797389 2.147652852 1.274853735 2.507157259 hsa-miR-2114-star_st 4.979326639 6.024583986 7.102254105 6.954035675 hsa-miR-2115_st 1.975770368 1.701632793 2.369701056 0.825623318 hsa-miR-2115-star_st 7.272849194 7.728794325 9.633485123 8.915777083 hsa-miR-2116_st 4.294566102 5.746923153 6.490850977 5.986766953 hsa-miR-2116-star_st 3.627304794 4.451414431 5.14923881 4.91427796 hsa-miR-2117_st 1.970867356 2.150486173 2.174498923 1.828557754 hsa-miR-548q_st 7.781288274 8.039882909 7.948350835 8.391793027 hsa-miR-2276_st 9.677141282 10.07997224 10.96562624 10.79733286 hsa-miR-2277_st 8.926268827 8.666541945 8.946248836 9.643003749 hsa-miR-2278_st 5.44540097 5.449001332 6.22166905 5.4222975 hsa-miR-711_st 11.33694248 11.33689883 12.33858614 12.54151351 hsa-miR-718_st 7.33468596 7.043672525 8.490981779 7.878328285 hsa-miR-2861_st 16.81757584 15.64957484 15.33661258 16.35623765 hsa-miR-2909_st 3.194000343 2.733268516 2.76760842 2.494159926 hsa-miR-3115_st 2.08057033 1.771668275 1.07413404 1.341353926 hsa-miR-3116_st 5.643945211 5.87107786 6.322297739 6.272952137 hsa-miR-3117_st 2.631995899 2.965426903 2.438042157 3.286417281 hsa-miR-3118_st 2.092779489 1.902207128 3.037413928 1.639121764 hsa-miR-3119_st 0.738891056 1.337859578 0.459193204 1.222256601 hsa-miR-3120_st 5.382424543 6.105824215 6.885072781 6.261522297 hsa-miR-3121_st 5.865046105 7.246201672 7.681663936 7.657149204 hsa-miR-3122_st 11.0863169 11.05485269 11.10914063 12.55042481 hsa-miR-3123_st 0.735367678 0.835267971 1.745365347 0.673378873 hsa-miR-3124_st 11.68283721 1.136797365 12.52820842 12.48815411 hsa-miR-548s_st 1.442633509 1.472518154 1.172116719 1.26473859 hsa-miR-3125_st 6.504162127 7.182266558 7.520218037 7.417503971 hsa-miR-3126-5p_st 10.96810365 11.62186652 12.68781638 13.00605153 hsa-miR-3126-3p_st 3.953319103 3.978451587 5.048331457 5.129238795 hsa-miR-3127_st 8.884563625 9.039912725 9.64981247 9.9412665534 hsa-miR-3128_st 2.854019924 2.623850359 3.476188214 2.377058234 hsa-miR-3129_st 3.377202117 3.953676414 3.337570019 3.298642869 hsa-miR-3130-5p_st 6.104011466 6.703341513 7.899651325 7.250658705 hsa-miR-3130-3p_st 7.781764224 7.520785865 8.373633709 8.032454092 hsa-miR-3131_st 11.95047502 11.54631808 12.47524853 12.675821367 hsa-miR-3132_st 8.461240608 8.736381457 9.440632407 9.926082683 hsa-miR-3133_st 2.378042587 2.295880487 2.882253985 2.433449311 hsa-miR-378b_st 8.699729699 8.528200972 9.474499779 9.107606241 hsa-miR-3134_st 1.620075696 1.279377813 0.444280401 1.693810819 hsa-miR-3135_st 6.2135514745 6.446723785 6.288928729 6.294295833 hsa-miR-466_st 5.583333986 5.641216216 5.925404787 4.497290916 hsa-miR-3136_st 5.709042043 5.853991317 6.790102542 7.003281584 hsa-miR-544b_st 2.556910659 2.429889652 2.973163073 2.011956337 hsa-miR-3137_st 10.58265506 10.80228301 11.04354704 11.66753526 hsa-miR-3138_st 10.20602609 10.11848337 11.40768658 11.89898801 hsa-miR-3139_st 1.896074286 2.852669535 3.669149066 1.918817763 hsa-miR-3140_st 4.222628987 4.471333241 4.561171795 5.121162607 hsa-miR-548t_st 2.525714261 2.317318822 1.852011068 1.331908769 hsa-miR-3141_st 15.71898682 14.80622412 15.09937963 15.74324263 hsa-miR-3142_st 1.205131996 0.701501475 1.508902008 2.015208406 hsa-miR-3143_st 0.555087091 0.589265729 −0.314516863 0.1.80454299 hsa-miR-548u_st 0.997890624 1.161559813 1.575939429 0.851874369 hsa-miR-3144-5p_st 3.926118612 4.520530436 5.82417076 4.984584952 hsa-miR-3144-3p_st 2.282236025 2.790490565 2.372629955 3.021075861 hsa-miR-3145_st −0.111673215 0.353988674 0.763924371 −0.286856322 hsa-miR-1273c_st 9.882253246 9.964363674 10.69050718 10.54306794 hsa-miR-3146_st 2.945613978 3.625310743 3.479988314 3.574430026 hsa-miR-3147_st 11.31223075 11.06988344 11.26902777 11.74209153 hsa-miR-548v_st 2.920060947 2.993303609 2.05241956 2.208413496 hsa-miR-3148_st 4.167148141 5.000873101 5.431043849 4.917964986 hsa-miR-3149_st 2.754983043 2.867249042 2.011214842 2.10613195 hsa-miR-3150_st 9.615649728 9.11211859 9.746588367 9.932034858 hsa-miR-3151_st 11.44924489 11.11472788 11.80353343 11.82346138 hsa-miR-3152_st 6.541702375 4.690797349 2.984411612 7.814784315 hsa-miR-3153_st 9.354932089 9.202213372 9.87868729 10.01096999 hsa-miR-3074_st 4.501612427 4.491314484 4.753265571 3.719386519 hsa-miR-3154_st 11.49774802 11.12714529 11.72343524 11.99313811 hsa-miR-3155_st 6.565851986 6.889214589 7.542009555 7.662245725 hsa-miR-3156_st 9.928795173 9.903434578 10.05090179 9.892850521 hsa-miR-3157_st 5.305026019 5.074194853 6.611393865 5.805131658 hsa-miR-3158_st 3.955107788 4.291612812 5.901754412 4.579903461 hsa-miR-3159_st 4.035939071 4.32783237 5.414366599 3.342490764 hsa-miR-3160_st 5.280229075 5.375606752 4.249289009 4.859477079 hsa-miR-3161_st 6.017152498 6.591561574 7.038460631 7.443594734 hsa-miR-3162_st 13.78868534 13.3045883 13.82420336 14.13551663 hsa-miR-3163_st 7.335080458 7.788269015 8.516681454 8.219031745 hsa-miR-3164_st 5.482057365 6.455302725 6.73749629 7.063559483 hsa-miR-3165_st 6.348356354 6.919507228 8.384407521 8.460337368 hsa-miR-3166_st 4.255315724 3.566827129 4.193637407 4.062160516 hsa-miR-1260b_st 14.13645693 13.31450831 13.27181796 14.15228502 hsa-miR-3167_st 1.359122744 1.259165833 2.177125463 1.568751667 hsa-milt-3168_st 2.122248955 2.176182938 2.567775628 2.471731792 hsa-miR-3169_st 3.90841288 3.555686667 3.133065499 3.575791301 hsa-miR-3170_st 6.004392899 5.864261805 6.880459689 6.613095322 hsa-miR-3171_st 2.667171702 2.387096828 1.198033798 2.248682366 hsa-miR-3172_st 35.92077025 14.68880989 15.11734161 15.14609441 hsa-miR-3173_st 9.048177133 8.968976691 9.411201517 9.520804629 hsa-miR-1193_st 9.911480551 9.636563813 10.09103872 10.42165416 hsa-miR-323b-5p_st 6.945202112 7.524213663 8.223721373 7.548105125 hsa-miR-323b-3p_st 2.419752805 2.294720423 2.165882863 2.014582413 hsa-miR-3174_st 5.377129063 6.508082051 7.645911237 6.573067633 hsa-miR-3175_st 12.93931604 12.66498524 13.32768879 13.59467072 hsa-miR-3176_st 10.72480996 10.37095989 10.89275954 10.66606667 hsa-miR-3177_st 11.36567443 11.28019025 12.03209576 12.3665468 hsa-miR-3178_st 16.21059466 15.19604729 15.3340853 16.14169734 hsa-miR-3179_st 2.887270068 3.337387994 3.816917295 4.193563805 hsa-miR-3180-5p_st 7.635121632 7.430306941 8.44798072 8.310428335 hsa-miR-3180-3p_st 15.1994894 14.37446565 14.90086765 15.42058031 hsa-miR-548w_st 6.673203927 6.550087426 4.029213156 4.404701612 hsa-miR-3181_st 8.467396794 8.054873157 9.078799228 8.846671007 hsa-miR-3182_st 3.16117371 3.220767719 2.395839408 2.521380618 hsa-miR-3183_st 3.297133256 3.742008798 4.994021886 5.047533899 hsa-miR-3194_st 9.463583975 9.242817485 10.1691606 10.22021817 hsa-miR-3185_st 13.6640327 14.75812583 15.16272631 15.86427235 hsa-miR-3065-5p_st 3.451786816 3.147668435 1.69895205 2.551370871 hsa-miR-3065-3p_st 3.019294463 4.097916906 4.821272566 4.186438595 hsa-miR-3186-5p_st 3.620689213 4.401528046 4.470002531 3.498190896 hsa-miR-3186-3p_st 8.496605877 8.552527963 9.640403704 8.863884674 hsa-miR-3187_st 12.59381048 12.34988788 13.34906934 13.52923318 hsa-miR-3188_st 12.96506681 12.6688561 13.5748588 13.8780603 hsa-miR-3189_st 7.249371513 7.344889529 8.312516751 7.957371797 hsa-miR-320c_st 10.48111268 9.327977586 8.212206741 8.319047394 hsa-miR-3190-5p_st 9.652359814 9.807611909 10.21870217 10.61183419 hsa-miR-3190-3p_st 9.892239451 9.9510742 19.64439145 10.77693315 hsa-miR-3191_st 11.0830004 11.19477116 11.86977093 12.48403807 hsa-miR-3192_st 8.470003126 8.637509546 9.490772075 8.981398358 hsa-miR-3193_st 5.769719923 6.007491391 6.666289427 6.283734856 hsa-miR-3194_st 10.01116325 10.33787585 11.08111668 11.64941776 hsa-miR-3193_st 12.65371718 12.62349079 13.04519708 13.80441822 hsa-miR-3196_st 16.8253773 15.68293987 15.33594888 16.35720843 hsa-miR-548x_st 0.1248527 0.312276603 1.236305876 0.548993064 hsa-miR-3197_st 15.25351605 14.76280554 15.11766207 15.88380859 hsa-miR-3198_st 9.516123713 9.56709137 10.37375244 10.46456015 hsa-miR-3199_st 4.306521728 4.45176047 6.043481966 5.592119239 hsa-miR-3200_st 3.070729684 3.441688654 2.531463452 2.96866272 hsa-miR-3201_st 3.76016476 3.987363786 4.096188264 4.153246398 hsa-miR-514b-5p_st 9.663950632 9.962281065 10.49206243 10.36380426 hsa-miR-415b-3p_st 1.073350543 1.487872809 1.130047673 1.655528889 hsa-miR-3202_st 7.812265519 7.542395552 8.417045091 −8.354353044 hsa-miR-1273d_st 11.77028387 11.6709639 10.59217381 11.00159289 hsa-miR-4295_st 2.113017483 1.650716633 2.719843815 1.455272015 hsa-miR-4296_st 7.098732239 7.175574426 7.64324757 7.614420881 hsa-miR-4297_st 4.595170908 5.554352442 6.149366799 6.142865613 hsa-miR-378c_st 8.53033554 8.217178808 8.710138926 8.827477528 hsa-miR-4293_st 3.990289864 4.089600536 5.156839509 4.729844589 hsa-miR-4294_st 7.382348631 7.481199535 8.499596592 8.55304756 hsa-miR-4301_st 2.344239551 2.017064066 1.655613837 2.131812365 hsa-miR-4299_st 12.11777373 12.73119768 13.32859055 13.27151577 hsa-miR-4298_st 13.08995053 12.77697854 13.31206505 13.59236967 hsa-miR-4300_st 7.268698715 7.456844024 8.803179915 8.552925365 hsa-miR-4304_st 5.787527746 5.870801767 6.139488076 6.495595167 hsa-miR-4302_st 4.945013657 5.014106472 6.310027957 5.637091239 hsa-miR-4303_st 5.143181804 5.971380004 6.908483815 6.373314087 hsa-miR-4305_st 3.286512482 3.690368588 5.070309387 3.030223299 hsa-miR-4306_st 9.216708673 9.639101996 9.50259055 9.658865651 hsa-miR-4309_st 3.726743084 3.074433833 2.914805719 3.865614409 hsa-miR-4307_st 1.828997925 3.050393996 1.540194065 1.61005368 hsa-miR-4308_st 1.557421473 1.66087641 1.665246583 −0.098516564 hsa-miR-4310_st 2.808520703 2.819603543 4.635336896 2.949926376 hsa-miR-4311_st 4.650444661 5.128340853 5.377693933 4.349796503 hsa-miR-4312_st 6.127439891 6.607877135 7.883909102 6.69264288 hsa-miR-4313_st 5.562308902 5.707320771 6.723536981 5.423431952 hsa-miR-4315_st 2.243168815 2.653119732 2.987270516 2.620692902 hsa-miR-4316_st 7.483488844 7.26321408 8.080742863 8.393380861 hsa-miR-4314_st 8.40250987 8.17214178 9.604787925 9.303692084 hsa-miR-4318_st 2.654578226 3.623085724 3.084754315 2.280820913 hsa-miR-4319_st 3.102730444 3.371998623 3.791579557 3.694410614 hsa-miR-4320_st 2.880254648 2.82420049 3.402652417 2.017410231 hsa-miR-4317_st 8.33557065 8.837623024 10.0554715 9.656000175 hsa-miR-4322_st 12.715955512 12.20471674 13.17334529 13.34673293 hsa-miR-4321_st 9.955181327 9.908439559 10.65127282 10.84096092 hsa-miR-4323_st 5.147613483 5.822933319 5.964358581 6.023675447 hsa-miR-4324_st 7.468077064 7.371011277 4.226813577 6.338509284 hsa-miR-4256_st 3.840062511 3.92147895 3.992051935 3.833036528 hsa-miR-4257_st 11.85072847 12.07146525 12.95533475 13.20619486 hsa-miR-4258_st 7.835951648 7.521094447 7.774478173 8.196121982 hsa-miR-4259_st 11.22028681 10.89034974 11.28400256 11.89975642 hsa-miR-4260_st 10.22753334 10.3305395 11.33693614 11.48469591 hsa-miR-4253_st 11.27381284 10.94377554 11.78299111 12.01375435 hsa-miR-4251_st 5.247752931 5.834816805 6.319884071 6.535681026 hsa-miR-4254_st 5.575751709 5.512302837 5.309655955 4.667917989 hsa-miR-4255_st 3.113345185 2.381933512 1.366451826 7.557792937 hsa-miR-4252_st 4.642329613 4.601515033 4.905025678 4.684139082 hsa-miR-4325_st 3.2248685 2.812017108 3.168209875 2.256222273 hsa-miR-4326_st 4.969969258 4.172804398 6.257555083 5.277796448 hsa-miR-4327_st 12.2435562 11.91994721 12.43537573 12.55450382 hsa-miR-4261_st 8.061055429 8.581054432 8.833331508 8.488958353 hsa-miR-4265_st 6.867547783 7.464642575 7.971004655 8.097834643 hsa-miR-4266_st 5.978349239 6.120270507 6.524133334 6.919127356 hsa-miR-4267_st 5.089888506 5.721675396 5.671919771 6.112771819 hsa-miR-4262_st 1.068759287 1.645914408 2.98917695 1.422560709 hsa-miR-2355_st 1.770925776 1.983582634 2.015509587 2.910491525 hsa-miR-4268_st 3.715547239 3.541068169 5.509252136 3.925135426 hsa-miR-4269_st 7.787224879 7.416545045 7.973918336 8.119422079 hsa-miR-4263_st 2.142752819 2.486840227 2.278193495 1.306221794 hsa-miR-4264_st 2.068394171 1.980206287 2.207760671 2.626465906 hsa-miR-4270_st 15.86093217 15.0138598 15.15773455 15.88409745 hsa-miR-4271_st 11.64984361 11.37047897 12.05306749 12.4654521 hsa-miR-4272_st 1.71058204 0.790256489 1.16267958 1.535365445 hsa-miR-4273_st 1.207960197 1.453436788 0.406491662 0.070274307 hsa-miR-4276_st 1.244872957 0.905032176 0.753387042 0.631445531 hsa-miR-4275_st 1.743568249 1.941266577 2.485463958 0.979681498 hsa-miR-4274_st 6.019798539 5.355152175 4.971018592 5.803213885 hsa-miR-4281_st 16.43866443 15.3682291 15.33657972 16.23080115 hsa-miR-4277_st 2.397083326 2.716033187 2.586332016 1.94229493 hsa-miR-4279_st 5.357090115 5.662692271 6.536614389 5.766521327 hsa-miR-4278_st 6.270251624 6.807727643 7.677343221 8.285024817 hsa-miR-4280_st 4.016164407 4.402783235 3.886184729 4.003929803 hsa-miR-4282_st −0.03850547 −0.041624091 0.454318683 0.156785332 hsa-miR-4285_st 11.85139308 11.34823563 12.6224675 13.04732808 hsa-miR-4283_st 8.636403456 8.544465088 9.289331874 9.443886953 hsa-miR-4234_st 14.82958188 14.57174313 15.33414685 15.01590166 hsa-miR-4286_st 13.40774722 13.92185021 13.50431208 14.35078797 hsa-miR-4287_st 4.69985764 4.678911609 5.40942507 5.086449512 hsa-miR-4288_st 4.028529409 3.984581289 3.54474729 3.082570632 hsa-miR-4292_st 7.214290498 6.944202264 7.544399934 7.490346603 hsa-miR-4289_st 4.905355479 6.179714771 6.959824746 5.190720705 hsa-miR-4290_st 5.899223832 7.215696878 6.951214183 6.947467062 hsa-miR-4291_st 4.843792255 6.080465464 5.937078493 5.725932852 hsa-miR-4329_st 6.357568907 5.882436315 4.44305889 5.193260045 hsa-miR-4330_st 4.621260415 5.870757673 6.668679549 6.409822521 hsa-miR-500b_st 3.626476586 3.978498443 5.124247944 3.703260432 hsa-miR-4328_st 2.920160349 3.329034389 3.251905407 0.818476267

TABLE 4B normalized array data for the 55 benign and malignant FFPE samples. Average Expression HASH PTC FVPTC FTC OFTC ATC MED miRNA (Mean) (Mean) (Mean) (Mean) (Mean) (Mean) (Mean) hsa-let-7a_st 14.15558717 14.59021467 14.79633591 15.05698319 12.67273374 13.66442503 14.22234562 hsa-let-7a-star_st 2.000910793 2.272276021 2.12122997 2.048872311 1.767978037 1.558502008 2.059719333 hsa-let-7a-2-star_st 5.168356321 4.61680414 5.286619394 4.872932612 5.293124276 4.549405249 4.518435998 hsa-let-7b_st 13.27317996 13.58463025 14.28040197 14.08870415 11.74870694 12.66805825 13.59467828 hsa-let-7b-star_st 6.817059455 6.069718412 6.30137353 5.666949977 6.373685054 6.99973529 6.382344652 hsa-let-7c_st 13.84045117 14.25013036 14.72490417 14.77839155 12.06631017 13.17694019 14.03440391 hsa-let-7c-star_st 3.152252428 3.83595483 3.915512562 4.160489257 4.442004088 4.448860523 4.159266112 hsa-let-7d_st 13.49512033 14.07276021 14.56294519 14.71702284 12.37431602 13.16709374 13.78320506 hsa-let-7d-star_st 7.719150742 7.842045647 7.10659991 8.149559654 7.442085512 7.293443086 7.660955046 hsa-let-7e_st 11.63534653 12.77464894 13.22930831 13.43136103 11.00485748 11.27898959 12.59794682 hsa-let-7e-star_st 4.395542061 4.237150173 4.191062972 4.00496397 4.85917825 3.777219302 3.989818735 hsa-let-7f_st 13.86770986 14.17270133 14.10332693 15.03109521 12.48534444 13.1700209 13.7628527 hsa-let-7f-1-star_st 4.748353076 3.240654007 4.196818355 3.220476391 5.39538426 4.544562842 4.040318715 hsa-let-7f-2-star_st 2.642786315 2.24369218 2.66054664 1.403793951 2.187887944 2.453876072 1.765776531 hsa-miR-15a_st 10.22855261 10.78554572 11.78138922 11.61137172 9.208379685 9.55795377 10.03911845 hsa-miR-15a-star_st 4.537517946 4.23094415 3.790423445 4.078921743 5.221031665 3.371420821 4.389824211 hsa-miR-16_st 13.67601185 13.91398442 14.45033516 14.30677628 11.56732264 13.41227708 13.35525998 hsa-miR-16-1-star_st 3.567191861 3.49373081 3.934272778 3.874926103 3.149129864 4.565050367 3.279612644 hsa-miR-17_st 10.33571266 10.35543015 11.70579728 11.17207422 9.350341962 9.497373109 8.976596477 hsa-miR-17-star_st 5.533789427 5.802410675 6.615134745 6.244423759 6.168633685 5.627433445 3.308338717 hsa-miR-18a_st 5.002356167 4.78929286 5.820447886 5.5881992 5.623384578 4.647298608 4.119516835 hsa-miR-18a-star_st 4.745056518 4.881361159 4.71148011 4.768974009 5.363608716 5.512723702 4.103737228 hsa-miR-19a-star_st 0.898433319 0.978313376 0.337970327 0.16307698 0.63379919 0.105735692 0.412517604 hsa-miR-19a_st 5.545129704 4.92264926 6.730049896 6.990245501 4.719046431 3.523181402 1.85946981 hsa-miR-19b-1-star_st 2.075057342 2.915718065 3.862448035 2.471369829 2.870994001 1.613601082 1.049024525 hsa-miR-19b_st 10.15135781 9.874982906 10.69568346 11.23338678 9.37194437 8.973546187 7.655901885 hsa-miR-19b-2-star_st 1.267334379 1.345956033 1.998329834 −0.141021071 1.530205954 0.489036019 0.602051649 hsa-miR-20a_st 9.842580341 9.209579827 11.18583966 10.70485318 9.310415945 8.800586904 8.429350381 hsa-miR-20a-star_st 4.44557718 7.677528358 4.30644141 5.227305497 6.9900236 2.48889582 6.566144449 hsa-miR-21_st 11.54698196 13.04009013 11.98964111 13.11796716 11.10399051 13.87368972 12.05333621 hsa-miR-21-star_st 6.30420299 6.778416463 6.316638798 6.5515016 6.631277332 7.976329149 5.735722094 hsa-miR-22-star_st 6.421952845 6.789741956 8.524052209 9.106625368 8.151159519 6.617810833 7.31101491 hsa-miR-22_st 11.05277738 11.44987129 13.27065348 13.13256133 11.24763135 11.9823142 11.28321014 hsa-miR-23a-star_st 10.31104907 9.858473752 9.903093535 10.01753639 10.73847369 10.93500291 10.65124107 hsa-miR-23a_st 13.5963321 14.53458654 14.78480566 14.8950786 12.43065282 14.20246249 14.76056881 hsa-miR-24-1-star_st 2.890137011 3.273428365 5.168339476 5.737672979 3.566322415 2.189673162 5.165794755 hsa-miR-24_st 12.74765201 13.68250263 14.28444905 14.21881702 11.7794624 13.14715514 13.75024265 hsa-miR-24-2-star_st 4.932204015 5.746042115 6.81998025 7.530642489 4.675881831 6.852119208 5.301711427 hsa-miR-25-star_st 12.1346603 11.04052605 11.43680338 11.14512285 12.04988373 12.89759501 12.34140131 hsa-miR-25_st 10.39185859 10.10631951 11.36722724 11.67144628 9.181655345 10.43144687 10.25257266 hsa-miR-26a_st 14.77205274 14.9925562 14.29109135 15.36110683 12.82152635 14.22653157 14.35755585 hsa-miR-26a-1-star_st 1.426595703 1.395898206 1.375607255 1.583961486 2.158652188 1.15896614 1.574951234 hsa-miR-26b_st 11.45304815 11.73506896 11.71530952 13.57376249 10.27168874 10.19870097 11.87214728 hsa-miR-26b-star_st 4.799189993 4.863637795 5.860061359 6.363199271 4.169823611 4.235954019 5.119257805 hsa-miR-27a-star_st 5.170785201 5.480304052 4.926467582 5.935919287 5.764092638 5.474807064 4.366513168 hsa-miR-27a_st 11.83395926 12.70262712 12.91788995 13.56781561 10.81134798 12.05985028 12.54097106 hsa-miR-28-5p_st 7.926705601 8.039287499 9.87504255 9.903931374 6.804963959 8.362124195 8.654979082 hsa-miR-28-3p_st 6.47522152 6.384773469 6.772715323 7.239416061 5.003913242 7.516807855 6.898328183 hsa-miR-29a-star_st 1.236542813 2.427204244 1.993710542 1.138996668 2.941554319 1.406089468 0.339519955 hsa-miR-29a_st 13.1147982 13.78672265 13.91974692 14.64068283 12.44553549 12.94341798 13.38369759 hsa-miR-30a_st 11.82133057 12.09619493 13.49493147 13.81781814 11.01569113 10.35405371 11.7092504 hsa-miR-30a-star_st 9.397240205 8.690107102 10.71191557 11.3324932 8.806171869 6.644641364 7.522593943 hsa-miR-31_st 9.93589464 11.66755968 10.0728959 10.77522615 6.617768559 11.07542167 6.899861768 hsa-miR-31-star_st 4.482548351 5.822449532 4.962247496 5.929216999 1.021173127 4.838256477 2.0223309 hsa-miR-32_st 0.353603165 2.062220233 0.768164548 2.194132191 1.041383646 1.155493738 0.341168283 hsa-miR-32-star_st 2.99947611 3.151384348 3.834688154 3.406030872 1.409075005 1.329716854 2.431588363 hsa-miR-33a_st −0.711921589 0.893086155 1.185216905 1.104654008 0.721154112 0.2920118 −0.42424147 hsa-miR-33a-star_st 3.124682244 2.767795205 3.930904133 5.591248043 2.837470909 1.893753394 2.109337512 hsa-miR-92a-1-star_st 7.203125347 6.804136576 7.289368022 7.986137877 7.243504228 8.061767379 8.293312403 hsa-miR-92a_st 10.36678173 11.22137732 11.45815148 11.23863627 9.378182258 10.26781596 9.958756909 hsa-miR-92a-2-star_st 8.419567696 8.023478386 8.333560558 8.508241911 8.366199316 9.263381064 9.154700975 hsa-miR-93_st 9.381962353 9.51784926 11.57735451 10.82438539 8.515727457 9.637784101 9.288556963 hsa-miR-93-star_st 4.823343886 4.674976822 5.294583512 5.261968088 5.029624933 4.586652533 5.518594839 hsa-miR-95_st 6.605124298 6.582011528 8.159989018 9.566997361 6.047061768 4.577933434 8.147387044 hsa-miR-96_st 4.06747702 5.665218456 7.302927712 7.881283843 5.558531727 3.591208411 6.495520721 hsa-miR-96-star_st 3.23829881 3.183461799 3.757992978 3.665806318 2.742345389 1.921073934 3.036074318 hsa-miR-98_st 8.764035515 9.582128348 11.28216671 11.19300317 9.248880372 8.491389814 9.806015732 hsa-miR-99a_st 12.12833834 12.52868936 13.32185912 13.12940031 10.98598063 11.27890857 12.79287611 hsa-miR-99a-star_st 3.920141689 4.695537102 5.540634899 5.095796428 6.034168337 3.969663981 5.153626375 hsa-miR-100_st 12.06947437 11.95528815 12.93969011 13.02190847 10.9314438 11.9555963 12.39840916 hsa-miR-100-star_st 1.868638372 2.040636571 1.60575921 1.730884757 2.189441974 2.076183724 1.735104117 hsa-miR-101-star_st 2.774201676 2.517878954 3.441190905 2.356353358 2.957629665 1.558055369 1.599150544 hsa-miR-101_st 5.192614949 6.207942029 6.982511176 6.619860027 4.414594501 3.516447501 4.589175546 hsa-miR-29b-1-star_st 6.202272412 5.867594055 7.076130015 6.770624046 6.314643455 5.417821018 5.292955967 hsa-miR-29b_st 11.17914318 12.2967625 11.75861177 13.30816913 10.29315732 10.56349555 11.13933078 hsa-miR-29b-2-star_st 7.031637888 7.226713588 8.740549041 9.610294833 6.801455244 6.200969235 8.267482535 hsa-miR-103-2-star_st 5.214095015 4.949109865 5.356796976 5.41040604 4.933801977 5.241155419 4.919688613 hsa-miR-103_st 11.88316092 12.43837453 13.76870378 13.67006857 11.36550876 11.69697438 12.00691348 hsa-miR-105_st 2.733230098 2.473734812 1.878935221 1.569650397 2.584630708 1.633457684 1.438569598 hsa-miR-105-star_st 2.910784228 2.304464764 2.620903285 3.303375162 3.221779591 2.94482592 2.845816659 hsa-miR-106a_st 10.34722345 10.38103063 11.84159746 11.09438953 9.25435793 9.487342321 8.930793388 hsa-miR-106a-star_st 1.362472709 2.290006472 0.570145726 1.511380533 0.224515551 0.491056474 1.62560452 hsa-miR-107_st 11.69556531 12.36038512 13.57948492 13.53198517 10.7912168 11.59297499 12.07227501 hsa-miR-16-2-star_st 3.973489139 4.087432032 4.530458716 3.788449282 4.9965682 2.320337009 4.520236468 hsa-miR-192_st 7.492753339 7.058302068 8.909646011 9.130219767 6.803319762 5.532400548 6.009148637 hsa-miR-192-star_st 3.418696746 4.151977557 4.023693518 4.83942338 3.103107233 2.796057305 3.101445368 hsa-miR-196a_st 2.222208824 3.378319401 3.57719364 3.288017833 3.398751492 2.490453722 2.870212301 hsa-miR-197_st 7.738885553 7.215557733 6.425273481 7.788989972 7.176391256 7.216398895 6.904313002 hsa-miR-198_st 11.8334179 11.4220187 11.31439721 12.01765106 11.7956482 12.63872181 12.59586918 hsa-miR-199a-5p_st 10.09721053 9.449549306 10.77755948 10.59055768 7.437834534 11.27821785 9.908600555 hsa-miR-199a-3p_st 11.5616895 10.58923267 11.97851807 12.35393875 8.250820644 12.34931903 11.44429994 hsa-miR-208a_st 2.044248201 2.942199916 2.949751166 2.392810973 3.123211201 2.529824133 3.122450383 hsa-miR-129-5p_st 10.75875476 10.2285354 9.989510104 10.86639337 11.0719225 11.81694159 11.53393392 hsa-miR-129-star_st 4.435826896 4.456336479 3.393844283 4.703448924 3.909189517 4.093172285 5.017997908 hsa-miR-148a-star_st 4.630457714 4.545521342 4.398764816 5.424393108 4.405005014 4.609467366 4.350362905 hsa-miR-148a_st 10.16047549 10.50327901 11.47098471 12.31219272 9.659307219 9.746201307 9.639611137 hsa-miR-30c_st 12.9739315 13.20297343 13.61263571 14.56123872 12.03154511 11.56601999 12.90391769 hsa-miR-30c-2-star_st 7.273820491 7.233754822 7.269872796 7.133733724 7.69512299 6.553367089 6.810625105 hsa-miR-30d_st 11.53951636 12.26949304 13.33428583 13.25323129 10.58560508 10.73618037 12.21827765 hsa-miR-30d-star_st 2.659001626 2.266437028 3.558440047 3.560641096 3.253253053 0.656983056 1.415498987 hsa-miR-139-5p_st 6.991887904 6.188167636 7.056761228 6.771251705 4.672489331 5.433336135 4.28007157 hsa-miR-139-3p_st 7.497881274 6.718077082 7.020533496 6.844999487 7.737523062 7.683109716 7.597040698 hsa-miR-147_st 4.286284966 4.231462063 3.596554731 4.051340218 4.449678211 3.523859523 3.60707822 hsa-miR-7_st 6.829008756 4.76153663 8.711389161 7.015778387 5.678030047 3.265153284 10.09715629 hsa-miR-7-1-star_st 6.128291711 5.775823686 6.929382687 6.360395059 5.839142228 5.920844784 7.449272665 hsa-miR-7-2-star_st 5.152212561 5.416573335 7.230029186 6.318720515 6.069846332 4.282075592 5.113401839 hsa-miR-10a_st 7.817762825 7.543722306 9.127189043 8.269499463 6.218609015 8.297859122 10.92463042 hsa-miR-10a-star_st 3.823003487 3.559641377 4.128900891 3.36731792 4.512958902 4.450666032 5.913660357 hsa-miR-10b_st 8.974220983 9.213328465 9.506927579 10.1234253 9.529424914 9.34901616 9.955072789 hsa-miR-10b-star_st 3.06527396 3.99684384 3.395801858 3.709203984 4.634592662 3.730818264 4.327067157 hsa-miR-34 a_st 8.633908516 10.03888339 11.81293507 11.03795179 9.419917206 9.753800163 9.170093443 hsa-miR-34a-star_st 5.014888394 6.53248197 6.390812722 7.473209474 6.567990586 6.34249384 5.782483676 hsa-miR-181a_st 10.96798371 12.653882 13.0799677 14.10751045 9.455426499 11.95980569 11.27802999 hsa-miR-181a-2-star_st 7.330540203 8.784836445 10.23210011 10.63227287 6.481159895 7.338199195 6.465805715 hsa-miR-181b_st 9.767864295 11.35343817 11.85274514 12.80521069 8.714115373 10.70360943 9.938603195 hsa-miR-181c_st 6.827420887 9.144540298 9.513495627 10.4666294 5.910773463 8.254549086 7.645745719 hsa-miR-181c-star_st 6.49754933 6.254712519 7.474375122 6.292237196 6.769313803 7.371440703 6.323862707 hsa-miR-182_st 6.677081403 8.885071506 10.61688438 10.28127884 8.102190578 6.680846331 10.37933166 hsa-miR-182-star_st 2.012069982 1.919635521 1.501307095 0.944835915 1.867009587 1.854240768 1.857618328 hsa-miR-183_st 3.766386098 5.360403714 5.511571562 7.123350479 5.125361201 4.317192692 7.944247235 hsa-miR-183-star_st 6.89440698 6.410652784 6.091296487 6.550299392 6.916808505 7.601743634 7.239483546 hsa-miR-187-star_st 9.526590037 8.775800551 8.581223968 8.884449193 9.637912093 10.13708744 9.730203101 hsa-miR-187_st 4.672892852 4.092445298 4.309999443 4.105007888 5.142451974 4.310364957 2.923682593 hsa-miR-196a-star_st 4.36952091 4.67877903 4.781823853 5.047647902 5.718324409 4.771580955 3.725223479 hsa-miR-199b-5p_st 7.593858521 5.598570435 7.292452208 7.89141558 4.37259123 9.015192133 6.04669207 hsa-miR-199b-3p_st 11.41795063 11.06442715 11.84681756 12.20388891 8.031814669 12.27579123 11.33329201 hsa-miR-203_st 5.245024372 7.151890717 7.504746081 6.2452748 7.477416154 5.851978878 3.458763043 hsa-miR-204_st 5.663648348 5.664581417 7.82831927 7.233124112 5.142731169 1.986843962 5.022496021 hsa-miR-205_st 5.335849885 4.28878994 4.599205678 5.028069709 2.267075636 8.308836448 1.218782129 hsa-miR-205-star_st 5.445961267 4.606051166 5.154179779 4.395409233 5.284450763 4.248301802 5.633643845 hsa-miR-210_st 11.84418496 11.78697555 11.45186249 12.16162053 12.10456496 12.88926558 12.70932084 hsa-miR-211_st 6.339653367 4.628308407 5.085480393 3.795096046 6.5372267 5.081828594 5.143133761 hsa-miR-212_st 5.976116621 6.158293546 6.370343852 5.523670347 6.798856131 6.479408109 6.007727052 hsa-miR-181a-star_st 4.357356256 5.466988472 5.892538151 7.643065661 4.121950974 5.861952622 5.253225189 hsa-miR-214-star_st 5.088593454 4.594336315 5.816660233 5.046719015 4.460684971 6.018471611 6.2945065 hsa-miR-214_st 10.62938533 9.658784309 10.44747637 9.582368563 10.19162672 10.71961042 9.901004022 hsa-miR-215_st 4.270591269 4.311806864 5.098956407 5.485850806 4.801810688 3.617281012 3.941171568 hsa-miR-216a_st 1.883856723 2.286469844 1.42625946 3.822753636 3.952866256 1.73311264 1.757123104 hsa-miR-217_st 1.695666778 3.035235214 2.301735044 2.412148892 3.240006341 2.49636166 2.038495932 hsa-miR-218_st 3.507417369 4.738090632 5.880315143 6.813675371 3.670812429 5.136511661 2.555380674 hsa-miR-218-1-star_st 1.80837225 1.631812146 0.767883102 1.115131244 2.462172456 2.233346376 1.476511475 hsa-miR-218-2-star_st 3.460035795 3.457361177 3.011797663 2.055196392 3.609866248 2.735933066 2.005229681 hsa-miR-219-5p_st 0.558006232 0.726226699 1.215404486 −0.02016011 1.479172476 −0.343115386 0.18328327 hsa-miR-219-1-3p_st 4.381347765 4.477786371 4.425702516 4.951708927 4.707411535 5.034158813 4.379737187 hsa-miR-220a_st 2.087789184 2.425674514 2.357882657 1.538952393 1.676918204 1.647878646 2.501871406 hsa-miR-221-star_st 6.066776382 8.563593398 9.559644886 6.630949794 6.979899544 7.203735635 7.089821709 hsa-miR-221_st 12.13001047 14.57854186 14.26153434 12.53174497 11.64481607 13.89436439 13.27234191 hsa-miR-222-star_st 5.818279578 7.132332433 7.589451472 5.531120456 6.541231848 5.708590479 4.920460405 hsa-miR-222_st 11.98922523 14.51881613 13.96555929 12.41445009 11.58376583 13.59523865 12.86215637 hsa-miR-223-star_st 3.163623433 3.358138524 2.774117573 3.457772071 2.444782519 4.449474443 2.491377585 hsa-miR-223_st 9.650721078 8.603195453 8.375693368 10.66239316 8.552718061 10.80554703 8.168209329 hsa-miR-224_st 5.064450025 6.411892369 7.704669542 8.739896628 6.750249122 7.249377988 6.885702763 hsa-miR-224-star_st 4.507544545 5.064934247 5.929024663 6.906067197 5.280013536 4.859059332 5.030770951 hsa-miR-200b-star_st 6.105280153 6.258765338 5.611969958 6.062586469 5.754332265 5.515944588 6.652708038 hsa-miR-200b_st 10.60880916 11.58154047 10.62678477 12.60697709 7.14146164 9.065166932 11.11433327 hsa-let-7g_st 13.18726298 13.34889669 13.82042491 14.78719799 11.67193933 12.65946324 12.83057161 hsa-let-7g-star_st 4.529559879 4.591773812 5.02643075 4.415556107 5.519437669 5.28765056 4.648485709 hsa-let-7i_st 13.32603748 14.0670837 14.79153195 15.03012353 11.66674839 13.38627063 12.74185859 hsa-let-7i-star_st 5.994641236 6.187109219 6.557306317 5.853826111 5.755943505 6.20908114 5.45977697 hsa-miR-1_st 2.895608646 2.354832255 5.688104289 4.810969245 3.377879698 2.66589044 4.564563909 hsa-miR-15b_st 10.10475455 10.60944185 10.99276936 11.39267049 8.616058957 9.222821702 9.753888403 hsa-miR-15b-star_st 4.141388282 1.82713164 2.592140593 3.264764547 4.037068329 2.504335849 2.981822737 hsa-miR-23b-star_st 5.341773863 5.381732117 5.073605297 5.482529408 4.939352772 4.560027664 5.249563316 hsa-miR-23b_st 13.78050337 14.63961365 14.7121197 15.07621511 12.25217307 13.94532136 15.12780576 hsa-miR-27b-star_st 5.899655559 6.447717923 7.816555897 7.492233784 6.693311721 5.199909202 6.907610254 hsa-miR-27b_st 11.70151257 12.41039491 13.34233946 13.99454949 10.82641477 11.23271974 12.80217355 hsa-miR-30b_st 12.04580773 12.4872028 13.10948587 13.78897012 10.56878692 10.41817895 11.8810397 hsa-miR-30b-star_st 8.76947302 7.781993417 8.118760757 8.094038443 9.319870737 9.002742118 9.07655031 hsa-miR-122_st 3.585326852 2.737253917 3.446951702 3.027338387 4.430544251 2.375744402 3.762012074 hsa-miR-122-star_st 1.964075286 1.947571948 1.142933974 2.207985365 2.351621695 1.979414234 1.923152294 hsa-miR-124-star_st 4.794079348 5.095088673 3.948924275 5.135005308 4.894830939 5.298676745 4.750264324 hsa-miR-124_st 7.806511128 7.784305524 7.07705244 7.397269122 6.743404889 8.627227002 8.925469795 hsa-miR-125b_st 14.1919019 14.97554962 14.42866721 15.29685476 12.40493896 13.731989 14.83731351 hsa-miR-125b-1-star_st 11.36946131 11.16199369 10.49754353 10.83320229 11.62693935 12.26047773 11.90564221 hsa-miR-128_st 7.422848484 7.216004634 9.276139556 9.140042075 6.32007373 7.407939845 8.333243989 hsa-miR-130a-star_st 0.786479804 2.10985463 1.544702029 0.631679791 1.451754806 0.991927412 0.787444139 hsa-miR-130a_st 10.95251849 11.3280284 12.77911769 12.79495895 9.652723919 9.584293959 9.26605896 hsa-miR-132-star_st 1.741616958 2.682784372 4.012137023 3.684869004 3.167044926 3.247791097 4.216315171 hsa-miR-132_st 6.784279235 7.041617861 7.180649067 7.613218152 4.23808657 7.382487951 8.819555589 hsa-miR-133a_st 4.021975192 4.04792149 5.808665815 5.20248349 5.052777918 3.559910657 5.077578674 hsa-miR-135a_st 1.067953188 1.748144202 4.43473341 4.308808333 1.950107949 0.317751258 1.116647141 hsa-miR-135a-star_st 11.83549917 11.33078949 11.11368328 11.85564522 11.92740925 12.59260092 12.38596622 hsa-miR-137_st 2.001380579 1.815176614 1.392432866 1.364279415 0.825130406 1.751735688 0.982315307 hsa-miR-138_st 10.42071623 9.974431864 12.2247727 10.17848543 9.684958709 7.777501433 8.895437529 hsa-miR-138-2-star_st 4.681402799 4.037846732 4.139818818 4.195616795 5.043503354 3.500263107 4.116858746 hsa-miR-140-5p_st 4.280632595 4.484409805 5.938300771 7.505254469 4.415534157 4.585066748 5.856707796 hsa-miR-140-3p_st 11.21159969 10.34538914 11.6177264 11.49546455 9.837357601 10.58542797 10.54373498 hsa-miR-141-star_st 1.764082774 1.60780637 3.762955058 3.166838758 3.970558121 0.927821235 1.071939233 hsa-miR-141_st 8.246432824 9.722639288 10.5589574 10.87221424 8.489656305 6.001322071 6.726696143 hsa-miR-142-5p_st 7.697000272 4.46124026 4.251002986 4.771781888 5.545056055 6.609062526 3.020451748 hsa-miR-142-3p_st 1.479133811 1.627178642 0.558456298 −0.236153373 1.150118252 0.605999308 −0.040190223 hsa-miR-143-star_st 6.798823037 5.997180428 7.582575695 6.680777283 5.598154425 6.176383002 5.883719468 hsa-miR-143_st 12.20141256 11.65121946 13.6549655 13.96978701 9.839501741 11.58629479 12.53737939 hsa-miR-144-star_st 2.289380183 3.064744909 3.077131071 2.995776582 1.409755128 1.813221703 2.269920652 hsa-miR-144_st 1.033913323 1.408971929 0.847876762 0.321653442 0.652074446 −0.056050181 0.524737705 hsa-miR-145_st 12.75665105 12.17800278 13.89739783 14.40965082 10.9061954 12.27661388 13.98583179 hsa-miR-145-star_st 4.692695925 4.569718396 6.199548484 7.17489021 4.405981305 4.699893983 5.774812742 hsa-miR-152_st 9.314848588 9.244788583 11.67251664 11.14921919 8.46429467 8.882691036 8.801029044 hsa-miR-153_st 1.170922889 2.354372267 0.91566264 1.209452907 1.451366337 0.92719961 1.96295281 hsa-miR-191_st 12.42525393 13.19851021 13.62382892 13.32984752 10.85053591 12.23517027 13.0339579 hsa-miR-191-star_st 6.577628988 5.530830507 5.213814831 5.707216115 7.181439317 6.27655688 6.54464126 hsa-miR-9_st −0.8869132 0.224301916 0.388235346 −0.985842924 0.137574801 −0.430840486 2.48388758 hsa-miR-9-star_st 2.194109126 2.205316629 1.552981658 3.599083918 0.933166235 0.857813509 3.304189879 hsa-miR-125a-5p_st 12.59010926 13.88134014 13.45615422 14.10534867 11.44457428 12.21721845 13.40101043 hsa-miR-125a-3p_st 11.82467831 11.17649043 11.27485903 11.30233652 11.81059014 12.06138848 12.01479309 hsa-miR-125b-2-star_st 9.598723423 8.351435282 8.778905155 9.224655821 9.533268049 10.07319994 9.226995842 hsa-miR-126-star_st 0.480778016 0.984734729 2.074256246 0.919074692 1.953659055 0.55697652 0.564760027 hsa-miR-126_st 13.40627171 12.99389586 14.2865301 14.7325165 11.73948371 12.51033892 12.09179883 hsa-miR-127-5p_st 6.065131497 5.435765839 6.376483893 5.215929537 7.21081578 6.832409463 6.671427078 hsa-miR-127-3p_st 5.688982631 5.569513571 5.57320905 5.22420258 6.642025421 7.720184782 9.678530601 hsa-miR-129-3p_st 3.147432386 3.774912408 3.134068451 2.363771153 3.775266892 2.476258704 5.931930163 hsa-miR-134_st 7.357268722 7.380168804 7.355223284 8.278940631 8.015559424 9.287592102 8.619861335 hsa-miR-136_st 1.681412199 0.839714928 1.475878647 1.86121057 −0.291764768 0.180251077 0.020485652 hsa-miR-136-star_st 1.664595123 2.259961149 1.79879255 1.685114936 0.685413677 1.306515497 0.826916125 hsa-miR-138-1-star_st 7.369352767 6.021438987 7.988706123 7.335679479 6.471158139 6.381567728 6.703012699 hsa-miR-146a_st 10.93507161 9.636324716 10.36910697 10.37269315 8.261485267 10.12460409 7.016099341 hsa-miR-146a-star_st −0.026692432 1.645291388 1.709677264 1.908031509 0.385516821 1.129266889 1.235996692 hsa-miR-149_st 6.415664237 6.662821575 6.635770335 6.956451277 6.599391906 6.815466089 7.641749729 hsa-miR-149-star_st 15.08862573 15.7012122 15.01057966 15.43442102 14.53262325 15.83176583 15.66375449 hsa-miR-150_st 13.1287096 9.670581011 9.044907059 10.43796227 8.600444415 11.39620093 8.450111524 hsa-miR-150-star_st 12.78897006 12.31848817 12.11511701 12.6453347 12.59304601 13.86507565 13.29326258 hsa-miR-154_st 4.617459155 3.528313533 3.324393825 3.020937689 4.658377149 4.141740026 5.125460616 hsa-miR-154-star_st 3.669627148 2.91163797 3.013163581 2.071177464 3.32964704 3.167627229 3.339111144 hsa-miR-184_st 6.936745513 6.622640674 6.645739239 6.646598493 8.497840203 7.517968989 7.294637147 hsa-miR-185_st 9.400888787 8.881011032 10.5448793 10.12657698 9.606802476 8.698018295 8.147289208 hsa-miR-185-star_st 9.434281223 7.848030887 8.55341008 9.045785034 9.630778121 9.602970198 9.696949212 hsa-miR-186_st 4.395239757 3.454877209 5.679008137 5.783911032 3.69175877 4.023561427 3.841284529 hsa-miR-186-star_st 0.090880609 0.585351444 1.042973241 2.179470582 0.363104408 0.637384472 0.872261176 hsa-miR-188-5p_st 6.186688709 6.503704553 6.573393633 6.547511844 7.198634804 7.688234431 7.34307882 hsa-miR-188-3p_st 3.482262449 3.158909902 3.858285782 3.303776724 4.220118015 4.047598422 3.603964985 hsa-miR-190_st 0.032419558 0.1137425 −1.217677031 −0.768260639 −0.396461744 0.084487406 −0.002141882 hsa-miR-193a-5p_st 12.00175793 11.5281307 10.8349368 11.3279787 11.52244986 12.57322299 12.31279765 hsa-miR-193a-3p_st 7.436717114 7.166387083 8.0179642 6.073969598 6.290215771 7.20796229 5.10580256 hsa-miR-194_st 7.167387408 7.251847965 8.744947191 8.547775573 5.909894737 5.657501474 5.562160525 hsa-miR-195_st 11.01947046 10.70380498 12.00806291 11.9823632 10.38711643 10.17200071 10.95026168 hsa-miR-195-star_st 5.312914015 4.874648244 4.704450833 5.83733951 5.37893907 5.918313564 4.750944732 hsa-miR-206_st 5.326304161 5.637537948 5.367506599 5.238271939 6.00097516 4.771024315 5.694402695 hsa-miR-320a_st 12.07583982 12.03895857 12.25696961 11.82901769 11.43862693 12.06035041 12.00940815 hsa-miR-200c-star_st 3.425551521 3.183613734 4.193372991 2.42074175 3.310670347 2.9424622 3.578695497 hsa-miR-200c_st 12.53647947 13.65745284 14.40176071 14.20922481 11.73747464 10.76346356 12.46358892 hsa-miR-155_st 11.25575445 9.035329102 8.985833032 9.192711002 8.680173678 10.73279074 7.105913695 hsa-miR-155-star_st 1.964949002 2.467721388 2.054812113 2.08884536 2.023930208 1.732035151 1.557014646 hsa-miR-194-star_st 7.69841929 7.733534988 7.240230495 7.181817602 8.332122903 8.687291268 8.002536882 hsa-miR-106b_st 9.133106521 9.379692755 11.13695291 10.59803448 8.280212695 8.544609295 8.777741762 hsa-miR-106b-star_st 7.695518233 7.518951706 7.913585085 7.558228849 6.264628013 7.78163287 7.543962549 hsa-miR-29c-star_st 7.88826684 6.769481202 8.042632105 9.761083082 6.934005057 5.186342908 8.823057821 hsa-miR-29c_st 11.03910328 11.59741823 11.54383747 13.44223212 10.21301967 9.626839584 11.08211055 hsa-miR-30c-1-star_st 10.12401426 9.636250605 10.55657357 10.29245385 10.85556273 10.94996051 11.18884027 hsa-miR-200a-star_st 5.923948898 5.84225088 5.6910311 6.306674155 5.818509223 6.595250191 5.966171141 hsa-miR-200a_st 9.697820348 10.05673761 9.748730655 11.90218462 7.520292358 7.599506565 9.883965305 hsa-miR-302a-star_st 3.051030388 2.231881494 2.126364102 2.658996485 3.099562106 2.729499945 1.98996486 hsa-miR-302a_st 1.818872667 2.461408658 2.249238648 2.421394794 3.117085479 1.15466028 0.760130488 hsa-miR-219-2-3p_st 6.899954429 6.438641496 6.790768836 6.670673502 7.616638071 7.105163476 6.500456716 hsa-miR-34b-star_st 3.771201434 5.105646879 6.703511355 6.63403825 3.97003028 3.777145167 4.86408088 hsa-miR-34b_st 6.775058195 5.908339554 6.267935353 4.886271339 7.450826459 6.135950456 4.934693032 hsa-miR-34c-5p_st 2.569358485 2.482194489 3.05156833 2.185736736 3.157294511 2.934435035 2.250833696 hsa-miR-34c-3p_st 6.223597126 5.3698315 5.649786395 5.780885713 6.303876534 6.835290271 6.334604844 hsa-miR-299-5p_st 4.950422237 4.678760546 4.522162223 4.602791037 5.5426922 6.30402748 6.446749465 hsa-miR-299-3p_st 6.173380829 6.162643491 6.835452736 8.074913195 7.040893178 7.389118274 6.849599568 hsa-miR-301a_st 2.748480666 4.239985163 6.177645414 5.237205457 4.406466449 2.825312441 4.463063692 hsa-miR-99b_st 10.13820818 11.16140547 11.79850838 11.94543609 10.11384671 10.3383226 11.30991958 hsa-miR-99b-star_st 8.105670646 7.597073764 7.785265162 8.03851155 7.910051702 8.083388458 7.129505076 hsa-miR-296-5p_st 4.372488258 4.191816415 3.952109545 3.280387923 4.989515121 4.655409834 3.770778919 hsa-miR-296-3p_st 11.51907546 11.23077833 10.92230689 11.32972499 11.32792531 11.98606173 11.68241726 hsa-miR-130b-star_st 4.191301883 3.895084828 4.28694144 4.395341261 4.540856081 4.089406352 3.040887664 hsa-miR-130b_st 7.956017022 7.650604762 9.389567266 8.502937452 6.972951972 7.929065823 7.565687386 hsa-miR-30

_st 9.232191902 9.303211263 10.70646239 11.44577569 9.27682026 8.240636673 8.655339995 hsa-miR-30

-star_st 8.494628404 8.371277672 9.551668823 10.64897779 8.737289833 6.198045921 7.936274296 hsa-miR-26a-2-star_st 0.244237035 0.764557411 1.044437823 3.495767246 0.327660441 −0.228618088 1.072277438 hsa-miR-361-5p_st 10.58812464 10.85021483 11.73611213 11.4796971 9.765335862 10.1677554 10.36498951 hsa-miR-361-3p_st 5.747118185 4.881073277 6.285243737 7.235577328 5.750719479 5.880051395 4.964220924 hsa-miR-362-5p_st 6.593791258 6.42866353 7.579314487 7.254003573 6.302470499 7.014645838 5.810450013 hsa-miR-362-3p_st 2.712235861 3.310294674 4.371779538 5.974499216 3.433370912 2.632662563 1.961924908 hsa-miR-363-star_st 10.47213715 9.763029519 9.306418504 9.455709928 9.924571943 9.856413018 10.31402515 hsa-miR-363_st 5.728431766 4.511752982 7.149971078 6.294731199 5.215647861 4.012664934 4.300000954 hsa-miR-365_st 3.522290291 2.669814289 3.750861188 3.89427793 2.580516873 1.507411815 2.40054963 hsa-miR-365-star_st 10.75938149 10.38724188 10.22970146 10.55777404 10.71054415 11.5138193 11.36758467 hsa-miR-302b-star_st 3.436658334 4.038382435 3.205584347 3.619448918 2.701445033 2.998349206 3.358653139 hsa-miR-302b_st −0.423071411 1.297733625 0.450001229 1.12165908 0.194614368 −0.836145201 0.340801348 hsa-miR-302c-star_st 7.119359015 7.239686523 7.160367409 6.67915066 7.244134197 7.917265947 7.476687232 hsa-miR-302c_st 1.375021698 1.939934228 1.913785856 3.12364524 1.780628403 0.377522923 1.612148806 hsa-miR-302d-star_st 6.786884487 6.467950757 6.232364399 5.834539825 7.741466955 6.229415235 6.171797895 hsa-miR-302d_st 0.931091422 1.465251896 1.617855999 0.818258323 1.893609301 0.148932348 0.949523386 hsa-miR-367-star_st 1.267906574 1.410447263 0.317229568 −0.252566081 1.16283862 1.053480827 0.718642506 hsa-miR-367_st 1.286000411 1.814754325 1.490102954 1.826484384 0.116571705 0.803147056 1.489776233 hsa-miR-376c_st 2.850707327 3.852250516 4.454235572 4.762576969 3.66030209 5.983911455 7.022262395 hsa-miR-369-5p_st 2.816605982 3.429502238 2.967445772 2.041933545 3.902130115 4.573546486 5.92064661 hsa-miR-369-3p_st 0.584522362 0.527524997 0.435511191 −0.21088085 1.555950965 0.838843072 0.149038903 hsa-miR-370_st 10.66250198 10.19542595 9.934866716 10.41134399 10.49497141 11.66197987 11.15441774 hsa-miR-371-5p_st 11.46805808 10.65296546 10.84385006 11.0967639 11.3071377 12.40076071 11.59256738 hsa-miR-371-3p_st 4.428684445 4.00951213 2.927362451 3.780362405 4.951871521 3.672238769 3.593820418 hsa-miR-372_st 3.383842566 2.932912173 2.695467555 2.868907903 2.911392346 3.410624225 2.083169638 hsa-miR-373-star_st 10.44198357 9.834390326 9.660602823 10.18923427 10.24367291 11.50611211 10.8012473 hsa-miR-373_st 4.68157357 4.667159466 5.347240899 4.898623484 5.760515338 4.188565291 3.565890765 hsa-miR-374a_st 2.746352732 2.101453857 4.790475604 4.987806416 3.68464203 1.55251603 2.308989051 hsa-miR-374a-star_st 2.359595217 2.707385191 3.277990385 2.993706106 1.462605794 1.989512609 2.472470429 hsa-miR-375_st 3.686513562 6.426353038 6.137216321 8.152571828 4.938681056 5.561218031 11.10838014 hsa-miR-376a-star_st 0.245067577 0.71757059 0.377714058 1.031179431 0.394770958 −0.486256129 0.297106535 hsa-miR-376a_st 3.241543741 4.201065686 3.424938745 3.19523485 3.538782724 4.01732044 5.004864937 hsa-miR-377-star_st 3.761491855 3.885023279 4.217497117 4.151183189 3.90914576 4.090239155 5.01639604 hsa-miR-377_st 2.017976063 2.501149813 2.461234646 2.99185006 2.074998783 2.653150198 3.238371152 hsa-miR-378-star_st 4.936781413 5.157465089 5.063804703 4.719172179 5.30446115 5.129536145 5.168817953 hsa-miR-378_st 8.67122022 7.99057416 8.609338708 8.587733241 8.907842308 9.040023431 8.808561769 hsa-miR-379_st 5.056938067 4.739756204 5.49523466 5.597989582 6.258519917 5.211109664 7.062890441 hsa-miR-379-star_st 2.332267711 2.481254736 1.336725792 2.563032243 0.97963515 1.601561422 3.006174657 hsa-miR-380-star_st 2.500714412 1.249601515 2.216234747 1.44333619 2.22407685 1.298198913 2.368648228 hsa-miR-380_st 1.522644209 0.714126368 −0.175728294 0.564272055 −0.332641745 0.974600959 1.349426779 hsa-miR-381_st 5.195650439 5.258783721 4.329945176 4.302408997 6.312257649 5.895777269 5.871400479 hsa-miR-382_st 6.376664164 7.003910777 5.929397284 6.085575512 6.076890881 6.521354915 8.654419679 hsa-miR-383_st 6.150586869 5.482646286 5.883540209 5.206614207 6.797733986 5.654344534 4.991290529 hsa-miR-340_st 2.739748114 4.226724273 4.888614384 5.626948873 4.294456897 3.151236965 3.7316651 hsa-miR-340-star_st 1.105858998 1.868313575 1.909870054 1.003833926 2.432430935 0.75420138 1.390787536 hsa-miR-330-5p_st 5.543035505 6.00995518 5.169021449 5.431741752 6.380199848 6.063818017 6.123791792 hsa-miR-330-3p_st 5.877504201 5.899891653 7.128009078 6.079233466 5.952005285 6.094368129 6.604788802 hsa-miR-328_st 8.023271414 6.94536591 6.754418019 7.908697225 8.042126529 7.70300363 7.701877459 hsa-miR-342-5p_st 6.013896834 5.130002933 5.635206131 5.654050909 3.250929013 4.970118357 4.892404436 hsa-miR-342-3p_st 11.18782558 10.33383011 10.55575686 11.04744498 9.716525489 9.987005921 10.72063988 hsa-miR-337-5p_st 3.11616758 2.495193726 2.529643134 2.711052765 2.407500661 2.184134061 4.933427389 hsa-miR-337-3p_st 4.192662148 4.163497455 4.241856453 3.338704997 4.729829498 3.458832889 3.928510968 hsa-miR-323-5p_st 10.68533297 10.43832356 9.988308198 10.55372502 10.39694144 10.83355004 11.2476582 hsa-miR-323-3p_st 3.172662581 3.917278932 3.518027496 4.338639515 2.871411534 3.898537407 5.079618197 hsa-miR-326_st 7.189387683 6.434684307 6.521292472 6.97468923 6.62066558 6.132429218 6.844870951 hsa-miR-151-5p_st 10.84197149 11.23883523 12.76668197 12.60927027 9.914487993 10.4084821 11.19280892 hsa-miR-151-3p_st 8.067053149 8.23323805 9.960454629 9.933906889 6.58645934 8.707401804 8.466364616 hsa-miR-135b_st 0.920062746 1.906618649 3.15237334 3.467772674 2.708207518 0.611852554 1.322383227 hsa-miR-135b-star_st 5.779762829 6.185345105 5.901408556 6.116182373 6.817866651 6.725849204 6.054944542 hsa-miR-148b-star_st 2.113008009 2.469794658 2.480660288 3.105552475 2.645119452 1.371280818 1.263135905 hsa-miR-148b_st 7.552957328 8.728074879 9.789143638 10.61861591 6.207270443 6.554188772 8.7554851 hsa-miR-331-5p_st 5.84637556 6.058363224 6.880749831 6.007233777 6.287541051 6.479721079 5.885213925 hsa-miR-331-3p_st 8.43599499 8.871346705 10.78920451 10.73465829 8.121097469 7.973937898 9.827228306 hsa-miR-324-5p_st 7.657052602 8.452394225 10.09490014 9.7779192 7.348160894 7.899566703 9.009269421 hsa-miR-324-3p_st 7.826858127 7.999003888 9.107038126 8.270187988 8.282632625 8.008809916 7.74731467 hsa-miR-338-5p_st 4.561652104 5.187278435 6.573332418 6.152560126 5.237665476 5.282553326 4.830155015 hsa-miR-338-3p_st 3.374302226 3.761520049 6.700619906 6.527609825 4.508076527 2.889486257 3.9678053 hsa-miR-339-5p_st 7.969051484 7.796328417 8.765662152 8.200420366 7.351144211 8.086352477 7.718630707 hsa-miR-339-3p_st 8.3692502 8.607951369 8.899536514 8.764571056 8.068342249 8.436200024 7.943722012 hsa-miR-335_st 7.671713581 8.287737938 10.39543188 9.848927583 7.228803961 6.102533735 10.15294873 hsa-miR-335-star_st 4.082026326 2.361811507 3.225032342 3.793966342 4.624678977 1.814977209 2.87063635 hsa-miR-133b_st 4.414634066 5.210705263 5.682681058 5.547738416 4.21831562 3.997423643 5.298707856 hsa-miR-325_st 3.853904368 3.257803028 3.604437494 3.418319871 3.743732192 3.255085399 4.244909852 hsa-miR-345_st 9.373440995 9.480434043 12.28027146 11.41637476 9.079104101 8.409632131 5.980464413 hsa-miR-346_st 8.784388859 8.167658397 8.205981074 8.158354848 8.900148273 8.967807936 9.339839674 hsa-miR-384_st 0.842931018 1.258444499 0.95981369 0.678065129 −0.147713731 0.155753324 0.479215017 hsa-miR-196b_st 1.76546443 2.531502363 3.205204927 2.805552739 2.728638755 1.928151386 1.71009496 hsa-miR-196b-star_st 5.779327792 6.178843645 5.654104379 5.792737568 6.210381189 6.491260119 6.246087963 hsa-miR-422a_st 8.459954474 8.377322163 8.533880591 9.237399557 9.619792287 9.062528905 9.037294785 hsa-miR-423-5p_st 12.89182799 12.62140973 12.4055162 12.54246929 12.86180596 13.35382633 13.138973 hsa-miR-423-3p_st 9.063235932 9.185441861 10.64425982 9.719892765 8.924912467 8.963259279 9.506448899 hsa-miR-424_st 4.882868691 6.295135013 7.994906891 10.84215501 5.46745459 5.834776276 3.70676654 hsa-miR-424-star_st 8.029179231 8.043883588 8.337879539 9.271244311 7.478962877 8.29953306 7.305267459 hsa-miR-425_st 8.582498398 8.352634808 10.30500075 9.41102455 8.140395514 9.341932874 8.396795161 hsa-miR-425-star_st 8.098387011 7.932382183 7.829302142 7.532967708 7.438925211 8.533314119 8.000824764 hsa-miR-18b_st 4.499532941 3.728748147 4.786809911 4.110511493 4.186012317 3.601074213 2.735250315 hsa-miR-18b-star_st 4.287819139 4.077068701 4.43673482 4.765473323 4.963154947 4.650173468 4.400712134 hsa-miR-20b_st 7.865800708 8.202315551 9.532464877 9.788243423 7.569925978 7.566182684 6.843484444 hsa-miR-20b-star_st 4.143627157 5.030917652 4.206523494 5.175876296 5.05688342 4.974647314 4.459519972 hsa-miR-448_st 2.162557404 2.214686596 2.13922308 2.774330799 2.538956688 2.210529503 1.720363848 hsa-miR-429_st 4.241260167 6.081711471 5.577460139 7.480276828 4.434648205 3.527725747 5.935416594 hsa-miR-449a_st 3.045092947 3.665909815 3.456066367 3.1817055 3.711956766 2.698347049 2.48748893 hsa-miR-450a_st 1.536042121 3.616575704 4.144006502 5.168090675 2.83111974 1.897887798 2.184613142 hsa-miR-431_st 2.915260253 2.755098244 3.288321387 2.74860232 2.483698739 3.580672381 2.944661195 hsa-miR-431-star_st 5.505880555 6.038798865 5.880931061 6.244159874 6.812791054 6.629710406 7.124071842 hsa-miR-433_st 5.517735236 4.554620367 4.395937844 4.312870005 4.893548608 5.397555859 6.951844216 hsa-miR-329_st 3.398369888 3.510061867 3.285220855 2.868015751 3.671430905 3.772272093 6.797868256 hsa-miR-451_st 12.96940173 11.82769992 13.0955659 14.19532705 9.950243634 11.81095118 10.98415674 hsa-miR-452_st 5.710855215 5.595672484 7.330620363 7.74641091 7.445811206 6.721417294 6.17210208 hsa-miR-452-star_st 3.528180907 3.615676975 2.71971657 3.132175727 2.842837796 2.856532589 3.529203911 hsa-miR-409-5p_st 3.374220979 3.169664112 3.45247325 3.947970815 3.349906107 3.50555313 5.245901773 hsa-miR-409-3p_st 5.729595433 5.453170437 4.543197836 5.391541448 6.291002505 7.390994388 7.780689088 hsa-miR-412_st 3.853293934 4.254169686 4.474206596 4.170368141 4.989744029 4.541766664 3.938177965 hsa-miR-410_st 3.72222715 3.670557803 3.258032713 2.91539165 2.903733938 3.484047063 5.408722177 hsa-miR-376b_st 2.048566137 2.729773534 1.641543446 2.68496279 1.437631545 2.482683177 3.602866796 hsa-miR-483-5p_st 10.9378543 10.8656964 10.71265813 11.03548838 11.09259711 11.58218504 11.45556196 hsa-miR-483-3p_st 6.665855363 6.316505497 5.951720747 6.316170882 6.850657716 7.20191699 7.033686048 hsa-miR-484_st 6.913860167 6.786655549 8.619578993 7.127768873 6.55347334 7.193164653 7.974155786 hsa-miR-485-5p_st 5.94920657 5.676783967 5.581727432 5.613559599 6.384470949 6.322337878 7.407799826 hsa-miR-485-3p_st 5.291253144 4.907830691 5.659977304 4.972062969 5.999860274 6.003767517 5.690373839 hsa-miR-486-5p_st 8.69158319 7.174199322 7.760496764 8.886961688 7.276771701 7.586422584 8.491068116 hsa-miR-486-3p_st 9.954956254 9.010921276 8.727808912 9.299464961 9.553294049 10.11271732 9.965941934 hsa-miR-487a_st 5.623884505 4.975835559 4.93582479 4.916795819 5.852231815 5.57826735 5.763071109 hsa-miR-488-star_st 2.500680883 2.381066254 1.973024867 2.332466917 1.895005876 1.321182229 2.035841781 hsa-miR-488_st 2.62719596 2.316401956 2.348805102 2.271105315 1.122737217 1.885344241 1.725288171 hsa-miR-489_st 7.508636931 7.282778511 7.967696477 8.419882862 9.129564931 8.874439074 9.15128658 hsa-miR-490-5p_st 6.63468389 6.029808769 6.071069604 5.980226978 6.734694937 7.554556125 7.686641955 hsa-miR-490-3p_st 5.082500625 4.652859918 4.195431463 4.747161999 5.2866652 5.649061601 5.248693968 hsa-miR-491-5p_st 9.132643854 8.112016789 9.536157287 8.948854356 8.598623181 8.952183645 9.462878083 hsa-miR-491-3p_st 5.54326012 4.65990261 4.932498107 4.469863838 5.398481819 4.864612776 4.335984162 hsa-miR-511_st 0.839436228 0.113024582 2.244800081 0.282334695 1.693281708 −0.347514889 0.83389021 hsa-miR-146b-5p_st 10.52057441 14.70966445 12.5161599 14.32373111 8.454725246 13.37425573 8.075023822 hsa-miR-146b-3p_st 4.719539775 7.799741716 5.880215126 7.941664517 3.481937957 6.03691075 2.720996282 hsa-miR-202-star_st −0.710354353 0.11688602 0.110264034 −0.058861623 −0.086572407 0.429165649 −1.034188406 hsa-miR-202_st 8.374365459 8.118762885 8.061756989 7.908788593 8.604166618 8.405821408 8.630164513 hsa-miR-492_st 7.629427245 7.426256936 7.163710438 8.22053489 8.105177913 9.051248437 8.499085675 hsa-miR-493-star_st 3.487163308 4.345678887 4.011155197 3.855518329 4.298424359 4.712630615 4.227656678 hsa-miR-493_st 5.385862991 4.795534507 5.101901016 4.735788463 4.868820869 5.310596275 4.890299928 hsa-miR-432_st 6.54502925 6.003396028 6.412921209 6.410218113 7.38860191 6.965490916 8.774912478 hsa-miR-432-star_st 4.596185241 4.302474656 4.444028932 4.320177292 5.384393998 5.244918718 5.33587688 hsa-miR-494_st 13.98461275 14.88118304 14.42031419 15.12039241 14.52981296 15.6143693 15.53535125 hsa-miR-495_st 2.262903045 2.734790533 2.143386819 3.889029154 2.476828061 3.530585983 6.876033135 hsa-miR-496_st 0.472655191 1.643274745 0.299584845 1.603247092 1.643717548 1.359192885 2.288260374 hsa-miR-193b-star_st 11.01101258 10.62378697 10.26195889 10.47300255 10.6684967 11.54872907 10.94864216 hsa-miR-193b_st 8.435169833 8.163186009 8.985803483 9.670567235 6.18975779 8.675079249 7.392970829 hsa-miR-497_st 9.050640456 8.244639698 10.66736358 10.29175183 8.484254593 7.996287595 9.293549196 hsa-miR-497-star_st 1.643786965 2.047643771 0.979924947 1.876203663 1.496653186 2.117945865 2.494677383 hsa-miR-181d_st 8.420723783 9.41676115 9.827333839 11.43832275 8.048719709 8.857936017 8.506563185 hsa-miR-512-5p_st 4.586588427 4.291934453 3.468613759 4.596197901 5.00137836 4.196364425 3.957253756 hsa-miR-512-3p_st 4.395390302 4.35000214 4.216604755 3.456111122 4.385710511 4.211822087 4.219703533 hsa-miR-498_st 11.09428756 10.95435299 9.8331356 10.41129628 10.19214144 11.81207563 11.35393276 hsa-miR-520

_st 1.675954968 2.119538988 2.120835759 1.209729103 1.191246989 1.463702792 0.755242281 hsa-miR-515-5p_st 1.662186444 2.257666226 2.462623701 2.024098196 2.062043214 2.778166658 2.595360763 hsa-miR-515-3p_st 4.375396132 3.808048853 3.39352862 3.182907393 5.106154805 2.428022429 3.275411466 hsa-miR-519

-star_st 5.729696842 5.097101852 5.204551906 4.550616919 6.608884358 6.767449272 5.985567073 hsa-miR-519

_st 3.471908391 3.842707686 4.099387073 3.335056747 3.60342135 3.582457983 3.89475721 hsa-miR-520

_st 1.685083081 1.394834323 2.703273015 2.863401672 1.713775331 0.542016529 1.530500218 hsa-miR-519c-5p_st 5.406237378 4.186498999 5.110205282 4.490789316 5.670155936 5.747092568 5.910440404 hsa-miR-519c-3p_st −0.549794826 0.622617686 −0.33511625 −1.317412983 −0.483598918 −0.50596838 −0.136204987 hsa-miR-520a-5p_st 4.519500171 3.667123568 2.500904717 2.357004003 4.112836347 3.904275982 3.207414766 hsa-miR-520a-3p_st 3.10388247 2.000657387 2.901119578 2.846109152 3.679453058 1.691957609 1.843885913 hsa-miR-526b_st 4.949959327 4.459591212 4.674527623 4.444358449 5.686353998 4.431356481 4.420912356 hsa-miR-526b-star_st 0.60233174 1.155060732 2.186238509 −0.152210402 1.382461222 1.444201582 0.837489073 hsa-miR-519b-5p_st 5.764440067 5.153931951 5.253103802 6.056261066 6.217745987 5.721172117 5.571879494 hsa-miR-519b-3p_st 1.725319737 1.890360411 1.780752816 0.733844217 0.878526856 0.874462175 0.55147417 hsa-miR-525-5p_st 4.914893377 4.939616585 4.525264862 4.38321538 5.197370701 5.171392936 5.539146207 hsa-miR-525-3p_st 3.136624386 2.908171583 2.228155508 2.108242343 1.698417783 3.27746518 2.720377479 hsa-miR-523-star_st 5.641050698 3.878241586 3.859254339 5.070155783 5.42496753 5.707575993 5.032216476 hsa-miR-523_st 1.033488418 1.586070682 1.324662699 1.103658375 0.385425412 1.439021362 1.12957409 hsa-miR-518

-star_st 6.482487786 5.833422436 5.545088839 5.644723701 5.96857591 6.279083636 6.454918966 hsa-miR-518

_st 0.998159165 1.148713076 1.56831707 0.694297378 0.702306121 1.314675628 0.632210105 hsa-miR-520b_st 1.03456029 1.217354164 1.043293188 −0.03949637 0.515829828 1.108856635 1.138783346 hsa-miR-518b_st 3.438524426 2.717213079 3.075565546 3.049839255 2.920466083 3.565723937 4.380235243 hsa-miR-526a_st 6.032071983 5.072921146 5.879985174 5.67980207 6.689122741 5.989887504 5.963522371 hsa-miR-520c-5p_st 5.765271582 5.693138417 6.13562055 6.552868785 6.401170506 6.345762923 6.17289623 hsa-miR-520c-3p_st 2.247390942 3.446986383 3.226686882 3.629892063 3.379888391 2.997761269 2.476401929 hsa-miR-518c-star_st 8.147354578 7.078271483 7.932173465 7.615708413 8.45859527 8.381858995 8.396162316 hsa-miR-518c_st −0.777517245 0.6041063 −0.526736849 −0.231989003 0.518111246 0.119043374 0.086523521 hsa-miR-524-5p_st 5.459834811 4.504010275 5.193528956 4.932016145 5.194604662 4.262254725 4.347500832 hsa-miR-524-3p_st 2.735798049 2.915233161 2.781078582 1.836713128 2.866370074 2.651850418 3.326497246 hsa-miR-517-star_st 4.761400007 4.419790058 4.250741056 4.072639789 4.580273113 4.822990606 4.368774133 hsa-miR-517a_st 2.195131565 1.210558881 0.359337297 1.73778594 2.210479709 0.589857448 1.842891979 hsa-miR-519d_st 4.132793585 3.626304786 3.693808848 3.780643324 3.861885802 3.044223817 3.814302266 hsa-miR-521_st 2.489355502 2.722874793 3.086840786 3.554839091 3.123897523 2.738635801 2.730466676 hsa-miR-520d-5p_st 6.195598862 4.882337586 5.846500299 5.893878744 6.194230037 6.616149745 7.007784209 hsa-miR-520d-3p_st 5.323296403 5.699770398 5.191000218 4.372326295 6.419796604 5.469519667 3.952336282 hsa-miR-517b_st 2.760911435 2.926054466 3.233010063 2.55525226 3.364069447 2.291932494 2.580645489 hsa-miR-520g_st 2.369255034 1.914940511 2.616487955 1.525505264 3.180571513 1.433766715 1.873566369 hsa-miR-516b_st 5.882338411 5.510166251 5.857692753 6.502369011 6.70047697 6.514763305 7.211128145 hsa-miR-516b-star_st 2.801934818 3.321359042 2.660297327 3.63093769 2.177969079 2.791774524 3.144125074 hsa-miR-518

-star_st 6.199327696 5.56484411 5.939852567 5.447737281 6.28953341 6.017023596 5.708195652 hsa-miR-518

_st 2.469889705 1.625959269 2.524813956 0.298813904 1.160099192 1.442571747 1.322047396 hsa-miR-518a-5p_st 6.4065813 6.03862878 5.852241749 7.068438045 6.782664753 6.790318254 6.642328151 hsa-miR-518a-3p_st 3.009493472 3.049731066 2.797335983 1.918310434 3.685969858 2.902829381 2.950615287 hsa-miR-518d-5p_st 6.005551575 5.986588652 5.548331989 5.737001891 6.020136865 6.187263916 6.122531729 hsa-miR-518d-3p_st 3.033963685 2.856131336 2.311075845 2.069450896 2.771209718 3.207793422 2.597781453 hsa-miR-517c_st −0.189209395 −0.123112626 0.864703373 −0.568531577 0.665877394 −0.396534366 −0.543525556 hsa-miR-520h_st 3.501857005 2.322431935 1.558945645 1.509406498 2.729457706 1.159661952 2.364359378 hsa-miR-522-star_st 4.80791035 4.896525074 4.77136396 4.656568434 5.954806199 6.350870405 5.561035081 hsa-miR-522_st 2.226131081 2.337903259 1.531606335 1.357960144 1.617437867 1.846396545 1.931253577 hsa-miR-519a-star_st 5.582550105 4.354351578 3.686316205 4.313327802 5.884078752 5.867585927 5.287321982 hsa-miR-519a_st 0.248203506 −0.147905597 −0.525791863 −1.516950308 1.318269063 −0.341668399 0.22974033 hsa-miR-527_st 6.510959215 6.539492409 6.425150205 7.05391517 7.582825801 7.474668696 6.528886973 hsa-miR-516a-5p_st 7.088239464 5.918051974 6.10113407 6.304903174 7.645689315 7.502644792 6.969722152 hsa-miR-516a-3p_st 2.526175394 2.928041413 2.574533178 2.197902249 2.362803412 2.46902788 2.226040698 hsa-miR-499-5p_st 1.735921828 2.044475607 5.017299949 1.883292365 3.588723052 1.179388971 1.852773681 hsa-miR-499-3p_st 2.695462592 2.412555913 3.829239174 2.917713351 1.720955791 2.655627135 3.031909236 hsa-miR-500_st 6.115427242 5.62835908 7.429244352 6.412291828 5.313361614 6.964763976 5.313563745 hsa-miR-500-star_st 8.614855484 7.618592458 8.617485619 9.015593792 7.92392514 8.735283037 8.262721627 hsa-miR-501-5p_st 5.417892087 5.215368468 5.108110084 6.672488427 5.347400481 5.125839848 5.705047891 hsa-miR-501-3p_st 8.686883016 8.160224812 8.557588768 8.134681511 8.360146435 8.988086251 8.472333358 hsa-miR-502-5p_st 3.656195807 3.565752032 3.987136015 3.99529824 4.033136498 3.450045182 2.682136412 hsa-miR-502-3p_st 8.568606026 8.055237183 8.655385039 8.869641429 7.855702505 8.532227184 8.40085584 hsa-miR-503_st 10.05526134 10.1706024 9.413847157 10.1360777 9.361401731 10.41098089 10.5603285 hsa-miR-504_st 4.733945101 5.020624194 5.302854486 4.889820098 5.110689772 4.613444198 7.010663539 hsa-miR-505-star_st 7.70634597 6.47300211 6.994515549 6.20932306 7.609360342 6.799143364 7.799187604 hsa-miR-505_st 5.054478955 4.322556268 5.644079478 5.728498907 4.238066748 4.821662534 5.822139512 hsa-miR-513a-5p_st 12.01689483 11.58496937 12.52463938 12.55320373 12.72827673 12.986416 13.2956074 hsa-miR-513a-3p_st 1.016511924 1.141672097 0.129620969 1.693439417 −0.285468892 −0.146609393 2.030167931 hsa-miR-506_st 3.397460858 3.618035775 3.760978768 3.437165209 3.615280319 3.163944068 3.080310649 hsa-miR-507_st 1.100674178 1.004100805 0.60886341 0.54123601 −0.642894488 0.987745931 0.580257436 hsa-miR-508-5p_st 7.397868422 7.461686451 6.932265908 7.766250837 7.686883188 8.354051807 8.153664691 hsa-miR-508-3p_st 0.737446251 0.240671264 2.195973871 1.210963063 1.074518478 −0.942758103 −0.4641357 hsa-miR-509-5p_st 4.746801979 3.960726433 3.935030653 4.749178874 4.726133269 4.953843274 5.122556162 hsa-miR-509-3p_st 4.930815364 4.859305139 4.546538826 4.819761932 4.753935273 4.684626424 5.22752142 hsa-miR-510_st 7.352735486 7.002023174 6.864634879 7.073059844 8.01525399 8.44943122 8.275843102 hsa-miR-514_st 0.673418293 1.457188618 1.502887324 1.147143084 1.026837954 0.142984671 0.30282737 hsa-miR-532-5p_st 7.689369219 6.938208079 8.761787862 7.959027824 7.019139979 7.918420758 7.816276508 hsa-miR-532-3p_st 7.816436888 7.294434331 8.361100734 7.505876724 7.521743758 7.10706053 7.084561314 hsa-miR-455-5p_st 4.521412053 3.257983972 4.76537493 3.478305384 3.323378506 2.024253674 3.536649142 hsa-miR-455-3p_st 8.206693177 7.514317435 8.653915268 8.15463075 5.913146909 8.224099002 8.369132895 hsa-miR-539_st 3.153650763 3.379348904 3.618465698 4.58923712 4.098023517 2.670317037 6.000677123 hsa-miR-544_st −0.141359602 1.111510233 0.083093059 −0.383995203 −0.735306156 −0.368364077 0.098712429 hsa-miR-545-star_st 0.682048438 1.464484815 1.078180281 1.495054436 0.774006755 1.398538513 1.489820507 hsa-miR-545_st 0.868632223 1.208827741 0.679844962 1.257143574 0.456574965 0.613815493 0.466117673 hsa-miR-487b_st 6.996737933 7.38625027 6.745930614 7.792952177 7.444282099 7.604082287 9.649092395 hsa-miR-551a_st 3.946372902 3.778055745 3.909230297 3.791524174 4.910442287 3.943318951 4.238093192 hsa-miR-552_st 4.613782644 4.589706144 3.970053674 4.750346192 4.660621348 3.827499362 5.231974785 hsa-miR-553_st 1.735343108 1.772618625 2.864791347 2.363657481 3.361853896 2.145926338 1.317674988 hsa-miR-554_st 4.319162096 4.527996206 3.778726947 4.198853805 4.934639981 4.175954613 4.675567443 hsa-miR-92b-star_st 14.26896827 14.2551999 13.8539788 14.2035804 13.96380845 15.11340303 14.73220385 hsa-miR-92b_st 8.806231403 8.912214078 9.345529399 8.838861847 8.53259147 8.890814165 8.316847399 hsa-miR-555_st 3.623139219 3.154467464 3.83929359 3.489814694 4.036995081 3.397308061 4.035941073 hsa-miR-556-5p_st 0.954827423 1.10923269 2.015772652 2.016342979 −0.004490902 0.278540747 0.666758045 hsa-miR-556-3p_st 0.420972567 2.347393955 1.137077879 1.877233372 −0.058014804 0.656840155 1.003443138 hsa-miR-557_st 11.78996606 10.72289265 10.50920716 11.30501459 11.43225514 12.41063254 11.82504438 hsa-miR-558_st 1.23937357 1.824799535 1.871563193 1.539823914 0.891607833 0.905187829 1.814314038 hsa-miR-559_st 2.027442916 2.244306812 1.442942664 2.926935634 1.881057024 0.966171504 1.931322247 hsa-miR-561_st 0.525527386 1.398717571 0.044911966 0.488116646 0.064989008 1.744867685 1.374535555 hsa-miR-562_st 1.744592994 1.421181047 1.926107033 1.84997461 0.592225586 1.13183089 0.201682401 hsa-miR-563_st 2.823110138 2.818187645 2.058077479 0.574902877 2.772848127 2.841063867 2.901722703 hsa-miR-564_st 11.61571838 11.13188404 11.49093595 11.55048334 11.73302897 12.29933641 12.18463026 hsa-miR-566_st 7.421205274 6.875799367 7.121412317 6.832239534 6.796061261 7.116446456 6.96635027 hsa-miR-567_st 2.872484694 2.941223114 2.878808335 2.063521577 2.379389899 2.704682418 1.967826245 hsa-miR-568_st 0.841222709 1.003993292 0.268887928 0.408696941 0.320762432 1.370908157 0.180566245 hsa-miR-551b-star_st 10.144072 10.80207939 10.13827864 10.32452342 10.20140123 10.66845316 10.62981089 hsa-miR-551b_st 1.831658154 6.031653391 4.902501433 4.320087058 1.353296753 2.866569471 1.160939481 hsa-miR-569_st 2.059050402 2.197334883 2.111663405 2.605915412 0.954620449 1.822215514 2.393329094 hsa-miR-570_st 1.429336709 2.098681434 1.860837924 3.642386705 3.149490978 0.961394389 2.186083925 hsa-miR-571_st 3.380559295 3.932621755 4.05569966 4.219762216 4.02741426 4.051145852 3.674427609 hsa-miR-572_st 13.71328956 13.26232857 12.95563784 13.43772993 13.55392917 14.72647896 14.15597419 hsa-miR-573_st 0.915203499 0.538451784 1.314701061 0.487946924 −0.025999063 −0.327956891 0.369268137 hsa-miR-574-5p_st 8.174609455 7.129576405 7.638178162 6.590010225 7.816554564 7.683912518 7.239715927 hsa-miR-574-3p_st 9.354293239 9.366586673 9.811478169 9.79238808 8.68975847 9.323111322 9.696666588 hsa-miR-575_st 12.14134093 11.83164776 12.4880422 12.78663814 12.65936333 13.72040819 13.35082926 hsa-miR-576-5p_st 4.052735121 3.717853966 3.228303147 2.984571167 3.117416511 2.478943054 3.318799149 hsa-miR-576-3p_st 4.193011785 4.212058968 4.45060884 4.788974215 6.287818248 3.152824124 4.492082281 hsa-miR-577_st 0.024570477 1.039931121 0.770209806 0.689806029 −0.214009666 1.615514663 0.678151308 hsa-miR-578_st 2.988410084 4.032868967 3.955262144 3.12961382 3.13101188 2.674756648 3.147223288 hsa-miR-579_st 1.418868431 2.376228639 2.248171119 2.256512879 2.174676686 2.220716733 1.68647074 hsa-miR-580_st 1.791515535 1.09459287 0.72258462 −0.035363538 0.4917074 1.059918212 1.162670873 hsa-miR-581_st 0.7491545 −0.475220183 0.096158816 −1.386606475 0.387322965 0.618778518 −0.439336625 hsa-miR-582-5p_st 1.780259411 1.546873342 2.157961771 1.695210767 1.683379377 0.128053684 2.114597632 hsa-miR-582-3p_st 2.42975747 3.132402344 2.797576005 2.04520976 2.461344034 3.23704303 2.089123902 hsa-miR-583_st 6.437128467 5.298685748 5.365335413 5.609664047 6.068005233 6.532552101 5.570598399 hsa-miR-584_st 7.080132522 6.971329144 7.555048719 6.922772245 7.842862351 7.477167691 7.12596509 hsa-miR-585_st 3.01292581 3.10636595 2.491330782 3.123460879 2.600657745 2.938880313 3.197363501 hsa-miR-548a-3p_st 0.318523022 1.19009688 1.994197598 0.385254853 1.381379122 0.094641151 0.528920974 hsa-miR-586_st 1.279270963 1.792583007 2.204418094 2.263989756 1.354538991 0.88987338 1.661892417 hsa-miR-587_st 2.118818492 2.894049312 2.697376727 2.978405153 3.329280525 2.455720163 2.807680688 hsa-miR-548b-5p_st 3.734335891 2.757118192 4.041867641 4.024962717 4.291748511 2.109944618 1.643056814 hsa-miR-548b-3p_st 1.642453437 2.774159234 3.117411899 2.622291887 3.193940661 1.955213834 1.153854152 hsa-miR-588_st 4.29062919 4.720786655 4.983628933 4.968883971 4.736342406 5.211103331 5.195347532 hsa-miR-589_st 3.887558236 3.883264401 3.023904246 3.037780882 4.25144117 3.611549864 3.27318682 hsa-miR-589-star_st 4.799672458 4.795739846 4.833408782 3.827913515 5.52340674 4.917918559 4.965984889 hsa-miR-550_st 11.16428246 10.40434353 10.95939665 11.16521616 11.59810924 11.66224552 11.90658708 hsa-miR-550-star_st 4.166682298 4.581326751 4.984841508 4.010560427 4.887346146 4.525312343 3.860527763 hsa-miR-590-5p_st 2.197286679 2.438730482 2.523408476 1.981748267 2.752292563 0.836372605 0.95864178 hsa-miR-590-3p_st 1.257587867 1.241829502 −0.105779452 0.860934071 0.484016233 0.994981194 0.168746252 hsa-miR-591_st 2.783823616 2.474387368 2.909320393 1.791175076 2.866647577 1.706979281 1.287035249 hsa-miR-592_st 1.84097372 0.672747337 1.484629064 1.315995386 2.503190344 0.455950787 2.085752662 hsa-miR-593-star_st 9.332162645 8.114067792 8.21033438 7.65692913 9.410123896 8.79398727 8.9833194 hsa-miR-593_st 5.828127858 5.800627487 5.90187003 5.565114451 6.332444763 5.505037721 4.21496538 hsa-miR-595_st 7.351906685 6.790181727 6.997603857 7.031769941 7.128351546 7.282898507 7.177527435 hsa-miR-596_st 7.861566113 6.632444124 6.961116656 7.374355474 7.660386225 8.160538384 8.195744521 hsa-miR-597_st 2.436971759 1.581016067 1.677023261 1.461927199 0.905204105 1.772202005 1.099577698 hsa-miR-598_st 5.331619976 5.720871401 7.434135124 7.968328453 5.348142934 4.250945032 7.347296647 hsa-miR-599_st 1.586356324 1.564198749 2.09465854 2.389020175 1.651481111 1.004264288 1.097614472 hsa-miR-548a-5p_st 3.635285076 4.431005765 4.113932028 4.69344434 3.655750515 4.042241667 4.044894771 hsa-miR-600_st 5.465360277 5.660066921 4.725298299 4.571524582 5.416411683 5.526296346 4.043056928 hsa-miR-601_st 5.627316069 6.089278354 4.697206951 4.791263503 6.524982459 5.948292481 5.524552246 hsa-miR-602_st 13.15090327 12.89815612 12.19107695 13.07171216 13.04329751 14.03002919 13.63949319 hsa-miR-603_st 3.536959524 1.875330278 2.419784634 2.371923729 2.375770845 0.386410684 0.728060881 hsa-miR-604_st 8.273628962 8.061633592 8.370017987 8.984732027 8.032766566 9.465384586 9.203509967 hsa-miR-605_st 6.137813329 5.212763587 5.27613191 3.435614661 6.17463945 5.852856363 5.206011824 hsa-miR-606_st 1.617429852 2.102062071 2.632477803 2.525372986 1.250412158 1.506709577 1.482482286 hsa-miR-607_st 2.343004256 2.994529175 2.635818339 3.118019176 1.418068623 2.583979837 2.092793802 hsa-miR-608_st 8.877024008 9.062934221 8.919377674 9.074302895 9.379407418 9.463746519 9.499801629 hsa-miR-609_st 2.84304626 2.923296145 2.424579692 2.24317475 2.406284424 1.390437928 1.49318755 hsa-miR-610_st 5.274501112 4.556253312 5.635909227 5.269175438 5.008994342 4.860049194 4.895667052 hsa-miR-611_st 7.633488225 6.215205355 7.146574667 6.797561515 7.623934664 8.166107899 7.352309843 hsa-miR-612_st 11.54291563 10.16311536 10.91953569 10.90287527 11.73181419 11.89999505 11.82806173 hsa-miR-613_st 3.62040995 3.841091303 4.625743676 4.080908351 4.366156616 3.388841376 3.413393802 hsa-miR-614_st 5.812001508 5.437330343 4.473376578 5.494611952 5.700395066 6.643097642 6.307541562 hsa-miR-615-5p_st 10.57918769 9.833331791 9.7623915 9.883754278 10.54857436 10.98987694 10.93498938 hsa-miR-615-3p_st 7.573934471 6.138085639 6.205335604 7.730413305 6.886265114 6.976313035 6.841559235 hsa-miR-616-star_st 4.499478979 4.656314984 3.985019577 4.253940162 4.802356869 3.443595469 3.436301985 hsa-miR-616_st 7.600061873 6.773423822 6.877939268 6.323385517 7.94386325 7.031291407 7.170596487 hsa-miR-548c-5p_st 8.625708585 8.118960159 8.707674975 7.664363464 8.655909164 6.318980618 6.003063976 hsa-miR-548c-3p_st 1.110706338 1.328843738 0.4863786 0.666563166 0.992594083 0.327774959 1.101654274 hsa-miR-617_st 5.302938397 5.569821714 5.018231274 5.390432001 6.811839293 5.48495218 5.964345857 hsa-miR-618_st 3.182785655 2.898692146 2.850006572 3.503150818 4.305498338 1.794159357 3.48606908 hsa-miR-619_st 3.665468574 3.785546152 3.683794292 3.083758024 3.818686757 3.909754737 3.707512244 hsa-miR-620_st 2.44025913 3.040608004 2.026886071 2.181694881 3.005367974 2.318672573 2.464278035 hsa-miR-621_st 3.719083689 3.382126279 3.217000018 2.541344354 3.440252944 2.936676434 3.194331179 hsa-miR-622_st 8.642610505 8.166661704 8.616923443 9.043206419 9.285747076 9.380614396 8.913270568 hsa-miR-623_st 8.569399854 8.040030533 7.952447719 8.440211545 8.306041408 9.517905604 8.912827573 hsa-miR-624-star_st 4.291064737 3.883820202 3.428780769 2.978121524 3.792996738 3.699412479 3.094544016 hsa-miR-624_st 2.978046143 2.796435163 1.787087296 2.458950893 1.411996277 2.661219971 2.692581166 hsa-miR-625_st 6.871307101 6.527948101 7.297107814 6.469159169 6.831217039 6.524150093 6.21824841 hsa-miR-625-star_st 4.576422678 3.018605998 3.802362362 2.797049012 3.678003952 3.870741947 3.835916538 hsa-miR-626_st 0.714596607 1.775193777 2.459703882 2.305714218 2.55770444 2.088218522 1.363835842 hsa-miR-627_st 1.431712781 1.657261287 1.32251047 1.173781862 0.283398022 0.595399103 1.609555357 hsa-miR-628-5p_st 1.856465736 1.958409645 2.990632861 2.240612964 2.235299217 2.182061249 2.17672931 hsa-miR-628-3p_st 9.125401099 8.349944068 9.598077304 9.829492208 10.10309557 10.05817015 9.874305754 hsa-miR-629_st 7.225504218 7.745354517 7.834408609 8.627683281 6.861469686 7.641208121 7.603599999 hsa-miR-629-star_st 5.748524211 5.243198805 5.156274568 5.352960855 5.313647678 4.992653128 4.481839114 hsa-miR-630_st 6.485579016 5.428255658 5.945747534 5.278760897 6.916335845 7.976016256 6.973217804 hsa-miR-631_st 6.422610303 5.74323599 5.979011349 5.772490551 6.204126669 6.763590719 5.880281471 hsa-miR-33b_st 1.594267299 1.134749481 1.380759324 1.660417239 0.656050831 0.219507921 −0.325445503 hsa-miR-33b-star_st 6.427703381 5.726989374 6.072573525 5.934780525 6.172740449 6.912862072 6.720499911 hsa-miR-632_st 4.26307099 3.384095517 4.938680281 4.578246658 4.282751828 3.32925136 3.40745619 hsa-miR-633_st 0.891478443 2.429348457 0.954422618 1.40576831 1.668639943 1.493379171 1.561699059 hsa-miR-634_st 5.860920829 5.810171457 5.812635519 5.353943851 7.020365158 4.471178928 4.969976182 hsa-miR-635_st 4.533979501 5.259604756 3.85885678 4.984546224 5.196680422 4.21820803 3.859246708 hsa-miR-636_st 8.946469281 8.384034046 7.523284321 8.635086475 8.679252266 9.676805929 9.431240623 hsa-miR-637_st 12.23726549 11.73601894 11.38069999 11.7179655 11.99334681 12.50436026 12.47145251 hsa-miR-638_st 15.51481568 16.2473256 15.31212226 15.49869309 14.53321459 15.83136002 15.71068299 hsa-miR-639_st 8.292126969 7.832611502 7.463580326 8.2048689 8.693443021 9.020292548 8.72419512 hsa-miR-640_st 6.676006823 6.475776455 5.524015524 6.274460174 6.49079198 6.451735732 7.041966752 hsa-miR-641_st 3.622857483 3.311325204 3.073800633 2.892273963 3.81889203 2.866898993 3.486859931 hsa-miR-642_st 3.594145741 3.542538841 3.323983635 3.310550527 4.741299326 2.742469227 4.115737103 hsa-miR-643_st 1.88652457 1.616446441 2.238630498 2.506634027 1.824814819 2.110146211 1.952078318 hsa-miR-644_st 2.437943686 2.128516964 2.67245495 1.184166214 2.281244501 1.683423942 0.63748629 hsa-miR-645_st 2.949351982 2.12732061 2.61177189 3.461361109 2.570170393 3.665325806 2.453147856 hsa-miR-646_st 2.942679033 3.592030927 2.8908041 3.294284003 2.816545338 2.570405234 3.449108798 hsa-miR-647_st 6.077940692 5.067515565 4.503260575 5.309295877 5.67896594 4.392055873 4.685470695 hsa-miR-648_st 7.279707849 7.185651907 6.970137345 6.50069676 7.243415957 7.72502138 7.886615472 hsa-miR-649_st 4.905834189 4.087821649 5.239081728 4.629922998 5.240424457 2.618649422 2.773472447 hsa-miR-650_st 10.67361231 9.154659886 9.987968893 10.01782265 10.85943975 11.17961851 10.19646105 hsa-miR-651_st 0.31611231 0.798286945 0.583001679 −0.014842326 0.143785414 0.972959323 1.952648617 hsa-miR-652_st 7.450767149 7.03317083 8.24475439 7.599168124 7.674285338 6.604032907 8.339292538 hsa-miR-548d-5p_st 7.524343032 6.484600725 7.939994823 6.244845357 7.762601635 5.718696533 4.639829452 hsa-miR-548d-3p_st 1.636809693 2.526720726 2.789680332 2.296207428 1.893897802 1.285495338 1.890100929 hsa-miR-661_st 7.612861528 6.413613372 6.69074105 6.659990028 7.614260745 7.298928723 6.558911334 hsa-miR-662_st 6.11976633 6.44608912 6.76443855 5.926590827 6.08841694 6.301181394 6.269652085 hsa-miR-663_st 15.22126025 15.6519729 15.04527593 15.40562496 14.53350071 15.83052149 15.57890658 hsa-miR-449b_st 4.676952894 5.299151435 4.921417799 4.594422 5.025669722 4.585845192 4.748592436 hsa-miR-449b-star_st 7.674329433 7.239350928 7.137335961 7.997913975 7.693145608 7.495554124 7.364270467 hsa-miR-653_st 0.29098795 1.830693654 0.207961931 1.872402808 −0.66983009 0.306524379 0.853540575 hsa-miR-411_st 3.675302593 3.02096103 2.962308284 3.419316101 2.480368443 3.454803377 4.974721301 hsa-miR-411-star_st 3.585204222 3.769389512 4.094779996 3.867622112 4.153818767 3.85823412 3.672295845 hsa-miR-654-5p_st 10.89687384 9.956949848 9.548772041 9.903340007 10.51933652 11.32770137 11.28177457 hsa-miR-654-3p_st 3.529801042 2.867773379 3.63431131 2.70532274 4.321342493 5.233089123 5.712914245 hsa-miR-655_st 0.683665929 1.444516254 1.261843693 1.540178957 0.355206552 0.998566646 0.611942618 hsa-miR-656_st 2.483428501 2.553678605 2.580217036 2.386504193 2.20237361 1.458517042 2.02155612 hsa-miR-549_st 2.565386727 2.26205593 2.667043567 2.383707078 2.297376334 2.211233738 2.280250463 hsa-miR-657_st 4.285194365 4.329163626 4.262950773 3.530581224 3.682643693 3.731013551 4.554679608 hsa-miR-658_st 11.76238903 11.37030017 11.37636624 11.36001273 11.12683658 11.97473325 12.2603194 hsa-miR-659_st 10.78477061 9.689560107 9.69071639 10.00967777 10.20855818 11.08369834 10.73305553 hsa-miR-660_st 6.91351322 7.165370671 8.217642038 7.915878655 6.631565089 5.944121769 6.208002101 hsa-miR-421_st 6.292083739 6.541192276 7.040990232 7.256618274 6.24272431 5.911003491 6.983259903 hsa-miR-542-5p_st 7.538601115 7.430618497 7.483102683 8.738682299 7.125946488 7.135160862 7.517791184 hsa-miR-542-3p_st 5.992649971 5.427924897 6.184252194 7.740176207 6.378661276 6.016607322 5.221555897 hsa-miR-758_st 2.356753045 1.915534234 0.987204286 2.981493291 3.452297929 3.397588165 3.612410114 hsa-miR-1264_st 2.373729404 2.668659426 3.031760709 2.651096276 4.186456349 1.894568394 2.040723758 hsa-miR-671-5p_st 11.2166394 10.50533991 10.76897197 10.62282309 11.14212132 12.10912696 11.67985263 hsa-miR-671-3p_st 6.76424341 6.527312033 6.795322889 5.364176729 6.791221173 7.066787233 7.308369973 hsa-miR-668_st 8.166866106 7.541167752 7.537283571 7.573939927 7.783709078 8.122397637 8.497071384 hsa-miR-767-5p_st 3.093920954 3.059321236 2.318376524 2.742392556 3.885189876 2.94276661 2.336666396 hsa-miR-767-3p_st 2.907468673 2.146622261 2.765413149 3.423100097 3.569948578 2.661450064 1.625299882 hsa-miR-1224-5p_st 12.63962093 12.30011815 12.10505473 12.48549894 12.65197772 13.81310379 13.41424396 hsa-miR-1224-3p_st 5.148364882 5.067414265 5.025677061 5.312534298 5.901404217 5.305855073 6.110508956 hsa-miR-320b_st 11.34828284 11.0320645 11.83049238 11.08969333 10.94293063 10.95823093 11.0179839 hsa-miR-320c_st 10.83115587 10.79043387 11.40979838 10.81243036 9.846536697 10.6228549 10.54496136 hsa-miR-1296_st 6.94929788 6.219152246 5.926965222 7.1215218 6.34744579 6.706243975 6.574410089 hsa-miR-1468_st 5.728014571 5.152276148 4.48270612 5.432003774 6.106457987 5.790944847 6.098629129 hsa-miR-1323_st 7.296208168 7.151319376 6.560656612 7.365533388 7.559942946 7.756625817 6.946026848 hsa-miR-1271_st 6.686845344 6.467967216 6.574415452 6.706215066 7.065287613 7.20091514 7.119404754 hsa-miR-1301_st 8.084569985 7.108185328 7.578494602 8.017643584 8.055483672 8.629387415 8.414236051 hsa-miR-454-star_st 1.239092419 2.077953993 1.657948294 3.337385718 1.27070949 0.976904255 2.045022086 hsa-miR-454_st 4.176676364 4.753369128 6.794563918 6.533331517 3.749690497 4.104854563 4.966299313 hsa-miR-1185_st 0.826857153 1.192026612 1.151480351 0.544278827 0.286042437 0.450648889 0.979244433 hsa-miR-449c_st 6.645129375 5.970884399 5.436798472 5.661979285 6.889171256 7.531881047 6.04504776 hsa-miR-449c-star_st 3.539802311 3.387327209 3.629923134 3.82373556 4.607836709 2.910863582 3.13177466 hsa-miR-1283_st 1.789740947 2.204471677 1.736329224 2.884920933 2.94052832 1.637115039 2.363002158 hsa-miR-769-5p_st 6.760567422 6.75614509 7.890262132 6.251294397 6.814134375 7.274034493 6.888648694 hsa-miR-769-3p_st 9.516922051 8.702776821 8.855037655 8.849180626 9.280707277 9.643072794 9.585431556 hsa-miR-766_st 7.884016592 7.4793299 7.315786363 7.636174948 7.955034501 7.976051989 7.344995225 hsa-miR-762_st 15.32478604 15.96368556 15.29530767 15.49841851 14.53399291 15.83120318 15.70978622 hsa-miR-802_st 1.152737519 1.736079043 −0.026235431 0.079138161 −0.157472091 0.095142909 1.430155661 hsa-miR-670_st 4.38787298 4.136177353 5.041062019 4.611749446 4.618876664 3.699027129 4.315760354 hsa-miR-1298_st 4.030354023 3.874375872 3.952001842 4.002448406 4.510695602 3.886093541 4.364631887 hsa-miR-2113_st 6.210884603 5.657316496 5.301636981 5.50045067 5.665891555 5.394681433 5.167143478 hsa-miR-761_st 7.353817523 6.477147623 6.964975682 7.149223486 7.882177289 7.564286267 7.249536399 hsa-miR-764_st 5.85455759 4.925197354 5.375425594 5.15940143 6.039439423 5.775061059 5.357170518 hsa-miR-759_st 1.055534708 1.966177208 1.118481697 1.922079508 1.264361104 2.818703892 −0.334985355 hsa-miR-765_st 7.935969438 8.066777002 8.777468432 8.734867122 9.303377607 8.882514331 9.368641279 hsa-miR-770-5p_st 6.60960487 6.199135255 5.9966288 6.449524499 6.594717781 6.485427675 5.860416893 hsa-miR-675_st 13.19734892 12.49017431 12.64268068 12.58654091 12.85752223 13.69886219 13.42561372 hsa-miR-675-star_st 6.349648086 6.301195437 5.325734291 6.864306949 7.01236302 7.839194365 6.504058662 hsa-miR-298_st 9.86200511 9.243125847 9.503658689 10.16355024 9.842704559 10.68087216 10.50549213 hsa-miR-891a_st 6.485438184 5.998112292 6.343441571 5.660959262 6.448875055 6.128087718 8.623106865 hsa-miR-300_st 5.214506346 4.772604338 4.67253437 4.499143644 5.495126266 4.840401035 5.231660564 hsa-miR-886-5p_st 11.75223698 11.57501668 10.56355167 12.10515393 11.01041386 12.14903466 12.12630147 hsa-miR-886-3p_st 9.641649359 9.994555728 9.518346438 11.31319403 8.967143143 11.01698561 10.33262396 hsa-miR-892a_st 4.729286441 3.738034823 3.640155623 3.585331961 4.670721249 2.651455468 5.049494031 hsa-miR-220b_st 3.707205793 3.59884387 3.547979065 3.073998958 3.715838095 2.564431385 3.120227978 hsa-miR-450b-5p_st 0.676718281 1.021609875 0.705111228 −0.134594011 2.114140843 0.309320889 −0.029960092 hsa-miR-450b-3p_st 0.951900349 1.64388678 0.48353567 0.171237495 0.756576061 0.461603648 0.288112462 hsa-miR-874_st 11.98068336 11.27985073 11.93202627 11.73980948 11.93944802 12.77845115 12.17761583 hsa-miR-890_st 6.15054768 5.855085113 5.837506751 6.050968077 6.185355794 5.596077845 7.181132662 hsa-miR-891b_st 3.122597921 3.288394888 3.694607668 2.762275343 2.440615367 3.051339285 5.018197032 hsa-miR-220c_st 6.07010339 4.910335716 6.1408178 5.753228908 6.993546786 5.866489448 5.999797051 hsa-miR-888_st 1.696069021 3.018200648 1.576282828 0.563992224 2.307508038 0.994823711 4.1520701 hsa-miR-888-star_st 1.377590098 0.59327829 1.351050351 1.620999064 0.647062406 0.871178503 1.16920787 hsa-miR-892b_st 4.261052098 4.079689762 4.672374113 4.610072906 5.183545378 2.912148696 5.048497881 hsa-miR-541-star_st 5.748402412 5.981574759 5.681589828 6.2433838 6.341800525 5.9391511 6.093392763 hsa-miR-541_st 7.639489072 7.513571252 6.779326801 7.50476707 8.232493466 8.101263457 7.944180247 hsa-miR-889_st 1.585279305 1.192503034 1.72674327 1.342641786 2.626353029 2.173169019 1.639130402 hsa-miR-875-5p_st 0.538540167 −0.011661196 0.254664596 0.251640439 0.166005299 −0.330084559 −0.70968401 hsa-miR-875-3p_st 3.163147417 3.228995953 3.385398059 2.536006385 3.571982174 2.958475739 3.339702984 hsa-miR-876-5p_st 0.594502261 −0.355354001 −0.652631534 −0.3947282 −0.3768045 0.389231182 0.975598963 hsa-miR-876-3p_st 1.357905334 1.304829813 1.800715892 0.480081216 1.643916906 1.470525506 1.595257862 hsa-miR-708_st 7.55440396 6.27260111 6.17902355 7.07138296 7.474919194 8.076530152 5.52680611 hsa-miR-708-star_st 4.373964346 4.004395469 3.584263559 3.609237171 3.887428614 3.154803137 2.345708843 hsa-miR-147b_st 4.371331162 3.722308953 4.297558583 3.476675556 4.227044978 3.738034141 4.063454842 hsa-miR-190b_st 0.279410031 0.566346156 0.088421212 −0.30435167 −0.622722797 −0.656747747 −0.385496095 hsa-miR-744_st 14.09324847 14.01963807 13.64159611 14.06808712 14.11701445 14.72129845 14.68870069 hsa-miR-744-star_st 4.45847073 3.91925144 4.745799792 4.133613416 4.936226466 4.287916966 4.59136773 hsa-miR-885-5p_st 6.965484739 6.116181877 6.00167497 5.707053667 8.165501697 7.495485076 6.150788281 hsa-miR-885-3p_st 13.2093057 12.94536002 12.2653855 12.90503522 12.66575473 13.82107055 13.49329099 hsa-miR-877_st 11.46354785 11.78968278 10.71341474 11.34637974 11.2419919 12.09846103 12.13112183 hsa-miR-877-star_st 6.90200244 5.877473647 6.850534177 6.370116962 6.836094512 7.077277729 7.217048327 hsa-miR-887_st 7.591891047 7.944165668 7.776728422 8.169008912 8.469177497 9.67007441 9.004490368 hsa-miR-665_st 12.47362751 11.88170737 11.75587876 11.66010024 12.31264344 13.07547905 12.75831744 hsa-miR-873_st 5.07787817 3.111169468 5.331925886 4.696980553 4.987182193 4.535719474 4.284712641 hsa-miR-543_st 1.805540682 3.693977546 3.307393455 3.521693424 4.092543664 3.606751033 5.09122863 hsa-miR-374b_st 4.122166731 6.194190776 7.073874094 7.739798099 6.291447371 4.270283018 6.490112402 hsa-miR-374b-star_st 2.319429497 2.237518698 2.30828274 2.011073851 1.13480868 1.271432344 2.111220352 hsa-miR-760_st 10.26386087 9.848326177 9.272927986 9.748738274 9.917078607 10.63963506 10.26605492 hsa-miR-301b_st 0.231558773 1.179847703 2.32644415 1.442854696 0.253975495 1.485389445 −0.076167876 hsa-miR-216b_st 3.224938778 4.289049403 4.286144411 4.872684375 3.461247613 3.114670074 4.23896913 hsa-miR-208b_st 2.994767965 2.966718509 2.985520328 3.146335298 2.496993364 2.61246972 2.549902803 hsa-miR-920_st 10.25743035 9.248871646 9.285180179 9.892453413 10.03615941 10.4941513 10.56397822 hsa-miR-921_st 10.72670217 10.02921398 10.17211297 10.3213818 11.05128032 11.22969542 11.05397654 hsa-miR-922_st 5.84945184 4.903436763 4.66302554 5.630938246 6.118060539 5.455006984 4.695791623 hsa-miR-924_st 2.491867963 3.064888593 3.72012057 2.751335896 3.24106063 0.944424102 1.327009845 hsa-miR-509-3-5p_st 5.704604353 5.721052794 5.213916472 4.430116846 6.389521076 6.070772308 5.921931979 hsa-miR-933_st 10.75343369 10.80442101 10.57256457 10.84547546 10.38957675 11.13175078 11.07831093 hsa-miR-934_st 3.250592731 2.835204132 4.01856052 2.354720365 3.974389046 3.808497332 3.790059051 hsa-miR-935_st 5.895680033 6.086855177 4.990401387 5.295087922 6.102459821 6.513293001 6.632482008 hsa-miR-936_st 9.816728836 9.717692655 9.225127815 9.658492954 9.865199903 10.93795777 10.81893123 hsa-miR-937_st 4.901800791 4.2046582 4.663566531 4.626611085 5.097318377 5.239588125 5.249526816 hsa-miR-938_st 4.449343942 4.031007287 3.796089877 3.811024811 4.095061408 4.673627389 3.99445415 hsa-miR-939_st 13.08393623 12.64033484 12.03966903 12.73761373 12.67205064 13.81120354 13.40577753 hsa-miR-940_st 7.802836338 7.609601727 7.821727117 7.217288858 8.522792748 8.615252218 8.327456171 hsa-miR-941_st 5.326987922 5.36717838 4.823248685 5.803131396 5.002156186 5.652529123 4.87666116 hsa-miR-942_st 1.461599964 2.015805405 2.340303697 1.60638432 2.395610188 1.401256373 1.623535994 hsa-miR-943_st 6.921388551 6.882490198 6.317256362 7.556737717 7.500512109 7.99479988 7.662945752 hsa-miR-944_st 1.385904372 1.831466572 2.126535001 1.250160667 1.713341953 1.060340904 0.418168653 hsa-miR-297_st 5.404786268 5.250557885 5.758845309 6.011798969 6.109259778 4.110748171 4.41850846 hsa-miR-1178_st 3.770267416 3.53003298 3.720843102 3.632374942 4.125609452 3.767587811 3.923467427 hsa-miR-1179_st 0.560924876 1.421815892 1.771973998 0.845535599 1.795442517 0.712885228 1.201206129 hsa-miR-1180_st 9.421351806 8.958293968 9.070844136 9.512605685 8.770750042 9.619220857 9.300269595 hsa-miR-1181_st 10.1667549 9.257919496 9.121851101 9.254555289 9.520597234 9.881645829 9.281577198 hsa-miR-1182_st 10.3205141 9.936479523 9.957470533 10.51538306 10.21864216 10.79130674 10.80056654 hsa-miR-1183_st 10.23912762 10.04171726 9.992086591 10.01354395 10.56144488 10.69011981 10.31387753 hsa-miR-1184_st 4.352302368 3.261210089 4.057078066 4.01028496 5.606830423 3.49055658 4.204705624 hsa-miR-1225-5p_st 13.3730496 13.48241304 12.82226514 13.59285649 13.39780002 14.52703283 14.17282982 hsa-miR-1225-3p_st 7.768562129 7.267447194 6.729967449 7.452748265 7.133931882 8.361052227 7.858234309 hsa-miR-1226-star_st 10.7835261 10.23493658 10.05988077 10.52565585 10.66117382 11.5311234 11.45877427 hsa-miR-1226_st 5.708953349 5.353960481 5.216292366 6.034400493 6.337818284 6.310487711 6.036169071 hsa-miR-1227_st 5.888694077 4.339955243 5.325032501 5.290556798 6.239850805 5.432499317 5.318159461 hsa-miR-1228-star_st 15.24867146 15.88335068 15.1705223 15.44423905 14.53349253 15.83167904 15.67048775 hsa-miR-1228_st 7.832604424 7.072740162 7.354228815 8.270985887 8.516011351 8.869672515 7.901490459 hsa-miR-1229_st 8.079337925 7.502404518 7.112456326 7.695573252 7.596396217 7.733745443 7.03622041 hsa-miR-1231_st 13.29546515 13.14347679 12.33068351 13.32037528 12.99435053 14.44250904 13.94326103 hsa-miR-1233_st 6.727736604 6.347853318 6.269290876 7.117139428 7.133041061 7.514199728 7.609595002 hsa-miR-1234_st 7.446542778 6.2070202 6.916643802 6.335625772 7.005074887 7.426480601 6.756259179 hsa-miR-1236_st 5.525625644 5.60077085 5.227504529 4.979727201 6.166442988 5.479618794 6.111388293 hsa-miR-1237_st 7.460143651 7.254932199 7.061362775 7.244196443 7.645789754 8.371892233 7.809468726 hsa-miR-1238_st 6.497894829 6.285586177 6.297129236 6.399280834 6.940816489 7.549483489 7.17850241 hsa-miR-1200_st 5.205927165 4.891564155 4.646726015 3.77347417 5.811080719 4.571752641 4.009752348 hsa-miR-1201_st 8.623426156 8.152476457 8.990078198 8.594043609 9.30514718 8.614697629 8.734646149 hsa-miR-1202_st 12.63747686 12.20918987 12.18939523 12.53055799 12.54326328 13.4332898 13.24944402 hsa-miR-1203_st 7.996504376 7.891752331 7.710798648 8.052820543 8.893491702 9.112853704 9.125542166 hsa-miR-663b_st 10.40662859 9.915337424 9.714881182 9.332496274 10.42737433 10.97972878 10.37230224 hsa-miR-1204_st 5.304191098 4.337908484 4.408029091 5.328821729 5.227907626 5.041018778 4.588724561 hsa-miR-1205_st 3.347458996 3.12734715 3.383574857 4.384720258 4.1870661 3.412034655 4.025876692 hsa-miR-1206_st 0.824532418 1.57223996 0.657986719 1.048979327 2.288892355 0.845189422 1.480204668 hsa-miR-1207-5p_st 14.50651391 14.6557507 14.05413455 14.61926619 14.24945829 15.40218271 15.15191042 hsa-miR-1207-3p_st 4.199337067 3.08812303 2.945595881 3.872048223 3.409220845 3.704736501 4.075857993 hsa-miR-1208_st 7.899113283 7.237238637 7.038563395 7.737828848 8.266511833 9.426295937 8.532575206 hsa-miR-548

_st 0.44686361 0.683115974 0.533342237 2.542039214 0.81914677 0.47013454 0.946564208 hsa-miR-548

_st 4.1487535 2.891615064 3.507354881 3.231510925 3.876967683 2.270491356 2.524108531 hsa-miR-1285_st 13.33430111 13.00815091 12.4887947 12.57602047 12.82914766 12.98824106 13.12505705 hsa-miR-1286_st 8.741030173 7.03040932 7.896966469 8.102601477 8.89751111 8.911098633 8.880238809 hsa-miR-1287_st 5.779484489 5.685263222 6.054232493 6.058445011 6.864395644 5.375984243 6.575840604 hsa-miR-1289_st 5.964265517 4.520060915 5.507904402 5.094374561 5.445014135 3.936551758 4.522606497 hsa-miR-1290_st 9.166036374 8.582298339 8.994859989 9.041258483 9.498916604 9.456733878 9.276381837 hsa-miR-1291_st 7.735000403 7.80364345 8.381709846 8.477314751 7.995232471 8.101655928 8.341013114 hsa-miR-548k_st 1.884914027 2.941338154 3.571631226 3.845117167 2.46458227 11.544746147 1.392997582 hsa-miR-1293_st 7.647704336 7.266265779 7.421994767 7.468327567 7.782436481 7.457729481 7.689659567 hsa-miR-1294_st 5.758069726 5.289270136 6.084272202 4.969828464 5.464682568 4.906513629 5.702112521 hsa-miR-1295_st 5.842828641 5.498166572 5.04366399 5.094810736 5.914544071 6.197025204 6.405333717 hsa-miR-1297_st 0.799085434 1.773753189 1.474034948 −0.154347372 0.046134513 1.630350888 0.903267171 hsa-miR-1299_st 6.333317555 4.846896731 5.70384078 5.737263448 6.914061367 4.31423626 3.655186293 hsa-miR-548l_st 4.009002081 3.809654632 4.133619263 4.560570934 4.507167452 3.367278831 4.353228874 hsa-miR-1302_st 1.652386045 2.051516906 1.297898644 0.740963765 1.621003123 2.030055038 1.725563732 hsa-miR-1303_st 10.75840089 10.31014521 9.987055503 9.641007274 9.872577705 10.3979247 10.28600451 hsa-miR-1304_st 6.486539798 6.575388847 6.761035036 6.266261892 7.212002475 6.581001318 7.291395156 hsa-miR-1305_st 2.23964492 2.61984501 2.256999951 2.805858484 1.802330574 1.941506129 1.95410658 hsa-miR-1243_st 2.990535773 2.92899382 2.661690595 3.618980988 2.227277173 3.012109232 3.108349089 hsa-miR-548

_st 0.794552682 0.697855346 1.159502729 0.834966099 0.303356803 0.943249207 0.483959665 hsa-miR-1244_st 8.071397053 8.149003012 9.050160098 8.981644705 8.914975273 8.995573895 8.118169322 hsa-miR-1245_st 2.828472282 3.326473254 2.79538873 3.004523028 3.278243796 3.603673474 3.319459402 hsa-miR-1246_st 13.02643745 13.26400421 13.13752855 13.2191444 12.78620332 12.85934439 13.07470331 hsa-miR-1247_st 6.597744835 5.663792009 6.239961809 5.746350172 5.952444283 7.664384714 6.013757726 hsa-miR-1248_st 9.313928653 9.664122204 9.971933553 10.62740335 10.32738997 9.725973627 10.1256414 hsa-miR-1249_st 4.971083895 4.352905935 4.684337858 4.88883234 5.657470183 5.147616145 4.619079982 hsa-miR-1250_st 8.67918742 7.737641888 8.1873687 8.225551512 9.30282666 8.307473653 9.080009271 hsa-miR-1251_st 3.718263732 4.621119252 5.715141443 6.979903888 3.941686766 3.336985741 5.182304921 hsa-miR-1253_st 4.269887958 3.806724699 4.531717736 4.619131876 4.432304947 4.186553905 4.256422889 hsa-miR-1254_st 11.23587328 10.50683709 10.24874425 10.60287101 11.0219449 11.98363338 11.23120595 hsa-miR-1255a_st 5.365524479 4.672347076 5.159273303 5.569252323 5.555665295 4.577440684 4.625339589 hsa-miR-1256_st 3.199576116 3.17428179 4.70136052 3.983161789 4.342417656 2.008958653 1.531976485 hsa-miR-1257_st 3.54633271 3.653829094 4.132731258 3.427909302 4.352579394 3.552421552 4.346040535 hsa-miR-1258_st 3.946593477 4.098563446 3.1897803 3.183865086 5.808573884 4.041570964 4.564685123 hsa-miR-1259_st 1.608780695 2.565086439 2.366787991 2.84370509 1.985231452 1.401969999 1.202509585 hsa-miR-1260_st 10.40275691 11.08287471 10.50666654 10.51230143 9.589388795 10.0806496 10.3308085 hsa-miR-548g_st 0.581732821 1.380152389 0.561799773 −0.018105876 −0.7912175 0.437944333 0.454037462 hsa-miR-1261_st 7.170204544 6.750779416 6.86075105 7.417506659 8.046426671 8.217420936 8.40684468 hsa-miR-1262_st 1.006115209 2.511087897 2.432251778 1.729033225 2.632286527 1.000295989 2.490891676 hsa-miR-1263_st 3.671072331 2.43258445 3.041120001 2.828042706 3.441202234 3.223552053 3.789065134 hsa-miR-548n_st 1.492210457 1.334915506 2.630167506 1.328713453 1.392540297 1.69160298 0.139778105 hsa-miR-548m_st 2.220539483 2.403331786 2.914787083 3.621147345 2.90030524 1.076870008 1.223740093 hsa-miR-1265_st 4.879670511 4.960251428 5.128342147 4.607699911 5.366557894 3.589632418 4.12516532 hsa-miR-548o_st 2.550235755 1.809516108 1.036974417 1.40203856 2.401846175 0.246171242 0.886316106 hsa-miR-1266_st 8.092477746 7.619307137 7.834546953 8.404740079 8.485189511 9.388296014 8.62435427 hsa-miR-1267_st 4.265216641 3.343352841 3.658090892 2.785731758 3.235208875 3.853123412 3.680739074 hsa-miR-1268_st 14.94917819 15.2219134 14.44293943 14.86718959 14.36722631 15.67421174 15.29265589 hsa-miR-1269_st 4.428153478 4.870550306 4.718878363 4.029209915 5.309937431 5.059762216 5.058944544 hsa-miR-1270_st 5.740805301 6.199652161 5.532897024 6.79685106 6.373376601 6.279767358 6.051949953 hsa-miR-1272_st 3.467358832 3.223719021 3.892802021 2.069955945 4.318773544 2.835849596 3.27362261 hsa-miR-1273_st 11.03257812 11.09945265 10.60483481 10.45707144 11.18984734 10.30967973 10.95998332 hsa-miR-1274a_st 10.63013359 11.05078298 10.67598948 10.88263655 10.19071206 11.49131218 11.00006558 hsa-miR-548h_st 4.074263999 3.256563591 4.375861485 2.998969925 2.35328987 2.024109919 2.359912074 hsa-miR-1275_st 13.81351143 13.3993736 13.29753808 13.55323555 13.74736678 14.28979841 14.19099142 hsa-miR-1276_st 5.864459249 5.698057284 5.304785316 4.532261763 6.449252439 6.007186759 6.279568717 hsa-miR-302

_st 2.82401543 2.097613458 3.111637824 2.791077509 4.166208469 1.086448182 2.500091196 hsa-miR-302

_st 0.966171712 1.875028865 1.44963233 1.514685554 0.603706852 1.490830469 0.82029764 hsa-miR-1277_st 1.457847327 2.017360794 2.266847891 1.952479553 1.510541575 1.404568286 1.665504545 hsa-miR-548p_st 1.44039033 1.678206956 0.866109068 1.429777948 0.656395673 2.134872838 1.145599335 hsa-miR-548i_st 5.489830277 4.41608705 5.403790274 4.904343926 5.327893788 3.220426363 3.484818987 hsa-miR-1278_st 2.959075373 3.665362256 3.778179236 4.424875182 2.49945755 2.888658728 2.843858005 hsa-miR-1279_st 3.011420483 2.980631994 4.86563415 3.857222067 4.241671924 1.414593802 1.881452527 hsa-miR-1274b_st 13.8953473 14.0830953 14.24051857 14.12473728 13.24421404 14.25372017 13.91959034 hsa-miR-1281_st 9.066540175 8.396412021 8.205188893 8.345758838 9.021066245 9.0653027 9.296346678 hsa-miR-1282_st 4.632387273 3.804729646 4.832931552 4.50046572 5.152020072 2.786353282 3.666140393 hsa-miR-1284_st 4.439892501 3.745898523 3.748503642 4.156305087 4.868053547 3.852632084 3.327636599 hsa-miR-1288_st 4.250362802 4.732828893 3.712746617 4.773842697 4.055263386 3.981287333 4.47175624 hsa-miR-1292_st 12.0799599 11.80351024 11.60304513 11.748145 12.11399642 13.15674427 12.70349083 hsa-miR-1252_st 1.631417262 1.436528832 1.488617827 2.070940555 1.098821961 1.988367223 2.057676929 hsa-miR-1255b_st 8.882065385 8.397153807 8.49154682 7.498980109 8.60803343 8.024935844 7.708445133 hsa-miR-1280_st 14.80588843 15.40611039 14.83091836 14.90898491 13.71965271 14.9361986 14.74120197 hsa-miR-1308_st 14.93604122 15.42784598 14.63544424 14.84622385 14.37932811 15.56819828 15.27865834 hsa-miR-664-star_st 10.08824902 9.116293351 10.23776913 9.220519912 9.826454758 9.259838538 9.92416625 hsa-miR-664_st 5.436691335 4.746876098 5.091850407 5.459585746 5.702010646 5.665704983 5.944617488 hsa-miR-1306_st 5.952731712 6.308482501 6.432773142 6.542987273 7.507046709 6.872932356 6.765366092 hsa-miR-1307_st 13.30535552 13.38702044 12.50833195 13.24395914 12.99216439 14.28752436 13.91560532 hsa-miR-513b_st 9.667055463 9.613555404 10.70872942 10.6330214 10.86092251 10.97497465 11.21328094 hsa-miR-513c_st 8.297081404 7.536278229 8.22461603 8.104812489 9.251092175 9.092323849 9.296934924 hsa-miR-1321_st 6.901093894 6.771097702 7.106131501 6.930425872 7.640096684 6.908974632 7.761179472 hsa-miR-1322_st 3.914019806 3.448498164 3.470609506 3.540354824 4.24332251 3.692631473 3.362141243 hsa-miR-720_st 14.98882581 15.37395921 15.09005902 15.01040651 13.91270298 15.43901846 14.54973903 hsa-miR-1197_st 2.01805118 2.623844912 2.347619833 1.961806181 1.783893079 0.888667431 1.842047585 hsa-miR-1324_st 1.607923354 1.947692293 2.354792636 1.112990681 1.643093598 1.455884152 2.213429778 hsa-miR-1469_st 15.22828253 15.86860022 15.16955717 15.44886069 14.53291464 15.83157801 15.68485596 hsa-miR-1470_st 5.585456142 4.922763035 4.388830314 5.365528782 5.588502574 6.274821586 5.155740393 hsa-miR-1471_st 10.88796331 10.12701766 9.854973102 9.905605182 11.03480385 11.21767568 11.5380136 hsa-miR-1537_st 1.595276342 2.037066372 1.71436831 0.814158105 0.588147159 0.673061764 1.179419767 hsa-miR-1538_st 7.268420994 7.615397332 7.108693022 6.999986308 8.058420376 8.386394029 7.605800874 hsa-miR-1539_st 5.916922553 5.990814163 5.679635753 5.834709318 6.014130129 6.241943669 6.123561058 hsa-miR-103-as_st 2.752161768 2.291901794 2.139348341 2.810900456 3.813760476 1.814992319 1.621332063 hsa-miR-320d_st 9.406603759 9.800391485 10.54924815 10.0589528 8.816054245 9.250202494 9.416120982 hsa-miR-1825_st 6.190463203 6.018731663 6.132994182 6.524292016 7.055299397 7.062129851 6.442960872 hsa-miR-1826_st 15.50587766 16.26207727 15.16633314 15.49885302 14.5339472 15.83083235 15.71017665 hsa-miR-1827_st 3.843786348 5.639758447 6.578011481 6.532564432 6.018656798 4.15497128 5.465714373 hsa-miR-1908_st 15.36672371 16.12617118 15.30266162 15.50010419 14.53389508 15.83102386 15.71031479 hsa-miR-1909-star_st 8.862390484 8.156753439 7.975106092 8.265969146 8.537712758 8.99077341 9.129826616 hsa-miR-1909_st 14.40397812 14.25268364 13.81198373 14.16695026 14.16764201 14.91311077 14.73535624 hsa-miR-1910_st 10.20115232 8.660954391 8.936665359 9.215033298 9.169677685 10.00585819 9.738615629 hsa-miR-1911_st 3.470392012 3.423764108 3.422255662 3.058182882 4.74411524 3.696934131 3.278108035 hsa-miR-1911-star_st 4.827063796 5.008613494 4.891899693 6.00476189 4.507083219 4.636583617 4.818668204 hsa-miR-1912_st 3.589225811 3.815706193 4.576248829 4.089330481 3.877241564 3.922984142 3.667678247 hsa-miR-1913_st 8.075766292 7.562275017 7.198735568 7.278278815 7.959859314 8.76903596 8.517550318 hsa-miR-1914_st 7.061996312 6.279432211 7.077486342 6.732634269 7.131241378 6.77243328 6.321844635 hsa-miR-1914-star_st 12.36812436 12.08851744 11.79509276 12.25285398 11.92912213 12.90122417 13.03353095 hsa-miR-1915-star_st 7.824000995 7.452228103 7.577943591 7.17808095 8.099955499 7.066602395 6.8620742 hsa-miR-1915_st 15.38161198 16.11295899 15.26682994 15.4991243 14.53352223 15.83184979 15.70979606 hsa-miR-1972_st 13.82967707 13.47030929 13.10664147 12.63883731 13.18332823 12.93487135 12.48483901 hsa-miR-1973_st 13.97074855 14.67243449 14.31288182 14.27979701 14.5350626 15.20462859 15.24363118 hsa-miR-1975_st 15.4931759 16.02278069 15.30512044 15.49540235 14.52992145 15.77362369 15.59277397 hsa-miR-1976_st 7.931872509 7.110831669 7.286069909 6.903276481 7.842389157 7.735508039 7.344587623 hsa-miR-1979_st 15.06256507 15.30524163 14.40346944 15.23733244 14.17434994 14.86590562 15.11579688 hsa-miR-2052_st −0.18128035 1.307712753 0.673732632 −0.066622305 0.171310892 1.579574611 0.24651085 hsa-miR-2053_st 0.306674829 2.256648569 1.590859985 2.698192286 2.25588578 0.838845201 1.090029472 hsa-miR-2054_st −0.377192814 0.815436126 −0.802650027 −0.458920601 −0.878376175 0.225891486 −0.685179269 hsa-miR-2110_st 10.28769483 10.03467203 9.829702772 10.33710626 10.16696434 10.95661784 11.15048165 hsa-miR-2114_st 2.46894214 2.04622731 2.733136858 2.646066249 3.59475051 13.519096866 2.357837486 hsa-miR-2114-star_st 6.413481302 5.630244799 5.650849443 4.730436828 7.961763628 7.032048356 6.455600705 hsa-miR-2115_st 1.238749796 2.381950617 2.03651834 2.34454499 2.111704986 1.485596539 1.504416397 hsa-miR-2115-star_st 7.920738142 7.683484511 6.421142555 7.269441523 9.250687785 7.824862466 7.504259856 hsa-miR-2116_st 6.307916912 4.830066678 5.286780453 4.386678636 5.800974647 6.236758362 5.611345917 hsa-miR-2116-star_st 4.840520647 4.953969915 4.325339187 4.861397804 5.449105487 3.901983075 4.071903599 hsa-miR-2117_st 1.705858466 1.685713595 1.739933999 0.79367315 3.620336274 2.388775658 1.025898666 hsa-miR-548q_st 7.433378006 7.363851764 6.702843358 6.471464736 7.876758315 7.789902386 6.320124994 hsa-miR-2276_st 9.776282102 9.289609553 9.254087226 9.477493969 9.61247373 10.38477688 10.13088508 hsa-miR-2277_st 8.206473651 8.144681781 7.403499965 8.058947607 8.548308566 8.971237002 8.850862671 hsa-miR-2278_st 5.254669392 5.091371732 5.024829664 5.362573062 5.299503812 5.590651707 4.866894469 hsa-miR-711_st 10.908872 10.22535162 10.66560957 11.02474765 11.35633374 11.88371834 11.88903123 hsa-miR-718_st 7.772221731 6.40575076 6.954535025 7.000859731 7.523553932 8.494278162 7.624311889 hsa-miR-2861_st 15.36791735 16.16258847 15.29234121 15.49875229 14.53406393 15.83133194 15.71056029 hsa-miR-2909_st 2.545817726 3.09793504 3.319480833 3.137747413 3.322000679 2.935254682 2.458677095 hsa-miR-3115_st 1.413278401 1.936272822 2.243885261 0.285815826 2.467287976 1.701047637 2.16057981 hsa-miR-3116_st 5.677384586 5.726605124 5.741660793 5.769077555 6.433749108 6.699159002 6.04880894 hsa-miR-3117_st 2.485330186 2.789571714 3.015089228 1.912330942 3.109854617 2.5515233 2.91833621 hsa-miR-3118_st 1.572829689 2.55875517 3.063745626 2.331618144 1.721606823 1.509211296 2.203582079 hsa-miR-3119_st 1.41954092 1.234176916 0.910753926 1.876234397 0.574332187 1.252412629 −0.276649999 hsa-miR-3120_st 5.751863007 5.248937981 5.334837406 5.667002805 5.993567011 5.610385696 6.04066769 hsa-miR-3121_st 6.382228955 6.334919499 6.253458159 6.166158122 7.149443668 6.829141554 7.384561764 hsa-miR-3122_st 10.56094112 10.24325543 9.814864983 10.78809293 10.7331607 11.61415433 11.34042164 hsa-miR-3123_st 0.630043246 0.062765885 −0.372385274 0.634308373 −0.839670623 −0.424664146 −0.352527953 hsa-miR-3124_st 11.52662958 11.10808422 10.38498517 10.95239681 11.16450362 11.83724151 11.85885934 hsa-miR-548s_st 1.865987636 1.854746135 1.765217405 1.59232995 1.626525126 1.452279379 1.549474029 hsa-miR-3125_st 6.274721597 6.604860727 6.520971426 7.370989873 7.180788497 7.145909731 6.839644617 hsa-miR-3126-5p_st 11.3355542 10.58798571 11.03759911 11.21402991 11.60028585 12.07346528 12.2521444 hsa-miR-3126-3p_st 5.012886706 3.939803177 4.275618002 4.765615023 4.424292168 4.292269032 4.834780084 hsa-miR-3127_st 8.917610582 8.606263832 8.460299648 9.048219178 8.965362233 9.304704128 9.484717375 hsa-miR-3128_st 2.680030316 2.758055721 2.57417768 1.845215941 3.155247851 2.465893166 2.360842349 hsa-miR-3129_st 3.615105572 3.132488677 3.510828592 3.561733342 4.149439046 3.24320416 3.302787248 hsa-miR-3130-5p_st 6.449619782 5.988501074 5.98227786 6.433692886 7.236972148 6.572643261 7.009255958 hsa-miR-3130-3p_st 7.461910758 6.98517947 6.35618028 7.320098766 7.480741766 8.155804133 7.545450659 hsa-miR-3131_st 11.7162425 10.9505356 11.16040852 11.03121604 11.65406796 12.19364465 12.13119762 hsa-miR-3132_st 7.929125545 8.126921693 8.282559672 8.790891277 8.478483894 9.192818924 9.14546933 hsa-miR-3133_st 2.28574953 2.583856224 2.931582644 2.988642277 2.492678904 2.110154416 3.388543432 hsa-miR-378b_st 8.190594212 8.727377863 8.146824383 8.464604673 8.847551957 8.96409278 8.860412442 hsa-miR-3134_st 1.949163642 2.48171606 1.336308084 1.293095066 2.412839883 0.324418566 0.931937896 hsa-miR-3135_st 6.666898454 5.60813541 5.832960002 5.770409101 6.324432599 6.577521852 6.051698139 hsa-miR-466_st 6.256922382 5.752867775 5.39606828 5.390063769 6.992065298 4.706598296 5.476033225 hsa-miR-3136_st 5.964058112 5.613858668 5.30212754 5.617211545 6.692776019 5.987710392 6.685015217 hsa-miR-544b_st 1.961536427 2.289792259 2.57099512 2.443863245 3.086661191 1.793993462 2.165405534 hsa-miR-3137_st 10.20625676 9.918962387 9.526890276 10.40964899 10.16166641 11.23855577 10.78316545 hsa-miR-3138_st 10.32080424 9.488447865 10.19384462 10.34025937 10.16832272 11.26928833 11.31472514 hsa-miR-3139_st 2.439885547 2.414646654 2.226334709 2.006461653 2.801687578 2.411887039 1.985186232 hsa-miR-3140_st 4.834043967 4.639718588 3.740248916 3.572295201 4.688831015 4.665224443 4.624949544 hsa-miR-548t_st 1.747013982 2.76990208 2.31734993 3.2316209 2.575190622 2.292165516 2.549902427 hsa-miR-3141_st 14.56932438 14.7291538 14.14800755 14.49120012 14.16930883 15.37479435 15.09188915 hsa-miR-3142_st 1.695312345 1.469072187 1.059172518 1.166858182 1.26804272 1.643860314 1.731127528 hsa-miR-3143_st 0.07966077 1.11802397 0.638403259 −0.138626943 1.362845873 −0.05359338 −0.106609177 hsa-miR-548u_st 1.651926922 1.59539641 2.421179281 2.367234176 2.925022775 1.637060588 0.615487311 hsa-miR-3144-5p_st 4.882875369 4.656077992 4.644484301 5.118924567 5.672945435 4.968066575 4.916071726 hsa-miR-3144-3p_st 2.738952499 3.000865689 2.533654533 2.747709897 3.17254822 2.617009905 3.990977388 hsa-miR-3145_st 0.055473026 0.67763553 0.188116774 0.049766145 0.779210549 0.889256046 0.286714613 hsa-miR-1273c_st 9.90472503 9.43537457 9.795252743 9.970191241 10.09048653 10.17754341 10.42008806 hsa-miR-3146_st 4.20240964 3.705415929 3.587421991 2.35180705 3.803379498 3.158513046 3.061553252 hsa-miR-3147_st 11.13768833 10.62937171 10.60001109 10.72587768 10.82724064 11.37846378 11.27473106 hsa-miR-548v_st 2.442368027 2.988389393 3.707428018 3.527207974 3.641251783 1.321764709 3.457068611 hsa-miR-3148_st 5.198093012 4.42720859 3.875386632 4.762473421 5.227989568 5.008262754 4.108404148 hsa-miR-3149_st 2.809794529 1.940989406 4.057900151 4.149343158 3.475687514 2.274564816 2.093383297 hsa-miR-3150_st 8.802378504 8.434243262 8.28177163 9.130804562 9.103377404 9.623332485 9.4401968 hsa-miR-3151_st 10.79586281 10.52252658 10.33300954 10.64251968 10.48394041 11.26211321 11.15687361 hsa-miR-3152_st 6.477694999 6.390645607 6.373901124 6.299514522 6.759208573 6.989595331 6.521175326 hsa-miR-3153_st 9.120933155 8.874850694 8.459952297 8.817173222 9.000091796 9.120393189 9.529892758 hsa-miR-3074_st 5.119070445 4.140910206 4.288173995 4.125670093 4.087623133 3.979735238 3.744019594 hsa-miR-3154_st 11.32335921 10.71790071 10.63956328 10.89604519 10.95482735 11.79220463 11.57509418 hsa-miR-3155_st 6.530807823 6.317042053 6.53503041 6.468660911 7.316242338 7.337678303 7.002524519 hsa-miR-3156_st 10.05317266 9.909538439 9.959304197 10.29802435 9.773439985 10.49110833 10.28648875 hsa-miR-3157_st 5.32255978 4.829436489 4.885936538 4.87600744 5.357329584 5.559204422 5.501835857 hsa-miR-3158_st 3.695240213 4.229479521 4.187219188 3.880908243 5.194370948 4.414033841 4.002877263 hsa-miR-3159_st 3.34413761 3.478509635 4.152360558 3.235383658 3.686109282 4.39526905 3.740007101 hsa-miR-3160_st 5.055148 5.314675646 5.097657276 5.229171559 5.68510048 5.851492984 5.282940917 hsa-miR-3161_st 6.47670426 6.347623956 5.888156391 5.97226241 7.539654786 7.092479234 7.257155693 hsa-miR-3162_st 13.11527046 12.89974007 12.44563495 13.26225432 12.99085333 14.04745034 13.7503546 hsa-miR-3163_st 7.13001139 7.294146427 7.073398267 8.103671973 7.949557354 8.076270978 7.208437079 hsa-miR-3164_st 6.12066392 6.180401533 5.689981304 6.070208195 6.706305381 6.374133679 6.537639188 hsa-miR-3165_st 5.93187898 5.980026721 6.205619096 7.173720586 6.626518007 7.03737729 7.412012516 hsa-miR-3166_st 4.019428406 4.33335431 3.824869502 4.008568204 3.861944297 4.529972953 3.728886515 hsa-miR-1260b_st 13.80865982 14.5533218 13.73049611 14.34257205 12.84707752 13.69539862 13.86175647 hsa-miR-3167_st 1.130398286 2.57433395 0.204145248 0.263799113 0.809023023 1.284475072 1.753026482 hsa-miR-3168_st 1.773244888 2.531243657 2.264887253 0.912632519 2.73540565 1.682399797 2.007728212 hsa-miR-3169_st 3.932399473 3.367649915 3.450176152 4.043607136 4.034873855 3.564478119 4.587484528 hsa-miR-3170_st 5.773286425 5.530039056 5.61107952 5.779599049 6.390023354 6.455677044 5.868933465 hsa-miR-3171_st 2.080327009 2.546224501 2.6166347 1.916591221 0.778886534 1.955187015 0.646801465 hsa-miR-3172_st 14.87003476 15.64546516 14.72631397 14.87603789 14.30953143 14.75071956 14.94756248 hsa-miR-3173_st 8.473346789 8.170716112 8.596609895 8.858337274 9.017505288 9.4327819 9.38343232 hsa-miR-1193_st 9.370720477 9.256452167 9.600637791 9.835350028 9.773822736 10.28727306 10.3316528 hsa-miR-323b-5p_st 8.046981225 7.1640292 6.925509259 7.016500356 7.600071672 7.463741081 7.300280224 hsa-miR-323b-3p_st 2.782520587 3.074113806 2.753225566 3.25297221 2.655059942 2.330341776 3.096981124 hsa-miR-3174_st 6.390068347 5.710256118 6.258946335 6.526312048 7.336500546 6.409653183 5.944397141 hsa-miR-3175_st 12.86018919 12.68191769 12.71895312 12.63019441 12.67627018 12.94779946 13.20819847 hsa-miR-3176_st 10.71752041 10.72694394 10.1458847 10.44005268 10.60051773 11.19572837 10.76012955 hsa-miR-3177_st 11.22322405 10.67969762 10.49638801 11.03673274 11.02697344 12.0487339 11.86200914 hsa-miR-3178_st 14.84047163 15.31685611 14.92355508 15.04914233 14.5322918 15.73859723 15.51317343 hsa-miR-3179_st 3.108401656 2.560647565 3.108999627 2.18932308 4.97078861 3.054140159 2.745499944 hsa-miR-3180-5p_st 7.763786493 6.662718492 6.795519097 7.267921181 7.147126368 7.942463868 7.372625186 hsa-miR-3180-3p_st 14.23895306 14.09768183 13.39441555 13.90923056 13.8212402 14.86180169 14.56874938 hsa-miR-548w_st 7.089096798 6.028725816 7.075623596 6.349187431 7.048076456 4.761813269 4.865359559 hsa-miR-3181_st 8.39148411 7.792795003 7.091914496 7.128721022 7.607516563 9.453165835 8.45296633 hsa-miR-3182_st 2.36896044 2.959051607 4.134028873 3.165686076 2.933380323 1.733975959 2.958692548 hsa-miR-3183_st 3.290039111 3.738264903 2.888159021 4.231102076 4.042987908 4.480911075 3.744895152 hsa-miR-3184_st 9.228275122 8.813382265 9.020348021 8.764044648 9.386267473 9.783788117 9.305150581 hsa-miR-3185_st 14.57875923 14.73526052 13.55456919 14.45158868 14.1436258 15.33260865 15.03765902 hsa-miR-3065-5p_st 1.912887773 4.445529232 5.287276829 4.293033284 3.376885305 2.685381418 4.110415907 hsa-miR-3065-3p_st 4.413279466 4.965085074 4.601754955 3.838988301 4.285595821 4.088492137 5.215985707 hsa-miR-3186-5p_st 4.460190355 4.286739391 4.3378327 3.324214963 5.275866057 3.900751303 3.658559316 hsa-miR-3186-3p_st 8.539669572 8.12784033 8.067931706 8.285220828 8.504953111 8.891588008 8.713370275 hsa-miR-3187_st 12.17035214 11.6282248 11.29841344 11.80226783 12.54423143 12.85471945 12.55441583 hsa-miR-3188_st 12.48690106 12.20877012 11.41013801 12.31535728 12.11279358 13.51555744 13.13152604 hsa-miR-3189_st 6.886016536 6.809562929 6.436718463 6.769883632 7.175720634 7.892821596 7.148431141 hsa-miR-320

_st 9.263855681 9.476331059 10.0868345 9.786200932 8.620602766 9.123092563 9.203596286 hsa-miR-3190-5p_st 9.141092614 9.016443616 9.159709204 9.56645797 9.802986052 10.45564545 10.16608014 hsa-miR-3190-3p_st 9.462605136 9.334991533 9.358244185 9.750910969 9.656566043 10.6908063 10.35295762 hsa-miR-3191_st 11.52255255 10.61495389 10.99027282 11.34740057 11.43982861 11.82071177 11.94331995 hsa-miR-3192_st 8.649371986 8.126272303 7.991371006 8.496685235 8.954839124 8.961641632 9.006631762 hsa-miR-3193_st 5.679530464 5.506540092 6.127073005 5.804503529 6.14028567 6.071393175 6.45871691 hsa-miR-3194_st 10.15681871 9.540791858 9.579243042 9.874483237 10.37106851 10.79481532 10.78915705 hsa-miR-3195_st 12.70965904 12.16703876 11.54220032 11.79419203 12.21212559 13.02887324 12.86349721 hsa-miR-3196_st 15.53905776 16.28170265 15.31135483 15.49927968 14.53181774 15.83137173 15.71070786 hsa-miR-548x_st 0.639325962 0.901282077 0.79929523 0.628391667 0.129471688 0.204108023 −0.19213261 hsa-miR-3197_st 14.18362318 14.65065527 14.4340179 14.69235717 14.5005803 15.35014127 15.19538457 hsa-miR-3198_st 8.909009189 8.608614477 8.625271539 9.145051516 9.16587878 10.11049917 9.589649085 hsa-miR-3199_st 5.263134701 4.38074435 4.364344803 4.320157187 5.704452414 4.358384096 5.416730415 hsa-miR-3200_st 3.161033776 4.025575105 4.692256084 4.673284515 3.624632287 2.06738048 4.135898179 hsa-miR-3201_st 3.541248819 3.805494447 3.063865135 3.38511774 2.768449591 3.319162743 3.889435684 hsa-miR-514b-5p_st 9.434179442 9.153702323 9.217463565 9.578007798 9.967058538 10.06856653 9.776149666 hsa-miR-514b-3p_st 1.976316805 1.989856394 1.426155483 1.435348716 1.742027815 2.411813925 1.206783685 hsa-miR-3202_st 7.073189993 7.112850402 7.443557073 7.568616773 7.898026042 7.942985935 7.861975679 hsa-miR-1273d_st 12.07836091 11.66695293 11.49633373 11.18967281 11.12850142 11.02290196 11.00169041 hsa-miR-4295_st 2.219466857 2.139421816 2.805674139 1.254592781 3.023111323 1.315861446 2.068824506 hsa-miR-4296_st 7.48491885 6.90760476 6.108965523 5.35510301 7.7512865 6.754467285 6.81347504 hsa-miR-4297_st 5.670322987 4.98980718 5.650017627 5.439531413 6.497076537 4.966878864 6.07761014 hsa-miR-378c_st 8.075101699 8.033645257 8.808352625 9.100213596 8.746313946 9.122998121 8.330768291 hsa-miR-4293_st 4.37172883 4.109828109 4.086080757 4.307026963 4.275520746 4.547283907 5.392728295 hsa-miR-4294_st 7.481153293 6.91149177 7.558529339 7.244048976 7.621170716 7.799023059 7.655182395 hsa-miR-4301_st 2.818798622 2.60645247 2.78892964 2.345675164 0.522742731 1.074041925 2.128799987 hsa-miR-4299_st 12.05659727 12.09834933 12.66421984 12.65788685 13.0334779 13.51867114 13.3246008 hsa-miR-4298_st 12.58812349 12.53573197 12.35668678 12.78107448 12.6480775 13.4060123 13.12797181 hsa-miR-4300_st 7.161391413 6.95567403 6.037551085 6.57196457 7.810743774 8.064461286 7.755579197 hsa-miR-4304_st 6.089357109 5.701927756 6.059980055 5.644317816 6.088406496 6.340026321 5.420582731 hsa-miR-4302_st 5.963622133 5.515523129 4.766567559 4.495000852 5.706249065 5.494622234 5.111962397 hsa-miR-4303_st 6.111169503 5.440604988 6.001063779 6.000298409 6.590324392 6.364861429 6.62831735 hsa-miR-4305_st 4.202856017 3.837546276 2.961465968 3.677286193 4.46110794 2.332976389 3.304915114 hsa-miR-4306_st 9.282911039 8.940876277 10.03554276 9.726933704 9.791884762 9.166164656 9.280134261 hsa-miR-4309_st 3.351716667 3.915182995 3.119480508 4.081796029 3.06432113 3.384715826 3.568271745 hsa-miR-4307_st 3.446013852 2.705881622 3.218497829 2.848625951 2.505498813 2.347619972 2.40996454 hsa-miR-4308_st 1.81160017 0.900775218 3.95836533 2.569646273 4.736076769 1.698102701 −0.050242221 hsa-miR-4310_st 3.61591216 3.406759551 3.534973865 3.200110899 3.986172412 3.428936167 4.68705003 hsa-miR-4311_st 5.268279971 4.506457653 4.783057011 4.762950871 5.083185755 4.195793025 4.722818483 hsa-miR-4312_st 6.158806152 5.562110779 5.674927687 6.046393989 7.083683585 6.618348836 7.155204626 hsa-miR-4313_st 5.774298155 5.744425037 5.070700374 4.860930492 5.545820369 5.632840694 5.02406122 hsa-miR-4315_st 3.832077164 3.376791457 3.613141601 1.315425646 3.261485823 3.542305385 2.119148903 hsa-miR-4316_st 7.011870998 7.137774779 6.595361143 6.953089155 7.282161377 7.580968943 7.186343162 hsa-miR-4314_st 8.424165966 7.951440979 7.940952393 8.547408149 8.873631299 8.672230049 8.463766145 hsa-miR-4318_st 3.260461495 2.920004471 3.362836281 3.771869026 2.434533697 2.509148747 2.930914093 hsa-miR-4319_st 3.773306123 2.90423951 3.299110309 1.870652131 4.625432568 3.222991464 3.862592832 hsa-miR-4320_st 2.564673468 2.997114923 2.947977616 2.33115349 1.344200071 2.176769863 2.770817374 hsa-miR-4317_st 8.923029572 8.87079085 8.813434135 9.16409292 8.975067067 9.202460064 9.686813667 hsa-miR-4322_st 12.15044048 11.75827297 11.21239516 11.73918168 11.84706877 12.9039712 12.4326584 hsa-miR-4321_st 10.06733764 8.570222806 8.774261434 9.654911362 9.33442321 10.43809905 10.081932 hsa-miR-4323_st 5.611698061 5.129023136 5.323666992 4.859042311 6.276210215 6.025180546 5.272196406 hsa-miR-4324_st 7.197692236 7.264416684 7.763840103 8.697732169 6.289309834 6.414060472 7.480767725 hsa-miR-4256_st 3.778191253 3.484732192 3.433191495 3.729854543 3.666361754 3.980854038 3.570092295 hsa-miR-4257_st 11.61630969 11.22624102 11.173811 11.66483233 11.95937863 12.43951835 12.42531151 hsa-miR-4258_st 7.05684659 6.758624713 6.706779888 7.110311519 7.366696705 7.974619474 7.564725439 hsa-miR-4259_st 10.31612181 10.0972969 10.04688495 10.41011934 10.52843707 11.28390392 11.20459012 hsa-miR-4260_st 9.934255683 9.6974814 9.497927139 10.05243426 10.38740469 11.26290711 10.84894645 hsa-miR-4253_st 10.94325295 10.53486344 9.382332208 10.77654639 10.30130979 11.87002694 11.0720852 hsa-miR-4251_st 5.959184496 5.145460752 5.641174335 5.082869293 5.690303682 6.495687146 6.103203421 hsa-miR-4254_st 5.263434455 5.406242379 5.353957445 4.276094418 5.336639541 5.398111164 5.747805442 hsa-miR-4255_st 2.779201757 2.682653308 2.353279478 2.440565985 2.67720195 2.709991132 2.931546048 hsa-miR-4252_st 4.954896134 4.36412946 4.608268232 4.710064558 4.726923841 4.929985145 4.89251963 hsa-miR-4325_st 2.581088587 3.15643584 3.657105249 3.163869184 2.898559949 2.712018596 2.99310898 hsa-miR-4326_st 4.519922416 4.215471803 5.15894637 5.198679542 5.259475575 5.17004873 4.568383986 hsa-miR-4327_st 11.4785337 11.13289466 10.88493226 11.54716271 11.31150484 12.35103234 12.07234527 hsa-miR-4261_st 8.27941676 8.252080117 8.454613797 8.342882591 8.541538972 8.532189392 8.424020402 hsa-miR-4265_st 7.230204994 6.751223585 6.995385817 6.926814437 8.008516636 8.130377128 7.075633329 hsa-miR-4266_st 5.737945221 5.205356228 4.950480238 5.150353387 5.801653653 6.391334331 5.876488304 hsa-miR-4267_st 5.414966575 5.237375149 5.356802768 5.282128524 5.058805771 6.215340561 5.979414082 hsa-miR-4262_st 1.11352019 2.010583297 1.404089399 3.361448698 0.933191434 0.499419015 1.411694108 hsa-miR-2355_st 2.451564924 3.005322707 1.752137736 2.375507986 1.881761575 2.316176853 2.349611677 hsa-miR-4268_st 3.878892166 3.383421912 3.30870814 4.409794591 3.836592396 3.66462124 3.651450901 hsa-miR-4269_st 7.647573844 7.361324193 7.350295586 7.474638443 7.591727581 8.243208918 7.295971325 hsa-miR-4263_st 2.897367252 2.854330203 3.198309191 2.916433852 2.54952666 2.1106731 1.946336618 hsa-miR-4264_st 2.360459661 2.555651444 1.662711397 2.635492247 2.901200782 2.398923091 2.194039083 hsa-miR-4270_st 14.76903588 14.8977843 14.28603806 14.86834796 14.33858693 15.71612339 15.25085457 hsa-miR-4271_st 11.26552869 10.69345375 10.91885546 11.40453569 11.09625185 12.0996921 11.71406075 hsa-miR-4272_st 2.029967476 2.063486562 1.119464816 0.479548059 −0.125264244 0.779872036 1.197038805 hsa-miR-4273_st 0.919750283 1.242349958 1.768366915 0.674529963 2.44533478 0.42295701 0.539418548 hsa-miR-4276_st 1.451202622 1.26008887 1.992381944 1.240573395 0.5047776 1.874571633 0.270794869 hsa-miR-4275_st 2.637497712 1.930413539 1.845608378 2.199785703 2.761088376 0.344462935 1.921899108 hsa-miR-4274_st 5.401284804 5.492092522 4.949995338 4.949286304 5.627987532 5.771016274 5.558610949 hsa-miR-4281_st 14.95015845 15.38928323 14.8154776 15.32409242 14.53295182 15.83054893 15.5561999 hsa-miR-4277_st 1.945066901 1.933134038 2.818428903 2.458360311 2.091420837 2.703888291 2.077394057 hsa-miR-4279_st 5.735195753 4.555957853 4.617077131 3.957327091 4.977750745 5.7672041 4.439094896 hsa-miR-4278_st 6.769430522 6.21230605 5.393414183 6.405381498 7.266283499 6.938920314 5.867434879 hsa-miR-4280_st 4.217511889 4.177986642 4.38336885 3.958048382 4.481304882 4.086782868 4.872075886 hsa-miR-4282_st 0.414003371 0.803873241 −0.235498086 −0.56519605 −0.417528894 0.408227053 −0.270863464 hsa-miR-4285_st 11.19117121 10.7788461 10.50026416 11.41126959 11.43660294 11.95910636 11.85641496 hsa-miR-4283_st 8.274272288 7.767795071 7.173974694 8.170720359 8.300815471 8.708288831 8.351162185 hsa-miR-4284_st 14.53463673 15.41007006 14.96709933 14.66963423 14.53079604 15.22239844 14.81581223 hsa-miR-4286_st 14.13825949 14.54600224 13.95215957 14.53970174 13.31428965 13.84741972 13.96222355 hsa-miR-4287_st 4.250551137 5.27016654 4.217148199 5.183834788 5.065523905 5.547011721 5.16394333 hsa-miR-4288_st 4.44515386 5.131605678 5.606988799 4.89996953 4.192276052 4.315456751 4.61593792 hsa-miR-4292_st 7.154388047 6.52788671 6.001495602 6.147113216 7.116515418 7.928765574 7.427084959 hsa-miR-4289_st 4.840611331 6.061450616 6.085938043 7.315498394 6.129057092 5.862832369 6.77065839 hsa-miR-4290_st 7.283698192 5.947016994 5.549512083 6.054037103 7.585893889 6.470195529 5.356387769 hsa-miR-4291_st 5.954604637 6.611914779 5.712379703 6.115296988 7.691933339 6.500027376 6.854483862 hsa-miR-4329_st 5.56478742 5.87164337 5.99687936 6.329544129 5.070309748 5.189209208 5.468667534 hsa-miR-4330_st 5.528112722 5.430515261 3.856110173 5.306409642 4.970604903 5.447401074 5.959457727 hsa-miR-500b_st 3.667298411 4.025630625 4.383865183 3.782416157 3.719773735 4.834009862 3.881715266 hsa-miR-4328_st 3.523442212 3.542135448 3.94829819 3.280353743 3.529277114 2.09856958 1.452698155 Hashimotyo's thyroiditis (HASH); papillary carcinoma (PTC); follicular variant of PTC (FVPTC); follicular carcinoma (FTC); oncocytic follicular carcinoma (OFTC); anaplastic carcinoma (ATC medullary carcinoma (MED).

indicates data missing or illegible when filed

TABLE 4C normalized array data for the 55 benign and malignant FFPE samples Average miRNA Benign lesions Malignant lesions hsa-let-7a_st 14.36000595 14.31198199 hsa-let-7a-star_st 1.817188905 2.034634364 hsa-let-7a-2-star_st 4.848130219 4.810523869 hsa-let-7b_st 13.45339038 13.46708924 hsa-let-7b-star_st 7.052169256 6.303827505 hsa-let-7c_st 14.0768108 14.00524749 hsa-let-7c-star_st 3.944675826 4.072642857 hsa-let-7d_st 13.81633445 13.89989481 hsa-let-7d-star_st 8.179506062 7.567053856 hsa-let-7e_st 12.2186856 12.5052487 hsa-let-7e-star_st 4.367109325 4.152463921 hsa-let-7f_st 13.84568839 13.8708236 hsa-let-7f-1-star_st 4.233470866 3.935010527 hsa-let-7f-2-star_st 1.757216137 2.23118618 hsa-miR-15a_st 9.523730359 10.63249938 hsa-miR-15a-star_st 3.917852022 4.085613882 hsa-miR-16_st 12.97462979 13.70944322 hsa-miR-16-1-star_st 2.99904911 3.740348404 hsa-miR-17_st 9.500384065 10.30568924 hsa-miR-17-star_st 5.283542505 5.698159331 hsa-miR-18a_st 4.141081926 5.032812284 hsa-miR-18a-star_st 4.795553175 4.884815074 hsa-miR-19a-star_st 0.685050416 0.532108606 hsa-miR-19a_st 4.143552632 4.838381769 hsa-miR-19b-1-star_st 2.451457654 2.621841261 hsa-miR-19b_st 9.006935767 9.689618053 hsa-miR-19b-2-star_st 1.018555034 1.137498593 hsa-miR-20a_st 8.89362477 9.588615579 hsa-miR-20a-star_st 5.959174041 5.710046197 hsa-miR-21_st 10.50865483 12.68198373 hsa-miR-21-star_st 5.807031546 6.720356935 hsa-miR-22-star_st 6.689072196 7.494085605 hsa-miR-22_st 11.52342875 12.0204796 hsa-miR-23a-star_st 10.63608279 10.23287553 hsa-miR-23a_st 13.81616627 14.41432249 hsa-miR-24-1-star_st 2.801615889 3.953883 hsa-miR-24_st 12.73350506 13.61325723 hsa-miR-24-2-star_st 4.615385083 6.158120747 hsa-miR-25-star_st 12.33778526 11.68803427 hsa-miR-25_st 10.19509648 10.49485004 hsa-miR-26a_st 14.61398465 14.48916527 hsa-miR-26a-1-star_st 1.854990302 1.453798647 hsa-miR-26b_st 11.29214694 11.52330198 hsa-miR-26b-star_st 4.850227976 5.065710184 hsa-miR-27a-star_st 4.965521181 5.286398414 hsa-miR-27a_st 11.22486946 12.53462951 hsa-miR-28-5p_st 7.868477936 8.605030726 hsa-miR-28-3p_st 6.205295102 6.674609956 hsa-miR-29a-star_st 1.574704733 1.841258599 hsa-miR-29a_st 12.84143789 13.58290488 hsa-miR-30a_st 12.02183057 12.10230006 hsa-miR-30a-star_st 9.961700524 8.854338003 hsa-miR-31_st 8.523069812 10.1455091 hsa-miR-31-star_st 2.222678966 4.612984691 hsa-miR-32_st 0.72558191 1.35229567 hsa-miR-32-star_st 2.970239513 2.776181659 hsa-miR-33a_st 0.37861614 0.6924047 hsa-miR-33a-star_st 2.101622678 3.023222763 hsa-miR-92a-1-star_st 8.017692542 7.436092652 hsa-miR-92a_st 10.65750464 10.80178948 hsa-miR-92a-2-star_st 9.102149194 8.505089146 hsa-miR-93_st 9.159293092 9.963608318 hsa-miR-93-star_st 4.376632867 4.973263034 hsa-miR-95_st 7.323539117 6.976585435 hsa-miR-96_st 4.900564549 5.940308881 hsa-miR-96-star_st 3.234687115 3.077770058 hsa-miR-98_st 8.966376043 9.888968078 hsa-miR-99a_st 11.92738151 12.44015979 hsa-miR-99a-star_st 4.070995307 4.952788995 hsa-miR-100_st 11.9698056 12.21937804 hsa-miR-100-star_st 2.17563109 1.904357889 hsa-miR-101-star_st 2.093249813 2.458609388 hsa-miR-101_st 4.781687089 5.603263242 hsa-miR-29b-1-star_st 5.619415955 6.085087062 hsa-miR-29b_st 10.71743423 11.66840776 hsa-miR-29b-2-star_st 7.591698518 7.664428275 hsa-miR-103-2-star_st 4.636666583 5.116206973 hsa-miR-103_st 12.05908493 12.55126282 hsa-miR-105_st 2.00205694 2.014277348 hsa-miR-105-star_st 2.876309165 2.704470738 hsa-miR-106a_st 9.678844073 10.32064486 hsa-miR-106a-star_st 1.313898069 1.311817168 hsa-miR-107_st 11.83968896 12.41731811 hsa-miR-16-2-star_st 3.100002226 3.990160093 hsa-miR-192_st 6.616238334 7.209948907 hsa-miR-192-star_st 3.51811829 3.737829775 hsa-miR-196a_st 2.205417441 3.202438077 hsa-miR-197_st 7.752098414 7.05667193 hsa-miR-198_st 12.20408767 11.82988454 hsa-miR-199a-5p_st 9.09156334 10.01581872 hsa-miR-199a-3p_st 10.41531984 11.23108944 hsa-miR-208a_st 2.426923226 2.866876966 hsa-miR-129-5p_st 11.37107956 10.73008473 hsa-miR-129-star_st 3.990282192 4.219661375 hsa-miR-148a-star_st 4.318157258 4.562739552 hsa-miR-148a_st 9.727259974 10.55115809 hsa-miR-30c_st 13.21568699 12.99368195 hsa-miR-30c-2-star_st 7.508318158 7.105102486 hsa-miR-30d_st 11.80359334 12.17102503 hsa-miR-30d-star_st 2.07699433 2.351079747 hsa-miR-139-5p_st 7.018950578 5.92709119 hsa-miR-139-3p_st 7.694936312 7.147328758 hsa-miR-147_st 4.165365984 3.90638249 hsa-miR-7_st 8.427198768 6.266205738 hsa-miR-7-1-star_st 5.912670765 6.303490609 hsa-miR-7-2-star_st 6.588741297 5.697015591 hsa-miR-10a_st 7.611506522 8.371969516 hsa-miR-10a-star_st 3.996873331 4.184409763 hsa-miR-10b_st 8.299153562 9.492010377 hsa-miR-10b-star_st 3.623172296 3.897742826 hsa-miR-34a_st 8.639499617 10.28404006 hsa-miR-34a-star_st 4.948757717 6.458906078 hsa-miR-181a_st 11.8162237 12.30958671 hsa-miR-181a-2-star_st 7.49108462 8.51734465 hsa-miR-181b_st 10.54596321 11.07333877 hsa-miR-181c_st 7.714549502 8.726418322 hsa-miR-181c-star_st 6.15088745 6.749584529 hsa-miR-182_st 7.854141892 9.116388045 hsa-miR-182-star_st 2.071525858 1.728213696 hsa-miR-183_st 5.037678916 5.668334307 hsa-miR-183-star_st 6.8335086 6.70005607 hsa-miR-187-star_st 9.653086446 9.162341913 hsa-miR-187_st 3.832697742 4.116541122 hsa-miR-196a-star_st 4.139255612 4.713887099 hsa-miR-199b-5p_st 5.734094768 6.66582012 hsa-miR-199b-3p_st 10.2965265 11.30516471 hsa-miR-203_st 6.463218637 6.498685112 hsa-miR-204_st 7.152259387 5.50936759 hsa-miR-205_st 4.167524329 4.532847116 hsa-miR-205-star_st 4.928554113 4.828048623 hsa-miR-210_st 12.49990996 12.07385469 hsa-miR-211_st 5.161069512 4.953134599 hsa-miR-212_st 5.850386233 6.237663924 hsa-miR-181a-star_st 4.446572243 5.664004911 hsa-miR-214-star_st 4.661216959 5.325425233 hsa-miR-214_st 10.26091254 10.06821253 hsa-miR-215_st 3.692075806 4.452383278 hsa-miR-216a_st 2.006819738 2.215754821 hsa-miR-217_st 2.337664425 2.63315841 hsa-miR-218_st 3.63808555 4.853644376 hsa-miR-218-1-star_st 1.961569664 1.558810001 hsa-miR-218-2-star_st 3.307895039 2.95864268 hsa-miR-219-5p_st 0.558983952 0.582593709 hsa-miR-219-1-3p_st 4.353658641 4.606037137 hsa-miR-220a_st 2.04233455 2.155153308 hsa-miR-221-star_st 5.351253871 8.067211581 hsa-miR-221_st 11.92279588 13.8201505 hsa-miR-222-star_st 5.725998902 6.531098523 hsa-miR-222_st 11.65865636 13.62259088 hsa-miR-223-star_st 2.709788027 3.24220149 hsa-miR-223_st 8.411456875 9.035877876 hsa-miR-224_st 6.111303772 7.102224934 hsa-miR-224-star_st 5.065366846 5.377721206 hsa-miR-200b-star_st 6.396031008 5.991071351 hsa-miR-200b_st 10.44380414 10.62028303 hsa-let-7g_st 13.06680131 13.24754752 hsa-let-7g-star_st 5.228588386 4.868016299 hsa-let-7i_st 13.40307965 13.81911381 hsa-let-7i-star_st 5.725209102 6.113275002 hsa-miR-1_st 3.605902148 3.667255452 hsa-miR-15b_st 10.25425488 10.25040802 hsa-miR-15b-star_st 3.073962052 2.547676394 hsa-miR-23b-star_st 5.181113699 5.135602016 hsa-miR-23b_st 13.98359691 14.43745778 hsa-miR-27b-star_st 5.701586643 6.68992006 hsa-miR-27b_st 11.51233731 12.4572577 hsa-miR-30b_st 11.74389887 12.14485003 hsa-miR-30b-star_st 8.81777762 8.371591203 hsa-miR-122_st 3.646502561 3.11823204 hsa-miR-122-star_st 1.619469872 1.837565558 hsa-miR-124-star_st 4.93211131 4.833770967 hsa-miR-124_st 7.972483773 7.801098825 hsa-miR-125b_st 14.37624126 14.44963404 hsa-miR-125b-1-star_st 11.75832583 11.3109495 hsa-miR-128_st 7.527388925 7.902519075 hsa-miR-130a-star_st 1.538371677 1.462469102 hsa-miR-130a_st 10.9465824 11.06460559 hsa-miR-132-star_st 2.372952819 3.369454077 hsa-miR-132_st 6.097848644 7.163642343 hsa-miR-133a_st 5.067413225 4.642066769 hsa-miR-135a_st 1.15975216 2.22073332 hsa-miR-135a-star_st 12.22633278 11.72121432 hsa-miR-137_st 1.255264255 1.492345231 hsa-miR-138_st 10.89537098 9.93510521 hsa-miR-138-2-star_st 3.820287956 4.076322371 hsa-miR-140-5p_st 4.091314417 5.22161458 hsa-miR-140-3p_st 10.50572604 10.72876276 hsa-miR-141-star_st 2.211640062 2.203296777 hsa-miR-141_st 8.444729901 8.89520913 hsa-miR-142-5p_st 3.357937041 4.711509093 hsa-miR-142-3p_st 0.584297115 0.830877789 hsa-miR-143-star_st 6.431750149 6.366869822 hsa-miR-143_st 11.96506029 12.21085325 hsa-miR-144-star_st 2.589339021 2.615721951 hsa-miR-144_st 1.257976317 0.783692809 hsa-miR-145_st 13.19010848 12.85861061 hsa-miR-145-star_st 4.996042403 5.285051949 hsa-miR-152_st 9.860515062 9.72840712 hsa-miR-153_st 1.39098679 1.597191112 hsa-miR-191_st 12.39382767 12.92127283 hsa-miR-191-star_st 6.045325279 5.868049182 hsa-miR-9_st −0.037423131 0.323639859 hsa-miR-9-star_st 1.862780771 1.992323554 hsa-miR-125a-5p_st 13.24316542 13.27096846 hsa-miR-125a-3p_st 11.86938739 11.51258355 hsa-miR-125b-2-star_st 9.209754481 9.008151793 hsa-miR-126-star_st 0.587084425 1.16320053 hsa-miR-126_st 13.11731956 13.11019041 hsa-miR-127-5p_st 5.708661536 6.148581495 hsa-miR-127-3p_st 5.963094836 6.502955865 hsa-miR-129-3p_st 2.925722079 3.577022621 hsa-miR-134_st 8.238898408 7.975684141 hsa-miR-136_st 0.436691213 0.750769397 hsa-miR-136-star_st 1.18821308 1.646729981 hsa-miR-138-1-star_st 7.63398959 6.723501115 hsa-miR-146a_st 8.000275818 9.489633492 hsa-miR-146a-star_st 0.599256679 1.438452988 hsa-miR-149_st 6.561947984 6.824176008 hsa-miR-149-star_st 15.94959873 15.45479213 hsa-miR-150_st 9.786207 9.650047292 hsa-miR-150-star_st 13.05492785 12.70584759 hsa-miR-154_st 3.877395393 3.839602042 hsa-miR-154-star_st 3.206254747 2.993683876 hsa-miR-184_st 7.42739076 7.018936933 hsa-miR-185_st 9.38739608 9.269716021 hsa-miR-185-star_st 9.740932048 8.766964677 hsa-miR-186_st 4.442838044 4.275145719 hsa-miR-186-star_st 0.087196561 0.839547882 hsa-miR-188-5p_st 6.728698341 6.882128003 hsa-miR-188-3p_st 3.474517048 3.608866094 hsa-miR-190_st −0.053777817 −0.299015248 hsa-miR-193a-5p_st 12.47197392 11.63882799 hsa-miR-193a-3p_st 6.690228177 6.929106052 hsa-miR-194_st −6.702817284 7.08213949 hsa-miR-195_st 10.65287639 10.99785423 hsa-miR-195-star_st 4.719264269 5.119920239 hsa-miR-206_st 5.356578578 5.440984838 hsa-miR-320a_st 12.32287691 12.01672633 hsa-miR-200c-star_st 3.403121493 3.35018893 hsa-miR-200c_st 13.30675633 13.06693526 hsa-miR-155_st 8.442115751 9.050269641 hsa-miR-155-star_st 2.019873803 2.076690306 hsa-miR-194-star_st 8.342531305 7.827253713 hsa-miR-106b_st 8.645144215 9.541269309 hsa-miR-106b-star_st 7.409394541 7.546819664 hsa-miR-29c-star_st 7.149799152 7.290572146 hsa-miR-29c_st 10.79483359 11.23178028 hsa-miR-30c-1-star_st 10.447203 10.39730286 hsa-miR-200a-star_st 5.731292411 5.988460145 hsa-miR-200a_st 9.169758229 9.503851262 hsa-miR-302a-star_st 2.372057591 2.370495167 hsa-miR-302a_st 1.855387217 2.038060651 hsa-miR-219-2-3p_st 6.739852398 6.74831764 hsa-miR-34b-star_st 3.840904487 5.21965384 hsa-miR-34b_st 6.547213084 5.942852905 hsa-miR-34c-5p_st 2.090522064 2.678820887 hsa-miR-34c-3p_st 6.086653049 5.905086837 hsa-miR-299-5p_st 5.363201505 5.203675845 hsa-miR-299-3p_st 6.959936198 6.82563734 hsa-miR-301a_st 3.051935466 4.532745543 hsa-miR-99b_st 10.70845538 11.15355835 hsa-miR-99b-star_st 7.977755574 7.721754645 hsa-miR-296-5p_st 3.825898995 4.157035884 hsa-miR-296-3p_st 11.84964963 11.36519002 hsa-miR-130b-star_st 4.426314454 3.997836205 hsa-miR-130b_st 7.786698895 8.06324078 hsa-miR-30e_st 9.146166551 9.513823359 hsa-miR-30e-star_st 8.94504654 8.420921138 hsa-miR-26a-2-star_st 0.448195516 0.886994323 hsa-miR-361-5p_st 10.63653492 10.82243064 hsa-miR-361-3p_st 5.338284351 5.619177786 hsa-miR-362-5p_st 6.457708861 6.747031759 hsa-miR-362-3p_st 2.549692831 3.482225846 hsa-miR-363-star_st 10.16128719 9.740192497 hsa-miR-363_st 4.586469182 5.158970832 hsa-miR-365_st 2.846214258 2.76223775 hsa-miR-365-star_st 11.24944871 10.70587958 hsa-miR-302b-star_st 3.539467751 3.460255223 hsa-miR-302b_st −0.263529977 0.53926022 hsa-miR-302c-star_st 7.863854974 7.319376018 hsa-miR-302c_st 1.216885909 1.718478687 hsa-miR-302d-star_st 6.498846388 6.395437343 hsa-miR-302d_st 0.714797032 1.194972082 hsa-miR-367-star_st 0.877941639 0.877505077 hsa-miR-367_st 1.421065963 1.397357436 hsa-miR-376c_st 3.565402716 4.789057213 hsa-miR-369-5p_st 2.905969783 3.759062494 hsa-miR-369-3p_st 0.918124726 0.537099381 hsa-miR-370_st 11.03403163 10.54839769 hsa-miR-371-5p_st 11.89257045 11.19298009 hsa-miR-371-3p_st 4.502810974 3.735324728 hsa-miR-372_st 2.868332675 2.849718395 hsa-miR-373-star_st 11.17516631 10.26133923 hsa-miR-373_st 4.640220277 4.701820472 hsa-miR-374a_st 2.467623526 2.96858071 hsa-miR-374a-star_st 2.604831429 2.597379957 hsa-miR-375_st 4.398265966 6.827059343 hsa-miR-376a-star_st 0.507486272 0.392805453 hsa-miR-376a_st 3.313087786 3.970213789 hsa-miR-377-star_st 4.020741665 4.154103103 hsa-miR-377_st 2.068010287 2.61569932 hsa-miR-378-star_st 5.247508878 5.110442055 hsa-miR-378_st 8.410030576 8.522842373 hsa-miR-379_st 5.171820275 5.46418133 hsa-miR-379-star_st 2.342551084 2.04349047 hsa-miR-380-star_st 1.956654661 1.696314678 hsa-miR-380_st 0.986550906 0.551846428 hsa-miR-381_st 5.01019789 5.256109977 hsa-miR-382_st 6.686858479 6.752161838 hsa-miR-383_st 5.73743282 5.619950727 hsa-miR-340_st 2.759206667 4.245817534 hsa-miR-340-star_st 1.231739032 1.606564863 hsa-miR-330-5p_st 5.671343998 5.840636639 hsa-miR-330-3p_st 6.043678256 6.295562293 hsa-miR-328_st 7.843122583 7.298096324 hsa-miR-342-5p_st 5.148144481 5.065987529 hsa-miR-342-3p_st 9.812784392 10.37863789 hsa-miR-337-5p_st 2.723879131 2.765987114 hsa-miR-337-3p_st 3.853089832 4.011466473 hsa-miR-323-5p_st 11.02897044 10.51777655 hsa-miR-323-3p_st 3.303864373 3.924228136 hsa-miR-326_st 6.919923767 6.514124006 hsa-miR-151-5p_st 11.01794237 11.41683181 hsa-miR-151-3p_st 7.931115259 8.705733794 hsa-miR-135b_st 1.341991211 2.074222341 hsa-miR-135b-star_st 6.231949017 6.246922171 hsa-miR-148b-star_st 1.785330831 2.205730565 hsa-miR-148b_st 8.253236805 8.537720847 hsa-miR-331-5p_st 5.996544431 6.293113779 hsa-miR-331-3p_st 8.911242463 9.333572676 hsa-miR-324-5p_st 8.218170272 8.790495408 hsa-miR-324-3p_st 8.246863486 8.246251943 hsa-miR-338-5p_st 4.598152191 5.531917463 hsa-miR-338-3p_st 3.625466221 4.546999732 hsa-miR-339-5p_st 7.904657223 8.03347372 hsa-miR-339-3p_st 8.428769453 8.525128595 hsa-miR-335_st 7.349563245 8.63764613 hsa-miR-335-star_st 2.579882162 2.822031762 hsa-miR-133b_st 5.507453349 5.063207234 hsa-miR-325_st 3.374977587 3.506824457 hsa-miR-345_st 9.947792337 9.575654547 hsa-miR-346_st 9.252844035 8.515788731 hsa-miR-384_st 0.705946878 0.749499399 hsa-miR-196b_st 2.261522752 2.507888206 hsa-miR-196b-star_st 6.115599869 6.100450539 hsa-miR-422a_st 8.970061907 8.781848497 hsa-miR-423-5p_st 13.22560469 12.7766514 hsa-miR-423-3p_st 9.444694731 9.515284512 hsa-miR-424_st 5.173778206 6.558926603 hsa-miR-424-star_st 8.255107886 8.110617308 hsa-miR-425_st 7.675481843 9.000293305 hsa-miR-425-star_st 7.98460387 7.945211866 hsa-miR-18b_st 3.527288828 3.873630423 hsa-miR-18b-star_st 4.115489988 4.419179605 hsa-miR-20b_st 7.573277105 8.283015486 hsa-miR-20b-star_st 4.727461997 4.792609471 hsa-miR-448_st 2.103855381 2.210141362 hsa-miR-429_st 4.515379148 5.511999804 hsa-miR-449a_st 3.110645728 3.277116245 hsa-miR-450a_st 2.551079533 3.324852066 hsa-miR-431_st 2.550852409 3.004319505 hsa-miR-431-star_st 6.268771623 6.321666885 hsa-miR-433_st 4.554910789 4.969801894 hsa-miR-329_st 2.746201709 3.877841069 hsa-miR-451_st 12.5547106 12.02445188 hsa-miR-452_st 5.784024409 6.550204222 hsa-miR-452-star_st 3.622743958 3.186990324 hsa-miR-409-5p_st 3.330430107 3.623972951 hsa-miR-409-3p_st 5.503185818 5.942186892 hsa-miR-412_st 4.206326729 4.362758974 hsa-miR-410_st 3.259684019 3.643967998 hsa-miR-376b_st 1.828883403 2.459601136 hsa-miR-483-5p_st 11.40324762 11.06001912 hsa-miR-483-3p_st 6.916828196 6.522209625 hsa-miR-484_st 7.171207884 7.393697906 hsa-miR-485-5p_st 6.00157946 6.034655041 hsa-miR-485-3p_st 5.39893985 5.441357088 hsa-miR-486-5p_st 8.817967119 7.680934994 hsa-miR-486-3p_st 10.16038619 9.324192829 hsa-miR-487a_st 5.190894234 5.234422767 hsa-miR-488-star_st 2.037661041 2.031702259 hsa-miR-488_st 1.917044666 2.074173654 hsa-miR-489_st 8.065921716 8.172967587 hsa-miR-490-5p_st 6.754727362 6.554242182 hsa-miR-490-3p_st 4.591119855 4.858750807 hsa-miR-491-5p_st 9.174267442 8.827885194 hsa-miR-491-3p_st 4.817072369 4.756033597 hsa-miR-511_st 0.582438965 0.716293373 hsa-miR-146b-5p_st 8.65119709 12.64738009 hsa-miR-146b-3p_st 3.914402013 6.123201923 hsa-miR-202-star_st −0.781474877 −0.007931765 hsa-miR-202_st 8.491867741 8.241607401 hsa-miR-492_st 7.956878031 7.899261836 hsa-miR-493-star_st 3.108410034 4.277607706 hsa-miR-493_st 4.977110017 4.958178529 hsa-miR-432_st 6.760195763 6.744838142 hsa-miR-432-star_st 4.779154597 4.709849583 hsa-miR-494_st 14.93967888 14.97979071 hsa-miR-495_st 2.336665394 3.336559005 hsa-miR-496_st 1.467169895 1.393316839 hsa-miR-193b-star_st 11.48400641 10.73433048 hsa-miR-193b_st 7.937207432 8.284766042 hsa-miR-497_st 8.895613769 9.029656096 hsa-miR-497-star_st 2.281978967 1.832596009 hsa-miR-181d_st 9.070447864 9.349844873 hsa-miR-512-5p_st 4.259904447 4.147121496 hsa-miR-512-3p_st 4.586526379 4.211378463 hsa-miR-498_st 11.35242614 10.80489493 hsa-miR-520e_st 1.204578854 1.686790871 hsa-miR-515-5p_st 1.970304748 2.393561669 hsa-miR-515-3p_st 3.126241548 3.481186768 hsa-miR-519c-star_st 5.720072666 5.589378134 hsa-miR-519c_st 3.71700652 3.797069026 hsa-miR-520f_st 1.131815056 1.691206685 hsa-miR-519c-5p_st 5.309746638 5.003525016 hsa-miR-519c-3p_st 0.22969516 −0.113714668 hsa-miR-520a-5p_st 3.638243827 3.334189211 hsa-miR-520a-3p_st 2.228775692 2.327561233 hsa-miR-526b_st 5.017040378 4.595789821 hsa-miR-526b-star_st 0.96461501 1.2883939 hsa-miR-519b-5p_st 5.816569346 5.485221487 hsa-miR-519b-3p_st 1.582189453 1.35015253 hsa-miR-525-5p_st 5.25469618 4.941976647 hsa-miR-525-3p_st 2.904452936 2.63710265 hsa-miR-523-star_st 5.223994896 4.55164185 hsa-miR-523_st 1.349865804 1.309785593 hsa-miR-518f-star_st 5.975454364 5.920854764 hsa-miR-518f_st 1.138901913 1.124159574 hsa-miR-520b_st 1.179636607 0.989989281 hsa-miR-518b_st 3.744046243 3.185822688 hsa-miR-526a_st 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hsa-miR-1228-star_st 16.00703846 15.55054414 hsa-miR-1228_st 8.183898455 7.754592554 hsa-miR-1229_st 7.8660255 7.425379155 hsa-miR-1231_st 13.99160279 13.29293761 hsa-miR-1233_st 7.140881909 6.813134409 hsa-miR-1234_st 6.978386089 6.703978411 hsa-miR-1236_st 5.757283186 5.562027912 hsa-miR-1237_st 8.049528369 7.501759124 hsa-miR-1238_st 6.929779579 6.674332143 hsa-miR-1200_st 5.018956665 4.660480029 hsa-miR-1201_st 7.83962411 8.60963805 hsa-miR-1202_st 13.13333492 12.59373454 hsa-miR-1203_st 8.407178357 8.308694904 hsa-miR-663b_st 10.18073743 10.10219451 hsa-miR-1204_st 5.038031282 4.657796701 hsa-miR-1205_st 3.414346931 3.533583038 hsa-miR-1206_st 0.654108253 1.265207014 hsa-miR-1207-5p_st 15.09383225 14.67994122 hsa-miR-1207-3p_st 3.967191169 3.376750907 hsa-miR-1208_st 8.547871045 7.850096533 hsa-miR-548e_st 0.473225938 0.815593405 hsa-miR-548j_st 3.359555166 2.980872631 hsa-miR-1285_st 12.97329191 12.86031885 hsa-miR-1286_st 8.330094451 8.000560127 hsa-miR-1287_st 5.796143688 5.951267014 hsa-miR-1289_st 4.644854383 4.753867218 hsa-miR-1290_st 9.369553951 9.015379911 hsa-miR-1291_st 8.258068261 8.11301893 hsa-miR-548k_st 2.172935385 2.681926565 hsa-miR-1293_st 7.784448988 7.443396866 hsa-miR-1294_st 5.615706602 5.430705677 hsa-miR-1295_st 5.72171546 5.634436005 hsa-miR-1297_st 0.694687517 1.273957483 hsa-miR-1299_st 5.362501545 5.034147137 hsa-miR-5481_st 4.090651354 3.99206717 hsa-miR-1302_st 1.757901869 1.705103066 hsa-miR-1303_st 10.5092456 10.16222173 hsa-miR-1304_st 6.383188311 6.731791893 hsa-miR-1305_st 2.218622047 2.295353425 hsa-miR-1243_st 3.115792724 2.908600169 hsa-miR-548f_st 0.934036318 0.786744918 hsa-miR-1244_st 8.089934765 8.607202837 hsa-miR-1245_st 3.227053374 3.230305643 hsa-miR-1246_st 13.26254202 13.10299414 hsa-miR-1247_st 6.519744424 6.19193942 hsa-miR-1248_st 9.571458845 9.931793782 hsa-miR-1249_st 4.697464396 4.741051931 hsa-miR-1250_st 8.601722913 8.265194057 hsa-miR-1251_st 4.332141423 4.845112511 hsa-miR-1253_st 4.352494892 4.197114342 hsa-miR-1254_st 11.07447655 10.84067505 hsa-miR-1255a_st 4.71253267 4.900448328 hsa-miR-1256_st 2.921954678 3.257665828 hsa-miR-1257_st 3.738524139 3.862628094 hsa-miR-1258_st 3.980487676 4.024276093 hsa-miR-1259_st 1.793876877 2.134496387 hsa-miR-1260_st 10.51371892 10.52978062 hsa-miR-548g_st 0.427863344 0.639394206 hsa-miR-1261_st 7.500943582 7.388669793 hsa-miR-1262_st 2.385426572 2.18526919 hsa-miR-1263_st 3.328855641 2.977757046 hsa-miR-548n_st 1.476271083 1.519100638 hsa-miR-548m_st 1.986854867 2.284258132 hsa-miR-1265_st 4.836064174 4.666927642 hsa-miR-548o_st 1.719377422 1.288016821 hsa-miR-1266_st 8.713590792 8.222220746 hsa-miR-1267_st 3.855578054 3.480577888 hsa-miR-1268_st 15.51819611 15.04306878 hsa-miR-1269_st 4.925081179 4.860540477 hsa-miR-1270_st 6.2456038 6.119878209 hsa-miR-1272_st 3.323982487 3.299811978 hsa-miR-1273_st 10.89348275 10.8013459 hsa-miR-1274a_st 9.866616109 10.95409808 hsa-miR-548h_st 2.708976669 3.075521318 hsa-miR-1275_st 14.04621179 13.66733549 hsa-miR-1276_st 5.91403493 5.705786102 hsa-miR-302e_st 2.775251808 2.420822294 hsa-miR-302f_st 1.051179195 1.454558008 hsa-miR-1277_st 1.921769944 1.875581452 hsa-miR-548p_st 1.26545941 1.412701566 hsa-miR-548i_st 4.337002107 4.422845234 hsa-miR-1278_st 3.28235357 3.422861193 hsa-miR-1279_st 2.655743736 3.153072811 hsa-miR-1274b_st 13.40685468 14.05745456 hsa-miR-1281_st 9.162432854 8.628380901 hsa-miR-1282_st 3.720097483 4.002137534 hsa-miR-1284_st 3.906481147 3.839660908 hsa-miR-1288_st 4.057295362 4.309374769 hsa-miR-1292_st 12.54990676 12.12104333 hsa-miR-1252_st 1.390910014 1.641722688 hsa-miR-1255b_st 7.861905402 8.2114196 hsa-miR-1280_st 14.99196599 14.94288127 hsa-miR-1308_st 14.96349933 15.13166088 hsa-miR-664-star_st 9.899383779 9.542708113 hsa-miR-664_st 5.466549309 5.260588583 hsa-miR-1306_st 6.8937086 6.604984224 hsa-miR-1307_st 13.98022262 13.37529099 hsa-miR-513b_st 10.57485724 10.45748832 hsa-miR-513c_st 8.74116087 8.349383978 hsa-miR-1321_st 7.503803552 7.073330049 hsa-miR-1322_st 3.669120279 3.556889047 hsa-miR-720_st 15.04724175 15.07056161 hsa-miR-1197_st 1.963900545 2.054211227 hsa-miR-1324_st 1.455355935 1.888812334 hsa-miR-1469_st 16.0183398 15.54754242 hsa-miR-1470_st 5.754747808 5.158367754 hsa-miR-1471_st 10.86730917 10.48569035 hsa-miR-1537_st 1.182421653 1.412645392 hsa-miR-1538_st 7.788283814 7.622768161 hsa-miR-1539_st 5.970294118 5.973367867 hsa-miR-103-as_st 2.508175856 2.266885141 hsa-miR-320d_st 9.717392149 9.756189985 hsa-miR-1825_st 6.7812821 6.397975378 hsa-miR-1826_st 15.95940582 15.68532265 hsa-miR-1827_st 4.494451222 5.671983153 hsa-miR-1908_st 16.09437218 15.6685715 hsa-miR-1909-star_st 9.074029033 8.420395636 hsa-miR-1909_st 14.82498487 14.31704517 hsa-miR-1910_st 10.19701023 9.165819315 hsa-miR-1911_st 3.452208679 3.530335335 hsa-miR-1911-star_st 4.838918994 4.939768155 hsa-miR-1912_st 3.889736968 4.001458712 hsa-miR-1913_st 8.208934885 7.816539543 hsa-miR-1914_st 6.948960342 6.641912822 hsa-miR-1914-star_st 12.76141618 12.28137688 hsa-miR-1915-star_st 7.880688641 7.371510327 hsa-miR-1915_st 16.09441936 15.65666258 hsa-miR-1972_st 13.28967445 13.0889173 hsa-miR-1973_st 14.46489111 14.71345884 hsa-miR-1975_st 15.83144955 15.609638 hsa-miR-1976_st 7.955652531 7.324338717 hsa-miR-1979_st 15.17466845 14.92056909 hsa-miR-2052_st 0.261150813 0.879065556 hsa-miR-2053_st 1.566913167 1.772546409 hsa-miR-2054_st −0.371432679 −0.054846939 hsa-miR-2110_st 10.7596285 10.32133115 hsa-miR-2114_st 2.275045318 2.652793175 hsa-miR-2114-star_st 5.893322871 6.090650086 hsa-miR-2115_st 1.669248276 2.025263831 hsa-miR-2115-star_st 7.86781663 7.517753205 hsa-miR-2116_st 5.382899873 5.301283894 hsa-miR-2116-star_st 4.313940938 4.570962705 hsa-miR-2117_st 1.989389206 1.81859151 hsa-miR-548q_st 7.909367287 7.135060897 hsa-miR-2276_st 10.04754803 9.612458781 hsa-miR-2277_st 8.843380123 8.242791768 hsa-miR-2278_st 5.46905257 5.172606924 hsa-miR-711_st 11.50174419 10.96229128 hsa-miR-718_st 7.442014014 7.163231535 hsa-miR-2861_st 16.09867509 15.67854395 hsa-miR-2909_st 2.843929561 3.059059612 hsa-miR-3115_st 1.737701734 1.895906102 hsa-miR-3116_st 5.846455429 5.994577546 hsa-miR-3117_st 2.792558003 2.7665622 hsa-miR-3118_st 1.966621914 2.355950452 hsa-miR-3119_st 1.064257222 0.979500777 hsa-miR-3120_st 5.873825771 5.522932348 hsa-miR-3121_st 6.72575369 6.585337578 hsa-miR-3122_st 11.19876638 10.60586491 hsa-miR-3123_st 0.811165914 −0.188615176 hsa-miR-3124_st 11.71964185 11.16453936 hsa-miR-548s_st 1.466493177 1.689971077 hsa-miR-3125_st 6.876702817 6.818744686 hsa-miR-3126-5p_st 11.6003181 11.27378363 hsa-miR-3126-3p_st 4.320522288 4.289572758 hsa-miR-3127_st 9.124840533 8.868822515 hsa-miR-3128_st 2.735917851 2.578431728 hsa-miR-3129_st 3.581165201 3.371565647 hsa-miR-3130-5p_st 6.60574064 6.353294536 hsa-miR-3130-3p_st 7.726838449 7.18848278 hsa-miR-3131_st 11.91732799 11.41437778 hsa-miR-3132_st 8.733534161 8.548941914 hsa-miR-3133_st 2.379308925 2.704068889 hsa-miR-378b_st 8.681317348 8.650627772 hsa-miR-3134_st 1.486292562 1.585026115 hsa-miR-3135_st 6.388081763 5.945197855 hsa-miR-466_st 5.570854799 5.542584775 hsa-miR-3136_st 6.025449661 5.835307058 hsa-miR-544b_st 2.395651967 2.329439708 hsa-miR-3137_st 10.77465477 10.2263542 hsa-miR-3138_st 10.68211816 10.28813745 hsa-miR-3139_st 2.392149157 2.319510504 hsa-miR-3140_st 4.519529715 4.369874672 hsa-miR-548t_st 2.16050833 2.590748278 hsa-miR-3141_st 15.23935882 14.69454712 hsa-miR-3142_st 1.230043669 1.403627739 hsa-miR-3143_st 0.40032393 0.585435203 hsa-miR-548u_st 1.153531581 1.827011911 hsa-miR-3144-5p_st 4.500348126 4.861469455 hsa-miR-3144-3p_st 2.606286299 2.956528592 hsa-miR-3145_st 0.093993449 0.518199564 hsa-miR-1273c_st 10.04905189 9.856293901 hsa-miR-3146_st 3.4426515 3.404563434 hsa-miR-3147_st 11.26421121 10.85330475 hsa-miR-548v_st 2.734247475 3.018309976 hsa-miR-3148_st 4.747538073 4.463907972 hsa-miR-3149_st 2.666562564 2.768578604 hsa-miR-3150_st 9.397553648 8.840212022 hsa-miR-3151_st 11.32817214 10.69238559 hsa-miR-3152_st 6.838886942 6.526417665 hsa-miR-3153_st 9.393915286 8.916847838 hsa-miR-3074_st 4.493265824 4.089405742 hsa-miR-3154_st 11.43417874 11.02236951 hsa-miR-3155_st 6.870088743 6.714149239 hsa-miR-3156_st 9.93990287 10.0849857 hsa-miR-3157_st 5.38163833 5.094757246 hsa-miR-3158_st 4.236335397 4.274469069 hsa-miR-3159_st 4.040287102 3.801415135 hsa-miR-3160_st 5.161150506 5.378709596 hsa-miR-3161_st 6.51169066 6.557791334 hsa-miR-3162_st 13.59267667 13.14054899 hsa-miR-3163_st 7.645100343 7.48987569 hsa-miR-3164_st 6.163469175 6.189816592 hsa-miR-3165_st 6.882731374 6.535597214 hsa-miR-3166_st 3.973883057 4.118281598 hsa-miR-1260b_st 13.93656531 13.99271742 hsa-miR-3167_st 1.377189008 1.42325091 hsa-miR-3168_st 2.194258898 2.15096857 hsa-miR-3169_st 3.70478395 3.682058672 hsa-miR-3170_st 6.064431816 5.836019309 hsa-miR-3171_st 2.352321358 2.025211561 hsa-miR-3172_st 15.23599263 15.04216648 hsa-miR-3173_st 9.032862067 8.749245336 hsa-miR-1193_st 9.830435489 9.725716769 hsa-miR-323b-5p_st 7.434430581 7.205363706 hsa-miR-323b-3p_st 2.357569768 2.866142211 hsa-miR-3174_st 6.173342148 6.173925415 hsa-miR-3175_st 12.95023052 12.79495123 hsa-miR-3176_st 10.61297987 10.65372575 hsa-miR-3177_st 11.49185794 11.07616235 hsa-miR-3178_st 15.64109228 15.24205841 hsa-miR-3179_st 3.289533778 2.950144271 hsa-miR-3180-5p_st 7.725233167 7.083215398 hsa-miR-3180-3p_st 14.81867448 14.0986637 hsa-miR-548w_st 6.223862497 6.001907668 hsa-miR-3181_st 8.412913395 7.93524875 hsa-miR-3182_st 2.946246872 3.014694646 hsa-miR-3183_st 3.775060955 3.752226002 hsa-miR-3184_st 9.50508687 9.123334445 hsa-miR-3185_st 15.22528591 14.55369878 hsa-miR-3065-5p_st 2.925847678 4.183884524 hsa-miR-3065-3p_st 3.813962114 4.624189553 hsa-miR-3186-5p_st 4.019883608 4.156746826 hsa-miR-3186-3p_st 8.641386086 8.360382996 hsa-miR-3187_st 12.62991206 11.97054122 hsa-miR-3188_st 12.96496319 12.37641503 hsa-miR-3189_st 7.393244154 6.98199517 hsa-miR-320c_st 9.526714554 9.465066146 hsa-miR-3190-5p_st 9.796876407 9.541241883 hsa-miR-3190-3p_st 10.01846168 9.754508553 hsa-miR-3191_st 11.40731033 11.18992752 hsa-miR-3192_st 8.679024367 8.447355999 hsa-miR-3193_st 5.958950748 5.926624483 hsa-miR-3194_st 10.4157656 10.01084942 hsa-miR-3195_st 12.82491936 12.24024715 hsa-miR-3196_st 16.13437134 15.7220917 hsa-miR-548x_st 0.378130116 0.540103906 hsa-miR-3197_st 15.02973494 14.78116356 hsa-miR-3198_st 9.632039821 9.076169918 hsa-miR-3199_st 4.754752368 4.608359402 hsa-miR-3200_st 3.154084708 3.872455472 hsa-miR-3201_st 3.877606697 3.458973914 hsa-miR-514b-5p_st 9.874268622 9.500407674 hsa-miR-514b-3p_st 1.402356844 1.777999516 hsa-miR-3202_st 7.738810921 7.517156041 hsa-miR-1273d_st 11.60280398 11.35626331 hsa-miR-4295_st 1.931903283 2.132044697 hsa-miR-4296_st 7.275021063 6.644864124 hsa-miR-4297_st 5.343286852 5.422587806 hsa-miR-378c_st 8.420518509 8.562011567 hsa-miR-4293_st 4.242231179 4.368393525 hsa-miR-4294_st 7.650123448 7.374027486 hsa-miR-4301_st 2.228095075 2.133986309 hsa-miR-4299_st 12.53474584 12.73079626 hsa-miR-4298_st 13.00339819 12.74731493 hsa-miR-4300_st 7.580250098 7.088464462 hsa-miR-4304_st 5.967406714 5.875109351 hsa-miR-4302_st 5.276100863 5.236412449 hsa-miR-4303_st 5.807861351 6.002325091 hsa-miR-4305_st 3.61704062 3.376297467 hsa-miR-4306_st 9.43700333 9.385309266 hsa-miR-4309_st 3.43346671 3.560615807 hsa-miR-4307_st 2.384760497 2.711173548 hsa-miR-4308_st 1.416878319 2.010464942 hsa-miR-4310_st 3.052380358 3.628266963 hsa-miR-4311_st 4.892451406 4.608785295 hsa-miR-4312_st 6.472716919 6.127945376 hsa-miR-4313_st 5.69343871 5.40524793 hsa-miR-4315_st 2.677150824 3.115022119 hsa-miR-4316_st 7.507516492 7.101350428 hsa-miR-4314_st 8.52483982 8.259941138 hsa-miR-4318_st 3.024705032 2.975681662 hsa-miR-4319_st 3.396904748 3.216724224 hsa-miR-4320_st 2.743820827 2.628626923 hsa-miR-4317_st 8.854663529 9.049254113 hsa-miR-4322_st 12.59542136 11.92560502 hsa-miR-4321_st 10.11377839 9.267081291 hsa-miR-4323_st 5.591073958 5.409930688 hsa-miR-4324_st 7.0470127 7.291965127 hsa-miR-4256_st 3.867241681 3.602914193 hsa-miR-4257_st 12.13785011 11.66505888 hsa-miR-4258_st 7.676362685 7.131231992 hsa-miR-4259_st 11.0180055 10.48497079 hsa-miR-4260_st 10.45670775 10.14781802 hsa-miR-4253_st 11.25302284 10.58511018 hsa-miR-4251_st 5.764280017 5.633677603 hsa-miR-4254_st 5.380678028 5.336710632 hsa-miR-4255_st 2.649903696 2.629073433 hsa-miR-4252_st 4.691837687 4.634410546 hsa-miR-4325_st 2.879980251 3.145386356 hsa-miR-4326_st 4.777538434 4.784173474 hsa-miR-4327_st 12.09295135 11.45109662 hsa-miR-4261_st 8.362010242 8.394140492 hsa-miR-4265_st 7.336890943 7.191907851 hsa-miR-4266_st 6.149713022 5.478919472 hsa-miR-4267_st 5.505171634 5.506853671 hsa-miR-4262_st 1.430263669 1.580298001 hsa-miR-2355_st 2.090169511 2.401306329 hsa-miR-4268_st 3.823106966 3.571521985 hsa-miR-4269_st 7.704540144 7.526481382 hsa-miR-4263_st 2.251916983 2.668325453 hsa-miR-4264_st 2.158632979 2.333748508 hsa-miR-4270_st 15.40441472 14.90180799 hsa-miR-4271_st 11.64139121 11.19518471 hsa-miR-4272_st 1.39695707 1.230182865 hsa-miR-4273_st 1.051451991 1.180435309 hsa-miR-4276_st 1.051009386 1.326833075 hsa-miR-4275_st 1.871985847 1.739026976 hsa-miR-4274_st 5.629978633 5.400048437 hsa-miR-4281_st 15.80337411 15.28735574 hsa-miR-4277_st 2.395172897 2.321021436 hsa-miR-4279_st 5.633387454 4.741221052 hsa-miR-4278_st 6.858792003 6.223618133 hsa-miR-4280_st 4.156896034 4.29928346 hsa-miR-4282_st 0.017248915 0.171181809 hsa-miR-4285_st 11.80795524 11.15972937 hsa-miR-4283_st 8.706335149 7.951747816 hsa-miR-4284_st 14.76494449 15.07724784 hsa-miR-4286_st 13.79575921 14.1297145 hsa-miR-4287_st 4.730787189 5.059402816 hsa-miR-4288_st 3.914839643 4.932580056 hsa-miR-4292_st 7.176353439 6.781422755 hsa-miR-4289_st 5.477452762 6.232237948 hsa-miR-4290_st 6.705661946 6.023062657 hsa-miR-4291_st 5.570408916 6.484801604 hsa-miR-4329_st 5.828255767 5.705003789 hsa-miR-4330_st 5.504211012 5.122778314 hsa-miR-500b_st 3.851837359 4.171247331 hsa-miR-4328_st 2.880115886 3.102092043

TABLE 4D  normalized array data for the 55 benign and malignant FFPE samples  (all MiRNA are from Homo sapiens) LogRatio Se- SEQ (malignant  quence ID miRNA vs benign) Alignments Length Sequence NO hsa-let-7a_st −0.048023964 22 UGAGGUAGUAGGUUGUAUAGUU   65 hsa-let-7a-  0.217445459 21 CUAUACAAUCUACUGUCUUUC   66 star_st hsa-let-7a-2- −0.03760635 22 CUGUACAGCCUCCUAGCUUUCC   67 star_st hsa-let-7b_st  0.013698867 22:46509566-46509648 (+) 22 UGAGGUAGUAGGUUGUGUGGUU   68 hsa-let-7b- −0.748341751 22:46509566-46509648 (+) 22 CUAUACAACCUACUGCCUUCCC   69 star_st hsa-let-7c_st −0.071563315 21:17912148-17912231 (+) 22 UGAGGUAGUAGGUUGUAUGGUU   70 hsa-let-7c-  0.127967031 21:17912148-17932231 (+) 22 UAGAGUUACACCCUGGGAGUUA   71 star_st hsa-let-7d_st  0.083560357  9:96941116-96941202 (+) 22 AGAGGUAGUAGGUUGCAUAGUU   72 hsa-let-7d- −0.612452206  9:96941116-96941202 (+) 22 CUAUACGACCUGCUGCCUUUCU   73 star_st hsa-let-7e_st  0.2865631 19:52196039-52196117 (+) 22 UGAGGUAGGAGGUUGUAUAGUU   74 hsa-let-7e- −0.214645405 19:52196039-52196117 (+) 22 CUAUACGGCCUCCUAGCUUUCC   75 star_st hsa-let-7f_st  0.025135204 22 UGAGGUAGUAGAUUGUAUAGUU   76 hsa-let-7f-1- −0.298460339 22 CUAUACAAUCUAUUGCCUUCCC   77 star_st hsa-let-7f-2-  0.473970042 22 CUAUACAGUCUACUGUCUUUCC   78 star_st hsa-miR-15a_st  1.108769019 13:50623255-50623337 (−) 22 UAGCAGCACAUAAUGGUUUGUG   79 hsa-miR-15a-  0.167761859 13:50623255-50623337 (−) 22 CAGGCCAUAUUGUGCUGCCUCA   80 star_st hsa-miR-16_st  0.734813434 22 UAGCAGCACGUAAAUAUUGGCG   81 hsa-miR-16-1-  0.741299295 22 CCAGUAUUAACUGUGCUGCUGA   82 star_st hsa-miR-17_st  0.805305178 13:92002859-92002942 (+) 23 CAAAGUGCUUACAGUGCAGGUAG   83 hsa-miR-17-  0.414616826 13:92002859-92002942 (+) 22 ACUGCAGUGAAGGCACUUGUAG   84 star_st hsa-miR-18a_st  0.891730358 13:92003005-92003075 (+) 23 UAAGGUGCAUCUAGUGCAGAUAG   85 hsa-miR-18a-  0.089261898 13:92003005-92003075 (+) 23 ACUGCCCUAAGUGCUCCUUCUGG   86 star_st hsa-miR-19a- −0.152941809 13:92003145-92003226 (+) 22 AGUUUUGCAUAGUUGCACUACA   87 star_st hsa-miR-19a_st  0.694829137 13:92003145-92003226 (+) 23 UGUGCAAAUCUAUGCAAAACUGA   88 hsa-miR-19b-1-  0.170383606 23 AGUUUUGCAGGUUUGCAUCCAGC   89 star_st hsa-miR-19b_st  0.682682286 23 UGUGCAAAUCCAUGCAAAACUGA   90 hsa-miR-19b-2-  0.118943559 22 AGUUUUGCAGGUUUGCAUUUCA   91 star_st hsa-miR-20a_st  0.694990809 13:92003319-92003389 (+) 23 UAAAGUGCUUAUAGUGCAGGUAG   92 hsa-miR-20a- −0.249127844 13:92003319-92003389 (+) 22 ACUGCAUUAUGAGCACUUAAAG   93 star_st hsa-miR-21_st  2.173328901 17:57918627-57918698 (+) 22 UAGCUUAUCAGACUGAUGUUGA   94 hsa-miR-21-  0.913325389 17:57918627-57918698 (+) 21 CAACACCAGUCGAUGGGCUGU   95 star_st hsa-miR-22-  0.805013409 17:1617197-1617281 (−) 22 AGUUCUUCAGUGGCAAGCUUUA   96 star_st hsa-miR-22_st  0.497050849 17:16I7197-1617281 (−) 22 AAGCUGCCAGUUGAAGAACUGU   97 hsa-miR-23a- −0.40320726 19:13947401-13947473 (−) 22 GGGGUUCCUGGGGAUGGGAUUU   98 star_st hsa-miR-23a_st  0.598156224 19:13947401-13947473 (−) 21 AUCACAUUGCCAGGGAUUUCC   99 hsa-miR-24-1-  1.152267111 22 UGCCUACUGAGCUGAUAUCAGU  100 star_st hsa-miR-24_st  0.879752178 22 UGGCUCAGUUCAGCAGGAACAG  101 hsa-miR-24-2-  1.542735664 22 UGCCUACUGAGCUGAAACACAG  102 star_st hsa-miR-25- −0.649750992  7:99691183-99691266 (−) 21 AGGCGGAGACUUGGGCAAUUG  103 star_st hsa-miR-25_st  0.299753561  7:99691183-99691266 (−) 22 CAUUGCACUUGUCUCGGUCUGA  104 hsa-miR-26a_st −0.124819372 22 UUCAAGUAAUCCAGGAUAGGCU  105 hsa-miR-26a-1- −0.401191655 22 CCUAUUCUUGGUUACUUGCACG  106 star_st hsa-miR-26b_st  0.231155035  2:219267369-219267445 (+) 21 UUCAAGUAAUUCAGGAUAGGU  107 hsa-miR-26b-  0.215482208  2:219267369-219267445 (+) 22 CCUGUUCUCCAUUACUUGGCUC  108 star_st hsa-miR-27a-  0.320877233 19:13947254-13947331 (−) 22 AGGGCUUAGCUGCUUGUGAGCA  109 star_st hsa-miR-27a_st  1.309760051 19:13947254-13947331 (−) 21 UUCACAGUGGCUAAGUUCCGC  110 hsa-miR-28-  0.736552791  3:188406569-188406654 (+) 22 AAGGAGCUCACAGUCUAUUGAG  111 5p_st hsa-miR-28-  0.469314854  3:188406569-188406654 (+) 22 CACUAGAUUGUGAGCUCCUGGA  112 3p_st hsa-miR-29a-  0.266553866  7:130561506-130561569 (−) 22 ACUGAUUUCUUUUGGUGUUCAG  113 star_st hsa-miR-29a_st  0.741466995  7:130561506-130561569 (−) 22 UAGCACCAUCUGAAAUCGGUUA  114 hsa-miR-30a_st  0.080469489  6:72113254-72113324 (−) 22 UGUAAACAUCCUCGACUGGAAG  115 hsa-miR-30a- −1.10736252  6:72113254-72113324 (−) 22 CUUUCAGUCGGAUGUUUGCAGC  116 star_st hsa-miR-31_st  1.622439287  9:21512114-21512184 (−) 21 AGGCAAGAUGCUGGCAUAGCU  117 hsa-miR-31-  2.390305726  9:21512114-21512184 (−) 22 UGCUAUGCCAACAUAUUGCCAU  118 star_st hsa-miR-32_st  0.62671376  9:111808509-111808578 (−) 22 UAUUGCACAUUACUAAGUUGCA  119 hsa-miR-32- −0.194057854  9:111808509-111808578 (−) 22 CAAUUUAGUGUGUGUGAUAUUU  120 star_st hsa-miR-33a_st  0.313788559 22:42296948-42297016 (+) 21 GUGCAUUGUAGUUGCAUUGCA  121 hsa-miR-33a-  0.921600085 22:42296948-42297016 (+) 22 CAAUGUUUCCACAGUGCAUCAC  122 star_st hsa-miR-92a-1-  −0.581599889 23 AGGUUGGGAUCGGUUGCAAUGCU  123 star_st hsa-miR-92a_st  0.144284845 22 UAUUGCACUUGUCCCGGCCUGU  124 hsa-miR-92a-2- −0.597060048 22 GGGUGGGGAUUUGUUGCAUUAC  125 star_st hsa-miR-93_st  0.804315226  7:99691391-99691470 (−) 23 CAAAGUGCUGUUCGUGCAGGUAG  126 hsa-miR-93-  0.596630167  7:99691391-99691470 (−) 22 ACUGCUGAGCUAGCACUUCCCG  127 star_st hsa-miR-95_st −0.346953682  4:8007O28-8007108 (−) 22 UUCAACGGGUAUUUAUUGAGCA  128 hsa-miR-96_st  1.039744333  7:129414532-129414609 (−) 23 UUUGGCACUAGCACAUUUUUGCU  129 hsa-miR-96- −0.156917058  7:129414532-129414609 (−) 22 AAUCAUGUGCAGUGCCAAUAUG  130 star_st hsa-miR-98_st  0.922592035  X:53583184-53583302 (−) 22 UGAGGUAGUAAGUUGUAUUGUU  131 hsa-miR-99a_st  0.512778282 21:17911409-17911489 (+) 22 AACCCGUAGAUCCGAUCUUGUG  132 hsa-miR-99a-  0.881793689 21:17911409-17911489 (+) 22 CAAGCUCGCUUCUAUGGGUCUG  133 star_st hsa-miR-100_st  0.249572435 11:122022937-122023016 (−) 22 AACCCGUAGAUCCGAACUUGUG  134 hsa-miR-100- −0.271273201 11:122022937-122023016 (−) 22 CAAGCUUGUAUCUAUAGGUAUG  135 star_st hsa-miR-101-  0.365359575 22 CAGUUAUCACAGUGCUGAUGCU  136 star_st hsa-miR-101_st  0.821576153 21 UACAGUACUGUGAUAACUGAA  137 hsa-miR-29b-1-   0.465671107 24 GCUGGUUUCAUAUGGUGGUUUAGA  138 star_st hsa-miR-29b_st  0.950973534 23 UAGCACCAUUUGAAAUCAGUGUU  139 hsa-miR-29b-2-   0.072729757 22 CUGGUUUCACAUGGUGGCUUAG  140 star_st hsa-miR-103-2-   0.47954039 23 AGCUUCUUUACAGUGCUGCCUUG  141 star_st hsa-miR-103_st  0.492177895 23 AGCAGCAUUGUACAGGGCUAUGA  142 hsa-miR-105_st  0.012220407 23 UCAAAUGCUCAGACUCCUGUGGU  143 hsa-miR-105- −0.171838427 22 ACGGAUGUUUGAGCAUGUGCUA  144 star_st hsa-miR-106a_st  0.641800789  X:133304228-133304308 (−) 23 AAAAGUGCUUACAGUGCAGGUAG  145 hsa-miR-106a- −0.002080901  X:133309228-133304308 (−) 22 CUGCAAUGUAAGCACUUCUUAC  146 star_st hsa-miR-107_st  0.57762915 10:91352504-91352584 (−) 23 AGCAGCAUUGUACAGGGCUAUCA  147 hsa-miR-16-2-  0.890157867 22 CCAAUAUUACUGUGCUGCUUUA  148 star_st hsa-miR-192_st  0.593710572 11:64658609-64658718 (−) 21 CUGACCUAUGAAUUGACAGCC  149 hsa-miR-192-  0.219711485 11:64658609-64658718 (−) 22 CUGCCAAUUCCAUAGGUCACAG  150 star_st hsa-miR-196a_st  0.997020636 22 UAGGUAGUUUCAUGUUGUUGGG  151 hsa-miR-197_st −0.695426484  1:110141515-110141589 (+) 22 UUCACCACCUUCUCCACCCAGC  152 hsa-miR-198_st −0.374203131  3:120114515-120114576 (−) 22 GGUCCAGAGGGGAGAUAGGUUC  153 hsa-miR-199a-   0.924255382 23 CCCAGUGUUCAGACUACCUGUUC  154 5p_st hsa-miR-199a-  0.815769594 22 ACAGUAGUCUGCACAUUGGUUA  155 3p_st hsa-miR-208a_st  0.43995374 14:23857805-23857875 (−) 22 AUAAGACGAGCAAAAAGCUUGU  156 hsa-miR-129- −0.640994824 21 CUUUUUGCGGUCUGGGCUUGC  157 5p_st hsa-miR-129-  0.229379183 22 AAGCCCUUACCCCAAAAAGUAU  158 star_st hsa-miR-148a-  0.244582293  7:25989539-25989606 (−) 22 AAAGUUCUGAGACACUCCGACU  159 star_st hsa-miR-148a_st  0.823898116  7:25989539-25989606 (−) 22 UCAGUGCACUACAGAACUUUGU  160 hsa-miR-30c_st −0.222005041 23 UGUAAACAUCCUACACUCUCAGC  161 hsa-miR-30c-2- −0.403215672 22 CUGGGAGAAGGCUGUUUACUCU  162 star_st hsa-miR-30d_st  0.367431688  8:135817119-135817188 (−) 22 UGUAAACAUCCCCGACUGGAAG  163 hsa-miR-30d-  0.274085418  8:135817119-135817188 (−) 22 CUUUCAGUCAGAUGUUUGCUGC  164 star_st hsa-miR-139- −1.091859388 11:72326107-72326174 (−) 22 UCUACAGUGCACGUGUCUCCAG  165 5p_st hsa-miR-139- −0.547607554 11:72326107-72326174 (−) 22 GGAGACGCGGCCCUGUUGGAGU  166 3p_st hsa-miR-147_st −0.258983494  9:123007257-123007328 (−) 20 GUGUGUGGAAAUGCUUCUGC  167 hsa-miR-7_st −2.160993031 23 UGGAAGACUAGUGAUUUUGUUGU  168 hsa-miR-7-1-  0.390819845 22 CAACAAAUCACAGUCUGCCAUA  169 star_st hsa-miR-7-2- −0.891725706 22 CAACAAAUCCCAGUCUACCUAA  170 star_st hsa-miR-10a_st  0.760462994 17:46657200-46657309 (−)  23 UACCCUGUAGAUCCGAAUUUGUG  171 hsa-miR-10a-  0.187536432 17:46657200-46657309 (−) 22 CAAAUUCGUAUCUAGGGGAAUA  172 star_st hsa-miR-10b_st  1.192856815  2:177015031-177015140 (+) 23 UACCCUGUAGAACCGAAUUUGUG  173 hsa-miR-10b-  0.27457053  2:177015031-177015140 (+) 22 ACAGAUUCGAUUCUAGGGGAAU  174 star_st hsa-miR-34a_st  1.644540443  1:9211727-9211836 (−) 22 UGGCAGUGUCUUAGCUGGUUGU  175 hsa-miR-34a-  1.510148362  1:9211727-9211836 (−) 22 CAAUCAGCAAGUAUACUGCCCU  176 star_st hsa-miR-181a_st  0.493363018 23 AACAUUCAACGCUGUCGGUGAGU  177 hsa-miR-181a-2-  1.02626003 22 ACCACUGACCGUUGACUGUACC  178 star_st hsa-miR-181b_st  0.527375559 23 AACAUUCAUUGCUGUCGGUGGGU  179 hsa-miR-181c_st  1.011868821 19:13985513-13985622 (+) 22 AACAUUCAACCUGUCGGUGAGU  180 hsa-miR-181c-  0.59869708 19:13985513-13985622 (+) 22 AAACCAUCGACCGUUGAGUGGAC  181 star_st hsa-miR-182_st  1.262246153  7:129410223-129410332 (−) 24 UUUGGCAAUGGUAGAACUCACACU  182 hsa-miR-182- −0.343312162  7:129410223-129410332 (−) 21 UGGUUCUAGACUUGCCAACUA  183 star_st hsa-miR-183_st  0.630655391  7:129414745-129414854 (−) 22 UAUGGCACUGGUAGAAUUCACU  184 hsa-miR-183- −0.13345253  7:129414745-129414854 (−) 22 GUGAAUUACCGAAGGGCCAUAA  185 star_st hsa-miR-187- −0.490744534 18:33484781-33484889 (−) 22 GGCUACAACACAGGACCCGGGC  186 star_st hsa-miR-187_st  0.28384338 18:33484781-33484889 (−) 22 UCGUGUCUUGUGUUGCAGCCGG  187 hsa-miR-196a-  0.574631487 22 CGGCAACAAGAAACUGCCUGAG  188 star_st hsa-miR-199b-  0.931725352  9:131007000-131007109 (−) 23 CCCAGUGUUUAGACUAUCUGUUC  189 5p_st hsa-miR-199b-  1.008638211  9:131007000-131007109 (−) 22 ACAGUAGUCUGCACAUUGGUUA  190 3p_st hsa-miR-203_st  0.035466475 14:104583742-104583851 (+) 22 GUGAAAUGUUUAGGACCACUAG  191 hsa-miR-204_st −1.642891797  9:73424891-73425000 (−) 22 UUCCCUUUGUCAUCCUAUGCCU  192 hsa-miR-205_st  0.365322787  1:209605478-209605587 (+) 22 UCCUUCAUUCCACCGGAGUCUG  193 hsa-miR-205- −0.100505489  1:209605478-209605587 (+) 21 GAUUUCAGUGGAGUGAAGUUC  194 star_st hsa-miR-210_st −0.426055268 11:568089-568198 (−) 22 CUGUGCGUGUGACAGCGGCUGA  195 hsa-miR-211_st −0.207934914 15:31357235-31357344 (−) 22 UUCCCUUUGUCAUCCUUCGCCU  196 hsa-miR-212_st  0.387277691 17:1953565-1953674 (−) 21 UAACAGUCUCCAGUCACGGCC  197 hsa-miR-181a-  1.217432668 22 ACCAUCGACCGUUGAUUGUACC  198 star_st hsa-miR-214-  0.664208274  1:172107938-172108047 (−) 22 UGCCUGUCUACACUUGCUGUGC  199 star_st hsa-miR-214_st −0.192700009  1:172107938-172108047 (−) 22 ACAGCAGGCACAGACAGGCAGU  200 hsa-miR-215_st  0.760307473  1:220291195-220291304 (−) 21 AUGACCUAUGAAUUGACAGAC  201 hsa-miR7216a_st  0.208935083  2:56216085-56216194 (−) 22 UAAUCUCAGCUGGCAACUGUGA  202 hsa-miR-217_st  0.295493985  2:56210102-56210211 (−) 23 UACUGCAUCAGGAACUGAUUGGA  203 hsa-miR-218_st  1.215558827 21 UUGUGCUUGAUCUAACCAUGU  204 hsa-miR-218-1- −0.402759664 22 AUGGUUCCGUCAAGCACCAUGG  205 star_st hsa-miR-218-2- −0.349252359 22 CAUGGUUCUGUCAAGCACCGCG  206 star_st hsa-miR-219-  0.023609757 21 UGAUUGUCCAAACGCAAUUCU  207 5p_st hsa-miR-219-1-  0.252378496  6:33175612-33175721 (+) 22 AGAGUUGAGUCUGGACGUCCCG  208 3p_st hsa-miR-220a_st  0.112818758  X:122695946-122696055 (−) 21 CCACACCGUAUCUGACACUUU  209 hsa-miR-221-  2.715957711  X:45605585-45605694 (−) 22 ACCUGGCAUACAAUGUAGAUUU  210 star_st hsa-miR-221_st  1.897354614  X:45605585-45605694 (−) 23 AGCUACAUUGUCUGCUGGGUUUC  211 hsa-miR-222-  0.805099621  X:45606421-45606530 (−) 22 CUCAGUAGCCAGUGUAGAUCCU  212 star_st hsa-miR-222_st  1.96393452  X:45606421-45606530 (−) 21 AGCUACAUCUGGCUACUGGGU  213 hsa-miR-223-  0.532413464  X:65238712-65238821 (+) 22 CGUGUAUUUGACAAGCUGAGUU  214 star_st hsa-miR-223_st  0.624421002  X:65238712-65238821 (+) 22 UGUCAGUUUGUCAAAUACCCCA  215 hsa-miR-224_st  0.990921161  X:151127050-151127130 (−) 21 CAAGUCACUAGUGGUUCCGUU  216 hsa-miR-224-  0.31235436  X:151127050-151127130 (−) 23 AAAAUGGUGCCCUAGUGACUACA  217 star_st hsa-miR-200b- −0.404959657  1:1102484-1102578 (+) 22 CAUCUUACUGGGCAGCAUUGGA  218 star_st hsa-miR-200b_st  0.17647889  1:1102484-1102578 (+) 22 UAAUACUGCCUGGUAAUGAUGA  219 hsa-let-7g_st  0.180746211  3:52302294-52302377 (−) 22 UGAGGUAGUAGUUUGUACAGUU  220 hsa-let-7g- −0.360572088  3:52302294-52302377 (−) 21 CUGUACAGGCCACUGCCUUGC  221 star_st hsa-10-7i_st  0.416034157 12:62997466-62997549 (+) 22 UGAGGUAGUAGUUUGUGCUGUU  222 hsa-14-7i-  0.388065899 12:62997466-62997549 (+) 22 CUGCGCAAGCUACUGCCUUGCU  223 star_st hsa-miR-1_st  0.061353305 22 UGGAAUGUAAAGAAGUAUGUAU  224 hsa-miR-15b_st −0.003846858  3:160122376-160122473 (+) 22 UAGCAGCACAUCAUGGUUUACA  225 hsa-miR-15b- −0.526285658  3:160122376-160122473 (+) 22 CGAAUCAUUAUUUGCUGCUCUA  226 star_st hsa-miR-23b- −0.045511684  9:97847490-97847586 (+) 22 UGGGUUCCUGGCAUGCUGAUUU  227 star_st hsa-miR-23b_st  0.453860873  9:97847490-97847586 (+) 21 AUCACAUUGCCAGGGAUUACC  228 hsa-miR-27b-  0.988333417  9:97847727-97847823 (+) 22 AGAGCUUAGCUGAUUGGUGAAC  229 star_st hsa-miR-27b_st  0.944920392  9:97847727-97847823 (+) 21 UUCACAGUGGCUAAGUUCUGC  230 hsa-miR-30b_st  0.400951157  8:135812763-135812850 (−) 22 UGUAAACAUCCUACACUCAGCU  231 hsa-miR-30b- −0.446186417  8:135812763-135812850 (−) 22 CUGGGAGGUGGAUGUUUACUUC  232 star_st hsa-miR-122_st −0.528270521 18:56118306-56118390 (+) 22 UGGAGUGUGACAAUGGUGUUUG  233 hsa-miR-122-  0.218095686 18:56118306-56118390 (+) 22 AACGCCAUUAUCACACUAAAUA  234 star_st hsa-miR-124- −0.098340343 22 CGUGUUCACAGCGGACCUUGAU  235 star_st hsa-miR-124_st −0.171384948 20 UAAGGCACGCGGUGAAUGCC  236 hsa-miR-125b_st  0.07339278 22 UCCCUGAGACCCUAACUUGUGA  237 hsa-miR-125b-1- −0.44737633 22 ACGGGUUAGGCUCUUGGGAGCU  238 star_st hsa-miR-128_st  0.375130151 21 UCACAGUGAACCGGUCUCUUU  239 hsa-miR-130a- −0.075902575 11:57408671-57408759 (+) 22 UUCACAUUGUGCUACUGUCUGC  240 star_st hsa-miR-130a_st  0.118023189 11:57408671-57408159 (+) 22 CAGUGCAAUGUUAAAAGGGCAU  241 hsa-miR-132-  0.996501258 17:1953202-1953302 (−) 22 ACCGUGGCUUUCGAUUGUUACU  242 star_st hsa-miR-132_st  1.065793699 17:1953202-1953302 (−) 22 UAACAGUCUACAGCCAUGGUCG  243 hsa-miR-133a_st −0.425346456 22 UUUGGUCCCCUUCAACCAGCUG  244 hsa-miR-135a_st  1.06098116 23 UAUGGCUUUUUAUUCCUAUGUGA  245 hsa-miR-135a- −0.505118465 22 UAUAGGGAUUGGAGCCGUGGCG  246 star_st hsa-miR-137_st  0.237080977  1:98511626-98511727 (−) 23 UUAUUGCUUAAGAAUACGCGUAG  247 hsa-miR-138_st −0.960265771 23 AGCUGGUGUUGUGAAUCAGGCCG  248 hsa-miR-138-2-  0.256034416 22 GCUAUUUCACGACACCAGGGUU  249 star_st hsa-miR-140-  1.130300163 16:69966984-69967083 (+) 22 CAGUGGUUUUACCCUAUGGUAG  250 5p_st hsa-miR-140-  0.223036719 16:69966984-69967083 (+) 21 UACCACAGGGUAGAACCACGG  251 3p_st hsa-miR-141- −0.008343285 12:7073260-7073354 (+) 22 CAUCUUCCAGUACAGUGUUGGA  252 star_st hsa-miR-141_st  0.450479229 12:7073260-7073354 (+) 22 UAACACUGUCUGGUAAAGAUGG  253 hsa-miR-142-  1.353572052 17:56408593-56408679 (−) 21 CAUAAAGUAGAAAGCACUACU  254 5p_st hsa-miR-142-  0.246580674 17:56408593-56408679 (−) 23 UGUAGUGUUUCCUACUUUAUGGA  255 3p_st hsa-miR-143- −0.064880327  5:148808481-148808586 (+) 22 GGUGCAGUGCUGCAUCUCUGGU  256 star_st hsa-miR-143_st  0.245792956  5:148808481-148808386 (+) 21 UGAGAUGAAGCACUGUAGCUC  257 hsa-miR-144-  0.02638293 17:27188551-27188636 (−) 22 GGAUAUCAUCAUAUACUGUAAG  258 star_st hsa-miR-144_st −0.474283509 17:27188551-27188636 (−) 20 UACAGUAUAGAUGAUGUACU  259 hsa-miR-145_st −0.331497872  5:148810209-148810296 (+) 23 GUCCAGUUUUCCCAGGAAUCCCU  260 hsa-miR-145-  0.289009546  5:148810209-148810296 (+) 22 GGAUUCCUGGAAAUACUGUUCU  261 star_st hsa-miR-152_st −0.132107943 17:46114527-46114613 (−) 21 UCAGUGCAUGACAGAACUUGG  262 hsa-miR-153_st  0.206204323 22 UUGCAUAGUCACAAAAGUGAUC  263 hsa-miR-191_st  0.527445159  3:49058051-49038142 (−) 23 CAACGGAAUCCCAAAAGCAGCUG  264 hsa-miR-191- −0.177276096  3:49058051-49058142 (−) 22 GCUGCGCUUGGAUUUCGUCCC  265 star_st hsa-miR-9_st  0.361062989 23 UCUUUGGUUAUCUAGCUGUAUGA  266 hsa-miR-9-  0.129542783 22 AUAAAGCUAGAUAACCGAAAGU  267 star_st hsa-miR-125a-  0.027803044 19:52196507-52196592 (+) 24 UCCCUGAGACCCUUUAACCUGUGA  268 5p_st hsa-miR-125a- −0.356803841 19:52196507-52196592 (+) 22 ACAGGUGAGGUUCUUGGGAGCC  269 3p_st hsa-miR-125b- −0.201602688 22 UCACAAGUCAGGCUCUUGGGAC  270 2-star_st hsa-miR-126-  0.576116104  9:139565054-139363138 (+) 21 CAUUAUUACUUUUGGUACGCG  271 star_st hsa-miR-126_st −0.007129146  9:139565054-139565138 (+) 22 UCGUACCGUGAGUAAUAAUGCG  272 hsa-miR-127-  0.43991996 14:101349316-101349412 (+) 22 CUGAAGCUCAGAGGGCUCUGAU  273 5p_st hsa-miR-127-  0.539861029 14:101349316-101349412 (+) 22 UCGGAUCCGUCUGAGCUUGGCU  274 3p_st hsa-miR-129-  0.651300542 22 AAGCCCUUACCCCAAAAAGGAU  275 3p_st hsa-miR-134_st −0.263214268 14:101521024-101521096 (+) 22 UGUGACUGGUUGACCAGAGGGG  276 hsa-miR-136_st  0.314078184 14:101351039-101351120 (+) 23 ACUCCAUUUGUUUUGAUGAUGGA  277 hsa-miR-136-  0.458516901 14:101351039-101351120 (+) 22 CAUCAUCGUCUCAAAUGAGUCU  278 star_st hsa-miR-138-1- −0.910488475 22 GCUACUUCACAACACCAGGGCC  279 star_st hsa-miR-146a_st  1.489357674  5:159912359-159912457 (+) 22 UGAGAACUGAAUUCCAUGGGUU  280 hsa-miR-146a-  0.839196309  5:159912359-159912457 (+) 22 CCUCUGAAAUUCAGUUCUUCAG  281 star_st hsa-miR-149_st  0.262228024  2:241395418-241395506 (+) 23 UCUGGCUCCGUGUCUUCACUCCC  282 hsa-miR-149- −0.494806596  2:241395418-241195506 (+) 21 AGGGAGGGACGGGGGCUGUGC  283 star_st hsa-miR-150_st −0.136159708 19:50004042-50004125 (−) 22 UCUCCCAACCCUUGUACCAGUG  284 hsa-miR-150- −0.349080262 19:50004042-50004125 (−) 22 CUGGUACAGGCCUGGGGGACAG  285 star_st hsa-miR-154_st −0.037793351 14:101526092-101526175 (+) 22 UAGGUUAUCCGUGUUGCCUUCG  286 hsa-miR-154- −0.212570871 14:101526092-101526175 (+) 22 AAUCAUACACGGUUGACCUAUU  287 star_st hsa-miR-184_st −0.408453827 15:19502130-79502213 (+) 22 UGGACGGAGAACUGAUAAGGGU  288 hsa-miR-185_st −0.11768006 22:20020662-20020743 (+) 22 UGGAGAGAAAGGCAGUUCCUGA  289 hsa-miR-185- −0.973967372 22:20020662-20020743 (+) 22 AGGGGCUGGCUUUCCUCUGGUC  290 star_st hsa-miR-186_st −0.167692325  1:71533314-71533399 (−) 22 CAAAGAAUUCUCCUUUUGGGCU  291 hsa-miR-186-  0.75235132  1:71533314-71533399 (−) 22 GCCCAAAGGUGAAUUUUUUGGG  292 star_st hsa-miR-188-  0.153429662  X:49768109-49768194 (+) 21 CAUCCCUUGCAUGGUGGAGGG  293 5p_st hsa-miR-188-  0.134349045  X:49768109-49768194 (+) 21 CUCCACAUGCAGGGUUUGCA  294 3p_st hsa-miR-190_st −0.24523743 15:63116156-63116240 (+) 22 UGAUAUGUUUGAUAUAUUAGGU  295 hsa-miR-193a- −0.833145932 17:29887015-29887102 (+) 22 UGGGUCUUUGCGGGCGAGAUGA  296 5p_st hsa-miR-193a-  0.238877874 17:29887015-29887102 (+) 22 AACUGGCCUACAAAGUCCCAGU  297 3p_st hsa-miR-194_st  0.379322206 22 UGUAACAGCAACUCCAUGUGGA  298 hsa-miR-195_st  0.344977836 17:6920934-6921020 (−) 21 UAGCAGCACAGAAAUAUUGGC  299 hsa-miR-195-  0.40065597 17:6920934-6921020 (−) 22 CCAAUAUUGGCUGUGCUGCUCC  300 star_st hsa-miR-206_st  0.08440626  6:52009147-52009232 (+) 22 UGGAAUGUAAGGAAGUGUGUGG  301 hsa-miR-320a_st −0.306150576  8:22102475-22102556 (−) 22 AAAAGCUGGGUUGAGAGGGCGA  302 hsa-miR-200c- −0.052932563 12:7072862-1072929 (+) 22 CGUCUUACCCAGCAGUGUUUGG  303 star_st hsa-miR-200c_st −0.239821076 12:7072862-7072929 (+) 23 UAAUACUGCCGGGUAAUGAUGGA  304 hsa-miR-155_st  0.608153889 21:26946292-26946356 (+) 23 UUAAUGCUAAUCGUGAUAGGGGU  305 hsa-miR-155-  0.056816503 21:26946292-26946356 (+) 22 CUCCUACAUAUUAGCAUUAACA  306 star_st hsa-miR-194- −0.515277592 22 CCAGUGGGGCUGCUGUUAUCUG  307 star_st hsa-miR-106b_st  0.896125094  7:99691616-99691697 (−) 21 UAAAGUGCUGACAGUGCAGAU  308 hsa-miR-106b-  0.137425123  7:99691616-99691697 (−) 22 CCGCACUGUGGGUACUUGCUGC  309 star_st hsa-miR-29c-  0.140772995  1:207975197-207975284 (−) 22 UGACCGAUUUCUCCUGGUGUUC  310 star_st hsa-miR-29c_st  0.436946695  1:207975197-207975284 (−) 22 UAGCACCAUUUGAAAUCGGUUA  311 hsa-miR-30c-1- −0.049900136 22 CUGGGAGAGGGUUGUUUACUCC  312 star_st hsa-miR-200a-  0.257167734  1:1103243-1103332 (+) 22 CAUCUUACCGGACAGUGCUGGA  313 star_st hsa-miR-200a_st  0.334093033  1:1103243-1103332 (+) 22 UAACACUGUCUGGUAACGAUGU  314 hsa-miR-302a- −0.001562424  4:113569339-113569407 (−) 23 ACUUAAACGUGGAUGUACUUGCU  315 star_st hsa-miR-302a_st  0.182673435  4:113569339-113569407 (−) 23 UAAGUGCUUCCAUGUUUUGGUGA  316 hsa-miR-219-2-  0.008465241  9:131154897-131154993 (−) 22 AGAAUUGUGGCUGGACAUCUGU  317 3p_st hsa-miR-34b-  1.378749354 11:111383663-111383746 (+) 23 UAGGCAGUGUCAUUAGCUGAUUG  318 star_st hsa-miR-34b_st −0.604360179 11:111383663-111383746 (+) 22 CAAUCACUAACUCCACUGCCAU  319 hsa-miR-34c-  0.588298823 11:111384164-111384240 (+) 23 AGGCAGUGUAGUUAGCUGAUUGC  320 5p_st hsa-miR-34c- −0.181566213 11:111384164-111384240 (+) 22 AAUCACUAACCACACGGCCAGG  321 3p_st hsa-miR-299- −0.15952566 14:101490131-101490193 (+) 22 UGGUUUACCGUCCCACAUACAU  322 5p_st hsa-miR-299- −0.134298858 14:101490131-101490193 (+) 22 UAUGUGGGAUGGUAAACCGCUU  323 3p_st hsa-miR-301a_st  1.480810077 17:57228497-57228582 (−) 23 CAGUGCAAUAGUAUUGUCAAAGC  324 hsa-miR-99b_st  0.445102969 19:52195865-52195934 (+) 22 CACCCGUAGAACCGACCUUGCG  325 hsa-miR-99b- −0.256000929 19:52195865-52195934 (+) 22 CAAGCUCGUGUCUGUGGGUCCG  326 star_st hsa-miR-296-  0.331136889 20:57392670-57392749 (−) 21 AGGGCCCCCCCUCAAUCCUGU  327 5p_st hsa-miR-296- −0.484459617 20:57392670-57392749 (−) 22 GAGGGUUGGGUGGAGGCUCUCC  328 3p_st hsa-miR-130b- −0.428478249 22:22007593-22007674 (+) 21 ACUCUUUCCCUGUUGCACUAC  329 star_st hsa-miR-130b_st  0.276541886 22:22007593-22007674 (+) 22 CAGUGCAAUGAUGAAAGGGCAU  330 hsa-miR-30c_st  0.367656808  1:41220027-41220118 (+) 22 UGUAAACAUCCUUGACUGGAAG  331 hsa-miR-30c- −0.524125402  1:41220027-41220118 (+) 22 CUUUCAGUCGGAUGUUUACAGC  332 star_st hsa-miR-26a-2-  0.43879887 22 CCUAUUCUUGAUUACUUGUUUC  333 star_st hsa-miR-361-  0.185895719  X:85158641-85158712 (−) 22 UUAUCAGAAUCUCCAGGGGUAC  334 5p_st hsa-miR-361-  0.280893435  X:85158641-85158712 (−) 23 UCCCCCAGGUGUGAUUCUGAUUU  335 3p_st hsa-miR-362-  0.289322897  X:49773572-49773636 (+) 24 AAUCCUUGGAACCUAGGUGUGAGU  336 5p_st hsa-miR-362-  0.932533015  X:49773572-49773636 (+) 22 AACACACCUAUUCAAGGAUUCA  337 3p_st hsa-miR-363- −0.421094689  X:133303408-133303482 (−) 22 CGGGUGGAUCACGAUGCAAUUU  338 star_st hsa-miR-363_st  0.57250165  X:133303408-133303482 (−) 22 AAUUGCACGGUAUCCAUCUGUA  339 hsa-miR-365_st −0.083976508 22 UAAUGCCCCUAAAAAUCCUUAU  340 hsa-miR-365- −0.543569131 22 AGGGACUUUCAGGGGCAGCUGU  341 star_st hsa-miR-302b- −0.079212528  4:113569641-113569713 (−) 22 ACUUUAACAUGGAAGUGCUUUC  342 star_st hsa-miR-302b_st  0.802790198  4:113569641-113569713 (−) 23 UAAGUGCUUCCAUGUUUUAGUAG  343 hsa-miR-302c- −0.544478956  4:113569519-113569586 (−) 22 UUUAACAUGGGGGUACCUGCUG  344 star_st hsa-miR-302c_st  0.501592778  4:113569519-113569586 (−) 23 UAAGUGCUUCCAUGUUUCAGUGG  345 hsa-miR-302d- −0.103409044  4:113569160-113569227 (−) 22 ACUUUAACAUGGAGGCACUUGC  346 star_st hsa-miR-302d_st  0.48017505  4:113569160-113569227 (−) 23 UAAGUGCUUCCAUGUUUGAGUGU  347 hsa-miR-367- −0.000436563  4:113569030-113569097 (−) 22 ACUGUUGCUAAUAUGCAACUCU  348 star_st hsa-miR-367_st −0.023708527  4:113569030-113569097 (−) 22 AAUUGCACUUUAGCAAUGGUGA  349 hsa-miR-376c_st  1.223654497 14:101506027-101506092 (+) 21 AACAUAGAGGAAAUUCCACGU  350 hsa-miR-369-  0.853092711 14:101531935-101532004 (+) 22 AGAUCGACCGUGUUAUAUUCGC  351 5p_st hsa-miR-369- −0.381025345 14:101531935-101532004 (+) 21 AAUAAUACAUGGUUGAUCUUU  352 3p_st hsa-miR-370_st −0.485633939 14:101377476-101377550 (+) 22 GCCUGCUGGGGUGGAACCUGGU  353 hsa-miR-371- −0.699590356 19:54290929-54290995 (+) 20 ACUCAAACUGUGGGGGCACU  354 5p_st hsa-miR-371- −0.767486246 19:54290929-54290995 (+) 23 AAGUGCCGCCAUCUUUUGAGUGU  355 3p_st hsa-miR-372_st −0.018614281 19:54291144-54291210 (+) 23 AAAGUGCUGCGACAUUUGAGCGU  356 hsa-miR-373- −0.91382708 19:54291959-54292027 (+) 22 ACUCAAAAUGGGGGCGCUUUCC  357 star_st hsa-miR-373_st  0.061600195 19:54291959-54292027 (+) 23 GAAGUGCUUCGAUUUUGGGGUGU  358 hsa-miR-374a_st  0.500957184  X:73507121-73507192 (−) 22 UUAUAAUACAACCUGAUAAGUG  359 hsa-miR-374- −0.007451471  X:73507121-73507192 (−) 22 CUUAUCAGAUUGUAUUGUAAUU  360 star_st hsa-miR-375_st  2.428793377  2:219866367-219866430 (−) 22 UUUGUUCGUUCGGCUCGCGUGA  361 hsa-miR-376a- −0.114680818 22 GUAGAUUCUCCUUCUAUGAGUA  362 star_st hsa-miR-376a_st  0.657126002 21 AUCAUAGAGGAAAAUCCACGU  363 hsa-miR-377-  0.133361438 14:101528387-101528455 (+) 22 AGAGGUUGCCCUUGGUGAAUUC  364 star_st hsa-miR-377_st  0.547689033 14:101528387-101528455 (+) 22 AUCACACAAAGGCAACUUUUGU  365 hsa-miR-378- −0.137066823  5:149112388-149112453 (+) 22 CUCCUGACUCCAGGUCCUGUGU  366 star_st hsa-miR-378_st  0.112811797  5:149112388-149112453 (+) 21 ACUGGACUUGGAGUCAGAAGG  367 hsa-miR-379_st  0.292361055 14:101488403-101488469 (+) 21 UGGUAGACUAUGGAACGUAGG  368 hsa-miR-379- −0.299060613 14:101488403-101488469 (+) 22 UAUGUAACAUGGUCCACUAACU  369 star_st hsa-miR-380- −0.260339983 14:101491354-101491414 (+) 22 UGGUUGACCAUAGAACAUGCGC  370 star_st hsa-miR-380_st −0.434704478 14:101491354-101491414 (+) 22 UAUGUAAUAUGGUCCACAUCUU  371 hsa-miR-381_st   0.245912087 14:101512257-101512331 (+) 22 UAUACAAGGGCAAGCUCUCUGU  372 hsa-miR-382_st  0.065303359 14:101520643-101520718 (+) 22 GAAGUUGUUCGUGGUGGAUUCG  373 hsa-miR-383_st −0.117482093  8:14710947-14711019 (−) 22 AGAUCAGAAGGUGAUUGUGGCU  374 hsa-miR-340_st   1.486610867  5:179442303-179442397 (−) 22 UUAUAAAGCAAUGAGACUGAUU  375 hsa-miR-340-  0.374825831  5:179442303-179442397 (−) 22 UCCGUCUCAGUUACUUUAUAGC  376 star_st hsa-miR-330-  0.16929264 19:46142252-46142345 (−) 22 UCUCUGGGCCUGUGUCUUAGGC  377 5p_st hsa-miR-330-  0.251884038 19:46142252-46142345 (−) 23 GCAAAGCACACGGCCUGCAGAGA  378 3p_st hsa-miR-328_st −0.545026259 16:67236224-67236298 (−) 22 CUGGCCCUCUCUGCCCUUCCGU  379 hsa-miR-342- −0.082156952 14:100575992-100576090 (+) 21 AGGGGUGCUAUCUGUGAUUGA  380 5p_st hsa-miR-342-  0.565853501 14:100575992-100576090 (+) 23 UCUCACACAGAAAUCGCACCCGU  381 3p_st hsa-miR-337-  0.042107983 14:101340830-101340922 (+) 21 GAACGGCUUCAUACAGGAGUU  382 5p_st hsa-miR-337-  0.158376642 14:101340830-101340922 (+) 22 CUCCUAUAUGAUGCCUUUCUUC  383 3p_st hsa-miR-323- −0.511193887 14:101492069-101492154 (+) 22 AGGUGGUCCGUGGCGCGUUCGC  384 5p_st hsa-miR-323-  0.620363762 14:101492069-101492154 (+) 21 CACAUUACACGGUCGACCUCU  385 3p_st hsa-miR-326_st −0.405799761 11:75046136-75046230 (−) 20 CCUCUGGGCCCUUCCUCCAG  386 hsa-miR-151-  0.398889432  8:141742663-141742732 (−) 21 UCGAGGAGCUCACAGUCUAGU  387 5p_st hsa-miR-151-  0.774618536  8:141742663-141742752 (−) 21 CUAGACUGAAGCUCCUUGAGG  388 3p_st hsa-miR-135b_st  0.732231129  1:205417430-205417526 (−) 23 UAUGGCUUUUCAUUCCUAUGUGA  389 hsa-miR-135b-  0.014973154  1:205417430-205417526 (−) 22 AUGUAGGGCUAAAAGCCAUGGG  390 star_st hsa-miR-148b-  0.420399734 12:54731000-54731098 (+) 22 AAGUUCUGUUAUACACUCAGGC  391 star_st hsa-miR-148b_st  0.284484042 12:54731000-54731098 (+) 22 UCAGUGCAUCACAGAACUUUGU  392 hsa-miR-331-  0.296569348 12:95702196-95702289 (+) 22 CUAGGUAUGGUCCCAGGGAUCC  393 5p_st hsa-miR-331-  0.422330212 12:95702196-95702289 (+) 21 GCCCCUGGGCCUAUCCUAGAA  394 3p_st hsa-miR-324-  0.572325136 17:1126616-7126698 (−) 23 CGCAUCCCCUAGGGCAUUGGUGU  395 5p_st hsa-miR-324- −0.000611543 17:7126616-7126698 (−) 20 ACUGCCCCAGGUGCUGCUGG  396 3p_st hsa-miR-338-  0.933765272 17:79099683-79099749 (−) 22 AACAAUAUCCUGGUGCUGAGUG  397 5p_st hsa-miR-338-  0.921533511 17:79099683-79099749 (−) 22 UCCAGCAUCAGUGAUUUUGUUG  398 3p_st hsa-miR-339-  0.128816497  7:1062569-1062662 (−) 23 UCCCUGUCCUCCAGGAGCUCACG  399 5p_st hsa-miR-339-  0.096359142  7:1062569-1062662 (−) 23 UGAGCGCCUCGACGACAGAGCCG  400 3p_st hsa-miR-335_st  1.288082885  7:130135952-130136045 (+) 23 UCAAGAGCAAUAACGAAAAAUGU  401 hsa-miR-335-   0.2421496  7:130135952-130136045 (+) 22 UUUUUCAUUAUUGCUCCUGACC  402 star_st hsa-miR-133b_st −0.444246115  6:52013721-52013839 (+) 22 UUUGGUCCCCUUCAACCAGCUA  403 hsa-miR-325_st  0.13184687  X:76225829-76225926 (−) 23 CCUAGUAGGUGUCCAGUAAGUGU  404 hsa-miR-345_st −0.37213779 14:100774196-100774293 (+) 22 GCUGACUCCUAGUCCAGGGCUC  405 hsa-miR-346_st −0.737055304 10:88024451-88024545 (−) 23 UGUCUGCCCGCAUGCCUGCCUCU  406 hsa-miR-384_st  0.043552522  X:76139698-76139785 (−) 20 AUUCCUAGAAAUUGUUCAUA  407 hsa-miR-196b_st  0.246365454  7:27209099-27209182 (−) 22 UAGGUAGUUUCCUGUUGUUGGG  408 hsa-miR-196b- −0.01514933  7:27209099-27209182 (−) 22 UCGACAGCACGACACUGCCUUC  409 star_st hsa-miR-422a_st −0.18621341 15:64163129-64163218 (+) 22 ACUGGACUUAGGGUCAGAAGGC  410 hsa-miR-423- −0.448953283 17:28444097-28444190 (+) 23 UGAGGGGCAGAGAGCGAGACUUU  411 5p_st hsa-miR-423-  0.070589781 17:28444097-28444190 (+) 23 AGCUCGGUCUGAGGCCCCUCAGU  412 3p_st hsa-miR-424_st  1.385148397  X:133680644-133680741 (−) 22 CAGCAGCAAUUCAUGUUUUGAA  413 hsa-miR-424- −0.144490578  X:133680644-133680741 (−) 21 CAAAACGUGAGGCGCUGCUAU  414 star_st hsa-miR-425_st  1.324811462  3:49057581-49057667 (−) 23 AAUGACACGAUCACUCCCGUUGA  415 hsa-miR-425- −0.039392004  3:49057581-49057667 (−) 22 AUCGGGAAUGUCGUGUCCGCCC  416 star_st hsa-miR-18b_st  0.346341595  X:133304071-133304141 (−) 23 UAAGGUGCAUCUAGUGCAGUUAG  417 hsa-miR-18b-  0.303689617  X:133304071-133304141 (−) 22 UGCCCUAAAUGCCCCUUCUGGC  418 star_st hsa-miR-20b_st  0.70973838  X:133303839-133303907 (−) 23 CAAAGUGCUCAUAGUGCAGGUAG  419 hsa-miR-20b-  0.065147473  X:133303839-133303907 (−) 22 ACUGUAGUAUGGGCACUUCCAG  420 star_st hsa-miR-448_st  0.106285981  X:114058017-114058127 (+) 22 UUGCAUAUGUAGGAUGUCCCAU  421 hsa-miR-429_st  0.996620656  1:1104385-1104467 (+) 22 UAAUACUGUCUGGUAAAACCGU  422 hsa-miR-449a_st  0.166470516  5:54466360-54466450 (−) 22 UGGCAGUGUAUUGUUAGCUGGU  423 hsa-miR-450a_st  0.773772533 22 UUUUGCGAUGUGUUCCUAAUAU  424 hsa-miR-431_st  0.453467095 14:101347344-101347457 (+) 21 UGUCUUGCAGGCCGUCAUGCA  425 hsa-miR-431-  0.052895261 14:101347344-101347457 (+) 22 CAGGUCGUCUUGCAGGGCUUCU  426 star_st hsa-miR-433_st  0.414891105 14:101348223-101348315 (+) 22 AUCAUGAUGGGCUCCUCGGUGU  427 hsa-miR-329_st   1.13163936 22 AACACACCUGGUUAACCUCUUU  428 hsa-miR-451_st −0.530258722 17:27188387-27188458 (−) 22 AAACCGUUACCAUUACUGAGUU  429 hsa-miR-451_st  0.766179813  X:151128100-151128184 (−) 22 AACUGUUUGCAGAGGAAACUGA  430 hsa-miR-452- −0.435753634  X:151128100-151128184 (−) 22 CUCAUCUGCAAAGAAGUAAGUG  431 star_st hsa-miR-409-  0.293542845 14:101531637-101531715 (+) 23 AGGUUACCCGAGCAACUUUGCAU  432 5p_st hsa-miR-409-  0.439001074 14:101531637-101531715 (+) 22 GAAUGUUGCUCGGUGAACCCCU  433 3p_st hsa-miR-412_st  0.156432244 14:101531784-101531874 (+) 23 ACUUCACCUGGUCCACUAGCCGU  434 hsa-miR-410_st  0.384283979 14:101532249-101532328 (+) 21 AAUAUAACACAGAUGGCCUGU  435 hsa-miR-376b_st  0.630717733 14:101506773-101506872 (+) 22 AUCAUAGAGGAAAAUCCAUGUU  436 hsa-miR-483- −0.343228504 11:2155364-2155439 (−) 22 AAGACGGGAGGAAAGAAGGGAG  437 5p_st hsa-miR-483- −0.394618571 11:2155364-2155439 (−) 21 UCACUCCUCUCCUCCCGUCUU  438 3p_st hsa-miR-484_st  0.222490023 16:15737151-15737229 (+) 22 UCAGGCUCAGUCCCCUCCCGAU  439 hsa-miR-485-  0.033075581 14:101521756-101521828 (+) 22 AGAGGCUGGCCGUGAUGAAUUC  440 5p_st hsa-miR-485-  0.042417238 14:101521756-401521828 (+) 22 GUCAUACACGGCUCUCCUCUCU  441 3p_st hsa-miR-486- −1.137032125  8:41517959-41518026 (−) 22 UCCUGUACUGAGCUGCCCCGAG  442 5p_st hsa-miR-486- −0.836193359  8:41517959-41518026 (−) 21 CGGGGCAGCUCAGUACAGGAU  443 3p_st hsa-miR-487a_st  0.043528534 14:101518783-101518862 (+) 22 AAUCAUACAGGGACAUCCAGUU  444 hsa-miR-488- −0.005958782  1:176998499-176998581 (−) 21 CCCAGAUAAUGGCACUCUCAA  445 star_st hsa-miR-488_st  0.157128988  1:176998499-176998581 (−) 21 UUGAAAGGCUAUUUCUUGGUC  446 hsa-miR-489_st  0.107045871  7:93113248-93113331 (−) 22 GUGACAUCACAUAUACGGCAGC  447 hsa-miR-490- −0.20048518  7:136587914-136588041 (+) 20 CCAUGGAUCUCCAGGUGGGU  448 5p_st hsa-miR-490-  0.267630951  7:136587914-136588041 (+) 22 CAACCUGGAGGACUCCAUGCUG  449 3p_st hsa-miR-491- −0.346382248  9:20716104-20716187 (+) 22 AGUGGGGAACCCUUCCAUGAGG  450 5p_st hsa-miR-491- −0.061038773  9:20716104-20716187 (+) 22 CUUAUGCAAGAUUCCCUUCUAC  451 3p_st hsa-miR-511_st   0.133854408 21 GUGUCUUUUGCUCUGCAGUCA  452 hsa-miR-146b-  3.996183002 10:104196269-104196341 (+) 22 UGAGAACUGAAUUCCAUAGGCU  453 5p_st hsa-miR-146b-  2.20879991 10:104196269-104196341 (+) 22 UGCCCUGUGGACUCAGUUCUGG  454 3p_st hsa-miR-202-  0.773543112 10:135061015-135061124 (−) 22 UUCCUAUGCAUAUACUUCUUUG  455 star_st hsa-miR-202_st −0.25026034 10:135061015-135061124 (−) 20 AGAGGUAUAGGGCAUGGGAA  456 hsa-miR-492_st −0.057616195 12:95228174-95228289 (+) 23 AGGACCUGCGGGACAAGAUUCUU  457 hsa-miR-493-  1.16919763 14:101335397-101335485 (+) 22 UUGUACAUGGUAGGCUUUCAUU  458 star_st hsa-miR-493_st −0.018931488 14:101335397-101335485 (+) 22 UGAAGGUCUACUGUGUGCCAGG  459 hsa-miR-432_st −0.01535762 14:101350820-101350913 (+) 23 UCUUGGAGUAGGUCAUUGGGUGG  460 hsa-miR-432- −0.069305014 14:101350820-101350913 (+) 21 CUGGAUGGCUCCUCCAUGUCU  461 star_st hsa-miR-494_st  0.040111825 14:101495971-101496051 (+) 22 UGAAACAUACACGGGAAACCUC  462 hsa-miR-495_st  0.999893612 14:101500092-101500173 (+) 22 AAACAAACAUGGUGCACUUCUU  463 hsa-miR-496_st −0.073853056 14:101526910-101527011 (+) 22 UGAGUAUUACAUGGCCAAUCUC  464 hsa-miR-193b- −0.749675934 16:14397824-14397906 (+) 22 CGGGGUUUUGAGGGCGAGAUGA  465 star_st hsa-miR-193b_st  0.34755861 16:14397824-14397906 (+) 22 AACUGGCCCUCAAAGUCCCGCU  466 hsa-miR-497_st  0.134042327 17:6921230-6921341 (−) 21 CAGCAGCACACUGUGGUUUGU  467 hsa-miR-497- −0.449382958 17:6921230-6921341 (−) 22 CAAACCACACUGUGGUGUUAGA  468 star_st hsa-miR-181d_st  0.279397009 19:13985689-13985825 (+) 23 AACAUUCAUUGUUGUCGGUGGGU  469 hsa-miR-512- −0.112782951 23 CACUCAGCCUUGAGGGCACUUUC  470 5p_st hsa-miR-512- −0.375147916 22 AAGUGCUGUCAUAGCUGAGGUC  471 3p_st hsa-miR-498_st −0.547531217 19:54177451-54177574 (+) 23 UUUCAAGCCAGGGGGCGUUUUUC  472 hsa-miR-520e_st  0.482212017 19:54178965-54179051 (+) 21 AAAGUGCUUCCUUUUUGAGGG  473 hsa-miR-515-  0.423256921 24 UUCUCCAAAAGAAAGCACUUUCUG  474 5p_st hsa-miR-515-  0.35494522 22 GAGUGCCUUCUUUUGGAGCGUU  475 3p_st hsa-miR-519e- −0.130694532 19:54183194-54183277 (+) 22 UUCUCCAAAAGGGAGCACUUUC  476 star_st hsa-miR-519e_st  0.080062506 19:54183194-54183277 (+) 22 AAGUGCCUCCUUUUAGAGUGUU  477 hsa-miR-520f_st  0.559392629 19:54185413-54185499 (+) 22 AAGUGCUUCCUUUUAGAGGGUU  478 hsa-miR-519c- −0.306221622 19:54189723-54189809 (+) 22 CUCUAGAGGGAAGCGCUUUCUG  479 5p_st hsa-miR-519c- −0.343409838 19:54189723-54189809 (+) 22 AAAGUGCAUCUUUUUAGAGGAU  480 3p_st hsa-miR-520a- −0.304054616 19:54194135-54194219 (+) 21 CUCCAGAGGGAAGUACUUUCU  481 5p_st hsa-miR-520a-  0.098785541 19:54194135-54194219 (+) 22 AAAGUGCUUCCCUUUGGACUGU  482 3p_st hsa-miR-526b_st −0.421250558 19:54197647-54197729 (+) 23 CUCUUGAGGGAAGCACUUUCUGU  483 hsa-miR-526b-  0.32377889 19:54197647-54197729 (+) 22 GAAAGUGCUUCCUUUUAGAGGC  484 star_st hsa-miR-519b- −0.331347859 19:54198467-54198547 (+) 22 CUCUAGAGGGAAGCGCUUUCUG  485 5p_st hsa-miR-519b- −0.232036923 19:54198467-54198547 (+) 22 AAAGUGCAUCCUUUUAGAGGUU  486 3p_st hsa-miR-525- −0.312719533 19:54200787-54200871 (+) 21 CUCCAGAGGGAUGCACUUUCU  487 5p_st hsa-miR-525- −0.267350286 19:54200787-54200871 (+) 22 GAAGGCGCUUCCCUUUAGAGCG  488 3p_st hsa-miR-523- −0.672353045 19:54201639-54201725 (+) 22 CUCUAGAGGGAAGCGCUUUCUG  489 star_st hsa-miR-523_st −0.04008021 19:54201639-54201725 (+) 23 GAACGCGCUUCCCUAUAGAGGGU  490 hsa-miR-518f- −0.0545996 19:54203269-54203355 (+) 22 CUCUAGAGGGAAGCACUUUCUC  491 star_st hsa-miR-518f_st −0.014742339 19:54203269-54203355 (+) 21 GAAAGCGCUUCUCUUUAGAGG  492 hsa-miR-520b_st −0.189647326 19:54204481-54204541 (+) 21 AAAGUGCUUCCUUUUAGAGGG  493 hsa-miR-518b_st −0.558223555 19:54205991-54206073 (+) 22 CAAAGCGCUCCCCUUUAGAGGU  494 hsa-miR-526a_st −0.218681766 22 CUCUAGAGGGAAGCACUUUCUG  495 hsa-miR-520c-  0.568307623 19:54210707-54210793 (+) 22 CUCUAGAGGGAAGCACUUUCUG  496 5p_st hsa-miR-520c-  0.062702555 19:54210707-54210793 (+) 22 AAAGUGCUUCCUUUUAGAGGGU  497 3p_st hsa-miR-518c- −0.45454021 19:54211989-54212089 (+) 23 UCUCUGGAGGGAAGCACUUUCUG  498 star_st hsa-miR-518c_st −0.08750365 19:54211989-54212089 (+) 23 CAAAGCGCUUCUCUUUAGAGUGU  499 hsa-miR-524-  0.045430946 19:54214256-54214342 (+) 22 CUACAAAGGGAAGCACUUUCUC  500 5p_st hsa-miR-524- −0.375242902 19:54214256-54214342 (+) 21 GAAGGCGCUUCCCUUUGGAGU  501 3p_st hsa-miR-517- −0.199841722 22 CCUCUAGAUGGAAGCACUGUCU  502 star_st hsa-miR-517a_st −0.740187506 19:54215522-54215608 (+) 22 AUCGUGCAUCCCUUUAGAGUGU  503 hsa-miR-519d_st −0.028025737 19:54216601-54216688 (+) 22 CAAAGUGCCUCCCUUUAGAGUG  504 hsa-miR-521_st  0.032607535 22 AACGCACUUCCCUUUAGAGUGU  505 hsa-miR-520d-  0.026642305 19:54223350-54223436 (+) 20 CUACAAAGGGAAGCCCUUUC  506 5p_st hsa-miR-520d-  0.406772017 19:54223350-54223436 (+) 22 AAAGUGCUUCUCUUUGGUGGGU  507 3p_st hsa-miR-517b_st −0.229573511 19:54224330-54224396 (+) 22 UCGUGCAUCCCUUUAGAGUGUU  508 hsa-miR-520g_st −0.312270335 19:54225420-54225509 (+) 24 ACAAAGUGCUUCCCUUUAGAGUGU  509 hsa-miR-516b_st −0.5224054 22 AUCUGGAGGUAAGAAGCACUUU  510 hsa-miR-516b-  0.221707991 18 UGCUUCCUUUCAGAGGGU  511 star_st hsa-miR-518c- −0.227533992 19:54233092-54233179 (+) 22 CUCUAGAGGGAAGCGCUUUCUG  512 star_st hsa-miR-518c_st −0.414617824 19:54233092-54233179 (+) 21 AAAGCGCUUCCCUUCAGAGUG  513 hsa-miR-518a-  0.007114621 20 CUGCAAAGGGAAGCCCUUUC  514 5p_st hsa-miR-518a- −0.11579863 22 GAAAGCGCUUCCCUUUGCUGGA  515 3p_st hsa-miR-518d- −0.005453447 19:54238131-54238217 (+) 22 CUCUAGAGGGAAGCACUUUCUG  516 5p_st hsa-miR-518d-   0.53069303 19:54238131-54238217 (+) 21 CAAAGCGCUUCCCUUUGGAGC  517 3p_st hsa-miR-517c_st −0.468801766 19:54244567-54244661 (+) 22 AUCGUGCAUCCUUUUAGAGUGU  518 hsa-miR-520h_st −0.535245541 19:54245766-54245853 (+) 22 ACAAAGUGCUUCCCUUUAGAGU  519 hsa-miR-522_ −0.041532652 19:54254465-54254551 (+) 22 CUCUAGAGGGAAGCGCUUUCUG  520 star_st hsa-miR-522_st −0.582708908 19:54254465-54254551 (+) 22 AAAAUGGUUCCCUUUAGAGUGU  521 hsa-miR-519a- −0.476655144 22 CUCUAGAGGGAAGCGCUUUCUG  522 star_st hsa-miR-519a_st −1.207470298 22 AAAGUGCAUCCUUUUAGAGUGU  523 hsa-miR-527_st  0.06899744 19:54257272-54257356 (+) 20 CUGCAAAGGGAAGCCCUUUC  524 hsa-miR-516a- −0.164926747 23 UUCUCGAGGAAAGAAGCACUUUC  525 5p_st hsa-miR-516a-  0.132099039 18 UGCUUCCUUUCAGAGGGU  526 3p_st hsa-miR-499-  0.749726599 20:33578179-33578300 (+) 21 UUAAGACUUGCAGUGAUGUUU  527 5p_st hsa-miR-499-  0.377865059 20:33578179-33578300 (+) 22 AACAUCACAGCAAGUCUGUGCU  528 3p_st hsa-miR-500_st  0.438632739  X:49773039-49773122 (+) 23 UAAUCCUUGCUACCUGGGUGAGA  529 hsa-miR-500- −0.42456855  X:49773039-49773122 (+) 22 AUGCACCUGGGCAAGGAUUCUG  530 star_st hsa-miR-501- −0.135102225  X:49774330-49774413 (+) 22 AAUCCUUUGUCCCUGGGUGAGA  531 5p_st hsa-miR-501-  0.101944124  X:49774330-49774413 (+) 22 AAUGCACCCGGGCAAGGAUUCU  532 3p_st hsa-miR-502- −0.026150917  X:49779206-49779291 (+) 21 AUCCUUGCUAUCUGGGUGCUA  533 5p_st hsa-miR-502-  0.050161315  X:49779206-49779291 (+) 22 AAUGCACCUGGGCAAGGAUUCA  534 3p_st hsa-miR-503_st −0.323947388  X:133680358-133680428 (−) 23 UAGCAGCGGGAACAGUUCUGCAG  535 hsa-miR-504_st  −0.042496164  X:137749872-137749954 (−) 22 AGACCCUGGUCUGCACUCUAUC  536 hsa-miR-505- −0.236339932  X:139006307-139006390 (−) 22 GGGAGCCAGGAAGUAUUGAUGU  537 star_st hsa-miR-505_st  0.547035344  X:139006307-139006390 (−) 22 CGUCAACACUUGCUGGUUUCCU  538 hsa-miR-513a- −0.170439794 18 UUCACAGGGAGGUGUCAU  539 5p_st hsa-miR-513a-  0.021131387 23 UAAAUUUCACCUUUCUGAGAAGG  540 3p_st hsa-miR-506_st −0.035103939  X:146312238-146312361 (−) 21 UAAGGCACCCUUCUGAGUAGA  541 hsa-miR-507_st −0.161893667  X:146312502-146312595 (−) 21 UUUUGCACCUUUUGGAGUGAA  542 hsa-miR-508- −0.403192169  X:146318431-146318545 (−) 23 UACUCCAGAGGGCGUCACUCAUG  543 5p_st hsa-miR-508-  0.600164117  X:146318431-146318545 (−) 23 UGAUUGUAGCCUUUUGGAGUAGA  544 3p_st hsa-miR-509-  0.098605249 21 UACUGCAGACAGUGGCAAUCA  545 5p_st hsa-miR-509-  0.048840256 22 UGAUUGGUACGUCUGUGGGUAG  546 3p_st hsa-miR-510_st −0.25440859  X:146333853-146353926 (−) 22 UACUCAGGAGAGUGGCAAUCAC  547 hsa-miR-514_st −0.035560896 21 AUUGACACUUCUGUGAGUAGA  548 hsa-miR-532- −0.104257757  X:49767754-49767844 (+) 22 CAUGCCUUGAGUGUAGGACCGU  549 5p_st hsa-miR-532- −0.268605096  X:49767754-49767844 (+) 22 CCUCCCACACCCAAGGCUUGCA  550 3p_st hsa-miR-455-  0.337768864  9:116971714-116971809 (+) 22 UAUGUGCCUUUGGACUACAUCG  551 5p_st hsa-miR-455- −0.07615287  9:116971714-116971809 (+) 21 GCAGUCCAUGGGCAUAUACAC  552 3p_st hsa-miR-539_st  0.687043185 14:101513658-101513735 (+) 22 GGAGAAAUUAUCCUUGGUGUGU  553 hsa-miR-544_st −0.05428565 14:101514995-101515085 (+) 22 AUUCUGCAUUUUUAGCAAGUUC  554 hsa-miR-545-  0.207542716  X:73506939-73507044 (−) 22 UCAGUAAAUGUUUAUUAGAUGA  555 star_st hsa-miR-545_st −0.098963665  X:73506939-73507044 (−) 22 UCAGCAAACAUUUAUUGUGUGC  556 hsa-miR-487b_st  0.956196746 14:101512792-101512875 (+) 22 AAUCGUACAGGGUCAUCCACUU  557 hsa-miR-551a_st  0.227567501  1:3477259-3477354 (−) 21 GCGACCCACUCUUGGUUUCCA  558 hsa-miR-552_st  0.23364223  1:35135200-35135295 (−) 21 AACAGGUGACUGGUUAGACAA  559 hsa-miR-553_st −0.147296893  1:100746797-100746864 (+)  21 AAAACGGUGAGAUUUUGUUUU  560 hsa-miR-554_st −0.011540398  1:151518272-151518367 (+) 21 GCUAGUCCUGACUCAGCCAGU  561 hsa-miR-92b- −0.542496243  1:155164968-155165063 (+) 22 AGGGACGGGACGCGGUGCAGUG  562 star_st hsa-miR-92b_st −0.14926178  1:155164968-155165063 (+) 22 UAUUGCACUCGUCCCGGCCUCC  563 hsa-miR-555_st   0.0865631  1:155316141-155316236 (−) 21 AGGGUAAGCUGAACCUCUGAU  564 hsa-miR-556-  0.065353696  1:162312336-162312430 (+) 22 GAUGAGCUCAUUGUAAUAUGAG  565 5p_st hsa-miR-556-   0.48368382  1:162312336-162312430 (+) 22 AUAUUACCAUUAGCUCAUCUUU  566 3p_st hsa-miR-557_st −0.848077223  1:168344762-168344859 (+) 23 GUUUGCACGGGUGGGCCUUGUCU  567 hsa-miR-558_st  0.570822562  2:32757220-32757313 (+) 19 UGAGCUGCUGUACCAAAAU  568 hsa-miR-559_st  0.371533619  2:47604814-47604909 (+) 21 UAAAGUAAAUAUGCACCAAAA  569 hsa-miR-561_st  0.298993037  2:189162219-189162315 (+) 22 CAAAGUUUAAGAUCCUUGAAGU  570 hsa-miR-562_st −0.07259205  2:233037363-233037457 (+) 20 AAAGUAGCUGUACCAUUUGC  571 hsa-miR-563_st  0.199429719  3:15915278-15915356 (+) 19 AGGUUGACAUACGUUUCCC  572 hsa-miR-564_st −0.2969312  3:44903380-44903473 (+) 19 AGGCACGGUGUCAGCAGGC  573 hsa-miR-566_st −0.238839377  3:50210759-50210852 (+) 19 GGGCGCCUGUGAUCCCAAC  574 hsa-miR-567_st −0.436437282  3:111831648-111831745 (+) 23 AGUAUGUUCUUCCAGGACAGAAC  575 hsa-miR-568_st −0.194443772  3:114035322-114033416 (−) 20 AUGUAUAAAUGUAUACACAC  576 hsa-miR-551b- −0.024490803  3:168269642-168269737 (+) 22 GAAAUCAAGCGUGGGUGAGACC  577 star_st hsa-miR-551b_st  1.886743732  3:168269642-168269737 (+) 21 GCGACCCAUACUUGGUUUCAG  578 hsa-miR-569_st −0.223246676  3:170824453-170824548 (−) 21 AGUUAAUGAAUCCUGGAAAGU  579 hsa-miR-570_st  0.449888664  3:195426272-195426368 (+) 22 CGAAAACAGCAAUUACCUUUGC  580 hsa-miR-571_st  0.21553837  4:343946-344041 (+) 21 UGAGUUGGCCAUCUGAGUGAG  581 hsa-miR-572_st −0.560537877  4:11370451-11370545 (+) 20 GUCCGCUCGGCGGUGGCCCA  582 hsa-miR-573_st −0.477735488  4:24521815-24521913 (−) 24 CUGAAGUGAUGUGUAACUGAUCAG  583 hsa-miR-574- −0.561164498  4:38869653-38869748 (+) 23 UGAGUGUGUGUGUGUGAGUGUGU  584 5p_st hsa-miR-574- −0.032326635  4:38869653-38869748 (+) 22 CACGCUCAUGCACACACCCACA  585 3p_st hsa-miR-575_st −0.01201755  4:83674490-83674583 (−) 19 GAGCCAGUUGGACAGGAGC  586 hsa-miR-576-  0.095403984  4:110409854-110409951 (+) 22 AUUCUAAUUUCUCCACGUCUUU  587 5p_st hsa-miR-576-  0.003145179  4:110409854-110409951 (+) 22 AAGAUGUGGAAAAAUUGGAAUC  588 3p_st hsa-miR-577_st  0.431296077  4:115577915-115578010 (+) 21 UAGAUAAAAUAUUGGUACCUG  589 hsa-miR-578_st  0.659167305  4:166307394-166307489 (+) 21 CUUCUUGUGCUCUAGGAUUGU  590 hsa-miR-579_st  0.419680008  5:32394484-32394581 (−) 23 UUCAUUUGGUAUAAACCGCGAUU  591 hsa-miR-580_st −0.519250306  5:36147994-36148090 (−) 22 UUGAGAAUGAUGAAUCAUUAGG  592 hsa-miR-581_st −0.360717853  5:53247334-53247429 (−) 21 UCUUGUGUUCUCUAGAUCAGU  593 hsa-miR-582-  0.654531481  5:58999432-58999529 (−) 23 UUACAGUUGUUCAACCAGUUACU  594 5p_st hsa-miR-582-  0.206923235  5:58999432-58999529 (−) 22 UAACUGGUUGAACAACUGAACC  595 3p_st hsa-miR-583_st  0.015713694  5:95414842-95414916 (+) 21 CAAAGAGGAAGGUCCCAUUAC  596 hsa-miR-584_st  0.260079153  5:148441876-148441972 (−) 22 UUAUGGUUUGCCUGGGACUGAG  597 hsa-miR-585_st −0.19802712  5:168690605-168690698 (−) 19 UGGGCGUAUCUGUAUGCUA  598 hsa-miR-548a-  0.05546039 22 CAAAACUGGCAAUUACUUUUGC  599 3p_st hsa-miR-586_st −0.107151837  6:45165411-45165507 (−) 22 UAUGCAUUGUAUUUUUAGGUCC  600 hsa-miR-587_st  0.201686654  6:107232000-107232095 (+) 21 UUUCCAUAGGUGAUGAGUCAC  601 hsa-miR-548b-  0.064324541  6:119390212-119390308 (−) 22 AAAAGUAAUUGUGGUUUUGGCC  602 5p_st hsa-miR-548b-  0.511981078  6:119390212-119390308 (−) 22 CAAGAACCUCAGUUGCUUUUGU  603 3p_st hsa-miR-588_st  0.119934863  6:126805777-126805859 (+) 21 UUGGCCACAAUGGGUUAGAAC  604 hsa-miR-589_st  0.236078491  7:5535450-5535548 (−) 22 UGAGAACCACGUCUGCUCUGAG  605 hsa-miR-589- −0.001139358  7:5535450-5535548 (−) 24 UCAGAACAAAUGCCGGUUCCCAGA  606 star_st hsa-miR-550_st −0.195598432 23 AGUGCCUGAGGGAGUAAGAGCCC  607 hsa-miR-550-  0.221295836 23 UGUCUUACUCCCUCAGGCACAU  608 star_st hsa-miR-590-  0.16442954  7:73605528-73605624 (+) 22 GAGCUUAUUCAUAAAAGUGCAG  609 5p_st hsa-miR-590- −0.049746069  7:73605528-73605624 (+) 21 UAAUUUUAUGUAUAAGCUAGU  610 3p_st hsa-miR-591_st −0.141851032  7:95848974-95849068 (−) 20 AGACCAUGGGUUCUCAUUGU  611 hsa-miR-592_st  0.322713552  7:126698142-126698238 (−) 22 UUGGUCAAUAUGCGAUGAUGU  612 hsa-miR-593- −0.03399546  7:127721913-127722012 (+) 25 AGGCACCAGCCAGGCAUUGCUCAGC  613 star_st hsa-miR-593_st −0.043538192  7:127721913-127722012 (+) 19 UGUCUCUGCUGGGGUUUCU  614 hsa-miR-595 st −0.140019306  7:158325410-158325505 (−) 21 GAAGUGUGCCGUGGUGUGUCU  615 hsa-miR-596_st −0.782494109  8:1765397-1765473 (+) 21 AAGCCUGCCCGGCUCCUCGGG  616 hsa-miR-597_st  0.254557713  8:9599182-9599278 (+) 22 UGUGUCACUCGAUGACCACUGU  617 hsa-miR-598_st  0.719291732  8:10892716-10892812 (−) 22 UACGUCAUCGUUGUCAUCGUCA  618 hsa-miR-599_st  0.341052563  8:100548864-100548958 (−) 20 GUUGUGUCAGUUUAUCAAAC  619 hsa-miR-548a-  0.144268332 22 AAAAGUAAUUGCGAGUUUUACC  620 5p_st hsa-miR-600_st  0.21359635  9:125873825-125873922 (−) 23 ACUUACAGACAAGAGCCUUGCUC  621 hsa-miR-601_st −0.037995238  9:126164804-126164882 (−) 22 UGGUCUAGGAUUGUUGGAGGAG  622 hsa-miR-602_st −0.59149535  9:140732871-140732968 (+) 23 GACACGGGCGACAGCUGCGGCCC  623 hsa-miR-603_st  0.153581012 10:24564614-24564710 (+) 22 CACACACUGCAAUUACUUUUGC  624 hsa-miR-604_st  0.051861448 10:29833933-29834026 (−) 19 AGGCUGCGGAAUUCAGGAC  625 hsa-miR-605_st −0.151798212 10:53059333-53059415 (+) 23 UAAAUCCCAUGGUGCCUUCUCCU  626 hsa-miR-606_st  0.321319999 10:77312216-77312311 (+) 21 AAACUACUGAAAAUCAAAGAU  627 hsa-miR-607_st  0.381590014 10:98588426-98588521 (−) 21 GUUCAAAUCCAGAUCUAUAAC  628 hsa-miR-608_st −0.523042342 10:102734742-102734841 (+) 25 AGGGGUGGUGUUGGGACAGCUCCGU  629 hsa-miR-609_st −0.252595945 10:105978547-105978641 (−) 20 AGGGUGUUUCUCUCAUCUCU  630 hsa-miR-610_st  0.356352246 11:28078362-28078457 (+) 21 UGAGCUAAAUGUGUGCUGGGA  631 hsa-miR-611_st −0.625890778 11:61559967-61560033 (−) 23 GCGAGGACCCCUCGGGGUCUGAC  632 hsa-miR-612_st −0.597505963 11:65211929-65212028 (+) 25 GCUGGGCAGGGCUUCUGAGCUCCUU  633 hsa-miR-613_st  0.129893178 12:12917583-12917677 (+) 20 AGGAAUGUUCCUUCUUUGCC  634 hsa-miR-614_st  0.169744108 12:13068763-13068852 (+) 23 GAACGCCUGUUCUUGCCAGGUGG  635 hsa-miR-615- −0.546348066 12:54427734-54427829 (+) 22 GGGGGUCCCCGGUGCUCGGAUC  636 5p_st hsa-miR-615- −0.558062945 12:54427734-54427829 (+) 22 UCCGAGCCUGGGUCUCCCUCUU  637 3p_st hsa-miR-616-  0.150826863 12:57912946-57913042 (−) 22 ACUCAAAACCCUUCAGUGACUU  638 star_st hsa-miR-616_st −0.593150398 12:57912946-57913042 (−) 22 AGUCAUUGGAGGGUUUGAGCAG  639 hsa-miR-548c-  0.20696522 12:65016289-65016385 (+) 22 AAAAGUAAUUGCGGUUUUUGCC  640 5p_st hsa-miR-548c-  0.38824374 12:65016289-65016385 (+) 22 CAAAAAUCUCAAUUACUUUUGC  641 3p_st hsa-miR-617_st  0.179802415 12:81226312-81226408 (−) 22 AGACUUCCCAUUUGAAGGUGGC  642 hsa-miR-618_st  0.301761441 12:81329515-81329612 (−) 23 AAACUCUACUUGUCCUUCUGAGU  643 hsa-miR-619_st  0.05602629 12:109230684-109230782 (−) 24 GACCUGGACAUGUUUGUGCCCAGU  644 hsa-miR-620_st  0.170970712 12:116586365-116586459 (−) 20 AUGGAGAUAGAUAUAGAAAU  645 hsa-miR-621_st −0.133416356 13:41384902-41384997 (+) 21 GGCUAGCAACAGCGCUUACCU  646 hsa-miR-622_st  0.175781108 13:90883436-90883531 (+) 21 ACAGUCUGCUGAGGUUGGAGC  647 hsa-miR-623_st −0.649568833 13:100008385-100008482 (+) 23 AUCCCUUGCAGGGGCUGUUGGGU  648 hsa-miR-624- −0.111181783 14:31483852-31483948 (−) 22 UAGUACCAGUACCUUGUGUUCA  649 star_st hsa-miR-624_st −0.470763983 14:31483852-31483948 (−) 21 CACAAGGUAUUGGUAUUACCU  650 hsa-miR-625_st −0.237221077 14:65937820-65937904 (+) 21 AGGGGGAAAGUUCUAUAGUCC  651 hsa-miR-625- −0.04463785 14:65937820-65937904 (+) 22 GACUAUAGAACUUUCCCCCUCA  652 star_st hsa-miR-626_st  0.420281913 15:41983783-41983876 (+) 19 AGCUGUCUGAAAAUGUCUU  653 hsa-miR-627_st  0.049034464 15:42491768-42491864 (−) 22 GUGAGUCUCUAAGAAAAGAGGA  654 hsa-miR-628-  0.178537539 15:55665138-55665232 (−) 22 AUGCUGACAUAUUUACUAGAGG  655 5p_st hsa-miR-628- −0.07636519 15:55665138-55665232 (−) 21 UCUAGUAAGAGUGGCAGUCGA  656 3p_st hsa-miR-629_st  0.310237475 15:70371711-70371807 (−) 21 UGGGUUUACGUUGGGAGAACU  657 hsa-miR-629- −0.062387318 15:70371711-70371807 (−) 22 GUUCUCCCAACGUAAGCCCAGC  658 star_st hsa-miR-630_st −0.071442144 15:72879558-72879654 (+) 22 AGUAUUCUGUACCAGGGAAGGU  659 hsa-miR-631_st −0.128933028 15:75645952-75646026 (−) 21 AGACCUGGCCCAGACCUCAGC  660 hsa-miR-33b_st −0.149152609 17:17717150-17717245 (−) 20 GUGCAUUGCUGUUGCAUUGC  661 hsa-miR-33b- −0.335924749 17:17717150-17717245 (−) 22 CAGUGCCUCGGCAGUGCAGCCC  662 star_st hsa-miR-632_st  0.194451438 17:30677128-30677221 (+) 19 GUGUCUGCUUCCUGUGGGA  663 hsa-miR-633_st  0.194132983 17:61021576-61021673 (+) 23 CUAAUAGUAUCUACCACAAUAAA  664 hsa-miR-634_st  0.016003366 17:64783190-64783286 (+) 22 AACCAGCACCCCAACUUUGGAC  665 hsa-miR-635_st −0.1564536 17:66420592-66420689 (−) 23 ACUUGGGCACUGAAACAAUGUCC  666 hsa-miR-636_st −0.782589366 17:74732532-74732630 (−) 23 UGUGCUUGCUCGUCCCGCCCGCA  667 hsa-miR-637_st −0.697029065 19:3961412-3961510 (−) 24 ACUGGGGGCUUUCGGGCUCUGCGU  668 hsa-miR-638_st −0.422208669 19:10829080-10829179 (+) 25 AGGGAUCGCGGGCGGGUGGCGGCCU  669 hsa-miR-639_st −0.668433943 19:14640355-14640452 (+) 23 AUCGCUGCGGUUGCGAGCGCUGU  670 hsa-miR-640_st −0.248474937 19:19545872-19545967 (+) 21 AUGAUCCAGGAACCUGCCUCU  671 hsa-miR-641_st  0.037050977 19:40788450-40788548 (−) 24 AAAGACAUAGGAUAGAGUCACCUC  672 hsa-miR-642_st  0.494383667 19:46178186-46178282 (+) 22 GUCCCUCUCCAAAUGUGUCUUG  673 hsa-miR-643_st  0.235850589 19:52785050-52785146 (+) 22 ACUUGUAUGCUAGCUCAGGUAG  674 hsa-miR-644_st −0.074050142 20:33054130-33054223 (+) 19 AGUGUGGCUUUCUUAGAGC  675 hsa-miR-645_st  0.160387161 20:49202323-49202416 (+) 19 UCUAGGCUGGUACUGCUGA  676 hsa-miR-646_st  0.051778024 20:58883532-58883625 (+) 19 AAGCAGCUGCCUCUGAGGC  677 hsa-miR-647_st −0.305580715 20:62573984-62574079 (−) 21 GUGGCUGCACUCACUUCCUUC  678 hsa-miR-648_st −0.349328299 22:18463634-18463727 (−) 19 AAGUGUGCAGGGCACUGGU  679 hsa-miR-649_st  0.093994137 22:21388465-21388561 (−) 22 AAACCUGUGUUGUUCAAGAGUC  680 hsa-miR-650_st −0.050464632 22:23165270-23165365 (+) 21 AGGAGGCAGCGCUCUCAGGAC  681 hsa-miR-651_st  0.119970741  X:8095006-8095102 (+) 22 UUUAGGAUAAGCUUGACUUUUG  682 hsa-miR-652_st −0.119768033  X:109298557-109298654 (+) 21 AAUGGCGCCACUAGGGUUGUG  683 hsa-miR-548d-  0.076408458 22 AAAAGUAAUUGUGGUUUUUGCC  684 5p_st hsa-miR-548d-  0.430544966 22 CAAAAACCACAGUUUCUUUUGC  685 3p_st hsa-miR-661_st −0.616026446  8:145019359-145019447 (−) 24 UGCCUGGGUCUCUGGCCUGCGCGU  686 hsa-miR-662_st  0.261225179 16:820183-820277 (+) 21 UCCCACGUUGUGGCCCAGCAG  687 hsa-miR-663_st −0.480625269 20:26188822-26188914 (−) 22 AGGCGGGGCGCCGCGGGACCGC  688 hsa-miR-449b_st  0.198658827  5:54466474-54466570 (−) 23 AGGCAGUGUAUUGUUAGCUGGC  689 hsa-miR-449b- −0.560389688  5:54466474-54466570 (−) 22 CAGCCACAACUACCCUGCCACU  690 star_st hsa-miR-653_st  0.191868449  7:93112072-93112167 (−) 21 GUGUUGAAACAAUCUCUACUG  691 hsa-miR-411_st  0.136686066 14:101489662-101489757 (+) 21 UAGUAGACCGUAUAGCGUACG  692 hsa-miR-411-  0.120011956 14:101489662-101489757 (+) 22 UAUGUAACACGGUCCACUAACC  693 star_st hsa-miR-654- −0.472232433 14:101506556-101506636 (+) 22 UGGUGGGCCGCAGAACAUGUGC  694 5p_st hsa-miR-654-  0.264747585 14:101506556-101506636 (+) 22 UAUGUCUGCUGACCAUCACCUU  695 3p_st hsa-miR-655_st  0.480326216 14:101515887-101515983 (+) 22 AUAAUACAUGGUUAACCUCUUU  696 hsa-miR-656_st −0.264321396 14:101533061-101533138 (+) 21 AAUAUUAUACAGUCAACCUCU  697 hsa-miR-549_st −0.048354407 15:81134319-81134414 (−) 21 UGACAACUAUGGAUGAGCUCU  698 hsa-miR-657_st  0.227310786 17:79099076-79099173 (−) 23 GGCAGGUUCUCACCCUCUCUAGG  699 hsa-miR-658_st −0.529914071 22:38240279-38240378 (−) 25 GGCGGAGGGAAGUAGGUCCGUUGGU  700 hsa-miR-659_st −0.577515457 22:38243685-38243781 (−) 22 CUUGGUUCAGGGAGGGUCCCCA  701 hsa-miR-660_st  0.561018419  X:49777849-49777945 (+) 22 UACCCAUUGCAUAUCGGAGUUG  702 hsa-miR-421_st  0.627401792  X:73438212-73438296 (−) 23 AUCAACAGACAUUAAUUGGGCGC  703 hsa-miR-542-  0.00378439  X:133675371-133675467 (−) 23 UCGGGGAUCAUCAUGUCACGAGA  704 5p_st hsa-miR-542-  0.559020355  X:133675371-133675467 (−) 22 UGUGACAGAUUGAUAACUGAAA  705 3p_st hsa-miR-758_st  0.019688671 14:101492357-101492444 (+) 22 UUUGUGACCUGGUCCACUAACC  706 hsa-miR-1264_st  0.452195997  X:113887130-113887198 (+) 23 CAAGUCUUAUUUGAGCACCUGUU  707 hsa-miR-671- −0.364430355  7:150935507-150935624 (+) 23 AGGAAGCCCUGGAGGGGCUGGAG  708 5p_st hsa-miR-671-  0.167684298  7:150935507-150935624 (+) 21 UCCGGUUCUCAGGGCUCCACC  709 3p_st hsa-miR-668_st −0.632007016 14:101321595-101521660 (+) 23 UGUCACUCGGCUCGGCCCACUAC  710 hsa-miR-767-  0.125211371  X:151561893-151562001 (−) 23 UGCACCAUGGUUGUCUGAGCAUG  711 5p_st hsa-miR-767-  0.241188916  X:151561893-151562001 (−) 23 UCUGCUCAUACCCCAUGGUUUCU  712 3p_st hsa-miR-1224- −0.326933758  3:183959193-183959277 (+) 19 GUGAGGACUCGGGAGGUGG  713 5p_st hsa-miR-1224- −0.099987848  3:183959193-183959277 (+) 21 CCCCACCUCCUCUCUCCUCAG  714 3p_st hsa-miR-320b_st −0.353894764 22 AAAAGCUGGGUUGAGAGGGCAA  715 hsa-miR-320c_st −0.148187748 20 AAAAGCUGGGUUGAGAGGGU  716 hsa-miR-1296_st −0.256319335 10:65132717-65132808 (−) 22 UUAGGGCCCUGGCUCCAUCUCC  717 hsa-miR-1468_st −0.153590312  X:63005882-63005967 (−) 21 CUCCGUUUGCCUGUUUCGCUG  718 hsa-miR-1323_st −0.496797108 19:54175222-54175294 (+) 22 UCAAAACUGAGGGGCAUUUUCU  719 hsa-miR-1271_st  0.369484935  5:175794949-175795034 (+)  22 CUUGGCACCUAGCAAGCACUCA  720 hsa-miR-1301_st  0.1010758  2:25551509-25551590 (−) 24 UUGCAGCUGCCUGGGAGUGACUUC  721 hsa-miR-454-  0.061800153 17:57215119-57215233 (−)  22 ACCCUAUCAAUAUUGUCUCUGC  722 star_st hsa-miR-454_st  1.312831049 17:57215119-57215233 (−) 23 UAGUGCAAUAUUGCUUAUAGGGU  723 hsa-miR-1185_st  9.24573E−05 21 AGAGGAUACCCUUUGUAUGUU  724 hsa-miR-449c_st −0.310930519  5:54468090-54468181 (−) 25 UAGGCAGUGUAUUGCUAGCGGCUGU  725 hsa-miR-449c- −0.471675579  5:54468090-54468181 (−) 23 UUGCUAGUUGCACUCCUCUCUGU  726 star_st hsa-miR-1283_st −0.053277143 22 UCUACAAAGGAAAGCGCUUUCU  727 hsa-miR-769-  0.387224935 19:46522190-46322307 (+) 22 UGAGACCUCUGGGUUCUGAGCU  728 5p_st hsa-miR-769- −0.612189973 19:46522190-46522307 (+) 23 CUGGGAUCUCCGGGGUCUUGGUU  729 3p_st hsa-miR-766_st  0.007320627   X:118780701-118780811 (−) 22 ACUCCAGCCCCACAGCCUCAGC  730 hsa-miR-762_st −0.446795615 16:10905224-30905306 (+) 22 GGGGCUGGGGCCGGGGCCGAGC  731 hsa-miR-802_st −0.017774103 21:37093013-37093106 (+) 23 CAGUAACAAAGAUUCAUCCUUGU  732 hsa-miR-670_st −0.092740756 11:43581206-43581303 (+) 20 GUCCCUGAGUGUAUGUGGUG  733 hsa-miR-1248_st  0.326000027  X:113949650-113949761 (+) 22 UUCAUUCGGCUGUCCAGAUGUA  734 hsa-miR-2113_st  0.14939042  6:98472407-98472497 (+) 21 AUUUGUGCUUGGCUCUGUCAC  735 hsa-miR-761_st −0.335788423  1:52302016-52302074 (−) 22 GCAGCAGGGUGAAACUGACACA  736 hsa-miR-764_st   0.368644739  X:113873918-113874002 (+) 22 GCAGGUGCUCACUUGUCCUCCU  737 hsa-miR-759_st  0.388215181 13:53384185-53384275 (+) 22 GCAGAGUGCAAACAAUUUUGAC  738 hsa-miR-765_st −0.265455113  1:156905923-156906036 (−) 21 UGGAGGAGAAGGAAGGUGAUG  739 hsa-miR-770- −0.406433427 14:101318727-101318824 (+) 23 UCCAGUACCACGUGUCAGGGCCA  740 5p_st hsa-miR-675_st −0.465904133 11:2017989-2018061 (−) 23 UGGUGCGGAGAGGGCCCACAGUG  741 hsa-miR-675- −0.733207197 11:2017989-2018061 (−) 20 CUGUAUGCCCUCACCGCUCA  742 star_st hsa-miR-298_st −0.342997868 20:57393281-57393368 (−)  23 AGCAGAAGCAGGGAGGUUCUCCCA  743 hsa-miR-891a_st  0.415131889  X:145109312-145109390 (−) 22 UGCAACGAACCUGAGCCACUGA  744 hsa-miR-300_st −0.156884271 14:101507700-101507782 (+) 22 UAUACAAGGGCAGACUCUCUCU  745 hsa-miR-886- −0.7111646  5:135416177-135416297 (−) 23 CGGGUCGGAGUUAGCUCAAGCGG  746 5p_st hsa-miR-886- −0.265754631  5:135416177-135416297 (−) 21 CGCGGGUGCUUACUGACCCUU  747 3p_st hsa-miR-892a_st −0.0178816  X:145078187-145078261 (−) 21 CACUGUGUCCUUUCUGCGUAG  748 hsa-miR-220b_st −0.183033422 19:6495959-6496045 (+) 21 CCACCACCGUGUCUGACACUU  749 hsa-miR-450b-  0.389809937  X:133674215-133674292 (−) 22 UUUUGCAAUAUGUUCCUGAAUA  750 5p_st hsa-miR-450b-  0.049147767  X:133674215-133674292 (−) 22 UUGGGAUCAUUUUGCAUCCAUA  751 3p_st hsa-miR-874_st −0.157649315  5:136933261-136983338 (−) 22 CUGCCCUGGCCCGAGGGACCGA  752 hsa-miR-890_st  0.760488224  X:145075793-145075869 (−) 21 UACUUGGAAAGGCAUCAGUUG  753 hsa-miR-891b_st  0.743488807  X:145082571-145082649 (−) 22 UGCAACUUACCUGAGUCAUUGA  754 hsa-miR-220c_st  0.076507092 19:49063529-49063611 (−) 22 ACACAGGGCUGUUGUGAAGACU  755 hsa-miR-888_st  0.674792334  X:145076302-145076378 (−)  21 UACUCAAAAAGCUGUCAGUCA  756 hsa-miR-888- −0.055511439  X:145076302-145076378 (−) 22 GACUGACACCUCUUUGGGUGAA  757 star_st hsa-miR-892b_st  0.58203853  X:145078716-145078792 (−) 22 CACUGGCUCCUUUCUGGGUAGA  758 hsa-miR-541- −0.270351489 14:101530832-101530915 (+) 25 AAAGGAUUCUGCUGUCGGUCCCACU  759 star_st hsa-miR-541_st −0.426868452 14:101530832-101530915 (+) 22 UGGUGGGCACAGAAUCUGGACU  760 hsa-miR-889_st  0.168340573 14:101514238-101514316 (+) 21 UUAAUAUCGGACAACCAUUGU  761 hsa-miR-875- −0.464819734  8:100549014-100549089 (−) 22 UAUACCUCAGUUUUAUCAGGUG  762 5p_st hsa-miR-875-  0.265824374  8:100549014-100549089 (−) 21 CCUGGAAACACUGAGGUUGUG  763 3p_st hsa-miR-876- −0.212025682  9:28863624-28863704 (−) 22 UGGAUUUCUUUGUGAAUCACCA  764 5p_st hsa-miR-876-  0.101773622  9:28863624-28863704 (−) 22 UGGUGGUUUACAAAGUAAUUCA  765 3p_st hsa-miR-708_st −0.148807187 11:79113066-79113153 (−) 23 AAGGAGCUUACAAUCUAGCUGGG  766 hsa-miR-708- −0.25648189 11:79113066-79113153 (−) 22 CAACUAGACUGUGAGCUUCUAG  767 star_st hsa-miR-147b_st −0.12357752 15:45725248-45725327 (+) 22 GUGUGCGGAAAUGCUUCUGCUA  768 hsa-miR-190b_st −0.653593416  1:154166141-154166219 (−) 21 UGAUAUGUUUGAUAUUGGGUU  769 hsa-miR-744_st −0.439822595 17:11985216-11985313 (+) 23 UGCGGGGCUAGGGCUAACAGCA  770 hsa-miR-744-  0.378794923 17:11985216-11985313 (+) 22 CUGUUGCCACUAACCUCAACCU  771 star_st hsa-miR-885- −0.916203074  3:10436173-10436246 (−) 22 UCCAUUACACUACCCUGCCUCU  772 5p_st hsa-miR-885- −0.75194678  3:10436173-10436246 (−) 22 AGGCAGCGGGGUGUAGUGGAUA  773 3p_st hsa-miR-877_st −0.324294781  6:30552109-30552194 (+) 20 GUAGAGGAGAUGGCGCAGGG  774 hsa-miR-877- −0.400447381  6:30552109-30552194 (+) 21 UCCUCUUCUCCCUCCUCCCAG  775 star_st hsa-miR-887_st −0.262112859  5:15935291-15935369 (+) 22 GUGAACGGGCGCCAUCCCGAGG  776 hsa-miR-665_st −0.176767659 14:101341370-101341441 (+) 20 ACCAGGAGGCUGAGGCCCCU  777 hsa-miR-873_st −0.070415832  9:28888877-28888953 (−) 21 GCAGGAACUUGUGAGUCUCCU  778 hsa-miR-543_st   0.386383186 14:101498324-101498401 (+) 22 AAACAUUCGCGGUGCACUUCUU  779 hsa-miR-374b_st  1.079803793  X:73438382-73438453 (−) 22 AUAUAAUACAACCUGCUAAGUG  780 hsa-miR-374b-  0.489481199  X:73438382-73438453 (−) 22 CUUAGCAGGUUGUAUUAUCAUU  781 star_st hsa-miR-760_st −0.674938847  1:94312388-94312467 (+) 20 CGGCUCUGGGUCUGUGGGGA  782 hsa-miR-301b_st  0.794315923 22:22007270-22007347 (+) 23 CAGUGCAAUGAUAUUGUCAAAGC  783 hsa-miR-216b_st  0.511660042  2:56227849-56227930 (−) 22 AAAUCUCUGCAGGCAAAUGUGA  784 hsa-miR-208b_st  0.302538439 14:23887196-23887272 (−) 22 AUAAGACGAACAAAAGGUUUGU  785 hsa-miR-920_st −0.576255005 12:24365355-24365429 (+) 20 GGGGAGCUGUGGAAGCAGUA  786 hsa-miR-921_st −0.286412503  1:166123980-166124035 (−) 25 CUAGUGAGGGACAGAACCAGGAUUC  787 hsa-miR-922_st −0.138833401  3:197401567-197401447 (−) 23 GCAGCAGAGAAUAGGACUACGUC  788 hsa-miR-924_st  0.582023843 18:37202087-37202139 (−) 20 AGAGUCUUGUGAUGUCUUGC  789 hsa-miR-509-3- −0.317242543  X:146341170-146341244 (−) 22 UACUGCAGACGUGGCAAUCAUG  790 5p_st hsa-miR-933_st  0.050795443  2:176032361-176032437 (−) 22 UGUGCGCAGGGAGACCUCUCCC  791 hsa-miR-934_st −0.008209299  X:135633037-135633119 (+) 22 UGUCUACUACUGGAGACACUGG  792 hsa-miR-935_st −0.743708446 19:54485561-54485651 (+) 23 CCAGUUACCGCUUCCGCUACCGC  793 hsa-miR-936_st −0.279060211 10:105807847-105807944 (−) 22 ACAGUAGAGGGAGGAAUCGCAG  794 hsa-miR-937_st  0.040672517  8:144895127-144895212 (−) 22 AUCCGCGCUCUGACUCUCUGCC  795 hsa-miR-938_st −0.20978976 10:29891193-29891275 (−) 22 UGCCCUUAAAGGUGAACCCAGU  796 hsa-miR-939_st −0.579938374  8:145619364-145619445 (−) 24 UGGGGAGCUGAGGCUCUGGGGGUG  797 hsa-miR-940_st −0.272587138 16:2321748-2321841 (+) 21 AAGGCAGGGCCCCCGCUCCCC  798 hsa-miR-941_st −0.068050295 23 CACCCGGCUGUGUGCACAUGUGC  799 hsa-miR-942_st  0.366729056  1:117637265-117637350 (+) 22 UCUUCUCUGUUUUGGCCAUGUG  800 hsa-miR-943_st −0.806599985  4:1988111-1988204 (−) 21 CUGACUGUUGCCGUCCUCCAG  801 hsa-miR-944_st  0.074666201  3:189547711-189547798 (+) 22 AAAUUAUUGUACAUCGGAUGAG  802 hsa-miR-297_st  0.348144584  4:111781738-111781803 (−) 21 AUGUAUGUGUGCAUGUGCAUG  803 hsa-miR-1178_st −0.118722857 12:120151439-120151529 (−) 21 UUGCUCACUGUUCUUCCCUAG  804 hsa-miR-1179_st  0.113052871 15:89151338-89151428 (+) 21 AAGCAUUCUUUCAUUGGUUGG  805 hsa-miR-1180_st −0.488976108 17:19247819-19247887 (−) 22 UUUCCGGCUCGCGUGGGUGUGU  806 hsa-miR-1181_st −0.553946496 19:10514134-10514214 (−) 21 CCGUCGCCGCCACCCGAGCCG  807 hsa-miR-1182_st −0.457543047  1:231155574-231155670 (−) 23 GAGGGUCUUGGGAGGGAUGUGAC  808 hsa-miR-1183_st −0.351318092  7:21510676-21510764 (+)  27 CACUGUAGGUGAUGGUGAGAGUGG  809 GCA hsa-miR-1184_st −0.227475628 23 CCUGCAGCGACUUGAUGGCUUCC  810 hsa-miR-1225- −0.38719767 16:2140196-2140285 (−) 22 GUGGGUACGGCCCAGUGGGGGG  811 5p_st hsa-miR-1225- −0.607399326 16:2140196-2140285 (−) 22 UGAGCCCCUGUGCCGCCCCCAG  812 3p_st hsa-miR-1226- −0.396569371  3:47891045-47891119 (+) 26 GUGAGGGCAUGCAGGCCUGGAUGG  813 star_st GG hsa-miR-1226_st −0.164177373  3:47891045-47891119 (+) 22 UCACCAGCCCUGUGUUCCCUAG  814 hsa-miR-1227_st −0.392136136 19:2234061-2234148 (−) 20 CGUGCCACCCUUUUCCCCAG  815 hsa-miR-1228-  −0.456494317 12:57588287-57588359 (+) 21 GUGGGCGGGGGCAGGUGUGUG  816 star_st hsa-miR-1228_st −0.429305902 12:57588287-57588359 (+) 20 UCACACCUGCCUCGCCCCCC  817 hsa-miR-1229_st −0.440646346  5:179225278-179225346 (−) 23 CUCUCACCACUGCCCUCCCACAG  818 hsa-miR-1231_st −0.698665174  1:201777739-201777830 (+) 20 GUGUCUGGGCGGACAGCUGC  819 hsa-miR-1233_st −0.327747499 20 UGAGCCCUGUCCUCCCGCAG  820 hsa-miR-1234_st −0.274407678  8:145625476-145625559 (−) 22 UCGGCCUGACCACCCACCCCAC  821 hsa-miR-1236_st −0.195255274  6:31924616-31924717 (−) 22 CCUCUUCCCCUUGUCUCUCCAG  822 hsa-miR-1237_st −0.547769245 11:64136074-64136175 (+) 21 UCCUUCUCCUCCGUCCCCCAG  823 hsa-miR-1238_st −0.255447436 19:10662798-10662880 (+) 20 CUUCCUCGUCUGUCUGCCCC  824 hsa-miR-1200_st −0.358476635  7:36958962-36959037 (−) 22 CUCCUGAGCCAUUCUGAGCCUC  825 hsa-miR-1201_st  0.77001394 14:20794606-20794690 (−) 24 AGCCUGAUUAAACACAUGCUCUGA  826 hsa-miR-1202_st −0.539600384  6:156267931-156268013 (+) 21 GUGCCAGCUGCAGUGGGGGAG  827 hsa-miR-1203_st −0.098483453 17:46233789-46233873 (−) 21 CCCGGAGCCAGGAUGCAGCUC  828 hsa-miR-663b_st −0.07854292  2:133014539-133014653 (−) 22 GGUGGCCCGGCCGUGCCUGAGG  829 hsa-miR-1204_st −0.38023458  8:128808208-128808274 (+) 21 UCGUGGCCUGGUCUCCAUUAU  830 hsa-miR-1205_st  0.119236107  8:128972879-128972941 (+) 20 UCUGCAGGGUUUGCUUUGAG  831 hsa-miR-1206_st  0.61109876  8:129021144-129021202 (+) 21 UGUUCAUGUAGAUGUUUAAGC  832 hsa-miR-1207- −0.413891024  8:129061398-129061484 (+) 21 UGGCAGGGAGGCUGGGAGGGG  833 5p_st hsa-miR-1207-  −0.590440262  8:129061398-129061484 (+) 18 UCAGCUGGCCCUCAUUUC  834 3p_st hsa-miR-1208_st −0.697774512  8:129162362-129162434 (+) 20 UCACUGUUCAGACAGGCGGA  835 hsa-miR-548e_st  0.342367468 10:112748684-112748771 (+)  22 AAAAACUGAGACUACUUUUGCA  836 hsa-miR-548j_st  −0.378682535 22:26951178-26951289 (−) 22 AAAAGUAAUUGCGGUCUUUGGU  837 hsa-miR-1285_st −0.112973054 22 UCUGGGCAACAAAGUGAGACCU  838 hsa-miR-1286_st −0.329534325 22:20236657-20236734 (−) 21 UGCAGGACCAAGAUGAGCCCU  839 hsa-miR-1287_st  0.155123326 10:100154975-100155064 (−) 22 UGCUGGAUCAGUGGUUCGAGUC  840 hsa-miR-1289_st  0.109012835   23 UGGAGUCCAGGAAUCUGCAUUUU  841 hsa-miR-1290_st −0.35417404  1:19223565-19223642 (−) 19 UGGAUUUUUGGAUCAGGGA  842 hsa-miR-1291_st −0.145049331 12:49048227-49048313 (−) 24 UGGCCCUGACUGAAGACCAGCAGU  843 hsa-miR-548k_st  0.508991181 11:70130061-70130176 (+) 22 AAAAGUACUUGCGGAUUUUGCU  844 hsa-miR-1293_st −0.341052122 12:50627925-50627995 (−) 22 UGGGUGGUCUGGAGAUUUGUGC  845 hsa-miR-1294_st −0.185000925  5:153726666-153726807 (+) 22 UGUGAGGUUGGCAUUGUUGUCU  846 hsa-miR-1295_st −0.087279455  1:171070869-171070947 (−) 21 UUAGGCCGCAGAUCUGGGUGA  847 hsa-miR-1297_st  0.579269966 13:54886107-54886183 (−) 17 UUCAAGUAAUUCAGGUG  848 hsa-miR-1299_st −0.328354408  9:69002239-69002321 (−) 22 UUCUGGAAUUCUGUGUGAGGGA  849 hsa-miR-5481_st −0.098584184 11:94199661-94199746 (−) 22 AAAAGUAUUUGCGGGUUUUGUC  850 hsa-miR-1302_st −0.052798803 21 UUGGGACAUACUUAUGCUAAA  851 hsa-miR-1303_st −0.347023877  5:154065336-154065421 (+) 22 UUUAGAGACGGGGUCUUGCUCU  852 hsa-miR-1304_st  0.348603582 11:93466840-93466930 (−) 22 UUUGAGGCUACAGUGAGAUGUG  853 hsa-miR-1305_st  0.076731378  4:183090446-183090531 (+) 22 UUUUCAACUCUAAUGGGAGAGA  854 hsa-miR-1243_st −0.207192555  4:114028019-114028111 (+) 22 AACUGGAUCAAUUAUAGGAGUG  855 hsa-miR-548f_st −0.1472914 19 AAAAACUGUAAUUACUUUU  856 hsa-miR-1244_st  0.517268072 26 AAGUAGUUGGUUUGUAUGAGAUGG  857 UU hsa-miR-1245_st  0.003252269  2:189842818-189842887 (+) 21 AAGUGAUCUAAAGGCCUACAU  858 hsa-miR-1246_st −0.159547883  2:177465708-177465780 (−) 19 AAUGGAUUUUUGGAGCAGG  859 hsa-miR-1247_st −0.327805004 14:102026624-l02026759 (−) 22 ACCCGUCCCGUUCGUCCCCGGA  860 hsa-miR-1248_st  0.360334937  3:186504461-186504566 (+) 27 ACCUUCUUGUAUAAGCACUGUGCU  861 AAA hsa-miR-1249_st  0.043587535 22:45596835-45596900 (−) 22 ACGCCCUUCCCCCCCUUCUUCA  862 hsa-miR-1250_st −0.336528856 17:79106996-79107108 (−) 21 ACGGUGCUGGAUGUGGCCUUU  863 hsa-miR-1251_st  0.512971088 12:97885687-97885756 (+) 21 ACUCUAGCUGCCAAAGGCGCU  864 hsa-miR-1253_st −0.15538055 17:2651372-2651476 (−) 21 AGAGAAGAAGAUCAGCCUGCA  865 hsa-miR-1254_st −0.233801498 10:70519075-70519171 (+) 24 AGCCUGGAAGCUGGAGCCUGCAGU  866 hsa-miR-1255a_st  0.187915657  4:102251459-102251571 (−) 23 AGGAUGAGCAAAGAAAGUAGAUU  867 hsa-miR-1256_st  0.33571115  1:21314807-21314925 (−) 22 AGGCAUUGACUUCUCACUAGCU  868 hsa-miR-1257_st  0.124103955 20:60528602-60528718 (−) 21 AGUGAAUGAUGGGUUCUGACC  869 hsa-miR-1258_st  0.043788417  2:180725563-180725635 (−) 21 AGUUAGGAUUAGGUCGUGGAA  870 hsa-miR-1259_st  0.34061951 20:47896847-47896957 (+) 21 AUAUAUGAUGACUUAGCUUUU  871 hsa-miR-1260_st  0.016061699 14:77732561-77732633 (+) 18 AUCCCACCUCUGCCACCA  872 hsa-miR-548g_st  0.211530862  4:148265781-148265869 (−) 22 AAAACUGUAAUUACUUUUGUAC  873 hsa-miR-1261_st −0.112273789 11:90602289-90602370 (−) 19 AUGGAUAAGGCUUUGGCUU  874 hsa-miR-1262_st −0.200157382  1:68649201-68649293 (−) 22 AUGGGUGAAUUUGUAGAAGGAU  875 hsa-miR-1263_st −0.351098595  3:163889259-163889344 (−) 22 AUGGUACCCUGGCAUACUGAGU  876 hsa-miR-548n_st  0.042829555  7:34980372-34980446 (−) 22 CAAAAGUAAUUGUGGAUUUUGU  877 hsa-miR-548m_st  0.297403266  X:94318140-94318225 (−) 21 CAAAGGUAUUUGUGGUUUUUG  878 hsa-miR-1265_st −0.169136532 10:14478575-14478660 (+) 22 CAGGAUGUGGUCAAGUGUUGUU  879 hsa-miR-548o_st −0.431360601  7:102046189-102046302 (−) 22 CCAAAACUGCAGUUACUUUUGC  880 hsa-miR-1266_St −0.491370046 15:52569314-52569397 (−) 23 CCUCAGGGCUGUAGAACAGGGCU  881 hsa-miR-1267_st −0.375000166 13:108183519-108183596 (−) 21 CCUGUUGAAGUGUAAUCCCCA  882 hsa-miR-1268_st −0.475127329 15:22513229-22513280 (−) 18 CGGGCGUGGUGGUGGGGG  883 hsa-miR-1269_st −0.064540701  4:67142542-67142646 (+) 22 CUGGACUGAGCCGUGCUACUGG  884 hsa-miR-1270_st −0.125725591 23 CUGGAGAUAUGGAAGAGCUGUGU  885 hsa-miR-1272_st −0.024170509 15:65054586-65054714 (−) 26 GAUGAUGAUGGCAGCAAAUUCUGA  886 AA hsa-miR-1273_st −0.092136851  8:101036210-101036312 (−) 25 GGGCGACAAAGCAAGACUCUUUCUU  887 hsa-miR-  1.087481971  5:41475734-41475804 (+) 18 GUCCCUGUUCAGGCGCCA  888 1274n_st hsa-miR-548h_st  0.36654465 22 AAAAGUAAUCGCGGUUUUUGUC  889 hsa-miR-1275_st −0.378876303  6:33967749-33967828 (−) 17 GUGGGGGAGAGGCUGUC  890 hsa-miR-1276_st −0.208238828 15:86313727-86313809 (−) 20 UAAAGAGCCCUGUGGAGACA  891 hsa-miR-302e_st −0.354429514 11:7255997-7256068 (+) 17 UAAGUGCUUCCAUGCUU  892 hsa-miR-302f_st  0.403378813 18:27878876-27878926 (+) 17 UAAUUGCUUCCAUGUUU  893 hsa-miR-1277_st −0.046188492  X:117520357-117520434 (+) 22 UACGUAGAUAUAUAUGUAUUUU  894 hsa-miR-548p_st  0.147242156  5:100152186-100152269 (−) 22 UAGCAAAAACUGCAGUUACUUU  895 hsa-miR-548i_st  0.085843127 22 AAAAGUAAUUGCGGAUUUUGCC  896 hsa-miR-1278_st  0.140507622  1:193105633-193105713 (+) 22 UAGUACUGUGCAUAUCAUCUAU  897 hsa-miR-1279_st  0.497329076 12:69666937-69666998 (−) 17 UCAUAUUGCUUCUUUCU  898 hsa-miR-1274b_st   0.650599882 19:58024375-58024441 (−) 17 UCCCUGUUCGGGCGCCA  899 hsa-miR-1281_st −0.534051953 22:41488517-41488570 (+) 17 UCGCCUCCUCCUCUCCC  900 hsa-miR-1282_st  0.282040051 15:44085857-44085957 (−) 20 UCGUUUGCCUUUUUCUGCUU  901 hsa-miR-1284_st −0.066820239  3:71591121-71591240 (−) 22 UCUAUACAGACCCUGGCUUUUC  902 hsa-miR-1288_st  0.252079407 17:16185328-16185402 (+) 21 UGGACUGCCCUGAUCUGGAGA  903 hsa-miR-1292_st −0.42886343 20:2633423-2633488 (+) 25 UGGGAACGGGUUCCGGCAGACGCUG  904 hsa-miR-1252_st  0.250812674 12:79813037-79813101 (+) 22 AGAAGGAAAUUGAAUUCAUUUA  905 hsa-miR-1255b_st  0.349514198 22 CGGAUGAGCAAAGAAAGUGGUU  906 hsa-miR-1280_st −0.049084714  3:128081008-128081101 (+)  17 UCCCACCGCUGCCACCC  907 hsa-miR-1308_st  0.168161553  X:22080259-22080312 (−) 18 GCAUGGGUGGUUCAGUGG  908 hsa-miR-664- −0.356675666  1:220373880-220373961 (−) 24 ACUGGCUAGGGAAAAUGAUUGGAU  909 star_st hsa-miR-664_st −0.205960725  1:220373880-220373961 (−) 23 UAUUCAUUUAUCCCCAGCCUACA  910 hsa-miR-1306_st −0.288724376 22:20073581-20073665 (+) 18 ACGUUGGCUCUGGUGGUG  911 hsa-miR-1307_st −0.60493163 10:105154010-105154158 (−) 22 ACUCGGCGUGGCGUCGGUCGUG  912 hsa-miR-513b_st −0.117368926  X:146280562-146280645 (−) 22 UUCACAAGGAGGUGUCAUUUAU  913 hsa-miR-513c_st −0.391776892  X:146271222-146271305 (−) 22 UUCUCAAGGAGGUGUCGUUUAU  914 hsa-miR-1321_st −0.430473503  X:85090785-85090863 (+) 18 CAGGGAGGUGAAUGUGAU  915 hsa-miR-1322_st −0.112231232  8:10682883-10682953 (−) 19 GAUGAUGCUGCUGAUGCUG  916 hsa-miR-720_st  0.023319864  3:164059129-164059238 (+) 17 UCUCGCUGGGGCCUCCA  917 hsa-miR-1197_st  0.090310683 14:101491901-101491988 (+) 21 UAGGACACAUGGUCUACUUCU  918 hsa-miR-1324_st  0.4334564  3:75679914-75680009 (+) 24 CCAGACAGAAUUCUAUGCACUUUC  919 hsa-miR-1469_st −0.470797377 15:96876490-96876536 (+) 22 CUCGGCGCGGGGCGCGGGCUCC  920 hsa-miR-1470_st −0.596380055 19:15560359-15560419 (+) 21 GCCCUCCGCCCGUGCACCCCG  921 hsa-miR-1471_st −0.38161882  2:232756952-232757008 (−) 22 GCCCGCGUGUGGAGCCAGGUGU  922 hsa-miR-1537_st  0.23022374  1:236016300-236016360 (−) 22 AAAACCGUCUAGUUACAGUUGU  923 hsa-miR-1538_st −0.165515652 16:69399711-69599771 (−)  23 CGGCCCGGGCUGCUGCUGUUCCU  924 hsa-miR-1519_st  0.003073749 18:47013743-47013792 (+) 21 UCCUGCGCGUCCCAGAUGCCC  925 hsa-miR-103- −0.241290715 23 UCAUAGCCCUGUACAAUGCUGCU  926 as_st hsa-miR-320d_st  0.038797836 19 AAAAGCUGGGUUGAGAGGA  927 hsa-miR-1825_st −0.383306722 20:30825598-30825650 (+) 18 UCCAGUGCCCUCCUCUCC  928 hsa-miR-1826_st −0.274083166 16:33965508-33965592 (+) 27 AUUGAUCAUCGACACUUCGAACGC  929 AAU hsa-miR-1827_st  1.177531932 12:100583662-100583727 (+) 18 UGAGGCAGUAGAUUGAAU  930 hsa-miR-1908_st −0.425800688 11:61582633-61582712 (−) 21 CGGCGGGGGACGGCGAUUGGUC  931 hsa-miR-1909- −0.653633397 19:1816158-1816237 (−) 21 UGAGUGCCGGUGCCUGCCCUG  932 star_st hsa-miR-1909_st −0.507939701 19:1816158-1816237 (−) 22 CGCAGGGGCCGGGUGCUCACCG  933 hsa-miR-1910_st −1.031190911 16:85775227-85775306 (−) 21 CCAGUCCUGUGCCUGCCGCCU  934 hsa-miR-1911_st  0.078126657  X:113997744-113997823 (+) 23 UGAGUACCGCCAUGUCUGUUGGG  935 hsa-miR-1911-  0.100849161  X:113997744-113997823 (+) 20 CACCAGGCAUUGUGGUCUCC  936 star_st hsa-miR-1912_st  0.111721744  X:113886019-113886098 (+) 22 UACCCAGAGCAUGCAGUGUGAA  937 hsa-miR-1913_st −0.392395342  6:166922842-166922921 (−) 22 UCUGCCCCCUCCGCUGCUGCCA  938 hsa-miR-1914_st −0.30704752 20:62572818-62572897 (−) 22 CCCUGUGCCCGGCCCACUUCUG  939 hsa-miR-1914- −0.480039303 20:62572818-62572897 (−) 22 GGAGGGGUCCCGCACUGGGAGG  940 star_st hsa-miR-1915- −0.509178313 10:21785491-21785570 (−) 22 ACCUUGCCUUGCUGCCCGGGCC  941 star_st hsa-miR-1915_st −0.437756775 10:21785491-21785570 (−) 20 CCCCAGGGCGACGCGGCGGG  942 hsa-miR-1972_st −0.200757156 22 UCAGGCCAGGCACAGUGGCUCA  943 hsa-miR-1973_st  0.248567729  4:117220881-117220924 (+) 19 ACCGUGCAAAGGUAGCAUA  944 hsa-miR-1975_st −0.221811549  7:148638580-198638654 (+) 25 CCCCCACAACCGCGCUUGACUAGCU  945 hsa-miR-1976_st −0.631313814   1:26881033-26881084 (+) 20 CCUCCUGCCCUCCUUGCUGU  946 hsa-miR-1979_st −0.254099361  4:166321814-166321889 (−) 22 CUCCCACUGCUUCACUUGACUA  947 hsa-miR-2052_st  0.617914743  8:75617928-75617982 (+) 20 UGUUUUGAUAACAGUAAUGU  948 hsa-miR-2053_st  0.205633242  8:113655722-113655812 (+) 23 GUGUAAUAUAAACCUCUAUUUAC  949 hsa-miR-2054_st  0.31658574  4:126428414-126418462 (+) 22 CUGUAAUAUAAAUUUAAUUUAUU  950 hsa-miR-2110_st −0.438297349 10:115933864-115933938 (−) 22 UUGGGGAAACGGCCGCUGAGUG  951 hsa-miR-2114_st  0.377747857  X:149396239-149396318 (+) 22 UAGUCCCUUCCUUGAAGCGGUC  952 hsa-miR-2114-  0.197327215  X:149396239-149396318 (+) 21 CGAGCCUCAAGCAAGGGACUU  953 star_st hsa-miR-2115_st  0.356015555  3:48357850-48357949 (−) 22 AGCUUCCAUGACUCCUGAUGGA  954 hsa-miR-2115- −0.350063425  3:48357850-48357949 (−) 22 CAUCAGAAUUCAUGGAGGCUAG  955 star_st hsa-miR-2116_st −0.081615979 15:59463382-59463461 (−)  21 GGUUCUUAGCAUAGGAGGUCU  956 hsa-miR-2116-  0.257021767 15:59463382-59463461 (−)  21 CCUCCCAUGCCAAGAACUCCC  957 star_st hsa-miR-2117_st −0.170797696 17:41522174-41522253 (+) 21 UGUUCUCUUUGCCAAGGACAG  958 hsa-miR-548q_st −0.077430639 10:12767253-12767352 (−) 22 GCUGGUGCAAAAGUAAUGGCGG  959 hsa-miR-2276_st −0.435089246 13:24736555-24736643 (+) 22 UCUGCAAGUGUCAGAGGCGAGG  960 hsa-miR-2277_st −0.600588355  5:92956402-92956494 (−) 21 UGACAGCGCCCUGCCUGGCUC  961 hsa-miR-2278_st −0.296445646  9:97572244-97572339 (+) 22 GAGAGCAGUGUGUGUUGCCUGG  962 hsa-miR-711_st −0.539452913  3:48616335-48616410 (−) 22 GGGACCCAGGGAGAGACGUAAG  963 hsa-miR-718_st −0.278782479  X:153285371-153285440 (−) 21 CUUCCGCCCCGCCGGGCGUCG  964 hsa-miR-2861_st −0.420131134  9:130548197-130548286 (+) 19 GGGGCCUGGCGGUGGGCGG  965 hsa-miR-2909_st  0.215130051 17:35391042-35391110 (+) 21 GUUAGGGCCAACAUCUCUUGG  966 hsa-miR-3115_st  0.158204368  1:23370798-23370865 (+) 20 AUAUGGGUUUACUAGUUGGU  967 hsa-miR-3116_st  0.148122118 22 UGCCUGGAACAUAGUAGGGACU  968 hsa-miR-3117_st  −0.025995803  1:67094123-61094200 (+) 21 AUAGGACUCAUAUAGUGCCAG  969 hsa-miR-3118_st  0.389328538 23 UGUGACUGCAUUAUGAAAAUUCU  970 hsa-miR-3119_st  0.084756445 20 UGGCUUUUAACUUUGAUGGC  971 hsa-miR-3120_st −0.350893422  1:172107948-172108028 (+) 21 CACAGCAAGUGUAGACAGGCA  972 hsa-miR-3121_st −0.140416111  1:180407449-180407525 (−) 22 UAAAUAGAGUAGGCAAAGGACA  973 hsa-miR-3122_st −0.592901474  1:212250955-212251027 (+) 22 GUUGGGACAAGAGGACGGUCUU  974 hsa-miR-3123_st −0.99978109  1:241295572-241295646 (+) 17 CAGAGAAUUGUUUAAUC  975 hsa-miR-3124_st −0.555102495  1:249120576-249120642 (+) 21 UUCGCGGGCGAAGGCAAAGUC  976 hsa-miR-548s_st  0.223477901  2:11907570-11907651 (+) 23 AUGGCCAAAACUGCAGUUAUUUU  977 hsa-miR-3125_st −0.057958131  2:12877493-12877570 (+) 20 UAGAGGAAGCUGUGGAGAGA  978 hsa-miR-3126- −0.326534467  2:69330814-69330887 (+) 22 UGAGGGACAGAUGCCAGAAGCA  979 5p_st hsa-miR-3126- −0.03094953  2:69330814-69330887 (+) 22 CAUCUGGCAUCCGUCACACAGA  980 3p_st hsa-miR-3127_st −0.256018018  2:97464015-97464090 (+) 23 AUCAGGGCUUGUGGAAUGGGAAG  981 hsa-miR-3128_st −0.157486124  2:178120673-178120738 (−) 23 UCUGGCAAGUAAAAAACUCUCAU  982 hsa-MiR-3129_st −0.209599553  2:189997762-189997837 (−) 22 GCAGUAGUGUAGAGAUUGGUUU  983 hsa-miR-3130- −0.252446104 21 UACCCAGUCUCCGGUGCAGCC  984 5p_st hsa-miR-3130- −0.538355669 21 GCUGCACCGGAGACUGGGUAA  985 3p_st hsa-miR-3131_st −0.502950205  2:219923410-219923472 (−) 23 UCGAGGACUGGUGGAAGGGCCUU  986 hsa-miR-3132_st −0.184592247  2:220413795-220413869 (−)  24 UGGGUAGAGAAGGAGCUCAGAGGA  987 hsa-miR-3133_st  0.324759964  2:242417320-242417397 (+) 22 UAAAGAACUCUUAAAACCCAAU  988 hsa-miR-378b_st −0.030689576  3:10371913-10371969 (+) 19 ACUGGACUUGGAGGCAGAA  989 hsa-miR-3134_st  0.098733552  3:15738805-15738878 (−) 23 UGAUGGAUAAAAGACUACAUAUU  990 hsa-miR-3135_st −0.442883908  3:20179057-20119133 (+) 22 UGCCUAGGCUGAGACUGCAGUG  991 hsa-miR-466_st −0.028270025  3:31203196-31203279 (−) 23 AUACACAUACACGCAACACACAU  992 hsa-miR-3136_st −0.190142604  3:69098109-69098186 (−) 23 CUGACUGAAUAGGUAGGGUCAUU  993 hsa-miR-544b_st −0.066212259  3:124451286-124451363 (+) 22 ACCUGAGGUUGUGCAUUUCUAA  994 hsa-miR-3137_st −0.548300574  3:194855235-194855309 (−) 24 UCUGUAGCCUGGGAGCAAUGGGGU  995 hsa-miR-3138_st −0.393980701  4:10080235-10080316 (−) 24 UGUGGACAGUGAGGUAGAGGGAGU  996 hsa-miR-3139_st −0.072638653  4:144264613-144264688 (+) 23 UAGGAGCUCAACAGAUGCCUGUU  997 hsa-miR-3140_st −0.149655043  4:153410479-153410568 (−) 22 AGCUUUUGGGAAUUCAGGUAGU  998 hsa-miR-548t_st  0.430239948  4:174189311-174189384 (+) 21 CAAAAGUGAUCGUGGUUUUUG  999 hsa-miR-3141_st −0.544811704  5:153975572-153975632 (−) 19 GAGGGCGGGUGGAGGAGGA 1000 hsa-miR-3142_st  0.17358407  5:159901409-159901490 (+)   22 AAGGCCUUUCUGAACCUUCAGA 1001 hsa-miR-3143_st  0.185111272  6:27115405-27115467 (+) 25 AUAACAUUGUAAAGCGCUUCUUUCG 1002 hsa-miR-548u_st  0.67348033  6:57254930-57255010 (+) 23 CAAAGACUGCAAUUACUUUUGCG 1003 hsa-miR-3144-  0.361121329  6:120336325-120336403 (+) 22 AGGGGACCAAAGAGAUAUAUAG 1004 5p_st hsa-miR-3144-  0.350242292  6:120336325-120336403 (+) 22 AUAUACCUGUUCGGUCUCUUUA 1005 3p_st hsa-miR-3145_st  0.424206114   6:138756350-138756431 (−) 24 AGAUAUUUUGAGUGUUUGGAAUUG 1006 hsa-miR- −0.192757992  6:155174494-155174570 (+) 22 GGCGACAAAACGAGACCCUGUC 1007 1273c_st hsa-miR-3146_st −0.038088065  7:19744981-19745059 (−) 22 CAUGCUAGGAUAGAAAGAAUGG 1008 hsa-miR-3147_st −0.410906459  7:57472731-57472796 (+) 24 GGUUGGGCAGUGAGGAGGGUGUGA 1009 hsa-miR-548v_st  0.284062501  8:17539087-17539166 (−) 22 AGCUACAGUUACUUUUGCACCA 1010 hsa-miR-3148_st −0.283630101  8:29814788-29814864 (−) 22 UGGAAAAAACUGGUGUGUGCUU 1011 hsa-miR-3149_st  0.10201604  8:77879004-77879086 (−) 23 UUUGUAUGGAUAUGUGUGUGUAU 1012 hsa-miR-3150_st −0.557341627  8:96085142-96085221 (+) 22 CUGGGGAGAUCCUCGAGGUUGG 1013 hsa-miR-3151_st −0.63578655  8:104166842-104166917 (+) 21 GGUGGGGCAAUGGGAUCAGGU 1014 hsa-miR-3152_st −0.312469277  9:18573304-18573377 (+) 22 UGUGUUAGAAUAGGGGCAAUAA 1015 hsa-miR-3153_st −0.477067448  9:91927140-91927221 (+) 23 GGGGAAAGCGAGUAGGGACAUUU 1016 hsa-miR-3074_st −0.403860082  9:97848296-97848376 (−) 22 GAUAUCAGCUCAGUAGGCACCG 1017 hsa-miR-3154_st −0.411809229  9:131007226-131007309 (−) 22 CAGAAGGGGAGUUGGGAGCAGA 1018 hsa-miR-3155_st  −0.155939504 10:6194159-6194240 (+) 21 CCAGGCUCUGCAGUGGGAACU 1019 hsa-miR-3156_st  0.145082826 22 AAAGAUCUGGAAGUGGGAGACA 1020 hsa-miR-3157_st −0.286881084 10:97824072-97824156 (−) 22 UUCAGCCAGGCUAGUGCAGUCU 1021 hsa-miR-3158_st  0.038133672 22 AAGGGCUUCCUCUCUGCAGGAC 1022 hsa-miR-3159_st  −0.238871967 11:18409334-18409407 (+) 22 UAGGAUUACAAGUGUCGGCCAC 1023 hsa-miR-3160_st  0.217559091 22 AGAGCUGAGACUAGAAAGCCCA 1024 hsa-miR-3161_st  0.046100674 11:48118334-48118410 (+) 23 CUGAUAAGAACAGAGGCCCAGAU 1025 hsa-miR-3162_st −0.452127683 11:59362550-59362631 (−) 23 UUAGGGACUAGAAGGGUGGGGAG 1026 hsa-miR-3163_st −0.155224654 11:66701905-66701977 (−) 22 UAUAAAAUGAGGGCAGUAAGAC 1027 hsa-miR-3164_st  0.026347417 11:68850644-68850726 (+) 22 UGUGACUUUAAGGGAAAUGGCG 1028 hsa-miR-3165_st −0.34715416 11:71783274-71783348 (−) 22 AGGUGGAUGCAAUGUGACCUCA 1029 hsa-miR-3166_st  0.144398541 11:87909670-87909761 (+) 23 CGCAGACAAUGCCUACUGGCCUA 1030 hsa-miR-  0.056152106 11:96074602-96074690 (+) 19 AUCCCACCACUGCCACCAU 1031 1260b_st hsa-miR-3167_st  0.046061902 11:126858354-126858438 (−) 22 AGGAUUUCAGAAAUACUGGUGU 1032 has-miR-3168_st −0.043290328 13:41675155-41675236 (−) 17 GAGUUCUACAGUCAGAC 1033 has-miR-3169_st −0.022725278 13:61773932-61774014 (−) 22 UAGGACUGUGCUUGGCACAUAG 1034 hsa-miR-3170_st −0.228412507 13:98860778-98860854 (+) 22 CUGGGGUUCUGAGACAGACAGU 1035 hsa-miR-3171_st −0.327109797 14:28102411-28102484 (−) 24 AGAUGUAUGGAAUCUGUAUAUAUC 1036 hsa-miR-3172_st −0.193826153 14:32954301-32954379 (+) 19 UGGGGUUUUGCAGUCCUUA 1037 hsa-miR-3173_st −0.283616732 14:95604256-95604323 (−) 22 AAAGGAGGAAAUAGGCAGGCCA 1038 hsa-miR-1193_st −0.10471872 14:101496389-101496466 (+) 23 GGGAUGGUAGACCGGUGACGUGC 1039 hsa-miR-323b- −0.229066875 14:101522556-101522637 (+) 23 AGGUUGUCCGUGGUGAGUUCGCA 1040 5p_st hsa-miR-323b-  0.508572443 14:101522556-101522637 (+) 22 CCCAAUACACGGUCGACCUCUU 1041 3p_st hsa-miR-3174_st  0.000583267 15:90349987-90550073 (+) 23 UAGUGAGUUAGAGAUGCAGAGCC 1042 hsa-miR-3175_st −0.155279288 15:93447629-93447705 (+) 22 CGGGGAGAGAACGCAGUGACGU 1043 hsa-miR-3176_st  0.040745882 16:593277-593366 (+) 19 ACUGGCCUGGGACUACCGG 1044 hsa-miR-3177_st −0.41569559 16:1784986-1785067 (+) 21 UGCACGGCACUGGGGACACGU 1045 hsa-miR-3178_st −0.399033874 16:2581925-2582006 (−) 17 GGGGCGCGGCCGGAUCG 1046 hsa-miR-3179_st −0.339389507 22 AGAAGGGGUGAAAUUUAAACGU 1047 hsa-miR-3180- −0.642017769 25 CUUCCAGACGCUCCGCCCCACGUCG 1048 5p_st hsa-miR-3180- −0.720010774 22 UGGGGCGGAGCUUCCGGAGGCC 1049 3p_st hsa-miR-548w_st −0.221954829 16:26036558-26036631 (+) 23 AAAAGUAACUGCGGUUUUUGCCU 1050 hsa-miR-3181_st −0.477664644 16:50776216-50776288 (+) 19 AUCGGGCCCUCGGCGCCGG 1051 hsa-miR-3182_st  0.068447773 16:83541951-83542013 (+) 17 GCUUCUGUAGUGUAGUC 1052 hsa-miR-3183_st −0.022834953 17:925716-925799 (−) 22 GCCUCUCUCGGAGUCGCUCGGA 1053 hsa-miR-3184_st −0.381752425 17:28444104-28444178 (−) 24 UGAGGGGCCUCAGACCGAGCUUUU 1054 hsa-miR-3185_st −0.67158713 17:46801770-46801837 (−) 23 AGAAGAAGGCGGUCGGUCUGCGG 1055 hsa-miR-3065-  1.258036846 17:79099677-79099755 (+) 23 UCAACAAAAUCACUGAUGCUGGA 1056 5p_st hsa-miR-3065-  0.81022744 17:79099677-79099755 (+) 23 UCAGCACCAGGAUAUUGUUGGAG 1057 3p_st hsa-miR-3186-  0.136863218 17:79418130-79418214 (−) 22 CAGGCGUCUGUCUACGUGGCUU 1058 5p_st hsa-miR-3186- −0.28100309 17:79418130-79418214 (−) 21 UCACGCGGAGAGAUGGCUUUG 1059 3p_st hsa-miR-3187_st −0.65937084 19:813584-813653 (+) 20 UUGGCCAUGGGGCUGCGCGG 1060 hsa-miR-3188_st −0.588548166 19:18392887-18392971 (+) 23 AGAGGCUUUGUGCGGAUACGGGG 1061 hsa-miR-3189_st −0.411248984 19:18497372-18497444 (+) 21 CCCUUGGGUCUGAUGGGGUAG 1062 hsa-miR-320e_st −0.061648408 19:47212550-47212602 (−) 18 AAAGCUGGGUUGAGAAGG 1063 hsa-miR-3190- −0.255634524 19:47730199-47730278 (+) 23 UGUGGAAGGUAGACGGCCAGAGA 1064 5p_st hsa-miR-3190- −0.263953125 19:47730199-47730278 (+) 22 UGGAAGGUAGACGGCCAGAGAG 1065 3p_st hsa-miR-3191_st −0.217382811 19:47730201-47730276 (−) 23 UGGGGACGUAGCUGGCCAGACAG 1066 hsa-miR-3192_st −0.231668368 20:18451259-18451335 (+) 23 UCUGGGAGGUUGUACCAGUGGAA 1067 hsa-miR-3193_st −0.032326265 20:30194989-30195043 (+) 22 UCCUGCGUAGGAUCUGAGGAGU 1068 hsa-miR-3194_st −0.404916179 20:50069442-50069514 (−) 21 GGCCAGCCACCAGAGGGCUG 1069 hsa-miR-3195_st −0.584672209 20:60639858-60639941 (+) 17 CGCGCCGGGCCCGGGUU 1070 hsa-miR-3196_st −0.412279642 20:61870131-61870194 (+) 18 CGGGGCGGCAGGGGCCUC 1071 hsa-miR-548x_st  0.16197379 21:20058408-20058482 (−) 21 UAAAAACUGCAAUUACUUUCA 1072 hsa-miR-3197_st −0.248571382 21:42539484-42539556 (+) 23 GGAGGCGCAGGCUCGGAAAGGCG 1073 hsa-miR-3198_st −0.555869902 22:18246946-18247025 (−) 22 GUGGAGUCCUGGGGAAUGGAGA 1074 hsa-miR-3199_st −0.146392966 23 AGGGACUGCCUUAGGAGAAAGUU 1075 hss-miR-3200_st  0.718370764 22:31127544-31127628 (+) 22 CACCUUGCGCUACUCAGGUCUG 1076 hsa-miR-3201_st −0.418632783 22:48670176-48670227 (+) 17 GGGAUAUGAAGAAAAAU 1077 hsa-miR-514b- −0.373860947  X:146331669-146331748 (−)  22 UUCUCAAGAGGGAGGCAAUCAU 1078 5p_st hsa-miR-514b-  0.375642672  X:146331669-146331748 (−)  21 AUUGACACCUCUGUGAGUGGA 1079 3p_st hsa-miR-3202_st −0.22165488 22 UGGAAGGGAGAAGAGCUUUAAU 1080 hsa-miR- −0.246540664  1:10287776-10287861 (+) 25 GAACCCAUGAGGUUGAGGCUGCAGU 1081 1273d_st hsa-miR-4295_st  0.200141414 10:114393929-114394013 (+) 18 CAGUGCAAUGUUUUCCUU 1082 hsa-miR-4296_st −0.630156939 10:126721352-126721439 (−) 17 AUGUGGGCUCAGGCUCA 1083 hsa-miR-4297_st  0.079300954 10:131641563-131641638 (−) 16 UGCCUUCCUGUCUGUG 1084 hsa-miR-378e_st  0.141493059 10:132760851-132760931 (−) 25 ACUGGACUUGGAGUCAGAAGAGUGG 1085 hsa-miR-4293_st  0.126162345 10:14425199-14925276 (−) 17 CAGCCUGACAGGAACAG 1086 hsa-miR-4294_st −0.276095962 10:50193557-50193632 (−) 17 GGGAGUCUACAGCAGGG 1087 hsa-miR-4301_st −0.094108767 11:113320745-113320810 (−) 20 UCCCACUACUUCACUUGUGA 1088 hsa-miR-4299_st  0.196050419 11:11678198-11678269 (−) 18 GCUGGUGACAUGAGAGGC 1089 hsa-miR-4298_st −0.256083264 11:1880694-1880766 (−) 22 CUGGGACAGGAGGAGGAGGCAG 1090 hsa-miR-4300_st −0.491785636 11:81601783-81601878 (−) 18 UGGGAGCUGGACUACUUC 1091 hsa-miR-4304_st −0.092297363 12:123495214-123495275 (−) 17 CCGGCAUGUCCAGGGCA 1092 hsa-miR-4302_st −0.039688413 12:26026953-26027012 (−) 18 CCAGUGUGGCUCAGCGAG 1093 hsa-miR-4303_st  0.19446374 12:98389161-98389226 (−)  17 UUCUGAGCUGAGGACAG 1094 hsa-miR-4305_st −0.240743153 13:40238171-40238272 (−) 18 CCUAGACACCUCCAGUUC 1095 hsa-miR-4306_st −0.051694064 13:100295313-100295403 (+) 17 UGGAGAGAAAGGCAGUA 1096 hsa-miR-4309_st  0.127149097 14:103005981-103006063 (+) 18 CUGGAGUCUAGGAUUCCA 1097 hsa-miR-4307_st  0.326413052 14:27377848-27377931 (+) 19 AAUGUUUUUUCCUGUUUCC 1098 hsa-miR-4308_st  0.593586623 14:55344831-55344911 (−) 18 UCCCUGGAGUUUCUUCUU 1099 hsa-miR-4310_st  0.575886605 15:42158693-42158749 (−) 16 GCAGCAUUCAUGUCCC 1100 hsa-miR-4311_st −0.283666111 15:66332571-66332670 (+) 18 GAAAGAGAGCUGAGUGUG 1101 hsa-miR-4312_st −0.344771543 15:69094189-69094264 (−) 19 GGCCUUGUUCCUGUCCCCA 1102 hsa-miR-4313_st −0.28819078 15:76054556-76054656 (−) 20 AGCCCCCUGGCCCCAAACCC 1103 hsa-miR-4315_st  0.437871294 18 CCGCUUUCUGAGCUGGAC 1104 hsa-miR-4316_st −0.406166064 17:75393066-75393136 (−) 17 GGUGAGGCUAGCUGGUG 1105 hsa-miR-4314_st −0.264898682 17:7991374-7991465 (+) 18 CUCUGGGAAAUGGGACAG 1106 hsa-miR-4318_st −0.04902337 18:35237098-35237178 (+) 17 CACUGUGGGUACAUGCU 1107 hsa-miR-4319_st −0.180180524 18:42550047-42550131 (−) 17 UCCCUGAGCAAAGCCAC 1108 hsa-miR-4320_st −0.115193904 18:47652869-47652933 (−) 18 GGGAUUCUGUAGCUUCCU 1109 hsa-miR-4317_st  0.194590584 18:6374360-6374424 (−) 17 ACAUUGCCAGGGAGUUU 1110 hsa-miR-4322_st −0.669816339 19:10341089-10341161 (+) 21 CUGUGGGCUCAGCGCGUGGGG 1111 hsa-miR-4321_st −0.846697098 19:2250638-2250717 (+) 21 UUAGCGGUGGACCGCCCUGCG 1112 hsa-miR-4323_st −0.181143271 19:42637597-42637665 (−) 18 CAGCCCCACAGCCUCAGA 1113 hsa-miR-4324_st  0.244952427 19:49812054-49812125 (−) 20 CCCUGAGACCCUAACCUUAA 1114 hsa-miR-4256_st −0.264327488  1:113004392-113004455 (−) 18 AUCUGACCUGAUGAAGGU 1115 hsa-miR-4257_st −0.472791231  1:150524405-150524490 (+) 18 CCAGAGGUGGGGACUGAG 1116 hsa-miR-4258_st −0.545130693  1:154948169-154948259 (+) 17 CCCCGCCACCGCCUUGG 1117 hsa-miR-4259_st −0.53303471  1:159869769-159869869 (−) 22 CAGUUGGGUCUAGGGGUCAGGA 1118 hsa-miR-4260_st −0.308889731  1:209796789-209796855 (−) 19 CUUGGGGCAUGGAGUCCCA 1119 hsa-miR-4253_st −0.667912661  1:23189652-23189719 (−) 18 AGGGCAUGUCCAGGGGGU 1120 hsa-miR-4251_st −0.130602414  1:3044539-3044599 (+) 17 CCUGAGAAAAGGGCCAA 1121 hsa-miR-4254_st −0.043967396  1:32224261-32224336 (−) 23 GCCUGGAGCUACUCCACCAUCUC 1122 hsa-miR-4255_st −0.020830263  1:37627164-37627235 (+)  17 CAGUGUUCAGAGAUGGA 1123 hsa-miR-4252_st −0.057427141  1:6489894-6489956 (−) 19 GGCCACUGAGUCAGCACCA 1124 hsa-miR-4325_st  0.265406105 20:55896558-55896647 (−) 18 UUGCACUUGUCUCAGUGA 1125 hsa-miR-4326_st  0.006635041 20:61918160-61918218 (+) 20 UGUUCCUCUGUCUCCCAGAC 1126 hsa-miR-4327_st −0.64185473 21:31747612-31747696 (−) 19 GGCUUGCAUGGGGGACUGG 1127 hsa-miR-4261_st  0.03213025  2:10332740-10332797 (−) 16 AGGAAACAGGGACCCA 1128 hsa-miR-4265_st −0.144983092  2:109757946-109758044 (−) 19 CUGUGGGCUCAGCUCUGGG 1129 hsa-miR-4266_st −0.67079355  2:109930027-109930081 (−) 16 CUAGGAGGCCUUGGCC 1130 hsa-miR-4267_st   0.001682038  2:110827538-110827619 (−) 16 UCCAGCUCGGUGGCAC 1131 hsa-miR-4262_st  0.150034332  2:11977059-11977112 (−) 17 GACAUUCAGACUACCUG 1132 hsa-miR-2355_st  0.311136818  2:207974711-207974797 (−) 21 AUCCCCAGAUACAAUGGACAA 1133 hsa-miR-4268_st −0.251584982  2:220771223-220771286 (−) 21 GGCUCCUCCUCUCAGGAUGUG 1134 hsa-miR-4269_st −0.178058762  2:240227157-240227240 (+) 21 GCAGGCACAGACAGCCCUGGC 1135 hsa-miR-4263_st  0.41640847  2:28219234-28219316 (+) 18 AUUCUAAGUGCCUUGGCC 1136 hsa-miR-4264_st  0.175115529  2:79876420-79876485 (−) 17 ACUCAGACAUGGUCAUU 1137 hsa-miR-4270_st −0.502606734  3:15537746-15537815 (−) 20 UCAGGGAGUCAGGGGAGGGC 1138 hsa-miR-4271_st −0.446206505  3:49311553-49311619 (+) 19 GGGGGAAGAAAAGGUGGGG 1139 hsa-miR-4272_st −0.166774205  3:67275888-67275951 (+) 18 CAUUCAACUAGUGAUUGU 1140 hsa-miR-4273_st  0.128983317  3:75787431-75787514 (+) 18 GUGUUCUCUGAUGGACAG 1141 hsa-miR-4276_st  0.275823689  4:175344946-175345015 (+) 17 CUCAGUGACUCAUGUGC 1142 hsa-miR-4275_st −0.132958871  4:28821204-28821290 (+) 17 CCAAUUACCACUUCUUU 1143 hsa-miR-4274_st −0.229930196  4:7461755-7461845 (+) 18 CAGCAGUCCCUCCCCCUG 1144 hsa-miR-4281_st −0.516018376  5:176056440-176056501 (−) 18 GGGUCCCGGGGAGGGGGG 1145 hsa-miR-4277_st −0.074151462  5:1708900-1708983 (−) 21 GCAGUUCUGAGCACAGUACAC 1146 hsa-miR-4279_st −0.892166402  5:31936208-31936265 (−) 16 CUCUCCUCCCGGCUUC 1147 hsa-miR-4278_st −0.63517387  5:6827966-6828034 (−) 18 CUAGGGGGUUUGCCCUUG 1148 hsa-miR-4280_st  0.142387426  5:86410696-81410771 (−) 21 GAGUGUAGUUCUGAGCAGAGC 1149 hsa-miR-4282_st  0.153932894  6:73677410-73677476 (−) 18 UAAAAUUUGCAUCCAGGA 1150 hsa-miR-4285_st −0.648225861  7:101936369-101936453 (+) 18 GCGGCGACUCCGACUCAU 1151 hsa-miR-4283_st −0.754587333 17 UGGGGCUCAGCGAGUUU 1152 hsa-miR-4284_st  0.312303346  7:73125647-73125727 (+) 18 GGGCUCACAUCACCCCAU 1153 hsa-miR-4286_st  0.333955292  8:10524488-10524580 (+) 17 ACCCCACUCCUGGUACC 1154 hsa-miR-4287_st  0.328615626  8:27743556-27743633 (−) 19 UCUCCCUUGAGGGCACUUU 1155 hsa-miR-4288_st  1.017740413  8:28362633-28362699 (−) 17 UUGUCUGCUGAGUUUCC 1156 hsa-miR-4292_st −0.394930683  9:139725409-139725475 (+)  18 CCCCUGGGCCGGCCUUGG 1157 hsa-miR-4289_st  0.754785186  9:91360751-91360820 (−) 19 GCAUUGUGCAGGGCUAUCA 1158 hsa-miR-4290_st −0.682599288  9:92785723-92785817 (−) 19 UGCCCUCCUUUCUUCCCUC 1159 hsa-miR-4291_st  0.914392688  9:96581639-96581703 (+) 16 UUCAGCAGGAACAGCU 1160 hsa-miR-4329_st −0.123251977  X:112023946-112024016 (−) 19 CCUGAGACCCUAGUUCCAC 1161 hsa-miR-4330_st −0.381432698  X:150336694-150336798 (+) 19 CCUCAGAUCAGAGCCUUGC 1162 hsa-miR-500b_st  0.319409972  X:49775280-49775358 (+) 19 AAUCCUUGCUACCUGGGU 1163 hsa-miR-4328_st  0.221976157  X:78156691-78156746 (−) 17 CCAGUUUUCCCAGGAUU 1164

A total of 156 human miRNAs were significantly differentially expressed between the Benign and the Malignant groups of samples (p<0.05). Among these, 41 miRNAs were over-expressed (Log 2 diff (Malignant vs Benign)≥1) and 7 miRNAs were under-expressed (Log 2 diff (Malignant vs Benign)≤1) by at least 2-fold in the Malignant group compared to the Benign group of samples, with a p-value≤0.05. Of the miRNAs that were over-expressed, hsa-miR-146b was over-expressed by more than 15-fold in Malignant vs Norm, and hsa-miR-221*, -375, and -31* were over-expressed by more than 5-fold in the Malignant group of lesions compared to the Benign group of specimens (Tables 5A-C). In addition, hsa-miR-31*, -146b-3p, -21, -222, -221, -551b, -34a, and -31, were 3- to 5-fold overexpressed in Malignant lesions compared to Benign specimens (Tables 5A-C). Among the miRNAs that were under-expressed, hsa-miR-7 was under-expressed in the Malignant group by more than 4-fold compared to the Benign group of samples (Tables 5A-C).

TABLE 5A miRNAs significantly differentially expressed between the groups of Benign and Malignant samples. AVG SD AVE SD Fold ProbeSet benign benign malignant malignant change P-Value hsa-miR-146b-5p st 8.65 2.78 12.65 3.18 16.0 1.31E−05 hsa-miR-221-star st 5.35 2.24 8.07 1.85 6.6 8.79E−06 hsa-miR-375 st 4.40 1.60 6.83 3.47 5.4 3.40E−03 hsa-miR-31-star st 2 22 1.96 4.61 3.02 5.2 1.77E−03 hsa-miR-146B-3p st 3.91 1.05 6.12 2.62 4.6 5.30E−04 hsa-miR-21 st 10.51 2.21 12.68 1.67 4.5 1.21E−04 hsa-miR-222 st 11.66 2.08 13.62 1.51 3.9 1.69E−04 hsa-miR-221 sT 11.92 1.95 13.82 1.52 3.7 1.60E−04 hsa-miR-551b st 2.24 2.08 4.13 3.20 3.7 1.67E−02 hsa-miR-34a st 8.64 1.94 10.28 1.97 3.1 3.28E−03 hsa-miR-31 st 8.52 2.09 10.15 2.63 3.1 1.72E−02 hsa-miR-24-2-star st 4.62 1.71 6.16 1.55 2.9 9.67E−04 hsa-miR-34a-star st 4.95 1.10 6.46 1.37 2.8 6.97E−05 hsa-miR-146a st 8.00 2.54 9.49 1.68 2.8 1.18E−02 hsa-miR-340 st 2.76 2.00 4.25 1.89 2.8 6.87E−03 hsa-miR-301a st 3.05 2.12 4.53 2.02 2.8 1.10E−02 hsa-miR-34b-star st 3.84 1.38 5.22 2.09 2.6 8.17E−03 hsa-miR-142-5p st 3.36 2.36 4.71 2.03 2.6 2.66E−02 hsa-miR-425 st 7.68 1.89 9.00 1.47 2.5 5.10E−03 hsa-miR-27a st 1122 2.32 12.53 1.27 2.5  104E−02 hsa-miR-335 st 7.35 2.25 8.64 2.36 2.4 4.59E−02 hsa-miR~I82 si 7.85 2.08 9.12 2.02 2.4 2.75E−02 hsa-miR-3065-5p st 2.93 1.55 4.18 1.70 2.4 6.83E−03 hsa-miR-376c st 3.57 1.13 4.79 1.87 2.3 7.57E−03 hsa-miR-181a-star st 4.45 1.39 5.66 1.91 2.3 1.20E−02 hsa-miR-10b st 8.30 2.39 9.49 1.36 2.3 2.36E−02 hsa-miR-1827 st 4.49 1.20 5.67 1.27 2.3 1.08E−03 hsa-miR-493-star st 3.11 0.84 4.28 0.83 2 2 4.24E−06 hsa-miR-24-1-star st 2.80 1.64 3.95 1.95 2.2 2.45E−02 hsa-miR-329 st 2.75 1.08 3.88 1.62 2 2 5.44E−03 hsa-miR-140-5p st 4.09 1.54 5.22 2.06 2.2 3.04E−02 hsa-miR-15a st 9.52 2.07 10.63 158 2.2 2.87E−02 hsa-miR-1274a st 9.87 1.23 10.95 1.09 2.1 1.04E−03 hsa-miR-132 st 6.10 2.05 7.16 1.50 2.1 3.02E−02 hsa-miR-4288 st 3.91 1.23 4.93 1.09 2.0 2.11E−03 hsa-miR-181 st 7.71 1.79 8.73 1.83 2.0 4.52E−02 hsa-miR-495 st 2.34 1.29 3.34 2.10 2.0 4.72E−02 hsa-miR-196a_st 2.21 1.15 3.20 1.14 2.0 2.40E−03 hsa-miR-132-star_st 2.37 1.49 3.37 1.63 2.0 2.38E−02 hsa-miR-224_st 6.11 1.45 7.10 1.40 2.0 1.32E−02 hsa-miR-27b-star_st 5.70 1.28 6.69 1.38 2.0 9.13E−03 hsa-miR-487b_st 6.65 1.50 7.61 1.46 1.9 2.10E−02 hsa-miR-338-5p_st 4.60 1.17 5.53 1.22 1.9 6.12E−03 hsa-miR-4291_st 5.57 1.57 6.48 1.28 1.9 2.10E−02 hsa-miR-21-star_st 5.81 0.92 6.72 1.06 1.9 1.58E−03 hsa-miR-18a_st 4.14 1.10 5.03 1.26 1.9 8.62E−03 hsa-miR-16-2-star_st 3.10 1.35 3.99 1.34 1.9 1.83E−02 hsa-miR-99a-star_st 4.07 1.47 4.95 1.27 1.8 2.11E−02 hsa-miR-24_st 12.73 1.68 13.61 1.13 1.8 2.44E−07 hsa-miR-369-5p_st 2.91 1.00 3.76 1.57 1.8 2.55E−02 hsa-miR-146a-star_st 0.60 1.29 1.44 1.31 1.8 2.13E−02 hsa-miR-3065-3p_st 3.81 1.65 4.62 1.29 1.8 4.64E−02 hsa-miR-222-star_st 5.73 0.98 6.53 1.32 1.7 1.68E−02 hsa-miR-302b_st −0.26 1.16 0.54 1.42 1.7 2.95E−02 hsa-miR-202-star_st −0.78 0.78 −0.01 1.24 1.7 1.10E−02 hsa-miR-452_st 5.78 1.01 6.55 1.27 1.7 1.97E−02 hsa-miR-890_st 5.26 1.20 6.02 1.07 1.7 1.64E−02 hsa-miR4289_st 5.48 1.39 6.23 0.91 1.7 1.89E−02 hsa-miR-186-star_st 0.09 0.77 0.84 1.02 1.7 4.56E−03 hsa-miR-16-1-star_st 3.00 1.07 3.74 0.98 1.7 9.93E−03 hsa-miR-3200_st 3.15 0.90 3.87 1.25 1.6 2.24E−02 hsa-miR-539_st 3.11 0.94 3.80 1.39 1.6 4.42E−02 hsa-miR-548u_st 1.15 1.00 1.83 1.11 1.6 2.38E−02 hsa-miR-578_st 2.87 1.03 3.53 0.99 1.6 1.95E−02 hsa-miR-376a_st 3.31 0.98 3.97 1.12 1.6 2.76E−02 hsa-miR-582-5p_st 0.88 1.27 1.53 1.09 1.6 4.51E−02 hsa-miR-1274b_st 13.41 0.98 14.06 0.79 1.6 8.53E−03 hsa-miR-323-3p_st 3.30 0.82 3.92 0.95 1.5 1.47E−02 hsa-miR-181c-star_st 6.15 1.12 6.75 1.03 1.5 4.50E−02 hsa-miR-196a-star_st 4.14 1.05 4.71 0.79 1.5 2.42E−02 hsa-miR-642_st 3.02 0.93 3.52 0.86 1.4 4.66E−02 hsa-miR-1293_st 7.78 0.67 7.44 0.53 1.3 4.06E−02 hsa-miR-1303_st 10.51 0.68 10.16 0.58 1.3 4.68E−02 hsa-miR-770-5p_st 6.62 0.65 6.22 0.73 1.3 3.77E−02 hsa-miR-3147_st 11.26 0.56 10.85 0.60 1.3 1.23E−02 hsa-miR-363-star_st 10.16 0.69 9.74 0.58 1.3 1.75E−02 hsa-miR-1229_st 7.87 0.70 7.43 0.84 1.4 4.40E−02 hsa-miR-3135_st 6.39 0.72 5.95 0.66 1.4 2.09E−02 hsa-miR-423-5p_st 13.23 0.70 12.78 0.71 1.4 2.37E−02 hsa-miR-3153_st 9.39 0.67 8.92 0.73 1.4 1.61E−02 hsa-miR-296-3p_st 11.85 0.69 11.37 0.80 1.4 2.23E−02 hsa-miR-1180_st 9.65 0.72 9.17 0.86 1.4 2.92E−02 hsa-miR-1323_st 7.65 0.88 7.16 0.85 1.4 3.91E−02 hsa-miR-3131_st 11.92 0.76 11.41 0.97 1.4 4.21E−02 hsa-miR-1915-star_st 7.88 0.65 7.37 0.90 1.4 2.46E−02 hsa-miR-323-5p_st 11.03 0.85 10.52 0.98 1.4 4.77E−02 hsa-miR-194-star_st 8.34 0.90 7.83 0.85 1.4 3.37E−02 hsa-miR-658_st 12.09 0.83 11.56 1.05 1.4 4.81E−02 hsa-miR-4259_st 11.02 0.90 10.48 1.02 1.4 4.85E−02 hsa-miR-1281_st 9.16 0.89 8.63 1.03 1.4 4.92E−02 hsa-miR-3130-3p_st 7.73 0.88 7.19 1.05 1.5 4.96E−02 hsa-miR-302c-star_st 7.86 1.16 7.32 0.85 1.5 4.94E−02 hsa-miR-139-3p_st 7.69 0.83 7.15 1.00 1.5 3.56E−02 hsa-miR-1237_st 8.05 0.72 7.50 0.77 1.5 9.56E−03 hsa-miR-1181_st 9.91 0.84 9.36 0.62 1.5 6.70E−03 hsa-miR-3124_st 11.72 0.99 11.16 1.03 1.5 4.86E−02 hsa-miR-3150_st 9.40 0.89 8.84 1.06 1.5 4.45E−02 hsa-miR-449b-star_st 7.94 0.69 7.38 0.94 1.5 1.87E−02 hsa-miR-574-5p_st 7.92 0.55 7.35 1.16 1.5 3.65E−02 hsa-miR-920_st 10.32 0.89 9.75 1.03 1.5 3.35E−02 hsa-miR-939_st 13.40 0.82 12.82 1.03 1.5 2.91E−02 hsa-miR-92a-1-star_st 8.02 0.80 7.44 1.04 1.5 2.8711-02 hsa-miR-3195_st 12.82 0.94 12.24 1.13 1.5 4.71E−02 hsa-miR-1207-3p_st 3.97 0.72 3.38 0.80 1.5 6.57E−03 hsa-miR-616_st 7.54 0.62 6.95 0.77 1.5 3.66E−03 hsa-miR-1470_st 5.75 0.71 5.16 0.94 1.5 1.30E−02 hsa-miR-2277_at 8.84 0.83 8.24 0.97 1.5 1.93E−02 hsa-miR-1225-3p_st 8.02 1.07 7.42 0.97 1.5 3.19E−02 hsa-miR-769-3p_st 9.67 1.03 9.06 1.01 1.5 3.18E−02 hsa-miR-661_st 7.37 0.72 6.76 1.11 1.5 2.36E−02 hsa-miR-4296_at 7.28 0.76 6.64 1.08 1.5 1.94E−02 hsa-miR-1976_at 7.96 0.63 7.32 0.91 1.5 6.09E−03 hsa-miR-668_st 8.41 0.74 7.78 0.93 1.5 9.40E−03 hsa-miR-4278_at 6.86 1031 6.22 0.94 1.6 4.09E−02 hsa-miR-3151_st 11.33 0.82 10.69 0.97 1.6 1.31E−02 hsa-miR-4327_at 12.09 0.94 11.45 1.14 1.6 3.09E−02 hsa-miR-3180-5p_st 7.73 0.85 7.08 0.95 1.6 1.22E−02 hsa-miR-623_st 9.08 0.87 8.43 1.27 1.6 3.87E−02 hsa-miR-1909-star_st 9.07 0.67 8.42 0.84 1.6 3.27E−03 hsa-miR-3187_st 12.63 1.04 11.97 1.15 1.6 3.34E−02 hsa-miR-4253_st 11.25 0.89 10.59 1.27 1.6 3.48E−02 hsa-miR-639_st 8.84 0.96 8.17 1.16 1.6 2.70E−02 hsa-miR-4322_st 12.60 0.93 11.93 1.12 1.6 2.27E−02 hsa-miR-4266_st 6.15 0.81 5.48 0.99 1.6 1.01E−02 hsa-miR-760_st 10.58 0.85 9.91 0.90 1.6 6.89E−03 hsa-miR-197_st 7.75 0.62 7.06 1.04 1.6 6.58E−03 hsa-miR-637_st 12.60 0.95 11.90 1.06 1.6 1.48E−02 hsa-miR-1231_st 13.99 1.11 13.29 1.38 1.6 4.89E−02 hsa-miR-880-5p_st 12.24 0.69 11.53 1.43 1.6 3.20E−02 hsa-miR-3180-3p_st 14.82 1.09 14.10 1.09 1.6 1.86E−02 hsa-miR-346_st 9.25 0.69 8.52 0.81 1.7 8.64E−04 hsa-miR-935_st 6.68 1.03 5.93 1.06 1.7 1.21E−02 hsa-let-7b-star_st 7.05 0.74 6.30 1.01 1.7 3.93E−03 hsa-miR-193b-star_st 11.48 0.93 10.73 0.90 1.7 3.96E−03 hsa-miR-885-3p_st 13.74 1.10 12.99 1.15 17 1.79E−02 hsa-miR-4283_st 8.71 0.82 7.95 0.83 1.7 1.50E−03 hsa-miR-371-3p_st 4.50 1.38 3.74 1.19 1.7 3.09E−02 hsa-miR-548q_st 7.91 0.63 7.14 1.07 1.7 3.47E−03 hsa-miR-596_st 8.08 0.72 7.30 1.21 1.7 8.12E−03 hsa-miR-636_st 9.38 0.99 8.60 1.26 1.7 1.62E−02 hsa-miR-943_st 7.96 1.10 7.16 1.16 1.7 1.18E−02 hsa-miR-193a-5p_st 12.47 0.98 11.64 1.15 1.8 6.78E−03 hsa-miR-486-3p_st 10.16 1.03 9.32 1.22 1.8 9.94E−03 hsa-miR-4321_st 10.11 0.86 9.27 1.40 1.8 1.29E−02 hsa-miR-557_st 12.05 0.96 11.21 1.48 1.8 1.98E−02 hsa-miR-4279_st 5.63 0.83 4.74 1.36 1.9 7.48E−03 hsa-miR-138-1-star_st 7.63 1.09 6.72 1.46 1.9 1.47E−02 hsa-miR-373-star_st 11.18 1.23 10.26 1.38 1.9 1.42E−02 hsa-miR-885-5p_st 7.38 1.12 6.46 1.45 1.9 1.42E−02 hsa-miR-185-star_st 9.74 0.79 8.77 1.96 2.0 2.94E−02 hsa-miR-3123_st 0.81 1.05 −0.19 0.78 2.0 1.61E−04 hsa-miR-1910_st 10.20 0.67 9.17 1.01 2.0 1.04E−04 hsa-miR-139-5p_st 7.02 1.94 5.93 1.95 2.1 4.42E−02 hsa-miR-486-5p_st 8.82 1.57 7.68 1.27 2.2 4.53E−03 hsa-miR-519a_st 1.00 1.59 0.20 1.17 2.3 2.01E−03 hsa-miR-7_st 8.43 2.97 −6.27 3.78 4.5 2.62E−02 AVG, average expression among samples in a group; SD, standard deviation

TABLE 5B miRNAs significantly differentially expressed between the groups of Benign and Malignant samples. SEQ ID ProbeSet FDR Alignments Sequence NO: hsa-miR-146b-5p_st 0.005 10:104196269-1041956341 (+) UGAGAACUGAAUUCCAUAGGCU 3 hsa-miR-221-star_st 0.005 X:45605585-45605694 (−) ACCUGGCAUACAAUGUAGAUUU 7 hsa-miR-375_st 0.159 2:219866367-219866430 (−) UUUGUUCGUUCGGCUCGCGUGA 13 hsa-miR-31-star_st 0.114 9:21512114-21512184 (−) UGCUAUGCCAACAUAUUGCCAU 41 hsa-miR-146b-3p_st 0.058 10:104196269-104196341 (+) UGCCCUGUGGACUCAGUUCUGG 4 hsa-miR-21_st 0.021 17:57918627-57918698 (+) UAGCUUAUCAGACUGAUGUUGA 22 hsa-miR-222_st 0.021 X:45606421-45606530 (−) AGUACAUCUGGCUACUGGGU 31 hsa-miR-221_st 0.021 X:4560585-45605694 (−) AGCUACAUUGUCUGCUGGGUUUC 17 hsa-miR-51b_st 0.246 3:168269642-168269737 (+) GCGACCCAUACUUGGUUUCAG 54 hsa-miR-34a_st 0.159 1:9211727-9211836 (−) UGGCAGUGUCUUAGCUGGUUGU 23 hsa-miR-31_st 0.250 9:21512114-21512184 (−) AGGCAAGAUGCUGGCAUAGCU 18 hsa-miR-24-2-star_st 0.085 UGCCUACUGAGCUGAAACACAG 38 hsa-miR-34a-star_st 0.019 1:9211727-9211836 (−) CAAUCAGCAAGUAUACUGCCCU 42 hsa-miR-146a_st 0.221 5:159912359-159912457 (+) UGAGAACUGAAUUCCAUGGGUU 34 hsa-miR-340_st 0.189 5:179442303-179442397 (−) UUAUAAAGCAAUGAGACUGAUU 53 hsa-miR-301a_st 0.221 17:57228497-57228582 (−) CAGUGCAAUAGUAUUGUCAAAGC 51 hsa-miR-34b-star_st 0.204 11:111383663-111383746 (+) UAGGCAGUGUCAUUAGCUGAUUG 43 hsa-miR-142-5p_st 0.274 17:56408593-56408679 (−) CAUAAAGUAGAAAGCACUACU 46 hsa-miR-425_st 0.187 3:49057581-49057667 (−) AAUGACACGAUCACUCCCGUUGA 33 hsa-miR-27a_st 0.215 19:13947254-13947331 (−) UUCACAGUGGCUAAGUUCCGC 39 hsa-miR-335_st 0.350 7:130135952-130136045 (+) UCAAGAGCAAUAACGAAAAAUGU 52 hsa-miR-182_st 0.276 7:129410223-129410332 (−) UUUGGCAAUGGUAGAACUCACACU 49 hsa-miR-3065-5p_st 0.189 17:79099677-79099755 (+) UCAACAAAAUCACUGAUGCUGGA 56 hsa-miR-376c_st 0.198 14:101506027-101506092 (+) AACAUAGAGGAAAUUCCACGU 11 hsa-miR-181a-star_st 0.221 ACCAUCGACCGUUGAUUGUACC 47 hsa-miR-10b_st 0.261 2:177015031-177015140 (+) UACCCUGUAGAACCGAAUUUGUG 35 hsa-miR-1827_st 0.085 12:100583662-100583727 (+) UGAGGCAGUAGAUUGAAU 55 hsa-miR-493-star_st 0.005 14:101335397-101335485 (+) UUGUACAUGGUAGGCUUUCAUU 19 hsa-miR-24-1-star_st 0.261 UGCCUACUGAGCUGAUAUCAGU 37 hsa-miR-329_st 0.189 AACACACCUGGUUAACCUCUUU 5 hsa-miR-140-5p_st 0.283 16:69966984-69967083 (+) CAGUGGUUUUACCCUAUGGUAG 250 hsa-miR-15a_st 0.280 13:50623255-50623337 (−) UAGCAGCACAUAAUGGUUUGUG 36 hsa-miR-1274a_st 0.085 5:41475734-41475804 (+) GUCCCUGUUCAGGCGCCA 64 hsa-miR-132_st 0.283 17:1953202-1953302 (−) UAACAGUCUACAGCCAUGGUCG 44 hsa-miR-4288_st 0.122 8:28362633-28362699 (−) UUGUCUGCUGAGUUUCC 57 hsa-miR-181c_st 0.350 19:13985513-13985622 (+) AACAUUCAACCUGUCGGUGAGU 48 hsa-miR-495_st 0.350 14:101500092-101500173 (+) AAACAAACAUGGUGCACUUCUU 9 hsa-miR-196a_st 0.132 UAGGUAGUUUCAUGUUGUUGGG 50 hsa-miR-132-star_st 0.261 17:1953202-1953302 (−) ACCGUGGCUUUCGAUUGUUACU 45 hsa-miR-224_st 0.223 X:151127050-151127130 (4 CAAGUCACUAGUGGUUCCGUU 32 hsa-miR-27b-star_st 0.214 9:97847727-97847823 (+) AGAGCUUAGCUGAUUGGUGAAC 40 hsa-miR-487b_st 0.255 14:101512792-101512875 (+) AAUCGUACAGGGUCAUCCACUU 557 hsa-miR-538-5p_st 0.189 17:79099683-79099749 (−) AACAAUAUCCUGGUGCUGAGUG 397 hsa-miR-4291_st 0.255 9:96581639-96581703 (441 UUCAGCAGGAACAGCU 1160 hsa-miR-21-star_st 0.109 17:57918627-57918698 (+) CAACACCAGUCGAUGGGCUGU 95 hsa-miR-18a_st 0.206 13:92003005-92003075 (+) UAAGGUGCAUCUAGUGCAGAUAG 85 hsa-miR-16-2-star_st  0.350 CCAAUAUUACUGUGCUGCUUUA 148 hsa-miR-99a-star_st 0.255 21:17911409-17911489 (+) CAAGCUCGCUUCUAUGGGUCUG 133 hsa-miR-24_st 0.261 UGGCUCAGUUCAGCAGGAACAG 101 hsa-miR-369-5p_st 0.267 14:101531935-101532004 (+) AGAUCGACCGUGUUAUAUUCGC 15 hsa-miR-146a-star_st 0.255 5:159912359-159912457 (+) CCUCUGAAAUUCAGUUCUUCAG 281 hsa-miR-3065-3p_st 0.350 17:79099677-79099755 (4) UCAGCACCAGGAUAUUGUUGGAG 1057 hsa-miR-222-star_st 0.146 X:45606421-45606530 (−) CUCAGUAGCCAGUGUAGAUCCU 14 hsa-miR-302b_st 0.180 4:113569641-113569713 (−) UAAGUGCUUCCAUGUUUAGUAG 343 hsa-miR-202-star_st 0.221 10:135061015-135061124 (−) UUCCUAUGCAUAUACUUCUUUG 455 hsa-miR-452_st 0.250 X:151128100-151128184 (−) AACUGUUUGGAGAGGAAACUGA 430 hsa-miR-890_st 0.246 X:145075793-145075869 (−) UACUUGGAAAGGCAUCAGUUG 753 hsa-miR-4289_st 0.250 9:91360751-91360820 (−) GCAUUGUGCAGGGCUAUCA 1158 hsa-miR-186-star_st 0.173 1:71533314-71533399 (−) GCCCAAAGGUGAAUUUUUUGGG 292 hsa-miR-16-1-star_st 0.214 CCAGUAUUAACUGUGCUGCUGA 82 hsa-miR-3200_st 0.261 22:31127544-31127628 (+) CACCUUGCGCUACUCAGGUCUG 21 hsa-miR-539_st 0.350 14:101513658-101513735 (+) GGAGAAAUUAUCCUUGGUGUGU 1 hsa-miR-548a_st 0.261 6:57254930-57255010 (+) CAAAGACUGCAAUUACUUUUGCG 1003 hsa-miR-578_st 0.250 4:166307394-166507489(f) CUUCUUGUGCUCUAGGAUUGU 590 hsa-miR-376a 81 0.276 AUCAUAGAGGAAAAUCCACGU 363 hsa-miR-582-511_st 0.350 5:58999432-58999529 (−) UUACAGUUGUUCAACCAGUUACU 594 hsa-miR-1274b_st 0.206 19:58024375-58024441 (−) UCCCUGUUCGGGCGCCA 899 hsa-miR-323-3p_st 0.232 14:101492069-101492154 (+) CACAUUACACGGUCGACCUCU 385 hsa-miR-181c-star_st 0.350 19:13985513-13985622 (+) AACCAUCGACCGUUGAGUGGAC 181 hsa-miR-196a-star_st 0.261 CGGCAACAAGAAACUGCCUGAG 188 hsa-miR-642_st 0.350 19:46178186-461782112 (+) GUCCCUCUCCAAAUGUGUCUUG 673 hsa-miR-1293_st 0.336 12:50627925-50627995 (−) UGGGUGGUCUGGAGAUUUGUGC 845 hsa-miR-1303_st 0.350 5:154065336-154065421 (+) UUUAGAGACGGGGUCUUGCUCU 852 hsa-miR-770-5p_st 0.319 14:101318727-101318824 (+) UCCAGUACCACGUGUCAGGGCCA 740 hsa-miR-3147_st 0.221 7:57472731-57472796 (+) GGUUGGGCAGUGAGGAGGGUGUGA 1009 hsa-miR-363-star_st 0.250 X:133303408-133303482 (−) CGGGUGGAUCACGAUGCAAUUU 338 hsa-miR-1229_st 0.350 5:179225278-179225346 (−) CUCUCACCACUGCCCUCCCACAG 818 hsa-miR-3135_st 0.255 3:20179057-20179133 (+) UGCCUAGGCUGAGACUGCAGUG 991 hsa-miR-423-5p_st 0.261 17:28444097-28444190 (+) UGAGGGGCAGAGAGCGAGACUUU 411 hsa-miR-3153_st 0.246 9:91927140-91927221 (+) GGGGAAAGCGAGUAGGGACAUUU 1016 hsa-miR-296-3p_st 0.261 20:57392670-57392749 (−) GAGGGUUGGGUGGAGGCUCUCC 328 hsa-miR-1180_st 0.280 17:19247819-19247887 (−) UUUCCGGCUCGCGUGGGUGUGU 806 hsa-miR-1323_st 0.326 19:54175222-554175294 (+) UCAAAACUGAGGGGCAUUUUCU 719 hsa-miR-3131_st 0.343 2:219923410-219923472 (−) UCGAGGACUGGUGGAAGGGCCUU 986 hsa-miR-1915-star_st 0.261 10:21785491-21785570 (−) ACCUUGCCUUGCUGCCCGGGCC 941 hsa-miR-323-5p_st 0.350 14:101492069-101492154 (+) AGGUGGUCCGUGGCGCGUUCGC 384 hsa-miR-194-star_st 0.294 CCAGUGGGGCUGCUGUUAUCUG 307 hsa-miR-658_st 0.350 22:38240279-38240378 (−) GGCGGAGGGAAGUAGGUCCGUUGGU 700 hsa-miR-4259_st 0.350 1:159869769-159869869 (−) CAGUUGGGUCUAGGGGUCAGGA 118 hsa-miR-1281_st 0.350 22:41488517-41488570 (+) UCGCCUCCUCCUCUCCC 900 hsa-miR-3130-3p_st 0.350 GCUGCACCGGAGACUGGGUAA 985 hsa-miR-302c-staR_st 0.350 4:113569519-413569586 (−) UUUAACAUGGGGGUACCUGCUG 344 hsa-miR-159-3p_st 0.306 11:72326107-72326174 (−) GGAGACGCGGCCCUGUUGGAGU 166 hsa-miR-1237_st 0.214 11:64136074-64 36175 (+) UCCUUCUGCUCCGUCCCCCAG 823 hsa-miR-1181_st 0.189 19:10514134-10514214 (−) CCGUCGCCGCCACCCGAGCCG 807 hsa-miR-3124_st 0.350 1:249120576-249120642 (+) UUCGCGGGCGAAGGCAAAGUC 976 hsa-miR-3150_st 0.350 8:96035142-96085221 (+) CUGGGGAGAUCCUCGAGGUUGG 1013 hsa-miR-449B-star_st 0.250 5:54466474-54466570 (−) CAGCCACAACUACCCUGCCACU 690 hsa-miR-574-5p_st 0.311 4:38869653-38869748 (+) UGAGUGUGUGUGUGUGAGUGUGU 584 hsa-miR-920_st 0.294 12:24365355-24365429 (+) GGGGAGCUGUGGAAGCAGUA 786 hsa-miR-939_st 0.280 8:145619364-145619445 (−) UGGGGAGCUGAGGCUCUGGGGGUG 797 hsa-miR-92a-1-star_st 0.280 AGGUUGGGAUCGGUUGCAAUGCU 123 hsa-miR-3195_st 0.350 20:60639858-60639941 (+) CGCGCCGGGCCCGGGUU 1070 hsa-miR-1207-3p_st 0.189 8:129061398429061484 (+) UCAGCUGGCCCUCAUUUC 834 hsa-miR-616_st 0.161 12:57912946-57913042 (−) AGUCAUUGGAGGGUUUGAGCAG 639 hsa-miR-1470_st 0.223 19:1556035945560419 (+) GCCCUCCGCCCGUGCACCCCG 921 hsa-miR-2277_st 0.250 5:92936402-92956494 (−) UGACAGCGCCCUGCCUGGCUC 961 hsa-miR-1225-3p_st 0.286 16:2140196-2140285 (−) UGAGCCCCUGUGCCGCCCCCAG 812 hsa-miR-769-3p_st 0.286 19:46522190-46522307 (+) CUGGGAUCUCCGGGGUCUUGGUU 729 hsa-miR-661_st 0.261 8:145019359-145019447 (−) UGCCUGGGUCUCUGGCCUGCGCGU 686 hsa-miR-4296_st 0.250 10:126721352-126121439 (−) AUGUGGGCUCAGGCUCA 1083 hsa-miR-1976_st 0.189 1:26881033-26881084 (+) CCUCCUGCCCUCCUUGCUGU 946 hsa-miR-668_st 0.214 14:101521595-101521660 (+) UGUCACUCGGCUCGGCCCACUAC 710 hsa-miR-4278_st 0.336 5:6827966-6828034 (−) CUAGGGGGUUUGCCCUUG 1148 hsa-miR-3151_st 0.223 8:104166842-104166917 (+) GGUGGGGCAAUGGGAUCAGGU 1014 hsa-miR-4327_st 0.283 21:31747612-31747696 (−) GGCUUGCAUGGGGGACUGG 1127 hsa-miR-3180-5p_st 0.221 CUUCCAGACGCUCCGCCCCACGUCG 1048 hsa-miR-623_st 0.325 13:100008385-100008482 (+) AUCCCUUGCAGGGGCUGUUGGGU 648 hsa-miR-1909-star_st 0.159 19:1816158-1816237 (−) UGAGUGCCGGUGCCUGCCCUG 932 hsa-miR-3187_st 0.294 19:813584-813653 (+) UUGGCCAUGGGGCUGCGCGG 1060 hsa-miR-4253_st 0.302 1:23189652-23189719 (−) AGGGCAUGUCCAGGGGGU 1120 hsa-miR-639_st 0.275 19:14640355-14640452 (+) AUCGCUGCGGUUGCGAGCGCUGU 670 hsa-miR-4322_st 0.261 19:10341089-10341161 (+) CUGUGGGCUCAGCGCGUGGGG 1111 hsa-miR-4266_st 0.214 2:109930027-109930081 (−) CUAGGAGGCCUUGGCC 1130 hsa-miR-760_st 0.189 1:94312388-94312467 (+) CGGCUCUGGGUCUGUGGGGA 782 hsa-miR-197_st 0.189 1:110141515-110141589 (+) UUCACCACCUUCUCCACCCAGC 30 hsa-miR-637_st 0.232 19:3961412-3961510 (−) ACUGGGGGCUUUCGGGCUCUGCGU 668 hsa-miR-1231_st 0.350 1:201777739-201777830 (+) GUGUCUGGGCGGACAGCUGC 819 hsa-miR-886-5p_st 0.286 5:135416177-135416297 (−) CGGGUCGGAGUUAGCUCAAGCGG 746 hsa-miR-3180-3p_st 0.250 UGGGGCGGAGCUUCCGGAGGCC 1049 hsa-miR-346_st 0.085 10:88024451-88024545 (−) UGUCUGCCCGCAUGCCUGCCUCU 16 hsa-miR-935_st 0.221 19:54485561-54485651 (+) CCAGUUACCGCUUCCGCUACCGC 793 hsa-let-7b-star_st 0.161 22:46509566-46509648 (+) CUAUACAACCUACUGCCUUCCC 69 hsa-miR-193b-star_st 0.161 16:14397824-14397906 (+) CGGGGUUUUGAGGGCGAGAUGA 465 hsa-miR-885-3p_st 0.250 3:10436173-10436246 (−) AGGCAGCGGGGUGUAGUGGAUA 773 hsa-miR-4283_st 0.109 UGGGGCUCAGCGAGUUU 1152 hsa-miR-371-3p_st 0.283 19:54290929-54290995 (+) AAGUGCCGCCAUCUUUUGAGUGU 355 hsa-miR-548q_st 0.159 10:12767253-12767352 (−) GCUGGUGCAAAAGUAAUGGCGG 959 hsa-miR-596_st 0.204 8:1765397-1765473 (+) AAGCCUGCCCGGCUCCUCGGG 616 hsa-miR-636_st 0.246 17:74732532-74732630 (−) UGUGCUUGCUCGUCCCGCCCGCA 667 hsa-miR-943_st 0.221 4:1988111-1988204 (−) CUGACUGUUGCCGUCCUCCAG 801 hsa-miR-193a-5p_st 0.189 17:29887015-29887102 (+) UGGGUCUUUGCGGGCGAGAUGA 296 hsa-miR-486-3p_st 0.214 8:41517959-41718026 (−) CGGGGCAGCUCAGUACAGGAU 443 hsa-miR-4321_st 0.223 19:2250638-2250717 (+) UUAGCGGUGGACCGCCCUGCG 1112 hsa-miR-557_st 0.250 1:168344762-168344859 (+) GUUUGCACGGGUGGGCCUUGUCU 567 hsa-miR-4279_st 0.198 5:31936208-31936265 (−) CUCUCCUCCCGGCUUC 1147 hsa-miR-138-1-star_st 0.232 GCUACUUCACAACACCAGGGCC 24 hsa-miR-373-star_st 0.232 19:54291959-54292027 (+) ACUCAAAAUGGGGGCGCUUUCC 357 hsa-miR-885-5p_st 0.232 3:10436173-10436246 (−) UCCAUUACACUACCCUGCCUCU 772 hsa-miR-185-star_st 0.280 22:20020662-20020743 (+) AGGGGCUGGCUUUCCUCUGGUC 58 hsa-miR-3123_st 0.021 1:241295572-241295646 (+) CAGAGAAUUGUUUAAUC 59 hsa-miR-1910_st 0.021 16:85775227-85775306 (−) CCAGUCCUGUGCCUGCCGCCU 8 hsa-miR-139-5p_st 0.350 11:72326107-72326174 (−) UCUACAGUGCACGUGUCUCCAG 25 hsa-miR-486-5p_st 0.173 8:41517959-41518026 (−) UCCUGUACUGAGCUGCCCCGAG 61 hsa-miR-519a_st 0.122 AAAGUGCAUCCUUUUAGAGUGU 62 hsa-miR-7_st 0.272 UGGAAGACUAGUGAUUUUGUUGU 2

TABLE 5C FNA Set 2 Model Logistic Weight Predictor Coefficient (Intercept) 1.759924 Diff(miR-141,miR-7) −0.27689 Diff(miR-375,miR-7) −0.16405 Diff(miR-138-1#,miR-155) −0.11432 Diff(miR-138-1#,miR-7) −0.10224 Diff(miR-31,miR-7) −0.02884 Diff(miR-141,miR-155) −0.01636 Diff(miR-155,miR-31) 0.0037 Diff(miR-155,miR-375) 7.54E−16

Example 3 qRT-PCR Experiments and Data Analysis Methods for the Development of a miRNA Classifier

Samples and qRT-PCR experiments: Two sets of FNA specimens were used for the development of miRNA classifier. The first set (Set 1) contained a total of 14 samples corresponding to 8 benign and 6 malignant specimens, respectively, as described in Table 3A. qRT-PCR reactions were performed using TaqMan MicroRNA Assays (Applied Biosystems; Foster City, Calif., USA) according to the manufacturer's instructions. Reactions were done in duplicates and included 5 ng of total nucleic acids (TNA) per reaction. The reactions were incubated in the 7900HT Fast Real-Time PCR System (Applied Biosystems). The miRNAs tested for Set 1 were: miRs-138-1#, -139-5, -146b-3p, -146b-5p, -21, -222, -320a, -34a, -375, -423-5p, -625#, -7, -126, -143, -144, -193a-3p, -193a-5p, -195, -204, -222#, -320a, -451, -486-3p, and miR-486-5p. These miRNAs were selected based on array analysis of the FFPE samples, as well as additional information obtained from previous work on thyroid tissues using fresh frozen biopsies.

TABLE 6 (former Table *5): qRT-PCR data obtained using the first set (Set1) as a training set for the development of the miRNA classifier. miRNAs NTC AVG_Benign SD_Benign AVG_Malignant SD_Malignant miR-625# 31.58 29.07 1.09 29.27 0.19 miR-423-5p 40.00 29.47 1.47 29.20 0.47 miR-320a 40.00 24.73 t.66 25.26 0.40 miR-126 40.00 24.72 2.06 25.29 0.73 miR-138-1# 39.25 32.94 1.02 32.45 1.02 miR-139-5p 3851 30.51 1.86 29.77 0.45 miR-143 40.00 36.31 1.04 35.35 0.74 miR-144 37.51 28.61 2.84 30.19 1.12 miR-146b- 40.00 35.62 0.90 29.82 2.86 3p miR-146b- 40.00 28.48 1.85 22.94 3.10 5p miR-193a-3p 40.00 35.41 1.05 34.83 0.62 miR-193a-5p 40.00 30.55 1.17 29.67 0.88 miR-195 40.00 27.03 2.04 27.68 0.51 miR-204 40.00 31.59 1.90 31.50 1.53 miR-21 40.00 27.20 1.86 26.51 1.20 miR-222# 40.00 35.82 1.58 32.49 0.73 miR-222 40.00 25.56 1.41 22.37 0.93 miR-34a 40.00 36.79 1.03 35.13 0.47 rniR-375 40.00 35.29 2.33 27.80 1.66 miR-451 40.00 23.17 2.61 24.09 0.98 miR-486-3p 39.46 26.61 2.14 27.26 0.86 miR-486-5p 40.00 20.50 2.28 21.65 1.35 miR-7 40.00 29.74 1.67 31.12 1.84 NTC, no template control. The miRNAs indicated in italics were used as putative normalizers.

The second set of FNAs (Set 2) contained a total of 21 samples corresponding to a benign group of 5 samples in which no mutation had been identified, a benign group of 5 samples in which mutations had been identified, and a group of 5 malignant samples in which no mutation had been identified and a group of 5 malignant samples in which mutations had been identified, with the exclusion of BRAF mutation. An additional malignant sample was used that contained a BRAF V600E mutation (Table 3B). The miRNAs tested in the second FNA set were miRs-138-1#, -139-5, -146b-3p, -146b-5p, -21, -222, -320a, -34a, -375, -423-5p, -625#, -7, -141, -145, -155, -183, -197, -224, -31, and miR-425-5p. These miRNAs were selected based on array analysis of the FFPE samples excluding BRAF-positive FFPE tumors, as well as additional information obtained from previous work on thyroid tissues using fresh frozen biopsies and data recently published in the literature (Kitano et al., 2011; Nikiforova. et al., 2009).

TABLE 7 (former Table *6): qRT-PCR data obtained using the first set (Set2) as a training set for the development of the miRNA classifier. miRNAs NTC AVG_Benign SD_Benign AVG_Malignant SD_Malignant miR-625# 31.38 28.66 1.56 28.72 1.10 miR-423-5p 40.00 27.36 2.76 27.73 1.83 miR-320 40.00 23.33 2.90 23.91 2.00 miR-138-1# 33.98 33.40 2.64 32.05 2.31 miR-139-5p 40.00 31.24 3.38 30.75 3.36 miR-141 40.00 30.85 4.09 28.42 2.79 miR-145 35.26 30.20 3.05 30.00 2.19 miR-146b-3p 40.00 34.92 2.00 32.92 3.57 miR-146b-5p 40.00 28.32 2.87 26.83 3.56 miR-155 40.00 30.03 3.44 30.71 2.70 miR-183 40.00 29.50 3.12 30.00 2.35 miR-197 40.00 28.52 2.56 28.45 2.01 miR-21 40.00 25.12 2.23 25.56 2.30 miR-222 40.00 26.19 2.82 25.27 2.70 miR-224 40.00 33.90 2.13 33.88 2.51 miR-31 40.00 31.05 3.56 29.22 2.91 rniR-34a 35.47 29.03 2.02 27.61 2.16 miR-375 40.00 33.81 4.02 30.82 3.87 miR-425-5p 40.00 26.10 3.29 26.46 2.41 miR-7 40.00 27.56 2.69 29.73 4.32 NTC, no template control. The miRNAs indicated in italics were used as putative normalizers.

DiffPair Normalization

DiffPairs, normalized biomarkers whose values are defined as the difference in expression values (Ct values for qRT-PCR data) between two distinct miRNAs, were used as the normalization method for qRT-PCR data. DiffPair normalization is similar to normalization using a specified normalizer reference gene with the modification that different DiffPairs use different reference genes. Because the DiffPair itself is regarded as a biomarker, DiffPair normalization does not require the assumption that either miRNA composing a given DiffPair is stably expressed across all samples, making DiffPair normalization appropriate in some conditions for which use of fixed normalizer genes can be problematic.

Logistic Regression for Construction of Classifier

L1-penalized regression (Tibshirani 1996, Goeman 2010), as implemented by the R package penalized, was used to fit logistic model classifier to DiffPaired FNA data sets. The use of an L1-penalty term integrates feature selection, whereby only those DiffPairs who combine to produce the best fitting model without requiring large model weights are allowed to be used as model predictors, directly into the model-training process in order to prevent statistical over-fitting. The L1-penalty used for model-fitting was always fixed at a constant value based on prior assessment of reasonable values for logistic regression models using DiffPaired qRT-PCR data. Performance of this logistic regression modeling methodology was assessed using 5-fold cross-validation (Hastie 2009).

Example 4 Sample Information.

We tested an independent set of 65 thyroid FFPE specimens (Set 2) corresponding to 29 benign and 36 malignant neoplasms. The benign samples corresponded to 9 hyperplastic nodules (HN), 8 follicular adenomas (FA), 3 oncocytic follicular adenoma (OFA), 4 multi nodular goiters (MNG), and 5 Hashimoto's thyroiditis (HASH). The malignant samples corresponded to 19 papillary carcinomas (PTC), 8 follicular variant of papillary carcinomas (FVPTC), and 9 follicular carcinomas (FTC). Information regarding these samples is provided in Table X. Total RNA was isolated from each sample, using the RecoverAll RNA Isolation Kit (Ambion Austin Tex., USA). Total RNA was quantified using a NanoDrop® ND-1000 spectrophotometer (NanoDrop Technologic Inc, Wilmington, Del., USA). The samples were tested for mutations and translocations, using Asuragen miRInform® Thyroid Marker Panel. The mutational results of the assay are indicated in Table X.

TABLE X Patient information and histopathological data for the second set (Set2) of thyroid FFPE samples. AJCC/ AJCC/ UICC Sample Pathology- Excision UICC Stage miRInform ® ID (Abbr) Histopathology Age Sex Ethnicity Year Stage Group Thyroid AF117 PTC Papillary 38 F AA 1995 T2N1MX I BRAF V600E carcinoma AF118 FTC Follicular 47 F C 1995 T2NIXMX II PAX8/PPARg carcinoma AF119 MNG Goiter, 44 F C 1996 T1bN1MX III Neg multinodular AF120 FTC Follicular 46 F C 1996 T3NXMX III Neg carcinoma AF121 FA Follicular adenoma 47 F C 1996 T2NXMX II Neg AF122 Hash Follicular Adenoma 52 F C 2006 T2NXM0 II Neg AF123 FA Follicular Adenoma 41 F C 2007 T3NXM0 I Neg AF124 NH Nodular 54 M C 2009 N/A N/A Neg Hyperplasia AF125 PTC Papillary 24 M C 2007 T3N1MX I BRAF V600E Carcinoma AF126 PTC Papillary 45 F C 2008 T3NXM0 III Neg Carcinoma AF127 NH Nodular 88 F C 2009 N/A N/A Neg Hyperplasia AF128 FvPTC Papillary 38 F C 2009 T2NXMX I Neg Carcinoma, Follicular Variant AF129 FTC Follicular 52 F C 2010 T2NXM0 II Neg carcinoma AF130 PTC Papillary 49 F C 2009 T3N0M0 III Neg carcinoma AF131 PTC Papillary 40 F C 2009 T2N0M0 I Neg carcinoma AF132 FTC Follicular 79 F C 2009 T1N1M0 III Neg Carcinoma AF133 FA Hyperplasia 70 M C 2009 N/A N/A Neg AF134 PTC Papillary 53 F C 2009 T2N0M0 II BRAF V600E carcinoma AF135 MNG Goiter, 73 M C 2009 N/A N/A Neg multinodular AF136 PTC Papillary 77 N AP 2011 T3NXM0 III Neg carcinoma AF137 PTC Papillary 24 M AP 2011 T3NXM0 I BRAF V600E carcinoma AF138 PTC Papillary 19 F AP 2011 T1bNXM0 I BRAF V600E carcinoma AF139 PTC Papillary 67 F AP 2011 T3NXM0 III BRAF V600E carcinoma AF140 NH Nodular 68 F C 2008 T3NXM0 III Neg Hyperplasia AF141 PTC Papillary 58 F C 1994 T3NXMX III BRAF V600E carcinoma AF142 FA Follicular adenoma 36 M C 1994 T2NXMX I Neg AF143 oFA Hurthle cell 52 M C 1994 T3NXMX III Neg adenoma AF144 FvPTC Papillary 29 F C 1994 T3NXMX I BRAF V600E carcinoma, follicular variant AF145 FA Follicular adenoma 38 F C 1994 N/A N/A Neg AF146 FTC Follicular 67 M C 1993 T3NXMX III HRAS Q61R carcinoma AF147 PTC Papillary 54 F C 2008 T2NXM0 II Neg Carcinoma AF148 NH nodular 66 M C 2004 N/A N/A Neg hyperplasia AF149 NH Nodular 45 M C 2004 N/A N/A Neg Hyperplasia AF150 NH Nodular 46 F C 2004 N/A N/A Neg Hyperplasia AF151 FTC Follicular 61 F C 1994 TXNXMX Neg carcinoma AF152 FA Follicular adenoma 65 F C 1995 N/A N/A Neg AF153 FTC Follicular 46 F C 1997 T2NXMX PAX/PPARG carcinoma AF154 Hash Hashimoto's 48 F C 1995 N/A N/A Neg thyroiditis AF156 NH Nodular 29 F C 2004 T1N0M0 I Neg Hyperplasia AF157 FA Follicular Adenoma 47 M C 2006 T2NXMX II Neg AF158 Hash Hashimoto's 81 M C 1995 T2N0MX II Neg thyroiditis AF159 Hash Hashimoto's 45 F AP 1995 T1aN0MX I Neg thyroiditis AF160 PTC Papillary 37 F C 1996 T2NXMX I BRAF V600E carcinoma AF161 FA Follicular adenoma 31 F C 1996 T2NXMX I Neg AF162 NH Nodular N/A N/A N/A N/A N/A N/A Neg Hyperplasia AF163 FTC Follicular 75 F BAA 1994 T3NXMX III NRAS Q61K carcinoma AF164 FA Follicalar adenoma 44 M C 1994 N/A N/A Neg AF165 FTC Follicular 60 F C 1995 T4aNXMX IVA Neg carcinoma AF166 oFA Hurthle cell 42 F C 1995 N/A N/A Neg adenoma AF167 MNG Goiter, 46 F C 1995 N/A N/A Neg multinodular AF168 MNG Goiter, 36 F C 1995 T2NXMX I Neg multinodular AF169 Hash Hashimoto's 36 F C 1995 N/A N/A Neg thyroiditis AF170 FvPTC Papillary 35 M C 1997 T2NXMX Neg carcinoma, follicular variant AF171 FvPTC Papillary F C 60 1997 T4NXMX HRAS Q61L carcinoma, follicular variant AF172 PTC Papillary 52 F C 2005 T3N1aM0 III Neg Carcinoma AF173 FvPTC Papillary 52 F C 2002 T2NXM0 II Neg Carcinoma, Follicular Variant AF174 PTC Papillary N/A N/A N/A N/A N/A N/A BRAF V600E Carcinoma AF175 PTC Papillary 24 M C 1997 T3N1MX I Neg carcinoma AF176 FvPTC Papillary 40 F C 1996 T2NXMX I BRAF V600E carcinoma, follicular variant AF177 FvPTC Papillary 53 F C 1997 N/A N/A Neg carcinoma, follicular variant AF178 FvPTC Papillary 63 M C 2001 N/A N/A BRAF V600E Carcinoma, Follicular Variant AF179 PTC Papillary 52 F C 2006 T1NXMX I Neg Carcinoma AF180 PTC Papillary 46 F C 2006 T1NXMX I Neg Adenocarcinoma AF181 PTC Papillary 62 F C 2006 T3NXM0 III BRAE V600E Carcinoma AF183 Hash Hashimoto's 73 F C 1996 T1aN0MX I neg thyroiditis Anaplastic cancer (ATC); Follicular Adenoma (FA); oncocytic FA (OFA); Follicular carcinoma (FTC); Papillary carcinoma (PTC); Follicular variant of PTC (FvPTC), Hashimoto's thyroiditis (HASH); multinodular goiter (MNG); hyperplastic nodules (HN); Age at Excision (Age); Male (M); Female (F); African-American (AA); Black/African-American (BAA); Caucasian (C); Asian/Pacific (AP) miRNA Profiling Analysis.

A total of 65 FFPE samples from 29 benign and 36 malignant neoplasms were profiled using the Affymetrix GeneChip® miRNA Arrays V2 in Asuragen Services and then analyzed by Asuragen's bioinformatics group (Asuragen). The Affymetrix miRNA arrays contain probes for more than 1,000 human miRNAs from Sanger miRbase V11.0 (on the World Wide Web at asuragen.com/Services/services). A total of 200 ng of total RNA corresponding to each of the 65 thyroid FFPE was labeled as described in the materials and methods. The thyroid samples were separated in 2 different groups for analysis, corresponding to Benign (hyperplastic nodules (HN; n=9), follicular adenoma (FA; n=8), oncocytic follicular adenoma (OFA; n=3), multi nodular goiter (MNG; n-4), and Hashimoto's thyroiditis (HASH; n==5)) and Malignant (papillary carcinomas (PTC; n=19), follicular variant of papillary carcinomas (FvPTC; n=8), and follicular carcinomas (FTC; n=9). The average levels of expression of each miRNA in each subset of the different groups of samples are shown in Table Y, which is provided at the end of the description.

miRNAs can Distinguish Benign and Malignant Thyroid Neoplasms

A total of 410 human miRNAs were significantly differentially expressed between the Benign and the Malignant groups of samples (p<0.05). Among these, 115 miRNAs were over-expressed (Log 2 diff (Malignant vs Benign)≥1) by at least 2-fold in the Malignant group compared to the Benign group of samples, with a p-value≤0.05. Of these, hsa-miR-146b-5p was over-expressed by more than 30-fold in Malignant vs Benign, and hsa-miR-146b-3p and miR-375 were over-expressed between 9- and 15-fold in the Malignant group of lesions compared to the Benign group of specimens (Table Y). In addition, hsa-miR-221, -221*, -222, -31*, -181a-2*, -551b, -424, -31, -21, and -429 were overexpresssed between 5- and 9-fold in Malignant lesions compared to Benign specimens (Table Y). Only one miRNA, miRNA-7, was down-regulated by at least 2-fold in Malignant compared to Benign lesions (Table Y).

As follicular thyroid cancers are more difficult to diagnose than papillary thyroid cancers, we also compared the miRNA expression profiles of the Follicular thyroid cancer (FTC) group of samples with those of the Benign group of samples. A total of 195 human miRNAs were significantly differentially expressed between the FTC and the Benign groups of samples (p<0.05). Among these, 66 miRNAs were over-expressed (Log 2 diff (FTC vs Benign)≥1) by at least 2-fold in the FTC group compared to the Benign group of samples, with a p-value≤0.05. Of these, two miRNAs, hsa-miR-96 and -182, were over-expressed by more than 5-fold. In FTC vs Benign (Table Y). There was no miRNA down-regulated by at least 2-fold in FTC compared to Benign lesions (Table Y).

A particularly challenging diagnostic issue is to distinguish Follicular carcinoma from Follicular adenoma due to overlapping cytological features between the two entities. We therefore also compared the expression profiles of the Follicular thyroid cancer (FTC) group of samples with those of Follicular adenoma (FA). A total of 101 human miRNAs were significantly differentially expressed between the FTC and the FA groups of samples (p<0.05). Among these, 22 miRNAs were over-expressed (Log 2 diff (FTC vs Benign)≥1) by at least 2-fold in the FTC group compared to the FA. group of samples, with a p-value≤0.05. Of these, two miRNAs, hsa-miR-146b-5p and -181a-2*, were over-expressed by more than 3-fold in FTC vs FA, and 20 miRNAs were over-expressed between 2- and 3-fold in FTC compared to FA (Table Y). There was no miRNA down-regulated by at least 2-fold in FTC compared to FA lesions (Table Y).

Hashimoto's lesions represent also a challenging diagnostic issue. We compared the miRNA expression profiles of the Hashimoto's group of samples (Hash) with those of other benign conditions. A total of 108 human miRNAs were significantly differentially expressed between the Hash and the Benign groups of samples (p<0.05). Among these, 8 miRNAs were over-expressed (Log 2 diff (Hash vs Benign)≥1) by at least 2-fold in the lash group compared to the other Benign group of samples, with a p-value≤0.05. Of these, one miRNA, hsa-miR-142-5p was over-expressed by more than 5-fold in Hash vs Benign. In addition, seven miRNAs, hsa-miR-150, -146b-5p, -155, -146a, -223, -199b-5p, and -31 were over-expressed between 2- and 5-fold in Hash compared to Benign (Table Y). A total of 12 miRNAs were under-expressed in Hash vs Benign by more than 2-fold (Log 2 diff (Hash vs Benign)≤1). Among these, only one miRNA, hsa-miR-7, was down-regulated by more than 5-fold in Hash vs Benign and 11 other miRNas were under-expressed by at least 2-fold in Hash samples compared to the Benign specimens (Table Y). The same comparison was made between Hash samples and the Malignant group of Thyroid specimens. A total of 350 human, miRNAs were significantly differentially expressed between the Hash and the Malignant groups of samples (p<0.05). Among these, 27 miRNAs were over-expressed (Log 2 diff (Hash vs Malignant)≥1) by at least 2-fold in the Hash group compared to the Malignant group of samples, with a p-value≤0.05 (Table Y). A total of 126 miRNAs were under-expressed in Hash vs Malignant by more than 2-fold (Log 2 diff (Hash vs Malignant)≤1). Among these, three miRNAs, hsa-miR-146b-3p, -200b, and -181a-2*, were down-regulated by at least 10-fold in Hash samples compared to the Malignant specimens (Table Y). A total of 21 miRNAs were down-regulated between. 5- and 10-fold in the Hash versus the Malignant groups of specimens, and 102 miRNAs were under-regulated between 2- and 5-fold in the Hash compared to the Malignant groups of samples (Table Y).

Other Set of FFPE Samples (Set3)

A set of 41 FFPE samples containing 21 malignant and 20 benign thyroid neoplasms including 6 Hashimoto's specimens, was also analyzed to further to build a classifier that. can identify Hashimoto's disease among other benign and malignant thyroid conditions. Information regarding the samples is provided in Table Z1. Total nucleic acids (TNA) were isolated from each sample, using the RecoverAll RNA Isolation Kit (Ambion; Austin, Tex., USA), Total RNA was quantified using a NanoDrop® ND-1000 spectrophotometer (NanoDrop Technologie Inc, Wilmington, Del., USA). The samples were tested for mutations and translocations, using Asuragen miRInform® Thyroid Marker Panel. The mutational results of the assay are indicated in Table Z1. These samples were analyzed by RT-qPCR, as described below.

TABLE Z1 Histopathological information and mutation status for the third set of FFPE samples (Set3) Sample ID Histopathology miRinform ® Thyroid AF184 TcPTC Neg AF185 PTC BRAF V600E AF186 PTC BRAF V600E AF187 TcPTC BRAF V600E AF188 Hashimoto's Neg AF189 Hashimoto's Neg AF190 Hashimoto's BRAF V600E AF191 Hashimoto's Neg AF192 FA Neg AF193 FA Neg AF194 FA Neg AF195 FA Neg AF196 FA Neg AF197 PTC Neg AF198 PTC Neg AF199 PTC Neg AF200 FA BRAF V600E AF201 FA Neg AF202 FvPTC BRAF V600E AF203 FvPTC Neg AF204 PTC Neg AF205 FvPTC Neg AF206 PTC HRAS Q61R AF207 PTC Neg AF208 PTC NRAS Q61R AF209 PTC Neg AF210 PTC Neg AF211 PTC BRAF V600E AF212 PTC Neg AF213 MNG BRAF V600E AF214 MNG Neg AF215 MNG BRAF V600E AF216 MNG Neg AF217 MNG Neg AF218 MNG Neg AF219 MNG Neg AF220 Hashimoto's Neg AF221 Hashimoto's Neg AF222 TcPTC Neg AF223 PTC Neg AF224 PTC Neg Abbreviations: Papillary carcinoma (PTC); Follicular variant of PTC (FvPTC), Tall cell variant of PTC (TcPTC); Hashimoto's thyroiditis (HASH); multinodular goiter (MNG); Follicular adenoma (FA) Constrained Logistic Regression Method for Constructing miRNA-Based Classifiers.

A variety of different models can be employed to evaluate expression. levels and/or other comparative values based on expression levels of miRNAs (or their precursors or targets). In particular, a logistic regression model (see the Wikipedia entry on the World Wide Web at en.wikipedia.org/wiki/Logistic_regression, which is hereby incorporated by reference) distinguishing between two diagnostic groups consists of a set of predictor variables, X_(i) for i between 1 and n together with a set of weight coefficients w_(i) for i between 0 and n, from which the probability that a sample with predictor values X_(i)=x_(i) is in the first diagnostic group can be computed as

$P_{malignant} = \frac{1}{1 + {\exp \left( {{- w_{0}} - {\sum\limits_{i = 1}^{n}{w_{i}x_{i}}}} \right)}}$

Other examples of models include but are no limited to decision trees, linear or quadratic discriminant analysis, neural networks, support vector machines, and k-nearest neighbor classifiers. A person of ordinary skill in the art could use these different modeling procedures to evaluate expression level data and comparative data involving expression. levels of one or miRNAs (or their precursors or their targets).

Because of the difficulties involved in precisely controlling the amount of intact RNA input for qRT-PCR assays, it is generally desirable to construct models which take as inputs comparative differences in expression between two or more biomarkers instead of the raw cycle threshold (Ct) values measured for individual miRNA biomarkers. One method for accomplishing this is to consider a DiffPair consisting of two biomarkers A. and B associated with the value computed as the difference in Ct value between marker A and marker B (i.e, if x_(A) is the Ct value of marker A and x_(B) is the Ct value of marker B, then x_(A)-x_(B) is the value of the DiffPair Diff(A,B)).

In fitting logistic regression models, an alternative method for adjusting for potential differential intact RNA input levels to the DiffPair method described above is to constrain the sum of the weight coefficients w_(i) for i>0 to be equal to zero:

${\sum\limits_{i = 1}^{n}w_{i}} = 0$

The result of fitting such as a constrained logistic regression model is that, as in the case with DiffPair values, the model output scores are insensitive to any changes to biomarker Ct values that change the measured Ct values of all predictors upwards or downwards by the same amount, so that only relative expression levels between multiple biomarkers are used by the resulting model to predict the probability of malignancy. Note that in the case of exactly two biomarkers, this constrained logistic regression model becomes a logistic regression model built on a single DiffPair. More generally, models built with this type of constraint can be equivalently described in terms of an unconstrained logistic regression model built using a set of DiffPairs for more than two biomarkers as well (although this may increase the complexity of modeling process).

The classifier algorithms presented below were constructed using only subsets of the singleplex-measured miRNA biomarkers. For each model, the strategy for selection of the miRNA subset used by that model was to choose biomarkers using an unconstrained L2-penalized stepwise logistic regression strategy (L2 penalty parameter set in all cases to λ₂=2.5). Once the subset of biomarkers to be used as predictors for a given model had been identified, the final model was constructed by fitting using the constrained logistic regression described above (again using an L2-penalty λ2=2.5) to the selected predictors. Classifier performance was estimated using leave-one-out-cross-validation evaluating the entire modeling process, including feature selection.

Results for Constrained Logistic Regression Classifier to Identify Hashimoto's Disease

The intercept (w₀) and weight coefficients (w_(i) for i>0) for the constrained logistic regression classifier for Hashimoto's disease are indicated in

.

TABLE DX Predictor Coefficient (Intercept) −8.95 miR-155-5p −0.93 miR-31-5p −0.26 miR-151-3p 0.35 miR-224-5p 0.84

As estimated by leave-one-out-cross-validation (LOOCV) for the modeling strategy described above, the observed accuracy was 93% (95% CI: 80%-98%), sensitivity 67% (95% CI: 22%-96%), specificity 97% (95% CI: 85-100%), with an estimated AUC of 0.98. The confidence interval for sensitivity is very wide because the data set used to train this classifier contained only 6 Hashimoto's samples. The LOOCV classification scores produced by this model are shown in FIG. 6. This classifier is presented as a preliminary example of the type of classifier we intend to develop for the task of separating Hashimoto's disease samples from other thyroid samples. MiR-155, which showed elevated expression in Hashimoto's samples as compared with samples of other diagnostic groupings, is assigned the most negative coefficient in this model. The most positive model coefficient is assigned to miR-224, which exhibits reduced expression in Hashimoto's samples.

FNA Samples

A total of 62 FNA specimens were analyzed. These samples were classified as benign or malignant, according to their cytology and/or histology report, as described in Table W1. Molecular testing was performed using Asuragen miRInform Thyroid mutation panel assay (Table W1). FNA specimens, corresponding to an entire extra-pass, were collected according to the institutional IRB-approved protocol as a part of standard clinical care, and all samples were de-identified. Upon collection, FNAs were placed in 1 mL of Asuragen's RNARetain™ nucleic acid stabilization solution and shipped to Asuragen at room temperature for molecular testing. Total RNA was extracted using a modified mirVana PARIS™ procedure and proprietary Asuragen protocols optimized for recovery of nucleic acids from RNARetain. Concentration and purity of RNA were measured using the NanoDrop ND-1000 Spectrophotometer (NanoDrop Technologies Inc, Wilmington, Del., USA).

TABLE W1 Classification of the FNAs used in the third set (Set3) of samples. The samples were classified in two or three categories, according to their cytological and histological reports. For cytology, the Bethesda classification was used, and the samples were classified as Benign, Malignant, Indeterminate, or Non-diagnostic, according to their cytology reports. The samples were classified according to their histology reports as Benign or Malignant, and as Benign* when the cytology was benign and no surgery had been performed after 6 months to 2 years of follow-up. The mutational status of each sample is indicated, as determined by the miRInform ® ThyroidPanel Assay. Papillary thyroid cancer (PTC); Follicular variant of papillary thyroid cancer (FvPTC). Neg in the mutation column indicates that no mutation or translocation was found in the sample. Sample ID Cytology categories Histology categories Mutation status FNA-T1 Malignant Malignant Neg FNA-T2 Malignant Malignant Neg FNA-T3 Malignant Malignant Neg FNA-T4 Malignant Malignant Neg FNA-T5 Malignant Malignant Neg FNA-T6 Indeterminate Malignant Neg FNA-T7 Malignant Malignant Neg FNA-T8 Malignant Malignant Neg FNA-T9 Indeterminate Malignant Neg FNA-T10 Malignant Malignant BRAF V600E FNA-T11 Non diagnostic Malignant BRAF V600E FNA-T12 Malignant Malignant BRAF V600E FNA-T13 Malignant Malignant BRAF V600E FNA-T14 Malignant Malignant BRAF V600E FNA-T15 Benign Malignant NRAS Q61R FNA-T16 Malignant Malignant Neg FNA-T17 Malignant Malignant BRAF V600E FNA-T18 Malignant Malignant BRAF V600E FNA-T19 Malignant Malignant BRAF V600E FNA-T20 Benign Benign* Neg FNA-T21 Malignant Malignant BRAF V600E FNA-T22 Malignant Malignant BRAF V600E FNA-T23 Malignant Malignant BRAF V600E FNA-T24 Benign Benign* Neg FNA-T25 Benign Benign* Neg FNA-T26 Benign Benign* Neg FNA-T27 Benign Benign* Neg FNA-T28 Indeterminate Benign Neg FNA-T29 Benign Benign* Neg FNA-T30 Benign Benign* Neg FNA-T31 Benign Benign* Neg FNA-T32 Indeterminate Benign Neg FNA-T33 Benign Benign Neg FNA-T34 Benign Benign* Neg FNA-T35 Benign Benign* Neg FNA-T36 Benign Benign* Neg FNA-T37 Benign Benign* Neg FNA-T38 Benign Benign* Neg FNA-T39 Benign Benign* Neg FNA-T40 Benign Benign* Neg FNA-T41 Benign Benign* Neg FNA-T42 Malignant Malignant BRAF V600E FNA-T43 Malignant Malignant BRAF V600E FNA-T44 Malignant Malignant BRAF V600E FNA-T45 Malignant Malignant BRAF V600E FNA-T46 Malignant Malignant BRAF V600E FNA-T47 Malignant Malignant RET/PTC1 FNA-T48 Malignant Malignant BRAF V600E FNA-T49 Malignant Malignant BRAF V600E FNA-T50 Malignant Malignant BRAF V600E FNA-T51 Malignant Malignant BRAF V600E FNA-T52 Malignant Malignant BRAF V600E FNA-T53 Benign Benign* Neg FNA-T54 Benign Benign* Neg FNA-T55 Benign Benign* Neg FNA-T56 Benign Benign* Neg FNA-T57 Indeterminate Malignant HRAS Q61R FNA-T58 Indeterminate Malignant NRAS Q61R FNA-T59 Malignant Malignant BRAF V600E FNA-T60 Benign Benign* Neg FNA-T61 Benign Benign* Neg FNA-T62 Benign Benign* Neg Real-Time Assays and miRNA Classifiers

Real-time RT-qPCR reactions were performed for the 26 candidate miRNAs described in Table O (hsa-miR-375, -146b-3p, -146b-5p, -221, -222, -551b, -204, -7, -141, -31, -181a*-2, -15a, -221*, -21, -424, -34a, -197, -19b, -138-1*, -139-5p, -155, -151-3p, -29b, -96, -328, and 29b-1*). RT-qPCR reactions were performed in duplicates, using Exiqon miRCURY LNA™ Universal RT microRNA PCR Assays (Exiqon A/S, Denmark), using an optimizedversion of the manufacturer's protocol. Reactions included either 20 ng (FFPE samples) or 50 ng (FNAs) of total nucleic acids per reaction and were incubated in the 7900 Fast System SDS 2.3 software.

TABLE O  List of miRNAs miR Name Alternate Name Sequence miR-375 miR-375 uuuguucguritggcucgcguga miR-7 miR-7-5p uggaagacuagugauuuuguugu miR-15a miR-15a-5p uagcagcacauaaugguuugug miR-19b miR-19b-3p ugugcaaauccaugcaaaacuga miR-21 miR-21-5p uagcuuaucagacugauguuga miR-29b miR-29b-3p uagcaccauuugaaaucaguguu miR-29b-1* miR-29b-1-5p gcugguuucauauggugguuuaga miR-31 miR-31-5p aggcaagaugcuggcauagcu miR-34a miR-34a-5p uggcagugucuuagcugguugu miR-96 miR-96-5p uuuggcacuagcacauuuuugcu miR-138-1* miR-138-1-3p gcuacuucacaacaccagggcc miR-139-5p miR-139-5p ucuacagugcacgugucuCcag miR-141 miR-141-3p uaacacugucugguaaagaugg miR-146b-3p miR446b-3p ugcccuguggacucaguucugg miR-146b-5p miR-1466-5p ugagaacugaauuccauaggcu miR-151-3p miR-151a-3p cuagacugaagcuccuugagg miR-155 miR-155-5p uuaaugcuaauc,gugauaggggu miR-1318-2* miR-181a-2-3p accacugaccguugacuguacc miR-197 miR-197-3p uucaccaccuucuccacccagc miR-204 miR-204-5p uucccuuugucauccuaugccu miR-221 miR-221-3p agcuacauugutugcuggguuuc miR-221* miR-221-5p accuggcauacaauguagauuu miR-222 miR-222-3p agcuacaucuggcuacugggu miR-328 miR-328 cuggcccucucugcccuuccgu miR-424 miR-424-5p cagcagcaauucauguuuugaa miR-551b miR-551b-3p gcgacccauacuugguuucag

The 41 FFPE samples (Set3), including 21 malignant and 20 benign thyroid neoplasms were analyzed. RT-qPCR results for each replicate of the 26 miRNA assays are summarized in Table Z2. Similarly, the 62 FNA samples (Set3) were also analyzed. RT-qPCR results for each replicate of the 26 miRNA assays are summarized in Table W2.

TABLE Z2 qRT-PCR data obtained using the third set (Set3) of FFPE samples, corresponding to benign and malignant thyroid neoplasms as described in Table Z1. Each sample was tested in duplicate. Rep 1 indicates replicate 1 and Rep 2 indicates replicate 2. The miRNAs indicated in italics were used as putative normalizers. Sample miR- miR- miR- miR- miR- miR- Name 138-1-3p 139-5p 141-3p 146b-3p 146b-5p 151-3p AF184 33.37 30.93 24.00 29.92 26.11 27.86 33.90 30.53 23.90 30.01 26.24 28.18 AF185 33.27 31.44 25.28 27.98 24.10 29.61 33.52 31.20 25.29 28.01 24.05 29.89 AF186 33.80 31.26 25.33 27.57 23.75 28.44 32.27 31.44 25.37 27.47 23.77 28.40 AF187 33.49 31.59 24.62 27.48 23.08 28.20 32.98 31.16 24.58 27.39 22.98 28.32 AF188 39.01 30.94 23.57 35.83 30.82 29.22 36.12 31.30 23.36 34.34 30.62 29.27 AF189 32.75 29.91 24.54 26.44 22.58 28.25 32.51 30.14 24.66 26.70 22.48 28.26 AF190 33.09 30.58 24.38 26.81 23.25 27.97 31.99 30.93 24.22 26.91 23.20 28.29 AF191 32.91 30.62 27.24 33.69 28.88 30.28 33.18 30.63 27.22 32.34 28.55 30.25 AF192 32.68 31.16 26.17 31.94 28.33 30.29 32.91 30.72 25.96 32.36 28.46 30.52 AF193 34.53 31.48 28.29 32.79 28.65 30.86 36.29 31.80 27.86 32.17 28.63 30.72 AF194 32.42 30.51 26.39 31.97 27.97 30.74 33.37 31.25 26.43 32.54 28.20 30.36 AF195 28.71 26.77 23.23 33.61 30.63 27.24 28.73 26.86 23.65 33.23 30.70 27.59 AF196 30.88 28.69 24.77 33.94 30.13 28.47 31.59 28.72 24.68 34.95 29.56 28.50 AF197 33.39 30.32 26.60 35.33 30.72 30.44 33.01 30.22 26.32 34.39 30.59 30.25 AF198 29.09 29.04 22.49 32.40 28.49 27.54 29.38 28.83 22.56 32.96 28.75 27.45 AF199 30.82 30.90 31.36 30.55 26.40 28.41 30.62 31.20 31.79 30.37 26.31 28.46 AF200 30.88 29.76 22.36 24.84 20.17 26.64 30.76 29.83 22.32 24.79 20.24 26.76 AF201 31.70 28.68 23.86 26.56 22.32 27.52 31.01 28.61 23.78 26.46 22.17 27.34 AF202 36.10 30.76 24.65 26.52 22.79 28.19 35.12 30.98 24.26 26.55 22.40 28.21 AF203 30.47 28.22 22.81 31.14 26.47 27.41 31.25 28.71 23.10 31.27 27.10 27.62 AF204 30.01 29.26 24.31 31.63 28.00 27.92 30.33 29.23 24.26 32.10 27.92 28.15 AF205 30.77 29.19 25.19 28.90 25.41 28.25 31.44 28.94 25.13 28.78 25.51 27.97 AF206 31.30 30.07 24.25 29.17 25.36 28.32 32.07 29.92 24.39 29.66 25.52 28.82 AF207 30.14 28.94 25.97 30.48 27.58 28.28 30.67 28.87 25.82 30.74 27.53 28.14 AF208 31.13 29.38 23.38 32.60 29.68 27.80 30.95 29.27 23.41 32.28 29.76 28.23 AF209 31.20 29.18 25.89 29.14 25.91 28.38 31.10 29.36 26.22 28.99 26.58 28.81 AF210 30.89 28.94 24.63 27.38 23.82 27.74 31.16 28.82 24.61 27.47 24.06 27.69 AF211 32.43 30.43 23.53 27.17 22.96 28.32 32.76 31.17 23.67 27.32 23.20 28.56 AF212 33.08 30.23 25.45 31.21 27.42 29.47 33.20 30.02 25.23 31.18 26.96 28.72 AF213 30.79 30.47 23.74 26.66 22.50 27.74 31.44 29.89 23.71 26.53 22.42 27.67 AF214 31.26 29.67 23.79 26.62 22.77 27.77 30.93 29.96 23.88 26.60 22.64 28.10 AF215 29.35 26.96 21.73 23.70 19.31 25.75 29.51 26.99 21.79 23.87 19.43 25.95 AF216 28.67 30.68 22.91 33.21 29.41 27.53 28.69 29.89 23.00 33.99 29.29 27.64 AF217 28.98 29.86 24.01 34.17 30.10 27.93 29.69 29.69 23.99 33.10 29.81 28.21 AF218 28.90 28.65 23.47 33.47 29.63 27.55 29.67 28.76 23.41 34.56 29.77 27.61 AF219 29.10 28.85 23.27 34.23 29.60 27.51 29.68 28.99 23.54 33.18 29.86 27.92 AF220 29.26 30.45 23.23 34.49 30.15 27.85 28.76 30.76 23.19 34.39 30.45 27.85 AF221 30.47 28.28 23.29 34.45 29.18 27.98 30.44 28.32 23.47 37.39 29.59 28.23 AF222 30.31 28.47 23.38 33.44 30.44 27.88 30.36 28.27 23.32 35.86 30.45 27.91 AF223 32.58 30.68 25.93 31.70 28.00 29.28 33.20 30.83 26.41 33.27 28.29 29.54 AF224 34.11 31.25 28.21 31.88 29.11 31.03 34.37 31.79 28.51 33.61 29.54 31.33 Sample miR- miR- miR- miR- miR- miR- Name 155 15a-5p 181a-2-3p 197-3p 19b 204-5p AF184 30.49 23.80 31.18 30.06 24.57 27.98 30.30 23.87 31.53 29.55 24.64 28.01 AF185 30.29 24.70 31.49 31.32 25.96 32.72 30.02 24.82 31.92 30.67 26.11 32.53 AF186 28.09 24.90 29.75 29.87 25.31 30.84 27.90 25.10 29.92 29.73 25.40 30.38 AF187 28.52 24.85 30.78 28.89 25.31 32.65 28.15 24.58 30.97 28.81 25.33 35.06 AF188 31.26 24.33 32.39 28.93 24.54 31.93 31.32 24.34 32.73 29.31 24.50 32.43 AF189 27.35 23.92 30.76 28.49 24.73 30.45 27.25 24.16 31.46 29.12 24.77 30.62 AF190 28.87 24.57 29.79 29.43 24.52 33.68 29.28 25.14 29.92 29.51 24.78 33.22 AF191 26.38 25.43 33.40 29.84 25.40 31.57 26.18 25.48 32.49 29.90 25.40 31.36 AF192 27.34 25.90 34.32 30.47 26.03 30.83 27.15 25.72 33.53 30.09 25.99 31.16 AF193 26.85 26.24 32.67 29.75 26.41 32.24 26.94 26.18 34.40 30.47 26.19 32.36 AF194 26.36 25.18 31.50 29.64 25.81 31.10 26.69 25.49 33.61 30.19 25.95 31.18 AF195 27.25 23.91 28.32 28.29 24.06 32.69 27.71 24.17 28.35 28.64 24.20 32.50 AF196 27.62 24.74 30.58 29.48 25.14 27.34 27.60 24.57 30.90 29.57 25.00 27.32 AF197 28.49 26.10 32.68 30.99 26.54 29.74 28.50 26.17 33.40 30.73 26.65 30.10 AF198 26.95 23.36 30.31 29.17 23.61 26.67 26.97 23.52 29.78 29.15 23.65 26.64 AF199 23.59 23.65 31.01 27.79 24.53 33.57 23.56 23.70 30.90 27.75 24.59 32.89 AF200 27.84 22.90 28.14 28.41 22.71 30.76 28.00 22.88 28.27 28.21 22.71 30.87 AF201 27.71 23.41 29.37 28.31 24.17 28.53 27.69 23.21 29.32 28.65 24.09 28.55 AF202 26.90 23.98 29.75 29.25 24.39 32.07 26.81 23.93 29.93 28.85 24.33 31.33 AF203 28.63 23.21 28.80 28.91 23.79 27.86 28.61 23.63 28.87 28.88 24.29 28.35 AF204 25.70 23.79 30.75 29.21 24.96 27.28 25.71 23.78 30.53 29.67 24.95 27.67 AF205 28.98 25.46 29.46 28.94 25.24 28.08 29.12 25.53 29.53 29.26 25.35 28.28 AF206 30.14 24.73 28.99 29.59 24.96 30.38 30.34 25.15 29.43 29.68 25.31 30.46 AF207 25.98 24.73 30.59 28.55 24.90 26.78 25.90 24.85 30.66 28.57 25.00 26.88 AF208 29.40 24.39 28.84 29.56 24.54 27.13 29.27 24.44 28.68 29.58 24.62 27.23 AF209 29.26 26.36 30.68 28.50 25.41 27.78 29.35 26.59 31.00 28.63 25.72 27.63 AF210 28.52 24.47 28.37 28.90 24.46 28.67 28.57 24.48 28.98 28.98 24.49 28.78 AF211 29.24 24.27 29.38 29.69 23.83 31.65 29.27 24.67 29.31 29.63 24.13 32.17 AF212 25.20 24.23 31.84 28.79 24.51 30.55 24.87 24.09 32.03 28.58 24.30 30.37 AF213 29.38 24.49 23.16 28.68 24.00 32.75 29.47 24.53 28.13 28.83 23.91 33.30 AF214 27.70 23.59 29.30 29.17 24.42 30.72 27.84 23.69 29.35 29.24 24.51 30.74 AF215 26.59 21.84 26.78 26.63 21.87 27.03 26.48 21.98 26.87 26.96 21.99 27.19 AF216 28.52 24.01 28.18 28.97 23.33 26.55 28.30 23.91 28.18 28.90 23.57 26.25 AF217 29.24 24.22 29.37 28.79 23.99 26.72 28.84 24.35 29.43 28.71 24.02 26.72 AF218 28.33 23.62 29.52 28.83 23.59 28.28 28.51 23.73 30.22 28.50 23.72 27.93 AF219 28.61 24.17 29.34 28.81 23.67 26.94 28.33 24.53 29.75 29.36 24.13 27.20 AF220 29.91 24.79 29.83 29.81 23.95 26.58 29.56 24.79 30.10 29.65 23.96 26.41 AF221 27.74 24.30 30.23 28.72 24.23 28.84 27.79 24.37 30.39 28.81 24.31 28.78 AF222 29.24 24.61 30.72 29.19 24.28 27.32 29.15 24.62 30.57 29.15 24.46 27.31 AF223 25.48 24.55 31.88 29.54 24.54 29.73 25.72 24.72 32.30 29.53 24.82 29.59 AF224 27.60 26.28 32.51 30.28 26.66 31.67 27.66 26.78 32.53 30.10 26.78 31.96 Sample miR- miR- miR- miR- miR- miR- Name 21-5p 221-3p 221-5p 222-3p 29b-1* 29b-3p AF184 22.60 23.61 30.03 22.63 30.74 25.78 22.81 23.84 29.41 22.80 29.97 25.75 AF185 23.18 24.52 30.32 22.93 30.99 27.31 22.93 24.53 31.22 22.88 31.24 27.20 AF186 21.60 24.18 30.28 22.85 31.39 26.77 21.73 24.31 30.43 22.88 31.90 26.87 AF187 20.58 24.16 30.49 22.18 30.97 26.02 20.58 24.11 29.40 22.14 29.80 25.77 AF188 21.77 28.96 33.38 27.47 30.49 24.58 21.80 29.34 32.95 26.56 30.01 25.07 AF189 20.22 23.71 29.84 22.46 29.54 25.63 20.61 23.65 30.07 22.46 30.25 25.72 AF190 20.77 23.92 31.25 22.45 30.46 27.02 21.06 23.82 30.43 22.60 30.76 26.70 AF191 22.86 28.11 33.88 25.99 31.65 27.45 22.73 28.11 33.34 26.01 31.54 27.22 AF192 22.07 28.45 34.16 26.35 31.20 27.33 22.16 28.39 33.69 26.26 31.36 27.20 AF193 23.19 28.01 33.31 26.00 32.22 28.20 23.12 27.93 33.63 26.35 31.77 28.13 AF194 21.69 26.90 32.77 25.79 31.73 27.16 21.82 27.12 34.87 25.98 31.79 27.34 AF195 21.75 25.80 33.79 25.74 31.65 26.41 22.16 26.27 34.92 26.22 32.56 26.82 AF196 22.51 28.58 33.84 27.10 30.87 27.13 22.41 28.66 34.36 27.18 30.62 26.83 AF197 23.73 28.91 35.09 27.33 34.11 28.33 23.76 28.89 38.69 27.57 31.81 27.88 AF198 21.51 27.39 32.41 25.71 29.54 25.21 21.68 27.61 32.26 25.79 29.90 21.37 AF199 19.45 24.96 32.54 25.36 31.36 27.25 19.48 25.17 32.92 25.41 31.35 27.08 AF200 19.20 21.92 27.07 20.51 29.42 23.69 19.23 21.96 27.14 20.54 29.41 23.59 AF201 21.52 23.31 28.85 21.87 30.20 24.87 21.37 23.14 28.93 21.84 30.20 24.62 AF202 20.11 24.56 32.29 22.62 31.73 25.94 20.35 24.40 30.48 22.58 30.79 25.14 AF203 21.98 24.13 29.89 23.18 30.08 25.20 22.25 24.53 30.06 23.48 30.49 25.63 AF204 21.17 27.98 32.91 26.31 30.74 26.32 21.26 28.12 33.95 26.24 30.93 26.42 AF205 23.53 24.61 30.35 23.84 30.14 26.70 23.61 24.79 30.57 24.34 30.90 26.77 AF206 23.62 24.92 31.05 24.00 30.83 25.83 24.10 25.34 31.27 24.22 31.49 26.14 AF207 21.91 26.61 32.85 26.36 30.31 26.42 22.20 26.71 32.47 26.20 30.15 26.53 AF208 22.60 22.76 29.38 22.45 31.78 25.42 22.67 22.76 29.68 22.36 30.76 25.62 AF209 23.63 25.34 32.92 24.70 30.57 27.58 23.97 25.88 32.56 24.98 30.44 27.57 AF210 20.92 23.92 30.30 22.71 30.37 26.14 20.90 23.99 30.25 22.82 30.22 26.37 AF211 21.15 24.56 29.81 21.69 29.86 25.63 21.36 24.88 30.26 21.83 30.15 26.13 AF212 21.14 27.50 33.12 25.46 31.51 26.52 20.88 27.01 32.31 25.21 30.91 25.97 AF213 21.01 22.92 29.45 21.94 30.33 25.51 20.99 22.77 29.13 21.88 29.96 25.31 AF214 20.96 23.58 29.12 22.16 30.14 25.14 21.32 23.77 29.21 22.18 30.50 25.30 AF215 18.89 22.86 28.48 21.59 27.98 22.83 19.00 23.13 28.22 21.68 27.99 22.96 AF216 21.58 25.49 31.04 24.08 29.82 25.54 21.62 25.69 29.91 23.67 30.12 25.69 AF217 22.74 24.74 30.78 23.88 29.65 25.87 22.73 24.69 29.97 24.02 29.82 25.86 AF218 22.38 26.60 32.41 24.55 29.79 25.25 22.30 26.50 31.12 24.60 29.39 24.86 AF219 22.17 26.73 30.69 24.42 29.77 25.18 22.43 26.63 31.78 24.68 29.77 25.76 AF220 22.87 26.61 30.91 24.65 29.83 24.97 22.85 26.71 30.61 24.68 29.84 25.13 AF221 22.25 26.33 31.66 25.37 29.77 25.28 22.48 26.69 31.41 25.35 29.87 25.56 AF222 22.75 27.65 32.54 26.46 30.43 25.57 22.66 27.35 32.20 26.61 29.99 25.68 AF223 21.70 27.76 33.53 25.55 31.36 26.53 21.83 28.43 33.72 25.76 31.56 26.87 AF224 22.84 28.64 35.25 27.09 32.26 27.79 23.23 29.15 34.07 27.24 31.70 28.08 Sample miR- miR- miR- miR- miR- miR- Name 31-5p 328 34a 375 424-5p 551b-3p AF184 23.91 29.47 25.09 30.85 27.10 26.12 23.63 29.29 24.90 30.88 27.13 25.93 AF185 29.26 30.54 26.15 29.95 26.54 31.18 29.23 30.63 26.34 29.40 26.88 32.35 AF186 24.88 28.72 25.71 28.23 25.68 27.41 25.12 28.84 25.98 28.39 25.77 27.80 AF187 25.53 28.63 24.86 28.47 26.54 28.41 25.42 28.75 24.81 28.63 26.40 28.24 AF188 30.45 29.42 24.25 31.51 28.21 40.29 30.15 29.48 24.23 31.61 28.42 38.28 AF189 26.67 28.29 24.62 28.13 25.11 27.40 27.16 28.22 24.99 28.22 25.33 27.96 AF190 27.47 28.49 25.15 31.18 25.54 29.71 27.49 28.52 25.50 31.58 25.76 28.72 AF191 29.31 30.85 28.09 31.89 27.75 32.70 29.12 31.45 27.65 33.21 27.82 33.22 AF192 27.64 31.44 27.44 35.55 26.81 34.94 27.57 31.15 27.29 35.47 26.72 33.62 AF193 28.91 31.12 28.24 34.39 27.85 34.74 28.79 30.57 27.87 33.85 27.69 32.35 AF194 27.90 30.29 26.71 41.82 26.87 37.87 28.36 31.69 27.18 41.91 27.17 32.58 AF195 30.20 29.30 26.31 33.39 24.93 30.17 30.39 29.86 26.65 35.30 25.44 31.09 AF196 29.15 29.54 26.80 34.66 25.24 33.52 28.80 29.59 26.45 34.58 24.96 32.93 AF197 30.78 31.49 27.41 34.28 26.94 35.53 30.88 31.90 27.64 34.49 26.84 32.98 AF198 29.50 28.61 24.47 31.80 24.42 32.76 29.55 28.48 24.56 31.52 24.47 32.54 AF199 26.74 29.64 25.54 43.36 24.86 32.38 26.83 30.19 25.44 41.80 24.95 32.30 AF200 22.70 28.46 23.45 26.27 21.64 24.91 22.65 28.45 23.39 26.04 21.74 24.95 AF201 23.72 28.16 24.91 29.25 22.74 27.49 23.49 28.18 24.66 28.98 22.68 27.43 AF202 24.20 28.90 24.82 27.94 25.23 27.17 23.93 29.15 25.00 27.75 25.37 27.09 AF203 30.73 28.12 25.46 26.69 22.59 34.30 30.58 28.18 25.80 27.00 23.09 33.19 AF204 29.67 29.55 26.16 37.80 24.71 32.37 29.50 29.95 26.22 34.75 24.92 36.36 AF205 26.94 28.33 26.77 27.28 26.78 29.62 26.90 27.78 26.73 27.47 26.12 29.86 AF206 31.02 45.00 26.24 27.66 27.60 31.92 30.62 28.67 26.61 27.76 27.90 32.69 AF207 27.55 28.51 25.95 33.88 26.35 32.53 27.51 28.61 25.93 32.82 26.46 32.41 AF208 25.52 29.53 25.41 31.66 24.26 24.62 25.86 29.39 25.60 31.50 24.45 24.65 AF209 27.74 27.49 26.42 29.38 26.41 30.26 27.51 27.55 27.00 29.56 26.78 30.58 AF210 25.28 28.46 25.24 28.43 24.34 27.26 25.24 28.36 25.06 28.18 24.49 27.52 AF211 26.79 29.11 25.44 27.26 27.70 27.14 26.75 29.31 25.67 27.64 28.38 27.45 AF212 27.72 29.98 26.74 33.51 25.96 32.37 27.34 29.40 26.54 31.52 25.78 30.82 AF213 24.95 28.27 24.65 26.66 24.14 25.87 25.07 28.16 24.70 26.67 24.15 26.09 AF214 23.40 28.55 24.45 24.89 26.70 26.72 23.38 28.44 24.77 26.34 26.85 26.82 AF215 22.11 26.20 23.71 24.27 20.96 24.38 22.26 26.28 23.86 24.39 21.01 24.53 AF216 29.09 27.94 24.95 30.97 23.41 31.20 29.26 27.80 24.90 32.34 23.45 31.81 AF217 29.74 28.14 25.09 32.87 25.36 30.03 29.89 28.17 24.95 31.86 25.24 29.78 AF218 28.24 28.60 25.28 30.85 23.43 30.96 27.87 28.50 25.39 30.84 23 57 30.55 AF219 30.24 27.95 24.61 31.50 24.53 31.38 30.24 28.14 24.98 32.68 24.78 33.54 AF220 28.08 28.66 25.22 34.30 23.62 32.39 27.87 28.80 25.36 34.63 24.61 31.15 AF221 27.84 28.44 25.79 29.48 23.79 30.95 27.89 28.36 25.99 29.82 23.99 32.01 AF222 30.34 28.45 25.31 32.21 24.86 32.15 30.55 28.51 25.12 33.83 24.64 33.82 AF223 27.94 30.49 27.22 32.20 26.26 32.45 28.39 30.61 27.35 32.49 26.47 34.59 AF224 29.34 30.72 27.78 35.15 28.13 34.65 29.27 31.12 27.83 35.55 28.13 34.75 Sample miR- miR- Name 7-5p 96-5p AF184 32.38 28.58 31.25 28.68 AF185 35.62 32.95 36.76 32.45 AF186 33.26 31.61 33.76 31.99 AF187 32.38 31.18 32.15 30.62 AF188 32.73 28.32 32.14 28.62 AF189 30.31 30.76 30.60 31.78 AF190 33.43 30.53 33.47 30.81 AF191 32.65 33.97 32.11 35.30 AF192 33.98 32.93 33.54 32.53 AF193 33.82 34.25 33.85 34.15 AF194 32.61 32.91 32.93 32.66 AF195 31.89 35.36 32.40 35.80 AF196 27.37 30.67 27.17 30.22 AF197 28.29 31.70 27.90 32.02 AF198 27.71 29.48 28.17 29.39 AF199 30.27 32.55 29.74 32.64 AF200 31.66 29.82 32.09 29.87 AF201 28.55 30.13 28.21 29.97 AF202 33.47 31.66 31.50 31.27 AF203 27.77 29.53 28.47 29.93 AF204 28.84 29.99 28.56 30.01 AF205 28.61 32.34 28.66 32.19 AF206 29.65 31.17 30.18 31.84 AF207 30.48 31.44 30.57 31.88 AF208 31.18 30.25 31.12 30.58 AF209 29.73 33.16 30.08 33.73 AF210 27.92 31.79 27.60 31.19 AF211 33.23 32.44 34.20 32.56 AF212 31.46 31.87 31.50 31.54 AF213 31.84 31.78 31.80 31.79 AF214 29.78 30.45 30.72 30.76 AF215 27.81 28.67 27.76 28.84 AF216 25.33 29.90 24.88 29.76 AF217 28.41 29.89 28.37 30.19 AF218 24.78 30.60 24.35 30.88 AF219 25.72 30.21 26.14 30.75 AF220 25.17 30.69 24.85 30.90 AF221 28.00 29.65 28.25 30.03 AF222 28.46 30.17 28.26 29.69 AF223 31.77 32.53 32.44 35.27 AF224 33.52 33.20 34.45 32.84

TABLE W2 miR- Sample ID 138-1-3p miR-139-5p miR-141-3p miR-146b-3p FNA-T1 29.686714 27.247915 23.298391 23.720663 FNA-T1 29.66181 27.374592 23.236439 23.762691 FNA-T10 33.610046 32.17644 27.20892 26.287708 FNA-T10 32.77893 31.632158 27.216581 26.069279 FNA-T11 34.85763 34.542107 28.939924 28.889807 FNA-T11 34.45797 35.284443 29.184425 29.125067 FNA-T12 34.113934 32.123882 25.513596 27.645618 FNA-T12 33.71167 33.661522 25.607426 27.720995 FNA-T13 35.781925 31.772648 24.466602 25.980343 FNA-T13 33.83142 31.801874 24.428434 25.918755 FNA-T14 31.794363 30.458538 25.926065 25.942867 FNA-T14 32.492924 29.800528 26.113035 25.78877 FNA-T15 31.875889 28.51506 27.280334 30.194223 FNA-T15 31.78392 28.689842 27.146084 30.138336 FNA-T16 32.932526 31.41135 27.525618 27.007025 FNA-T16 33.03669 33.427067 27.685963 27.152893 FNA-T17 30.957563 29.474812 23.295797 25.131533 FNA-T17 31.223692 29.525341 23.461391 25.27709 FNA-T18 32.8673 31.442698 27.58398 26.296366 FNA-T18 33.00814 32.19118 27.509956 26.396751 FNA-T19 31.111235 29.396866 24.659824 23.909304 FNA-T19 31.434946 29.203545 24.664917 23.905048 FNA-T2 31.980186 30.384403 27.85435 31.246332 FNA-T2 32.488434 30.61042 28.185389 30.63359 FNA-T20 30.106356 28.865314 24.599226 32.45335 FNA-T20 30.381126 28.741804 24.478662 32.29998 FNA-T21 30.102598 28.16299 24.108892 25.423674 FNA-T21 30.244219 28.410114 23.934332 25.590101 FNA-T22 31.478653 32.62077 26.917446 27.792574 FNA-T22 31.91722 32.284798 26.694897 27.384892 FNA-T23 30.931576 29.706663 24.101965 27.32051 FNA-T23 30.792831 30.137056 23.953304 26.976732 FNA-T24 31.998234 29.29144 26.961124 33.33903 FNA-T24 32.08647 29.505066 27.351202 33.17794 FNA-T25 32.426994 32.362892 28.1807 31.197384 FNA-T25 32.599224 29.722988 28.310392 31.630665 FNA-T26 32.400253 30.824299 27.49206 33.15483 FNA-T26 33.65451 30.500172 27.622587 32.093754 FNA-T27 32.102573 30.848007 27.20775 30.494226 FNA-T27 32.10568 30.899002 27.281246 30.511189 FNA-T28 31.981346 29.08321 25.901917 32.184334 FNA-T28 32.593918 28.773298 25.767479 32.46334 FNA-T29 29.535822 29.254395 23.848276 32.73343 FNA-T29 29.635082 29.272427 24.182951 32.792492 FNA-T3 32.538258 29.912996 25.642756 32.796402 FNA-T3 31.945688 29.87382 25.800848 33.460773 FNA-T30 30.541605 28.517384 24.828289 32.427128 FNA-T30 30.92708 28.607445 25.17766 34.77237 FNA-T31 29.869715 31.146616 27.003883 31.084644 FNA-T31 29.721697 30.19459 26.63451 29.971098 FNA-T32 37.196377 31.862574 27.661999 Undetermined FNA-T32 34.52026 33.11717 27.899796 35.803516 FNA-T33 28.37062 29.169825 23.765234 31.671144 FNA-T33 28.735172 29.671164 24.0439 31.66935 FNA-T34 33.445362 31.597311 26.182804 33.784332 FNA-T34 32.082203 31.9434 25.829365 33.603394 FNA-T35 29.741611 29.717335 25.482199 31.869898 FNA-T35 29.681551 29.868559 25.616343 32.157448 FNA-T36 33.54916 32.003017 28.601177 33.726288 FNA-T36 33.221252 32.413284 28.297396 33.929947 FNA-T37 32.722103 29.315485 25.895226 34.312267 FNA-T37 31.734703 29.285511 26.230925 33.356644 FNA-T38 28.73019 26.1435 25.165466 31.289324 FNA-T38 28.965206 26.151163 25.321548 32.214836 FNA-T39 31.352875 29.358044 26.886892 31.125448 FNA-T39 30.429163 29.271496 25.186626 30.990368 FNA-T4 33.19305 32.144253 28.6505 30.507126 FNA-T4 34.16581 30.25454 28.491386 30.651333 FNA-T40 30.550085 30.673561 26.165552 33.257618 FNA-T40 31.080975 30.664106 26.151747 33.51381 FNA-T41 30.562462 28.952232 25.97411 31.680597 FNA-T41 31.16829 28.875553 26.17238 32.236702 FNA-T42 30.624987 27.908648 24.428516 25.571127 FNA-T42 30.658573 27.445137 24.389067 25.594055 FNA-T43 30.00317 27.26614 23.334663 24.188713 FNA-T43 29.850477 27.505629 23.338024 24.257338 FNA-T44 30.574074 29.157316 22.70063 23.928938 FNA-T44 30.349606 28.867634 22.586786 23.822565 FNA-T45 32.90401 31.363914 28.723019 26.445185 FNA-T45 33.089054 31.256847 28.531202 26.53614 FNA-T46 30.945957 28.765219 22.778337 23.918518 FNA-T46 30.871307 28.85428 22.668093 23.98527 FNA-T47 30.607052 30.209711 25.370367 27.159512 FNA-T47 30.79872 30.541962 25.366777 27.207943 FNA-T48 31.33223 30.207405 25.478212 24.181093 FNA-T48 31.012167 30.255873 25.515608 24.226221 FNA-T49 30.818712 28.274742 24.313276 24.373377 FNA-T49 32.194633 27.943735 24.212631 24.296938 FNA-T5 32.405037 28.555017 27.167114 29.384792 FNA-T5 31.89376 28.703918 27.190718 29.46035 FNA-T50 30.527687 28.470112 24.317799 25.720697 FNA-T50 30.176064 28.373278 24.334843 25.726728 FNA-T51 30.870789 28.721737 24.761866 24.236048 FNA-T51 30.63485 29.45917 24.92758 24.526176 FNA-T52 29.374151 28.440987 22.705618 26.206436 FNA-T52 29.321453 28.479843 22.820032 26.28629 FNA-T53 33.202103 29.906212 27.915926 32.233067 FNA-T53 31.661749 29.735195 27.926538 31.778103 FNA-T54 31.703917 29.97529 27.210884 34.27559 FNA-T54 32.103035 29.599464 27.247477 33.553905 FNA-T55 31.507004 28.198795 25.245266 31.651506 FNA-T55 30.746473 27.802738 24.952003 31.818302 FNA-T56 34.315556 32.289394 25.77568 34.346485 FNA-T56 34.449806 33.10517 25.910244 35.411453 FNA-T57 32.83361 30.722061 24.821531 28.7195 FNA-T57 31.372488 30.59778 24.864733 28.526976 FNA-T58 31.128708 28.178057 28.412926 33.540627 FNA-T58 30.967634 28.466677 28.631424 34.370808 FNA-T59 30.877525 29.4581 25.55062 25.727354 FNA-T59 30.99779 29.486015 25.751541 25.748922 FNA-T6 31.995312 31.7296 27.498919 35.970116 FNA-T6 32.391037 32.419277 27.872248 35.623577 FNA-T60 34.730118 31.15454 26.375692 Undetermined FNA-T60 32.970734 30.487375 26.474897 35.450314 FNA-T61 31.383772 31.811224 26.245752 32.74382 FNA-T61 31.403366 31.867811 26.596395 35.20468 FNA-T62 30.78053 30.018875 25.911264 35.736336 FNA-T62 30.81902 30.542652 25.900553 33.17349 FNA-T7 31.494045 29.200693 26.626982 27.406225 FNA-T7 31.402466 29.446598 26.651577 27.489912 FNA-T8 32.83336 28.213581 25.212255 25.867922 FNA-T8 32.586514 28.385561 25.362967 25.944284 FNA-T9 35.19928 32.9607 30.458836 34.483185 FNA-T9 33.972744 33.5527 31.345991 34.213585 Sample ID miR-146b-5p miR-151-3p miR-155 miR-15a-5p FNA-T1 20.532497 23.720423 23.397497 17.395332 FNA-T1 20.545517 23.844328 23.497507 17.452892 FNA-T10 25.24384 27.355364 28.774397 21.807444 FNA-T10 24.460548 27.264843 28.968596 21.666267 FNA-T11 27.978056 28.215204 26.409773 21.950428 FNA-T11 28.236816 28.395224 26.613869 22.267273 FNA-T12 25.318787 29.48024 30.908276 24.910538 FNA-T12 25.46194 29.567608 30.785582 24.807781 FNA-T13 23.385855 28.561462 26.950827 23.2032 FNA-T13 23.349695 28.480206 26.960596 23.313564 FNA-T14 24.594042 28.338284 30.142021 24.866877 FNA-T14 24.406065 28.2445 29.90064 24.846542 FNA-T15 28.103964 24.106462 26.935848 18.304169 FNA-T15 28.44457 23.958496 27.020933 18.511219 FNA-T16 27.736053 29.234398 33.175297 23.255949 FNA-T16 26.794262 29.27337 31.58349 23.282183 FNA-T17 22.982538 26.318102 25.135504 23.430061 FNA-T17 22.894547 26.406599 25.233057 23.517857 FNA-T18 25.324505 28.834984 26.238739 25.818779 FNA-T18 25.752193 29.163809 26.275812 25.886168 FNA-T19 22.844242 27.09977 29.678366 24.440128 FNA-T19 22.779215 27.06503 29.27977 24.542385 FNA-T2 29.205395 27.61581 25.472637 23.16486 FNA-T2 29.307468 27.85993 25.698673 23.274725 FNA-T20 29.452393 25.752836 28.163557 19.300997 FNA-T20 29.30013 25.739996 27.755651 19.213083 FNA-T21 23.882595 26.676023 26.910845 23.411472 FNA-T21 23.849615 26.81944 26.901575 23.554602 FNA-T22 26.525532 27.649153 29.901728 22.168571 FNA-T22 26.538591 27.584732 29.374508 22.292957 FNA-T23 25.355679 25.70668 25.798903 20.72359 FNA-T23 25.098497 25.781 25.591196 20.421762 FNA-T24 31.655443 27.836647 29.566021 21.991768 FNA-T24 31.494802 28.272316 29.88115 22.22226 FNA-T25 29.921268 27.33637 27.2154 21.351002 FNA-T25 30.059465 27.529253 27.259384 21.64143 FNA-T26 30.944326 28.775505 28.623587 22.730553 FNA-T26 30.618221 28.751554 28.746346 22.885683 FNA-T27 29.5818 28.68144 28.439346 24.10121 FNA-T27 29.748611 28.861916 28.642506 23.982159 FNA-T28 30.305853 27.837112 25.967134 21.383492 FNA-T28 30.086035 27.574003 25.797411 21.442741 FNA-T29 30.520782 26.770647 29.989164 22.250774 FNA-T29 30.314692 26.75742 30.370378 22.28899 FNA-T3 30.725107 27.690231 29.522203 21.497208 FNA-T3 30.949142 27.543365 29.654066 21.57565 FNA-T30 30.807035 26.206888 29.31309 20.311813 FNA-T30 30.943573 26.197397 29.412018 20.378456 FNA-T31 29.3972 27.653997 27.73402 22.430922 FNA-T31 28.985794 27.39575 27.860409 22.122993 FNA-T32 32.19736 27.685831 31.223785 20.859383 FNA-T32 32.456356 27.931112 31.86898 21.35533 FNA-T33 29.434418 25.925068 29.998503 21.138245 FNA-T33 30.254755 26.221485 30.233063 21.451023 FNA-T34 30.67846 27.296001 29.32363 21.798595 FNA-T34 31.00535 27.430798 29.584566 21.822613 FNA-T35 30.513634 26.846313 28.36747 20.32238 FNA-T35 30.618778 26.887613 28.317791 20.414942 FNA-T36 32.082962 29.915424 29.71966 22.997276 FNA-T36 32.090916 29.670103 29.26421 23.025518 FNA-T37 30.94133 26.748241 28.763447 21.065388 FNA-T37 31.25862 26.725689 29.277992 21.16831 FNA-T38 34.353374 27.199493 28.505981 25.332064 FNA-T38 34.774017 27.351727 28.497934 25.244667 FNA-T39 29.368946 26.574303 26.915857 19.811405 FNA-T39 29.085936 26.626427 27.14496 19.929224 FNA-T4 29.275595 27.655647 25.40957 21.16699 FNA-T4 29.526566 27.638578 25.32429 21.207483 FNA-T40 31.564825 27.700035 29.315458 21.58901 FNA-T40 31.643892 27.716877 28.884947 21.5213 FNA-T41 30.922012 26.756815 28.485174 20.583536 FNA-T41 30.98264 26.898712 28.77016 20.82358 FNA-T42 22.755472 24.281397 24.092228 17.618967 FNA-T42 22.523087 24.153524 23.84154 17.572567 FNA-T43 21.671013 24.299393 26.105927 19.262407 FNA-T43 21.783876 24.278673 25.992552 19.234812 FNA-T44 21.151045 25.507265 27.515324 21.424637 FNA-T44 21.030365 25.459078 27.542799 21.428375 FNA-T45 27.29478 28.799063 31.007568 22.857424 FNA-T45 27.359974 28.917706 31.876291 22.96709 FNA-T46 24.300142 25.858658 28.52694 19.13223 FNA-T46 21.728031 25.901863 28.569756 19.261362 FNA-T47 25.53313 27.835642 30.756876 24.522694 FNA-T47 25.800882 27.890217 30.398163 24.451723 FNA-T48 23.571497 27.148775 29.730305 25.396801 FNA-T48 23.46953 27.211584 30.114784 25.466698 FNA-T49 22.075262 25.603071 25.10628 19.510986 FNA-T49 21.893274 25.66718 25.01344 19.458557 FNA-T5 28.515465 26.384024 26.45084 20.669962 FNA-T5 28.667355 26.593912 26.410242 20.694485 FNA-T50 23.493168 24.545803 27.133133 18.219131 FNA-T50 23.74096 24.553919 27.315342 18.350636 FNA-T51 23.605844 26.550951 29.172537 23.494295 FNA-T51 23.763407 26.883968 29.42887 23.729527 FNA-T52 23.694386 25.307146 25.719387 20.97136 FNA-T52 23.636364 25.319677 25.82726 21.015167 FNA-T53 30.59159 26.853363 28.739058 20.795107 FNA-T53 31.237247 26.843718 28.837276 20.91187 FNA-T54 31.353594 27.005735 30.271217 19.524746 FNA-T54 31.541918 26.831339 30.824812 19.676071 FNA-T55 29.907467 25.93737 28.899256 19.729116 FNA-T55 30.54798 25.930876 28.859764 19.937914 FNA-T56 32.533268 27.8079 31.30899 20.543272 FNA-T56 32.76386 27.981945 31.675732 20.627884 FNA-T57 26.819609 28.381905 30.426289 22.923357 FNA-T57 26.662947 28.251654 30.812857 23.018944 FNA-T58 29.776308 25.52434 27.486877 19.55204 FNA-T58 29.873936 25.982357 27.818792 19.82805 FNA-T59 24.736164 27.709654 27.119335 22.795462 FNA-T59 24.635582 28.006199 27.107613 22.847567 FNA-T6 33.183666 28.807083 31.282656 22.748539 FNA-T6 33.672558 28.952227 31.653599 23.173307 FNA-T60 31.64863 28.4077 31.640816 19.682795 FNA-T60 31.589708 28.475708 31.197052 19.749275 FNA-T61 32.605984 28.393358 29.68497 22.528143 FNA-T61 32.77558 28.715664 30.435673 22.693125 FNA-T62 31.788069 28.129845 30.736885 21.967327 FNA-T62 32.36156 28.234833 30.76271 22.301533 FNA-T7 26.470524 27.314032 25.543707 22.182627 FNA-T7 26.692406 27.38797 25.587519 22.293215 FNA-T8 32.04267 26.689198 25.81281 21.58136 FNA-T8 24.715437 26.9592 25.496908 21.70281 FNA-T9 34.81624 29.538303 32.40396 23.187382 FNA-T9 34.547188 29.821249 32.94409 23.511566 miR- Sample ID 181a-2-3p miR-197-3p miR-19b miR-204-5p FNA-T1 26.239046 23.791225 17.215101 29.735453 FNA-T1 26.236746 23.952164 17.333632 30.533972 FNA-T10 29.457657 26.932486 21.622456 33.77057 FNA-T10 29.482769 26.577967 21.461847 33.342205 FNA-T11 30.944098 26.777277 22.610968 35.810627 FNA-T11 31.247454 26.703016 22.768736 34.085926 FNA-T12 30.680006 29.121956 24.657997 33.690598 FNA-T12 30.929245 28.512478 24.88813 34.141846 FNA-T13 30.30806 27.272444 23.540218 32.731987 FNA-T13 30.5223 27.231318 23.569202 32.784172 FNA-T14 28.702656 27.975029 24.873064 32.2442 FNA-T14 28.871883 28.399105 24.850115 31.91132 FNA-T15 29.492765 24.925266 18.616865 29.414454 FNA-T15 29.692642 24.977236 18.670918 29.272732 FNA-T16 29.904036 28.346355 23.424759 32.863037 FNA-T16 30.700163 28.162886 23.540562 31.896528 FNA-T17 28.39143 26.315237 23.557722 31.1135 FNA-T17 28.454716 26.630678 23.734999 31.160854 FNA-T18 31.297668 27.64463 25.664581 32.427624 FNA-T18 31.452131 27.652357 25.911089 32.542015 FNA-T19 27.497894 26.844429 24.421219 30.931953 FNA-T19 27.467567 27.216856 24.436321 30.70659 FNA-T2 31.882801 27.329395 23.14852 30.513096 FNA-T2 31.733582 27.27619 23.3389 30.86093 FNA-T20 30.207386 26.991385 19.413057 26.810284 FNA-T20 29.866316 26.816502 19.476957 26.615961 FNA-T21 27.14218 26.105713 23.510206 30.704092 FNA-T21 27.282236 26.233751 23.57707 30.993202 FNA-T22 28.833063 28.603338 22.602016 33.345787 FNA-T22 28.577223 28.574562 22.571129 33.382484 FNA-T23 28.38265 26.353848 20.791359 31.733624 FNA-T23 28.250664 26.188334 20.766026 31.856928 FNA-T24 30.679192 28.10714 22.151901 27.877872 FNA-T24 30.588951 28.108578 22.31967 27.731865 FNA-T25 31.554508 26.076218 21.378325 28.55321 FNA-T25 31.55156 26.29985 21.640467 28.69519 FNA-T26 31.569275 27.612509 22.94717 29.080849 FNA-T26 31.422535 27.653923 23.507088 29.325119 FNA-T27 30.772295 27.185225 24.07127 29.74005 FNA-T27 31.474485 26.879963 23.994165 29.915297 FNA-T28 32.221565 27.801239 21.547987 30.10192 FNA-T28 32.223766 27.523092 21.499022 30.081406 FNA-T29 30.479488 26.960232 22.53613 24.089521 FNA-T29 30.743345 26.991112 22.637787 23.956926 FNA-T3 29.848053 27.721497 21.583067 28.12065 FNA-T3 29.577131 27.96883 21.688324 28.204988 FNA-T30 29.831251 27.168604 20.693306 26.063478 FNA-T30 29.909483 27.596775 20.839579 26.348583 FNA-T31 30.244614 26.145866 22.69481 27.859968 FNA-T31 29.55648 25.980295 22.60781 27.642803 FNA-T32 35.14281 28.980658 20.867188 29.37276 FNA-T32 33.353256 29.262188 21.192448 29.305498 FNA-T33 26.909027 26.601334 21.291773 24.374651 FNA-T33 27.300104 26.71459 21.579449 24.600601 FNA-T34 29.98888 27.061102 21.733154 25.86781 FNA-T34 29.972055 27.103056 21.734434 25.870594 FNA-T35 29.187536 27.233412 20.83039 26.77417 FNA-T35 29.484724 27.14771 20.96967 26.794481 FNA-T36 31.724634 28.590982 23.671719 29.853868 FNA-T36 32.296886 28.40818 23.672071 29.847422 FNA-T37 31.885494 25.628588 20.787703 30.26648 FNA-T37 31.921024 25.494148 21.00772 30.246279 FNA-T38 27.619493 27.23486 23.98677 28.797356 FNA-T38 27.655455 26.96634 24.14323 29.008282 FNA-T39 29.547138 26.197433 20.368402 30.471426 FNA-T39 29.659397 26.216265 20.430325 30.163635 FNA-T4 32.777424 27.100462 21.702898 31.907082 FNA-T4 30.997013 26.942728 21.742785 31.801085 FNA-T40 30.683807 27.295164 21.915226 27.718126 FNA-T40 30.43888 27.420246 21.96684 27.923742 FNA-T41 29.975554 26.63543 21.192091 29.858027 FNA-T41 30.231993 26.663046 21.365736 29.771774 FNA-T42 28.181196 25.088528 17.540688 28.736517 FNA-T42 28.244263 24.969404 17.44289 28.689404 FNA-T43 26.088053 25.679552 18.882652 29.305132 FNA-T43 25.941563 25.684647 18.97493 29.32449 FNA-T44 26.769348 26.412367 21.882946 27.958933 FNA-T44 26.748264 26.336475 21.766151 27.72356 FNA-T45 30.667646 26.161797 23.105068 32.117153 FNA-T45 30.681046 26.34453 23.260078 33.20252 FNA-T46 28.437214 25.97021 18.998446 30.353168 FNA-T46 28.48834 26.142548 19.157124 30.663158 FNA-T47 28.913853 28.50871 24.336916 29.648561 FNA-T47 29.481346 28.616205 24.555311 29.680964 FNA-T48 27.710281 26.409561 25.145098 30.204496 FNA-T48 27.667358 26.227879 25.005325 30.325666 FNA-T49 28.15067 26.486704 20.154232 29.780933 FNA-T49 27.896036 26.33218 20.15728 29.964594 FNA-T5 30.47705 25.745754 20.946533 28.334478 FNA-T5 29.970358 25.89298 20.989868 28.421026 FNA-T50 27.48278 25.590887 18.3425 30.62756 FNA-T50 27.298765 25.611038 18.489569 30.58245 FNA-T51 27.649504 25.991215 23.777613 29.084648 FNA-T51 27.655264 26.229612 23.873423 29.259912 FNA-T52 26.85997 26.158352 21.346916 27.838436 FNA-T52 27.010382 26.081982 21.448828 27.755262 FNA-T53 31.601341 26.518251 21.133186 28.466084 FNA-T53 30.921926 26.512085 21.311647 28.488344 FNA-T54 31.869246 27.203337 19.957684 30.296206 FNA-T54 32.72795 26.949951 19.862558 30.151691 FNA-T55 28.993805 26.964731 20.115822 25.171743 FNA-T55 28.949444 26.89224 20.209393 25.200478 FNA-T56 33.565117 29.159819 20.358751 29.953836 FNA-T56 34.022488 29.426474 20.589308 30.399946 FNA-T57 29.662863 28.54691 23.496655 28.020273 FNA-T57 29.643246 28.857246 23.477638 27.831347 FNA-T58 30.491571 27.49442 19.653465 27.744125 FNA-T58 30.896376 27.697884 19.78614 27.77092 FNA-T59 29.239832 27.87485 23.317558 29.15248 FNA-T59 29.286037 27.791822 23.261757 28.877626 FNA-T6 31.562769 27.687021 23.473692 27.709042 FNA-T6 31.654436 27.844822 23.701212 28.101784 FNA-T60 33.682297 29.32063 20.390467 30.341618 FNA-T60 33.276573 29.490606 20.46086 30.88486 FNA-T61 32.13518 28.759398 22.932732 30.297083 FNA-T61 31.532003 28.680769 23.182756 30.131485 FNA-T62 31.512766 27.54955 22.434282 27.451754 FNA-T62 31.26316 27.66141 22.63109 27.578077 FNA-T7 29.442358 26.65219 22.461542 28.639988 FNA-T7 29.55025 26.73802 22.540699 28.737852 FNA-T8 28.464312 26.31842 21.490355 28.839254 FNA-T8 28.75942 26.371647 21.61542 28.951405 FNA-T9 33.719215 27.948347 23.56581 32.99965 FNA-T9 33.411324 28.453445 23.893435 33.132107 Sample ID miR-21-5p miR-221-3p miR-221-5p miR-222-3p FNA-T1 16.642141 21.357765 27.328987 19.84434 FNA-T1 16.827057 21.320906 27.682508 19.934328 FNA-T10 24.675112 24.95443 31.58463 23.74235 FNA-T10 24.113333 24.584356 32.377167 23.405302 FNA-T11 22.721924 26.949018 34.3314 25.289131 FNA-T11 22.729729 27.275375 33.760258 25.51431 FNA-T12 22.634512 27.818203 32.1954 24.979237 FNA-T12 22.700262 27.654505 33.073463 25.243189 FNA-T13 20.864109 25.921751 30.43412 23.137339 FNA-T13 20.934944 25.892391 30.31687 23.168837 FNA-T14 23.826445 25.625902 31.185017 22.814573 FNA-T14 23.89024 25.501534 31.349373 22.960455 FNA-T15 21.229485 24.675568 32.35197 22.79949 FNA-T15 21.37636 25.012701 31.831976 22.992157 FNA-T16 25.229063 26.102863 32.776455 24.140661 FNA-T16 25.687212 26.261883 33.05607 24.013094 FNA-T17 19.657827 23.859627 29.69458 21.10718 FNA-T17 19.931728 24.147314 30.14789 21.13952 FNA-T18 23.434616 26.542694 32.04296 23.872118 FNA-T18 23.51714 26.584282 32.51727 23.973524 FNA-T19 22.263987 23.083506 29.259949 21.22238 FNA-T19 22.39362 23.09326 29.280416 21.326138 FNA-T2 23.141502 28.573292 33.55477 24.909723 FNA-T2 23.485144 28.964634 34.074646 24.951363 FNA-T20 21.675373 26.97268 34.023212 24.428822 FNA-T20 21.650827 27.002932 33.660378 24.438662 FNA-T21 21.501682 22.936522 29.107313 21.613956 FNA-T21 21.459675 23.002327 29.70916 21.77176 FNA-T22 23.5476 26.353445 31.454437 23.23415 FNA-T22 23.821466 26.58046 31.937336 23.269836 FNA-T23 20.700804 24.308699 30.184607 21.62827 FNA-T23 20.687664 23.913965 29.609146 21.513168 FNA-T24 24.456676 27.275145 35.223473 25.721024 FNA-T24 24.675978 27.216908 32.480167 25.836185 FNA-T25 22.337307 27.707338 35.2058 25.78641 FNA-T25 22.628887 27.837511 34.652565 26.108932 FNA-T26 23.459728 29.18395 36.588284 27.531094 FNA-T26 23.614176 28.833822 34.337036 27.636753 FNA-T27 23.90884 27.75643 33.941227 26.774282 FNA-T27 23.905787 27.815226 34.192028 26.74601 FNA-T28 22.877193 27.924435 34.261456 25.577286 FNA-T28 22.696705 27.899048 36.93079 25.635555 FNA-T29 23.184736 29.689062 35.747486 27.892754 FNA-T29 23.57018 28.800997 34.65945 28.123535 FNA-T3 23.698166 25.691387 32.20123 24.62932 FNA-T3 23.72975 25.809195 32.099625 24.723389 FNA-T30 22.996277 27.110403 33.098713 25.531672 FNA-T30 23.335133 27.591036 33.438843 25.614237 FNA-T31 22.877148 27.972603 34.231426 26.108313 FNA-T31 22.57646 27.563244 35.02869 25.890535 FNA-T32 22.991724 29.918121 36.83741 26.331404 FNA-T32 23.554337 29.858301 34.696888 26.720278 FNA-T33 22.652767 26.75156 32.684772 24.467228 FNA-T33 23.153368 26.948929 32.69105 24.734575 FNA-T34 24.82618 27.553524 40.63565 26.731283 FNA-T34 24.728811 27.462141 33.582413 26.801907 FNA-T35 22.208548 28.331123 34.13096 25.430008 FNA-T35 22.252235 27.985441 34.53764 25.61295 FNA-T36 25.183472 30.225927 33.201927 27.863577 FNA-T36 24.950567 30.059834 35.54011 28.013996 FNA-T37 23.385887 23.876055 32.544136 24.389685 FNA-T37 23.601929 23.781513 31.732666 24.442585 FNA-T38 25.105978 28.277088 44.084072 28.350552 FNA-T38 25.405413 28.242113 37.186676 28.320631 FNA-T39 21.924557 24.837963 31.8528 24.39689 FNA-T39 21.796032 24.59598 32.090496 24.547747 FNA-T4 22.715698 28.274874 35.58193 25.211798 FNA-T4 22.821077 27.842999 33.81601 25.196201 FNA-T40 23.54718 28.342707 33.322765 26.382792 FNA-T40 23.49541 28.207663 33.68603 26.462458 FNA-T41 23.564583 26.790874 33.00083 24.239904 FNA-T41 23.831728 27.141502 33.077003 24.403778 FNA-T42 19.245577 23.818342 29.376299 21.657558 FNA-T42 19.089708 23.519146 29.406467 21.68643 FNA-T43 19.30529 22.529505 28.323366 20.567038 FNA-T43 19.336924 22.543348 27.97006 20.546412 FNA-T44 20.64032 24.332214 29.681082 22.725319 FNA-T44 20.50007 24.247269 29.543419 22.663923 FNA-T45 25.197552 27.791895 34.155445 24.951199 FNA-T45 25.18148 27.723564 34.240948 24.932848 FNA-T46 19.56883 23.798355 28.558037 21.285751 FNA-T46 19.755262 23.709597 28.774336 21.349846 FNA-T47 22.90814 27.10719 31.997103 23.9283 FNA-T47 23.125473 27.094215 32.343838 24.242105 FNA-T48 22.892971 25.35467 31.83498 25.638552 FNA-T48 22.945427 25.36678 31.50254 23.506653 FNA-T49 20.707172 23.742239 29.237608 22.254862 FNA-T49 20.617254 23.52166 28.951166 22.199163 FNA-T5 23.004347 26.354876 33.14333 24.221584 FNA-T5 22.933012 26.438005 33.222958 24.293667 FNA-T50 20.168625 23.361359 29.784513 21.717112 FNA-T50 20.23227 23.493647 30.129198 21.810036 FNA-T51 22.280159 23.474936 28.952478 21.141918 FNA-T51 22.537466 23.656971 29.79213 21.390736 FNA-T52 19.521214 23.643982 29.103622 20.875029 FNA-T52 19.56719 23.674892 29.450514 21.157232 FNA-T53 23.89266 27.53248 33.90312 25.43582 FNA-T53 23.919025 27.62424 34.64586 25.45106 FNA-T54 21.781326 28.855728 34.84435 25.821611 FNA-T54 21.889166 28.484718 38.365856 25.661104 FNA-T55 22.511087 26.242882 33.210567 24.59916 FNA-T55 22.602274 26.341595 33.31462 24.636683 FNA-T56 23.152048 29.841078 38.35461 26.945574 FNA-T56 23.218822 29.634008 43.373234 26.9255 FNA-T57 24.466152 25.980993 31.783796 24.486273 FNA-T57 24.177647 25.949017 32.318287 24.434679 FNA-T58 21.24823 24.67756 32.82988 24.2605 FNA-T58 21.65543 24.903204 32.61433 24.43127 FNA-T59 22.396976 25.416971 31.779005 23.40019 FNA-T59 22.63583 25.438662 31.82377 23.452908 FNA-T6 25.859325 29.61415 34.542934 27.96887 FNA-T6 26.25842 29.986795 35.714413 28.3271 FNA-T60 22.91946 29.56167 34.83162 26.991592 FNA-T60 22.710762 29.77171 33.800293 26.837193 FNA-T61 25.105469 27.433054 34.742928 25.974476 FNA-T61 25.28259 27.345282 34.662525 25.993118 FNA-T62 24.525728 29.262197 34.50554 27.409775 FNA-T62 24.807543 29.599257 Undetermined 27.668844 FNA-T7 23.22485 25.900362 31.472517 22.983604 FNA-T7 23.366869 26.269121 32.093784 23.153976 FNA-T8 22.465874 24.141613 30.325752 22.532228 FNA-T8 22.562605 24.29681 31.401922 22.579184 FNA-T9 26.539865 28.935747 34.833427 27.334845 FNA-T9 27.228676 29.6814 34.584236 27.69754 Sample ID miR-29b-1* miR-29b-3p miR-31-5p miR-328 FNA-T1 26.552824 22.407076 21.674368 24.717823 FNA-T1 26.738533 22.68818 21.679962 24.76487 FNA-T10 29.578978 27.923645 27.209602 26.714931 FNA-T10 30.104855 27.636387 26.607618 26.492651 FNA-T11 29.801655 28.82855 29.220049 28.52914 FNA-T11 30.33799 28.94199 28.905233 28.277044 FNA-T12 31.445667 27.562014 26.282423 28.423443 FNA-T12 32.609802 27.495533 26.384924 28.415081 FNA-T13 30.620462 26.155315 25.77704 27.752846 FNA-T13 31.158028 26.07141 25.856716 27.903645 FNA-T14 30.408047 27.230663 25.737677 27.310417 FNA-T14 30.44525 27.425661 25.86754 27.442314 FNA-T15 26.69902 25.444492 29.782415 25.196224 FNA-T15 26.83123 25.58293 29.693596 25.3076 FNA-T16 30.895475 28.958227 27.21757 27.747417 FNA-T16 31.24299 29.210745 27.194315 27.5524 FNA-T17 28.573452 25.898495 24.39711 27.148203 FNA-T17 28.704588 26.101818 24.908726 27.162281 FNA-T18 30.857159 28.79546 26.306192 28.122135 FNA-T18 30.89154 28.616695 26.114096 28.193056 FNA-T19 28.924171 26.516384 24.16467 25.929075 FNA-T19 28.8763 26.657063 24.253307 25.996042 FNA-T2 30.307966 27.803764 27.817917 28.397722 FNA-T2 30.565325 27.856993 27.89706 28.562277 FNA-T20 27.164104 25.318382 31.214188 26.014467 FNA-T20 27.47511 25.2455 31.34887 25.94132 FNA-T21 29.29395 26.474457 25.319622 26.095268 FNA-T21 28.993692 26.63563 25.361935 26.132647 FNA-T22 29.889164 28.32289 26.998734 27.714632 FNA-T22 29.91072 28.499876 26.964794 27.659988 FNA-T23 28.428488 26.144009 24.765995 26.547787 FNA-T23 28.223621 25.56995 24.842922 26.389767 FNA-T24 29.733946 28.780647 29.8842 27.809406 FNA-T24 29.783478 28.941866 30.482067 27.920282 FNA-T25 29.509336 28.153896 31.00858 27.541487 FNA-T25 29.577816 28.66477 31.974932 27.854446 FNA-T26 30.795837 29.46229 30.09425 27.782421 FNA-T26 30.34819 29.380663 30.183193 28.158354 FNA-T27 30.583546 29.679585 30.389462 27.31657 FNA-T27 30.138546 29.180809 29.975212 27.275612 FNA-T28 29.447802 26.958107 29.224815 27.570503 FNA-T28 29.3097 26.708725 29.14273 27.437054 FNA-T29 28.604471 26.42835 32.183193 27.199223 FNA-T29 28.736488 26.497454 32.12903 27.127747 FNA-T3 29.660929 27.963284 30.645727 27.5603 FNA-T3 29.733301 28.240019 31.523262 27.765686 FNA-T30 28.946253 27.141096 29.745821 26.90276 FNA-T30 28.720947 27.340471 29.74179 26.82381 FNA-T31 29.354944 28.903929 31.692434 26.424232 FNA-T31 29.10675 28.486921 31.458744 26.556625 FNA-T32 30.756907 27.51954 33.502304 29.329964 FNA-T32 31.592253 27.713757 32.873417 29.71085 FNA-T33 28.117823 26.871046 31.84709 25.612028 FNA-T33 28.306261 27.167936 32.161015 25.84176 FNA-T34 28.335701 27.505013 30.548182 26.832096 FNA-T34 28.002518 27.479843 30.362991 26.855673 FNA-T35 28.900257 27.314783 29.010115 26.724215 FNA-T35 29.005304 27.63258 29.713867 26.932941 FNA-T36 30.766787 29.719513 31.582434 29.072824 FNA-T36 30.898794 30.086916 32.46275 29.225729 FNA-T37 28.643822 27.933632 30.65435 25.64595 FNA-T37 29.121542 27.585506 30.842812 25.72746 FNA-T38 32.501987 30.83824 31.608345 29.263035 FNA-T38 32.377304 30.838232 31.4355 28.796772 FNA-T39 28.469568 26.985947 28.790743 26.430431 FNA-T39 28.394993 27.003155 28.892612 26.325079 FNA-T4 29.70096 27.641838 27.997614 27.788136 FNA-T4 30.089777 27.48301 28.204514 27.51864 FNA-T40 29.535404 28.631895 32.209587 27.045666 FNA-T40 29.340818 28.945646 31.332457 26.892359 FNA-T41 28.513926 27.531015 31.700697 26.606771 FNA-T41 28.697788 27.763035 31.34682 26.520512 FNA-T42 27.17159 23.768936 24.67187 25.634274 FNA-T42 27.221664 23.780148 24.692028 25.479988 FNA-T43 27.311766 24.51567 23.661364 25.720545 FNA-T43 26.971657 24.44387 23.408943 25.807112 FNA-T44 28.614473 25.378832 24.522394 25.804615 FNA-T44 28.594675 25.456528 24.322575 25.710333 FNA-T45 31.530228 29.795317 27.698383 26.393347 FNA-T45 31.391783 29.712856 27.829576 26.452871 FNA-T46 28.797535 23.662062 23.625675 25.876642 FNA-T46 28.800667 23.96831 23.391968 25.873774 FNA-T47 30.460367 28.372406 26.189934 27.689249 FNA-T47 30.539267 28.137783 26.433525 27.787106 FNA-T48 29.636694 28.251192 25.172813 25.575579 FNA-T48 29.467516 28.492643 25.152712 25.585772 FNA-T49 28.196089 24.9778 23.246456 25.784502 FNA-T49 27.903898 24.805834 23.341095 25.622856 FNA-T5 28.81858 27.08423 28.870111 26.408035 FNA-T5 28.892872 27.171904 28.904049 26.230465 FNA-T50 27.892622 25.304169 24.839092 25.700035 FNA-T50 27.809248 25.495163 24.692587 25.635054 FNA-T51 28.804409 26.369228 24.379492 25.550999 FNA-T51 29.089012 26.880339 24.514566 25.779247 FNA-T52 27.879488 25.62345 23.779797 26.477188 FNA-T52 28.457241 25.661802 23.788904 26.412746 FNA-T53 29.229086 28.122553 30.460966 26.603947 FNA-T53 29.080864 28.127106 30.35179 26.729425 FNA-T54 30.072956 26.63474 31.593695 27.151697 FNA-T54 30.172771 26.431742 31.581427 27.194582 FNA-T55 28.083344 26.968813 30.337082 26.680065 FNA-T55 28.19728 26.960432 29.65397 26.706018 FNA-T56 30.934877 27.728243 33.710785 28.976395 FNA-T56 31.28978 28.126823 33.374626 29.97552 FNA-T57 30.093792 27.307894 28.888605 27.902843 FNA-T57 29.88062 27.230942 28.731913 27.984482 FNA-T58 27.730694 25.952473 31.333189 27.171295 FNA-T58 27.828024 26.051939 30.879128 27.379938 FNA-T59 29.22478 27.990944 25.566982 26.99639 FNA-T59 29.110918 27.79271 25.547623 27.220053 FNA-T6 30.151512 29.729553 32.15644 26.919432 FNA-T6 30.607885 29.989788 33.895775 27.135128 FNA-T60 30.099794 25.85505 32.308018 29.690987 FNA-T60 30.52286 25.911158 31.561152 29.411201 FNA-T61 31.107653 28.86514 29.17722 28.659204 FNA-T61 30.813538 29.242283 29.512753 28.473232 FNA-T62 29.332699 28.253344 31.560658 26.864761 FNA-T62 29.59081 28.642502 32.277462 27.004774 FNA-T7 29.505049 27.154976 25.201332 26.64349 FNA-T7 29.54286 27.272453 25.293428 26.27916 FNA-T8 28.886976 26.35394 24.529758 25.89689 FNA-T8 28.988264 26.36036 24.831955 26.221567 FNA-T9 31.547228 30.27583 32.58279 28.348913 FNA-T9 31.12415 30.882647 33.22385 28.463833 Sample ID miR-34a miR-375 miR-424-5p miR-551b-3p FNA-T1 21.759861 24.357325 21.689108 23.92916 FNA-T1 21.90121 24.52902 21.716686 24.213411 FNA-T10 26.714418 26.906414 27.610638 30.333134 FNA-T10 26.395859 26.84903 27.288382 29.312304 FNA-T11 27.571136 33.668278 27.786442 32.735714 FNA-T11 27.814194 33.161793 28.25139 33.91899 FNA-T12 26.743275 29.538189 25.58171 28.615417 FNA-T12 26.97743 29.535969 25.793852 28.848145 FNA-T13 26.32446 28.943882 25.823872 27.212582 FNA-T13 25.184324 28.790844 26.065561 27.57199 FNA-T14 26.87068 28.105324 26.995684 27.912191 FNA-T14 26.807198 28.220304 27.383945 27.82647 FNA-T15 25.972559 30.297363 23.469584 30.29642 FNA-T15 26.147264 30.960415 23.55051 31.237104 FNA-T16 28.341677 28.389948 26.23162 29.417755 FNA-T16 28.408524 28.559496 26.427473 29.275133 FNA-T17 23.863186 26.5023 26.409435 27.33214 FNA-T17 24.100197 26.646877 26.79651 27.65021 FNA-T18 27.613903 28.427395 28.244299 29.320124 FNA-T18 27.99891 28.254398 28.21038 29.568445 FNA-T19 25.155092 24.98625 24.376642 26.307323 FNA-T19 25.408289 24.948767 24.655384 26.65667 FNA-T2 28.846933 32.218384 27.797487 32.396782 FNA-T2 28.657774 32.25273 28.133684 33.658894 FNA-T20 26.521584 27.958426 24.983604 34.49795 FNA-T20 26.793703 27.941505 25.087746 31.87205 FNA-T21 24.22911 27.440147 25.571928 26.844156 FNA-T21 24.335741 27.470142 25.725945 27.166061 FNA-T22 26.558506 29.921537 27.155134 29.121315 FNA-T22 26.83183 29.812838 27.424238 29.771072 FNA-T23 24.26695 29.322336 26.358822 27.758314 FNA-T23 23.75239 29.62862 26.281637 27.847853 FNA-T24 28.781298 33.359737 27.35114 31.791058 FNA-T24 28.783527 32.31928 27.85144 32.25515 FNA-T25 27.217218 34.218094 27.433104 39.353657 FNA-T25 27.640055 35.411415 28.298134 33.99329 FNA-T26 28.286097 35.812702 27.71359 34.886494 FNA-T26 28.192442 34.335247 28.346489 33.58086 FNA-T27 27.707132 34.855465 29.58477 35.19459 FNA-T27 27.739868 35.77197 29.687668 35.304783 FNA-T28 28.52387 34.582108 26.444414 34.218353 FNA-T28 28.180721 33.574974 26.334066 33.263306 FNA-T29 25.505648 34.221226 25.376543 35.334885 FNA-T29 25.576519 33.386536 25.414387 34.437332 FNA-T3 26.475283 27.948328 25.575031 33.1651 FNA-T3 26.72403 27.878012 25.800873 33.890945 FNA-T30 25.80545 34.008995 25.832836 34.11272 FNA-T30 26.115345 34.093388 26.072142 33.140255 FNA-T31 27.499578 32.945213 27.39106 32.463623 FNA-T31 27.16642 34.386936 26.962072 33.497566 FNA-T32 31.421667 33.854218 25.922308 32.580975 FNA-T32 32.63763 35.10524 26.213865 34.909473 FNA-T33 26.306517 37.614838 22.88349 33.628967 FNA-T33 26.454823 35.20879 23.211344 34.75065 FNA-T34 26.449413 33.447548 26.982445 32.989803 FNA-T34 26.341072 33.379044 26.879694 35.20106 FNA-T35 26.968714 29.135952 25.497559 33.308086 FNA-T35 27.189608 29.120487 25.715252 32.951935 FNA-T36 28.91105 34.953197 27.69415 34.817013 FNA-T36 28.894653 33.975353 27.690119 33.352234 FNA-T37 26.910515 35.39039 26.13929 33.478268 FNA-T37 26.862045 41.395145 26.40512 32.866364 FNA-T38 28.332905 36.336166 27.403008 33.263515 FNA-T38 28.450504 36.306988 27.721601 37.213985 FNA-T39 26.509357 31.333836 25.737087 32.973557 FNA-T39 26.499653 31.396465 25.934643 33.704407 FNA-T4 28.71147 31.783518 27.354052 31.642044 FNA-T4 28.673788 31.917233 27.443644 32.118744 FNA-T40 28.10988 35.244644 26.687002 31.886219 FNA-T40 27.704485 34.488426 26.902958 33.005867 FNA-T41 28.116488 30.461643 26.472574 33.29255 FNA-T41 28.713839 31.137833 26.642555 32.95098 FNA-T42 24.331818 26.979107 23.70171 26.858057 FNA-T42 24.23564 26.843723 23.762442 26.73503 FNA-T43 23.246593 25.80915 23.447712 25.407848 FNA-T43 23.482557 25.90109 23.405668 25.314327 FNA-T44 24.191206 24.123878 22.833368 26.322565 FNA-T44 24.20323 24.072432 22.768677 26.346481 FNA-T45 28.792751 29.191832 27.903502 30.956787 FNA-T45 28.881836 29.281704 28.120775 30.604996 FNA-T46 24.505272 26.103832 24.481792 25.292429 FNA-T46 24.524801 26.198767 24.738825 25.27952 FNA-T47 25.661707 27.970852 25.671757 28.870934 FNA-T47 25.525518 28.165735 25.975157 29.276144 FNA-T48 25.584394 25.316916 26.86571 28.38578 FNA-T48 25.43255 25.348103 27.139637 28.41595 FNA-T49 24.199627 25.421167 24.435448 26.12788 FNA-T49 24.128614 25.343431 24.296907 26.10545 FNA-T5 28.22904 28.223204 25.668484 32.015877 FNA-T5 28.130407 28.367552 25.708902 31.857765 FNA-T50 24.635742 26.419092 23.418978 27.62377 FNA-T50 24.799103 26.599754 23.560799 27.477293 FNA-T51 24.850182 25.827854 25.093607 27.454805 FNA-T51 25.178524 26.155672 25.549541 27.436525 FNA-T52 23.40972 27.213345 23.948849 26.530197 FNA-T52 23.415026 27.178568 24.14129 26.547876 FNA-T53 29.006569 31.934603 26.50384 33.893867 FNA-T53 30.00482 32.228584 26.785177 33.594067 FNA-T54 30.230719 35.55649 24.54654 33.81531 FNA-T54 30.348034 33.777855 24.50558 33.37074 FNA-T55 27.150486 30.397959 26.60232 32.5844 FNA-T55 27.450245 30.535732 26.84302 33.873325 FNA-T56 30.826586 33.905197 25.787544 35.205944 FNA-T56 31.207478 34.584137 26.272888 35.307472 FNA-T57 27.335266 25.708355 24.945887 29.157518 FNA-T57 27.388218 26.221941 24.756659 28.935549 FNA-T58 29.32769 31.663275 24.78945 32.03856 FNA-T58 29.572084 31.539835 25.112747 31.817013 FNA-T59 26.361597 26.910456 25.969242 28.525698 FNA-T59 26.52823 26.91924 26.02117 28.516512 FNA-T6 29.114359 35.416687 27.748613 Undetermined FNA-T6 29.507107 37.737366 27.9832 38.977604 FNA-T60 29.171234 32.740345 24.909168 34.16094 FNA-T60 29.369196 33.4151 24.969099 33.008026 FNA-T61 27.463772 30.406023 27.430864 36.95841 FNA-T61 27.75444 30.957478 27.97967 33.324726 FNA-T62 27.915558 27.626045 26.68034 28.60977 FNA-T62 28.15422 27.920708 27.069723 28.961477 FNA-T7 27.875864 28.565523 26.22175 29.542273 FNA-T7 27.975122 28.598747 26.411266 29.828125 FNA-T8 25.715467 28.33554 24.43361 30.01527 FNA-T8 25.809011 28.592302 25.037632 30.422173 FNA-T9 30.436687 32.909435 28.329449 Undetermined FNA-T9 31.15085 35.34046 28.869225 33.567963 Sample ID miR-7-5p miR-96-5p FNA-T1 24.46035 26.107105 FNA-T1 24.46492 26.13061 FNA-T10 27.78626 30.723984 FNA-T10 28.47452 29.596931 FNA-T11 30.17391 30.918604 FNA-T11 29.90885 30.655432 FNA-T12 33.76864 32.239414 FNA-T12 32.76183 32.28395 FNA-T13 31.15464 31.583239 FNA-T13 30.68807 31.939806 FNA-T14 32.40135 32.337006 FNA-T14 32.8548 32.111927 FNA-T15 25.17525 28.431435 FNA-T15 25.40695 27.549498 FNA-T16 31.49821 31.727325 FNA-T16 31.56099 31.483181 FNA-T17 30.2633 29.865303 FNA-T17 31.10866 29.800121 FNA-T18 32.07932 34.49733 FNA-T18 31.75947 33.630657 FNA-T19 31.04584 32.60601 FNA-T19 31.57937 33.249607 FNA-T2 30.74412 30.705088 FNA-T2 30.01509 31.319689 FNA-T20 23.31374 27.27577 FNA-T20 23.23589 27.185717 FNA-T21 31.33283 29.375444 FNA-T21 31.54454 29.20065 FNA-T22 30.41792 29.98111 FNA-T22 30.24154 30.21693 FNA-T23 28.48276 28.855429 FNA-T23 28.40838 28.46479 FNA-T24 28.24032 30.539133 FNA-T24 28.43015 30.84059 FNA-T25 25.88101 29.10208 FNA-T25 26.35999 29.604494 FNA-T26 30.37015 31.170195 FNA-T26 30.67165 30.97432 FNA-T27 28.9647 32.97908 FNA-T27 28.80167 32.51327 FNA-T28 28.5642 29.83185 FNA-T28 28.76439 29.795675 FNA-T29 24.70477 28.38451 FNA-T29 24.92562 28.464401 FNA-T3 28.43561 29.757824 FNA-T3 27.89716 30.203068 FNA-T30 27.13216 27.968243 FNA-T30 27.25848 28.32718 FNA-T31 25.50765 32.13602 FNA-T31 25.57574 31.709713 FNA-T32 26.87805 29.005896 FNA-T32 27.01653 29.350685 FNA-T33 23.21308 29.309095 FNA-T33 23.43962 29.411545 FNA-T34 28.19318 29.412329 FNA-T34 28.30631 29.23639 FNA-T35 24.64907 28.87817 FNA-T35 25.09017 29.19014 FNA-T36 26.9485 31.188734 FNA-T36 27.21083 30.639658 FNA-T37 28.58959 29.905659 FNA-T37 28.56261 29.908806 FNA-T38 32.7213 34.21291 FNA-T38 32.79255 32.709476 FNA-T39 27.66424 27.81202 FNA-T39 27.0982 28.013802 FNA-T4 29.55808 29.872852 FNA-T4 29.50446 29.952682 FNA-T40 25.90843 29.320099 FNA-T40 25.76527 29.29864 FNA-T41 28.73733 27.673727 FNA-T41 28.13154 28.199219 FNA-T42 25.21124 26.567322 FNA-T42 24.37088 26.479298 FNA-T43 26.84822 26.861986 FNA-T43 26.34531 26.84644 FNA-T44 27.92295 29.3795 FNA-T44 27.80024 29.724712 FNA-T45 30.70461 32.183765 FNA-T45 31.41038 31.81356 FNA-T46 26.84471 27.751984 FNA-T46 27.36969 27.85507 FNA-T47 30.30388 29.571192 FNA-T47 30.89902 30.149002 FNA-T48 33.7549 32.988167 FNA-T48 33.52822 33.74298 FNA-T49 26.93898 28.287607 FNA-T49 26.73706 28.23724 FNA-T5 27.4728 28.540136 FNA-T5 27.54598 28.507719 FNA-T50 24.57541 26.98736 FNA-T50 24.5551 27.314873 FNA-T51 29.96059 31.82041 FNA-T51 30.48503 32.517166 FNA-T52 28.43395 27.556486 FNA-T52 28.2359 27.767237 FNA-T53 25.96144 29.29252 FNA-T53 25.79281 29.348373 FNA-T54 27.14429 28.32788 FNA-T54 27.42552 27.934515 FNA-T55 26.18757 28.257067 FNA-T55 26.38634 28.369804 FNA-T56 27.93556 30.851402 FNA-T56 28.46733 30.99064 FNA-T57 28.94717 30.359634 FNA-T57 28.76204 29.979872 FNA-T58 26.3276 28.790974 FNA-T58 26.76476 29.1504 FNA-T59 29.35478 30.772585 FNA-T59 29.91906 30.500744 FNA-T6 27.30776 31.164837 FNA-T6 27.9615 31.79102 FNA-T60 27.92587 27.634392 FNA-T60 27.93238 27.844763 FNA-T61 25.7991 30.445461 FNA-T61 26.34176 30.246597 FNA-T62 26.68377 29.931646 FNA-T62 26.64297 30.5349 FNA-T7 29.85429 30.101599 FNA-T7 29.80737 30.094799 FNA-T8 29.26844 28.872662 FNA-T8 29.68719 29.60882 FNA-T9 30.77081 32.787815 FNA-T9 31.20988 32.57085

FNA Classifier Results

A total of 62 FNAs were also analyzed. RT-qPCR results for each replicate of the 26 miRNA assays are summarized in Table W2. The intercept (w₀) and weight coefficients (w_(i) for i>0) for the constrained logistic regression classifiers trained as described in section entitled “Constrained logistic regression method for constructing miRNA-based classifiers” above are indicated in Table D1. The leave-one-out-cross-validation (LOOCV) estimated accuracies and AUCs of the models were: (1) 5-miRNA model: accuracy 90% (95% CI: 80%-96%), AUC 0.93; (2) 10-miRNA model: accuracy 94% (95% CI: 84%-98%), AUC 0.96. For both the 5- and 10-miRNA models, model sensitivity with regard to BRAF-mutation negative malignant samples was estimated by LOOCV at 79% (95% CI: 49%-95%), while sensitivity for BRAF-mutation positive malignant samples was estimated at 100% (95% CI: 85%-100%). The specificity of (1) the 5-miRNA model was estimated at 88% (95% CI: 70%-98%), while the specificity of (2) the 10-miRNA model was estimated at 96% (95% CI: 80%-100%). The LOOCV classification scores produced by these models are shown in FIG. 7 and FIG. 8, respectively.

TABLE D1 Predictor 5 miRNA Model 10 miRNA Model (Intercept) 4.99 3.54 miR-375 −0.42 −0.43 miR-221* −0.35 miR-222 −0.09 −0.33 miR-424 −0.27 miR-551b −0.27 −0.18 miR-146b-3p −0.45 −0.17 miR-31 −0.08 miR-139-5p 0.42 miR-7 0.51 miR-141 1.23 0.88

The miRNA predictors used by the classifiers break down into two categories according to the sign of their coefficients in the models: those miRs which are substantially overexpressed in malignant samples as compared to benign samples tend to receive strongly negative model coefficients, while those miRs which exhibit similar or lower expression levels in malignant samples as compared with benign enter the models with positive coefficients. The most negatively-weighted miRNA predictor in the 5-miRNA model was found to be miR-146b-3p, with miR-375 a close second (Table D1); for the 10-miRNA model, miR-375 had the largest magnitude coefficient among the negatively weighted miRNAs, with miR-221* coming second. For both the 5- and 10-miRNA models, miR-141 (which showed little difference in expression levels between malignant and benign samples) was assigned the largest positive coefficient.

TABLE X Patient information and histopathological data for the second set (Set2) of thyroid FFPE samples. AJCC/ AJCC/ UICC Sample Pathology- Excision UICC Stage miRInform ® ID (Abbr) Histopathology Age Sex Ethnicity Year Stage Group Thyroid AF117 PTC Papillary 38 F AA 1995 T2N1MX I BRAF V600E carcinoma AE118 FTC Follicular 47 F C 1995 T2NXMX II PAX8/PPARg carcinoma AF119 MNG Goiter, 44 F C 1996 T1bN1MX III Neg multinodular AF120 FTC Follicular 46 F C 1996 T3NXMX III Neg carcinoma AF121 FA Follicular adenoma 47 F C 1996 T2NXMX II Neg AF122 Hash Follicular Adenoma 52 F C 2006 T2NXM0 II Neg AF123 FA Follicular Adenoma 41 F C 2007 T3NXM0 I Neg AF124 NH Nodular 54 M C 2009 N/A N/A Neg Hyperplasia AF125 PTC Papillary 24 M C 2007 T3N1MX I BRAF V600E Carcinoma AF126 PTC Papillary 45 F C 2008 T3NXM0 III Neg Carcinoma AF127 NH Nodular 88 F C 2009 N/A N/A Neg Hyperplasia AF128 FvPTC Papillary 38 F C 2009 T2NXMX I Neg Carcinoma, Follicular Variant AF129 FTC Follicular 52 F C 2010 T2NXM0 II Neg carcinoma AF130 PTC Papillary 49 F C 2009 T3N0M0 III Neg carcinoma AF131 PTC Papillary 40 F C 2009 T2N0M0 I Neg carcinoma AF132 FTC Follicular 79 F C 2009 T1N1M0 III Neg Carcinoma AF133 FA Hyperplasia 70 M C 2009 N/A N/A Neg AF134 PTC Papillary 53 F C 2009 T2N0M0 II BRAF V600E carcinoma AF135 MNG Goiter, 73 M C 2009 N/A N/A Neg multinodular AF136 PTC Papillary 77 M AP 2011 T3NXM0 III Neg carcinoma AF137 PTC Papillary 24 M AP 2011 T3NXM0 I BRAF V600E carcinoma AF138 PTC Papillary 19 F AP 2011 T1bNXM0 I BRAF V600E carcinoma AF139 PTC Papillary 67 F AP 2011 T3NXM0 III BRAE V600E carcinoma AF140 NH Nodular 68 F C 2008 T3NXM0 III Neg Hyperplasia AF141 PTC Papillary 58 F C 1994 T3NXMX III BRAF V600E carcinoma AF142 FA Follicular adenoma 36 M C 1994 T2NXMX I Neg AF143 OFA Hurthle cell 52 M C 1994 T3NXMX III Neg adenoma AF144 FvPTC Papillary 29 F C 1994 T3NXMX I BRAF V600E carcinoma, follicular variant AF145 FA Follicular adenoma 38 F C 1994 N/A N/A Neg AF146 FTC Follicular 67 M C 1993 T3NXMX III HRAS Q61R carcinoma AF147 PTC Papillary 54 F C 2008 T2NXM0 II Neg Carcinoma AF148 NH nodular 66 M C 2004 N/A N/A Neg hyperplasia AF149 NH Nodular 45 M C 2004 N/A N/A Neg Hyperplasia AF150 NH Nodular 46 F C 2004 N/A N/A Neg Hyperplasia AF151 FTC Follicular 61 F C 1994 TXNXMX Neg carcinoma AF152 FA Follicular adenoma 65 F C 1995 N/A N/A Neg AF153 FTC Follicular 46 F C 1997 T2NXMX PAX/PPARG carcinoma AF154 Hash Hashimoto's 48 F C 1995 N/A N/A Neg thyroiditis AF156 NH Nodular 29 F C 2004 T1N0M0 I Neg Hyperplasia AF157 FA Follicular Adenoma 47 M C 2006 T2NXMX II Neg AF158 Hash Hashimoto's 81 M C 1995 T2N0MX II Neg thyroiditis AF159 Hash Hashimoto's 45 F AP 1995 T1aN0MX I Neg thyroiditis AF160 PTC Papillary 37 F C 1996 T2NXMX I BRAF V600 carcinoma AF161 FA Follicular adenoma 31 F C 1996 T2NXMX I Neg AF162 NH Nodular N/A N/A N/A N/A N/A N/A Neg Hyperplasia AF163 FTC Follicular 75 F BAA 1994 T3NXMX III NRAS Q61K carcinoma AF164 FA Follicular adenoma 44 M C 1994 N/A N/A Neg AF165 FTC Follicular 60 F C 1995 T4aNXMX IVA Neg carcinoma AF166 OFA Hurthle cell 42 F C 1995 N/A N/A Neg adenoma AF167 MNG Goiter, 46 F C 1995 N/A N/A Neg multinodular AF168 MNG Goiter, 36 F C 1995 T2NXMX I Neg multinodular AF169 Hash Hashimoto's 36 F C 1995 N/A N/A Neg thyroiditis AF170 FvPTC Papillary 35 M C 1997 T2NXMX Neg carcinoma, follicular variant AF171 FvPTC Papillary 60 F C 1997 T4NXMX HRAS Q61L carcinoma, follicular variant AF172 PTC Papillary 52 F C 2005 T3N1aM0 III Neg Carcinoma AF173 FvPTC Papillary 52 F C 2002 T2NXM0 II Neg Carcinoma, Follicular Variant AF174 PTC Papillary N/A N/A N/A N/A N/A N/A BRAF V600E Carcinoma AF176 PTC Papillary 24 M C 1997 T3N1MX I Neg carcinoma AF176 FvPTC Papillary 40 F C 1996 T2NXMX I BRAF V600E carcinoma, follicular variant AF177 FvPTC Papillary 53 F C 1997 N/A N/A Neg carcinoma, follicular variant AF178 FvPTC Papillary 63 M C 2001 N/A N/A BRAF V600E Carcinoma, Follicular Variant AF179 PTC Papillary 52 F C 2006 T1NXMX I Neg Carcinoma AF180 PTC Papillary 46 F C 2006 T1NXMX I Neg Adenocarcinoma AF181 PTC Papillary 62 F C 2006 T3NXM0 III BRAF V600E Carcinoma AF183 Hash Hashimoto's 73 F C 1996 T1aN0MX I neg thyroiditis Anaplastic cancer (ATC); Follicular Adenoma (FA); oncocytic FA (OFA); Follicular carcinoma (FTC); Papillary carcinoma (PTC); Follicular variant of PTC (FvPTC), Hashimoto's thyroiditis (HASH); multinodular goiter (MNG); hyperplastic nodules (HN); Age at Excision (Age); Male (M); Female (F); African-American (AA); Black/African-American (BAA); Caucasian (C); Asian/Pacific (AP)

TABLE Y Mean STDEV Sample Name Mean Benign STDEV Benign Malignant Malignant hsa-miR-150_st 10.38952 1.986007 10.6115756 1.75562767 hsa-let-7a-2-star_st 4.357289 0.514889 4.73780993 0.53708965 hsa-let-7a-star_st 3.46136 0.5399 3.6352817 0.48318111 hsa-miR-513b_st 10.85016 0.938455 9.90799044 1.85099487 hsa-let-7b-star_st 7.23489 0.583163 7.53839807 0.84976115 hsa-miR-593-star_st 9.472863 1.171043 8.62865919 1.48126588 hsa-let-7c-star_st 5.1015 0.479473 5.26218298 0.57284025 hsa-miR-516a-5p_st 7.094672 0.968459 6.3859007 1.08219292 hsa-miR-142-5p_st 5.406472 1.857546 6.27084979 1.47691603 hsa-miR-650_st 11.0446 0.637241 10.3854437 0.97124484 hsa-miR-513c_st 8.08382 0.957614 7.31029183 1.34694414 hsa-miR-761_st 8.196539 0.947349 7.76052319 1.01121665 hsa-let-7f-1-star_st 5.268617 0.542365 5.21174304 0.61755578 hsa-miR-513a-5p_st 12.32717 0.803544 11.6163995 1.55772595 hsa-miR-654-5p_st 11.43621 0.805136 10.5616472 0.97997343 hsa-let-7g-star_st 4.799798 0.37421 4.98768358 0.47524897 hsa-miR-3163_st 8.831189 0.723743 8.2157038 0.85874696 hsa-let-7i-star_st 5.959516 0.674877 6.93456687 0.98886368 hsa-miR-3165_st 7.767602 0.923176 7.05148597 1.20984278 hsa-miR-3194_st 11.38148 0.707084 10.6703154 0.90438404 hsa-miR-100-star_st 3.285287 0.574897 3.43309333 0.62473728 hsa-miR-4251_st 6.819539 0.892629 6.26363215 1.03574394 hsa-miR-101-star_st 3.906051 0.436347 4.3024388 0.50828268 hsa-miR-922_st 6.359004 0.788619 5.97533821 0.95110788 hsa-miR-103-2-star_st 5.337153 0.697506 5.74616724 0.7137798 hsa-miR-155_st 9.205806 1.316447 9.86291669 1.24628916 hsa-miR-105_st 3.953412 0.476763 3.75434474 0.46741637 hsa-miR-127-5p_st 7.610083 0.913334 7.12920119 1.12004162 hsa-miR-1286_st 9.388755 0.961808 9.02744344 0.93476374 hsa-miR-106a-star_st 3.51646 0.564608 3.62554268 0.51885134 hsa-miR-890_st 6.438965 0.98878 6.26391341 0.98663664 hsa-miR-3126-5p_st 12.64894 0.591335 11.7688999 1.2446833 hsa-miR-489_st 9.953939 0.730284 9.25821725 1.4084366 hsa-miR-10a_st 8.055236 1.615627 8.94837628 1.36028815 hsa-miR-10a-star_st 5.059565 1.029601 5.09416832 0.71190049 hsa-miR-10b_st 8.996288 1.603747 10.2327628 1.31631617 hsa-miR-10b-star_st 4.993942 0.695308 5.23391564 0.63009526 hsa-miR-1178_st 4.687587 0.500872 4.45768531 0.58350995 hsa-miR-1179_st 3.37391 0.433916 3.55336092 0.56249274 hsa-miR-1180_st 9.547859 0.541327 9.15211729 0.45721059 hsa-miR-1181_st 9.434006 0.707851 9.14468304 0.79915025 hsa-miR-3138_st 11.2951 0.547575 10.5022507 0.98344812 hsa-miR-220c_st 6.650857 0.82295 6.18928893 0.74203974 hsa-miR-510_st 9.297377 0.578111 8.53620233 0.96395687 hsa-miR-1185_st 3.016118 0.63058 2.95615293 0.55549584 hsa-miR-1193_st 10.6574 0.43507 10.3641434 0.41480404 hsa-miR-1197_st 3.724772 0.50822 3.73017576 0.47494647 hsa-miR-1200_st 4.47716 0.433778 4.5156683 0.45777405 hsa-miR-1201_st 8.333221 1.38038 8.86932578 1.24780914 hsa-miR-1202_st 13.77383 0.370809 13.1939211 0.53330107 hsa-miR-30c-1-star_st 10.55832 0.789909 9.87482854 1.25076796 hsa-miR-1204_st 5.447949 0.591326 5.21394368 0.64684982 hsa-miR-1205_st 4.455803 0.510428 4.29667029 0.43260039 hsa-miR-1206_st 3.136778 0.559368 3.16466435 0.52669384 hsa-miR-1207-3p_st 4.426257 0.509645 4.31709345 0.41886113 hsa-miR-1207-5p_st 14.77373 0.41229 14.3125136 0.44885445 hsa-miR-1208_st 10.91148 0.638299 10.1011842 0.82716953 hsa-miR-622_st 9.2618 0.609418 8.72085232 1.03477025 hsa-miR-1224-3p_st 5.545164 0.580603 5.53508927 0.51739318 hsa-miR-2116_st 6.438526 0.857813 5.9242753 0.87314661 hsa-miR-1225-3p_st 6.535976 0.686195 6.36329234 0.60803155 hsa-miR-1225-5p_st 14.59143 0.4084 14.0737575 0.5109831 hsa-miR-1226_st 5.944648 0.659491 5.75163868 0.48904257 hsa-miR-30b-star_st 9.3287 0.63229 8.66928794 0.78001447 hsa-miR-1227_st 4.590626 0.691355 4.6803536 0.60477427 hsa-miR-1295_st 6.878274 0.600932 6.35636625 0.68770121 hsa-miR-1228-star_st 15.61034 0.573307 15.3085406 0.5665271 hsa-miR-20b_st 8.194981 1.086889 9.64529683 1.13784137 hsa-miR-122-star_st 3.368453 0.474343 3.40177665 0.47901734 hsa-miR-1231_st 14.53925 0.488525 14.0000351 0.51755774 hsa-miR-1233_st 6.445083 0.633746 6.07615059 0.57351771 hsa-miR-524-5p_st 5.412551 0.788718 5.21779251 0.64776897 hsa-miR-1236_st 6.135532 0.73513 6.10499204 0.67831659 hsa-miR-873_st 5.434142 0.677063 5.11675727 0.70875546 hsa-miR-1238_st 7.621242 0.721776 7.37548619 0.6861198 hsa-miR-124_st 9.061091 0.526261 8.91111599 0.61616007 hsa-miR-1243_st 4.350738 0.443074 4.34341673 0.5047149 hsa-miR-1244_st 8.491907 0.799179 8.61243674 1.07054454 hsa-miR-1245_st 4.318502 0.438666 4.24588943 0.47547173 hsa-miR-3122_st 12.11072 0.396089 11.2726089 0.86619843 hsa-miR-134_st 10.21842 0.578755 9.39273751 0.89478316 hsa-miR-1248_st 10.16793 1.127361 10.1172362 1.60343786 hsa-miR-146a_st 8.887683 1.481866 10.5913748 1.72802847 hsa-miR-124-star_st 5.615336 0.508358 5.37160278 0.40689305 hsa-miR-1250_st 8.384996 0.596273 7.77720251 0.70818305 hsa-miR-764_st 5.749416 0.751104 5.43109307 0.66064111 hsa-miR-1252_st 3.215106 0.541593 3.42039276 0.50459537 hsa-miR-223_st 9.019365 1.270088 9.99254043 1.56807286 hsa-miR-34c-3p_st 8.568783 0.777162 7.91659629 0.96040607 hsa-miR-1255a_st 5.237402 0.778395 5.36918925 0.71236113 hsa-miR-1255b_st 7.983933 0.575313 7.73166901 1.26068293 hsa-miR-1256_st 3.955908 0.462784 4.06324904 0.52738418 hsa-miR-1257_st 5.22604 0.586825 5.24551787 0.49267956 hsa-miR-199b-5p_st 6.969523 2.030831 6.75422466 2.30813172 hsa-miR-1259_st 3.299872 0.535781 3.48222159 0.5039441 hsa-miR-492_st 9.328439 0.62203 8.68643223 0.88025514 hsa-miR-3132_st 9.699389 0.581574 9.11466067 0.98875953 hsa-miR-516b_st 7.279491 0.743569 6.7175821 0.91554739 hsa-miR-4294_st 9.088439 0.496404 8.38722481 0.95167841 hsa-miR-125b-2-star_st 10.12684 0.924505 9.86394277 0.82445524 hsa-miR-126_st 13.49144 1.086588 13.9975867 0.97182874 hsa-miR-198_st 12.56028 0.476438 11.8599303 1.01121456 hsa-miR-3191_st 11.9685 0.77925 11.4910121 1.07972177 hsa-miR-1261_st 7.937375 0.872943 7.42052755 1.10708599 hsa-miR-1262_st 4.476336 0.662835 4.36652798 0.52679639 hsa-miR-1263_st 4.433542 0.40919 4.54708684 0.43130432 hsa-miR-1264_st 3.614714 0.385273 3.67854575 0.55524343 hsa-miR-1265_st 5.27597 0.383067 5.44978149 0.5585284 hsa-miR-2114-star_st 7.402733 0.88373 6.89938422 1.07963391 hsa-miR-1267_st 4.43422 0.444069 4.17635775 0.38903668 hsa-miR-1268_st 14.52499 0.516985 14.0374836 0.49493537 hsa-miR-1269_st 6.005642 0.619387 5.6353091 0.58884571 hsa-miR-509-5p_st 6.534175 0.72875 6.07449563 0.80518836 hsa-miR-1270_st 6.653462 0.478535 6.38125403 0.62625484 hsa-miR-1271_st 7.771615 0.646477 7.49872364 0.77209925 hsa-miR-4303_st 7.21271 0.653178 6.71359698 0.72842596 hsa-miR-1273_st 10.14442 0.526005 9.65652443 0.83281863 hsa-miR-583_st 7.365099 0.868159 7.12713789 1.14313295 hsa-miR-1273d_st 10.74788 0.48916 10.4845754 0.55836515 hsa-miR-127-3p_st 6.076071 0.846256 6.5419768 1.49727579 hsa-miR-522-star_st 6.556959 0.734561 5.98997852 0.60266289 hsa-miR-214-star_st 5.544811 0.861459 5.70451843 1.13591376 hsa-miR-184_st 8.438343 0.850087 7.88354075 0.92726689 hsa-miR-614_st 6.463475 0.859388 6.14691367 0.97929551 hsa-miR-526b_st 5.889509 0.743883 5.54332474 0.67953542 hsa-miR-1277_st 3.313252 0.613061 3.53021114 0.54586911 hsa-miR-1278_st 3.92404 0.418186 4.1532405 0.57555697 hsa-miR-1279_st 3.547495 0.548873 3.66349591 0.51664879 hsa-miR-409-3p_st 6.657151 0.81253 6.5378946 1.00805052 hsa-miR-199a-5p_st 9.697437 1.328057 9.96347873 1.68904486 hsa-miR-1281_st 10.15523 0.660057 9.77871988 0.60212618 hsa-miR-1282_st 4.143756 0.587692 4.06748009 0.60470114 hsa-miR-33b-star_st 7.608316 0.469182 7.07200218 0.6468988 hsa-miR-1284_st 5.202345 0.687226 5.15836567 0.45722521 hsa-miR-1253_st 5.143236 0.680207 4.99361874 0.61031078 hsa-miR-584_st 8.04233 0.610655 7.44698406 0.78758502 hsa-miR-1287_st 6.330628 0.567947 6.32517179 0.54468857 hsa-miR-15a_st 9.400582 1.252219 11.2912451 1.16714496 hsa-miR-1289_st 4.784908 0.507687 4.70509184 0.48657725 hsa-miR-1290_st 10.6555 0.508518 10.688131 0.79078482 hsa-miR-2117_st 4.350308 0.547362 4.04519566 0.56664069 hsa-miR-1292_st 13.0471 0.45811 12.435359 0.63904949 hsa-miR-1293_st 7.765086 0.515708 7.25481822 0.58041738 hsa-miR-129-3p_st 3.9061 0.56408 4.28944547 1.08009037 hsa-miR-520d-5p_st 7.202907 0.777321 6.78993349 0.76731494 hsa-miR-526a_st 6.923736 0.717346 6.62565189 0.7583461 hsa-miR-129-5p_st 11.93347 0.497136 11.2705039 0.72035409 hsa-miR-1254_st 12.26813 0.629792 11.56637 0.83408274 hsa-miR-1297_st 3.238424 0.452585 3.22577271 0.60188484 hsa-miR-1298_st 4.943392 0.710928 4.99876047 0.7316201 hsa-miR-1299_st 5.782281 0.6536 5.63159734 0.98084374 hsa-miR-129-star_st 4.372468 0.568782 4.50913149 0.54666149 hsa-miR-1301_st 8.801853 0.445676 8.50042486 0.45196955 hsa-miR-19b_st 9.19229 1.308257 10.5795935 1.2774744 hsa-miR-1303_st 10.67638 0.533078 10.2721073 0.68711508 hsa-miR-1304_st 7.661559 0.74942 7.34902996 0.93193949 hsa-miR-1305_st 4.248962 0.580281 4.1858747 0.47206909 hsa-miR-550_st 12.18404 0.629339 11.6879493 0.8199054 hsa-miR-1307_st 14.08975 0.586589 13.5355464 0.57386276 hsa-miR-1308_st 14.94022 0.605185 15.2503915 0.55230295 hsa-miR-4291_st 7.029601 0.991374 7.7994051 0.94926531 hsa-miR-130a-star_st 3.978493 0.488964 3.98471736 0.46117242 hsa-miR-130b_st 8.085583 0.751431 8.50271914 0.81869108 hsa-miR-130b-star_st 4.852718 0.663151 5.12802279 0.74686133 hsa-miR-921_st 12.04582 0.530387 11.37426 0.82357838 hsa-miR-520a-5p_st 5.059042 0.608316 4.79466106 0.53072223 hsa-miR-711_st 12.27524 0.589288 11.7096369 0.78223308 hsa-miR-1323_st 8.829832 0.603626 8.18944317 0.71589806 hsa-miR-1324_st 3.571799 0.533497 3.70749581 0.60082365 hsa-miR-490-3p_st 6.38212 0.659382 5.94635026 0.6740777 hsa-miR-718_st 9.107095 0.612011 8.50757811 0.91841826 hsa-miR-133b_st 5.690387 1.252192 6.10093928 2.20827788 hsa-miR-431-star_st 6.962108 0.596349 6.27230418 0.69489517 hsa-miR-552_st 6.013338 0.719863 5.56340615 0.6974508 hsa-miR-28-3p_st 7.126921 1.096338 7.92138802 1.10127288 hsa-miR-4265_st 8.251232 0.647082 7.54002814 0.72307606 hsa-miR-643_st 4.276702 0.678278 4.01396145 0.49684553 hsa-miR-136_st 3.090885 0.640674 3.23295897 0.58806563 hsa-miR-136-star_st 3.280648 0.527551 3.38422196 0.55529244 hsa-miR-137_st 3.480772 0.387736 3.53007945 0.47842398 hsa-miR-138_st 10.59837 1.100913 10.3596559 1.29577727 hsa-miR-138-1-star_st 8.597092 0.518887 8.15914785 0.72851942 hsa-miR-138-2-star_st 5.306019 0.416304 5.39000029 0.540153 hsa-miR-139-3p_st 8.310386 0.662357 7.93959998 0.65140966 hsa-miR-139-5p_st 7.9866 1.235272 7.89525401 1.27891605 hsa-miR-140-3p_st 10.74996 0.551884 11.0888308 0.66934848 hsa-miR-140-5p_st 5.713316 1.0075 6.6856171 1.21515569 hsa-miR-381_st 6.47366 0.789362 6.21027434 0.92935905 hsa-miR-141-star_st 3.756301 0.425378 4.29696272 0.84231106 hsa-miR-17-star_st 6.15162 0.608628 7.10145886 0.91817935 hsa-miR-4300_st 8.291227 0.742608 7.79887903 0.92079282 hsa-miR-143_st 11.98463 1.07468 12.5033545 1.12331495 hsa-miR-143-star_st 6.366789 0.764475 6.93224596 0.94194012 hsa-miR-144_st 3.478006 0.469105 3.44911308 0.57199178 hsa-miR-3198_st 10.25799 0.399259 9.6473457 0.70473787 hsa-miR-145_st 13.02634 1.036508 13.2760415 1.16455684 hsa-miR-145-star_st 5.576553 1.195807 6.09930048 1.18613508 hsa-miR-1468_st 6.041576 0.706105 5.96189889 0.72289541 hsa-miR-1469_st 15.85414 0.655596 15.7558719 0.61472764 hsa-miR-1973_st 14.84394 0.914458 14.2257825 1.01519972 hsa-miR-3154_st 11.841 0.394263 11.2308784 0.63736609 hsa-miR-148a-star_st 5.335065 0.856261 5.48777864 0.74163478 hsa-miR-92a-1-star_st 8.43774 0.627976 7.8116457 0.67334339 hsa-miR-147_st 4.369728 0.460573 4.22191724 0.45406229 hsa-miR-194-star_st 9.014305 0.636976 8.37899601 0.94644073 hsa-miR-1471_st 11.1678 0.665485 10.4022786 0.88944467 hsa-miR-147b_st 4.710862 0.539004 4.66154276 0.35880491 hsa-miR-148a_st 10.876 1.381937 11.3467232 1.35379965 hsa-miR-4299_st 13.56937 0.715054 12.9855045 1.29560853 hsa-miR-135a-star_st 13.41044 0.452887 12.72747 0.7998393 hsa-miR-612_st 12.27801 0.527558 11.6363967 0.75378182 hsa-miR-1321_st 7.800694 0.625883 7.3046568 0.82545588 hsa-miR-149-star_st 15.7825 0.579601 15.539387 0.50116132 hsa-miR-604_st 9.410595 0.601619 8.98749498 1.09741636 hsa-miR-150-star_st 14.39042 0.397546 13.8702233 0.56661051 hsa-miR-125b-1-star_st 12.03885 0.510609 11.5147687 0.68349007 hsa-miR-1183_st 10.46254 0.457036 9.91407393 0.64947921 hsa-miR-152_st 9.983069 1.113642 10.1956863 1.05953698 hsa-miR-153_st 3.753755 0.499191 3.90025313 0.67509779 hsa-miR-1537_st 3.544254 0.482314 3.76585847 0.4795435 hsa-miR-1538_st 8.138589 0.474216 7.83350787 0.64922918 hsa-miR-1539_st 5.873557 0.553469 5.8219744 0.50308612 hsa-miR-154_st 4.757826 0.490487 4.64627724 0.96069642 hsa-miR-154-star_st 4.969782 0.736718 4.76407291 0.89497382 hsa-miR-432-star_st 5.0538 0.649495 4.96343474 0.56447033 hsa-miR-155-star_st 3.68138 0.563039 3.7271668 0.51374138 hsa-miR-298_st 11.08164 0.553009 10.5243045 0.83832428 hsa-miR-15a-star_st 5.04323 0.639444 4.66767205 0.46634104 hsa-miR-2110_st 11.20791 0.659696 10.6376019 0.73598132 hsa-miR-15b-star_st 3.861323 0.520095 3.82552288 0.35127867 hsa-miR-1266_st 9.871099 0.519955 9.21495988 0.66398447 hsa-miR-16-1-star_st 4.506678 0.417781 4.67082683 0.45838599 hsa-miR-16-2-star_st 4.587863 0.582322 4.96267077 0.81359521 hsa-miR-490-5p_st 7.772704 0.712981 7.24444026 0.72053352 hsa-miR-19a_st 5.362558 1.205284 6.68591444 1.36376854 hsa-miR-3192_st 9.269805 0.523768 8.65854263 0.78246497 hsa-miR-3155_st 8.0444 0.520427 7.68563039 0.6627022 hsa-miR-187-star_st 11.4036 0.38155 10.6131607 0.58284327 hsa-miR-16_st 12.9577 0.874914 14.1451377 0.91414373 hsa-miR-936_st 11.30008 0.425683 10.6749869 0.57387014 hsa-miR-181c-star_st 7.423511 0.700312 7.27320662 0.72460569 hsa-miR-379_st 5.900505 0.673361 5.82248801 0.87968533 hsa-miR-370_st 11.52791 0.552752 10.8287245 0.67196726 hsa-miR-541_st 8.817298 0.49997 8.27813082 0.83987041 hsa-miR-518c-star_st 8.815813 0.483748 8.25369724 0.85647824 hsa-miR-487b_st 8.545791 0.924969 9.93495987 0.91614829 hsa-miR-182-star_st 3.526463 0.437325 3.69208954 0.5064464 hsa-miR-3121_st 8.045173 0.825329 7.69154438 1.0003751 hsa-miR-3190-5p_st 10.57986 0.459501 9.94191873 0.76952677 hsa-miR-1203_st 9.303836 0.548117 8.72714881 0.71067448 hsa-miR-185_st 9.233069 0.703361 9.77309887 0.87678544 hsa-miR-185-star_st 9.818401 0.625494 9.256766 0.8406816 hsa-miR-4317_st 10.08478 0.647379 9.65929362 0.61370698 hsa-miR-186-star_st 3.151068 0.536852 3.16501739 0.49804634 hsa-miR-187_st 5.410671 0.694775 5.6881569 1.08404849 hsa-miR-4257_st 12.73521 0.380841 12.0858235 0.69964238 hsa-miR-188-3p_st 4.753711 0.544941 4.91175606 0.50471447 hsa-miR-1184_st 5.223914 0.594474 5.13021174 0.49863843 hsa-miR-18a_st 4.652306 0.624515 5.34774058 0.69489563 hsa-miR-18a-star_st 5.279843 0.672291 5.22757857 0.58618275 hsa-miR-3140_st 5.429276 0.586338 5.25824083 0.56121471 hsa-miR-18b-star_st 4.556296 0.43412 4.49602146 0.56800245 hsa-miR-190_st 3.000131 0.684851 2.90799003 0.67836777 hsa-miR-601_st 6.55051 0.728232 5.98558272 0.6274005 hsa-miR-1909_st 14.91129 0.466363 14.523262 0.53579258 hsa-miR-342-5p_st 5.824628 0.767692 6.33479494 1.08680023 hsa-miR-575_st 13.71488 0.571579 13.0556872 0.84194687 hsa-miR-885-5p_st 7.082986 0.705171 6.63001186 0.82935358 hsa-miR-300_st 6.09385 0.657001 5.72401992 0.71914145 hsa-miR-1911_st 4.43363 0.595786 4.35282976 0.42551039 hsa-miR-1911-star_st 5.474874 0.658405 5.44707453 0.48219626 hsa-miR-1912_st 4.756903 0.401043 4.74886851 0.44521076 hsa-miR-4266_st 7.058794 0.622565 6.5613542 0.69611989 hsa-miR-1914_st 5.933091 0.472271 5.98994525 0.6213241 hsa-miR-3190-3p_st 11.26445 0.391117 10.5551338 0.69587402 hsa-miR-618_st 4.056529 0.529376 4.09823745 0.55298877 hsa-miR-1276_st 7.628428 0.732648 6.95097618 0.76855772 hsa-miR-191-star_st 6.877947 0.797432 6.65568204 0.76292551 hsa-miR-1258_st 5.336432 0.65674 4.98843541 0.48470053 hsa-miR-192-star_st 3.90578 0.444768 4.14022609 0.49228908 hsa-miR-193a-3p_st 7.54646 1.039906 7.85222602 1.05332127 hsa-miR-193a-5p_st 13.13197 0.543668 12.5398464 0.52087754 hsa-miR-3157_st 5.510556 0.397314 5.10961723 0.49942506 hsa-miR-193b-star_st 11.46221 0.522768 10.9791069 0.52186699 hsa-miR-194_st 6.856921 1.382171 8.34760954 1.31545108 hsa-miR-4307_st 3.894476 0.569672 3.85085686 0.59324324 hsa-miR-195_st 11.21602 1.049426 11.5275964 1.36506121 hsa-miR-610_st 5.905776 0.546873 5.68048794 0.57907008 hsa-miR-196a_st 4.516189 0.636584 4.59412885 1.00047501 hsa-miR-196a-star_st 5.924024 0.840354 5.53443168 1.00990487 hsa-miR-196b_st 4.102701 0.485449 4.04742534 0.59084418 hsa-miR-196b-star_st 5.907676 0.554815 5.73416715 0.63995327 hsa-let-7f-2-star_st 3.876969 0.497875 4.02648693 0.41233585 hsa-miR-1972_st 12.5182 0.513316 12.1847632 0.5538262 hsa-miR-3184_st 10.57034 0.620189 9.96773608 0.8452033 hsa-miR-523-star_st 6.608064 0.792583 6.14320694 0.69851611 hsa-miR-1976_st 6.908549 0.785032 6.68599813 0.86808183 hsa-miR-625-star_st 4.640855 0.638232 4.85998914 0.66493379 hsa-miR-587_st 5.08626 0.451682 4.69517571 0.58532861 hsa-miR-199a-3p_st 11.09522 1.29475 11.2147133 1.84542999 hsa-miR-1910_st 9.12995 0.525638 8.6751606 0.62777045 hsa-miR-199b-3p_st 11.18733 1.253928 11.3040812 1.86805297 hsa-miR-639_st 9.430837 0.737202 8.80604054 0.64250866 hsa-miR-1909-star_st 8.852319 0.527047 8.6380658 0.57762219 hsa-miR-19a-star_st 3.248277 0.570135 3.25951135 0.53384864 hsa-miR-29c-star_st 7.412177 0.987097 8.52049852 0.88546126 hsa-miR-940_st 9.142737 0.483829 8.60968464 0.57783102 hsa-miR-19b-2-star_st 3.159456 0.518061 3.09772114 0.51887323 hsa-miR-4269_st 8.759823 0.448679 8.30601513 0.76409129 hsa-miR-200a-star_st 6.786583 0.681635 7.05532548 0.81557213 hsa-miR-1182_st 10.83303 0.373567 10.1913771 0.70060365 hsa-miR-518f-star_st 6.904936 0.546295 6.67131476 0.61257083 hsa-miR-92a-2-star_st 9.340087 0.559116 8.82478712 0.9843132 hsa-miR-200c-star_st 4.285809 0.539298 4.49389333 0.53785296 hsa-miR-202_st 9.494886 0.507772 9.00321838 0.60938362 hsa-miR-202-star_st 2.994445 0.594615 3.09279121 0.66759881 hsa-miR-1914-star_st 13.47372 0.472301 12.9179855 0.65927069 hsa-miR-204_st 7.90583 2.102357 6.50651726 2.25679341 hsa-miR-665_st 13.09387 0.396703 12.651798 0.66511811 hsa-miR-2052_st 3.011014 0.673542 3.21956118 0.60559582 hsa-miR-2053_st 3.642616 0.587171 3.71470981 0.47222552 hsa-miR-2054_st 2.782261 0.843189 2.81005144 0.72992988 hsa-miR-205-star_st 5.567501 0.629178 5.5937037 0.68009279 hsa-miR-206_st 6.360138 0.714237 6.45495418 1.56255028 hsa-miR-208a_st 3.988709 0.591335 4.04108824 0.62465443 hsa-miR-208b_st 3.840507 0.564059 4.0074051 0.38386192 hsa-miR-18b_st 4.317941 0.399829 4.75299489 0.59182495 hsa-miR-20a-star_st 4.08669 0.761749 4.82009614 1.17644656 hsa-miR-3181_st 9.048286 0.551977 8.40383643 0.74854306 hsa-miR-615-5p_st 11.51163 0.63811 11.0233904 0.85555952 hsa-miR-4259_st 11.24691 0.429476 10.5886901 0.53970714 hsa-miR-210_st 13.14354 0.533177 12.5272017 0.55018594 hsa-miR-211_st 5.324104 0.699883 4.88568036 0.52373053 hsa-miR-887_st 9.677032 0.43282 9.1766726 0.61310955 hsa-miR-2113_st 5.1192 0.786091 5.07041276 0.46627215 hsa-miR-2114_st 4.522777 0.619019 4.27711166 0.53249886 hsa-miR-943_st 7.676862 0.632179 7.14169936 0.65822836 hsa-miR-2115_st 3.29828 0.496781 3.5167075 0.62811412 hsa-miR-2115-star_st 10.74665 0.768738 10.4071738 0.90301985 hsa-miR-183-star_st 7.578354 0.601006 7.25041207 0.5974665 hsa-miR-2116-star_st 4.382764 0.611014 4.43305146 0.48331611 hsa-miR-920_st 10.72006 0.547491 10.161402 0.73787489 hsa-miR-212_st 6.381518 0.551417 6.7216838 0.55735742 hsa-miR-214_st 10.74818 0.507169 10.578116 0.71466936 hsa-miR-1825_st 7.046347 0.568985 6.82127986 0.67715213 hsa-miR-215_st 5.718463 1.069816 6.18895156 1.29157609 hsa-miR-216a_st 3.83513 0.353766 3.77428564 0.5446599 hsa-miR-195-star_st 5.630064 0.658875 5.60610538 0.63156415 hsa-miR-217_st 3.462462 0.434731 3.63432158 0.49269356 hsa-miR-23a-star_st 11.11531 0.466606 10.6867179 0.66917242 hsa-miR-25-star_st 12.97714 0.466602 12.4256332 0.74302521 hsa-miR-218-2-star_st 4.510064 0.583866 4.33482032 0.54264988 hsa-miR-1273c_st 10.87996 0.501208 10.4793145 0.82767498 hsa-miR-219-2-3p_st 7.345337 0.452678 6.94335392 0.604779 hsa-miR-637_st 12.37203 0.483499 11.7189133 0.66713904 hsa-miR-21-star_st 6.666717 0.820662 7.26837139 0.91925052 hsa-miR-22_st 11.39475 1.209008 12.1907829 0.84367058 hsa-miR-220a_st 3.41554 0.391169 3.66550572 0.53817747 hsa-miR-220b_st 4.009127 0.536872 4.25943623 0.48269638 hsa-miR-219-1-3p_st 5.880131 0.41131 5.59820794 0.53405259 hsa-miR-4316_st 7.811901 0.539669 7.33102376 0.68199014 hsa-miR-877_st 12.68284 0.404216 12.0653331 0.57820531 hsa-miR-636_st 7.92034 0.645947 7.42920457 0.81254252 hsa-miR-3177_st 12.39135 0.469506 11.7334651 0.61293037 hsa-miR-1249_st 5.192321 0.650324 5.14602263 0.70941235 hsa-miR-223-star_st 4.107594 0.541261 4.50939324 0.53768259 hsa-miR-1224-5p_st 13.77368 0.329311 13.1571558 0.52064089 hsa-miR-564_st 12.58704 0.366432 12.0217239 0.68890318 hsa-miR-2276_st 11.62496 0.557122 10.9767434 0.69654964 hsa-miR-2277_st 7.508897 0.530097 7.15621848 0.71560615 hsa-miR-2278_st 6.574273 0.592552 6.31242414 0.58854562 hsa-miR-22-star_st 7.319068 1.459441 8.38139104 1.22092202 hsa-miR-2355_st 4.45229 0.547746 4.35902824 0.49593076 hsa-miR-769-3p_st 9.79921 0.731407 9.30951524 0.87187279 hsa-miR-1913_st 7.906398 0.52029 7.5443767 0.56587509 hsa-miR-1237_st 7.433565 0.586333 7.158132 0.77084947 hsa-miR-1275_st 13.80187 0.308546 13.3347106 0.6789055 hsa-miR-30a_st 12.24781 1.042277 13.2422955 0.99546162 hsa-miR-20b-star_st 5.93051 0.516315 5.65993576 0.55367313 hsa-miR-24-2-star_st 6.10863 0.959849 7.20035511 1.00686568 hsa-miR-3173_st 10.14315 0.452426 9.59281524 0.74737154 hsa-miR-3148_st 5.688379 0.528645 5.44543494 0.60379501 hsa-miR-4271_st 12.84732 0.335384 12.2097731 0.6799478 hsa-miR-659_st 11.09031 0.456494 10.5973179 0.70208839 hsa-miR-26a-2-star_st 2.926497 0.684608 3.07198249 0.52073345 hsa-miR-1228_st 7.447184 0.687557 6.97441665 0.6510955 hsa-miR-26b-star_st 5.295597 0.59454 6.16374651 0.90640347 hsa-miR-3174_st 7.538033 0.791219 7.37725199 0.73305347 hsa-miR-27a-star_st 5.74851 0.651479 5.85742523 0.78373376 hsa-miR-1285_st 12.8171 0.377748 12.4579705 0.64937845 hsa-miR-483-5p_st 12.11021 0.389285 11.6618691 0.67438196 hsa-miR-1306_st 7.226534 0.437341 6.86211736 0.55081767 hsa-miR-431_st 4.179814 0.517082 4.50994212 0.98337035 hsa-miR-765_st 9.411896 0.416691 8.99438853 0.72723581 hsa-miR-2909_st 4.051542 0.434154 4.25558825 0.47427972 hsa-miR-296-3p_st 11.66792 0.473418 11.1382243 0.5810927 hsa-miR-296-5p_st 4.748007 0.603437 4.95345489 0.77199839 hsa-miR-297_st 5.275717 0.681227 5.04247384 0.66100959 hsa-miR-323b-5p_st 7.656137 0.597688 7.49801768 0.64594115 hsa-miR-299-3p_st 7.60544 0.80098 7.39980863 0.7412039 hsa-miR-299-5p_st 4.187871 0.437855 4.28062801 0.9515708 hsa-miR-487a_st 5.905714 0.64278 6.26788572 0.50311898 hsa-miR-29a-star_st 3.587107 0.518688 3.62520467 0.61848445 hsa-miR-625_st 7.005339 0.586543 7.14900401 0.65749234 hsa-miR-611_st 8.444941 0.7318 8.09734071 0.83860473 hsa-miR-3186-3p_st 9.128762 0.536675 9.1468968 0.69633903 hsa-miR-1294_st 5.949484 0.459751 5.70786726 0.52188169 hsa-miR-3147_st 10.95659 0.430452 10.3402127 0.51976672 hsa-miR-4285_st 11.98503 0.626573 11.3162171 0.85536076 hsa-miR-125a-3p_st 11.87545 0.416548 11.5371485 0.47433146 hsa-miR-301b_st 3.380898 0.511299 3.5384237 0.60934524 hsa-miR-302a_st 3.487983 0.500219 3.53226882 0.51636224 hsa-miR-518e-star_st 6.871526 0.721917 6.55741357 0.62754693 hsa-miR-302b_st 3.097469 0.719737 3.13952956 0.66636298 hsa-miR-302b-star_st 4.473941 0.468379 4.28003453 0.57199119 hsa-miR-302c_st 3.091218 0.528866 3.07109404 0.56695864 hsa-miR-302c-star_st 9.322559 0.520556 8.75764794 0.79378319 hsa-miR-302d_st 3.310685 0.540234 3.27178825 0.49772924 hsa-miR-302d-star_st 8.81876 0.657124 8.54582522 0.83334835 hsa-miR-302e_st 3.483191 0.55328 3.62056265 0.47252215 hsa-miR-302f_st 3.291869 0.558694 3.4660946 0.53620394 hsa-miR-3065-3p_st 5.198465 0.766017 5.2761636 0.86992375 hsa-miR-3130-5p_st 7.295173 0.751871 6.99377791 0.64479453 hsa-miR-3074_st 5.238918 0.519661 5.09982756 0.41671329 hsa-miR-1226-star_st 12.10807 0.441625 11.5540232 0.445895 hsa-miR-3180-5p_st 7.029548 0.587666 6.66773966 0.63189876 hsa-miR-1229_st 7.024116 0.46561 7.38720818 0.57396368 hsa-miR-1272_st 4.695851 0.559417 4.49762795 0.48101175 hsa-miR-30c_st 13.35955 1.077312 14.0569402 0.95764945 hsa-miR-675_st 13.71378 0.543176 13.2156948 0.67167374 hsa-miR-30c-2-star_st 7.538879 0.653015 7.44417634 0.70232822 hsa-miR-1827_st 4.679071 0.530464 4.90573725 0.515662 hsa-miR-30d-star_st 3.72744 0.535907 4.02268804 0.66152951 hsa-miR-30e_st 9.577361 1.245257 10.6078373 1.2364498 hsa-miR-1915-star_st 7.190495 0.680844 7.02434269 0.77579649 hsa-miR-1322_st 4.56829 0.45671 4.42512905 0.52052645 hsa-miR-3115_st 3.632377 0.447203 3.79449863 0.52190118 hsa-miR-3116_st 7.160553 0.809077 6.82579759 1.01804093 hsa-miR-3117_st 4.727633 0.447175 4.61074147 0.60607755 hsa-miR-3118_st 3.733644 0.498701 3.87302011 0.49055634 hsa-miR-519b-5p_st 6.371297 0.620707 6.10313752 0.63292002 hsa-miR-3120_st 6.791567 0.715292 6.44490673 0.73884454 hsa-miR-520d-3p_st 5.592855 0.542073 5.38920015 0.47207332 hsa-miR-326_st 6.013079 0.451521 6.05083719 0.54322182 hsa-miR-3123_st 2.914904 0.638766 2.9945243 0.58600991 hsa-miR-3124_st 12.72199 0.511229 12.2259446 0.62681791 hsa-miR-3125_st 7.694069 0.672695 7.49068981 0.74876288 hsa-miR-3126-3p_st 4.91701 0.491548 4.64334302 0.51987727 hsa-miR-1296_st 6.90035 0.511463 6.76773245 0.50642685 hsa-miR-3127_st 9.480921 0.5958 8.88771639 0.75023462 hsa-miR-3128_st 4.164292 0.358876 4.10721341 0.45186484 hsa-miR-3129_st 4.304161 0.38854 4.37728189 0.420934 hsa-miR-3130-3p_st 9.062106 0.595567 8.49020828 0.79300737 hsa-miR-105-star_st 4.101657 0.438842 3.93230779 0.41293377 hsa-miR-3131_st 12.176 0.445239 11.6946806 0.59437807 hsa-miR-4255_st 4.304628 0.441999 4.12888846 0.43303015 hsa-miR-3133_st 4.535888 1.183533 4.41228356 0.74970779 hsa-miR-3134_st 3.664814 0.507108 3.68434235 0.44503127 hsa-miR-3135_st 6.826625 0.611152 6.40583317 0.67177744 hsa-miR-3136_st 6.417549 0.64608 6.05961106 0.65733355 hsa-miR-19b-1-star_st 4.061083 0.407576 4.3058178 0.49761986 hsa-miR-1247_st 7.399755 0.56329 6.87797483 0.82094957 hsa-miR-3139_st 4.030071 0.397504 4.0847225 0.34945387 hsa-miR-596_st 6.630219 0.560824 6.34566826 0.68980371 hsa-miR-3141_st 14.63752 0.502169 14.1551188 0.54081713 hsa-miR-3142_st 3.228526 0.511483 3.33628987 0.54614208 hsa-miR-1302_st 3.784348 0.422743 3.61928841 0.41365303 hsa-miR-3144-3p_st 4.503057 0.551934 4.45822788 0.45194795 hsa-miR-3144-5p_st 5.473634 0.823243 5.36844046 0.75501648 hsa-miR-3145_st 3.481279 0.556547 3.37235746 0.58691575 hsa-miR-3146_st 4.806779 0.462714 4.59610965 0.65799197 hsa-miR-346_st 8.463695 0.537342 8.16209963 0.54362365 hsa-miR-4256_st 4.252585 0.428697 3.96820977 0.41703709 hsa-miR-3149_st 4.668127 0.508195 4.75573494 0.42668429 hsa-miR-3150_st 10.03205 0.583287 9.67824986 0.66288787 hsa-miR-3151_st 11.92253 0.487621 11.3666685 0.65451608 hsa-miR-1470_st 5.76857 0.484737 5.54979656 0.58428066 hsa-miR-3153_st 9.602147 0.618164 9.14607191 0.66505199 hsa-miR-514_st 3.335725 0.447224 3.44119198 0.51894863 hsa-miR-3175_st 12.96856 0.299339 12.818224 0.40814356 hsa-miR-3156_st 10.56189 0.4400761 0.5236603 0.37037246 hsa-miR-504_st 5.723855 0.588638 5.78217385 0.76664166 hsa-miR-3158_st 4.957519 0.728669 4.83228459 0.75523666 hsa-miR-3159_st 5.224462 0.510264 4.9953311 0.60751679 hsa-miR-3160_st 5.967081 0.650586 5.82750267 0.52071591 hsa-miR-3161_st 7.74174 0.992511 7.55017928 0.9167566 hsa-miR-3162_st 13.69697 0.350751 13.1835403 0.52519718 hsa-miR-1234_st 7.522424 0.471347 7.26479761 0.54590782 hsa-miR-3164_st 7.934438 0.693833 7.26708431 0.86761343 hsa-miR-516b-star_st 3.891291 0.443377 4.12304902 0.47847515 hsa-miR-3166_st 4.859359 0.424716 4.99582314 0.45108985 hsa-miR-4327_st 12.98085 0.429377 12.3343606 0.57077669 hsa-miR-3168_st 3.356534 0.493178 3.51162735 0.53724399 hsa-miR-3169_st 4.7004 0.457484 4.50867162 0.37410857 hsa-miR-3170_st 6.866305 0.750592 6.54416701 0.7710439 hsa-miR-3171_st 3.473133 0.446955 3.51801041 0.49328237 hsa-miR-3172_st 15.09805 0.755682 15.4141307 0.80483 hsa-miR-374b-star_st 3.741407 0.348141 4.06635283 0.5645087 hsa-miR-34c-5p_st 4.082741 0.371525 4.44666858 1.03597985 hsa-miR-758_st 3.658324 0.517302 3.69189652 0.76661976 hsa-miR-3176_st 11.91393 0.999656 11.8241466 0.74629134 hsa-miR-606_st 3.192972 0.506689 3.43406738 0.48633196 hsa-miR-3178_st 15.48585 0.510856 15.1609346 0.56100051 hsa-miR-3179_st 4.561842 0.868057 4.41737193 0.69982633 hsa-miR-3180-3p_st 14.78645 0.521448 14.3884118 0.60103458 hsa-miR-597_st 3.375527 0.531771 3.68733555 0.579442 hsa-miR-148b-star_st 3.353429 0.459222 3.67882454 0.65145919 hsa-miR-3182_st 4.134859 0.521338 4.18415679 0.55662767 hsa-miR-3183_st 6.107105 0.599916 5.72577147 0.55515728 hsa-miR-144-star_st 3.795629 0.537974 4.0415967 0.6441144 hsa-miR-3185_st 15.2779 0.555308 14.8536058 0.53780496 hsa-miR-4270_st 15.3228 0.454482 14.9270537 0.44340183 hsa-miR-3186-5p_st 5.55249 0.627668 5.3504552 0.61661896 hsa-miR-3187_st 13.49394 0.494512 12.8984145 0.59160091 hsa-miR-3188_st 14.00477 0.498515 13.354323 0.50134359 hsa-miR-3189_st 8.046312 0.717761 7.5100952 0.63406501 hsa-miR-548b-3p_st 3.75837 0.527389 3.92393399 0.60290205 hsa-miR-99a-star_st 4.904107 0.561379 5.28278655 0.91580408 hsa-miR-376a-star_st 2.947652 0.608765 3.09117543 0.65034026 hsa-miR-216b_st 3.847461 0.462002 4.18210728 0.53565292 hsa-miR-3193_st 6.892475 0.506815 6.77460892 0.54830453 hsa-miR-548v_st 3.260885 0.546773 3.4425624 0.55774687 hsa-miR-26a-1-star_st 3.511849 0.533379 3.39882581 0.41049936 hsa-miR-1291_st 9.050779 0.63812 8.86208373 0.8751353 hsa-miR-3197_st 15.20793 0.456222 14.7916453 0.613482 hsa-miR-629_st 7.743164 0.619386 8.2737559 0.63210909 hsa-miR-3199_st 5.593028 0.568101 5.51927359 0.65670565 hsa-miR-190b_st 3.090465 0.552555 3.24131796 0.51288518 hsa-miR-32_st 3.185348 0.593975 3.56481968 0.62000975 hsa-miR-3200_st 4.17715 0.468426 4.57396482 0.65615804 hsa-miR-3201_st 4.267973 0.504037 4.07083997 0.57408862 hsa-miR-3202_st 7.949926 0.86704 7.78409209 0.79332959 hsa-miR-320a_st 12.33395 0.43992 12.3652897 0.43638929 hsa-miR-4289_st 6.724997 0.693183 7.03055474 0.70200839 hsa-miR-655_st 3.052842 0.590458 3.32863594 0.60330143 hsa-miR-320b_st 11.34285 0.479626 11.6066704 0.66364498 hsa-miR-219-5p_st 3.070874 0.71297 3.3939776 0.6240275 hsa-miR-323-3p_st 4.370783 0.453501 4.47349771 0.73239938 hsa-miR-323-5p_st 11.14189 0.663054 10.4644945 0.71084037 hsa-miR-323b-3p_st 4.066809 0.639045 4.0036625 0.50797183 hsa-miR-103-as_st 3.886225 0.504493 4.33234024 0.48018738 hsa-miR-424-star_st 8.632444 0.433792 9.0418152 0.64384415 hsa-miR-33a-star_st 3.829405 0.623432 4.53181593 0.77903827 hsa-miR-325_st 4.967083 0.721525 4.67546839 0.83335797 hsa-miR-590-3p_st 3.2437 0.527488 3.29693449 0.71216016 hsa-miR-328_st 7.833323 0.740985 8.31790367 1.11451196 hsa-miR-329_st 3.894032 0.482935 4.36295644 1.02529234 hsa-miR-32-star_st 4.927833 0.478206 4.9257615 0.55632544 hsa-miR-330-3p_st 6.597377 0.51527 6.70560497 0.58792932 hsa-miR-330-5p_st 6.286831 0.610344 6.03818569 0.63197768 hsa-miR-146a-star_st 3.073914 0.521667 3.49961338 0.56226189 hsa-miR-331-5p_st 7.183827 0.577797 7.48843067 0.73426129 hsa-miR-3167_st 3.426018 0.427286 3.27558859 0.47420154 hsa-miR-335-star_st 3.958195 0.752706 3.9914167 0.75991322 hsa-miR-337-3p_st 4.499582 0.678846 4.29293712 0.55032248 hsa-miR-337-5p_st 3.9586 0.469901 4.04647209 0.56852148 hsa-miR-421_st 6.960999 0.658287 7.71710635 0.72901283 hsa-miR-338-5p_st 5.636557 0.432382 6.02253919 0.74880317 hsa-miR-339-3p_st 8.836054 0.518838 9.07904072 0.54197073 hsa-miR-548a-5p_st 4.496835 0.454132 4.74687915 0.39000992 hsa-miR-33a_st 3.07625 0.554997 3.1554349 0.67587877 hsa-miR-590-5p_st 3.523502 0.509156 4.02123453 0.71365623 hsa-miR-33b_st 3.39599 0.456871 3.56046677 0.54830819 hsa-miR-616-star_st 3.999118 0.524463 4.35974257 0.52361252 hsa-miR-569_st 3.841971 0.506813 3.88670845 0.49944099 hsa-miR-340-star_st 3.159949 0.506138 3.39729259 0.71232231 hsa-miR-342-3p_st 10.50075 1.195893 11.4170159 1.12296604 hsa-miR-135b-star_st 8.470475 0.891634 8.22988542 0.89613074 hsa-miR-345_st 10.30203 1.318505 10.8398276 1.41895486 hsa-miR-1288_st 5.280472 0.443864 4.97420276 0.43455924 hsa-miR-135a_st 3.123487 0.615175 3.45583379 0.84785539 hsa-miR-34a-star_st 5.505559 1.007936 6.91782236 1.34602229 hsa-miR-34b_st 5.204223 0.607549 5.27972121 0.68271962 hsa-miR-4288_st 4.475043 0.54204 5.01688664 0.5543019 hsa-miR-222-star_st 6.106742 0.909655 7.72599786 1.27140568 hsa-miR-933_st 11.2424 0.659944 11.7602279 0.62488114 hsa-miR-361-3p_st 6.651218 0.958945 7.54430313 0.95679198 hsa-miR-224-star_st 5.804651 0.474078 6.45540807 0.79859114 hsa-miR-362-3p_st 4.477435 0.865007 5.08892217 1.1270098 hsa-miR-362-5p_st 6.759382 0.720225 7.57210815 1.00828903 hsa-miR-363_st 5.718796 0.905945 6.01887139 1.36057189 hsa-miR-363-star_st 9.854413 0.618135 9.44281281 0.71875925 hsa-miR-1979_st 15.23059 0.659874 15.4654283 0.61680383 hsa-miR-365-star_st 12.33801 0.44289 11.6801618 0.56165947 hsa-miR-548x_st 3.005415 0.624034 3.19707894 0.67098945 hsa-miR-367-star_st 3.192781 0.582819 3.42140022 0.61720824 hsa-miR-369-3p_st 3.099533 0.513888 3.17872537 0.65428451 hsa-miR-369-5p_st 3.863914 0.349865 4.2476199 0.81772146 hsa-miR-548l_st 5.416045 0.490895 5.05825615 0.52841223 hsa-miR-371-3p_st 4.055385 0.441545 4.08350367 0.44632772 hsa-miR-371-5p_st 13.07245 0.515766 12.3968184 0.54398317 hsa-miR-372_st 4.449338 0.643097 4.23951688 0.39848701 hsa-miR-373_st 5.438272 0.601778 5.23734577 0.52330417 hsa-miR-373-star_st 12.34867 0.561983 11.6452636 0.65654465 hsa-miR-374a_st 4.636737 1.172011 5.56304278 1.31405758 hsa-miR-374a-star_st 3.574642 0.492143 3.88051884 0.51664318 hsa-miR-500_st 6.445738 0.645955 6.98979085 0.73691867 hsa-miR-320c_st 10.81818 0.65127 11.2028649 0.78211289 hsa-miR-875-3p_st 4.703813 0.40937 4.60366518 0.37552284 hsa-miR-376a_st 4.482481 0.692729 4.72564609 0.95050282 hsa-miR-29b-1-star_st 6.24022 0.726633 7.62149452 0.90431086 hsa-miR-376b_st 3.637573 0.484211 3.83434675 0.73888442 hsa-miR-376c_st 4.692923 0.919456 5.16942409 1.46401293 hsa-miR-377_st 3.596003 0.460698 3.64103045 0.84459352 hsa-miR-377-star_st 5.022027 0.667778 5.12315423 0.59711685 hsa-miR-378_st 9.023316 0.481853 9.21974786 1.13420711 hsa-miR-378b_st 9.152552 0.398945 8.79293666 0.50636488 hsa-miR-378c_st 9.324971 0.462952 9.32843634 0.85523297 hsa-miR-378-star_st 5.410873 0.447244 5.62438861 0.72935466 hsa-miR-662_st 7.130306 0.588838 7.89389425 0.79891862 hsa-miR-379-star_st 3.507107 0.539389 3.73461014 0.47555469 hsa-miR-380_st 3.462347 0.479189 3.56004782 0.57096373 hsa-miR-380-star_st 3.792815 0.44919 3.77925687 0.4834703 hsa-miR-1274b_st 14.24856 0.805557 15.0939516 0.64714015 hsa-miR-382_st 6.732189 0.526563 6.67731615 1.01707887 hsa-miR-383_st 6.337119 0.654392 6.0955376 0.6368297 hsa-miR-384_st 3.017593 0.605746 3.16667199 0.56585892 hsa-miR-126-star_st 3.489964 0.593257 3.57912631 0.59289848 hsa-miR-409-5p_st 4.571669 0.400622 4.6291478 0.55813454 hsa-miR-410_st 4.438634 0.323714 4.55839528 0.61591152 hsa-miR-411_st 4.585955 0.478241 4.62169062 0.58527949 hsa-miR-411-star_st 4.506773 0.498141 4.74029158 0.58905879 hsa-miR-412_st 5.14131 0.695059 4.91085477 0.40064634 hsa-miR-3143_st 3.251294 0.592874 3.2019943 0.68003472 hsa-miR-422a_st 9.865196 0.389244 9.86248215 0.77199038 hsa-miR-628-5p_st 3.795382 0.51616 4.23440721 0.6887173 hsa-miR-423-5p_st 13.59708 0.33684 13.1924806 0.42957103 hsa-miR-27b-star_st 6.210673 0.692693 7.55600605 0.72431805 hsa-miR-499-5p_st 3.86941 0.509375 4.46211531 0.82640057 hsa-miR-425_st 7.93508 1.124078 9.39941342 1.19158046 hsa-miR-193b_st 8.389325 1.217186 8.89681573 1.55820002 hsa-miR-4252_st 5.581837 0.434368 5.40953811 0.3989544 hsa-miR-4253_st 12.48343 0.492355 11.9432648 0.56793561 hsa-miR-4254_st 5.54837 0.59345 5.92594763 0.67038658 hsa-miR-324-3p_st 8.478484 0.583228 8.84526556 0.6639283 hsa-miR-4329_st 5.418088 0.524544 6.00249289 0.60048704 hsa-miR-1251_st 4.78554 0.609984 5.49829992 1.00945316 hsa-miR-4258_st 6.225926 0.699167 5.96051783 0.53546304 hsa-miR-1274a_st 10.55955 1.310195 11.9561369 0.93505051 hsa-miR-425-star_st 8.190254 0.450253 8.15469243 0.46760782 hsa-miR-4260_st 11.40847 0.475864 10.8592329 0.67178459 hsa-miR-4261_st 9.242025 0.521913 9.11020763 0.63120292 hsa-miR-4262_st 3.438188 0.536427 3.33774159 0.58025607 hsa-miR-4263_st 3.614392 0.385649 3.63672359 0.49692175 hsa-miR-4264_st 3.319984 0.462291 3.36627508 0.51985226 hsa-miR-1280_st 14.71578 0.840208 15.2467969 0.66100378 hsa-miR-132-star_st 4.280994 0.534235 5.47483704 1.39927309 hsa-miR-4267_st 7.061295 0.686072 6.7428723 0.54594867 hsa-miR-4268_st 3.783659 0.427158 3.7610505 0.62835083 hsa-miR-133a_st 5.982869 1.372575 6.24329978 2.19043142 hsa-miR-888-star_st 3.610145 0.548088 3.67991398 0.6132167 hsa-miR-1260b_st 14.82574 0.835098 15.392403 0.63811604 hsa-miR-4272_st 3.47699 0.489957 3.52486562 0.48349446 hsa-miR-4273_st 3.421672 0.495347 3.42999535 0.47380105 hsa-miR-4274_st 5.721386 0.399178 5.75269271 0.60431264 hsa-miR-4275_st 3.003178 0.564367 3.27753422 0.53135187 hsa-miR-4276_st 3.14034 0.633284 3.28994234 0.54521572 hsa-miR-4277_st 3.911188 0.427129 3.88289138 0.51752009 hsa-miR-4278_st 7.557067 0.661615 7.21779511 0.72547911 hsa-miR-4279_st 5.160887 0.642726 5.10971592 0.47616144 hsa-miR-4280_st 4.866567 0.651411 4.72243706 0.60563682 hsa-miR-4281_st 15.79123 0.598525 15.5460375 0.48164337 hsa-miR-4282_st 2.89293 0.451322 2.98124179 0.55963954 hsa-miR-4283_st 8.898519 0.522733 8.3747562 0.77248253 hsa-miR-4284_st 15.24454 0.740276 15.5341647 0.75142644 hsa-miR-23b-star_st 6.053939 0.595331 6.72867297 0.81386648 hsa-miR-574-3p_st 9.376738 0.847757 9.87041869 0.88650414 hsa-miR-4287_st 5.99126 0.632647 5.66087059 0.5206105 hsa-miR-320e_st 9.707901 0.699655 10.3660527 0.82396224 hsa-miR-339-5p_st 7.80776 1.124566 8.87590386 1.00393661 hsa-miR-505_st 5.843533 0.858985 6.66046067 1.09851375 hsa-miR-4290_st 5.99431 0.8299 5.91956479 0.73136108 hsa-miR-200b-star_st 7.077419 0.570595 7.54983797 1.11065203 hsa-miR-4292_st 8.704875 0.541092 8.14338347 0.73826757 hsa-miR-4293_st 5.216492 0.65563 5.02094834 0.53772545 hsa-miR-1246_st 13.26622 0.575666 13.7145373 0.68279781 hsa-miR-4295_st 3.580301 0.432054 3.66800483 0.511011 hsa-miR-4296_st 7.418634 0.672207 6.99650716 0.62783237 hsa-miR-4297_st 5.616406 0.950787 5.39385531 0.75015773 hsa-miR-4298_st 13.21964 0.314554 12.7102554 0.54889567 hsa-miR-218_st 5.411662 1.070348 6.9434086 1.54272718 hsa-miR-4286_st 13.90234 1.156584 14.8889175 0.71083579 hsa-miR-4301_st 3.274693 0.608205 3.5209961 0.73725687 hsa-miR-4302_st 6.351504 0.684166 5.95340305 0.52403012 hsa-miR-365_st 4.901677 1.020452 5.22420174 1.00715641 hsa-miR-4304_st 6.922901 0.821131 6.59789057 0.76151483 hsa-miR-4305_st 3.958309 0.572152 4.09029581 0.5724331 hsa-miR-4306_st 9.382493 0.54642 9.56618029 0.71024414 hsa-miR-26a_st 14.44511 0.849545 15.1766251 0.73408249 hsa-miR-4308_st 3.54228 0.541698 3.66878775 0.52848429 hsa-miR-4309_st 4.382955 0.371151 4.50123913 0.41470692 hsa-miR-186_st 6.114806 0.94683 7.09673473 1.34625136 hsa-miR-4310_st 5.647787 0.836996 5.32953346 0.86168613 hsa-miR-4311_st 5.716136 0.600937 5.61624172 0.55189471 hsa-miR-4312_st 6.444188 0.661073 6.12500058 0.80599854 hsa-miR-4313_st 5.997393 0.598278 6.0552011 0.48793013 hsa-miR-4314_st 9.528721 0.725752 8.95564551 1.13974391 hsa-miR-4315_st 4.53505 0.686156 4.48984093 0.57823059 hsa-miR-149_st 6.414102 0.663122 7.4058717 1.17292168 hsa-miR-106b-star_st 7.490213 0.653656 8.24710094 0.80436565 hsa-miR-4318_st 4.900414 0.448643 4.77462316 0.40635958 hsa-miR-4319_st 4.848578 0.733648 4.8486114 0.62689495 hsa-miR-29b-2-star_st 7.401457 0.660914 8.37233542 0.69725353 hsa-miR-432_st 7.842229 0.574901 7.41811807 0.84475303 hsa-miR-4320_st 4.102699 0.423987 4.24454038 0.44298839 hsa-miR-522_st 3.995208 0.523267 4.03370672 0.59723027 hsa-miR-4322_st 13.44026 0.525556 12.8168962 0.50658407 hsa-miR-4323_st 5.305741 0.579646 5.14149768 0.49121558 hsa-miR-93-star_st 5.092212 0.647852 5.86163896 0.66531905 hsa-miR-4325_st 3.44381 0.553924 3.67119081 0.57265843 hsa-miR-4326_st 4.995116 0.418015 5.00342016 0.44784406 hsa-miR-874_st 13.12208 0.500459 12.6181094 0.52161199 hsa-miR-4328_st 3.406979 0.501841 3.52920794 0.46670436 hsa-let-7e-star_st 4.577797 0.56767 5.4166649 0.80311751 hsa-miR-720_st 15.68662 0.689857 15.8460648 0.68895065 hsa-miR-433_st 5.951695 0.602062 5.65434308 0.61989667 hsa-miR-4330_st 5.537312 1.047828 5.43901994 1.02422832 hsa-miR-448_st 3.983789 0.636383 3.89808326 0.4595336 hsa-miR-449a_st 3.94546 0.345635 4.31204086 0.6831466 hsa-miR-449b_st 5.331669 0.519455 5.35550478 0.47661579 hsa-miR-1975_st 15.72165 0.603304 15.7873879 0.53102109 hsa-miR-449c_st 7.707047 1.004191 7.0925273 0.81846888 hsa-miR-449c-star_st 4.619954 0.391777 4.49859221 0.61588559 hsa-miR-1_st 5.048139 1.203957 5.62481631 2.18671333 hsa-miR-450b-3p_st 2.963581 0.597882 3.02656302 0.59769935 hsa-miR-450b-5p_st 3.024492 0.642531 3.15571341 0.69457909 hsa-miR-451_st 13.09447 1.088968 13.1823818 1.36373878 hsa-miR-452_st 6.89586 0.680286 7.04214188 0.98586868 hsa-miR-452-star_st 3.766212 0.348038 3.75236573 0.45794567 hsa-miR-548b-5p_st 4.28699 0.448481 4.06331629 0.47432124 hsa-miR-454-star_st 3.846234 0.519613 3.99982615 0.65287472 hsa-miR-455-3p_st 8.120562 0.982113 8.54959167 1.19648838 hsa-miR-455-5p_st 4.374861 0.763842 4.70894293 0.94706117 hsa-miR-466_st 5.581714 0.822872 5.81929646 0.64127151 hsa-miR-483-3p_st 6.509845 0.64951 6.50626594 0.7131139 hsa-miR-17_st 9.79197 1.024657 11.0722725 1.22014996 hsa-miR-320d_st 9.937922 0.827667 10.5477279 0.92712929 hsa-miR-485-3p_st 5.775795 0.661254 5.82710954 0.84327991 hsa-miR-485-5p_st 7.378994 0.660122 7.00475322 0.67126201 hsa-miR-486-3p_st 10.82569 0.705103 10.3459594 0.81830238 hsa-miR-486-5p_st 8.702254 1.160757 8.18569382 1.4008656 hsa-miR-644_st 3.603317 0.488474 3.58195274 0.48914084 hsa-miR-3152_st 7.816206 0.855584 7.17050225 0.83648413 hsa-miR-488_st 3.655323 0.470916 3.82583644 0.52037269 hsa-miR-488-star_st 3.76761 0.552798 3.7876456 0.48068826 hsa-miR-450a_st 4.239673 0.612996 5.41678463 1.25037701 hsa-miR-20a_st 9.264828 1.25689 10.7857162 1.2087414 hsa-miR-484_st 7.89797 0.865901 8.67748389 0.91345554 hsa-miR-491-3p_st 4.795182 0.455728 5.0025796 0.78658515 hsa-miR-491-5p_st 9.393372 0.476622 9.35477015 0.53315181 hsa-miR-197_st 7.507565 0.861805 8.17656423 1.21778923 hsa-miR-493_st 5.773862 0.56158 5.83422506 0.55501001 hsa-miR-493-star_st 4.373008 0.532062 4.76621919 1.02994215 hsa-miR-494_st 15.32919 0.634427 14.8116457 0.86601387 hsa-miR-495_st 3.839973 0.642191 4.42929326 1.17138718 hsa-miR-496_st 3.281923 0.423251 3.42757916 0.50803811 hsa-miR-497_st 8.783128 1.276071 9.03420629 1.24078123 hsa-miR-497-star_st 3.590765 0.384453 3.68907471 0.52598146 hsa-miR-498_st 12.36457 0.479427 11.7317108 0.60922714 hsa-miR-499-3p_st 3.959258 0.365279 4.14673596 0.41970242 hsa-miR-24-1-star_st 4.241738 0.911295 5.3154219 1.01210908 hsa-miR-340_st 5.039813 0.975807 6.3171148 1.24834241 hsa-miR-500b_st 4.883788 0.505497 5.17853319 0.60974842 hsa-miR-500-star_st 9.454917 0.404851 9.27881846 0.53102515 hsa-miR-501-3p_st 9.489702 0.396711 9.19382791 0.41988179 hsa-miR-501-5p_st 6.366745 0.507204 6.39551152 0.58207992 hsa-miR-502-3p_st 9.215907 0.37784 9.03401862 0.70624163 hsa-miR-502-5p_st 5.38639 0.474146 5.4049096 0.43908919 hsa-miR-503_st 10.85252 0.687416 10.4574649 0.57696176 hsa-miR-192_st 7.16421 1.283466 8.57242898 1.2569885 hsa-let-7g_st 13.26945 0.940059 14.2205466 0.76825716 hsa-miR-505-star_st 7.603197 0.485573 7.48544292 0.61411802 hsa-miR-506_st 3.840776 0.456902 3.9209644 0.54489314 hsa-miR-507_st 3.49053 0.538168 3.59760566 0.54359176 hsa-miR-508-3p_st 3.322743 0.573838 3.49436893 0.61462929 hsa-miR-508-5p_st 9.329902 0.586465 8.92019429 0.64462028 hsa-miR-509-3-5p_st 7.170518 0.954568 6.94556958 0.86770187 hsa-miR-509-3p_st 6.0357 0.569391 5.83742865 0.67735157 hsa-miR-106a_st 9.580399 1.050156 10.9678413 1.20305162 hsa-miR-106b_st 8.560082 1.145483 10.0632788 1.14719127 hsa-miR-511_st 3.28459 0.5506 3.22672588 0.4977934 hsa-miR-512-3p_st 5.404369 0.60803 5.1041096 0.41144425 hsa-miR-512-5p_st 5.902081 0.64687 5.712204 0.52211898 hsa-miR-513a-3p_st 2.994974 0.566369 3.14280657 0.63463867 hsa-miR-23a_st 13.84016 0.944088 14.7248576 0.93867496 hsa-miR-25_st 10.16535 1.016639 11.3504046 0.93370536 hsa-miR-598_st 5.949416 0.912461 7.17584265 1.10670963 hsa-miR-1260_st 11.09415 0.984005 12.1430687 0.85562814 hsa-miR-514b-3p_st 3.62973 0.485733 3.66120933 0.59376863 hsa-miR-514b-5p_st 11.22534 0.481423 10.792225 0.63788446 hsa-miR-515-3p_st 4.337475 0.492399 4.21287078 0.52694377 hsa-miR-515-5p_st 3.636275 0.493366 3.57128743 0.47186337 hsa-miR-516a-3p_st 3.874549 0.482899 3.94242832 0.47584692 hsa-miR-27a_st 11.90714 1.077963 13.250889 1.05383889 hsa-miR-100_st 12.23844 1.076291 12.9411831 1.08306592 hsa-miR-101_st 5.712467 1.184111 7.18380992 1.42488449 hsa-miR-517a_st 3.223932 0.600189 3.4188867 0.53290134 hsa-miR-517b_st 3.750063 0.377614 3.90609688 0.4930514 hsa-miR-517c_st 2.829136 0.557962 2.87674096 0.50174656 hsa-miR-517-star_st 5.420155 0.565331 5.31236377 0.45935484 hsa-miR-518a-3p_st 3.763268 0.505304 3.66876317 0.40393229 hsa-miR-518a-5p_st 7.475702 0.785792 7.06197331 0.87873414 hsa-miR-518b_st 4.12342 0.561781 4.21222673 0.52155971 hsa-miR-518c_st 3.099383 0.515476 3.1984902 0.5989285 hsa-miR-301a_st 4.246788 0.835949 5.47677515 1.05413779 hsa-miR-518d-3p_st 4.241136 0.339449 4.17109377 0.48445969 hsa-miR-518d-5p_st 6.815643 0.645825 6.70277484 0.71478134 hsa-miR-518e_st 3.042633 0.482675 3.33469849 0.5861646 hsa-let-7f_st 14.23317 0.925492 15.0157695 0.69288509 hsa-miR-518f_st 3.243074 0.566673 3.34818081 0.64342434 hsa-miR-1826_st 15.84369 0.630797 15.8044054 0.64118187 hsa-miR-519a_st 3.102453 0.617387 3.05705037 0.56978104 hsa-miR-519a-star_st 6.292434 0.800573 5.91004117 0.69477031 hsa-miR-519b-3p_st 3.391533 0.673187 3.48370995 0.57490958 hsa-miR-1283_st 3.974093 0.36236 3.82132284 0.48529743 hsa-miR-519c-3p_st 2.763353 0.597868 2.77564533 0.67459092 hsa-miR-519c-5p_st 6.619341 0.750737 6.32971949 0.86214798 hsa-miR-519d_st 3.780949 0.414049 3.90846648 0.54149127 hsa-miR-519e_st 3.859283 0.464531 4.2863061 0.56499953 hsa-miR-519e-star_st 7.364359 0.893006 6.97192634 0.64670384 hsa-miR-520a-3p_st 3.713982 0.48883 3.78797954 0.55124523 hsa-miR-1908_st 15.86571 0.66346 15.8169227 0.64455528 hsa-miR-520b_st 3.395918 0.477902 3.49234122 0.41356443 hsa-miR-520c-3p_st 4.1761 0.457159 4.28010158 0.52891463 hsa-miR-520c-5p_st 6.898663 0.726649 6.85487436 0.63179145 hsa-miR-181a-star_st 5.624778 1.056565 6.85626107 1.02657788 hsa-miR-21_st 11.22082 1.568694 13.6241237 1.457782 hsa-miR-520e_st 3.399161 0.552609 3.37877863 0.58115922 hsa-miR-520f_st 3.615821 0.570402 3.88710761 0.41264357 hsa-miR-520g_st 3.65981 0.469938 3.72944274 0.59827373 hsa-miR-520h_st 3.790587 0.515831 3.85926728 0.47191293 hsa-miR-521_st 3.605736 0.424582 3.93641888 0.57997103 hsa-miR-302a-star_st 4.062561 0.51412 3.92646632 0.40902817 hsa-miR-886-3p_st 11.01403 1.293679 11.9191302 1.18380636 hsa-miR-523_st 3.515156 0.48083 3.54230355 0.57369949 hsa-miR-29a_st 12.96012 1.134281 14.3356242 0.99042952 hsa-miR-524-3p_st 4.331525 0.486411 4.13337971 0.46221807 hsa-miR-142-3p_st 3.190812 0.672238 3.179795 0.78721002 hsa-miR-525-3p_st 3.667337 0.501324 3.45615634 0.53142411 hsa-miR-525-5p_st 6.49846 0.63598 6.39949527 0.62196612 hsa-miR-762_st 15.86588 0.663213 15.783934 0.60212851 hsa-miR-423-3p_st 9.258395 0.708732 10.2291543 0.78826496 hsa-miR-449b-star_st 7.926721 0.708969 7.58301053 0.69732249 hsa-miR-527_st 7.712253 0.75801 7.30018728 0.7494596 hsa-miR-532-3p_st 7.89441 0.904689 8.33079 0.86947854 hsa-miR-532-5p_st 7.947601 0.883256 8.5081953 0.82768072 hsa-miR-539_st 4.500196 0.588345 4.69314062 0.59597677 hsa-let-7a_st 14.31841 0.914189 15.0463656 0.61498521 hsa-miR-541-star_st 6.573895 0.478082 6.34530855 0.49970764 hsa-miR-542-3p_st 6.804265 0.992739 7.07715023 1.2745053 hsa-miR-542-5p_st 7.681975 0.538284 8.36918251 0.65137291 hsa-miR-543_st 4.994683 0.443972 5.03755994 0.83926679 hsa-miR-544_st 3.084294 0.655135 3.12600645 0.63498258 hsa-miR-544b_st 4.125303 0.484133 3.98662235 0.43445393 hsa-miR-545_st 3.238889 0.582825 3.25339113 0.60545204 hsa-miR-545-star_st 2.672494 0.644092 2.94542447 0.65516109 hsa-miR-548a-3p_st 2.978628 0.635474 3.06031912 0.68061935 hsa-miR-2861_st 15.87275 0.672343 15.7986233 0.61139366 hsa-miR-31_st 8.440254 1.863791 11.1964669 3.10840587 hsa-miR-367_st 3.292134 0.661369 3.26677948 0.60284233 hsa-miR-548c-3p_st 2.737987 0.80695 3.04263323 0.76570793 hsa-miR-548c-5p_st 4.904636 0.881415 5.11002594 0.69642675 hsa-miR-548d-3p_st 3.580087 0.531378 3.69483712 0.57932925 hsa-miR-548d-5p_st 4.523206 0.630285 4.62630546 0.60136075 hsa-miR-548e_st 3.10315 0.578037 3.1343633 0.59012984 hsa-miR-548f_st 3.3415 0.594306 3.3902609 0.54773622 hsa-miR-548g_st 2.991687 0.741289 3.13434961 0.72528329 hsa-miR-548h_st 3.667037 0.535998 4.03062696 0.48667257 hsa-miR-548i_st 4.372465 0.483515 4.41301748 0.50912062 hsa-miR-548j_st 4.708382 0.525985 4.59511735 0.51477175 hsa-miR-548k_st 3.72579 0.438241 3.78470023 0.44518082 hsa-miR-526b-star_st 3.357738 0.608487 3.33495448 0.61714466 hsa-miR-548m_st 3.950536 0.429382 3.88094571 0.53354887 hsa-miR-548n_st 3.377699 0.480864 3.5718754 0.54451641 hsa-miR-548o_st 2.924489 0.583211 3.03013544 0.55306492 hsa-miR-548p_st 3.136836 0.519217 3.20336691 0.59583593 hsa-miR-548q_st 9.800167 0.711229 9.0359398 0.86935363 hsa-miR-548s_st 3.36516 0.460472 3.3430032 0.49911645 hsa-miR-548t_st 4.135269 0.48972 4.08933053 0.54602671 hsa-miR-548u_st 3.099664 0.670893 3.43524819 0.76055943 hsa-miR-638_st 15.87497 0.674232 15.8642733 0.69383676 hsa-miR-548w_st 4.628354 0.672221 4.69124433 0.65516668 hsa-miR-3119_st 3.131661 0.599412 3.01071918 0.53389413 hsa-miR-549_st 4.087185 0.398277 4.06740003 0.47263172 hsa-miR-205_st 6.382853 1.872936 7.30235676 3.24162491 hsa-miR-550-star_st 4.781098 0.482277 5.2048318 0.78400216 hsa-miR-551a_st 4.642474 0.352147 4.61607942 0.60103223 hsa-miR-93_st 9.274462 0.930166 10.5909162 0.89380237 hsa-miR-551b-star_st 11.54558 0.463516 11.5685504 0.49574194 hsa-let-7d-star_st 8.01121 0.888434 8.73627063 1.44440283 hsa-miR-553_st 3.477332 0.519658 3.70598808 0.4875743 hsa-miR-554_st 4.233594 0.475235 4.15368728 0.43677016 hsa-miR-555_st 4.196198 0.420081 4.01222228 0.42637863 hsa-miR-556-3p_st 3.62307 0.607436 3.457876 0.54916026 hsa-miR-556-5p_st 3.131472 0.670532 3.26558836 0.5140776 hsa-miR-557_st 12.38797 0.500908 11.8334731 0.63095953 hsa-miR-558_st 3.364199 0.512671 3.56553553 0.48236096 hsa-miR-559_st 3.448604 0.543165 3.52031487 0.55445041 hsa-miR-561_st 3.390146 0.575099 3.43733463 0.54899155 hsa-miR-562_st 3.360453 0.588345 3.41536786 0.52407007 hsa-miR-563_st 4.188824 0.486736 4.19879075 0.46450831 hsa-miR-361-5p_st 10.74843 0.808392 11.8573382 0.82064345 hsa-miR-566_st 6.748361 0.548755 6.45831976 0.45860744 hsa-miR-567_st 4.205559 0.477944 3.99911103 0.60398126 hsa-miR-568_st 3.252494 0.600258 3.25321751 0.61304382 hsa-miR-29c_st 11.25493 1.106231 12.5832332 1.09863175 hsa-miR-570_st 3.35764 0.532831 3.57219239 0.49039663 hsa-miR-571_st 4.460428 0.447366 4.39919835 0.47158971 hsa-miR-572_st 14.65858 0.554941 14.1112417 0.57770232 hsa-miR-573_st 3.450177 0.50741 3.48885443 0.49134066 hsa-miR-132_st 6.380453 0.900662 8.01278178 1.25535559 hsa-miR-574-5p_st 8.055551 0.390453 8.00776417 0.41509893 hsa-let-7d_st 13.8237 0.937665 14.6395953 0.67890386 hsa-miR-576-3p_st 4.835093 0.639694 4.6914083 0.5788278 hsa-miR-576-5p_st 4.09447 0.55129 4.03896274 0.60077985 hsa-miR-577_st 3.433406 0.58579 3.39783603 0.54297977 hsa-miR-578_st 4.279217 0.503452 4.74841374 0.49801171 hsa-miR-579_st 3.512209 0.465282 3.63837976 0.62254428 hsa-miR-580_st 3.389652 0.535233 3.36288777 0.56397498 hsa-miR-191_st 11.95713 1.019289 13.1276483 0.91076401 hsa-miR-582-3p_st 4.134722 0.551934 4.07203176 0.4802804 hsa-miR-582-5p_st 3.651056 0.810482 3.56044359 0.71112644 hsa-miR-1915_st 15.87686 0.67742 15.854516 0.67119738 hsa-let-7c_st 13.82209 1.007105 14.6258993 0.68780309 hsa-miR-585_st 3.888395 0.52089 3.98546492 0.60852002 hsa-miR-586_st 3.259731 0.585465 3.29787831 0.54890185 hsa-miR-324-5p_st 8.345719 0.998362 9.55904048 0.98291148 hsa-miR-588_st 5.356442 0.510705 5.25973662 0.46223529 hsa-miR-589_st 4.826808 0.532217 5.03222025 0.56481849 hsa-miR-589-star_st 5.175403 0.552334 5.02221756 0.461047 hsa-miR-188-5p_st 8.701981 0.570579 8.01556844 0.64230462 hsa-miR-103_st 12.05687 0.974842 13.2364783 0.83619116 hsa-miR-591_st 4.180877 0.502979 4.06804151 0.51249386 hsa-miR-592_st 3.349657 0.451327 3.6368761 0.66362634 hsa-miR-593_st 6.228812 0.589272 5.93167992 0.51808009 hsa-miR-23b_st 13.85558 0.915987 14.8615518 0.83668228 hsa-miR-595_st 7.342816 0.49474 7.03989249 0.5281987 hsa-miR-99a_st 12.11869 1.085738 13.0004023 1.27045265 hsa-miR-15b_st 9.960097 0.966655 11.0795985 1.29203982 hsa-miR-135b_st 3.82595 1.003119 4.96086975 1.44223142 hsa-miR-599_st 3.08883 0.563441 3.20512891 0.5582047 hsa-miR-600_st 6.937915 0.857592 6.88338917 0.89473142 hsa-miR-107_st 11.86548 1.033942 13.0934488 0.90151188 hsa-miR-602_st 14.23869 0.512647 13.7394546 0.54026734 hsa-miR-603_st 2.975714 0.478973 3.10984305 0.52585439 hsa-miR-3065-5p_st 4.189776 0.77206 5.53365472 1.385922 hsa-miR-605_st 5.608277 0.846822 5.58333849 0.67857659 hsa-miR-24_st 12.62531 0.957253 13.9250901 0.90967618 hsa-miR-607_st 3.465717 0.530031 3.67987038 0.60175903 hsa-miR-608_st 9.715185 0.615282 9.23127657 0.66311245 hsa-miR-609_st 3.719508 0.494947 4.03967366 0.47646311 hsa-miR-3196_st 15.87736 0.67809 15.8824716 0.71028462 hsa-miR-26b_st 11.83907 1.259424 13.1464841 1.20134771 hsa-miR-28-5p_st 8.94783 1.023351 10.1279269 1.1313323 hsa-miR-613_st 4.240156 0.550972 4.18330013 0.34438442 hsa-miR-338-3p_st 4.367939 0.827962 5.66948339 1.57862627 hsa-miR-615-3p_st 7.476724 0.670789 7.2177705 0.63536172 hsa-miR-454_st 5.38686 1.208853 7.03521906 1.41553134 hsa-miR-616_st 7.934369 0.601901 7.87628515 0.67416341 hsa-miR-151-5p_st 11.44928 1.008441 12.6499958 0.8956519 hsa-miR-617_st 7.287681 1.02451 6.84066861 0.83430121 hsa-miR-128_st 7.732543 1.189345 9.04873541 1.05143975 hsa-miR-619_st 4.681172 0.34848 4.58496141 0.31563468 hsa-miR-620_st 3.891968 0.486872 3.71820456 0.53975462 hsa-miR-621_st 3.964123 0.440343 4.20913005 0.49817777 hsa-let-7b_st 12.88841 1.132557 13.7900124 0.90138505 hsa-miR-623_st 10.15922 0.570529 9.59605312 0.58480754 hsa-miR-624_st 4.169795 0.448953 4.3762814 0.55822927 hsa-miR-624-star_st 4.283074 0.444894 4.37592611 0.55369432 hsa-miR-183_st 5.896297 1.300923 7.04951101 1.51315999 hsa-miR-30b_st 12.19333 1.11744 13.5169929 1.07723288 hsa-miR-626_st 3.486285 0.412762 3.57027648 0.50105984 hsa-miR-627_st 3.391929 0.476413 3.50703062 0.54436672 hsa-miR-628-3p_st 11.27074 0.681103 10.6728633 1.15733268 hsa-miR-31-star_st 4.231425 1.424487 7.18659167 3.13543855 hsa-miR-218-1-star_st 3.87161 0.593967 3.89083394 0.60424333 hsa-miR-629-star_st 5.548995 0.7401 5.97713246 0.55937671 hsa-miR-630_st 8.696618 0.854998 7.90287743 1.06960098 hsa-miR-631_st 7.499833 0.725022 6.80270554 0.84571171 hsa-miR-632_st 4.641951 0.628312 4.74444294 0.53425603 hsa-miR-633_st 3.319096 0.433817 3.43047285 0.4822794 hsa-miR-634_st 5.909138 1.006653 5.96391768 0.9616405 hsa-miR-635_st 5.380339 0.607 5.25686584 0.609278 hsa-miR-203_st 7.026829 1.674033 8.40698177 1.938087 hsa-miR-331-3p_st 9.604678 1.207767 10.4486235 0.93750986 hsa-miR-125b_st 14.16815 0.956978 15.0986673 0.75828826 hsa-let-7i_st 13.08639 1.115109 14.3904181 0.98969489 hsa-miR-640_st 5.981111 0.645478 5.83314124 0.42916113 hsa-miR-641_st 4.863604 0.67368 4.96635703 0.53444319 hsa-miR-642_st 4.231068 0.374052 4.35733853 0.50423828 hsa-miR-29b_st 11.24211 1.292387 13.0059592 1.27906743 hsa-miR-122_st 5.148438 1.105182 4.66908309 0.45850611 hsa-miR-645_st 4.642508 0.552498 4.52066026 0.38427863 hsa-miR-646_st 3.987533 0.409226 4.11154526 0.4253016 hsa-miR-647_st 5.052799 0.488712 4.99012362 0.43526436 hsa-miR-648_st 9.006868 0.579699 8.37771057 0.57515981 hsa-miR-649_st 4.139383 0.544426 4.24262331 0.5901298 hsa-miR-182_st 8.320659 1.634839 9.80407663 1.36412885 hsa-miR-651_st 3.406728 0.404252 3.37830027 0.51666625 hsa-miR-652_st 7.762146 0.785144 7.66090052 0.90367213 hsa-miR-653_st 3.106265 0.559105 3.28515914 0.61782589 hsa-miR-654-3p_st 4.409858 0.545831 4.69654436 1.06940556 hsa-miR-374b_st 6.784179 1.511822 8.42756078 1.26683136 hsa-miR-130a_st 10.67886 1.109648 12.0938004 1.15952042 hsa-miR-656_st 3.858076 0.518851 3.81634589 0.48296611 hsa-miR-657_st 4.309389 0.504934 4.2909408 0.51396433 hsa-miR-658_st 12.15535 0.595876 11.5767069 0.73000695 hsa-miR-99b_st 10.84881 0.914911 12.0797785 0.89322913 hsa-miR-660_st 7.176118 1.310156 8.24138059 1.07761713 hsa-miR-661_st 7.553739 0.606354 7.00692283 0.69802235 hsa-miR-30e-star_st 9.394527 1.297462 10.4470716 1.29096623 hsa-miR-663_st 15.74623 0.575719 15.5314612 0.55544452 hsa-miR-663b_st 10.56342 0.561011 9.9782248 0.87057747 hsa-miR-664_st 7.247443 1.084276 7.67582306 0.98085867 hsa-miR-664-star_st 10.07695 0.769061 9.73410892 0.76943364 hsa-miR-30d_st 12.15585 1.10351 13.2755269 1.07853256 hsa-miR-668_st 8.535779 0.711298 8.18468539 0.80589631 hsa-miR-670_st 5.602474 0.579955 5.36417669 0.65667168 hsa-miR-671-3p_st 7.096539 0.613408 7.2800469 0.5130224 hsa-miR-671-5p_st 12.48527 0.471147 11.8491822 0.55184124 hsa-miR-30a-star_st 9.913628 1.242736 11.0098384 1.15372118 hsa-miR-675-star_st 5.199538 0.604135 5.00677869 0.5925252 hsa-miR-148b_st 8.623071 1.412245 9.65379722 1.28674343 hsa-miR-708_st 7.497768 1.371632 7.68731642 1.56253808 hsa-miR-708-star_st 4.449526 0.520553 4.45173345 0.47032717 hsa-miR-221-star_st 5.940993 1.523642 8.93721975 2.01740794 hsa-let-7e_st 12.19725 1.072228 13.3554996 0.84428223 hsa-miR-7-1-star_st 5.60317 0.975417 6.69217779 1.01206461 hsa-miR-27b_st 11.72495 1.192107 13.252076 1.25561694 hsa-miR-34a_st 8.818429 1.31172 10.7390344 1.25160145 hsa-miR-744_st 14.60302 0.433249 14.1035807 0.61488927 hsa-miR-744-star_st 4.898123 0.610025 5.2174349 0.58086512 hsa-miR-92b_st 8.744673 0.991824 9.9861944 1.2929912 hsa-miR-759_st 3.383379 0.549334 3.60670846 0.45031657 hsa-miR-760_st 10.52103 0.526829 9.95947682 0.64569263 hsa-miR-92a_st 10.71168 1.073545 12.178659 1.13539102 hsa-miR-335_st 8.231074 1.463711 9.70199242 1.43443428 hsa-miR-96_st 5.672075 1.554382 7.25538985 1.51745738 hsa-miR-95_st 7.520835 1.412527 8.74440166 1.22617304 hsa-miR-766_st 7.460315 0.689031 7.18215676 0.47913116 hsa-miR-767-3p_st 4.410398 0.494527 4.44379549 0.46789476 hsa-miR-767-5p_st 4.344981 0.397539 4.30224829 0.42130275 hsa-miR-98_st 9.330166 1.285238 10.565619 1.05791507 hsa-miR-769-5p_st 6.971213 0.579558 7.37596354 0.64934443 hsa-miR-770-5p_st 7.70514 0.54362 7.59789118 0.49565896 hsa-miR-802_st 3.03639 0.539363 3.03550295 0.62054666 hsa-miR-34b-star_st 5.220218 1.028231 7.22548669 1.42185667 hsa-miR-581_st 3.158983 0.692331 3.14330238 0.73416128 hsa-miR-181d_st 8.660836 0.752218 10.140338 1.09480489 hsa-miR-875-5p_st 3.028981 0.646981 3.05823682 0.71543368 hsa-miR-876-3p_st 3.346264 0.525021 3.20019159 0.55352855 hsa-miR-876-5p_st 2.935535 0.698056 2.88597988 0.71634259 hsa-miR-151-3p_st 8.495696 1.167665 10.1550927 1.03563183 hsa-miR-877-star_st 6.275541 0.65407 5.9610019 0.59463689 hsa-miR-885-3p_st 13.5902 0.664036 13.0211006 0.68358004 hsa-miR-200c_st 13.05241 1.071641 14.154493 0.716178 hsa-miR-429_st 5.263312 1.29015 7.58990141 2.13760823 hsa-miR-886-5p_st 12.66264 0.585452 12.6829797 0.73836371 hsa-miR-224_st 6.426349 1.086518 8.24613982 1.20572049 hsa-miR-888_st 3.56635 0.3945 3.71912215 0.66238961 hsa-miR-4321_st 10.23156 0.60839 9.46000352 0.67790189 hsa-miR-889_st 3.66653 0.391983 3.50288756 0.49165527 hsa-miR-181b_st 9.800986 0.859447 11.4622963 1.08336793 hsa-miR-891a_st 6.678209 0.764227 6.67630315 0.78421623 hsa-miR-891b_st 3.892524 0.462191 4.01530288 0.56083733 hsa-miR-892a_st 4.48396 0.655679 4.36701033 0.78872615 hsa-miR-892b_st 4.607657 0.544555 4.77421859 0.52276112 hsa-miR-9_st 3.134078 0.653622 3.07933128 0.51679944 hsa-miR-222_st 11.22663 1.574958 14.2099299 1.69655332 hsa-miR-141_st 8.911893 1.320621 10.6351303 1.12192034 hsa-miR-221_st 11.30484 1.647249 14.3068888 1.57595605 hsa-miR-924_st 3.920473 0.377516 4.13217675 0.46480255 hsa-miR-181a_st 11.42016 1.036208 13.1392992 1.19855222 hsa-miR-181c_st 8.120238 1.315791 9.88962567 1.30046013 hsa-miR-4324_st 9.881174 1.104873 11.350197 1.29346178 hsa-miR-125a-5p_st 13.23993 1.232642 14.5851589 1.01534821 hsa-miR-92b-star_st 14.88035 0.46156 14.4377746 0.54830917 hsa-miR-3195_st 13.39169 0.575352 12.8077476 0.68159562 hsa-miR-3137_st 11.65405 0.508726 10.8570315 0.71462821 hsa-miR-934_st 5.412581 0.438068 5.39949302 0.53710248 hsa-miR-935_st 4.901166 0.550649 4.92593139 0.63221158 hsa-miR-551b_st 3.885523 0.821241 6.71087698 2.41243655 hsa-miR-937_st 5.57512 0.577337 5.42869087 0.7581966 hsa-miR-938_st 4.939281 0.568237 4.74006421 0.54321864 hsa-miR-939_st 13.47753 0.461945 12.8969978 0.56679539 hsa-miR-7-2-star_st 6.700273 1.641495 5.80045668 1.35019357 hsa-miR-146b-5p_st 8.970762 1.795705 13.8870864 2.49335522 hsa-miR-941_st 6.047517 0.451351 5.96755628 0.5282621 hsa-miR-942_st 3.251245 0.463577 3.41227636 0.50774674 hsa-miR-200a_st 8.98475 1.621996 11.0555869 2.46346642 hsa-miR-944_st 3.507183 0.582631 3.79188423 0.54955929 hsa-miR-7_st 8.560339 2.695633 7.03280562 2.50188996 hsa-miR-375_st 5.421223 0.899364 8.71765043 2.24799369 hsa-miR-96-star_st 4.453053 0.415636 4.41441722 0.51430937 hsa-miR-424_st 7.222357 1.839925 10.0261894 1.72948464 hsa-miR-181a-2-star_st 6.923355 1.163371 9.81057879 1.42816192 hsa-miR-200b_st 10.31959 1.609665 12.3585251 2.10861116 hsa-miR-146b-3p_st 4.555994 0.540995 8.35448682 2.75219474 hsa-miR-99b-star_st 7.760881 0.529145 7.9866775 0.58771086 hsa-miR-9-star_st 4.198891 0.705891 4.13911921 0.6703382 Mean STDEV Mean STDEV Sample Name Hashimoto's Hashimoto's FA FA hsa-miR-150_st 12.59297681 1.493927192 9.680561633 1.976770319 hsa-let-7a-2-star_st 4.368898212 0.58069382 4.476188045 0.624028323 hsa-let-7a-star_st 3.230338439 0.627702949 3.474234511 0.609768215 hsa-miR-513b_st 11.54315174 0.391133362 11.10124324 0.593154903 hsa-let-7b-star_st 7.120969452 0.504473131 7.322926001 0.67786054 hsa-miR-593-star_st 10.13906651 0.609117945 9.502495992 0.811272937 hsa-let-7c-star_st 5.325940555 0.429990487 4.865061648 0.432286831 hsa-miR-516a-5p_st 7.848046402 0.767276008 7.022663975 1.115534602 hsa-miR-142-5p_st 7.968170255 1.615030278 5.172063056 1.912309791 hsa-miR-650_st 11.77476775 0.516748264 10.83037117 0.555237967 hsa-miR-513c_st 8.688858513 0.648213699 8.152700133 0.665420531 hsa-miR-761_st 8.973965633 0.599722764 8.11475894 0.979308734 hsa-let-7f-1-star_st 5.411462812 0.286922672 5.208556663 0.678998313 hsa-miR-513a-5p_st 12.85060904 0.240141221 12.58166042 0.557192603 hsa-miR-654-5p_st 11.68548225 0.595803375 11.33565226 0.835509136 hsa-let-7g-star_st 4.956051648 0.444466323 4.593821717 0.279972564 hsa-miR-3163_st 9.374377934 0.442891376 8.677252722 0.648121653 hsa-let-7i-star_st 6.089701464 0.836709695 5.905784911 0.564078308 hsa-miR-3165_st 8.199654367 0.550486182 7.624753964 1.012249009 hsa-miR-3194_st 11.81088772 0.269349412 11.45806614 0.538496495 hsa-miR-100-star_st 3.089716063 0.451174984 3.386335228 0.333268402 hsa-miR-4251_st 7.398130285 0.477670357 6.948129083 0.561313199 hsa-miR-101-star_st 3.918965924 0.596644495 3.934116088 0.381903628 hsa-miR-922_st 7.070930052 0.523415536 6.187529739 0.559117884 hsa-miR-103-2-star_st 5.687758948 0.525902446 5.269101924 0.857773044 hsa-miR-155_st 11.0042425 1.166970695 9.000990079 1.40128148 hsa-miR-105_st 3.719719058 0.626549171 3.990380659 0.60015099 hsa-miR-127-5p_st 8.252086589 0.527577375 7.602931401 0.876725045 hsa-miR-1286_st 10.13222399 0.400816059 9.626796635 0.519182431 hsa-miR-106a-star_st 3.332232776 0.582368462 3.621524088 0.493800853 hsa-miR-890_st 7.348422194 0.166758269 6.44168761 0.987851216 hsa-miR-3126-5p_st 12.87533671 0.357600541 12.60389554 0.509278546 hsa-miR-489_st 10.45197691 0.358268983 10.20829983 0.353880515 hsa-miR-10a_st 8.085912925 1.183035434 7.96490683 2.131207469 hsa-miR-10a-star_st 5.234263177 0.867654912 4.940245214 1.385190067 hsa-miR-10b_st 9.044114772 1.593743563 8.777033758 1.961390255 hsa-miR-10b-star_st 5.335873445 0.90502076 4.681033937 0.373355805 hsa-miR-1178_st 4.735058152 0.522051214 4.644716321 0.62266766 hsa-miR-1179_st 3.28332617 0.385649074 3.351393736 0.398049605 hsa-miR-1180_st 9.237115409 0.408395509 9.361441797 0.459159701 hsa-miR-1181_st 10.04835518 0.79245699 9.59940679 0.579868118 hsa-miR-3138_st 11.57390612 0.415718555 11.37410469 0.447760147 hsa-miR-220c_st 7.280060012 0.736851631 6.423512263 0.609959868 hsa-miR-510_st 9.614357485 0.509943879 9.126980608 0.527992185 hsa-miR-1185_st 2.888069184 0.677903515 3.057689402 0.550864652 hsa-miR-1193_st 10.55368838 0.316077687 10.44077984 0.305635098 hsa-miR-1197_st 3.414038737 0.282664296 3.788145088 0.494372803 hsa-miR-1200_st 4.700763306 0.447839397 4.491163572 0.364473866 hsa-miR-1201_st 8.25790029 1.392973834 9.18167434 0.918640358 hsa-miR-1202_st 13.66139782 0.434937139 13.8257535 0.362138808 hsa-miR-30c-1-star_st 10.93876915 0.264643927 10.57238492 0.458980139 hsa-miR-1204_st 5.670308344 0.608380222 5.25894626 0.409776133 hsa-miR-1205_st 4.794730246 0.737430368 4.359698996 0.439948585 hsa-miR-1206_st 2.983425706 0.660988291 3.05550405 0.507036239 hsa-miR-1207-3p_st 4.333833764 0.507873147 4.419232999 0.489448114 hsa-miR-1207-5p_st 14.53203489 0.446180629 14.7608213 0.336165461 hsa-miR-1208_st 10.73440982 0.543555646 10.70012897 0.595024775 hsa-miR-622_st 9.800256627 0.350880697 9.152592978 0.434713273 hsa-miR-1224-3p_st 5.732684361 0.474099909 5.509371139 0.617223126 hsa-miR-2116_st 6.931026822 0.786323556 6.194705652 0.726135255 hsa-miR-1225-3p_st 6.636019111 0.578984226 6.318312257 0.748651688 hsa-miR-1225-5p_st 14.37488681 0.386359068 14.59146794 0.374737031 hsa-miR-1226_st 5.998099992 0.834599173 5.791750377 0.592439803 hsa-miR-30b-star_st 9.707559367 0.322239426 9.073672296 0.683000471 hsa-miR-1227_st 4.768560782 0.74350072 4.266449629 0.652925114 hsa-miR-1295_st 7.354523523 0.728007659 6.733871719 0.500940475 hsa-miR-1228-star_st 15.15013328 0.541470856 15.62258357 0.454389481 hsa-miR-20b_st 8.50969933 1.066293132 8.174274658 1.249956355 hsa-miR-122-star_st 3.185233427 0.496339808 3.346739181 0.353847192 hsa-miR-1231_st 14.17961263 0.277523393 14.44552546 0.387514954 hsa-miR-1233_st 6.391984551 0.767675819 6.271968899 0.641260474 hsa-miR-524-5p_st 6.212197532 0.702362811 5.126889059 0.552902226 hsa-miR-1236_st 6.515675705 0.801562509 6.183042057 0.741015432 hsa-miR-873_st 6.073319591 0.634256284 5.172440164 0.549512343 hsa-miR-1238_st 7.765798236 0.412240941 7.450122404 0.776413145 hsa-miR-124_st 9.176328976 0.428233551 8.965378131 0.60788998 hsa-miR-1243_st 4.533701111 0.379086635 4.16677577 0.3364925 hsa-miR-1244_st 8.934190528 0.386619413 8.575725103 0.897634818 hsa-miR-1245_st 4.246888267 0.314342383 4.353102394 0.466647166 hsa-miR-3122_st 12.24711595 0.371340084 12.06888306 0.393510403 hsa-miR-134_st 10.40126373 0.507817346 10.228483 0.466799184 hsa-miR-1248_st 10.55484521 0.993460982 10.70466949 0.709109624 hsa-miR-146a_st 10.60962667 1.413941756 8.811680519 1.362935849 hsa-miR-124-star_st 5.578431866 0.632357573 5.364276181 0.493679723 hsa-miR-1250_st 8.273833152 0.414868258 8.314038506 0.578746121 hsa-miR-764_st 6.37732292 0.665663247 5.59851193 0.66463599 hsa-miR-1252_st 3.035802767 0.338545453 3.305094136 0.464714766 hsa-miR-223_st 10.46963756 1.055806345 8.822220621 1.012539407 hsa-miR-34c-3p_st 8.927813871 0.64812154 8.657939527 0.45247484 hsa-miR-1255a_st 5.882307175 0.890141108 5.238712964 0.615677035 hsa-miR-1255b_st 8.1907117 0.568069492 8.212159462 0.482706522 hsa-miR-1256_st 3.917322672 0.673328424 4.131763266 0.321101775 hsa-miR-1257_st 5.709353364 0.756112862 4.966715253 0.514710387 hsa-miR-199b-5p_st 8.343658774 1.254969683 5.336057707 1.415638547 hsa-miR-1259_st 2.883538272 0.61802562 3.389172524 0.344666748 hsa-miR-492_st 9.659036672 0.43927716 9.285367559 0.712033384 hsa-miR-3132_st 10.07553489 0.472397597 9.563034795 0.515911558 hsa-miR-516b_st 7.669039231 0.558242407 7.184266859 0.649156952 hsa-miR-4294_st 9.35610409 0.51020708 9.163002279 0.418010743 hsa-miR-125b-2-star_st 10.69743717 0.727380836 10.40610237 0.863495011 hsa-miR-126_st 13.19969088 1.096832979 13.94999059 0.91764977 hsa-miR-198_st 12.77634684 0.338633314 12.62223737 0.506933074 hsa-miR-3191_st 12.39681862 0.426328549 12.07068319 0.700461519 hsa-miR-1261_st 8.276447894 0.813656373 7.744511992 0.728778638 hsa-miR-1262_st 4.722918795 0.849045086 4.177070424 0.518414362 hsa-miR-1263_st 4.436536564 0.418040333 4.433252164 0.434659227 hsa-miR-1264_st 3.744398965 0.397266987 3.585860887 0.477493979 hsa-miR-1265_st 5.271184052 0.43816928 5.26475671 0.404006476 hsa-miR-2114-star_st 7.837103552 0.217825136 7.689056246 0.82749395 hsa-miR-1267_st 4.381714412 0.481218707 4.275438504 0.441180782 hsa-miR-1268_st 14.21344156 0.559063317 14.4700937 0.426303104 hsa-miR-1269_st 6.368019696 0.76007708 5.947273708 0.496007227 hsa-miR-509-5p_st 7.00983017 0.586954845 6.439205494 0.735965986 hsa-miR-1270_st 6.602742454 0.367946086 6.595886359 0.555917437 hsa-miR-1271_st 8.043061591 0.407052077 7.694166252 0.456739339 hsa-miR-4303_st 7.625100646 0.543561808 7.022933249 0.582635656 hsa-miR-1273_st 10.30986617 0.529601404 10.29150279 0.413549099 hsa-miR-583_st 8.0530791 0.40470098 7.353675766 0.717208585 hsa-miR-1273d_st 10.73467487 0.723483077 10.69191695 0.43109043 hsa-miR-127-3p_st 6.486647828 1.049403078 5.542823496 0.438654252 hsa-miR-522-star_st 6.871939286 0.60086288 6.39408345 0.604156303 hsa-miR-214-star_st 6.396498347 0.906662458 5.009781595 0.554858801 hsa-miR-184_st 8.797700636 0.389805337 8.496907957 0.754619695 hsa-miR-614_st 7.061998442 0.669870691 6.455119527 0.740154509 hsa-miR-526b_st 6.410725808 0.697094321 5.733628495 0.47375245 hsa-miR-1277_st 3.143089107 0.62005871 3.414935703 0.385892511 hsa-miR-1278_st 3.751734251 0.323889102 3.898132752 0.415359342 hsa-miR-1279_st 3.552121651 0.478014165 3.661172022 0.465986492 hsa-miR-409-3p_st 7.425641825 0.445729154 6.17878187 0.627588767 hsa-miR-199a-5p_st 10.52535891 1.02828183 9.101313876 1.097608807 hsa-miR-1281_st 10.33687103 0.785432718 10.14125631 0.693969679 hsa-miR-1282_st 4.767649378 0.718651091 4.262204616 0.491628748 hsa-miR-33b-star_st 7.949574391 0.341649439 7.476900493 0.380016722 hsa-miR-1284_st 5.704228814 0.927946095 5.182955295 0.64118471 hsa-miR-1253_st 5.812484515 0.554153423 4.909346903 0.585406878 hsa-miR-584_st 8.369329563 0.497670902 8.047552575 0.629095445 hsa-miR-1287_st 6.315226468 0.532265223 6.133798895 0.569991546 hsa-miR-15a_st 9.912067996 1.275736905 9.897536489 0.958282252 hsa-miR-1289_st 4.826260212 0.805293495 4.752716934 0.442162917 hsa-miR-1290_st 10.60530785 0.390803131 10.62808635 0.606253347 hsa-miR-2117_st 4.856708502 0.405835923 4.269146611 0.61583609 hsa-miR-1292_st 12.99625987 0.495604374 12.95641907 0.540677535 hsa-miR-1293_st 7.691813732 0.437475938 7.606666682 0.50661088 hsa-miR-129-3p_st 3.90440647 0.436148719 4.06977514 0.630690643 hsa-miR-520d-5p_st 7.670459263 0.478581168 7.149002313 0.540720904 hsa-miR-526a_st 7.501921285 0.274065712 6.963728794 0.608794781 hsa-miR-129-5p_st 11.76351963 0.587185474 11.90263263 0.468193022 hsa-miR-1254_st 12.41669108 0.52416756 12.18536935 0.534266367 hsa-miR-1297_st 3.138479539 0.681752217 3.336969236 0.426451496 hsa-miR-1298_st 5.482527022 0.815290463 4.8686209 0.615009965 hsa-miR-1299_st 6.116402879 0.800090751 5.908460219 0.75320404 hsa-miR-129-star_st 4.381119254 0.49350199 4.352813039 0.623043894 hsa-miR-1301_st 8.77496205 0.44138579 8.678627805 0.431305149 hsa-miR-19b_st 9.601395956 1.054203825 9.459252981 1.066373738 hsa-miR-1303_st 10.51422819 0.520783595 10.54876598 0.492505832 hsa-miR-1304_st 7.68966199 0.728441986 7.866726186 0.580464672 hsa-miR-1305_st 4.543575033 1.043303288 4.258905443 0.464888554 hsa-miR-550_st 12.55025564 0.320714865 12.3091211 0.486426801 hsa-miR-1307_st 13.74868831 0.518514895 13.92452954 0.513942464 hsa-miR-1308_st 14.87028449 0.432181686 15.30710908 0.613766636 hsa-miR-4291_st 7.783940925 0.237855524 6.998362959 1.068012502 hsa-miR-130a-star_st 4.007375279 0.379362456 3.912156435 0.534217528 hsa-miR-130b_st 8.162425028 0.468649094 7.926300994 0.615463497 hsa-miR-130b-star_st 4.946632361 0.424839466 4.643847022 0.614682309 hsa-miR-921_st 12.24142875 0.445230801 12.058672 0.34431672 hsa-miR-520a-5p_st 5.63576188 0.463917048 4.743103487 0.393471908 hsa-miR-711_st 12.53591279 0.398241208 12.27387907 0.594617387 hsa-miR-1323_st 8.865654215 0.612261565 8.844227472 0.308464882 hsa-miR-1324_st 3.438783323 0.493367472 3.575820473 0.52933928 hsa-miR-490-3p_st 6.806239614 0.624042546 6.100658922 0.489402155 hsa-miR-718_st 9.324827448 0.508420404 8.948201663 0.691448935 hsa-miR-133b_st 5.220598991 0.637760936 5.258255881 0.700576168 hsa-miR-431-star_st 7.109649403 0.251983413 6.590184438 0.530551173 hsa-miR-552_st 6.356368575 0.647654248 6.066952382 0.720277894 hsa-miR-28-3p_st 7.281992787 0.823908522 6.895019688 0.957579816 hsa-miR-4265_st 8.404015205 0.435495126 8.32715757 0.508674201 hsa-miR-643_st 4.779738854 0.426969475 4.201678651 0.743058953 hsa-miR-136_st 2.890184532 0.558213862 3.162133428 0.457575376 hsa-miR-136-star_st 3.216338341 0.496628876 3.417351586 0.391138828 hsa-miR-137_st 3.220344459 0.416991633 3.634790107 0.363085743 hsa-miR-138_st 9.51379606 1.086567709 10.67195657 0.800093316 hsa-miR-138-1-star_st 8.489513565 0.538260572 8.588418344 0.482949732 hsa-miR-138-2-star_st 5.190108811 0.249678662 5.332668728 0.520164192 hsa-miR-139-3p_st 8.322152123 0.594265758 8.01035086 0.641212816 hsa-miR-139-5p_st 7.037960775 1.448294822 8.209362372 0.78676886 hsa-miR-140-3p_st 11.01194322 0.563139461 10.73342944 0.569273694 hsa-miR-140-5p_st 6.395775207 1.321575874 5.945129065 0.866211636 hsa-miR-381_st 7.04502034 0.625356042 6.231692308 0.555481808 hsa-miR-141-star_st 3.733303263 0.509729428 3.812289122 0.444263688 hsa-miR-17-star_st 6.448350563 0.572822677 5.805072541 0.537873209 hsa-miR-4300_st 8.613800226 0.466243937 7.958352121 0.680555144 hsa-miR-143_st 11.80029015 1.088424797 12.27332708 0.943395752 hsa-miR-143-star_st 5.979569854 0.808577228 6.684964249 0.807284112 hsa-miR-144_st 3.13603898 0.470668665 3.411842382 0.413331828 hsa-miR-3198_st 10.42228431 0.273030853 10.20121318 0.437168827 hsa-miR-145_st 12.34424801 1.08868289 13.19838962 0.712228298 hsa-miR-145-star_st 5.413067017 0.960988521 5.679842498 1.341225225 hsa-miR-1468_st 6.181761372 0.978342561 6.010161668 0.852322405 hsa-miR-1469_st 15.29018598 0.572766323 15.98482591 0.454211488 hsa-miR-1973_st 15.0382681 0.579746007 15.49123238 0.600947367 hsa-miR-3154_st 12.02055305 0.452014401 11.73806747 0.278056041 hsa-miR-148a-star_st 6.23799973 0.4016161 5.541215715 0.652361835 hsa-miR-92a-1-star_st 8.570503065 0.578042905 8.159637583 0.337849176 hsa-miR-147_st 4.284393717 0.452499164 4.270340607 0.389067898 hsa-miR-194-star_st 9.159880339 0.598652563 8.832984032 0.632600779 hsa-miR-1471_st 11.3878725 0.859950302 11.1255924 0.525165298 hsa-miR-147b_st 4.85865749 0.387316736 4.517759129 0.453339436 hsa-miR-148a_st 10.97158612 0.949944088 11.63704493 1.024027428 hsa-miR-4299_st 13.81659249 0.248550142 13.91344208 0.446050473 hsa-miR-135a-star_st 13.50517178 0.516465855 13.3464063 0.420961133 hsa-miR-612_st 12.41954996 0.525182181 12.07050245 0.48592747 hsa-miR-1321_st 8.092763529 0.419292019 7.69663273 0.495139777 hsa-miR-149-star_st 15.28597629 0.573333644 15.91547129 0.414391933 hsa-miR-604_st 9.778796173 0.295523916 9.682478741 0.402774636 hsa-miR-150-star_st 14.22966314 0.379879756 14.42183934 0.392074932 hsa-miR-125b-1-star_st 12.30506459 0.398136879 11.94795678 0.562528852 hsa-miR-1183_st 10.63456706 0.31879299 10.43869103 0.314652122 hsa-miR-152_st 9.348215417 1.234769248 10.42296212 0.911316914 hsa-miR-153_st 3.431151403 0.464262852 3.776103249 0.473040479 hsa-miR-1537_st 3.365761206 0.511408159 3.446122447 0.529613126 hsa-miR-1538_st 7.883596862 0.343325953 8.077112647 0.562697067 hsa-miR-1539_st 5.821310732 0.528544205 5.7348157 0.37639766 hsa-miR-154_st 5.017602473 0.764620653 4.645635018 0.545623289 hsa-miR-154-star_st 5.468651709 0.779266185 4.614946983 0.566617555 hsa-miR-432-star_st 5.631413585 0.724099146 4.706952649 0.50121821 hsa-miR-155-star_st 3.2518343 0.450096824 3.697576216 0.332710499 hsa-miR-298_st 11.27096321 0.42345003 10.99572539 0.447493668 hsa-miR-15a-star_st 5.25478601 0.862019686 5.026365894 0.809239072 hsa-miR-2110_st 11.39380778 0.289813785 11.19069899 0.740794188 hsa-miR-15b-star_st 3.890166979 0.744161027 3.74929862 0.622325845 hsa-miR-1266_st 9.96625722 0.457454288 9.764862447 0.498449287 hsa-miR-16-1-star_st 4.636567414 0.394399293 4.616639694 0.361503493 hsa-miR-16-2-star_st 4.774362535 0.709804814 4.801322524 0.481349881 hsa-miR-490-5p_st 8.045061147 0.472448416 7.759574176 0.487181889 hsa-miR-19a_st 5.940003581 1.207340569 5.591131621 0.923369463 hsa-miR-3192_st 9.388884824 0.377543385 9.111902073 0.448730631 hsa-miR-3155_st 8.413696078 0.338867414 7.837110229 0.427101101 hsa-miR-187-star_st 11.36303714 0.382765003 11.36127305 0.348406872 hsa-miR-16_st 13.17782644 0.856276508 13.13051481 0.675319087 hsa-miR-936_st 11.41059269 0.56058769 11.11624365 0.255196152 hsa-miR-181c-star_st 7.663847447 0.460229201 7.458598744 0.569050369 hsa-miR-379_st 6.562358207 0.310458882 5.72442109 0.613897801 hsa-miR-370_st 11.53487494 0.541065532 11.58933444 0.466867693 hsa-miR-541_st 9.007309072 0.363139935 8.791512743 0.503092957 hsa-miR-518c-star_st 9.00865515 0.491677011 8.70984069 0.374279069 hsa-miR-487b_st 8.844536782 1.085199516 8.959238316 0.906423418 hsa-miR-182-star_st 3.274267497 0.403099836 3.526936776 0.285724948 hsa-miR-3121_st 8.403770303 0.511260865 8.192220607 0.635880412 hsa-miR-3190-5p_st 10.64526171 0.29222142 10.48540666 0.435911062 hsa-miR-1203_st 9.455249589 0.352757008 9.275954018 0.403888763 hsa-miR-185_st 9.377498703 0.46565094 9.36294786 0.703206029 hsa-miR-185-star_st 9.731613461 0.486840207 9.548973138 0.64453104 hsa-miR-4317_st 10.39929652 0.383841285 10.22601623 0.539247807 hsa-miR-186-star_st 3.167456881 0.525039539 3.104754006 0.553441475 hsa-miR-187_st 5.855320542 0.555911803 5.303844034 0.891042561 hsa-miR-4257_st 12.76496141 0.479207718 12.75927404 0.332969343 hsa-miR-188-3p_st 5.026897235 0.739539037 4.61630837 0.521490701 hsa-miR-1184_st 5.813593337 0.503516567 5.176397611 0.58494121 hsa-miR-18a_st 5.058342252 0.330475665 4.607061934 0.759798443 hsa-miR-18a-star_st 5.57821253 0.75759913 5.226058381 0.64242214 hsa-miR-3140_st 5.971973814 0.655518682 5.047745257 0.438290744 hsa-miR-18b-star_st 4.695490903 0.738311834 4.385397265 0.256041553 hsa-miR-190_st 2.640697035 0.532441154 3.112156432 0.727952426 hsa-miR-601_st 6.638540853 0.325898542 6.528271706 0.851792055 hsa-miR-1909_st 14.69273882 0.346627258 14.75048598 0.451076953 hsa-miR-342-5p_st 6.359989959 0.74141318 5.388330858 0.760959902 hsa-miR-575_st 13.76414259 0.3448865 13.9405819 0.455774818 hsa-miR-885-5p_st 7.305481855 0.170038563 7.048830458 0.746833837 hsa-miR-300_st 6.362645721 0.449742117 5.970357 0.59994688 hsa-miR-1911_st 4.600373861 0.802898143 4.193433417 0.414958019 hsa-miR-1911-star_st 6.047802634 0.484632737 5.380550732 0.722980269 hsa-miR-1912_st 4.903858015 0.494711455 4.624507585 0.45181846 hsa-miR-4266_st 7.203928071 0.204192164 6.719455231 0.650740081 hsa-miR-1914_st 6.003719432 0.525418265 5.841247451 0.596677388 hsa-miR-3190-3p_st 11.22712183 0.351888979 11.28009251 0.316823907 hsa-miR-618_st 4.550836067 0.476917075 3.941733546 0.326032533 hsa-miR-1276_st 7.63194633 0.495361224 7.348842284 0.649327547 hsa-miR-191-star_st 7.025457938 0.581820547 6.783103247 0.851047438 hsa-miR-1258_st 5.612272209 0.323717986 5.135981625 0.504250726 hsa-miR-192-star_st 3.84201051 0.462954871 4.011675706 0.501862631 hsa-miR-193a-3p_st 7.568963535 0.622273055 7.642839137 1.301010916 hsa-miR-193a-5p_st 12.72807685 0.337471845 12.98096904 0.385582348 hsa-miR-3157_st 5.759137402 0.437829308 5.330767541 0.273398309 hsa-miR-193b-star_st 11.29302541 0.41887514 11.20686901 0.402420576 hsa-miR-194_st 6.651991732 1.530259222 7.170005188 1.231659284 hsa-miR-4307_st 4.457446636 0.401460385 3.776068137 0.508536222 hsa-miR-195_st 10.85557618 0.789325673 11.64324192 0.845762285 hsa-miR-610_st 6.343888877 0.451680787 5.688924457 0.521109134 hsa-miR-196a_st 4.660586118 0.988345407 4.669550936 0.703856682 hsa-miR-196a-star_st 5.984980565 0.668019133 6.435395573 0.850318501 hsa-miR-196b_st 3.786350854 0.357301044 4.194671926 0.486403292 hsa-miR-196b-star_st 6.107369945 0.296279163 5.892434246 0.499977315 hsa-let-7f-2-star_st 4.325184829 0.434691288 3.694520537 0.392398101 hsa-miR-1972_st 12.60833799 0.658594338 12.58168553 0.512639748 hsa-miR-3184_st 10.59061984 0.335389535 10.29022648 0.592093543 hsa-miR-523-star_st 6.769203429 0.380203317 6.494685715 0.731056707 hsa-miR-1976_st 7.350990606 0.736126706 7.011195428 0.791236192 hsa-miR-625-star_st 5.070569401 0.232981354 4.356170861 0.510997662 hsa-miR-587_st 5.307002914 0.430236466 5.078528663 0.450415921 hsa-miR-199a-3p_st 11.68120935 1.06998233 10.4840672 0.927152967 hsa-miR-1910_st 9.269185002 0.474996479 8.881228569 0.317932991 hsa-miR-199b-3p_st 11.53994739 1.122112158 10.712705 0.829555674 hsa-miR-639_st 9.378550407 0.496927687 9.187536885 0.955381778 hsa-miR-1909-star_st 9.235986566 0.09537851 8.7244257 0.489301447 hsa-miR-19a-star_st 2.976220386 0.493263466 3.303514396 0.63058184 hsa-miR-29c-star_st 6.853146715 1.469213543 7.740637686 0.688003874 hsa-miR-940_st 9.212092664 0.474834334 8.917964765 0.488480576 hsa-miR-19b-2-star_st 3.059814007 0.341694828 3.005228387 0.581801252 hsa-miR-4269_st 8.981503238 0.344938129 8.616971493 0.527530453 hsa-miR-200a-star_st 6.916820447 0.463657355 6.638609214 0.677381499 hsa-miR-1182_st 10.77634451 0.371307879 10.66976935 0.325362897 hsa-miR-518f-star_st 7.287741756 0.138252405 6.83490537 0.543979698 hsa-miR-92a-2-star_st 9.405290013 0.301702649 9.179324331 0.569641345 hsa-miR-200c-star_st 4.208917552 0.686741366 4.405990797 0.674489036 hsa-miR-202_st 9.627548021 0.746984887 9.31472474 0.427059353 hsa-miR-202-star_st 2.578214413 0.607423663 3.093716672 0.448813034 hsa-miR-1914-star_st 13.51365221 0.293210118 13.43599804 0.540965097 hsa-miR-204_st 6.545023442 2.308105147 8.176927693 2.488648826 hsa-miR-665_st 13.24658039 0.292473067 12.95615237 0.430695782 hsa-miR-2052_st 2.760075146 0.555404176 3.1531863 0.699163894 hsa-miR-2053_st 3.346415614 0.671853663 3.718443561 0.515446155 hsa-miR-2054_st 2.354724102 1.044023463 2.917363703 0.852013343 hsa-miR-205-star_st 5.505860754 0.611554474 5.494065975 0.725187215 hsa-miR-206_st 6.814145472 0.513806714 6.197200523 0.48880875 hsa-miR-208a_st 3.903928092 0.276030838 3.989947251 0.738610505 hsa-miR-208b_st 3.926105847 0.306093544 4.01584638 0.718944553 hsa-miR-18b_st 4.668858511 0.28665112 4.165489246 0.338448889 hsa-miR-20a-star_st 4.443416371 1.376381674 4.145007003 0.492730964 hsa-miR-3181_st 8.974298368 0.231934232 8.872343368 0.490970641 hsa-miR-615-5p_st 11.56240824 0.268978302 11.15840105 0.696950903 hsa-miR-4259_st 11.15870007 0.450103014 11.07611358 0.429458326 hsa-miR-210_st 12.94487154 0.508229734 13.03031693 0.434108253 hsa-miR-211_st 5.407777645 0.845988511 5.20158111 0.64253476 hsa-miR-887_st 9.765599704 0.42698835 9.449489036 0.426397089 hsa-miR-2113_st 5.801335877 0.835950895 5.041057024 0.761862192 hsa-miR-2114_st 4.696035322 0.796251249 4.176838826 0.346821758 hsa-miR-943_st 7.694423938 0.452350592 7.641173266 0.760082538 hsa-miR-2115_st 3.201588126 0.418695884 3.329121811 0.495899106 hsa-miR-2115-star_st 10.48023923 0.634753156 11.04554668 1.009084519 hsa-miR-183-star_st 7.818580682 0.318013874 7.619040909 0.596060563 hsa-miR-2116-star_st 4.723772704 0.313965102 4.241287031 0.881558633 hsa-miR-920_st 10.74457322 0.369714646 10.58578481 0.643697709 hsa-miR-212_st 6.705874851 0.334308619 6.271027126 0.530595347 hsa-miR-214_st 11.02630929 0.509666041 10.57168393 0.504975226 hsa-miR-1825_st 7.410962651 0.436920996 6.839384674 0.696972939 hsa-miR-215_st 6.422174142 0.790867758 5.741971851 0.950378666 hsa-miR-216a_st 3.863135597 0.605866789 3.883299785 0.374058359 hsa-miR-195-star_st 6.165872399 0.427606025 5.607956309 0.748938875 hsa-miR-217_st 3.214248113 0.368647406 3.450278032 0.335836861 hsa-miR-23a-star_st 11.20395014 0.449235222 11.06230496 0.502263536 hsa-miR-25-star_st 12.96805596 0.273925721 12.8288534 0.499957547 hsa-miR-218-2-star_st 4.628488181 0.410017353 4.331783998 0.446951497 hsa-miR-1273c_st 11.12970939 0.059694025 11.05626111 0.42259596 hsa-miR-219-2-3p_st 7.386043654 0.459281434 7.218193955 0.506772461 hsa-miR-637_st 12.2380645 0.37534016 12.1878469 0.511503359 hsa-miR-21-star_st 7.295021846 0.413761578 6.600574263 0.904685023 hsa-miR-22_st 10.91315927 1.292068644 12.0285146 0.923234886 hsa-miR-220a_st 3.326423436 0.499844818 3.423820136 0.464684183 hsa-miR-220b_st 3.924414178 0.822393298 3.88892985 0.336400611 hsa-miR-219-1-3p_st 6.120407172 0.33281665 5.704502402 0.403114258 hsa-miR-4316_st 7.849336193 0.384567978 7.736813109 0.551657609 hsa-miR-877_st 12.60870085 0.370165904 12.63107819 0.38536824 hsa-miR-636_st 7.965892976 0.184383766 7.825257039 0.691251909 hsa-miR-3177_st 12.27032888 0.438373728 12.26541939 0.539604174 hsa-miR-1249_st 5.462245426 0.30738947 4.949882595 0.6268105 hsa-miR-223-star_st 4.500080107 0.449587235 4.102742036 0.480348152 hsa-miR-1224-5p_st 13.73200803 0.363227423 13.81215448 0.213992569 hsa-miR-564_st 12.58505158 0.331378659 12.55010663 0.391707845 hsa-miR-2276_st 11.63683935 0.550169646 11.68901578 0.5330301 hsa-miR-2277_st 7.450432673 0.092822088 7.397569279 0.609053951 hsa-miR-2278_st 6.595480614 0.618968643 6.424664461 0.621708168 hsa-miR-22-star_st 6.843601838 1.452299576 8.270075581 1.070902988 hsa-miR-2355_st 4.64994947 0.667242155 4.153860831 0.475868392 hsa-miR-769-3p_st 9.811633221 0.340092065 9.448050583 0.508736112 hsa-miR-1913_st 8.08372926 0.323769725 7.721164302 0.509474388 hsa-miR-1237_st 7.697861326 0.277147366 7.346392781 0.524149581 hsa-miR-1275_st 13.85026207 0.293408242 13.79885195 0.355554775 hsa-miR-30a_st 11.66306692 1.333084928 12.57025379 0.669974915 hsa-miR-20b-star_st 6.187310909 0.203685582 5.990653449 0.543675506 hsa-miR-24-2-star_st 6.969663452 0.79206723 6.037840766 0.803139343 hsa-miR-3173_st 10.144865 0.24151213 10.0414114 0.41142212 hsa-miR-3148_st 5.938334859 0.313997028 5.68622722 0.598628803 hsa-miR-4271_st 12.73686094 0.306387833 12.88325576 0.200970738 hsa-miR-659_st 11.06023921 0.377207571 10.94202916 0.43258648 hsa-miR-26a-2-star_st 2.50902779 0.562748283 3.071132329 0.718697485 hsa-miR-1228_st 7.485638214 0.225204381 7.095711605 0.732006376 hsa-miR-26b-star_st 5.222182122 0.762304372 5.417197762 0.583852434 hsa-miR-3174_st 7.802803437 0.336549564 7.686101753 0.711722026 hsa-miR-27a-star_st 6.264972807 0.838568284 5.442168851 0.461898557 hsa-miR-1285_st 13.00598097 0.338693999 12.87188152 0.314517442 hsa-miR-483-5p_st 12.18239486 0.30638993 12.10051282 0.249688589 hsa-miR-1306_st 7.321087756 0.300005004 7.180460859 0.458141661 hsa-miR-431_st 4.374879212 0.214524022 3.987032986 0.392380707 hsa-miR-765_st 9.475196781 0.27331103 9.268111222 0.36723301 hsa-miR-2909_st 3.816773155 0.378183045 4.097995858 0.415540151 hsa-miR-296-3p_st 11.55649972 0.605449361 11.48000471 0.375333936 hsa-miR-296-5p_st 4.919553775 0.705856868 4.441437937 0.48574802 hsa-miR-297_st 5.659283477 0.559042855 5.316389436 0.68730864 hsa-miR-323b-5p_st 7.899009606 0.325763596 7.590828184 0.70969393 hsa-miR-299-3p_st 7.91068893 0.637259974 7.306640606 0.810793024 hsa-miR-299-5p_st 3.940575681 0.335669601 4.101872632 0.344268233 hsa-miR-487a_st 5.987019981 0.69742572 5.738385626 0.727555371 hsa-miR-29a-star_st 3.56493965 0.231192424 3.592211235 0.67208154 hsa-miR-625_st 7.634657094 0.173404529 6.838309084 0.427354793 hsa-miR-611_st 8.518541752 0.300012308 8.101312402 0.786451505 hsa-miR-3186-3p_st 9.243000141 0.3015793 8.858347367 0.592675032 hsa-miR-1294_st 6.1706879 0.134830064 5.765477705 0.498227506 hsa-miR-3147_st 10.7830605 0.333592962 10.82864992 0.400846036 hsa-miR-4285_st 11.75144695 0.137368992 11.75567428 0.684749329 hsa-miR-125a-3p_st 12.00569563 0.360055672 11.81496195 0.39624021 hsa-miR-301b_st 3.259983602 0.450638397 3.439428324 0.557724067 hsa-miR-302a_st 3.368846232 0.478968678 3.477564279 0.613201997 hsa-miR-518e-star_st 6.970699489 0.404168862 6.504477272 0.577117365 hsa-miR-302b_st 2.597282043 0.919406479 3.230136027 0.629390845 hsa-miR-302b-star_st 4.215388458 0.267642731 4.483982668 0.375640697 hsa-miR-302c_st 3.230956033 0.564849903 2.979927799 0.410501244 hsa-miR-302c-star_st 9.053419999 0.481100529 9.249888538 0.490524816 hsa-miR-302d_st 3.175695033 0.467019518 3.321578983 0.407216318 hsa-miR-302d-star_st 8.631883853 0.323235615 9.045044258 0.92045216 hsa-miR-302e_st 3.816638698 0.606233875 3.583729011 0.555188943 hsa-miR-302f_st 3.148323675 0.332905323 3.441831968 0.476211155 hsa-miR-3065-3p_st 5.761935044 0.985723987 5.105828157 0.473042377 hsa-miR-3130-5p_st 7.471005902 0.208931189 7.489599573 0.594629894 hsa-miR-3074_st 5.441927309 0.499434479 5.317937234 0.571963105 hsa-miR-1226-star_st 11.98645622 0.248957447 11.99819789 0.477014517 hsa-miR-3180-5p_st 7.032591818 0.195015496 7.000051832 0.512388455 hsa-miR-1229_st 7.132909193 0.430107361 7.018577284 0.410224107 hsa-miR-1272_st 4.878169992 0.276113535 4.509970111 0.462687047 hsa-miR-30c_st 12.5672631 1.292946599 13.94021513 0.52999949 hsa-miR-675_st 13.6063338 0.302432994 13.4965141 0.542711393 hsa-miR-30c-2-star_st 7.668069071 0.630449366 7.263663226 0.665588994 hsa-miR-1827_st 4.649087415 0.44266365 4.414640605 0.40455572 hsa-miR-30d-star_st 3.648343129 0.696573446 3.728423108 0.513629088 hsa-miR-30e_st 9.307704733 1.26066379 10.14849389 0.992619798 hsa-miR-1915-star_st 7.434364284 0.243492889 7.030711072 0.731973496 hsa-miR-1322_st 4.691025546 0.234154911 4.311379098 0.371918202 hsa-miR-3115_st 3.552953812 0.62131637 3.543149629 0.373326216 hsa-miR-3116_st 7.580046647 0.871614745 7.143605467 0.521457719 hsa-miR-3117_st 4.701389042 0.446000686 4.65215389 0.383879527 hsa-miR-3118_st 3.455323211 0.552114285 3.831231964 0.417708026 hsa-miR-519b-5p_st 6.386126474 0.318796048 6.08869309 0.542952942 hsa-miR-3120_st 7.095836313 0.794855416 6.724013822 0.451479382 hsa-miR-520d-3p_st 5.752904031 0.248336318 5.558840417 0.549552874 hsa-miR-326_st 6.176684958 0.718141814 5.824990481 0.32232359 hsa-miR-3123_st 2.823050653 0.627208915 3.011666614 0.708174529 hsa-miR-3124_st 12.56615148 0.345904585 12.47282686 0.49829628 hsa-miR-3125_st 7.944418984 0.383849872 7.55203057 0.765066912 hsa-miR-3126-3p_st 4.920841204 0.57823121 4.892667168 0.519594591 hsa-miR-1296_st 7.163665411 0.275273924 6.71151592 0.591026522 hsa-miR-3127_st 9.45291955 0.728597094 9.479477745 0.354084814 hsa-miR-3128_st 4.089988171 0.239894206 4.192276261 0.385750184 hsa-miR-3129_st 4.37913296 0.291774651 4.281724146 0.391177044 hsa-miR-3130-3p_st 9.163500897 0.606641183 8.862886485 0.469689533 hsa-miR-105-star_st 4.306047532 0.276473487 3.927099582 0.47288221 hsa-miR-3131_st 12.15605251 0.498658861 11.9589446 0.432296015 hsa-miR-4255_st 4.485985221 0.170317023 4.114825097 0.356452809 hsa-miR-3133_st 4.303866677 0.586581086 4.925889371 1.784977189 hsa-miR-3134_st 3.896287544 0.384436651 3.575803099 0.608940554 hsa-miR-3135_st 6.997822745 0.804121787 6.807215094 0.471767523 hsa-miR-3136_st 6.292801128 0.511485657 6.392019402 0.458735583 hsa-miR-19b-1-star_st 3.943443878 0.347183576 3.959147049 0.32500859 hsa-miR-1247_st 7.255813785 0.235726318 7.124789375 0.65019808 hsa-miR-3139_st 4.076816362 0.24161553 3.90671338 0.354161945 hsa-miR-596_st 6.728786675 0.131994596 6.425032448 0.486581407 hsa-miR-3141_st 14.31298038 0.430497846 14.53239362 0.422062213 hsa-miR-3142_st 2.893773803 0.693809741 3.285104865 0.440907613 hsa-miR-1302_st 3.581719298 0.36091295 3.810408542 0.236689367 hsa-miR-3144-3p_st 4.971301717 1.000198783 4.372462998 0.400731356 hsa-miR-3144-5p_st 6.025695932 1.051816445 5.189687362 0.369714383 hsa-miR-3145_st 3.428459876 0.732751368 3.489102691 0.61173327 hsa-miR-3146_st 4.920849838 0.63733804 4.804815077 0.447846595 hsa-miR-346_st 8.546477279 0.197421063 8.478721929 0.517790544 hsa-miR-4256_st 4.308171864 0.248339018 4.090035948 0.365676689 hsa-miR-3149_st 4.932551145 0.57281601 4.587341072 0.593502683 hsa-miR-3150_st 9.974437455 0.516556671 9.718009019 0.482252317 hsa-miR-3151_st 11.78569845 0.372343445 11.7102942 0.458831102 hsa-miR-1470_st 5.831666096 0.210671054 5.518516658 0.434967592 hsa-miR-3153_st 9.76080699 0.562439606 9.438487878 0.562261459 hsa-miR-514_st 3.080612728 0.201089517 3.451818868 0.383807564 hsa-miR-3175_st 12.87838752 0.102131539 13.11896015 0.280641082 hsa-miR-3156_st 10.57231291 0.361051687 10.4790666 0.433171319 hsa-miR-504_st 5.369207788 0.254472427 5.643876196 0.654856859 hsa-miR-3158_st 5.199532384 0.638158246 4.862517098 0.792679554 hsa-miR-3159_st 5.35454995 0.520929429 4.996293774 0.413051303 hsa-miR-3160_st 6.329029618 0.578825127 5.928122471 0.65772148 hsa-miR-3161_st 8.078330917 0.393578397 8.028612812 0.70304002 hsa-miR-3162_st 13.61129537 0.382647617 13.74016591 0.281567056 hsa-miR-1234_st 7.430496844 0.24346812 7.804084768 0.341248964 hsa-miR-3164_st 8.280812703 0.865735498 7.767042678 0.456826565 hsa-miR-516b-star_st 3.687851166 0.236473182 3.940822171 0.543666218 hsa-miR-3166_st 4.678145587 0.541500516 4.805545909 0.446833234 hsa-miR-4327_st 12.74712647 0.402828131 12.92894737 0.355793001 hsa-miR-3168_st 3.140494166 0.36004325 3.27220798 0.534956773 hsa-miR-3169_st 4.75153724 0.309753014 4.616880149 0.571050774 hsa-miR-3170_st 7.187293277 0.589324576 6.67695758 0.597061822 hsa-miR-3171_st 3.231063903 0.475030581 3.637849204 0.347724364 hsa-miR-3172_st 14.58285831 0.734537339 15.41871443 0.763529026 hsa-miR-374b-star_st 3.605525421 0.272833897 3.818550782 0.193224732 hsa-miR-34c-5p_st 3.945093199 0.261896137 4.136344236 0.309643599 hsa-miR-758_st 3.234208461 0.329757099 3.792955448 0.454477117 hsa-miR-3176_st 11.51930491 0.445282637 11.65911602 0.438608334 hsa-miR-606_st 2.954713825 0.186894213 3.228249322 0.510867262 hsa-miR-3178_st 15.17192555 0.549934826 15.51887145 0.507361375 hsa-miR-3179_st 4.588186265 1.035317464 4.467336367 0.693758702 hsa-miR-3180-3p_st 14.44952559 0.392112236 14.64098154 0.45564938 hsa-miR-597_st 3.149339096 0.221305103 3.359079574 0.299809355 hsa-miR-148b-star_st 3.157023161 0.103831491 3.29534718 0.394187076 hsa-miR-3182_st 4.213787575 0.639297041 4.131789963 0.391402982 hsa-miR-3183_st 6.227052298 0.499115078 6.114589632 0.701330752 hsa-miR-144-star_st 3.489085506 0.337877935 3.955255478 0.374795219 hsa-miR-3185_st 14.87958507 0.48906285 15.23627387 0.493389999 hsa-miR-4270_st 15.01088289 0.549871585 15.41615148 0.378861452 hsa-miR-3186-5p_st 5.821172624 0.760935079 5.549492043 0.402767751 hsa-miR-3187_st 13.29828434 0.406092356 13.41204636 0.457200818 hsa-miR-3188_st 13.77097499 0.488316812 14.01067639 0.407855668 hsa-miR-3189_st 8.05952106 0.689246615 7.673060932 0.504908616 hsa-miR-548b-3p_st 3.364265581 0.423719651 3.730346207 0.523724925 hsa-miR-99a-star_st 4.762006882 0.366698021 5.07411644 0.711002596 hsa-miR-376a-star_st 2.508795248 0.413876151 3.141246692 0.522671865 hsa-miR-216b_st 3.593037614 0.443346073 3.731855827 0.317200087 hsa-miR-3193_st 7.021865923 0.471895494 7.103500797 0.370434753 hsa-miR-548v_st 2.845068859 0.205041887 3.396418556 0.508541998 hsa-miR-26a-1-star_st 3.573250018 0.574812573 3.691151571 0.364309414 hsa-miR-1291_st 8.889656447 0.402786491 9.530605779 0.4661868 hsa-miR-3197_st 15.08746937 0.490299136 15.3427786 0.481987336 hsa-miR-629_st 7.705268389 0.300513199 7.533290481 0.590257946 hsa-miR-3199_st 5.728620002 0.515684189 5.530124897 0.530147228 hsa-miR-190b_st 2.609491809 0.249716498 3.237094422 0.355862875 hsa-miR-32_st 2.765905493 0.725766961 3.332213769 0.474489246 hsa-miR-3200_st 4.050219102 0.67131976 4.294935738 0.502940386 hsa-miR-3201_st 4.231262337 0.564257918 4.164140932 0.444900893 hsa-miR-3202_st 8.352925569 0.584868291 7.687301107 0.890924001 hsa-miR-320a_st 12.08249638 0.448833517 12.22087357 0.328277944 hsa-miR-4289_st 6.454167493 0.331477325 6.602280966 0.764782683 hsa-miR-655_st 2.684284953 0.424472471 3.089853494 0.631801198 hsa-miR-320b_st 10.9903144 0.204944235 11.19330749 0.376207817 hsa-miR-219-5p_st 2.742751789 0.415606475 3.340970919 0.685333818 hsa-miR-323-3p_st 4.496084213 0.275252466 4.406669614 0.555964999 hsa-miR-323-5p_st 11.08988762 0.561962492 11.10042896 0.763650438 hsa-miR-323b-3p_st 4.053537932 0.325737681 3.878949006 0.275697756 hsa-miR-103-as_st 3.699003147 0.234688546 4.115786955 0.301352484 hsa-miR-424-star_st 8.403914726 0.285606249 8.718096087 0.412283857 hsa-miR-33a-star_st 3.854974817 0.511255348 4.024523327 0.574469735 hsa-miR-325_st 5.096289688 0.539990458 4.923856584 0.648216164 hsa-miR-590-3p_st 2.908542911 0.520373044 3.378046505 0.519922219 hsa-miR-328_st 7.180185463 1.013616002 7.877897664 0.406027747 hsa-miR-329_st 4.138801731 0.716059657 3.708660036 0.353852712 hsa-miR-32-star_st 5.22691562 0.50880596 4.873028306 0.496570821 hsa-miR-330-3p_st 6.980399875 0.468357306 6.496837719 0.441196587 hsa-miR-330-5p_st 6.292974199 0.499851427 6.061895164 0.61460993 hsa-miR-146a-star_st 2.816475154 0.431718623 3.265816697 0.487030193 hsa-miR-331-5p_st 7.250211775 0.341458026 7.23226449 0.623240916 hsa-miR-3167_st 3.166391574 0.439408415 3.431822699 0.403014968 hsa-miR-335-star_st 4.317069956 0.684479857 4.211945196 0.793779177 hsa-miR-337-3p_st 4.978977748 0.976514438 4.421475435 0.672586477 hsa-miR-337-5p_st 4.096343579 0.472160758 3.723175748 0.301297161 hsa-miR-421_st 7.080391892 0.247684602 7.001604689 0.826111817 hsa-miR-338-5p_st 5.675320906 0.469608971 5.495045334 0.443624659 hsa-miR-339-3p_st 8.793336444 0.617385745 9.042854645 0.550001936 hsa-miR-548a-5p_st 4.067775729 0.289196833 4.565884157 0.359161266 hsa-miR-33a_st 2.76307636 0.655458502 3.185567803 0.494838441 hsa-miR-590-5p_st 3.312423448 0.470595048 3.621515964 0.431059799 hsa-miR-33b_st 3.108084971 0.725169784 3.473219948 0.335862482 hsa-miR-616-star_st 3.606718749 0.274095786 4.165351778 0.651495724 hsa-miR-569_st 3.526240331 0.459295113 3.895423302 0.322417623 hsa-miR-340-star_st 2.98694447 0.554046449 3.285513465 0.458334824 hsa-miR-342-3p_st 11.3732498 1.157887161 10.39046304 1.180714755 hsa-miR-135b-star_st 8.205480844 0.391984069 9.048699314 0.80852354 hsa-miR-345_st 9.585480521 1.594889684 10.85019504 1.133284879 hsa-miR-1288_st 5.364443903 0.698325402 5.330922015 0.329331984 hsa-miR-135a_st 2.696558326 0.221709873 3.425990512 0.401453854 hsa-miR-34a-star_st 5.939815746 1.211467671 5.839418084 1.183024953 hsa-miR-34b_st 5.714549118 0.606605663 5.12154628 0.491265461 hsa-miR-4288_st 4.272715494 0.331460388 4.744027818 0.484048948 hsa-miR-222-star_st 7.010154205 0.423408346 6.06600137 1.065825549 hsa-miR-933_st 10.9807005 0.250931797 11.21594032 0.567461039 hsa-miR-361-3p_st 6.456586866 1.162052241 6.434510586 0.901194256 hsa-miR-224-star_st 5.662827689 0.382235707 5.715729444 0.614769307 hsa-miR-362-3p_st 5.078554082 0.884344704 4.777126243 0.59707651 hsa-miR-362-5p_st 6.883450714 0.610850787 6.775630923 0.773578669 hsa-miR-363_st 6.482254601 1.017180257 5.603879304 0.391840835 hsa-miR-363-star_st 10.08243004 0.498036011 9.574926234 0.502789225 hsa-miR-1979_st 14.64560218 0.536484465 15.49046718 0.418231714 hsa-miR-365-star_st 12.13543589 0.372526476 12.20874954 0.440561784 hsa-miR-548x_st 2.677428897 0.467398017 3.201151821 0.509250285 hsa-miR-367-star_st 3.166847803 0.47317429 3.14813309 0.452140821 hsa-miR-369-3p_st 2.986712428 0.496993332 3.166547872 0.494886052 hsa-miR-369-5p_st 3.867273705 0.336511795 3.884941004 0.37813369 hsa-miR-548l_st 5.464725767 0.585535491 5.372004472 0.371108133 hsa-miR-371-3p_st 4.274001054 0.542464216 3.92885324 0.369251829 hsa-miR-371-5p_st 12.8344501 0.662910031 12.95215371 0.372916854 hsa-miR-372_st 4.901782833 0.797445159 4.025947333 0.300770079 hsa-miR-373_st 5.517532556 0.387278109 5.290146355 0.623551837 hsa-miR-373-star_st 12.14504458 0.617728942 12.15353873 0.476208252 hsa-miR-374a_st 4.751465217 0.864374745 5.118922619 1.441028543 hsa-miR-374a-star_st 3.270840348 0.601541701 3.553759321 0.448996791 hsa-miR-500_st 6.175925689 0.319056244 6.557940805 0.816131249 hsa-miR-320c_st 10.38973963 0.407609195 10.67449306 0.388955681 hsa-miR-875-3p_st 4.636702262 0.435967865 4.828379715 0.31268407 hsa-miR-376a_st 4.933677887 0.669683185 4.294236037 0.610248294 hsa-miR-29b-1-star_st 6.808470164 0.317346313 6.096397657 0.920674858 hsa-miR-376b_st 3.53147834 0.349850591 3.483365476 0.467879354 hsa-miR-376c_st 5.2147317 1.628087929 4.425695976 0.551211008 hsa-miR-377_st 3.667466583 0.415227156 3.543131613 0.493522555 hsa-miR-377-star_st 5.07903151 0.735981217 4.987155571 0.76282856 hsa-miR-378_st 9.155255817 0.243916474 9.178607837 0.505865573 hsa-miR-378b_st 9.068725602 0.429584292 9.073970889 0.337357753 hsa-miR-378c_st 9.59748568 0.27894387 9.26254085 0.298557243 hsa-miR-378-star_st 5.35873851 0.602845881 5.265886412 0.449391717 hsa-miR-662_st 7.076468751 0.251589484 7.521307862 0.643808445 hsa-miR-379-star_st 3.439635437 0.515726961 3.605072764 0.46302619 hsa-miR-380_st 3.263296242 0.432914622 3.492819867 0.446812646 hsa-miR-380-star_st 4.082739738 0.425954689 3.581011012 0.332861275 hsa-miR-1274b_st 14.21859216 0.341467194 14.75215676 0.552398068 hsa-miR-382_st 6.844108166 0.488625795 6.70775011 0.673161113 hsa-miR-383_st 6.630387098 0.756701143 6.138350483 0.413981974 hsa-miR-384_st 2.62475599 0.594289301 2.97861799 0.581679666 hsa-miR-126-star_st 3.090618572 0.412755455 3.709486666 0.596771335 hsa-miR-409-5p_st 4.447520965 0.203889075 4.42663381 0.305651106 hsa-miR-410_st 4.445331541 0.201573144 4.354181733 0.269792822 hsa-miR-411_st 4.857105619 0.701521849 4.427464496 0.245855902 hsa-miR-411-star_st 4.816343005 0.481288843 4.497132142 0.512731249 hsa-miR-412_st 5.212752521 0.633443336 4.990380937 0.671858367 hsa-miR-3143_st 2.934661021 0.510147005 3.376775359 0.57561388 hsa-miR-422a_st 9.971119243 0.146842825 9.99541583 0.509299395 hsa-miR-628-5p_st 3.341885906 0.384759617 3.907357379 0.450726527 hsa-miR-423-5p_st 13.50054002 0.277482869 13.52187494 0.413675832 hsa-miR-27b-star_st 6.656510445 0.431747539 6.260466471 0.792349775 hsa-miR-499-5p_st 3.494440974 0.256101375 4.108858518 0.597579808 hsa-miR-425_st 8.149344131 1.320756171 8.379308962 0.938481978 hsa-miR-193b_st 8.060880165 0.705997143 8.05284561 1.052165679 hsa-miR-4252_st 5.623063449 0.498919065 5.487794629 0.478722537 hsa-miR-4253_st 12.29975327 0.372284206 12.35023599 0.390757523 hsa-miR-4254_st 5.836225877 0.530458734 5.53422782 0.584675308 hsa-miR-324-3p_st 7.930780917 0.340065786 8.603429333 0.628003845 hsa-miR-4329_st 5.008222334 0.367787358 5.316564196 0.419411743 hsa-miR-1251_st 4.485914886 0.415648951 4.809983142 0.542896674 hsa-miR-4258_st 6.333090277 0.816073816 6.053779074 0.884127425 hsa-miR-1274a_st 10.97591948 0.625871027 11.49387492 0.90734772 hsa-miR-425-star_st 8.476251492 0.477262594 8.146923251 0.447607298 hsa-miR-4260_st 11.29415184 0.652082284 11.32935691 0.450697853 hsa-miR-4261_st 9.459280319 0.32938108 9.347662405 0.436745988 hsa-miR-4262_st 3.466167525 0.606225256 3.503654702 0.520792155 hsa-miR-4263_st 3.799849718 0.19914035 3.556987922 0.498312439 hsa-miR-4264_st 3.237469816 0.425485262 3.300635174 0.470200734 hsa-miR-1280_st 14.21651563 0.690007938 15.20657291 0.45181172 hsa-miR-132-star_st 4.476731905 0.643431032 4.262178837 0.536337516 hsa-miR-4267_st 6.665799105 0.796017696 6.823276764 0.579931915 hsa-miR-4268_st 3.54207029 0.517899414 3.838903571 0.400783289 hsa-miR-133a_st 5.182983801 0.551544575 5.621377515 0.872669765 hsa-miR-888-star_st 3.612483776 0.850815377 3.719893202 0.299255072 hsa-miR-1260b_st 14.32586379 0.576309397 15.36453726 0.425912754 hsa-miR-4272_st 3.202665144 0.551825936 3.531059082 0.486605851 hsa-miR-4273_st 3.58266892 0.353144374 3.550680173 0.480943708 hsa-miR-4274_st 5.71460909 0.41323424 5.506414306 0.368001989 hsa-miR-4275_st 2.624976968 0.544435123 3.228973772 0.564291746 hsa-miR-4276_st 2.964511238 0.316609281 2.968249899 0.58351474 hsa-miR-4277_st 4.014194722 0.317811232 3.900972458 0.373218283 hsa-miR-4278_st 7.355075966 0.346658372 7.416346046 0.846871807 hsa-miR-4279_st 5.36463542 0.696142052 5.024418515 0.665814984 hsa-miR-4280_st 5.347313844 0.842412079 4.72171649 0.508782947 hsa-miR-4281_st 15.26645656 0.57839292 15.93454499 0.436729583 hsa-miR-4282_st 2.663950547 0.352345956 2.899083144 0.36583047 hsa-miR-4283_st 8.849144938 0.439411614 8.751144402 0.647567451 hsa-miR-4284_st 15.03758748 0.628266437 15.63455107 0.748864147 hsa-miR-23b-star_st 5.655365132 0.660897667 6.187247095 0.477791019 hsa-miR-574-3p_st 8.843824407 0.682077023 9.476594798 0.846282809 hsa-miR-4287_st 6.31590232 1.140026207 5.760932161 0.27283173 hsa-miR-320e_st 9.303242502 0.698514747 9.629066345 0.451491017 hsa-miR-339-5p_st 7.826006619 0.794859971 8.149693895 1.492391906 hsa-miR-505_st 5.613178946 0.858046346 6.152618643 0.741390891 hsa-miR-4290_st 6.531030796 0.626867363 5.932265364 0.650016998 hsa-miR-200b-star_st 6.509608956 0.633956213 6.869262003 0.42487672 hsa-miR-4292_st 8.636472189 0.469237906 8.391395154 0.535534681 hsa-miR-4293_st 5.650185679 0.620997527 5.229993773 0.486906139 hsa-miR-1246_st 12.63293369 0.75307796 13.44082138 0.384326801 hsa-miR-4295_st 3.715080304 0.525230144 3.665499751 0.428320447 hsa-miR-4296_st 7.544380309 0.522269686 7.1948071 0.654218085 hsa-miR-4297_st 6.162451907 1.295423249 5.762237388 0.784792458 hsa-miR-4298_st 13.0932607 0.350959943 13.25279635 0.29991741 hsa-miR-218_st 5.845160525 0.85479425 5.29779846 0.949266369 hsa-miR-4286_st 13.75185093 0.503259743 14.6658497 0.629276818 hsa-miR-4301_st 2.879288298 0.537823003 3.268037048 0.614296646 hsa-miR-4302_st 6.201551747 0.764939016 6.219510564 0.602679532 hsa-miR-365_st 4.105421402 0.450902318 5.028442045 1.063069828 hsa-miR-4304_st 7.263505113 0.791932081 6.698126224 0.673484963 hsa-miR-4305_st 3.821391963 0.290637775 3.979572912 0.769965645 hsa-miR-4306_st 9.680513718 0.297463542 9.416998374 0.537538758 hsa-miR-26a_st 14.06265926 0.643366569 14.51988806 0.645907622 hsa-miR-4308_st 3.399246698 0.419121852 3.533942319 0.569774082 hsa-miR-4309_st 4.284476362 0.16993954 4.373928527 0.358853407 hsa-miR-186_st 5.964983027 0.667842891 6.197142666 1.160061993 hsa-miR-4310_st 5.877304755 0.49986974 5.351169653 0.949576648 hsa-miR-4311_st 6.00514139 0.554220506 5.507993494 0.424596731 hsa-miR-4312_st 6.700974102 0.750195332 6.499226613 0.715576367 hsa-miR-4313_st 5.673163784 0.498057922 6.071167779 0.740165349 hsa-miR-4314_st 9.92478384 0.776279846 9.355904742 0.501936432 hsa-miR-4315_st 5.040244261 0.662159701 4.39870044 0.521955231 hsa-miR-149_st 6.25624792 0.788758754 6.594642354 0.674518316 hsa-miR-106b-star_st 7.091804467 0.703222616 7.23142957 0.518682637 hsa-miR-4318_st 5.164813579 0.431502162 4.91263378 0.231431961 hsa-miR-4319_st 5.240884066 0.474531261 4.851279225 0.976481454 hsa-miR-29b-2-star_st 7.198521986 0.498788185 7.432710584 0.498655518 hsa-miR-432_st 7.644471654 0.687486285 7.77954842 0.428486803 hsa-miR-4320_st 4.157803974 0.543855896 4.106276132 0.398947015 hsa-miR-522_st 3.752102979 0.369402226 4.152979731 0.429654915 hsa-miR-4322_st 13.18611103 0.416549346 13.29699992 0.417183912 hsa-miR-4323_st 5.546476182 0.613154407 4.929921719 0.449407249 hsa-miR-93-star_st 4.648957304 0.398472432 5.341887775 0.663163305 hsa-miR-4325_st 3.472812966 0.766111651 3.399023333 0.501138761 hsa-miR-4326_st 5.014180064 0.318783572 4.940786774 0.455168366 hsa-miR-874_st 13.10588124 0.455066955 13.29930115 0.440358508 hsa-miR-4328_st 3.446019697 0.553353619 3.282089766 0.502911911 hsa-let-7e-star_st 4.186213708 0.444279002 4.438840941 0.583980659 hsa-miR-720_st 15.16426802 0.588035966 15.92381617 0.488269767 hsa-miR-433_st 6.138137944 0.757675594 5.794120385 0.610340815 hsa-miR-4330_st 6.186930612 1.016268509 5.567521249 1.12727563 hsa-miR-448_st 3.63939461 1.007526253 4.052723609 0.422843127 hsa-miR-449a_st 4.057089965 0.373201367 3.807615469 0.451646959 hsa-miR-449b_st 5.593402581 0.571492419 5.24026024 0.633033943 hsa-miR-1975_st 15.17808808 0.544027633 15.91178915 0.500764593 hsa-miR-449c_st 7.356361981 0.810774526 7.251217892 0.973970395 hsa-miR-449c-star_st 4.818189122 0.514254502 4.631370238 0.391830188 hsa-miR-1_st 4.389598188 0.654375264 4.779897548 1.035204203 hsa-miR-450b-3p_st 2.69492697 0.419831728 3.024592864 0.712510111 hsa-miR-450b-5p_st 2.804658413 0.547349813 3.133244669 0.574826 hsa-miR-451_st 13.21390629 1.084231782 13.1075826 0.817803403 hsa-miR-452_st 7.377192127 0.625990407 6.838818678 0.440390878 hsa-miR-452-star_st 3.605993958 0.296250574 3.858275996 0.391258058 hsa-miR-548b-5p_st 4.351876204 0.244819683 4.352305991 0.305134798 hsa-miR-454-star_st 4.234173336 0.323346874 3.865179456 0.479665683 hsa-miR-455-3p_st 7.863868663 0.983258095 8.029366775 0.798250584 hsa-miR-455-5p_st 4.221440418 0.696422608 4.316368924 0.935095353 hsa-miR-466_st 5.76689287 0.167050777 5.622942711 1.064755284 hsa-miR-483-3p_st 6.320377239 0.637331415 6.460073402 0.730241126 hsa-miR-17_st 9.911407432 0.819706418 9.851855822 1.085095739 hsa-miR-320d_st 9.309138874 0.75865606 9.861194361 0.646697412 hsa-miR-485-3p_st 6.113855202 0.935453875 5.63373336 0.654373784 hsa-miR-485-5p_st 7.570602764 0.66882958 7.27549331 0.61145025 hsa-miR-486-3p_st 10.64593355 0.403981283 10.444397 0.696916964 hsa-miR-486-5p_st 7.958980322 0.994160211 8.197724973 0.68125073 hsa-miR-644_st 3.622779929 0.627546373 3.633581198 0.478493508 hsa-miR-3152_st 8.056812298 1.047881398 7.709297978 0.631389848 hsa-miR-488_st 3.781760961 0.385671248 3.69207105 0.482256574 hsa-miR-488-star_st 3.809190571 0.468919659 3.58041264 0.510211437 hsa-miR-450a_st 4.130970306 0.375060776 4.367793549 0.702786113 hsa-miR-20a_st 9.608873978 0.985258266 9.154240888 1.570959528 hsa-miR-484_st 7.397842875 0.867635174 8.167388556 0.811779194 hsa-miR-491-3p_st 4.855686496 0.242751543 4.84565073 0.414393313 hsa-miR-491-5p_st 9.424070653 0.422905689 9.282838637 0.541984612 hsa-miR-197_st 6.810682237 0.451539328 7.458081014 0.672627556 hsa-miR-493_st 5.809860932 0.652961754 5.721542924 0.501631458 hsa-miR-493-star_st 4.882266166 0.792426882 4.326393478 0.393539118 hsa-miR-494_st 15.19879237 0.537914517 15.71807116 0.302046259 hsa-miR-495_st 4.126178727 0.824723165 3.764773266 0.550530107 hsa-miR-496_st 3.013409544 0.537434768 3.24066256 0.340835478 hsa-miR-497_st 8.617519141 1.187029325 9.31253402 1.274820565 hsa-miR-497-star_st 3.617157328 0.411431969 3.541402348 0.288230566 hsa-miR-498_st 12.18788868 0.490031654 12.26996738 0.464060825 hsa-miR-499-3p_st 3.935294503 0.273929569 4.122394462 0.377211944 hsa-miR-24-1-star_st 3.99375153 0.649529313 4.371628213 1.095631286 hsa-miR-340_st 4.975184349 0.670618291 5.315422115 1.171203165 hsa-miR-500b_st 5.032541521 0.708096953 4.874411859 0.40238791 hsa-miR-500-star_st 9.469760732 0.243233572 9.55955348 0.377213895 hsa-miR-501-3p_st 9.481838831 0.440340115 9.546448548 0.454813052 hsa-miR-501-5p_st 6.318312489 0.092184448 6.420445453 0.618899598 hsa-miR-502-3p_st 9.21758196 0.185821322 9.335647904 0.323462784 hsa-miR-502-5p_st 5.671931897 0.529603559 5.403143638 0.5101396 hsa-miR-503_st 10.44903327 0.252694404 10.65776662 0.603084434 hsa-miR-192_st 7.289860068 0.925112021 7.360684321 1.337981563 hsa-let-7g_st 12.90594635 0.949684998 13.55886367 0.693278644 hsa-miR-505-star_st 7.694368548 0.362862247 7.629871326 0.595733983 hsa-miR-506_st 3.603103318 0.389611026 3.950790466 0.37721683 hsa-miR-507_st 3.400436032 0.345495971 3.384626045 0.54930887 hsa-miR-508-3p_st 3.175469508 0.373948827 3.412628275 0.613238957 hsa-miR-508-5p_st 9.332315514 0.481013307 9.176048356 0.479135237 hsa-miR-509-3-5p_st 7.741232586 0.835204717 6.965159833 1.084750535 hsa-miR-509-3p_st 6.163920072 0.678640656 6.203675997 0.598356854 hsa-miR-106a_st 9.68177744 0.931288539 9.644741005 1.143503481 hsa-miR-106b_st 8.745261083 0.744895877 9.031126071 1.148491266 hsa-miR-511_st 3.369775383 0.473241432 3.193442924 0.54137822 hsa-miR-512-3p_st 5.469054611 0.418419699 5.239480308 0.469294305 hsa-miR-512-5p_st 6.40508112 0.85242686 5.778311262 0.385036549 hsa-miR-513a-3p_st 2.938403512 0.707064858 3.108604996 0.324891244 hsa-miR-23a_st 13.40521412 0.83347076 13.99358348 0.686196145 hsa-miR-25_st 9.97963034 0.989496369 10.39025555 0.95623205 hsa-miR-598_st 5.757616441 0.675506113 6.053068424 1.053244455 hsa-miR-1260_st 10.6909495 0.949850747 11.79939741 0.512065319 hsa-miR-514b-3p_st 3.703986333 0.614638402 3.627111192 0.618112801 hsa-miR-514b-5p_st 11.29318544 0.384550635 11.31621348 0.457639244 hsa-miR-515-3p_st 4.421534265 0.559473177 4.47155921 0.45152108 hsa-miR-515-5p_st 3.421915412 0.46684992 3.637529256 0.417765063 hsa-miR-516a-3p_st 3.545396323 0.53388883 3.963442221 0.45977701 hsa-miR-27a_st 11.89840789 1.022894109 12.23697775 0.984413648 hsa-miR-100_st 11.53783501 0.875241413 12.32670387 0.953919607 hsa-miR-101_st 5.706489929 1.191460646 5.659717607 1.349211302 hsa-miR-517a_st 3.271203117 0.665778267 3.074939274 0.603651488 hsa-miR-517b_st 3.660535626 0.402079349 3.767684645 0.395297551 hsa-miR-517c_st 2.625496505 0.495948538 2.96173305 0.510418433 hsa-miR-517-star_st 5.616741984 0.383400145 5.356683141 0.438582595 hsa-miR-518a-3p_st 3.774515979 0.363039245 3.73146198 0.607125376 hsa-miR-518a-5p_st 7.546676851 0.895782651 7.51740602 0.772240288 hsa-miR-518b_st 3.957233855 0.431594022 4.028948225 0.69391213 hsa-miR-518c_st 2.820454585 0.516204781 3.252104081 0.538896342 hsa-miR-301a_st 4.001778778 0.790727646 4.377887613 0.789737028 hsa-miR-518d-3p_st 4.029427522 0.293696172 4.160632542 0.312335768 hsa-miR-518d-5p_st 6.959263894 0.529187537 6.837507757 0.444413667 hsa-miR-518e_st 2.942994704 0.702278282 3.099102503 0.301362312 hsa-let-7f_st 13.53844043 0.957531718 14.53149322 0.796521392 hsa-miR-518f_st 3.183794886 0.458314101 3.240782689 0.565568002 hsa-miR-1826_st 15.28967372 0.572637283 16.03679633 0.513337747 hsa-miR-519a_st 2.883068029 0.607674584 3.201570696 0.566257143 hsa-miR-519a-star_st 6.385948319 0.739472779 6.178999125 0.912215206 hsa-miR-519b-3p_st 2.966350161 0.530305981 3.394314329 0.603805215 hsa-miR-1283_st 3.818149664 0.362926775 4.008192314 0.396653707 hsa-miR-519c-3p_st 2.537597609 0.430574995 2.88125684 0.737785061 hsa-miR-519c-5p_st 6.773995045 0.419518244 6.311720462 0.639096658 hsa-miR-519d_st 3.719747083 0.486899762 3.729126735 0.282970933 hsa-miR-519e_st 3.666986117 0.537493088 4.05185554 0.380468692 hsa-miR-519e-star_st 7.852978474 0.806345684 7.463457108 0.47120124 hsa-miR-520a-3p_st 4.076495011 0.390757527 3.668711681 0.430966895 hsa-miR-1908_st 15.2900801 0.572704869 16.00657699 0.46917991 hsa-miR-520b_st 3.376673639 0.624027974 3.437756838 0.281553526 hsa-miR-520c-3p_st 4.124562316 0.670591664 4.20618397 0.519514433 hsa-miR-520c-5p_st 7.225873823 0.648600383 7.010128898 0.658126205 hsa-miR-181a-star_st 5.36162966 0.876368995 6.105419351 1.335539287 hsa-miR-21_st 12.27247487 0.867928278 11.72436469 1.579673894 hsa-miR-520e_st 3.34690233 0.461189419 3.332044154 0.580799756 hsa-miR-520f_st 3.569338857 0.494416808 3.675205079 0.569323742 hsa-miR-520g_st 3.715628237 0.263020239 3.790170258 0.426921536 hsa-miR-520h_st 3.581612961 0.629410226 3.615219658 0.301455663 hsa-miR-521_st 3.447586947 0.441975075 3.466793781 0.365156685 hsa-miR-302a-star_st 4.119283472 0.39086816 4.163693066 0.447726682 hsa-miR-886-3p_st 10.43594576 1.092375062 11.19634523 1.762310894 hsa-miR-523_st 3.250858763 0.678276609 3.526151865 0.428435737 hsa-miR-29a_st 12.88670674 0.881472224 13.3682967 0.902596082 hsa-miR-524-3p_st 4.280548548 0.231819334 4.288000107 0.36687549 hsa-miR-142-3p_st 3.39962904 1.044278077 3.278354139 0.381792283 hsa-miR-525-3p_st 3.284680499 0.529736098 3.556084102 0.473997043 hsa-miR-525-5p_st 6.339650463 0.388103515 6.633080915 0.666712414 hsa-miR-762_st 15.29003597 0.572739171 16.00868256 0.47157006 hsa-miR-423-3p_st 8.710366702 0.481880908 9.375177054 0.695775063 hsa-miR-449b-star_st 8.194175214 0.756235824 8.335174354 0.567521543 hsa-miR-527_st 7.767903981 0.551276159 7.80970047 0.744666167 hsa-miR-532-3p_st 7.354938434 0.920695458 8.044950525 0.85382626 hsa-miR-532-5p_st 7.887195197 0.778924247 8.068299035 0.976940353 hsa-miR-539_st 4.812742975 0.70860201 4.243994205 0.576836564 hsa-let-7a_st 13.49390454 0.924028709 14.52686123 0.602367564 hsa-miR-541-star_st 6.563153172 0.273867123 6.691637229 0.544815687 hsa-miR-542-3p_st 7.313408328 0.425071808 7.106489712 0.687807281 hsa-miR-542-5p_st 7.676313231 0.903749101 7.6481249 0.568575219 hsa-miR-543_st 4.628013935 0.368754234 5.007496684 0.468221753 hsa-miR-544_st 2.899953315 0.754057912 3.065592882 0.683140413 hsa-miR-544b_st 4.095844387 0.488886763 4.055365573 0.301503822 hsa-miR-545_st 2.963886737 0.517620244 3.251981938 0.520254616 hsa-miR-545-star_st 2.37005741 0.611119253 2.756596607 0.621606158 hsa-miR-548a-3p_st 2.610282927 0.82238186 3.042339563 0.605724721 hsa-miR-2861_st 15.28944857 0.572764211 16.02630754 0.496698468 hsa-miR-31_st 9.738405386 0.786490338 7.506889665 2.175620322 hsa-miR-367_st 3.04675118 0.510897062 3.453822947 0.635530205 hsa-miR-548c-3p_st 2.410143039 0.963087824 2.779940361 0.721422528 hsa-miR-548c-5p_st 5.275070459 1.546908633 4.8886108 0.751328454 hsa-miR-548d-3p_st 3.49829656 0.397604535 3.521580668 0.449347075 hsa-miR-548d-5p_st 4.42899606 0.912856187 4.487909444 0.671734608 hsa-miR-548e_st 3.029536788 0.694735974 3.139195386 0.645159795 hsa-miR-548f_st 2.890405204 0.630671192 3.402453836 0.56525575 hsa-miR-548g_st 2.555785224 0.914644246 3.09329926 0.540928993 hsa-miR-548h_st 3.715772486 0.398305069 3.607193114 0.376311953 hsa-miR-548i_st 4.445010549 0.460413642 4.414332592 0.563375846 hsa-miR-548j_st 4.816342289 0.480893369 4.398913565 0.358260768 hsa-miR-548k_st 3.553971503 0.199541141 3.697438969 0.427280207 hsa-miR-526b-star_st 3.174061704 0.691462473 3.510399179 0.623128916 hsa-miR-548m_st 3.913950845 0.502544334 3.922647559 0.49628704 hsa-miR-548n_st 3.35340513 0.621449025 3.36614022 0.455752058 hsa-miR-548o_st 2.729832663 0.534874975 3.01761268 0.609969399 hsa-miR-548p_st 3.005461492 0.435036534 3.112686142 0.470522725 hsa-miR-548q_st 9.784011814 0.652070751 9.777873729 0.686874287 hsa-miR-548s_st 3.267890179 0.311821367 3.429383231 0.376135277 hsa-miR-548t_st 4.254581329 0.552042309 4.100555118 0.361903307 hsa-miR-548u_st 2.735443914 0.709380949 2.973809617 0.496135649 hsa-miR-638_st 15.29028291 0.572807741 16.03093398 0.502496496 hsa-miR-548w_st 4.590615788 0.973916847 4.566189714 0.713827381 hsa-miR-3119_st 3.000516723 0.697574429 3.257485837 0.55539896 hsa-miR-549_st 4.060425511 0.522020166 3.983522539 0.447249415 hsa-miR-205_st 5.868416527 0.987107459 6.415302921 2.382372521 hsa-miR-550-star_st 5.120996416 0.244514565 4.806450169 0.523105909 hsa-miR-551a_st 4.84345183 0.563323547 4.718158107 0.292267281 hsa-miR-93_st 9.052819722 1.048751576 9.602934567 0.861987343 hsa-miR-551b-star_st 11.26848234 0.313339517 11.51505499 0.472085822 hsa-let-7d-star_st 7.193338978 0.271677733 8.029863583 0.576215859 hsa-miR-553_st 3.316698717 0.503749243 3.47194354 0.470110839 hsa-miR-554_st 4.232798834 0.61087144 4.169610062 0.414779198 hsa-miR-555_st 3.931142226 0.335045289 4.215636391 0.515013168 hsa-miR-556-3p_st 3.366659802 0.553422029 3.704729374 0.651918059 hsa-miR-556-5p_st 2.62303551 0.706559957 3.313155654 0.438176022 hsa-miR-557_st 12.2567656 0.429379501 12.16115603 0.474097753 hsa-miR-558_st 3.184928756 0.846770143 3.452420312 0.472527971 hsa-miR-559_st 3.262389309 0.644459838 3.480608437 0.50623961 hsa-miR-561_st 3.058835091 0.603788142 3.365824062 0.528766736 hsa-miR-562_st 2.974325726 0.559682007 3.535781894 0.525761053 hsa-miR-563_st 4.124724553 0.293130513 4.059812431 0.589158686 hsa-miR-361-5p_st 10.28905064 0.705634134 10.8588484 0.685039395 hsa-miR-566_st 6.679007388 0.358665264 6.57084305 0.762437039 hsa-miR-567_st 4.161498595 0.357710399 4.179227014 0.468556718 hsa-miR-568_st 2.784968005 0.545654278 3.263821719 0.369748616 hsa-miR-29c_st 10.98554772 0.838199398 11.70967646 0.908751687 hsa-miR-570_st 3.374409593 0.689094926 3.483412582 0.390703995 hsa-miR-571_st 4.101191188 0.398495693 4.417011732 0.487564824 hsa-miR-572_st 14.39070447 0.519961869 14.51032918 0.499463303 hsa-miR-573_st 3.33537827 0.473493568 3.580436095 0.475203324 hsa-miR-132_st 6.409005228 0.806207614 6.482435009 0.847705632 hsa-miR-574-5p_st 8.108251814 0.19086485 8.011848197 0.492410397 hsa-let-7d_st 13.00989227 0.969917961 4.05239565 0.684022426 hsa-miR-576-3p_st 4.658689063 0.441771213 4.619422191 0.38411683 hsa-miR-576-5p_st 4.335024532 0.596901908 4.022535217 0.519644766 hsa-miR-577_st 3.319513114 0.616278548 3.42955308 0.4765682 hsa-miR-578_st 4.32295386 0.450696413 4.463240952 0.520416353 hsa-miR-579_st 3.282298524 0.3249947 3.642694969 0.327077149 hsa-miR-580_st 2.980375615 0.655879331 3.40622339 0.525531015 hsa-miR-191_st 11.53521188 1.016026799 12.21787403 0.831991222 hsa-miR-582-3p_st 4.03649104 0.586109493 4.190053542 0.633941549 hsa-miR-582-5p_st 4.294780284 1.216725462 3.612554114 0.669510381 hsa-miR-1915_st 15.28992116 0.572684222 16.03640504 0.512507373 hsa-let-7c_st 12.92940572 0.905539378 13.92261478 0.669396526 hsa-miR-585_st 3.891254254 0.499421956 3.734859803 0.494313938 hsa-miR-586_st 3.137645614 0.502218636 3.323442187 0.58307489 hsa-miR-324-5p_st 7.901753598 0.535488121 8.422669425 1.238809139 hsa-miR-588_st 5.50223679 0.449128666 5.19651698 0.521013227 hsa-miR-589_st 5.100173667 0.568284802 4.783919018 0.608355677 hsa-miR-589-star_st 5.144599194 0.44850186 5.218465403 0.510398323 hsa-miR-188-5p_st 8.458269738 0.628579965 8.982324701 0.405872937 hsa-miR-103_st 11.57943947 1.03845505 12.35592736 0.859634731 hsa-miR-591_st 4.276292827 0.69395926 4.136078358 0.481789689 hsa-miR-592_st 3.277573248 0.387020942 3.279188464 0.37909087 hsa-miR-593_st 6.21139341 0.596413941 6.33737736 0.733721387 hsa-miR-23b_st 13.23856481 0.848654137 14.07858579 0.66207202 hsa-miR-595_st 7.257458881 0.514116023 7.292184768 0.414813816 hsa-miR-99a_st 11.3875049 1.007363751 12.3463053 0.847981797 hsa-miR-15b_st 9.442335529 0.87290396 10.0199783 0.84067346 hsa-miR-135b_st 3.22945361 0.798396855 4.304817665 1.218005328 hsa-miR-599_st 2.76524505 0.572996946 3.245363125 0.545230737 hsa-miR-600_st 6.423478596 0.694574436 7.278047979 0.984262659 hsa-miR-107_st 11.41799085 1.035072958 12.31077559 0.791342542 hsa-miR-602_st 13.97699159 0.378094594 14.08554857 0.485198154 hsa-miR-603_st 2.727733058 0.627721695 3.142942335 0.390579257 hsa-miR-3065-5p_st 3.808900144 0.442606824 4.418614984 0.809191034 hsa-miR-605_st 6.249296511 1.054617464 5.683706597 0.786049366 hsa-miR-24_st 12.25538638 0.953017587 12.80686121 0.782954798 hsa-miR-607_st 3.255728844 0.58959146 3.500577783 0.428756962 hsa-miR-608_st 9.590752811 0.590820876 9.53961264 0.58609811 hsa-miR-609_st 3.996156246 0.652157964 3.597583444 0.530770225 hsa-miR-3196_st 15.29002273 0.57271799 16.03737462 0.513859846 hsa-miR-26b_st 11.45504823 0.943624605 12.16655225 1.203426527 hsa-miR-28-5p_st 8.391016946 1.046500749 9.30035099 0.740055614 hsa-miR-613_st 4.648040923 0.614347931 4.172820101 0.560761512 hsa-miR-338-3p_st 3.798822829 0.590491859 4.38968126 0.949680643 hsa-miR-615-3p_st 7.737253651 0.72675537 7.469800936 0.654218859 hsa-miR-454_st 5.197679188 0.858166962 5.712982854 1.42285409 hsa-miR-616_st 8.072487885 0.683217845 7.689660531 0.469271941 hsa-miR-151-5p_st 10.80629037 1.103200741 11.64328037 0.729890198 hsa-miR-617_st 7.551803162 1.170711196 7.332988086 0.940263891 hsa-miR-128_st 7.202727337 1.15596349 7.869565664 0.931548446 hsa-miR-619_st 4.728674725 0.323584208 4.662569665 0.316095423 hsa-miR-620_st 3.802758564 0.358673474 3.963262056 0.668118775 hsa-miR-621_st 3.74897129 0.561999668 3.955204814 0.470633985 hsa-let-7b_st 11.82806599 0.842525676 12.82209662 0.677290735 hsa-miR-623_st 9.885798422 0.578155336 10.00710148 0.32620826 hsa-miR-624_st 3.969520828 0.422886781 4.261004215 0.314980347 hsa-miR-624-star_st 3.99343912 0.476864051 4.379409284 0.422719322 hsa-miR-183_st 5.058453265 0.971905538 6.982039097 1.259277558 hsa-miR-30b_st 11.59116391 1.198122831 12.69215784 0.779902862 hsa-miR-626_st 3.472680424 0.308422515 3.594160316 0.35465532 hsa-miR-627_st 3.129072514 0.539810849 3.576409299 0.385146715 hsa-miR-628-3p_st 11.47691285 0.579422553 11.45508435 0.615383402 hsa-miR-31-star_st 5.239646036 1.296229106 3.911476855 1.459314421 hsa-miR-218-1-star_st 4.062996958 0.285920264 3.98423594 0.630313349 hsa-miR-629-star_st 5.871066716 0.60748575 5.527233816 0.794129897 hsa-miR-630_st 8.938538143 0.977584959 8.806119351 0.595064206 hsa-miR-631_st 7.583534799 0.816214035 7.667707635 0.564391862 hsa-miR-632_st 4.916232896 0.800829888 4.822393076 0.606808758 hsa-miR-633_st 3.138674965 0.385893297 3.460051755 0.433740557 hsa-miR-634_st 6.258339453 0.620137849 6.240889141 1.272817359 hsa-miR-635_st 5.659248769 0.562681519 5.336673748 0.464412411 hsa-miR-203_st 6.423540288 1.084374656 7.439440382 2.171340814 hsa-miR-331-3p_st 8.472148194 1.187506452 10.23847105 0.646203126 hsa-miR-125b_st 13.09949383 0.702109457 14.20146519 0.464250863 hsa-let-7i_st 12.38948499 1.068896617 13.38923547 0.90753087 hsa-miR-640_st 6.219733565 0.794497856 5.873776145 0.601973187 hsa-miR-641_st 5.081677999 0.562050584 4.687074703 0.521783455 hsa-miR-642_st 4.223877565 0.272662971 4.160296476 0.366923815 hsa-miR-29b_st 11.01764744 0.888887242 11.7114879 1.190344904 hsa-miR-122_st 4.895684511 0.615743826 4.985849804 0.588096431 hsa-miR-645_st 4.965567166 0.681846899 4.379976944 0.425810106 hsa-miR-646_st 3.983426491 0.385495041 3.865908609 0.462377226 hsa-miR-647_st 5.055109578 0.279663437 5.076084146 0.579340545 hsa-miR-648_st 8.923372156 0.539030404 8.902512523 0.382869928 hsa-miR-649_st 4.624207587 0.685058185 4.075665045 0.456131096 hsa-miR-182_st 7.769010972 1.561712896 9.605644942 1.274144167 hsa-miR-651_st 3.482006648 0.157469598 3.406635002 0.439939363 hsa-miR-652_st 7.369480423 0.632957095 7.746298654 0.569445151 hsa-miR-653_st 3.076122594 0.514068141 3.31670527 0.59769199 hsa-miR-654-3p_st 4.614610453 0.720513685 4.355051691 0.504758262 hsa-miR-374b_st 6.394959207 1.182598946 7.183771368 1.711235299 hsa-miR-130a_st 10.08020103 0.766377135 10.35948611 0.984003351 hsa-miR-656_st 3.59368367 0.472311599 3.947381839 0.590640879 hsa-miR-657_st 4.78824282 0.50310201 4.180997774 0.448545847 hsa-miR-658_st 11.96276372 0.309542793 11.9505532 0.56871267 hsa-miR-99b_st 10.02021362 0.862994708 11.04204106 0.68261512 hsa-miR-660_st 7.246923416 1.367556434 7.487634613 1.430580082 hsa-miR-661_st 7.533247906 0.825409084 7.506004453 0.560404748 hsa-miR-30e-star_st 8.42191393 1.335578255 9.774091051 1.018720998 hsa-miR-663_st 15.28550632 0.571581079 15.80827195 0.407674765 hsa-miR-663b_st 10.65684266 0.592315565 10.46373313 0.5485667 hsa-miR-664_st 7.01565408 1.289861677 7.844233025 1.041008225 hsa-miR-664-star_st 10.0060307 1.053638776 10.59163044 0.377126646 hsa-miR-30d_st 11.25273078 1.214156415 12.48864482 0.640175272 hsa-miR-668_st 8.777045639 0.884135631 8.349651293 0.553983542 hsa-miR-670_st 5.747310405 0.87405109 5.440136642 0.492183582 hsa-miR-671-3p_st 7.584270412 0.260656901 7.080120327 0.695437942 hsa-miR-671-5p_st 12.35270782 0.454811243 12.42958886 0.478610556 hsa-miR-30a-star_st 8.899101909 1.483153656 9.976705262 1.063451556 hsa-miR-675-star_st 4.958203797 0.233639639 4.91946789 0.606874936 hsa-miR-148b_st 7.599713165 1.477317145 9.397418032 0.881095209 hsa-miR-708_st 7.193578542 0.633795806 7.917505926 1.763072643 hsa-miR-708-star_st 4.297842687 0.589554105 4.496346151 0.639644594 hsa-miR-221-star_st 6.853765937 0.886890319 6.279868601 1.986845527 hsa-let-7e_st 11.21243375 1.184807777 12.54330551 0.747295788 hsa-miR-7-1-star_st 6.095382778 0.838985946 5.766972965 1.186764016 hsa-miR-27b_st 11.22252658 1.330058545 12.22584587 1.067712522 hsa-miR-34a_st 8.563929477 1.30131094 9.368804664 1.531181708 hsa-miR-744_st 14.47352761 0.342781621 14.55719276 0.521324827 hsa-miR-744-star_st 5.129903524 0.401186334 5.18542505 0.736418494 hsa-miR-92b_st 7.757655051 0.621429065 8.64744807 0.847459277 hsa-miR-759_st 3.342634429 0.474872115 3.245981812 0.450738006 hsa-miR-760_st 10.31269004 0.338453418 10.33090223 0.410477449 hsa-miR-92a_st 9.860196166 0.874640451 0.66034641 0.60031385 hsa-miR-335_st 7.44065986 1.237982497 8.849757809 1.529777317 hsa-miR-96_st 4.916560095 1.726381766 6.782817325 1.392668119 hsa-miR-95_st 6.419503319 1.160882877 8.038699553 1.453109928 hsa-miR-766_st 8.121625224 1.169206144 7.444029713 0.490436233 hsa-miR-767-3p_st 4.399336486 0.451181211 4.356266772 0.58142475 hsa-miR-767-5p_st 4.281355069 0.569537805 4.293036544 0.383117083 hsa-miR-98_st 8.291406338 1.336101601 9.857443481 1.140926706 hsa-miR-769-5p_st 7.177465602 0.466270242 6.990061913 0.784687248 hsa-miR-770-5p_st 7.848862898 0.7354968 7.547105066 0.572219956 hsa-miR-802_st 2.820589581 0.503225295 3.168207515 0.596932763 hsa-miR-34b-star_st 4.884535734 1.330390012 5.785437325 1.094083237 hsa-miR-581_st 3.153942853 0.882257369 3.282757323 0.579800174 hsa-miR-181d_st 7.775845323 0.583324649 8.771388849 0.75547687 hsa-miR-875-5p_st 2.780704052 0.605992878 2.954163167 0.673656846 hsa-miR-876-3p_st 3.476204212 0.513375572 3.244079558 0.511027703 hsa-miR-876-5p_st 2.515085897 0.499140897 2.991209608 0.517939126 hsa-miR-151-3p_st 7.815485225 1.232437266 8.961126175 0.788320496 hsa-miR-877-star_st 6.836231238 0.750969254 6.233888885 0.649756636 hsa-miR-885-3p_st 13.17428473 0.372180383 13.35023301 0.523191421 hsa-miR-200c_st 11.72731562 1.146003666 13.54032501 0.628311183 hsa-miR-429_st 5.098363608 0.933323131 5.221627301 1.532553961 hsa-miR-886-5p_st 12.34586273 0.27548468 12.55590537 0.704659672 hsa-miR-224_st 5.699424326 0.463733371 6.820475407 1.296131582 hsa-miR-888_st 3.842608416 0.483434965 3.490770866 0.30311243 hsa-miR-4321_st 10.22451298 0.650138855 10.21041952 0.685719231 hsa-miR-889_st 3.607345442 0.389911157 3.648761784 0.419176963 hsa-miR-181b_st 8.89460766 0.440451072 9.950002863 0.865528583 hsa-miR-891a_st 6.877292691 0.505592784 6.907550631 0.792713463 hsa-miR-891b_st 3.438624537 0.53362213 4.002907223 0.360911427 hsa-miR-892a_st 4.704843624 0.944356777 4.65874597 0.61843953 hsa-miR-892b_st 5.006578747 0.597825949 4.727139299 0.596919606 hsa-miR-9_st 2.982215752 0.824162199 3.082438366 0.422994955 hsa-miR-222_st 11.62178498 0.926089153 11.48568956 2.126605516 hsa-miR-141_st 7.986905514 1.050589987 9.444311432 1.261764382 hsa-miR-221_st 11.60624812 0.988222465 11.81048476 2.19478178 hsa-miR-924_st 4.181057075 0.286787968 3.951915242 0.361943585 hsa-miR-181a_st 10.43765387 0.698446862 11.80267122 1.106291877 hsa-miR-181c_st 7.148352425 0.938790181 8.61671884 1.3557679 hsa-miR-4324_st 8.603306258 0.877013854 9.959830037 0.788616582 hsa-miR-125a-5p_st 11.75031192 0.767109329 13.35353695 0.62986375 hsa-miR-92b-star_st 14.57472977 0.39560879 14.83763365 0.444937351 hsa-miR-3195_st 13.30765887 0.582622655 13.32069034 0.718420244 hsa-miR-3137_st 11.58702289 0.836696507 11.62210382 0.443187468 hsa-miR-934_st 5.310817656 0.640263781 5.439073765 0.386455103 hsa-miR-935_st 4.623022642 0.886389105 4.704866773 0.37050234 hsa-miR-551b_st 3.766884015 0.279425944 4.130794671 1.129943036 hsa-miR-937_st 5.847801764 0.56164225 5.684689342 0.591690475 hsa-miR-938_st 4.932998476 0.731224911 4.946088502 0.515203533 hsa-miR-939_st 13.30913259 0.486002491 13.39199249 0.388159133 hsa-miR-7-2-star_st 5.128238135 0.876272281 7.414220509 1.685048772 hsa-miR-146b-5p_st 10.89707591 1.136970312 8.554021569 1.874250075 hsa-miR-941_st 5.920500651 0.548773823 5.822420998 0.35837617 hsa-miR-942_st 3.234496233 0.552133472 3.333967456 0.460742946 hsa-miR-200a_st 7.961812576 1.302057287 8.66965769 1.798567474 hsa-miR-944_st 3.377714124 0.567991126 3.599649798 0.526598467 hsa-miR-7_st 5.891833519 1.306520378 9.28147776 2.855280788 hsa-miR-375_st 5.491371894 0.284535933 5.116386036 0.888493672 hsa-miR-96-star_st 4.320346138 0.178619073 4.463952783 0.451769451 hsa-miR-424_st 6.750810254 1.251319367 8.245023788 1.319910967 hsa-miR-181a-2-star_st 6.495686121 1.145057647 6.932623147 1.227627845 hsa-miR-200b_st 8.841953131 1.654855811 10.16671313 1.530518629 hsa-miR-146b-3p_st 4.625036094 0.588004522 4.434495292 0.48125597 hsa-miR-99b-star_st 7.772704802 0.29446734 7.767958559 0.488768244 hsa-miR-9-star_st 4.860168706 0.643219089 4.051633994 0.728291835 Mean STDEV Sample Name FTC FTC hsa-miR-150_st 9.684397839 2.030200595 hsa-let-7a-2-star_st 4.801992143 0.40031824 hsa-let-7a-star_st 3.372863948 0.306870458 hsa-miR-513b_st 10.07239541 2.125055801 hsa-let-7b-star_st 7.521110163 1.210668934 hsa-miR-593-star_st 9.057241317 1.600550953 hsa-let-7c-star_st 5.197424112 0.716116771 hsa-miR-516a-5p_st 6.658268436 0.812874467 hsa-miR-142-5p_st 5.708297995 1.71919978 hsa-miR-650_st 11.08938602 0.39959731 hsa-miR-513c_st 7.291099373 1.373270189 hsa-miR-761_st 8.468850929 0.776150804 hsa-let-7f-1-star_st 5.22210362 0.445825202 hsa-miR-513a-5p_st 12.06848022 1.449363159 hsa-miR-654-5p_st 10.86471312 0.810883571 hsa-let-7g-star_st 4.851538847 0.382169199 hsa-miR-3163_st 8.450927076 0.793994625 hsa-let-7i-star_st 6.467173826 1.038849141 hsa-miR-3165_st 7.118819069 1.461449021 hsa-miR-3194_st 11.03308357 0.823888489 hsa-miR-100-star_st 3.11199991 0.622316476 hsa-miR-4251_st 6.441924053 0.885883403 hsa-miR-101-star_st 4.155607649 0.372058207 hsa-miR-922_st 6.063270798 0.86276452 hsa-miR-103-2-star_st 5.863656252 0.544295147 hsa-miR-155_st 9.543627212 1.471316722 hsa-miR-105_st 3.561756364 0.349405295 hsa-miR-127-5p_st 7.39917444 1.106211408 hsa-miR-1286_st 9.30499447 0.926152319 hsa-miR-106a-star_st 3.47848361 0.463543538 hsa-miR-890_st 6.84526332 1.196583479 hsa-miR-3126-5p_st 12.11210691 1.209546766 hsa-miR-489_st 9.726249388 1.316939018 hsa-miR-10a_st 8.559776736 1.511251806 hsa-miR-10a-star_st 4.667641659 0.258326618 hsa-miR-10b_st 9.952445986 1.3589001 hsa-miR-10b-star_st 5.059550184 0.693997383 hsa-miR-1178_st 4.496572393 0.480703396 hsa-miR-1179_st 3.486327382 0.457479467 hsa-miR-1180_st 9.227827435 0.337139575 hsa-miR-1181_st 9.369702547 0.658781274 hsa-miR-3138_st 10.78042744 1.23650974 hsa-miR-220c_st 6.492846656 0.731310485 hsa-miR-510_st 8.790855126 1.168963799 hsa-miR-1185_st 2.89975365 0.357709501 hsa-miR-1193_st 10.34571118 0.281969656 hsa-miR-1197_st 3.690595104 0.142039776 hsa-miR-1200_st 4.308937174 0.350211284 hsa-miR-1201_st 9.679543348 0.724633127 hsa-miR-1202_st 13.44070266 0.536454895 hsa-miR-30c-1-star_st 10.25428921 1.076886846 hsa-miR-1204_st 4.919279224 0.60261043 hsa-miR-1205_st 4.305331921 0.393146727 hsa-miR-1206_st 3.14827082 0.2500933 hsa-miR-1207-3p_st 4.176996676 0.520126092 hsa-miR-1207-5p_st 14.63438172 0.186223239 hsa-miR-1208_st 10.64451191 0.443782496 hsa-miR-622_st 9.076980683 0.757941588 hsa-miR-1224-3p_st 5.920681533 0.413151009 hsa-miR-2116_st 5.930670742 0.684583768 hsa-miR-1225-3p_st 6.297214822 0.319139341 hsa-miR-1225-5p_st 14.33743774 0.240262364 hsa-miR-1226_st 5.748037513 0.729821207 hsa-miR-30b-star_st 8.82906613 0.856938386 hsa-miR-1227_st 4.347000634 0.45037551 hsa-miR-1295_st 6.442125044 0.797678092 hsa-miR-1228-star_st 15.44532655 0.287252796 hsa-miR-20b_st 9.567595294 0.788174842 hsa-miR-122-star_st 3.275916843 0.390681148 hsa-miR-1231_st 14.30384357 0.322854194 hsa-miR-1233_st 6.146864348 0.527439621 hsa-miR-524-5p_st 5.617376015 0.437605645 hsa-miR-1236_st 6.156793888 0.318972586 hsa-miR-873_st 5.176832238 0.944395 hsa-miR-1238_st 7.318574027 0.283427483 hsa-miR-124_st 8.932397447 0.783450461 hsa-miR-1243_st 4.276596714 0.371460914 hsa-miR-1244_st 8.733595356 1.083387346 hsa-miR-1245_st 4.001232657 0.33931703 hsa-miR-3122_st 11.63630869 0.328402849 hsa-miR-134_st 9.883706365 0.610515281 hsa-miR-1248_st 10.69204902 1.568204691 hsa-miR-146a_st 8.888497102 1.487954143 hsa-miR-124-star_st 5.341966048 0.331174717 hsa-miR-1250_st 8.004089295 0.471851264 hsa-miR-764_st 5.457037176 0.811159414 hsa-miR-1252_st 3.21393874 0.37811015 hsa-miR-223_st 9.529322428 1.891176982 hsa-miR-34c-3p_st 8.229898667 0.847346814 hsa-miR-1255a_st 5.593509045 0.818559082 hsa-miR-1255b_st 8.167177678 1.29757817 hsa-miR-1256_st 3.872217782 0.428124334 hsa-miR-1257_st 5.236460925 0.506142245 hsa-miR-199b-5p_st 6.266646668 2.494363747 hsa-miR-1259_st 3.21314522 0.448890093 hsa-miR-492_st 8.999530322 0.441067934 hsa-miR-3132_st 9.678800325 0.650675187 hsa-miR-516b_st 6.973819553 1.06256649 hsa-miR-4294_st 8.691559725 1.067271513 hsa-miR-125b-2-star_st 10.37956176 1.054426987 hsa-miR-126_st 14.08130644 0.430060292 hsa-miR-198_st 12.33326178 0.828347642 hsa-miR-3191_st 11.85803443 0.920300444 hsa-miR-1261_st 7.535298754 1.088249212 hsa-miR-1262_st 4.302906304 0.516453445 hsa-miR-1263_st 4.468539056 0.528640803 hsa-miR-1264_st 3.461767589 0.490326851 hsa-miR-1265_st 5.503663375 0.500094805 hsa-miR-2114-star_st 7.16983379 1.192321836 hsa-miR-1267_st 4.150503304 0.267068704 hsa-miR-1268_st 14.25949219 0.191856461 hsa-miR-1269_st 5.938102341 0.526470159 hsa-miR-509-5p_st 6.081842306 0.792727654 hsa-miR-1270_st 6.494065335 0.632697671 hsa-miR-1271_st 8.045762953 0.631924217 hsa-miR-4303_st 6.840657169 0.793532317 hsa-miR-1273_st 10.01663585 0.864017561 hsa-miR-583_st 7.727106137 0.721974354 hsa-miR-1273d_st 10.75240388 0.507761118 hsa-miR-127-3p_st 6.448008252 1.803960093 hsa-miR-522-star_st 6.352051657 0.367469875 hsa-miR-214-star_st 5.39072323 1.448818619 hsa-miR-184_st 8.340582696 0.880349373 hsa-miR-614_st 6.30527271 1.061593282 hsa-miR-526b_st 5.962668217 0.426201988 hsa-miR-1277_st 3.297477828 0.256361604 hsa-miR-1278_st 4.05045819 0.422846181 hsa-miR-1279_st 3.365732577 0.417759882 hsa-miR-409-3p_st 6.441772661 1.162198954 hsa-miR-199a-5p_st 9.543793019 1.961495064 hsa-miR-1281_st 9.738350928 0.476501133 hsa-miR-1282_st 4.029630098 0.783351704 hsa-miR-33b-star_st 7.296620081 0.391831638 hsa-miR-1284_st 5.232096661 0.568826119 hsa-miR-1253_st 4.935285921 0.469735636 hsa-miR-584_st 7.627957116 0.701474559 hsa-miR-1287_st 6.444806627 0.420992295 hsa-miR-15a_st 11.20760903 0.607754854 hsa-miR-1289_st 4.709557118 0.717017416 hsa-miR-1290_st 10.8100822 0.839820881 hsa-miR-2117_st 3.882431528 0.457372323 hsa-miR-1292_st 12.57355094 0.37919776 hsa-miR-1293_st 7.427683447 0.295893299 hsa-miR-129-3p_st 3.842349929 0.518420222 hsa-miR-520d-5p_st 7.32057227 0.437487875 hsa-miR-526a_st 7.124328592 0.467985129 hsa-miR-129-5p_st 11.7877797 0.3716748 hsa-miR-1254_st 11.73016451 0.756583376 hsa-miR-1297_st 3.006529906 0.409742957 hsa-miR-1298_st 4.867614588 0.59670062 hsa-miR-1299_st 5.532663926 1.322641098 hsa-miR-129-star_st 4.319834478 0.533748872 hsa-miR-1301_st 8.642167863 0.177194896 hsa-miR-19b_st 10.64366877 0.495558783 hsa-miR-1303_st 10.70658683 0.426205016 hsa-miR-1304_st 7.670429896 0.921835503 hsa-miR-1305_st 4.076897822 0.417444591 hsa-miR-550_st 12.10356348 0.639005483 hsa-miR-1307_st 13.80208558 0.338179238 hsa-miR-1308_st 15.16215606 0.646017669 hsa-miR-4291_st 7.800841809 0.563278306 hsa-miR-130a-star_st 4.021740095 0.420688406 hsa-miR-130b_st 8.39229655 0.870958584 hsa-miR-130b-star_st 5.038512793 0.666110913 hsa-miR-921_st 11.65503813 0.877904978 hsa-miR-520a-5p_st 4.885617889 0.479530704 hsa-miR-711_st 12.14191487 0.510821702 hsa-miR-1323_st 8.517354804 0.45686443 hsa-miR-1324_st 3.351568117 0.562460357 hsa-miR-490-3p_st 6.123846509 0.41546502 hsa-miR-718_st 8.645398149 0.458718515 hsa-miR-133b_st 5.610531106 2.724024548 hsa-miR-431-star_st 6.553444872 0.300824565 hsa-miR-552_st 5.683650375 0.774719019 hsa-miR-28-3p_st 8.007495893 1.201147279 hsa-miR-4265_st 8.08795367 0.41000352 hsa-miR-643_st 3.976928251 0.558305835 hsa-miR-136_st 2.969563212 0.23345605 hsa-miR-136-star_st 3.128279102 0.36709184 hsa-miR-137_st 3.378087112 0.296252689 hsa-miR-138_st 9.992441972 1.61833596 hsa-miR-138-1-star_st 8.356146038 1.011487779 hsa-miR-138-2-star_st 5.448002704 0.426649171 hsa-miR-139-3p_st 8.17866992 0.522321927 hsa-miR-139-5p_st 7.71786577 1.490029753 hsa-miR-140-3p_st 10.94742817 0.797696947 hsa-miR-140-5p_st 6.540010051 0.999270696 hsa-miR-381_st 6.641994895 0.620288607 hsa-miR-141-star_st 3.799427769 0.408140134 hsa-miR-17-star_st 6.874398034 0.665879157 hsa-miR-4300_st 8.207999171 0.407383826 hsa-miR-143_st 12.3724 0.912433112 hsa-miR-143-star_st 6.748965421 1.106862092 hsa-miR-144_st 3.380806472 0.44073448 hsa-miR-3198_st 9.922115931 0.559358676 hsa-miR-145_st 12.96810302 1.224620382 hsa-miR-145-star_st 6.018243807 1.321094299 hsa-miR-1468_st 5.951634337 0.403696958 hsa-miR-1469_st 15.76481188 0.384176259 hsa-miR-1973_st 14.50158725 1.124348058 hsa-miR-3154_st 11.52524842 0.447345791 hsa-miR-148a-star_st 5.653785589 1.010896254 hsa-miR-92a-1-star_st 8.067286858 0.264280878 hsa-miR-147_st 4.025157603 0.518176196 hsa-miR-194-star_st 8.884856939 0.58032204 hsa-miR-1471_st 10.51673808 0.754633045 hsa-miR-147b_st 4.521029922 0.28223738 hsa-miR-148a_st 11.90540704 1.476361126 hsa-miR-4299_st 13.27685499 1.559239506 hsa-miR-135a-star_st 12.8429315 0.582365542 hsa-miR-612_st 11.82296472 0.536530807 hsa-miR-1321_st 7.644516768 0.492661734 hsa-miR-149-star_st 15.6720287 0.259673068 hsa-miR-604_st 8.975960499 1.169815451 hsa-miR-150-star_st 14.18390995 0.301402314 hsa-miR-125b-1-star_st 11.66287727 0.636846132 hsa-miR-1183_st 10.18594529 0.65309625 hsa-miR-152_st 10.94107803 0.766307302 hsa-miR-153_st 3.483394959 0.583311448 hsa-miR-1537_st 3.429463182 0.32274722 hsa-miR-1538_st 7.672519742 0.568179915 hsa-miR-1539_st 5.831050586 0.290805108 hsa-miR-154_st 4.453397304 1.051347967 hsa-miR-154-star_st 4.531144987 0.488827929 hsa-miR-432-star_st 4.861411452 0.651883684 hsa-miR-155-star_st 3.654999072 0.488749231 hsa-miR-298_st 10.8586502 0.603875865 hsa-miR-15a-star_st 4.690518246 0.591470645 hsa-miR-2110_st 10.9707848 0.766624212 hsa-miR-15b-star_st 3.706761596 0.291785894 hsa-miR-1266_st 9.510446132 0.512890477 hsa-miR-16-1-star_st 4.547784458 0.271903713 hsa-miR-16-2-star_st 4.675998573 0.832093841 hsa-miR-490-5p_st 7.554610413 0.62657975 hsa-miR-19a_st 6.530567548 0.912312856 hsa-miR-3192_st 9.047569026 0.510968073 hsa-miR-3155_st 7.720338464 0.563721376 hsa-miR-187-star_st 10.9811868 0.366948312 hsa-miR-16_st 14.00993192 0.495935174 hsa-miR-936_st 11.18337823 0.376217588 hsa-miR-181c-star_st 7.295464938 0.777034 hsa-miR-379_st 6.004420442 1.061999537 hsa-miR-370_st 11.04457054 0.439061503 hsa-miR-541_st 8.627429045 0.391486639 hsa-miR-518c-star_st 8.784237219 0.433117209 hsa-miR-487b_st 9.838051 0.858903274 hsa-miR-182-star_st 3.526728094 0.36626621 hsa-miR-3121_st 7.79081877 1.313522241 hsa-miR-3190-5p_st 10.38692172 0.418188044 hsa-miR-1203_st 9.181036937 0.521755032 hsa-miR-185_st 9.651865117 0.617785517 hsa-miR-185-star_st 9.507002775 0.523779387 hsa-miR-4317_st 9.89812612 0.580304623 hsa-miR-186-star_st 2.841188382 0.209005359 hsa-miR-187_st 5.728403231 1.088321407 hsa-miR-4257_st 12.39086919 0.544638489 hsa-miR-188-3p_st 4.835018522 0.65645238 hsa-miR-1184_st 5.089481247 0.381829557 hsa-miR-18a_st 5.197086592 0.573671424 hsa-miR-18a-star_st 5.172481891 0.544288689 hsa-miR-3140_st 5.315162277 0.58217134 hsa-miR-18b-star_st 4.259578437 0.37094237 hsa-miR-190_st 2.586472186 0.387319395 hsa-miR-601_st 5.937820377 0.663337894 hsa-miR-1909_st 14.73085745 0.334572678 hsa-miR-342-5p_st 5.975120939 1.136654656 hsa-miR-575_st 13.47370293 0.845807846 hsa-miR-885-5p_st 7.266016707 0.897742696 hsa-miR-300_st 6.150257496 0.434656204 hsa-miR-1911_st 4.238923243 0.337890538 hsa-miR-1911-star_st 5.614210775 0.424510492 hsa-miR-1912_st 4.585932615 0.394089715 hsa-miR-4266_st 6.953943916 0.383669601 hsa-miR-1914_st 6.003099294 0.457417748 hsa-miR-3190-3p_st 11.0379916 0.522051223 hsa-miR-618_st 3.961741747 0.347698399 hsa-miR-1276_st 7.347252958 0.631808791 hsa-miR-191-star_st 6.558696267 0.499301279 hsa-miR-1258_st 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hsa-miR-576-3p_st 4.691598101 0.539145273 hsa-miR-576-5p_st 4.045272561 0.621427033 hsa-miR-577_st 3.215188096 0.458326752 hsa-miR-578_st 4.175572717 0.310672743 hsa-miR-579_st 3.355939711 0.296231116 hsa-miR-580_st 3.177991807 0.31242122 hsa-miR-191_st 12.8294704 0.745669275 hsa-miR-582-3p_st 3.891236637 0.247609148 hsa-miR-582-5p_st 3.48072578 0.993854804 hsa-miR-1915_st 15.80445781 0.41458079 hsa-let-7c_st 14.33965474 0.56142438 hsa-miR-585_st 3.676706595 0.325242062 hsa-miR-586_st 3.115435748 0.330633826 hsa-miR-324-5p_st 9.334038374 0.889638423 hsa-miR-588_st 5.189310898 0.4139754 hsa-miR-589_st 5.045287429 0.464812176 hsa-miR-589-star_st 5.168989742 0.485859056 hsa-miR-188-5p_st 8.4050448 0.611669083 hsa-miR-103_st 13.09210474 0.669298536 hsa-miR-591_st 4.037498622 0.436401955 hsa-miR-592_st 3.480573401 0.662663833 hsa-miR-593_st 6.042201039 0.333899469 hsa-miR-23b_st 14.57717778 0.57446395 hsa-miR-595_st 7.02794467 0.335397875 hsa-miR-99a_st 12.61401811 1.232242591 hsa-miR-15b_st 10.90719793 1.257104115 hsa-miR-135b_st 4.372410287 0.939107468 hsa-miR-599_st 3.058379929 0.519899617 hsa-miR-600_st 7.072488005 0.637333381 hsa-miR-107_st 13.00670539 0.626160471 hsa-miR-602_st 14.05079982 0.282034361 hsa-miR-603_st 2.98214102 0.256461477 hsa-miR-3065-5p_st 4.563223362 1.440582635 hsa-miR-605_st 5.286786379 0.483434825 hsa-miR-24_st 13.50428429 0.663999897 hsa-miR-607_st 3.448105584 0.247464955 hsa-miR-608_st 9.435447562 0.259115932 hsa-miR-609_st 3.783826276 0.312615116 hsa-miR-3196_st 15.80552392 0.415737295 hsa-miR-26b_st 13.06592106 0.688443983 hsa-miR-28-5p_st 10.02122476 0.489418533 hsa-miR-613_st 4.030864406 0.294413709 hsa-miR-338-3p_st 5.325298242 1.493243358 hsa-miR-615-3p_st 7.380334768 0.463290678 hsa-miR-454_st 7.163103195 0.858902895 hsa-miR-616_st 8.053792417 0.511570269 hsa-miR-151-5p_st 12.28749225 0.463419016 hsa-miR-617_st 7.159992296 0.873521986 hsa-miR-128_st 9.351785733 1.053477289 hsa-miR-619_st 4.486472078 0.366900595 hsa-miR-620_st 3.64624706 0.300151884 hsa-miR-621_st 4.016026495 0.382657472 hsa-let-7b_st 13.31874955 1.009507341 hsa-miR-623_st 9.873685431 0.216815663 hsa-miR-624_st 4.01181992 0.285100232 hsa-miR-624-star_st 4.332323405 0.72405747 hsa-miR-183_st 7.731525357 1.296542305 hsa-miR-30b_st 13.32721506 0.373900135 hsa-miR-626_st 3.293919864 0.372581198 hsa-miR-627_st 3.304561749 0.441759495 hsa-miR-628-3p_st 10.99900052 1.292811213 hsa-miR-31-star_st 4.468161718 3.069041371 hsa-miR-218-1-star_st 3.406688503 0.403448151 hsa-miR-629-star_st 6.135671925 0.516401266 hsa-miR-630_st 8.367283405 0.872774703 hsa-miR-631_st 7.292503851 1.004234432 hsa-miR-632_st 4.466774854 0.576344616 hsa-miR-633_st 3.189727739 0.328839765 hsa-miR-634_st 5.785665723 0.972531844 hsa-miR-635_st 5.061945763 0.613134614 hsa-miR-203_st 8.134155576 2.061222705 hsa-miR-331-3p_st 10.5128864 0.699834644 hsa-miR-125b_st 14.54584858 0.60575746 hsa-let-7i_st 13.62034015 0.724742139 hsa-miR-640_st 5.807272353 0.312804794 hsa-miR-641_st 4.84236123 0.6273217 hsa-miR-642_st 4.005526941 0.34892113 hsa-miR-29b_st 12.78590779 0.922218066 hsa-miR-122_st 4.401655648 0.433064488 hsa-miR-645_st 4.528626248 0.244132105 hsa-miR-646_st 3.982571016 0.442295364 hsa-miR-647_st 4.796297255 0.303511173 hsa-miR-648_st 8.681869631 0.393242871 hsa-miR-649_st 4.021342918 0.701149587 hsa-miR-182_st 10.58249999 1.08710128 hsa-miR-651_st 3.129403256 0.352182192 hsa-miR-652_st 7.877508626 0.768591455 hsa-miR-653_st 3.070031603 0.300380206 hsa-miR-654-3p_st 4.719034401 1.653691056 hsa-miR-374b_st 8.311444342 0.685749139 hsa-miR-130a_st 11.69154937 0.686214041 hsa-miR-656_st 3.578491785 0.342033843 hsa-miR-657_st 4.164262545 0.436292898 hsa-miR-658_st 12.09008412 0.399339252 hsa-miR-99b_st 11.72051 0.810486917 hsa-miR-660_st 8.42891977 1.067247336 hsa-miR-661_st 7.090628412 0.376992477 hsa-miR-30e-star_st 10.47292099 1.143237493 hsa-miR-663_st 15.60499297 0.358699166 hsa-miR-663b_st 10.23191101 0.413480867 hsa-miR-664_st 7.889870823 0.787406697 hsa-miR-664-star_st 10.11457456 0.828182343 hsa-miR-30d_st 13.04724431 0.466532488 hsa-miR-668_st 8.571288609 0.575571482 hsa-miR-670_st 5.160797226 0.554286761 hsa-miR-671-3p_st 7.499483176 0.524564387 hsa-miR-671-5p_st 12.25676283 0.232774365 hsa-miR-30a-star_st 10.82252443 1.154206027 hsa-miR-675-star_st 5.112394025 0.520294656 hsa-miR-148b_st 9.93977646 0.771471228 hsa-miR-708_st 7.940079113 1.564941682 hsa-miR-708-star_st 4.296320901 0.353886218 hsa-miR-221-star_st 6.924257339 1.686940568 hsa-let-7e_st 13.14530741 0.696323234 hsa-miR-7-1-star_st 6.585159303 0.856104437 hsa-miR-27b_st 12.98670716 0.447334038 hsa-miR-34a_st 9.752045866 1.354852932 hsa-miR-744_st 14.33236852 0.381917587 hsa-miR-744-star_st 5.186310427 0.441038113 hsa-miR-92b_st 9.616842204 1.445623964 hsa-miR-759_st 3.293874756 0.421380174 hsa-miR-760_st 10.29890681 0.492749846 hsa-miR-92a_st 11.61845971 1.194701029 hsa-miR-335_st 9.99805058 0.847187434 hsa-miR-96_st 8.153083944 1.206737605 hsa-miR-95_st 8.788939753 1.007518409 hsa-miR-766_st 7.538910686 0.345905123 hsa-miR-767-3p_st 4.202930904 0.226676867 hsa-miR-767-5p_st 4.36764344 0.449657305 hsa-miR-98_st 10.65074756 0.808305776 hsa-miR-769-5p_st 7.394684018 0.807342748 hsa-miR-770-5p_st 7.799338826 0.544174665 hsa-miR-802_st 2.910978116 0.287417396 hsa-miR-34b-star_st 6.452815734 1.229679145 hsa-miR-581_st 2.69005347 0.622170491 hsa-miR-181d_st 9.497680111 0.802187112 hsa-miR-875-5p_st 2.866422213 0.352115979 hsa-miR-876-3p_st 3.22502718 0.35181295 hsa-miR-876-5p_st 2.636975274 0.407181072 hsa-miR-151-3p_st 9.928450931 0.511242956 hsa-miR-877-star_st 5.985272902 0.662343654 hsa-miR-885-3p_st 13.33552778 0.521981099 hsa-miR-200c_st 13.89146666 0.446453296 hsa-miR-429_st 5.835742762 1.814180085 hsa-miR-886-5p_st 12.83676585 0.879179868 hsa-miR-224_st 8.047711461 1.374030683 hsa-miR-888_st 3.480056641 0.570579776 hsa-miR-4321_st 9.605216576 0.455188582 hsa-miR-889_st 3.416494703 0.402710511 hsa-miR-181b_st 10.7791005 0.792412486 hsa-miR-891a_st 6.959925918 0.629228746 hsa-miR-891b_st 3.941669022 0.488002907 hsa-miR-892a_st 4.368166152 0.842683271 hsa-miR-892b_st 4.64473837 0.447772897 hsa-miR-9_st 2.97576649 0.324639663 hsa-miR-222_st 12.34217148 1.918798705 hsa-miR-141_st 10.47024842 0.725536346 hsa-miR-221_st 12.56379474 1.641533028 hsa-miR-924_st 3.899667356 0.229009897 hsa-miR-181a_st 12.46367044 1.097214185 hsa-miR-181c_st 9.310571105 1.052647573 hsa-miR-4324_st 10.65482238 1.178890301 hsa-miR-125a-5p_st 13.96720564 1.047507597 hsa-miR-92b-star_st 14.67935209 0.264384316 hsa-miR-3195_st 12.69957006 0.4431018 hsa-miR-3137_st 10.94948284 0.589448822 hsa-miR-934_st 5.316019706 0.606167733 hsa-miR-935_st 4.766481857 0.744618673 hsa-miR-551b_st 4.959840516 2.498427895 hsa-miR-937_st 5.441795028 0.760816242 hsa-miR-938_st 4.901024337 0.402229406 hsa-miR-939_st 13.19242244 0.278406151 hsa-miR-7-2-star_st 6.461874071 1.823716389 hsa-miR-146b-5p_st 10.72460716 2.254121832 hsa-miR-941_st 5.8472898 0.527232251 hsa-miR-942_st 3.132337606 0.448407639 hsa-miR-200a_st 9.063667443 2.478819937 hsa-miR-944_st 3.475952551 0.505791777 hsa-miR-7_st 7.569002947 3.423226794 hsa-miR-375_st 5.973873271 0.890249857 hsa-miR-96-star_st 4.54741107 0.550003676 hsa-miR-424_st 9.200903135 1.485182236 hsa-miR-181a-2-star_st 8.649746134 1.060700412 hsa-miR-200b_st 10.36920802 2.416748349 hsa-miR-146b-3p_st 5.411185853 1.972804791 hsa-miR-99b-star_st 7.752210153 0.491251051 hsa-miR-9-star_st 4.077600376 0.578675413 Log2 Diff Fold change T-test (Malignant vs (Malignant vs (Malignant vs Sample Name Benign) Benign) Benign) p < 0.05 hsa-miR-150_st 0.222052605 1.2 0.860205599 0 hsa-let-7a-2-star_st 0.380521359 1.3 0.021585956 1 hsa-let-7a-star_st 0.173921871 1.1 0.485965006 0 hsa-miR-513b_st −0.942170264 1.9 0.035004076 1 hsa-let-7b-star_st 0.303508552 1.2 0.052070371 0 hsa-miR-593-star_st −0.844203562 1.8 0.042498824 1 hsa-let-7c-star_st 0.160682635 1.1 0.242588862 0 hsa-miR-516a-5p_st −0.7087716 1.6 0.019004175 1 hsa-miR-142-5p_st 0.864378114 1.8 0.208465715 0 hsa-miR-650_st −0.659154321 1.6 0.003369901 1 hsa-miR-513c_st −0.773527809 1.7 0.02662366 1 hsa-miR-761_st −0.436015764 1.4 0.282013089 0 hsa-let-7f-1-star_st −0.056873642 1.0 0.994754986 0 hsa-miR-513a-5p_st −0.710774544 1.6 0.055858062 0 hsa-miR-654-5p_st −0.874558595 1.8 0.002216159 1 hsa-let-7g-star_st 0.187885637 1.1 0.162150496 0 hsa-miR-3163_st −0.615485135 1.5 0.014703979 1 hsa-let-7i-star_st 0.975051153 2.0 9.84706E−05 1 hsa-miR-3165_st −0.716115742 1.6 0.024092301 1 hsa-miR-3194_st −0.71116551 1.6 0.002778842 1 hsa-miR-100-star_st 0.147806712 1.1 0.679726515 0 hsa-miR-4251_st −0.555906938 1.5 0.046641914 1 hsa-miR-101-star_st 0.396387368 1.3 0.216028834 0 hsa-miR-922_st −0.383665861 1.3 0.120758822 0 hsa-miR-103-2-star_st 0.409014576 1.3 0.453881694 0 hsa-miR-155_st 0.657110316 1.6 0.068541709 0 hsa-miR-105_st −0.199067097 1.1 0.039953133 1 hsa-miR-127-5p_st −0.480881806 1.4 0.197776991 0 hsa-miR-1286_st −0.361311766 1.3 0.405657897 0 hsa-miR-106a-star_st 0.10908219 1.1 0.958945377 0 hsa-miR-890_st −0.175051975 1.1 0.617679044 0 hsa-miR-3126-5p_st −0.880040173 1.8 0.002258153 1 hsa-miR-489_st −0.695721922 1.6 0.038958849 1 hsa-miR-10a_st 0.893140031 1.9 0.007144861 1 hsa-miR-10a-star_st 0.034602902 1.0 0.704138675 0 hsa-miR-10b_st 1.236475278 2.4 0.000452127 1 hsa-miR-10b-star_st 0.239974108 1.2 0.134880405 0 hsa-miR-1178_st −0.22990198 1.2 0.144231856 0 hsa-miR-1179_st 0.179450609 1.1 0.260135043 0 hsa-miR-1180_st −0.3957419 1.3 0.001411079 1 hsa-miR-1181_st −0.289322804 1.2 0.140870772 0 hsa-miR-3138_st −0.792844548 1.7 0.001393198 1 hsa-miR-220c_st −0.46156797 1.4 0.043585179 1 hsa-miR-510_st −0.761174501 1.7 0.010677787 1 hsa-miR-1185_st −0.059965152 1.0 0.485006514 0 hsa-miR-1193_st −0.293261361 1.2 0.018262307 1 hsa-miR-1197_st 0.005404133 1.0 0.964332774 0 hsa-miR-1200_st 0.038508566 1.0 0.956740049 0 hsa-miR-1201_st 0.536104713 1.5 0.102280969 0 hsa-miR-1202_st −0.579908533 1.5 0.000136312 1 hsa-miR-30c-1-star_st −0.683488343 1.6 0.015959194 1 hsa-miR-1204_st −0.234005785 1.2 0.196014043 0 hsa-miR-1205_st −0.159132582 1.1 0.154185041 0 hsa-miR-1206_st 0.027885919 1.0 0.959626916 0 hsa-miR-1207-3p_st −0.109163301 1.1 0.34613346 0 hsa-miR-1207-5p_st −0.461218285 1.4 0.000299713 1 hsa-miR-1208_st −0.810294521 1.8 7.59262E−05 1 hsa-miR-622_st −0.540947195 1.5 0.078427604 0 hsa-miR-1224-3p_st −0.010074347 1.0 0.992062807 0 hsa-miR-2116_st −0.514250548 1.4 0.033503517 1 hsa-miR-1225-3p_st −0.172683387 1.1 0.547414109 0 hsa-miR-1225-5p_st −0.517668035 1.4 0.000801489 1 hsa-miR-1226_st −0.193009106 1.1 0.14831534 0 hsa-miR-30b-star_st −0.659411627 1.6 0.011099023 1 hsa-miR-1227_st 0.08972765 1.1 0.977701762 0 hsa-miR-1295_st −0.52190788 1.4 0.003859278 1 hsa-miR-1228-star_st −0.301796436 1.2 0.066221826 0 hsa-miR-20b_st 1.450315379 2.7 0.001914349 1 hsa-miR-122-star_st 0.033323905 1.0 0.637196006 0 hsa-miR-1231_st −0.539214969 1.5 0.000314227 1 hsa-miR-1233_st −0.368931947 1.3 0.033666673 1 hsa-miR-524-5p_st −0.194758584 1.1 0.442305294 0 hsa-miR-1236_st −0.030539642 1.0 0.847291014 0 hsa-miR-873_st −0.317384348 1.2 0.096861262 0 hsa-miR-1238_st −0.245755821 1.2 0.276479632 0 hsa-miR-124_st −0.149975326 1.1 0.410583674 0 hsa-miR-1243_st −0.007320981 1.0 0.940745356 0 hsa-miR-1244_st 0.120529402 1.1 0.320982615 0 hsa-miR-1245_st −0.072612339 1.1 0.459296555 0 hsa-miR-3122_st −0.838109462 1.8 0.000229025 1 hsa-miR-134_st −0.825685919 1.8 0.000221367 1 hsa-miR-1248_st −0.050695798 1.0 0.858578269 0 hsa-miR-146a_st 1.703691806 3.3 0.000239942 1 hsa-miR-124-star_st −0.243733207 1.2 0.060226873 0 hsa-miR-1250_st −0.607792994 1.5 0.003333519 1 hsa-miR-764_st −0.318323323 1.2 0.204880907 0 hsa-miR-1252_st 0.205286327 1.2 0.196771547 0 hsa-miR-223_st 0.973175877 2.0 0.065579732 0 hsa-miR-34c-3p_st −0.652186785 1.6 0.029729915 1 hsa-miR-1255a_st 0.131786979 1.1 0.817077716 0 hsa-miR-1255b_st −0.252264174 1.2 0.333691681 0 hsa-miR-1256_st 0.107340868 1.1 0.731503578 0 hsa-miR-1257_st 0.019477962 1.0 0.988403769 0 hsa-miR-199b-5p_st −0.21529813 1.2 0.774554017 0 hsa-miR-1259_st 0.182349168 1.1 0.52426746 0 hsa-miR-492_st −0.642006592 1.6 0.006480247 1 hsa-miR-3132_st −0.584728046 1.5 0.0386641 1 hsa-miR-516b_st −0.561909372 1.5 0.014122583 1 hsa-miR-4294_st −0.701213945 1.6 0.003054414 1 hsa-miR-125b-2-star_st −0.262893484 1.2 0.400570054 0 hsa-miR-126_st 0.506142921 1.4 0.068976141 0 hsa-miR-198_st −0.700349187 1.6 0.004579127 1 hsa-miR-3191_st −0.477486945 1.4 0.119742016 0 hsa-miR-1261_st −0.516847212 1.4 0.147890143 0 hsa-miR-1262_st −0.109808362 1.1 0.395853993 0 hsa-miR-1263_st 0.113544564 1.1 0.54420963 0 hsa-miR-1264_st 0.063831943 1.0 0.779008887 0 hsa-miR-1265_st 0.173811188 1.1 0.140514249 0 hsa-miR-2114-star_st −0.503348396 1.4 0.091566835 0 hsa-miR-1267_st −0.257862054 1.2 0.024872184 1 hsa-miR-1268_st −0.487502765 1.4 0.002166064 1 hsa-miR-1269_st −0.37033274 1.3 0.04866386 1 hsa-miR-509-5p_st −0.459679404 1.4 0.044420536 1 hsa-miR-1270_st −0.272207857 1.2 0.033363679 1 hsa-miR-1271_st −0.272891287 1.2 0.124529908 0 hsa-miR-4303_st −0.499112595 1.4 0.044577217 1 hsa-miR-1273_st −0.487899233 1.4 0.088223736 0 hsa-miR-583_st −0.237961517 1.2 0.405576105 0 hsa-miR-1273d_st −0.263304276 1.2 0.208253538 0 hsa-miR-127-3p_st 0.465906015 1.4 0.191036356 0 hsa-miR-522-star_st −0.56698063 1.5 0.021536929 1 hsa-miR-214-star_st 0.159707729 1.1 0.375439189 0 hsa-miR-184_st −0.554802057 1.5 0.092597264 0 hsa-miR-614_st −0.316560945 1.2 0.176367012 0 hsa-miR-526b_st −0.346183854 1.3 0.120643184 0 hsa-miR-1277_st 0.216959641 1.2 0.611342978 0 hsa-miR-1278_st 0.229200297 1.2 0.316218283 0 hsa-miR-1279_st 0.116000432 1.1 0.568339756 0 hsa-miR-409-3p_st −0.119256413 1.1 0.271379705 0 hsa-miR-199a-5p_st 0.266041662 1.2 0.368234862 0 hsa-miR-1281_st −0.376508269 1.3 0.015708011 1 hsa-miR-1282_st −0.07627604 1.1 0.635598922 0 hsa-miR-33b-star_st −0.536314174 1.5 0.003531689 1 hsa-miR-1284_st −0.043979139 1.0 0.453609027 0 hsa-miR-1253_st −0.149617083 1.1 0.40442235 0 hsa-miR-584_st −0.595345983 1.5 0.00107128 1 hsa-miR-1287_st −0.005456183 1.0 0.606367673 0 hsa-miR-15a_st 1.890662707 3.7 4.99062E−05 1 hsa-miR-1289_st −0.079816411 1.1 0.628434489 0 hsa-miR-1290_st 0.032634716 1.0 0.499675865 0 hsa-miR-2117_st −0.305112668 1.2 0.015940351 1 hsa-miR-1292_st −0.611743889 1.5 0.000848166 1 hsa-miR-1293_st −0.51026792 1.4 0.002466981 1 hsa-miR-129-3p_st 0.383345945 1.3 0.19794232 0 hsa-miR-520d-5p_st −0.412973182 1.3 0.119864002 0 hsa-miR-526a_st −0.298084351 1.2 0.258970121 0 hsa-miR-129-5p_st −0.66296401 1.6 0.000187048 1 hsa-miR-1254_st −0.701761114 1.6 0.000549994 1 hsa-miR-1297_st −0.012651212 1.0 0.596075545 0 hsa-miR-1298_st 0.055368649 1.0 0.670207362 0 hsa-miR-1299_st −0.150683798 1.1 0.456002363 0 hsa-miR-129-star_st 0.136663049 1.1 0.836867788 0 hsa-miR-1301_st −0.301427895 1.2 0.017730122 1 hsa-miR-19b_st 1.38730385 2.6 0.002656394 1 hsa-miR-1303_st −0.404276523 1.3 0.057547753 0 hsa-miR-1304_st −0.312528984 1.2 0.141834548 0 hsa-miR-1305_st −0.063087622 1.0 0.378970808 0 hsa-miR-550_st −0.496093635 1.4 0.007154735 1 hsa-miR-1307_st −0.554199521 1.5 0.001022818 1 hsa-miR-1308_st 0.310171917 1.2 0.021134089 1 hsa-miR-4291_st 0.769804555 1.7 0.002661911 1 hsa-miR-130a-star_st 0.006223946 1.0 0.589744809 0 hsa-miR-130b_st 0.417136587 1.3 0.271794998 0 hsa-miR-130b-star_st 0.275304414 1.2 0.422166352 0 hsa-miR-921_st −0.671560214 1.6 0.004421654 1 hsa-miR-520a-5p_st −0.264381023 1.2 0.07023584 0 hsa-miR-711_st −0.565600546 1.5 0.01609509 1 hsa-miR-1323_st −0.640389031 1.6 0.00808267 1 hsa-miR-1324_st 0.135696574 1.1 0.548358212 0 hsa-miR-490-3p_st −0.435769493 1.4 0.056015659 0 hsa-miR-718_st −0.599517099 1.5 0.004795659 1 hsa-miR-133b_st 0.410552029 1.3 0.236027744 0 hsa-miR-431-star_st −0.689803635 1.6 0.000147175 1 hsa-miR-552_st −0.449931627 1.4 0.060962583 0 hsa-miR-28-3p_st 0.794466886 1.7 0.009148888 1 hsa-miR-4265_st −0.711203667 1.6 0.000455925 1 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1 hsa-miR-1468_st −0.07967708 1.1 0.918650785 0 hsa-miR-1469_st −0.098271541 1.1 0.53146079 0 hsa-miR-1973_st −0.618155465 1.5 0.029852895 1 hsa-miR-3154_st −0.610121669 1.5 0.001421936 1 hsa-miR-148a-star_st 0.152713606 1.1 0.555555741 0 hsa-miR-92a-1-star_st −0.626094587 1.5 0.001472805 1 hsa-miR-147_st −0.1478104 1.1 0.22943945 0 hsa-miR-194-star_st −0.635308948 1.6 0.014306649 1 hsa-miR-1471_st −0.765524331 1.7 0.00263111 1 hsa-miR-147b_st −0.049319243 1.0 0.766943913 0 hsa-miR-148a_st 0.47072386 1.4 0.185956664 0 hsa-miR-4299_st −0.583862034 1.5 0.052157931 0 hsa-miR-135a-star_st −0.682970357 1.6 0.001086185 1 hsa-miR-612_st −0.641610843 1.6 0.004947708 1 hsa-miR-1321_st −0.496037076 1.4 0.064938111 0 hsa-miR-149-star_st −0.243117708 1.2 0.10108445 0 hsa-miR-604_st −0.423099533 1.3 0.127502863 0 hsa-miR-150-star_st −0.520200751 1.4 0.001726856 1 hsa-miR-125b-1-star_st −0.52408129 1.4 0.001997452 1 hsa-miR-1183_st −0.548470484 1.5 0.002313088 1 hsa-miR-152_st 0.212617324 1.2 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hsa-miR-199b-3p_st 0.116752945 1.1 0.618217432 0 hsa-miR-639_st −0.624796364 1.5 0.001615785 1 hsa-miR-1909-star_st −0.214253172 1.2 0.212847481 0 hsa-miR-19a-star_st 0.011234424 1.0 0.687240996 0 hsa-miR-29c-star_st 1.108321756 2.2 0.000152931 1 hsa-miR-940_st −0.53305217 1.4 0.004700134 1 hsa-miR-19b-2-star_st −0.061734427 1.0 0.448702321 0 hsa-miR-4269_st −0.453807676 1.4 0.064105056 0 hsa-miR-200a-star_st 0.268742079 1.2 0.097169899 0 hsa-miR-1182_st −0.641650097 1.6 0.000304427 1 hsa-miR-518f-star_st −0.233621327 1.2 0.451251355 0 hsa-miR-92a-2-star_st −0.515299774 1.4 0.081651463 0 hsa-miR-200c-star_st 0.208084422 1.2 0.108188541 0 hsa-miR-202_st −0.491667701 1.4 0.006502044 1 hsa-miR-202-star_st 0.098346294 1.1 0.677482857 0 hsa-miR-1914-star_st −0.555736279 1.5 0.001401361 1 hsa-miR-204_st −1.399312568 2.6 0.051996525 0 hsa-miR-665_st −0.442075084 1.4 0.011902631 1 hsa-miR-2052_st 0.208547023 1.2 0.351417808 0 hsa-miR-2053_st 0.072093581 1.1 0.738327491 0 hsa-miR-2054_st 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1.3 0.003912012 1 hsa-miR-214_st −0.170059616 1.1 0.719896882 0 hsa-miR-1825_st −0.225066876 1.2 0.135432485 0 hsa-miR-215_st 0.470488353 1.4 0.442331812 0 hsa-miR-216a_st −0.060844105 1.0 0.575162441 0 hsa-miR-195-star_st −0.023958939 1.0 0.90489808 0 hsa-miR-217_st 0.17185971 1.1 0.176433368 0 hsa-miR-23a-star_st −0.428590827 1.3 0.031783886 1 hsa-miR-25-star_st −0.551507645 1.5 0.005143138 1 hsa-miR-218-2-star_st −0.175244052 1.1 0.271102398 0 hsa-miR-1273c_st −0.40064583 1.3 0.106881156 0 hsa-miR-219-2-3p_st −0.401983392 1.3 0.051868979 0 hsa-miR-637_st −0.653117025 1.6 0.00044811 1 hsa-miR-21-star_st 0.601654482 1.5 0.009817713 1 hsa-miR-22_st 0.796029353 1.7 0.014627165 1 hsa-miR-220a_st 0.24996554 1.2 0.096866346 0 hsa-miR-220b_st 0.250309064 1.2 0.123739258 0 hsa-miR-219-1-3p_st −0.281923306 1.2 0.024503465 1 hsa-miR-4316_st −0.480876791 1.4 0.001533793 1 hsa-miR-877_st −0.617502542 1.5 6.54248E−05 1 hsa-miR-636_st −0.49113505 1.4 0.006070819 1 hsa-miR-3177_st −0.657881548 1.6 0.000298485 1 hsa-miR-1249_st −0.046298628 1.0 0.848075712 0 hsa-miR-223-star_st 0.401799043 1.3 0.351859418 0 hsa-miR-1224-5p_st −0.6165197 1.5 6.71237E−06 1 hsa-miR-564_st −0.565311252 1.5 0.001267526 1 hsa-miR-2276_st −0.648220232 1.6 0.000721201 1 hsa-miR-2277_st −0.352678406 1.3 0.048673567 1 hsa-miR-2278_st −0.261848413 1.2 0.162059884 0 hsa-miR-22-star_st 1.062323014 2.1 0.013932188 1 hsa-miR-2355_st −0.093261401 1.1 0.290771967 0 hsa-miR-769-3p_st −0.489694573 1.4 0.037094124 1 hsa-miR-1913_st −0.362021722 1.3 0.084799625 0 hsa-miR-1237_st −0.275433027 1.2 0.171918458 0 hsa-miR-1275_st −0.467154658 1.4 0.007809435 1 hsa-miR-30a_st 0.994482288 2.0 0.00064785 1 hsa-miR-20b-star_st −0.270574253 1.2 0.01738856 1 hsa-miR-24-2-star_st 1.091725483 2.1 8.70722E−05 1 hsa-miR-3173_st −0.55033887 1.5 0.007085336 1 hsa-miR-3148_st −0.242944072 1.2 0.148633312 0 hsa-miR-4271_st −0.637545881 1.6 0.000425937 1 hsa-miR-659_st −0.492990393 1.4 0.00751997 1 hsa-miR-26a-2-star_st 0.145485123 1.1 0.900453716 0 hsa-miR-1228_st −0.472767718 1.4 0.012009445 1 hsa-miR-26b-star_st 0.868149649 1.8 0.003099131 1 hsa-miR-3174_st −0.160780973 1.1 0.55094482 0 hsa-miR-27a-star_st 0.108915254 1.1 0.650286341 0 hsa-miR-1285_st −0.359126421 1.3 0.0367001 1 hsa-miR-483-5p_st −0.448338126 1.4 0.026117133 1 hsa-miR-1306_st −0.364416168 1.3 0.003497236 1 hsa-miR-431_st 0.330128391 1.3 0.344039948 0 hsa-miR-765_st −0.417507121 1.3 0.024742559 1 hsa-miR-2909_st 0.204046548 1.2 0.213913136 0 hsa-miR-296-3p_st −0.529698688 1.4 0.00081683 1 hsa-miR-296-5p_st 0.205448097 1.2 0.435700668 0 hsa-miR-297_st −0.23324311 1.2 0.177544416 0 hsa-miR-323b-5p_st −0.158119612 1.1 0.78811908 0 hsa-miR-299-3p_st −0.205631118 1.2 0.503522303 0 hsa-miR-299-5p_st 0.092756749 1.1 0.971021124 0 hsa-miR-487a_st 0.362171988 1.3 0.046640739 1 hsa-miR-29a-star_st 0.038098103 1.0 0.846465338 0 hsa-miR-625_st 0.143664769 1.1 0.553203594 0 hsa-miR-611_st −0.347599942 1.3 0.139156229 0 hsa-miR-3186-3p_st 0.018134799 1.0 0.636818552 0 hsa-miR-1294_st −0.241617182 1.2 0.027633053 1 hsa-miR-3147_st −0.616379964 1.5 0.000114432 1 hsa-miR-4285_st −0.6688107 1.6 0.003880846 1 hsa-miR-125a-3p_st −0.338305912 1.3 0.025111823 1 hsa-miR-301b_st 0.157525213 1.1 0.960904014 0 hsa-miR-302a_st 0.044285746 1.0 0.989740982 0 hsa-miR-518e-star_st −0.314112434 1.2 0.235754188 0 hsa-miR-302b_st 0.04206039 1.0 0.863508675 0 hsa-miR-302b-star_st −0.193906932 1.1 0.14514732 0 hsa-miR-302c_st −0.020124281 1.0 0.65422486 0 hsa-miR-302c-star_st −0.564911045 1.5 0.03475367 1 hsa-miR-302d_st −0.038896466 1.0 0.39452106 0 hsa-miR-302d-star_st −0.27293483 1.2 0.533517783 0 hsa-miR-302e_st 0.137372123 1.1 0.646575145 0 hsa-miR-302f_st 0.174225731 1.1 0.322120676 0 hsa-miR-3065-3p_st 0.077698858 1.1 0.824427886 0 hsa-miR-3130-5p_st −0.301395577 1.2 0.08069423 0 hsa-miR-3074_st −0.139090182 1.1 0.353262151 0 hsa-miR-1226-star_st −0.554051488 1.5 0.000251982 1 hsa-miR-3180-5p_st −0.361808103 1.3 0.053512943 0 hsa-miR-1229_st 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−0.273666886 1.2 0.06017569 0 hsa-miR-1296_st −0.132617848 1.1 0.827943007 0 hsa-miR-3127_st −0.593205109 1.5 0.010446767 1 hsa-miR-3128_st −0.057078556 1.0 0.372803813 0 hsa-miR-3129_st 0.073120444 1.1 0.826359967 0 hsa-miR-3130-3p_st −0.571898061 1.5 0.008660477 1 hsa-miR-105-star_st −0.169349295 1.1 0.105967677 0 hsa-miR-3131_st −0.481316892 1.4 0.008039702 1 hsa-miR-4255_st −0.175740033 1.1 0.051477643 0 hsa-miR-3133_st −0.123603968 1.1 0.449049667 0 hsa-miR-3134_st 0.019528486 1.0 0.786674222 0 hsa-miR-3135_st −0.42079135 1.3 0.023316049 1 hsa-miR-3136_st −0.357937798 1.3 0.010065854 1 hsa-miR-19b-1-star_st 0.244734498 1.2 0.345497789 0 hsa-miR-1247_st −0.521780044 1.4 0.027012999 1 hsa-miR-3139_st 0.05465175 1.0 0.949090377 0 hsa-miR-596_st −0.284551104 1.2 0.105768314 0 hsa-miR-3141_st −0.482399794 1.4 0.003310383 1 hsa-miR-3142_st 0.107763773 1.1 0.592268433 0 hsa-miR-1302_st −0.165059715 1.1 0.107099038 0 hsa-miR-3144-3p_st −0.044829172 1.0 0.502897584 0 hsa-miR-3144-5p_st −0.105193877 1.1 0.671849399 0 hsa-miR-3145_st −0.108921409 1.1 0.404567597 0 hsa-miR-3146_st −0.21066893 1.2 0.130181783 0 hsa-miR-346_st −0.301595597 1.2 0.134822409 0 hsa-miR-4256_st −0.284374753 1.2 0.004273465 1 hsa-miR-3149_st 0.087608242 1.1 0.812963268 0 hsa-miR-3150_st −0.353802881 1.3 0.12042593 0 hsa-miR-3151_st −0.555863627 1.5 0.003036503 1 hsa-miR-1470_st −0.218773405 1.2 0.166612242 0 hsa-miR-3153_st −0.456075181 1.4 0.073992293 0 hsa-miR-514_st 0.105466687 1.1 0.829731118 0 hsa-miR-3175_st −0.150334576 1.1 0.356003476 0 hsa-miR-3156_st −0.038231114 1.0 0.797486007 0 hsa-miR-504_st 0.058318416 1.0 0.52905772 0 hsa-miR-3158_st −0.125234901 1.1 0.238811109 0 hsa-miR-3159_st −0.229131179 1.2 0.124561401 0 hsa-miR-3160_st −0.139578186 1.1 0.377261574 0 hsa-miR-3161_st −0.191560704 1.1 0.708789425 0 hsa-miR-3162_st −0.513433751 1.4 0.000380219 1 hsa-miR-1234_st −0.257626876 1.2 0.122873601 0 hsa-miR-3164_st −0.667353407 1.6 0.003387283 1 hsa-miR-516b-star_st 0.23175777 1.2 0.089270532 0 hsa-miR-3166_st 0.136464153 1.1 0.221150448 0 hsa-miR-4327_st −0.646494192 1.6 6.73331E−05 1 hsa-miR-3168_st 0.155093847 1.1 0.470633398 0 hsa-miR-3169_st −0.19172817 1.1 0.030523306 1 hsa-miR-3170_st −0.32213791 1.3 0.149901365 0 hsa-miR-3171_st 0.044877251 1.0 0.770472338 0 hsa-miR-3172_st 0.316078382 1.2 0.042390621 1 hsa-miR-374b-star_st 0.324945805 1.3 0.106535636 0 hsa-miR-34c-5p_st 0.363927256 1.3 0.082737117 0 hsa-miR-758_st 0.033572974 1.0 0.770637393 0 hsa-miR-3176_st −0.089780423 1.1 0.783447529 0 hsa-miR-606_st 0.24109563 1.2 0.181705923 0 hsa-miR-3178_st −0.324916336 1.3 0.076234056 0 hsa-miR-3179_st −0.144469575 1.1 0.252248486 0 hsa-miR-3180-3p_st −0.39804147 1.3 0.022576113 1 hsa-miR-597_st 0.311808196 1.2 0.077619238 0 hsa-miR-148b-star_st 0.325395275 1.3 0.493046729 0 hsa-miR-3182_st 0.049297635 1.0 0.94256345 0 hsa-miR-3183_st −0.381333046 1.3 0.031748846 1 hsa-miR-144-star_st 0.245967497 1.2 0.817863664 0 hsa-miR-3185_st −0.42429146 1.3 0.006872335 1 hsa-miR-4270_st −0.395746034 1.3 0.002246656 1 hsa-miR-3186-5p_st −0.202034379 1.2 0.263945608 0 hsa-miR-3187_st −0.59552154 1.5 0.000752342 1 hsa-miR-3188_st −0.650448924 1.6 0.000148429 1 hsa-miR-3189_st −0.536216522 1.5 0.017541012 1 hsa-miR-548b-3p_st 0.165564469 1.1 0.357856676 0 hsa-miR-99a-star_st 0.378679583 1.3 0.029104819 1 hsa-miR-376a-star_st 0.143523874 1.1 0.754223064 0 hsa-miR-216b_st 0.33464651 1.3 0.079911971 0 hsa-miR-3193_st −0.117865737 1.1 0.339670933 0 hsa-miR-548v_st 0.181677341 1.1 0.383514414 0 hsa-miR-26a-1-star_st −0.113022689 1.1 0.142542744 0 hsa-miR-1291_st −0.188694808 1.1 0.558761121 0 hsa-miR-3197_st −0.416280922 1.3 0.031470741 1 hsa-miR-629_st 0.53059199 1.4 0.047136654 1 hsa-miR-3199_st −0.073753948 1.1 0.752895194 0 hsa-miR-190b_st 0.150853396 1.1 0.467457706 0 hsa-miR-32_st 0.379471614 1.3 0.324251922 0 hsa-miR-3200_st 0.39681502 1.3 0.594993034 0 hsa-miR-3201_st −0.197132532 1.1 0.141976926 0 hsa-miR-3202_st −0.165833823 1.1 0.75062254 0 hsa-miR-320a_st 0.031341695 1.0 0.739224092 0 hsa-miR-4289_st 0.305557709 1.2 0.476379713 0 hsa-miR-655_st 0.275794223 1.2 0.199105615 0 hsa-miR-320b_st 0.263822749 1.2 0.390287903 0 hsa-miR-219-5p_st 0.32310387 1.3 0.135969301 0 hsa-miR-323-3p_st 0.102714784 1.1 0.568869503 0 hsa-miR-323-5p_st −0.677397776 1.6 0.002057983 1 hsa-miR-323b-3p_st −0.063146339 1.0 0.332946797 0 hsa-miR-103-as_st 0.446114831 1.4 0.406509695 0 hsa-miR-424-star_st 0.409370915 1.3 0.01747411 1 hsa-miR-33a-star_st 0.702410697 1.6 0.003440344 1 hsa-miR-325_st −0.29161421 1.2 0.144937243 0 hsa-miR-590-3p_st 0.053234507 1.0 0.996316858 0 hsa-miR-328_st 0.484581153 1.4 0.04436787 1 hsa-miR-329_st 0.468923974 1.4 0.261414375 0 hsa-miR-32-star_st −0.002071102 1.0 0.837603528 0 hsa-miR-330-3p_st 0.108227539 1.1 0.495598243 0 hsa-miR-330-5p_st −0.248644944 1.2 0.132529571 0 hsa-miR-146a-star_st 0.425698974 1.3 0.007237824 1 hsa-miR-331-5p_st 0.304603187 1.2 0.198622198 0 hsa-miR-3167_st −0.15042957 1.1 0.132278021 0 hsa-miR-335-star_st 0.033221219 1.0 0.948001108 0 hsa-miR-337-3p_st −0.206645095 1.2 0.211291805 0 hsa-miR-337-5p_st 0.087872207 1.1 0.936031535 0 hsa-miR-421_st 0.756107095 1.7 0.005915337 1 hsa-miR-338-5p_st 0.385981843 1.3 0.019881365 1 hsa-miR-339-3p_st 0.242986305 1.2 0.364644233 0 hsa-miR-548a-5p_st 0.250044053 1.2 0.075005341 0 hsa-miR-33a_st 0.079184898 1.1 0.893015221 0 hsa-miR-590-5p_st 0.497732874 1.4 0.113867735 0 hsa-miR-33b_st 0.164476591 1.1 0.386739804 0 hsa-miR-616-star_st 0.360624151 1.3 0.188910655 0 hsa-miR-569_st 0.044737942 1.0 0.948954854 0 hsa-miR-340-star_st 0.23734343 1.2 0.822883424 0 hsa-miR-342-3p_st 0.916270247 1.9 0.007606699 1 hsa-miR-135b-star_st −0.240589471 1.2 0.494181719 0 hsa-miR-345_st 0.537798944 1.5 0.128822349 0 hsa-miR-1288_st −0.306269153 1.2 0.010579268 1 hsa-miR-135a_st 0.332346382 1.3 0.167518586 0 hsa-miR-34a-star_st 1.412262908 2.7 4.62432E−06 1 hsa-miR-34b_st 0.075498263 1.1 0.771732268 0 hsa-miR-4288_st 0.541843179 1.5 0.000322195 1 hsa-miR-222-star_st 1.619255569 3.1  6.5231E−08 1 hsa-miR-933_st 0.517830677 1.4 0.000488625 1 hsa-miR-361-3p_st 0.893085031 1.9 0.002838072 1 hsa-miR-224-star_st 0.650757144 1.6 7.18153E−05 1 hsa-miR-362-3p_st 0.611487126 1.5 0.113774191 0 hsa-miR-362-5p_st 0.812726568 1.8 0.035038911 1 hsa-miR-363_st 0.300075295 1.2 0.899375362 0 hsa-miR-363-star_st −0.411600303 1.3 0.096372894 0 hsa-miR-1979_st 0.234834332 1.2 0.15559618 0 hsa-miR-365-star_st −0.65784463 1.6 2.95972E−05 1 hsa-miR-548x_st 0.191663608 1.1 0.473809154 0 hsa-miR-367-star_st 0.228618965 1.2 0.444389 0 hsa-miR-369-3p_st 0.079192264 1.1 0.938584045 0 hsa-miR-369-5p_st 0.38370611 1.3 0.284930739 0 hsa-miR-548l_st −0.357788449 1.3 0.003068723 1 hsa-miR-371-3p_st 0.028118225 1.0 0.896624958 0 hsa-miR-371-5p_st −0.675633424 1.6 0.000284331 1 hsa-miR-372_st −0.209821004 1.2 0.100365975 0 hsa-miR-373_st −0.200926298 1.1 0.150770571 0 hsa-miR-373-star_st −0.703405456 1.6 0.000549114 1 hsa-miR-374a_st 0.926305331 1.9 0.03393499 1 hsa-miR-374a-star_st 0.305877302 1.2 0.180851549 0 hsa-miR-500_st 0.544053308 1.5 0.123353807 0 hsa-miR-320c_st 0.384686554 1.3 0.23156477 0 hsa-miR-875-3p_st −0.100148108 1.1 0.548997441 0 hsa-miR-376a_st 0.243165228 1.2 0.446619806 0 hsa-miR-29b-1-star_st 1.381274558 2.6 1.06486E−08 1 hsa-miR-376b_st 0.196773499 1.1 0.482988609 0 hsa-miR-376c_st 0.476501212 1.4 0.349211393 0 hsa-miR-377_st 0.04502713 1.0 0.817004286 0 hsa-miR-377-star_st 0.10112772 1.1 0.572753614 0 hsa-miR-378_st 0.196431612 1.1 0.614381174 0 hsa-miR-378b_st −0.359615329 1.3 0.001544915 1 hsa-miR-378c_st 0.003465018 1.0 0.774234835 0 hsa-miR-378-star_st 0.213515147 1.2 0.680533548 0 hsa-miR-662_st 0.763588292 1.7 1.07501E−05 1 hsa-miR-379-star_st 0.227503468 1.2 0.299168737 0 hsa-miR-380_st 0.097700397 1.1 0.616418601 0 hsa-miR-380-star_st −0.013558542 1.0 0.603823228 0 hsa-miR-1274b_st 0.845393159 1.8 8.83277E−06 1 hsa-miR-382_st −0.054872541 1.0 0.471142984 0 hsa-miR-383_st −0.241581552 1.2 0.230492847 0 hsa-miR-384_st 0.149079123 1.1 0.551389794 0 hsa-miR-126-star_st 0.089161991 1.1 0.813213299 0 hsa-miR-409-5p_st 0.057478949 1.0 0.726066758 0 hsa-miR-410_st 0.119761141 1.1 0.924713955 0 hsa-miR-411_st 0.035735668 1.0 0.947773657 0 hsa-miR-411-star_st 0.233518908 1.2 0.274393389 0 hsa-miR-412_st −0.230455194 1.2 0.094585458 0 hsa-miR-3143_st −0.049299534 1.0 0.505837404 0 hsa-miR-422a_st −0.002713527 1.0 0.663973065 0 hsa-miR-628-5p_st 0.439025551 1.4 0.151445525 0 hsa-miR-423-5p_st −0.404595069 1.3  4.1287E−05 1 hsa-miR-27b-star_st 1.345333447 2.5 6.12598E−11 1 hsa-miR-499-5p_st 0.592704906 1.5 0.001377201 1 hsa-miR-425_st 1.46433333 2.8 0.002796431 1 hsa-miR-193b_st 0.507490483 1.4 0.040473273 1 hsa-miR-4252_st −0.172298982 1.1 0.148194693 0 hsa-miR-4253_st −0.540168527 1.5 0.002206523 1 hsa-miR-4254_st 0.377577983 1.3 0.011427783 1 hsa-miR-324-3p_st 0.366781202 1.3 0.274311175 0 hsa-miR-4329_st 0.584404594 1.5 2.34854E−05 1 hsa-miR-1251_st 0.712759923 1.6 0.000898935 1 hsa-miR-4258_st −0.265408362 1.2 0.101479443 0 hsa-miR-1274a_st 1.396590701 2.6 9.66639E−06 1 hsa-miR-425-star_st −0.035561492 1.0 0.368955534 0 hsa-miR-4260_st −0.549233748 1.5 0.003101776 1 hsa-miR-4261_st −0.131817236 1.1 0.947174184 0 hsa-miR-4262_st −0.100446121 1.1 0.190462159 0 hsa-miR-4263_st 0.022331211 1.0 0.706219063 0 hsa-miR-4264_st 0.046291164 1.0 0.992089982 0 hsa-miR-1280_st 0.531015773 1.4 0.002892407 1 hsa-miR-132-star_st 1.193843307 2.3 5.16813E−05 1 hsa-miR-4267_st −0.31842273 1.2 0.086827512 0 hsa-miR-4268_st −0.022608683 1.0 0.638667513 0 hsa-miR-133a_st 0.26043092 1.2 0.488072584 0 hsa-miR-888-star_st 0.069768899 1.0 0.878560963 0 hsa-miR-1260b_st 0.56665893 1.5 0.001477379 1 hsa-miR-4272_st 0.047875654 1.0 0.922564818 0 hsa-miR-4273_st 0.008323529 1.0 0.949193841 0 hsa-miR-4274_st 0.031306372 1.0 0.654021907 0 hsa-miR-4275_st 0.274356152 1.2 0.193038743 0 hsa-miR-4276_st 0.149602497 1.1 0.792683539 0 hsa-miR-4277_st −0.028296434 1.0 0.468126529 0 hsa-miR-4278_st −0.33927234 1.3 0.157634019 0 hsa-miR-4279_st −0.051171417 1.0 0.775988362 0 hsa-miR-4280_st −0.144129929 1.1 0.426319175 0 hsa-miR-4281_st −0.245192821 1.2 0.10169252 0 hsa-miR-4282_st 0.0883115 1.1 0.714236975 0 hsa-miR-4283_st −0.523762966 1.4 0.008304566 1 hsa-miR-4284_st 0.289625456 1.2 0.067562954 0 hsa-miR-23b-star_st 0.674734444 1.6 0.00016754 1 hsa-miR-574-3p_st 0.493680235 1.4 0.016968497 1 hsa-miR-4287_st −0.330389027 1.3 0.05809358 0 hsa-miR-320e_st 0.658151384 1.6 0.037311305 1 hsa-miR-339-5p_st 1.068143508 2.1 0.003493607 1 hsa-miR-505_st 0.816928161 1.8 0.013571202 1 hsa-miR-4290_st −0.074745651 1.1 0.917624577 0 hsa-miR-200b-star_st 0.472418518 1.4 0.010314667 1 hsa-miR-4292_st −0.561491115 1.5 0.002877083 1 hsa-miR-4293_st −0.195543258 1.1 0.129949588 0 hsa-miR-1246_st 0.448320609 1.4 0.002204115 1 hsa-miR-4295_st 0.087703996 1.1 0.769149115 0 hsa-miR-4296_st −0.42212698 1.3 0.041649355 1 hsa-miR-4297_st −0.222550583 1.2 0.364173748 0 hsa-miR-4298_st −0.509384082 1.4 0.000238858 1 hsa-miR-218_st 1.531746761 2.9 2.68386E−06 1 hsa-miR-4286_st 0.986581034 2.0  7.793E−05 1 hsa-miR-4301_st 0.246302895 1.2 0.209320166 0 hsa-miR-4302_st −0.39810134 1.3 0.029726087 1 hsa-miR-365_st 0.322524305 1.3 0.155233838 0 hsa-miR-4304_st −0.325010347 1.3 0.131393604 0 hsa-miR-4305_st 0.131987059 1.1 0.629483336 0 hsa-miR-4306_st 0.18368738 1.1 0.906703202 0 hsa-miR-26a_st 0.731517215 1.7 0.000973168 1 hsa-miR-4308_st 0.126508126 1.1 0.726031428 0 hsa-miR-4309_st 0.11828394 1.1 0.301547703 0 hsa-miR-186_st 0.981928548 2.0 0.017912001 1 hsa-miR-4310_st −0.318253176 1.2 0.185655282 0 hsa-miR-4311_st −0.099894225 1.1 0.508741816 0 hsa-miR-4312_st −0.319187789 1.2 0.059733035 0 hsa-miR-4313_st 0.057807986 1.0 0.533807726 0 hsa-miR-4314_st −0.573075857 1.5 0.074819139 0 hsa-miR-4315_st −0.045208689 1.0 0.778907653 0 hsa-miR-149_st 0.991769572 2.0 2.07887E−05 1 hsa-miR-106b-star_st 0.756887645 1.7 0.081496092 0 hsa-miR-4318_st −0.125790696 1.1 0.114713029 0 hsa-miR-4319_st 3.3607E−05 1.0 0.721561227 0 hsa-miR-29b-2-star_st 0.970878605 2.0 0.000691297 1 hsa-miR-432_st −0.424110692 1.3 0.050867914 0 hsa-miR-4320_st 0.141840951 1.1 0.305275801 0 hsa-miR-522_st 0.038498664 1.0 0.94513551 0 hsa-miR-4322_st −0.623367889 1.5 0.000138789 1 hsa-miR-4323_st −0.164242896 1.1 0.102224887 0 hsa-miR-93-star_st 0.7694271 1.7 0.094194312 0 hsa-miR-4325_st 0.227381131 1.2 0.216657261 0 hsa-miR-4326_st 0.008303948 1.0 0.423165271 0 hsa-miR-874_st −0.503966615 1.4 0.000346609 1 hsa-miR-4328_st 0.122228922 1.1 0.641831652 0 hsa-let-7e-star_st 0.838867983 1.8 9.47634E−06 1 hsa-miR-720_st 0.159440883 1.1 0.231843963 0 hsa-miR-433_st −0.297351442 1.2 0.10290867 0 hsa-miR-4330_st −0.098292553 1.1 0.728722347 0 hsa-miR-448_st −0.085705823 1.1 0.426042536 0 hsa-miR-449a_st 0.366580686 1.3 0.00793599 1 hsa-miR-449b_st 0.023835538 1.0 0.984070323 0 hsa-miR-1975_st 0.065733098 1.0 0.64181964 0 hsa-miR-449c_st −0.614519733 1.5 0.023372257 1 hsa-miR-449c-star_st −0.121362017 1.1 0.35285535 0 hsa-miR-1_st 0.576677084 1.5 0.175040016 0 hsa-miR-450b-3p_st 0.062981579 1.0 0.940591891 0 hsa-miR-450b-5p_st 0.131221455 1.1 0.738380499 0 hsa-miR-451_st 0.087909523 1.1 0.902828672 0 hsa-miR-452_st 0.14628175 1.1 0.276965995 0 hsa-miR-452-star_st −0.013845816 1.0 0.524568582 0 hsa-miR-548b-5p_st −0.223673286 1.2 0.02301896 1 hsa-miR-454-star_st 0.153592273 1.1 0.709524442 0 hsa-miR-455-3p_st 0.429029588 1.3 0.03265621 1 hsa-miR-455-5p_st 0.334081936 1.3 0.114091363 0 hsa-miR-466_st 0.237582262 1.2 0.274043516 0 hsa-miR-483-3p_st −0.003579204 1.0 0.673764763 0 hsa-miR-17_st 1.280302358 2.4 0.002663743 1 hsa-miR-320d_st 0.609805751 1.5 0.081568607 0 hsa-miR-485-3p_st 0.051314079 1.0 0.714077809 0 hsa-miR-485-5p_st −0.374240628 1.3 0.075836232 0 hsa-miR-486-3p_st −0.479726394 1.4 0.009009035 1 hsa-miR-486-5p_st −0.516559938 1.4 0.073247071 0 hsa-miR-644_st −0.021364394 1.0 0.607886124 0 hsa-miR-3152_st −0.645703485 1.6 0.013781726 1 hsa-miR-488_st 0.17051326 1.1 0.309623859 0 hsa-miR-488-star_st 0.020035891 1.0 0.854491308 0 hsa-miR-450a_st 1.177111428 2.3 1.62434E−05 1 hsa-miR-20a_st 1.52088829 2.9 0.00108399 1 hsa-miR-484_st 0.779514219 1.7 0.096639651 0 hsa-miR-491-3p_st 0.207398076 1.2 0.368163528 0 hsa-miR-491-5p_st −0.038602201 1.0 0.967909058 0 hsa-miR-197_st 0.66899893 1.6 0.041442563 1 hsa-miR-493_st 0.060363307 1.0 0.517703068 0 hsa-miR-493-star_st 0.393211268 1.3 0.309068907 0 hsa-miR-494_st −0.517544894 1.4 0.009758189 1 hsa-miR-495_st 0.589319919 1.5 0.25588984 0 hsa-miR-496_st 0.145656451 1.1 0.79618088 0 hsa-miR-497_st 0.251078501 1.2 0.236697173 0 hsa-miR-497-star_st 0.098309609 1.1 0.769168398 0 hsa-miR-498_st −0.632854392 1.6 0.000321265 1 hsa-miR-499-3p_st 0.187477685 1.1 0.328365055 0 hsa-miR-24-1-star_st 1.073684055 2.1 0.000145774 1 hsa-miR-340_st 1.277302225 2.4 0.000254287 1 hsa-miR-500b_st 0.294745175 1.2 0.606052116 0 hsa-miR-500-star_st −0.176098719 1.1 0.15677611 0 hsa-miR-501-3p_st −0.295874074 1.2 0.011517777 1 hsa-miR-501-5p_st 0.028766386 1.0 0.564678845 0 hsa-miR-502-3p_st −0.181888519 1.1 0.245192366 0 hsa-miR-502-5p_st 0.018519743 1.0 0.526147604 0 hsa-miR-503_st −0.395058426 1.3 0.012938435 1 hsa-miR-192_st 1.408219456 2.7 0.001683851 1 hsa-let-7g_st 0.951098893 1.9 0.000556005 1 hsa-miR-505-star_st −0.117754301 1.1 0.412878727 0 hsa-miR-506_st 0.08018806 1.1 0.650324727 0 hsa-miR-507_st 0.107076115 1.1 0.784908678 0 hsa-miR-508-3p_st 0.171625966 1.1 0.510074082 0 hsa-miR-508-5p_st −0.409707488 1.3 0.08539915 0 hsa-miR-509-3-5p_st −0.224948007 1.2 0.435423506 0 hsa-miR-509-3p_st −0.198270923 1.1 0.237548418 0 hsa-miR-106a_st 1.387442345 2.6 0.001376282 1 hsa-miR-106b_st 1.503196879 2.8 0.000594296 1 hsa-miR-511_st −0.05786449 1.0 0.470208528 0 hsa-miR-512-3p_st −0.300259224 1.2 0.025341252 1 hsa-miR-512-5p_st −0.189876727 1.1 0.327500962 0 hsa-miR-513a-3p_st 0.147832753 1.1 0.90217688 0 hsa-miR-23a_st 0.884694686 1.8 0.000352968 1 hsa-miR-25_st 1.185057753 2.3 0.002512048 1 hsa-miR-598_st 1.226426823 2.3 0.000111603 1 hsa-miR-1260_st 1.048914152 2.1 1.05371E−05 1 hsa-miR-514b-3p_st 0.031479132 1.0 0.807900103 0 hsa-miR-514b-5p_st −0.433113987 1.4 0.084324372 0 hsa-miR-515-3p_st −0.124604022 1.1 0.250116715 0 hsa-miR-515-5p_st −0.064987586 1.0 0.448814814 0 hsa-miR-516a-3p_st 0.067879583 1.0 0.543462019 0 hsa-miR-27a_st 1.343744849 2.5 1.84384E−05 1 hsa-miR-100_st 0.702747422 1.6 0.003396779 1 hsa-miR-101_st 1.471342647 2.8 0.002391542 1 hsa-miR-517a_st 0.194954754 1.1 0.425874486 0 hsa-miR-517b_st 0.156034295 1.1 0.372704275 0 hsa-miR-517c_st 0.047605038 1.0 0.896054297 0 hsa-miR-517-star_st −0.107791491 1.1 0.554795002 0 hsa-miR-518a-3p_st −0.094504876 1.1 0.256203316 0 hsa-miR-518a-5p_st −0.413729016 1.3 0.187456262 0 hsa-miR-518b_st 0.088807039 1.1 0.528113313 0 hsa-miR-518c_st 0.099106728 1.1 0.656628824 0 hsa-miR-301a_st 1.229986909 2.3 0.007070412 1 hsa-miR-518d-3p_st −0.070042193 1.0 0.448313542 0 hsa-miR-518d-5p_st −0.112868354 1.1 0.953533136 0 hsa-miR-518e_st 0.292065323 1.2 0.082091477 0 hsa-let-7f_st 0.782597495 1.7 0.000877066 1 hsa-miR-518f_st 0.10510646 1.1 0.815781034 0 hsa-miR-1826_st −0.039286991 1.0 0.726221744 0 hsa-miR-519a_st −0.045402557 1.0 0.461383253 0 hsa-miR-519a-star_st −0.382392357 1.3 0.099584817 0 hsa-miR-519b-3p_st 0.092177111 1.1 0.798480341 0 hsa-miR-1283_st −0.152770096 1.1 0.101080096 0 hsa-miR-519c-3p_st 0.012292479 1.0 0.655642874 0 hsa-miR-519c-5p_st −0.289621284 1.2 0.325886895 0 hsa-miR-519d_st 0.127516999 1.1 0.48000076 0 hsa-miR-519e_st 0.427023433 1.3 0.002801606 1 hsa-miR-519e-star_st −0.392432506 1.3 0.197229694 0 hsa-miR-520a-3p_st 0.073997868 1.1 0.760236215 0 hsa-miR-1908_st −0.048787304 1.0 0.71747425 0 hsa-miR-520b_st 0.096423039 1.1 0.977921461 0 hsa-miR-520c-3p_st 0.104001753 1.1 0.92273025 0 hsa-miR-520c-5p_st −0.04378828 1.0 0.741518073 0 hsa-miR-181a-star_st 1.231483023 2.3 2.86829E−05 1 hsa-miR-21_st 2.403298997 5.3 2.52274E−07 1 hsa-miR-520e_st −0.020382845 1.0 0.742603812 0 hsa-miR-520f_st 0.271286942 1.2 0.103461226 0 hsa-miR-520g_st 0.069632427 1.0 0.962905246 0 hsa-miR-520h_st 0.068680109 1.0 0.636074311 0 hsa-miR-521_st 0.330682833 1.3 0.035773465 1 hsa-miR-302a-star_st −0.136094511 1.1 0.104813388 0 hsa-miR-886-3p_st 0.905098806 1.9 0.002050876 1 hsa-miR-523_st 0.027147295 1.0 0.844981122 0 hsa-miR-29a_st 1.375508718 2.6 2.88816E−06 1 hsa-miR-524-3p_st −0.198145779 1.1 0.086716632 0 hsa-miR-142-3p_st −0.011017493 1.0 0.388997211 0 hsa-miR-525-3p_st −0.211180947 1.2 0.068652678 0 hsa-miR-525-5p_st −0.098964363 1.1 0.737175826 0 hsa-miR-762_st −0.081948997 1.1 0.556859762 0 hsa-miR-423-3p_st 0.970758984 2.0 0.00014707 1 hsa-miR-449b-star_st −0.34371066 1.3 0.173898667 0 hsa-miR-527_st −0.412065956 1.3 0.125421726 0 hsa-miR-532-3p_st 0.436379865 1.4 0.276500673 0 hsa-miR-532-5p_st 0.560594636 1.5 0.115791549 0 hsa-miR-539_st 0.192944212 1.1 0.393435942 0 hsa-let-7a_st 0.727952266 1.7 0.000940984 1 hsa-miR-541-star_st −0.228586147 1.2 0.143001924 0 hsa-miR-542-3p_st 0.272885547 1.2 0.317437786 0 hsa-miR-542-5p_st 0.687207164 1.6 9.68402E−06 1 hsa-miR-543_st 0.042876484 1.0 0.64976712 0 hsa-miR-544_st 0.041712614 1.0 0.86364095 0 hsa-miR-544b_st −0.138680853 1.1 0.28945059 0 hsa-miR-545_st 0.014502165 1.0 0.831334779 0 hsa-miR-545-star_st 0.272930768 1.2 0.254388135 0 hsa-miR-548a-3p_st 0.081691307 1.1 0.996125063 0 hsa-miR-2861_st −0.074130242 1.1 0.594353575 0 hsa-miR-31_st 2.756212833 6.8 1.62816E−05 1 hsa-miR-367_st −0.025354841 1.0 0.728359058 0 hsa-miR-548c-3p_st 0.304646502 1.2 0.240803422 0 hsa-miR-548c-5p_st 0.205390424 1.2 0.247886209 0 hsa-miR-548d-3p_st 0.114750589 1.1 0.745723133 0 hsa-miR-548d-5p_st 0.103099793 1.1 0.602511689 0 hsa-miR-548e_st 0.031213042 1.0 0.835974584 0 hsa-miR-548f_st 0.048760585 1.0 0.927328557 0 hsa-miR-548g_st 0.142662826 1.1 0.663781925 0 hsa-miR-548h_st 0.363589905 1.3 0.02502833 1 hsa-miR-548i_st 0.040552783 1.0 0.848917438 0 hsa-miR-548j_st −0.113264276 1.1 0.172409604 0 hsa-miR-548k_st 0.058910016 1.0 0.585610341 0 hsa-miR-526b-star_st −0.022783961 1.0 0.606339957 0 hsa-miR-548m_st −0.069590121 1.0 0.587856834 0 hsa-miR-548n_st 0.194176229 1.1 0.429688871 0 hsa-miR-548o_st 0.105646683 1.1 0.948040467 0 hsa-miR-548p_st 0.066531205 1.0 0.843745461 0 hsa-miR-548q_st −0.764227588 1.7 0.000146092 1 hsa-miR-548s_st −0.02215727 1.0 0.582525502 0 hsa-miR-548t_st −0.045938372 1.0 0.397777564 0 hsa-miR-548u_st 0.335583711 1.3 0.202550776 0 hsa-miR-638_st −0.010692313 1.0 0.870008646 0 hsa-miR-548w_st 0.062890236 1.0 0.754125712 0 hsa-miR-3119_st −0.120941951 1.1 0.202890168 0 hsa-miR-549_st −0.019785312 1.0 0.948777667 0 hsa-miR-205_st 0.919503386 1.9 0.126603166 0 hsa-miR-550-star_st 0.423733934 1.3 0.700524508 0 hsa-miR-551a_st −0.026394791 1.0 0.632299916 0 hsa-miR-93_st 1.316454658 2.5 0.001256201 1 hsa-miR-551b-star_st 0.022968016 1.0 0.776835489 0 hsa-let-7d-star_st 0.725060868 1.7 0.028345162 1 hsa-miR-553_st 0.228656256 1.2 0.107976485 0 hsa-miR-554_st −0.079907143 1.1 0.261310822 0 hsa-miR-555_st −0.183975779 1.1 0.043510403 1 hsa-miR-556-3p_st −0.165194459 1.1 0.12275829 0 hsa-miR-556-5p_st 0.134116363 1.1 0.787222646 0 hsa-miR-557_st −0.554496973 1.5 0.003307682 1 hsa-miR-558_st 0.201336596 1.1 0.212711162 0 hsa-miR-559_st 0.071711274 1.1 0.911630553 0 hsa-miR-561_st 0.047188353 1.0 0.965398954 0 hsa-miR-562_st 0.054915353 1.0 0.816102928 0 hsa-miR-563_st 0.009966974 1.0 0.810157422 0 hsa-miR-361-5p_st 1.108905457 2.2 5.96082E−06 1 hsa-miR-566_st −0.290040905 1.2 0.060673372 0 hsa-miR-567_st −0.206447885 1.2 0.138576754 0 hsa-miR-568_st 0.000723722 1.0 0.785135731 0 hsa-miR-29c_st 1.328300194 2.5 3.39711E−05 1 hsa-miR-570_st 0.214552405 1.2 0.550796157 0 hsa-miR-571_st −0.061229473 1.0 0.567493691 0 hsa-miR-572_st −0.547334433 1.5 0.003043097 1 hsa-miR-573_st 0.038677237 1.0 0.928813658 0 hsa-miR-132_st 1.632328536 3.1 1.12141E−06 1 hsa-miR-574-5p_st −0.047786855 1.0 0.605645966 0 hsa-let-7d_st 0.815898536 1.8 0.000824037 1 hsa-miR-576-3p_st −0.143684496 1.1 0.175134581 0 hsa-miR-576-5p_st −0.055506895 1.0 0.525334138 0 hsa-miR-577_st −0.03556996 1.0 0.494231971 0 hsa-miR-578_st 0.469196689 1.4 0.000245009 1 hsa-miR-579_st 0.126170739 1.1 0.757062969 0 hsa-miR-580_st −0.026764192 1.0 0.58110593 0 hsa-miR-191_st 1.170520227 2.3 0.000375032 1 hsa-miR-582-3p_st −0.062689881 1.0 0.615008094 0 hsa-miR-582-5p_st −0.090612263 1.1 0.221774204 0 hsa-miR-1915_st −0.022341375 1.0 0.790524125 0 hsa-let-7c_st 0.803808067 1.7 0.001218364 1 hsa-miR-585_st 0.097070232 1.1 0.451375948 0 hsa-miR-586_st 0.03814739 1.0 0.694978787 0 hsa-miR-324-5p_st 1.213321942 2.3 0.000822739 1 hsa-miR-588_st −0.096705702 1.1 0.434699598 0 hsa-miR-589_st 0.205412041 1.2 0.836859756 0 hsa-miR-589-star_st −0.15318523 1.1 0.073778148 0 hsa-miR-188-5p_st −0.686412511 1.6 2.00965E−05 1 hsa-miR-103_st 1.179605862 2.3 0.000220273 1 hsa-miR-591_st −0.11283514 1.1 0.318421891 0 hsa-miR-592_st 0.287219487 1.2 0.117340504 0 hsa-miR-593_st −0.297131666 1.2 0.090455411 0 hsa-miR-23b_st 1.005976608 2.0 2.55494E−05 1 hsa-miR-595_st −0.302923138 1.2 0.066277532 0 hsa-miR-99a_st 0.881711459 1.8 0.001028468 1 hsa-miR-15b_st 1.119501934 2.2 0.006089066 1 hsa-miR-135b_st 1.134920075 2.2 0.00053113 1 hsa-miR-599_st 0.116299041 1.1 0.721569135 0 hsa-miR-600_st −0.054526051 1.0 0.589350164 0 hsa-miR-107_st 1.227964029 2.3 0.000270999 1 hsa-miR-602_st −0.499235292 1.4 0.003014943 1 hsa-miR-603_st 0.134129003 1.1 0.595338944 0 hsa-miR-3065-5p_st 1.343878918 2.5 1.41378E−05 1 hsa-miR-605_st −0.024938167 1.0 0.963725922 0 hsa-miR-24_st 1.299778717 2.5 1.84637E−06 1 hsa-miR-607_st 0.214153071 1.2 0.342950759 0 hsa-miR-608_st −0.483908277 1.4 0.008742334 1 hsa-miR-609_st 0.320165562 1.2 0.060331202 0 hsa-miR-3196_st 0.005111657 1.0 0.890518504 0 hsa-miR-26b_st 1.307409876 2.5 0.000523609 1 hsa-miR-28-5p_st 1.180096914 2.3 0.00093076 1 hsa-miR-613_st −0.056855887 1.0 0.267636275 0 hsa-miR-338-3p_st 1.301544434 2.5 0.000633288 1 hsa-miR-615-3p_st −0.258953941 1.2 0.474989926 0 hsa-miR-454_st 1.648358843 3.1 0.003708464 1 hsa-miR-616_st −0.05808354 1.0 0.892545983 0 hsa-miR-151-5p_st 1.200716494 2.3 0.000138505 1 hsa-miR-617_st −0.447012056 1.4 0.117541577 0 hsa-miR-128_st 1.316192726 2.5 0.000766319 1 hsa-miR-619_st −0.096210988 1.1 0.16600817 0 hsa-miR-620_st −0.173763378 1.1 0.118756965 0 hsa-miR-621_st 0.245006559 1.2 0.095601607 0 hsa-let-7b_st 0.901603763 1.9 0.002372164 1 hsa-miR-623_st −0.563171167 1.5 0.005458933 1 hsa-miR-624_st 0.20648621 1.2 0.200800858 0 hsa-miR-624-star_st 0.092852362 1.1 0.497235964 0 hsa-miR-183_st 1.153214093 2.2 0.021280779 1 hsa-miR-30b_st 1.323660775 2.5 0.000115837 1 hsa-miR-626_st 0.083991901 1.1 0.773036467 0 hsa-miR-627_st 0.115102085 1.1 0.98200278 0 hsa-miR-628-3p_st −0.597876998 1.5 0.018097305 1 hsa-miR-31-star_st 2.95516693 7.8 8.40808E−06 1 hsa-miR-218-1-star_st 0.019223529 1.0 0.854012682 0 hsa-miR-629-star_st 0.42813735 1.3 0.039800462 1 hsa-miR-630_st −0.793740227 1.7 0.011695073 1 hsa-miR-631_st −0.697127546 1.6 0.003865987 1 hsa-miR-632_st 0.10249186 1.1 0.662502801 0 hsa-miR-633_st 0.111376809 1.1 0.684042887 0 hsa-miR-634_st 0.054779708 1.0 0.701961312 0 hsa-miR-635_st −0.123472743 1.1 0.541749232 0 hsa-miR-203_st 1.380152897 2.6 0.001372286 1 hsa-miR-331-3p_st 0.843945301 1.8 0.012373089 1 hsa-miR-125b_st 0.930522281 1.9 3.23532E−05 1 hsa-let-7i_st 1.304026353 2.5 4.73346E−05 1 hsa-miR-640_st −0.147969894 1.1 0.443934792 0 hsa-miR-641_st 0.102753081 1.1 0.915582667 0 hsa-miR-642_st 0.126270613 1.1 0.519612819 0 hsa-miR-29b_st 1.763846347 3.4 1.40667E−06 1 hsa-miR-122_st −0.479354476 1.4 0.010846614 1 hsa-miR-645_st −0.121847591 1.1 0.14825713 0 hsa-miR-646_st 0.124012357 1.1 0.319852173 0 hsa-miR-647_st −0.062675481 1.0 0.778020524 0 hsa-miR-648_st −0.629157048 1.5 0.000416072 1 hsa-miR-649_st 0.103239826 1.1 0.565659407 0 hsa-miR-182_st 1.483418105 2.8 0.003984442 1 hsa-miR-651_st −0.028427575 1.0 0.497954662 0 hsa-miR-652_st −0.101245497 1.1 0.380732905 0 hsa-miR-653_st 0.178894233 1.1 0.660059889 0 hsa-miR-654-3p_st 0.286686636 1.2 0.607544215 0 hsa-miR-374b_st 1.643381641 3.1 0.000157002 1 hsa-miR-130a_st 1.414936386 2.7 4.65391E−05 1 hsa-miR-656_st −0.041729916 1.0 0.467218433 0 hsa-miR-657_st −0.018447866 1.0 0.781685938 0 hsa-miR-658_st −0.578638762 1.5 0.004086297 1 hsa-miR-99b_st 1.230967815 2.3 2.67522E−07 1 hsa-miR-660_st 1.065262832 2.1 0.015165758 1 hsa-miR-661_st −0.546815735 1.5 0.006490085 1 hsa-miR-30e-star_st 1.052544393 2.1 0.002485259 1 hsa-miR-663_st −0.214772664 1.2 0.160677462 0 hsa-miR-663b_st −0.585193882 1.5 0.012885321 1 hsa-miR-664_st 0.428380051 1.3 0.145493286 0 hsa-miR-664-star_st −0.342841978 1.3 0.305667842 0 hsa-miR-30d_st 1.119681573 2.2 0.000617852 1 hsa-miR-668_st −0.351093124 1.3 0.181456934 0 hsa-miR-670_st −0.238296944 1.2 0.139767008 0 hsa-miR-671-3p_st 0.183507426 1.1 0.114141268 0 hsa-miR-671-5p_st −0.636090027 1.6 2.96268E−05 1 hsa-miR-30a-star_st 1.096210685 2.1 0.000119159 1 hsa-miR-675-star_st −0.192759172 1.1 0.306860739 0 hsa-miR-148b_st 1.030726446 2.0 0.026559243 1 hsa-miR-708_st 0.18954795 1.1 0.385007072 0 hsa-miR-708-star_st 0.002207619 1.0 0.891128538 0 hsa-miR-221-star_st 2.996227 8.0 3.75772E−09 1 hsa-let-7e_st 1.158251204 2.2 6.93945E−05 1 hsa-miR-7-1-star_st 1.089007502 2.1 0.00228216 1 hsa-miR-27b_st 1.527125861 2.9 6.73838E−06 1 hsa-miR-34a_st 1.920605124 3.8 9.12061E−08 1 hsa-miR-744_st −0.49943743 1.4 0.001120325 1 hsa-miR-744-star_st 0.319311407 1.2 0.092304286 0 hsa-miR-92b_st 1.241521176 2.4 0.00717976 1 hsa-miR-759_st 0.22332995 1.2 0.266934081 0 hsa-miR-760_st −0.561549654 1.5 0.002974681 1 hsa-miR-92a_st 1.466980282 2.8 0.000179428 1 hsa-miR-335_st 1.470918517 2.8 0.000224463 1 hsa-miR-96_st 1.583315263 3.0 0.005022445 1 hsa-miR-95_st 1.223567046 2.3 0.000158676 1 hsa-miR-766_st −0.278158091 1.2 0.056005892 0 hsa-miR-767-3p_st 0.033397634 1.0 0.989784253 0 hsa-miR-767-5p_st −0.042732302 1.0 0.531562479 0 hsa-miR-98_st 1.235453156 2.4 0.001678843 1 hsa-miR-769-5p_st 0.404750144 1.3 0.008723972 1 hsa-miR-770-5p_st −0.107249208 1.1 0.821855114 0 hsa-miR-802_st −0.000886966 1.0 0.70437267 0 hsa-miR-34b-star_st 2.005268347 4.0 3.63387E−09 1 hsa-miR-581_st −0.015680568 1.0 0.737019566 0 hsa-miR-181d_st 1.479502434 2.8 1.37945E−08 1 hsa-miR-875-5p_st 0.029255834 1.0 0.638005997 0 hsa-miR-876-3p_st −0.146072123 1.1 0.179879274 0 hsa-miR-876-5p_st −0.04955472 1.0 0.500219566 0 hsa-miR-151-3p_st 1.659396316 3.2 8.85256E−06 1 hsa-miR-877-star_st −0.314539104 1.2 0.15218137 0 hsa-miR-885-3p_st −0.569096773 1.5 0.003529943 1 hsa-miR-200c_st 1.102081595 2.1  1.6401E−05 1 hsa-miR-429_st 2.326589242 5.0 6.66032E−07 1 hsa-miR-886-5p_st 0.020342006 1.0 0.58069058 0 hsa-miR-224_st 1.819791189 3.5  8.6003E−09 1 hsa-miR-888_st 0.152772525 1.1 0.648238043 0 hsa-miR-4321_st −0.771553945 1.7 0.000508592 1 hsa-miR-889_st −0.163642042 1.1 0.139539478 0 hsa-miR-181b_st 1.661310236 3.2 3.29519E−09 1 hsa-miR-891a_st −0.001905825 1.0 0.675958956 0 hsa-miR-891b_st 0.122778528 1.1 0.84602129 0 hsa-miR-892a_st −0.116949666 1.1 0.423227968 0 hsa-miR-892b_st 0.166561641 1.1 0.177432545 0 hsa-miR-9_st −0.054746755 1.0 0.422141884 0 hsa-miR-222_st 2.983301769 7.9 1.24496E−09 1 hsa-miR-141_st 1.72323742 3.3 8.17029E−07 1 hsa-miR-221_st 3.002048527 8.0 1.37416E−09 1 hsa-miR-924_st 0.211703889 1.2 0.111204346 0 hsa-miR-181a_st 1.719136859 3.3 9.38048E−07 1 hsa-miR-181c_st 1.769387685 3.4 1.74068E−05 1 hsa-miR-4324_st 1.469023191 2.8 2.62923E−06 1 hsa-miR-125a-5p_st 1.345227037 2.5 2.24453E−06 1 hsa-miR-92b-star_st −0.442572641 1.4 0.004154007 1 hsa-miR-3195_st −0.583939454 1.5 0.002089016 1 hsa-miR-3137_st −0.797016102 1.7 0.000110528 1 hsa-miR-934_st −0.01308772 1.0 0.949481661 0 hsa-miR-935_st 0.024765003 1.0 0.940017372 0 hsa-miR-551b_st 2.825353785 7.1 6.46443E−08 1 hsa-miR-937_st −0.14642889 1.1 0.573077793 0 hsa-miR-938_st −0.199216575 1.1 0.172445635 0 hsa-miR-939_st −0.580530727 1.5 0.000753121 1 hsa-miR-7-2-star_st −0.899816343 1.9 0.036822994 1 hsa-miR-146b-5p_st 4.916324482 30.2 3.73776E−13 1 hsa-miR-941_st −0.079960899 1.1 0.224876105 0 hsa-miR-942_st 0.16103157 1.1 0.939611539 0 hsa-miR-200a_st 2.070836736 4.2 5.32624E−05 1 hsa-miR-944_st 0.28470109 1.2 0.168615289 0 hsa-miR-7_st −1.527533332 2.9 0.024812208 1 hsa-miR-375_st 3.296427574 9.8 2.11039E−10 1 hsa-miR-96-star_st −0.03863582 1.0 0.708015916 0 hsa-miR-424_st 2.803832229 7.0 2.81321E−07 1 hsa-miR-181a-2-star_st 2.887223763 7.4 1.80909E−11 1 hsa-miR-200b_st 2.038934882 4.1 1.02714E−05 1 hsa-miR-146b-3p_st 3.798493183 13.9 9.04344E−10 1 hsa-miR-99b-star_st 0.225796912 1.2 0.038445447 1 hsa-miR-9-star_st −0.059772051 1.0 0.705017587 0 Log2 Diff Fold change T-test (FTC vs (FTC vs (FTC vs Sample Name Benign) Benign) Benign) p < 0.05 hsa-miR-150_st −0.705125203 1.6 0.376736 0 hsa-let-7a-2-star_st 0.444703567 1.4 0.014871 1 hsa-let-7a-star_st −0.088495885 1.1 0.542407 0 hsa-miR-513b_st −0.777765295 1.7 0.314133 0 hsa-let-7b-star_st 0.28622064 1.2 0.510261 0 hsa-miR-593-star_st −0.415621434 1.3 0.485997 0 hsa-let-7c-star_st 0.095923767 1.1 0.71416 0 hsa-miR-516a-5p_st −0.436403863 1.4 0.198673 0 hsa-miR-142-5p_st 0.30182632 1.2 0.658574 0 hsa-miR-650_st 0.04478799 1.0 0.803883 0 hsa-miR-513c_st −0.79272027 1.7 0.13602 0 hsa-miR-761_st 0.272311973 1.2 0.396859 0 hsa-let-7f-1-star_st −0.046513066 1.0 0.798852 0 hsa-miR-513a-5p_st −0.258693788 1.2 0.62051 0 hsa-miR-654-5p_st −0.57149263 1.5 0.086647 0 hsa-let-7g-star_st 0.051740906 1.0 0.72708 0 hsa-miR-3163_st −0.380261859 1.3 0.223572 0 hsa-let-7i-star_st 0.507658113 1.4 0.197572 0 hsa-miR-3165_st −0.648782648 1.6 0.237405 0 hsa-miR-3194_st −0.348397348 1.3 0.27491 0 hsa-miR-100-star_st −0.173286704 1.1 0.471298 0 hsa-miR-4251_st −0.377615035 1.3 0.284328 0 hsa-miR-101-star_st 0.249556218 1.2 0.112121 0 hsa-miR-922_st −0.295733273 1.2 0.376891 0 hsa-miR-103-2-star_st 0.526503588 1.4 0.030399 1 hsa-miR-155_st 0.337820839 1.3 0.548863 0 hsa-miR-105_st −0.391655476 1.3 0.01529 1 hsa-miR-127-5p_st −0.210908557 1.2 0.613088 0 hsa-miR-1286_st −0.083760738 1.1 0.817773 0 hsa-miR-106a-star_st −0.037976884 1.0 0.841387 0 hsa-miR-890_st 0.40629793 1.3 0.373653 0 hsa-miR-3126-5p_st −0.536833165 1.5 0.230247 0 hsa-miR-489_st −0.227689784 1.2 0.631372 0 hsa-miR-10a_st 0.504540486 1.4 0.403827 0 hsa-miR-10a-star_st −0.391923756 1.3 0.069901 0 hsa-miR-10b_st 0.95615843 1.9 0.097359 0 hsa-miR-10b-star_st 0.065608654 1.0 0.808163 0 hsa-miR-1178_st −0.191014901 1.1 0.320212 0 hsa-miR-1179_st 0.112417074 1.1 0.526058 0 hsa-miR-1180_st −0.320031753 1.2 0.045333 1 hsa-miR-1181_st −0.064303295 1.0 0.805207 0 hsa-miR-3138_st −0.514667783 1.4 0.256269 0 hsa-miR-220c_st −0.158010245 1.1 0.591023 0 hsa-miR-510_st −0.506521703 1.4 0.240887 0 hsa-miR-1185_st −0.116364427 1.1 0.492826 0 hsa-miR-1193_st −0.311693551 1.2 0.020153 1 hsa-miR-1197_st −0.034176522 1.0 0.748052 0 hsa-miR-1200_st −0.168222557 1.1 0.25252 0 hsa-miR-1201_st 1.346322281 2.5 0.000722 1 hsa-miR-1202_st −0.333126988 1.3 0.11136 0 hsa-miR-30c-1-star_st −0.304027673 1.2 0.449863 0 hsa-miR-1204_st −0.528670243 1.4 0.03777 1 hsa-miR-1205_st −0.150470946 1.1 0.365049 0 hsa-miR-1206_st 0.011492385 1.0 0.931796 0 hsa-miR-1207-3p_st −0.249260077 1.2 0.228909 0 hsa-miR-1207-5p_st −0.139350179 1.1 0.167506 0 hsa-miR-1208_st −0.266966819 1.2 0.174928 0 hsa-miR-622_st −0.184818836 1.1 0.517665 0 hsa-miR-1224-3p_st 0.375517913 1.3 0.045058 1 hsa-miR-2116_st −0.507855103 1.4 0.086096 0 hsa-miR-1225-3p_st −0.2387609 1.2 0.160723 0 hsa-miR-1225-5p_st −0.253987797 1.2 0.030509 1 hsa-miR-1226_st −0.19661027 1.1 0.483823 0 hsa-miR-30b-star_st −0.499633441 1.4 0.1344 0 hsa-miR-1227_st −0.243625314 1.2 0.231206 0 hsa-miR-1295_st −0.436149087 1.4 0.158667 0 hsa-miR-1228-star_st −0.165010503 1.1 0.258944 0 hsa-miR-20b_st 1.372613841 2.6 0.000586 1 hsa-miR-122-star_st −0.092535904 1.1 0.564342 0 hsa-miR-1231_st −0.235406452 1.2 0.109654 0 hsa-miR-1233_st −0.298218185 1.2 0.177965 0 hsa-miR-524-5p_st 0.20482492 1.2 0.331235 0 hsa-miR-1236_st 0.021262206 1.0 0.90298 0 hsa-miR-873_st −0.257309376 1.2 0.464234 0 hsa-miR-1238_st −0.302667989 1.2 0.073741 0 hsa-miR-124_st −0.128693872 1.1 0.653969 0 hsa-miR-1243_st −0.074140994 1.1 0.624874 0 hsa-miR-1244_st 0.241688021 1.2 0.548686 0 hsa-miR-1245_st −0.317269112 1.2 0.035948 1 hsa-miR-3122_st −0.474409619 1.4 0.002429 1 hsa-miR-134_st −0.334717066 1.3 0.169914 0 hsa-miR-1248_st 0.524117052 1.4 0.372505 0 hsa-miR-146a_st 0.000814103 1.0 0.998876 0 hsa-miR-124-star_st −0.273369935 1.2 0.073895 0 hsa-miR-1250_st −0.380906207 1.3 0.064371 0 hsa-miR-764_st −0.292379222 1.2 0.354669 0 hsa-miR-1252_st −0.001167698 1.0 0.994297 0 hsa-miR-223_st 0.509957872 1.4 0.465572 0 hsa-miR-34c-3p_st −0.338884405 1.3 0.305562 0 hsa-miR-1255a_st 0.356106778 1.3 0.269823 0 hsa-miR-1255b_st 0.183244498 1.1 0.690477 0 hsa-miR-1256_st −0.083690389 1.1 0.623034 0 hsa-miR-1257_st 0.010421012 1.0 0.959291 0 hsa-miR-199b-5p_st −0.702876123 1.6 0.456912 0 hsa-miR-1259_st −0.0867272 1.1 0.635978 0 hsa-miR-492_st −0.328908498 1.3 0.094757 0 hsa-miR-3132_st −0.020588389 1.0 0.933656 0 hsa-miR-516b_st −0.305671919 1.2 0.439099 0 hsa-miR-4294_st −0.39687903 1.3 0.307969 0 hsa-miR-125b-2-star_st 0.252725504 1.2 0.530309 0 hsa-miR-126_st 0.58986271 1.5 0.022983 1 hsa-miR-198_st −0.227017752 1.2 0.45234 0 hsa-miR-3191_st −0.110464634 1.1 0.750375 0 hsa-miR-1261_st −0.402076009 1.3 0.332579 0 hsa-miR-1262_st −0.173430033 1.1 0.423837 0 hsa-miR-1263_st 0.034996778 1.0 0.858567 0 hsa-miR-1264_st −0.152946217 1.1 0.40921 0 hsa-miR-1265_st 0.227693074 1.2 0.234864 0 hsa-miR-2114-star_st −0.232898825 1.2 0.598992 0 hsa-miR-1267_st −0.283716499 1.2 0.028521 1 hsa-miR-1268_st −0.265494198 1.2 0.02751 1 hsa-miR-1269_st −0.067539498 1.0 0.75183 0 hsa-miR-509-5p_st −0.452332726 1.4 0.152492 0 hsa-miR-1270_st −0.159396552 1.1 0.500581 0 hsa-miR-1271_st 0.274148026 1.2 0.277666 0 hsa-miR-4303_st −0.372052404 1.3 0.226101 0 hsa-miR-1273_st −0.127787814 1.1 0.683312 0 hsa-miR-583_st 0.362006726 1.3 0.229503 0 hsa-miR-1273d_st 0.004524162 1.0 0.981568 0 hsa-miR-127-3p_st 0.371937468 1.3 0.564117 0 hsa-miR-522-star_st −0.204907492 1.2 0.273233 0 hsa-miR-214-star_st −0.15408747 1.1 0.768303 0 hsa-miR-184_st −0.097760115 1.1 0.773863 0 hsa-miR-614_st −0.158201907 1.1 0.691126 0 hsa-miR-526b_st 0.073159625 1.1 0.715194 0 hsa-miR-1277_st −0.015773675 1.0 0.912449 0 hsa-miR-1278_st 0.126417987 1.1 0.445945 0 hsa-miR-1279_st −0.181762902 1.1 0.306589 0 hsa-miR-409-3p_st −0.215378355 1.2 0.615119 0 hsa-miR-199a-5p_st −0.153644046 1.1 0.830237 0 hsa-miR-1281_st −0.416877219 1.3 0.051909 0 hsa-miR-1282_st −0.114126036 1.1 0.69452 0 hsa-miR-33b-star_st −0.311696271 1.2 0.064741 0 hsa-miR-1284_st 0.029751854 1.0 0.898056 0 hsa-miR-1253_st −0.207949898 1.2 0.313972 0 hsa-miR-584_st −0.414372924 1.3 0.136767 0 hsa-miR-1287_st 0.114178651 1.1 0.523653 0 hsa-miR-15a_st 1.807026676 3.5 2.43E−06 1 hsa-miR-1289_st −0.075351136 1.1 0.774966 0 hsa-miR-1290_st 0.154585932 1.1 0.612329 0 hsa-miR-2117_st −0.4678768 1.4 0.021404 1 hsa-miR-1292_st −0.473551934 1.4 0.006783 1 hsa-miR-1293_st −0.337402691 1.3 0.021723 1 hsa-miR-129-3p_st −0.063749598 1.0 0.756925 0 hsa-miR-520d-5p_st 0.117665596 1.1 0.57154 0 hsa-miR-526a_st 0.200592349 1.1 0.339392 0 hsa-miR-129-5p_st −0.145688178 1.1 0.358345 0 hsa-miR-1254_st −0.53796665 1.5 0.077597 0 hsa-miR-1297_st −0.23189402 1.2 0.169286 0 hsa-miR-1298_st −0.075777234 1.1 0.755096 0 hsa-miR-1299_st −0.249617214 1.2 0.598079 0 hsa-miR-129-star_st −0.052633967 1.0 0.802861 0 hsa-miR-1301_st −0.159684896 1.1 0.125708 0 hsa-miR-19b_st 1.451379133 2.7 2.02E−05 1 hsa-miR-1303_st 0.030203033 1.0 0.863646 0 hsa-miR-1304_st 0.008870957 1.0 0.979471 0 hsa-miR-1305_st −0.172064495 1.1 0.340802 0 hsa-miR-550_st −0.080479496 1.1 0.745654 0 hsa-miR-1307_st −0.28766034 1.2 0.078944 0 hsa-miR-1308_st 0.221936442 1.2 0.37792 0 hsa-miR-4291_st 0.771241259 1.7 0.007207 1 hsa-miR-130a-star_st 0.043246681 1.0 0.799175 0 hsa-miR-130b_st 0.306714001 1.2 0.359874 0 hsa-miR-130b-star_st 0.185794413 1.1 0.476992 0 hsa-miR-921_st −0.390782102 1.3 0.234679 0 hsa-miR-520a-5p_st −0.173424195 1.1 0.388112 0 hsa-miR-711_st −0.133322628 1.1 0.519927 0 hsa-miR-1323_st −0.312477393 1.2 0.116213 0 hsa-miR-1324_st −0.220231116 1.2 0.318216 0 hsa-miR-490-3p_st −0.25827324 1.2 0.17654 0 hsa-miR-718_st −0.461697063 1.4 0.026313 1 hsa-miR-133b_st −0.07985615 1.1 0.933955 0 hsa-miR-431-star_st −0.408662942 1.3 0.010748 1 hsa-miR-552_st −0.329687403 1.3 0.277994 0 hsa-miR-28-3p_st 0.880574763 1.8 0.072737 0 hsa-miR-4265_st −0.163278138 1.1 0.37954 0 hsa-miR-643_st −0.29977365 1.2 0.20083 0 hsa-miR-136_st −0.12132186 1.1 0.399267 0 hsa-miR-136-star_st −0.152368751 1.1 0.343058 0 hsa-miR-137_st −0.102684521 1.1 0.412208 0 hsa-miR-138_st −0.605925477 1.5 0.317351 0 hsa-miR-138-1-star_st −0.240945764 1.2 0.508704 0 hsa-miR-138-2-star_st 0.141983277 1.1 0.396209 0 hsa-miR-139-3p_st −0.131716305 1.1 0.54494 0 hsa-miR-139-5p_st −0.268734608 1.2 0.63242 0 hsa-miR-140-3p_st 0.197465852 1.1 0.503398 0 hsa-miR-140-5p_st 0.826693764 1.8 0.048991 1 hsa-miR-381_st 0.168334871 1.1 0.515567 0 hsa-miR-141-star_st 0.043126751 1.0 0.788021 0 hsa-miR-17-star_st 0.722778333 1.7 0.01285 1 hsa-miR-4300_st −0.08322793 1.1 0.670807 0 hsa-miR-143_st 0.387768109 1.3 0.302712 0 hsa-miR-143-star_st 0.382176259 1.3 0.355454 0 hsa-miR-144_st −0.097199106 1.1 0.578235 0 hsa-miR-3198_st −0.3358716 1.3 0.12322 0 hsa-miR-145_st −0.058239856 1.0 0.899497 0 hsa-miR-145-star_st 0.441691277 1.4 0.387584 0 hsa-miR-1468_st −0.089941631 1.1 0.636448 0 hsa-miR-1469_st −0.089331544 1.1 0.61786 0 hsa-miR-1973_st −0.34235067 1.3 0.42235 0 hsa-miR-3154_st −0.315751671 1.2 0.081374 0 hsa-miR-148a-star_st 0.318720552 1.2 0.409371 0 hsa-miR-92a-1-star_st −0.370453425 1.3 0.016293 1 hsa-miR-147_st −0.344570036 1.3 0.098676 0 hsa-miR-194-star_st −0.129448023 1.1 0.576788 0 hsa-miR-1471_st −0.651064872 1.6 0.038347 1 hsa-miR-147b_st −0.189832086 1.1 0.178474 0 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hsa-miR-15b-star_st −0.154561729 1.1 0.270312 0 hsa-miR-1266_st −0.36065288 1.3 0.088305 0 hsa-miR-16-1-star_st 0.041106483 1.0 0.733885 0 hsa-miR-16-2-star_st 0.088135904 1.1 0.772933 0 hsa-miR-490-5p_st −0.218094027 1.2 0.391697 0 hsa-miR-19a_st 1.168009101 2.2 0.006414 1 hsa-miR-3192_st −0.222235789 1.2 0.276692 0 hsa-miR-3155_st −0.324061844 1.3 0.14995 0 hsa-miR-187-star_st −0.422413005 1.3 0.009889 1 hsa-miR-16_st 1.052228302 2.1 0.000129 1 hsa-miR-936_st −0.116698523 1.1 0.443455 0 hsa-miR-181c-star_st −0.128046196 1.1 0.666287 0 hsa-miR-379_st 0.103915381 1.1 0.787539 0 hsa-miR-370_st −0.483340487 1.4 0.01525 1 hsa-miR-541_st −0.189869149 1.1 0.252191 0 hsa-miR-518c-star_st −0.031576082 1.0 0.855207 0 hsa-miR-487b_st 1.292259999 2.4 0.001643 1 hsa-miR-182-star_st 0.000264806 1.0 0.998582 0 hsa-miR-3121_st −0.254354348 1.2 0.595464 0 hsa-miR-3190-5p_st −0.192943008 1.1 0.256749 0 hsa-miR-1203_st −0.122799264 1.1 0.552063 0 hsa-miR-185_st 0.41879612 1.3 0.106428 0 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−0.11871377 1.1 0.637685 0 hsa-miR-1976_st 0.200978515 1.1 0.437262 0 hsa-miR-625-star_st −0.2984619 1.2 0.077316 0 hsa-miR-587_st −0.379036452 1.3 0.18636 0 hsa-miR-199a-3p_st −0.086977511 1.1 0.893946 0 hsa-miR-1910_st −0.280374108 1.2 0.061371 0 hsa-miR-199b-3p_st −0.085186759 1.1 0.90189 0 hsa-miR-639_st −0.633117298 1.6 0.004681 1 hsa-miR-1909-star_st −0.04954437 1.0 0.81209 0 hsa-miR-19a-star_st 0.023358024 1.0 0.910746 0 hsa-miR-29c-star_st 1.155865738 2.2 0.001798 1 hsa-miR-940_st −0.454260244 1.4 0.036272 1 hsa-miR-19b-2-star_st −0.101114755 1.1 0.440535 0 hsa-miR-4269_st 0.014021399 1.0 0.929756 0 hsa-miR-200a-star_st −0.274118588 1.2 0.347631 0 hsa-miR-1182_st −0.261863445 1.2 0.09322 0 hsa-miR-518f-star_st 0.205221025 1.2 0.22068 0 hsa-miR-92a-2-star_st −0.145559488 1.1 0.520364 0 hsa-miR-200c-star_st −0.061475953 1.0 0.757001 0 hsa-miR-202_st −0.495516659 1.4 0.032312 1 hsa-miR-202-star_st −0.113639918 1.1 0.574156 0 hsa-miR-1914-star_st −0.377571705 1.3 0.102503 0 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0.041149 1 hsa-miR-636_st −0.409250291 1.3 0.036468 1 hsa-miR-3177_st −0.379106948 1.3 0.035684 1 hsa-miR-1249_st −0.037996395 1.0 0.900178 0 hsa-miR-223-star_st 0.105811485 1.1 0.558056 0 hsa-miR-1224-5p_st −0.209188781 1.2 0.082302 0 hsa-miR-564_st −0.032944601 1.0 0.839399 0 hsa-miR-2276_st −0.217574237 1.2 0.398712 0 hsa-miR-2277_st −0.227538142 1.2 0.321315 0 hsa-miR-2278_st −0.266525885 1.2 0.180176 0 hsa-miR-22-star_st 1.398061863 2.6 0.007064 1 hsa-miR-2355_st −0.113098651 1.1 0.403945 0 hsa-miR-769-3p_st −0.163950585 1.1 0.531021 0 hsa-miR-1913_st −0.087377293 1.1 0.670422 0 hsa-miR-1237_st −0.156005014 1.1 0.483759 0 hsa-miR-1275_st −0.182473605 1.1 0.245485 0 hsa-miR-30a_st 1.024729276 2.0 0.00251 1 hsa-miR-20b-star_st −0.057160051 1.0 0.842689 0 hsa-miR-24-2-star_st 0.586785533 1.5 0.109135 0 hsa-miR-3173_st −0.099329894 1.1 0.533755 0 hsa-miR-3148_st −0.021975634 1.0 0.917253 0 hsa-miR-4271_st −0.222495069 1.2 0.318823 0 hsa-miR-659_st −0.288319897 1.2 0.028321 1 hsa-miR-26a-2-star_st 0.149258411 1.1 0.390824 0 hsa-miR-1228_st −0.315200757 1.2 0.165415 0 hsa-miR-26b-star_st 0.367285802 1.3 0.207723 0 hsa-miR-3174_st −0.077758999 1.1 0.816929 0 hsa-miR-27a-star_st 0.129101911 1.1 0.681076 0 hsa-miR-1285_st 0.002028737 1.0 0.990615 0 hsa-miR-483-5p_st −0.103887481 1.1 0.48891 0 hsa-miR-1306_st −0.372007961 1.3 0.056927 0 hsa-miR-431_st 0.073637654 1.1 0.692312 0 hsa-miR-765_st −0.083915062 1.1 0.439635 0 hsa-miR-2909_st −0.044400927 1.0 0.802129 0 hsa-miR-296-3p_st −0.317483684 1.2 0.021269 1 hsa-miR-296-5p_st 0.103216593 1.1 0.630197 0 hsa-miR-297_st −0.09159831 1.1 0.748298 0 hsa-miR-323b-5p_st −0.074971997 1.1 0.731642 0 hsa-miR-299-3p_st −0.357201162 1.3 0.16969 0 hsa-miR-299-5p_st 0.113927724 1.1 0.835393 0 hsa-miR-487a_st 0.484682834 1.4 0.022022 1 hsa-miR-29a-star_st −0.201991506 1.2 0.192164 0 hsa-miR-625_st 0.02015697 1.0 0.897879 0 hsa-miR-611_st −0.047362374 1.0 0.823486 0 hsa-miR-3186-3p_st 0.321723361 1.2 0.081443 0 hsa-miR-1294_st 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hsa-miR-3172_st 0.198219006 1.1 0.398746 0 hsa-miR-374b-star_st 0.27582399 1.2 0.2106 0 hsa-miR-34c-5p_st 0.006784123 1.0 0.95611 0 hsa-miR-758_st 0.025012445 1.0 0.954295 0 hsa-miR-3176_st −0.171286239 1.1 0.45875 0 hsa-miR-606_st 0.033641561 1.0 0.793768 0 hsa-miR-3178_st −0.176082124 1.1 0.157413 0 hsa-miR-3179_st −0.217618667 1.2 0.34018 0 hsa-miR-3180-3p_st −0.214070669 1.2 0.244807 0 hsa-miR-597_st 0.067309683 1.0 0.685759 0 hsa-miR-148b-star_st 0.212870465 1.2 0.259304 0 hsa-miR-3182_st −0.049737974 1.0 0.844819 0 hsa-miR-3183_st −0.294270331 1.2 0.125399 0 hsa-miR-144-star_st 0.113165889 1.1 0.588758 0 hsa-miR-3185_st −0.24583669 1.2 0.102708 0 hsa-miR-4270_st −0.227001765 1.2 0.047192 1 hsa-miR-3186-5p_st −0.161680845 1.1 0.416834 0 hsa-miR-3187_st −0.310333812 1.2 0.041588 1 hsa-miR-3188_st −0.26162614 1.2 0.054989 0 hsa-miR-3189_st −0.308532372 1.2 0.165767 0 hsa-miR-548b-3p_st −0.202028411 1.2 0.447298 0 hsa-miR-99a-star_st 0.008591644 1.0 0.985091 0 hsa-miR-376a-star_st −0.262366127 1.2 0.175589 0 hsa-miR-216b_st 0.109811539 1.1 0.475646 0 hsa-miR-3193_st −0.1455925 1.1 0.494757 0 hsa-miR-548v_st −0.127431689 1.1 0.310566 0 hsa-miR-26a-1-star_st −0.172882256 1.1 0.12082 0 hsa-miR-1291_st 0.033813753 1.0 0.923764 0 hsa-miR-3197_st −0.2752107 1.2 0.173261 0 hsa-miR-629_st 0.322102816 1.3 0.14937 0 hsa-miR-3199_st −0.086750107 1.1 0.77707 0 hsa-miR-190b_st 0.037973005 1.0 0.812507 0 hsa-miR-32_st 0.054203066 1.0 0.793567 0 hsa-miR-3200_st 0.370776003 1.3 0.26748 0 hsa-miR-3201_st −0.224802742 1.2 0.134516 0 hsa-miR-3202_st −0.037381252 1.0 0.868966 0 hsa-miR-320a_st 0.088642076 1.1 0.580585 0 hsa-miR-4289_st 0.353834194 1.3 0.217778 0 hsa-miR-655_st 0.098646879 1.1 0.511802 0 hsa-miR-320b_st 0.190618529 1.1 0.414674 0 hsa-miR-219-5p_st 0.138005098 1.1 0.57633 0 hsa-miR-323-3p_st −0.118105522 1.1 0.480847 0 hsa-miR-323-5p_st −0.281204668 1.2 0.210072 0 hsa-miR-323b-3p_st −0.199954115 1.1 0.294963 0 hsa-miR-103-as_st 0.327763771 1.3 0.042037 1 hsa-miR-424-star_st −0.079178446 1.1 0.708366 0 hsa-miR-33a-star_st 0.621673223 1.5 0.08119 0 hsa-miR-325_st −0.25410997 1.2 0.321 0 hsa-miR-590-3p_st −0.250220762 1.2 0.051087 0 hsa-miR-328_st 0.47942705 1.4 0.388897 0 hsa-miR-329_st 0.402623233 1.3 0.33579 0 hsa-miR-32-star_st −0.144735608 1.1 0.398804 0 hsa-miR-330-3p_st 0.296420533 1.2 0.319573 0 hsa-miR-330-5p_st −0.358556796 1.3 0.101513 0 hsa-miR-146a-star_st 0.132936281 1.1 0.436562 0 hsa-miR-331-5p_st 0.214925835 1.2 0.293243 0 hsa-miR-3167_st −0.380514101 1.3 0.011104 1 hsa-miR-335-star_st −0.113347924 1.1 0.667181 0 hsa-miR-337-3p_st −0.299917588 1.2 0.241301 0 hsa-miR-337-5p_st 0.098607674 1.1 0.53292 0 hsa-miR-421_st 0.981238385 2.0 0.000564 1 hsa-miR-338-5p_st 0.250102197 1.2 0.349619 0 hsa-miR-339-3p_st 0.215123252 1.2 0.207802 0 hsa-miR-548a-5p_st 0.173615523 1.1 0.219936 0 hsa-miR-33a_st −0.183834199 1.1 0.194999 0 hsa-miR-590-5p_st 0.429675725 1.3 0.049476 1 hsa-miR-33b_st 0.006619555 1.0 0.959539 0 hsa-miR-616-star_st 0.140218818 1.1 0.535721 0 hsa-miR-569_st −0.343456236 1.3 0.024866 1 hsa-miR-340-star_st 0.050611491 1.0 0.818365 0 hsa-miR-342-3p_st 0.74806875 1.7 0.117205 0 hsa-miR-135b-star_st −0.229794648 1.2 0.370114 0 hsa-miR-345_st 0.650838824 1.6 0.306431 0 hsa-miR-1288_st −0.35239905 1.3 0.031557 1 hsa-miR-135a_st −0.255753253 1.2 0.206675 0 hsa-miR-34a-star_st 0.54743006 1.5 0.247337 0 hsa-miR-34b_st 0.226778338 1.2 0.487582 0 hsa-miR-4288_st 0.168978062 1.1 0.452641 0 hsa-miR-222-star_st 0.455608482 1.4 0.331792 0 hsa-miR-933_st 0.661721296 1.6 0.043657 1 hsa-miR-361-3p_st 0.362386662 1.3 0.321141 0 hsa-miR-224-star_st 0.349123832 1.3 0.278402 0 hsa-miR-362-3p_st 0.846074367 1.8 0.054201 0 hsa-miR-362-5p_st 0.730868032 1.7 0.068527 0 hsa-miR-363_st 0.902059941 1.9 0.19095 0 hsa-miR-363-star_st −0.243662075 1.2 0.260103 0 hsa-miR-1979_st 0.210717114 1.2 0.319255 0 hsa-miR-365-star_st −0.250262759 1.2 0.062003 0 hsa-miR-548x_st −0.222452328 1.2 0.103741 0 hsa-miR-367-star_st −0.009449646 1.0 0.960316 0 hsa-miR-369-3p_st −0.137924493 1.1 0.493441 0 hsa-miR-369-5p_st 0.413624974 1.3 0.275731 0 hsa-miR-548l_st −0.462858659 1.4 0.010697 1 hsa-miR-371-3p_st −0.314238581 1.2 0.032169 1 hsa-miR-371-5p_st −0.329699988 1.3 0.012149 1 hsa-miR-372_st −0.449063987 1.4 0.064932 0 hsa-miR-373_st −0.001210024 1.0 0.995358 0 hsa-miR-373-star_st −0.241266808 1.2 0.146947 0 hsa-miR-374a_st 1.012265854 2.0 0.063571 0 hsa-miR-374a-star_st 0.319878832 1.2 0.063397 0 hsa-miR-500_st 0.234083858 1.2 0.520834 0 hsa-miR-320c_st 0.347070909 1.3 0.20656 0 hsa-miR-875-3p_st −0.294945917 1.2 0.01005 1 hsa-miR-376a_st 0.20239319 1.2 0.628111 0 hsa-miR-29b-1-star_st 1.039006533 2.1 0.001431 1 hsa-miR-376b_st 0.069831205 1.0 0.830814 0 hsa-miR-376c_st 0.215460011 1.2 0.73194 0 hsa-miR-377_st −0.254715874 1.2 0.453781 0 hsa-miR-377-star_st −0.090396435 1.1 0.721982 0 hsa-miR-378_st 0.190166057 1.1 0.754105 0 hsa-miR-378b_st −0.075184996 1.1 0.639191 0 hsa-miR-378c_st 0.393349144 1.3 0.358202 0 hsa-miR-378-star_st 0.619597439 1.5 0.132812 0 hsa-miR-662_st 0.644523647 1.6 0.006265 1 hsa-miR-379-star_st 0.052880072 1.0 0.758413 0 hsa-miR-380_st −0.132147415 1.1 0.40427 0 hsa-miR-380-star_st −0.080819037 1.1 0.559834 0 hsa-miR-1274b_st 0.692029878 1.6 0.008033 1 hsa-miR-382_st −0.079664111 1.1 0.866517 0 hsa-miR-383_st −0.19512361 1.1 0.352773 0 hsa-miR-384_st −0.02150677 1.0 0.903645 0 hsa-miR-126-star_st −0.078586982 1.1 0.638543 0 hsa-miR-409-5p_st 0.280141855 1.2 0.284478 0 hsa-miR-410_st 0.060231608 1.0 0.748033 0 hsa-miR-411_st −0.009065099 1.0 0.971273 0 hsa-miR-411-star_st 0.054650659 1.0 0.833063 0 hsa-miR-412_st −0.349362245 1.3 0.075651 0 hsa-miR-3143_st −0.309343561 1.2 0.053479 0 hsa-miR-422a_st 0.480802988 1.4 0.228163 0 hsa-miR-628-5p_st −0.010807438 1.0 0.956414 0 hsa-miR-423-5p_st −0.158291648 1.1 0.144523 0 hsa-miR-27b-star_st 1.144934747 2.2 0.000137 1 hsa-miR-499-5p_st 0.537593512 1.5 0.061637 0 hsa-miR-425_st 1.152232207 2.2 0.021107 1 hsa-miR-193b_st 0.777218989 1.7 0.188445 0 hsa-miR-4252_st −0.237928146 1.2 0.037826 1 hsa-miR-4253_st −0.07441884 1.1 0.624666 0 hsa-miR-4254_st 0.341356072 1.3 0.241972 0 hsa-miR-324-3p_st 0.159767742 1.1 0.5027 0 hsa-miR-4329_st 0.122056788 1.1 0.521979 0 hsa-miR-1251_st 0.49059833 1.4 0.292208 0 hsa-miR-4258_st −0.486496757 1.4 0.057511 0 hsa-miR-1274a_st 1.454236267 2.7 0.004247 1 hsa-miR-425-star_st 0.121147214 1.1 0.487547 0 hsa-miR-4260_st −0.308871356 1.2 0.072652 0 hsa-miR-4261_st −0.150753977 1.1 0.407443 0 hsa-miR-4262_st −0.284692167 1.2 0.047952 1 hsa-miR-4263_st −0.228452731 1.2 0.109873 0 hsa-miR-4264_st −0.318087101 1.2 0.066803 0 hsa-miR-1280_st 0.419569178 1.3 0.086435 0 hsa-miR-132-star_st 0.626048779 1.5 0.322813 0 hsa-miR-4267_st −0.344890704 1.3 0.179689 0 hsa-miR-4268_st −0.338895549 1.3 0.10181 0 hsa-miR-133a_st −0.109694948 1.1 0.906966 0 hsa-miR-888-star_st −0.33178815 1.3 0.058608 0 hsa-miR-1260b_st 0.497739532 1.4 0.040396 1 hsa-miR-4272_st 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hsa-miR-1246_st 0.414736319 1.3 0.124844 0 hsa-miR-4295_st 0.07492555 1.1 0.694571 0 hsa-miR-4296_st −0.294484043 1.2 0.094351 0 hsa-miR-4297_st −0.148250227 1.1 0.631538 0 hsa-miR-4298_st −0.083908186 1.1 0.575612 0 hsa-miR-218_st 1.200331744 2.3 0.024175 1 hsa-miR-4286_st 0.962915116 1.9 0.002423 1 hsa-miR-4301_st −0.248467648 1.2 0.276115 0 hsa-miR-4302_st −0.377015037 1.3 0.065229 0 hsa-miR-365_st 0.275158224 1.2 0.558456 0 hsa-miR-4304_st −0.05156377 1.0 0.861577 0 hsa-miR-4305_st −0.170667826 1.1 0.422615 0 hsa-miR-4306_st 0.153490115 1.1 0.455602 0 hsa-miR-26a_st 0.461851114 1.4 0.058941 0 hsa-miR-4308_st 0.24652506 1.2 0.29665 0 hsa-miR-4309_st −0.067603752 1.0 0.552812 0 hsa-miR-186_st 0.965710015 2.0 0.082184 0 hsa-miR-4310_st −0.67444314 1.6 0.065911 0 hsa-miR-4311_st −0.02217425 1.0 0.930599 0 hsa-miR-4312_st −0.18012942 1.1 0.524654 0 hsa-miR-4313_st −0.109956685 1.1 0.571521 0 hsa-miR-4314_st −0.408820848 1.3 0.313019 0 hsa-miR-4315_st −0.245040873 1.2 0.290623 0 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0.779874 0 hsa-miR-449c_st −0.635656977 1.6 0.008109 1 hsa-miR-449c-star_st −0.354961117 1.3 0.131696 0 hsa-miR-1_st 0.327935748 1.3 0.691217 0 hsa-miR-450b-3p_st −0.275368593 1.2 0.055715 0 hsa-miR-450b-5p_st −0.201914769 1.2 0.298211 0 hsa-miR-451_st 0.29874469 1.2 0.60144 0 hsa-miR-452_st 0.394662974 1.3 0.163805 0 hsa-miR-452-star_st −0.116804787 1.1 0.320648 0 hsa-miR-548b-5p_st −0.415522331 1.3 0.047547 1 hsa-miR-454-star_st 0.090584749 1.1 0.684641 0 hsa-miR-455-3p_st 0.72695679 1.7 0.157444 0 hsa-miR-455-5p_st 0.745611668 1.7 0.113269 0 hsa-miR-466_st −0.002378655 1.0 0.9908 0 hsa-miR-483-3p_st −0.002771205 1.0 0.989313 0 hsa-miR-17_st 1.004134411 2.0 0.005165 1 hsa-miR-320d_st 0.541005035 1.5 0.125703 0 hsa-miR-485-3p_st 0.38483216 1.3 0.236994 0 hsa-miR-485-5p_st −0.075896024 1.1 0.656094 0 hsa-miR-486-3p_st −0.146028046 1.1 0.547445 0 hsa-miR-486-5p_st −0.521624073 1.4 0.434867 0 hsa-miR-644_st −0.453405252 1.4 0.014361 1 hsa-miR-3152_st −0.597763677 1.5 0.00553 1 hsa-miR-488_st −0.094910267 1.1 0.556745 0 hsa-miR-488-star_st −0.168114905 1.1 0.239729 0 hsa-miR-450a_st 0.878998262 1.8 0.056476 0 hsa-miR-20a_st 1.357218447 2.6 0.00111 1 hsa-miR-484_st 0.997234163 2.0 0.022629 1 hsa-miR-491-3p_st −0.117083314 1.1 0.579589 0 hsa-miR-491-5p_st −0.256430323 1.2 0.295795 0 hsa-miR-197_st 0.153738709 1.1 0.747248 0 hsa-miR-493_st 0.246347842 1.2 0.276198 0 hsa-miR-493-star_st 0.432261825 1.3 0.362606 0 hsa-miR-494_st −0.332715091 1.3 0.342793 0 hsa-miR-495_st 0.644282003 1.6 0.163043 0 hsa-miR-496_st −0.121088859 1.1 0.415413 0 hsa-miR-497_st 0.688563468 1.6 0.167353 0 hsa-miR-497-star_st −0.190441169 1.1 0.124663 0 hsa-miR-498_st −0.173247862 1.1 0.331489 0 hsa-miR-499-3p_st 0.099334322 1.1 0.348574 0 hsa-miR-24-1-star_st 0.477250912 1.4 0.088102 0 hsa-miR-340_st 1.756826151 3.4 0.003883 1 hsa-miR-500b_st 0.37849067 1.3 0.098823 0 hsa-miR-500-star_st 0.114575453 1.1 0.450079 0 hsa-miR-501-3p_st −0.110373115 1.1 0.296713 0 hsa-miR-501-5p_st 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−0.090063164 1.1 0.56881 0 hsa-miR-519a_st −0.252786209 1.2 0.122184 0 hsa-miR-519a-star_st 0.092211681 1.1 0.68124 0 hsa-miR-519b-3p_st −0.114245101 1.1 0.552331 0 hsa-miR-1283_st −0.469487431 1.4 0.00146 1 hsa-miR-519c-3p_st −0.245942745 1.2 0.251864 0 hsa-miR-519c-5p_st 0.115575913 1.1 0.62724 0 hsa-miR-519d_st −0.163140403 1.1 0.252884 0 hsa-miR-519e_st 0.129353681 1.1 0.548914 0 hsa-miR-519e-star_st −0.022303865 1.0 0.904033 0 hsa-miR-520a-3p_st −0.117170806 1.1 0.544033 0 hsa-miR-1908_st −0.061572109 1.0 0.742666 0 hsa-miR-520b_st −0.042398359 1.0 0.757818 0 hsa-miR-520c-3p_st 0.12741139 1.1 0.395223 0 hsa-miR-520c-5p_st 0.325644192 1.3 0.144279 0 hsa-miR-181a-star_st 1.066648028 2.1 0.026636 1 hsa-miR-21_st 1.701918012 3.3 0.003731 1 hsa-miR-520e_st −0.169893218 1.1 0.31581 0 hsa-miR-520f_st 0.103649443 1.1 0.569346 0 hsa-miR-520g_st 0.024343564 1.0 0.920078 0 hsa-miR-520h_st −0.15017653 1.1 0.352571 0 hsa-miR-521_st −0.002991683 1.0 0.987167 0 hsa-miR-302a-star_st −0.411085649 1.3 0.006121 1 hsa-miR-886-3p_st 0.939607637 1.9 0.094772 0 hsa-miR-523_st −0.337970193 1.3 0.107975 0 hsa-miR-29a_st 1.2319824 2.3 0.000329 1 hsa-miR-524-3p_st −0.320499202 1.2 0.011902 1 hsa-miR-142-3p_st −0.438969781 1.4 0.008531 1 hsa-miR-525-3p_st −0.39413845 1.3 0.048847 1 hsa-miR-525-5p_st 0.30479135 1.2 0.129595 0 hsa-miR-762_st −0.083493328 1.1 0.633601 0 hsa-miR-423-3p_st 0.711073882 1.6 0.017649 1 hsa-miR-449b-star_st −0.123220301 1.1 0.577831 0 hsa-miR-527_st −0.026625226 1.0 0.911283 0 hsa-miR-532-3p_st 0.540568774 1.5 0.126344 0 hsa-miR-532-5p_st 0.731613762 1.7 0.025591 1 hsa-miR-539_st −0.018830432 1.0 0.948402 0 hsa-let-7a_st 0.55204636 1.5 0.020682 1 hsa-miR-541-star_st −0.109865546 1.1 0.460317 0 hsa-miR-542-3p_st 0.387574158 1.3 0.457678 0 hsa-miR-542-5p_st 0.284172013 1.2 0.138411 0 hsa-miR-543_st 0.20446825 1.2 0.528457 0 hsa-miR-544_st −0.202343739 1.2 0.173628 0 hsa-miR-544b_st −0.253850799 1.2 0.034089 1 hsa-miR-545_st −0.136117108 1.1 0.486843 0 hsa-miR-545-star_st −0.020733575 1.0 0.925047 0 hsa-miR-548a-3p_st −0.333045477 1.3 0.140219 0 hsa-miR-2861_st −0.099423093 1.1 0.56761 0 hsa-miR-31_st −0.109783603 1.1 0.921003 0 hsa-miR-367_st −0.378471209 1.3 0.063538 0 hsa-miR-548c-3p_st −0.186050898 1.1 0.444477 0 hsa-miR-548c-5p_st 0.176010745 1.1 0.593144 0 hsa-miR-548d-3p_st −0.223879669 1.2 0.142763 0 hsa-miR-548d-5p_st 0.036623603 1.0 0.885945 0 hsa-miR-548e_st −0.080672478 1.1 0.526272 0 hsa-miR-548f_st −0.048696998 1.0 0.727798 0 hsa-miR-548g_st −0.100754796 1.1 0.620972 0 hsa-miR-548h_st 0.256969314 1.2 0.210166 0 hsa-miR-548i_st −0.204849676 1.2 0.215507 0 hsa-miR-548j_st −0.268777248 1.2 0.275809 0 hsa-miR-548k_st −0.105556905 1.1 0.320016 0 hsa-miR-526b-star_st −0.390518138 1.3 0.016474 1 hsa-miR-548m_st −0.05771275 1.0 0.660989 0 hsa-miR-548n_st 0.028413019 1.0 0.810969 0 hsa-miR-548o_st −0.153729074 1.1 0.314199 0 hsa-miR-548p_st −0.194119527 1.1 0.319165 0 hsa-miR-548q_st −0.281681877 1.2 0.229742 0 hsa-miR-548s_st 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−0.187165458 1.1 0.280274 0 hsa-miR-361-5p_st 0.723844648 1.7 0.03287 1 hsa-miR-566_st −0.130903377 1.1 0.346761 0 hsa-miR-567_st −0.401702551 1.3 0.157023 0 hsa-miR-568_st −0.20566138 1.2 0.220733 0 hsa-miR-29c_st 1.326485605 2.5 0.000467 1 hsa-miR-570_st −0.102974732 1.1 0.404312 0 hsa-miR-571_st −0.306693555 1.2 0.106421 0 hsa-miR-572_st −0.424231993 1.3 0.003436 1 hsa-miR-573_st −0.085227674 1.1 0.518144 0 hsa-miR-132_st 1.114746429 2.2 0.07689 0 hsa-miR-574-5p_st 0.136408684 1.1 0.393694 0 hsa-let-7d_st 0.61890098 1.5 0.014918 1 hsa-miR-576-3p_st −0.143494699 1.1 0.515039 0 hsa-miR-576-5p_st −0.049197078 1.0 0.834912 0 hsa-miR-577_st −0.218217894 1.2 0.260749 0 hsa-miR-578_st −0.103644333 1.1 0.465353 0 hsa-miR-579_st −0.156269307 1.1 0.246716 0 hsa-miR-580_st −0.211660157 1.2 0.154681 0 hsa-miR-191_st 0.87234231 1.8 0.011941 1 hsa-miR-582-3p_st −0.243485005 1.2 0.073892 0 hsa-miR-582-5p_st −0.170330076 1.1 0.648452 0 hsa-miR-1915_st −0.072399572 1.1 0.702103 0 hsa-let-7c_st 0.517563473 1.4 0.061755 0 hsa-miR-585_st −0.211688096 1.2 0.159342 0 hsa-miR-586_st −0.14429517 1.1 0.360386 0 hsa-miR-324-5p_st 0.988319838 2.0 0.012885 1 hsa-miR-588_st −0.167131422 1.1 0.332784 0 hsa-miR-589_st 0.218479222 1.2 0.252838 0 hsa-miR-589-star_st −0.00641305 1.0 0.973753 0 hsa-miR-188-5p_st −0.296936153 1.2 0.219384 0 hsa-miR-103_st 1.03523233 2.0 0.001823 1 hsa-miR-591_st −0.143378031 1.1 0.419704 0 hsa-miR-592_st 0.130916791 1.1 0.591192 0 hsa-miR-593_st −0.186610547 1.1 0.243335 0 hsa-miR-23b_st 0.721602597 1.6 0.010104 1 hsa-miR-595_st −0.31487096 1.2 0.041805 1 hsa-miR-99a_st 0.495327316 1.4 0.300085 0 hsa-miR-15b_st 0.947101333 1.9 0.061733 0 hsa-miR-135b_st 0.546460614 1.5 0.155533 0 hsa-miR-599_st −0.030449943 1.0 0.882528 0 hsa-miR-600_st 0.13457278 1.1 0.618444 0 hsa-miR-107_st 1.141220602 2.2 0.000543 1 hsa-miR-602_st −0.187890095 1.1 0.172407 0 hsa-miR-603_st 0.006426969 1.0 0.95885 0 hsa-miR-3065-5p_st 0.373447558 1.3 0.474244 0 hsa-miR-605_st −0.321490282 1.2 0.166105 0 hsa-miR-24_st 0.87897293 1.8 0.005853 1 hsa-miR-607_st −0.017611727 1.0 0.891842 0 hsa-miR-608_st −0.279737283 1.2 0.059528 0 hsa-miR-609_st 0.064318178 1.0 0.648074 0 hsa-miR-3196_st −0.071836039 1.1 0.704866 0 hsa-miR-26b_st 1.226846823 2.3 0.000933 1 hsa-miR-28-5p_st 1.073394755 2.1 0.000182 1 hsa-miR-613_st −0.209291608 1.2 0.15186 0 hsa-miR-338-3p_st 0.957359286 1.9 0.097284 0 hsa-miR-615-3p_st −0.096389676 1.1 0.632522 0 hsa-miR-454_st 1.776242983 3.4 0.000106 1 hsa-miR-616_st 0.119423732 1.1 0.566473 0 hsa-miR-151-5p_st 0.838212927 1.8 0.001664 1 hsa-miR-617_st −0.127688369 1.1 0.718503 0 hsa-miR-128_st 1.619243053 3.1 0.001426 1 hsa-miR-619_st −0.19470032 1.1 0.183164 0 hsa-miR-620_st −0.245720876 1.2 0.08194 0 hsa-miR-621_st 0.051903003 1.0 0.736618 0 hsa-let-7b_st 0.430340932 1.3 0.295475 0 hsa-miR-623_st −0.285538852 1.2 0.032673 1 hsa-miR-624_st −0.157975269 1.1 0.224917 0 hsa-miR-624-star_st 0.049249659 1.0 0.850798 0 hsa-miR-183_st 1.835228439 3.6 0.002511 1 hsa-miR-30b_st 1.133882973 2.2 4.01E−05 1 hsa-miR-626_st −0.192364715 1.1 0.207714 0 hsa-miR-627_st −0.087366785 1.1 0.618808 0 hsa-miR-628-3p_st −0.271739776 1.2 0.559436 0 hsa-miR-31-star_st 0.236736977 1.2 0.827676 0 hsa-miR-218-1-star_st −0.464921904 1.4 0.014686 1 hsa-miR-629-star_st 0.586676814 1.5 0.015252 1 hsa-miR-630_st −0.329334252 1.3 0.338323 0 hsa-miR-631_st −0.207329239 1.2 0.577404 0 hsa-miR-632_st −0.175176225 1.1 0.448362 0 hsa-miR-633_st −0.129368301 1.1 0.354536 0 hsa-miR-634_st −0.123472246 1.1 0.746401 0 hsa-miR-635_st −0.318392819 1.2 0.195233 0 hsa-miR-203_st 1.107326704 2.2 0.168882 0 hsa-miR-331-3p_st 0.908208225 1.9 0.009822 1 hsa-miR-125b_st 0.377703553 1.3 0.174537 0 hsa-let-7i_st 0.533948377 1.4 0.108245 0 hsa-miR-640_st −0.173838782 1.1 0.282929 0 hsa-miR-641_st −0.021242719 1.0 0.931745 0 hsa-miR-642_st −0.225540976 1.2 0.117825 0 hsa-miR-29b_st 1.543794907 2.9 0.000862 1 hsa-miR-122_st −0.746781919 1.7 0.005368 1 hsa-miR-645_st −0.113881606 1.1 0.391144 0 hsa-miR-646_st −0.004961891 1.0 0.976605 0 hsa-miR-647_st −0.256501841 1.2 0.072392 0 hsa-miR-648_st −0.324997991 1.3 0.069872 0 hsa-miR-649_st −0.118040565 1.1 0.651879 0 hsa-miR-182_st 2.261841464 4.8 0.000109 1 hsa-miR-651_st −0.277324586 1.2 0.064918 0 hsa-miR-652_st 0.115362604 1.1 0.701592 0 hsa-miR-653_st −0.0362333 1.0 0.803638 0 hsa-miR-654-3p_st 0.309176672 1.2 0.595322 0 hsa-miR-374b_st 1.527265203 2.9 0.000203 1 hsa-miR-130a_st 1.012685312 2.0 0.003332 1 hsa-miR-656_st −0.279584019 1.2 0.075387 0 hsa-miR-657_st −0.145126125 1.1 0.414567 0 hsa-miR-658_st −0.065261546 1.0 0.710103 0 hsa-miR-99b_st 0.87169929 1.8 0.015517 1 hsa-miR-660_st 1.25280201 2.4 0.010184 1 hsa-miR-661_st −0.463110155 1.4 0.01184 1 hsa-miR-30e-star_st 1.078393814 2.1 0.030312 1 hsa-miR-663_st −0.141240934 1.1 0.388094 0 hsa-miR-663b_st −0.331507669 1.3 0.07095 0 hsa-miR-664_st 0.64242781 1.6 0.067628 0 hsa-miR-664-star_st 0.037623658 1.0 0.905561 0 hsa-miR-30d_st 0.891398972 1.9 0.001523 1 hsa-miR-668_st 0.0355101 1.0 0.880699 0 hsa-miR-670_st −0.44167641 1.4 0.058068 0 hsa-miR-671-3p_st 0.402943707 1.3 0.072075 0 hsa-miR-671-5p_st −0.228509395 1.2 0.060662 0 hsa-miR-30a-star_st 0.9088967 1.9 0.061902 0 hsa-miR-675-star_st −0.087143839 1.1 0.678958 0 hsa-miR-148b_st 1.316705685 2.5 0.001399 1 hsa-miR-708_st 0.442310645 1.4 0.460724 0 hsa-miR-708-star_st −0.153204931 1.1 0.327227 0 hsa-miR-221-star_st 0.983264586 2.0 0.143558 0 hsa-let-7e_st 0.948058979 1.9 0.005447 1 hsa-miR-7-1-star_st 0.981989019 2.0 0.010849 1 hsa-miR-27b_st 1.261757032 2.4 3.78E−05 1 hsa-miR-34a_st 0.933616594 1.9 0.091903 0 hsa-miR-744_st −0.270649582 1.2 0.092488 0 hsa-miR-744-star_st 0.288186931 1.2 0.137449 0 hsa-miR-92b_st 0.872168985 1.8 0.120481 0 hsa-miR-759_st −0.089503751 1.1 0.612669 0 hsa-miR-760_st −0.222119663 1.2 0.264488 0 hsa-miR-92a_st 0.906781037 1.9 0.063877 0 hsa-miR-335_st 1.766976679 3.4 0.000147 1 hsa-miR-96_st 2.48100936 5.6 0.000106 1 hsa-miR-95_st 1.268105136 2.4 0.007847 1 hsa-miR-766_st 0.078595833 1.1 0.651704 0 hsa-miR-767-3p_st −0.207466952 1.2 0.091216 0 hsa-miR-767-5p_st 0.022662849 1.0 0.894326 0 hsa-miR-98_st 1.32058169 2.5 0.001374 1 hsa-miR-769-5p_st 0.423470618 1.3 0.17277 0 hsa-miR-770-5p_st 0.094198435 1.1 0.657278 0 hsa-miR-802_st −0.125411804 1.1 0.373819 0 hsa-miR-34b-star_st 1.232597395 2.3 0.018786 1 hsa-miR-581_st −0.468929481 1.4 0.074222 0 hsa-miR-181d_st 0.836844503 1.8 0.016099 1 hsa-miR-875-5p_st −0.162558773 1.1 0.342197 0 hsa-miR-876-3p_st −0.12123653 1.1 0.435903 0 hsa-miR-876-5p_st −0.298559327 1.2 0.124951 0 hsa-miR-151-3p_st 1.432754576 2.7 1.19E−05 1 hsa-miR-877-star_st −0.290268099 1.2 0.269744 0 hsa-miR-885-3p_st −0.254669598 1.2 0.248955 0 hsa-miR-200c_st 0.839055271 1.8 0.001917 1 hsa-miR-429_st 0.572430596 1.5 0.398287 0 hsa-miR-886-5p_st 0.174128208 1.1 0.589378 0 hsa-miR-224_st 1.621362833 3.1 0.007637 1 hsa-miR-888_st −0.086292979 1.1 0.680565 0 hsa-miR-4321_st −0.626340887 1.5 0.003939 1 hsa-miR-889_st −0.250034899 1.2 0.125379 0 hsa-miR-181b_st 0.978114411 2.0 0.006642 1 hsa-miR-891a_st 0.281716938 1.2 0.282343 0 hsa-miR-891b_st 0.049144674 1.0 0.793571 0 hsa-miR-892a_st −0.115793847 1.1 0.712346 0 hsa-miR-892b_st 0.037081424 1.0 0.839625 0 hsa-miR-9_st −0.158311541 1.1 0.338581 0 hsa-miR-222_st 1.115543372 2.2 0.13968 0 hsa-miR-141_st 1.558355536 2.9 0.000125 1 hsa-miR-221_st 1.258954423 2.4 0.065194 0 hsa-miR-924_st −0.020805508 1.0 0.842695 0 hsa-miR-181a_st 1.043508083 2.1 0.025651 1 hsa-miR-181c_st 1.190333118 2.3 0.012976 1 hsa-miR-4324_st 0.773648613 1.7 0.105104 0 hsa-miR-125a-5p_st 0.727273781 1.7 0.101279 0 hsa-miR-92b-star_st −0.200995148 1.1 0.115034 0 hsa-miR-3195_st −0.692116959 1.6 0.001413 1 hsa-miR-3137_st −0.704564764 1.6 0.007236 1 hsa-miR-934_st −0.096561033 1.1 0.66635 0 hsa-miR-935_st −0.134684525 1.1 0.62588 0 hsa-miR-551b_st 1.07431732 2.1 0.23796 0 hsa-miR-937_st −0.133324731 1.1 0.63771 0 hsa-miR-938_st −0.038256447 1.0 0.82499 0 hsa-miR-939_st −0.285106046 1.2 0.033987 1 hsa-miR-7-2-star_st −0.23839895 1.2 0.731844 0 hsa-miR-146b-5p_st 1.753845263 3.4 0.055515 0 hsa-miR-941_st −0.200227377 1.1 0.324271 0 hsa-miR-942_st −0.11890718 1.1 0.502054 0 hsa-miR-200a_st 0.078917251 1.1 0.930234 0 hsa-miR-944_st −0.031230587 1.0 0.878163 0 hsa-miR-7_st −0.991336009 2.0 0.442726 0 hsa-miR-375_st 0.552650418 1.5 0.127734 0 hsa-miR-96-star_st 0.094358029 1.1 0.644533 0 hsa-miR-424_st 1.978545967 3.9 0.004507 1 hsa-miR-181a-2-star_st 1.726391112 3.3 0.000884 1 hsa-miR-200b_st 0.049617782 1.0 0.955056 0 hsa-miR-146b-3p_st 0.855192214 1.8 0.232998 0 hsa-miR-99b-star_st −0.008670433 1.0 0.964416 0 hsa-miR-9-star_st −0.121290889 1.1 0.610079 0 Log2Diff fold change Sample Name (FTC vs FA) FTC vs FA Ttest FTC vs FA p < 0.05 hsa-miR-150_st 0.003836 1.0 0.996655 0 hsa-let-7a-2-star_st 0.325804 1.3 0.175696 0 hsa-let-7a-star_st −0.10137 1.1 0.636749 0 hsa-miR-513b_st −1.02885 2.0 0.192564 0 hsa-let-7b-star_st 0.198184 1.1 0.669089 0 hsa-miR-593-star_st −0.44525 1.4 0.463581 0 hsa-let-7c-star_st 0.332362 1.3 0.244083 0 hsa-miR-516a-5p_st −0.3644 1.3 0.410034 0 hsa-miR-142-5p_st 0.536235 1.5 0.517933 0 hsa-miR-650_st 0.259015 1.2 0.241864 0 hsa-miR-513c_st −0.8616 1.8 0.112568 0 hsa-miR-761_st 0.354092 1.3 0.378996 0 hsa-let-7f-1-star_st 0.013547 1.0 0.957907 0 hsa-miR-513a-5p_st −0.51318 1.4 0.33953 0 hsa-miR-654-5p_st −0.47094 1.4 0.2192 0 hsa-let-7g-star_st 0.257717 1.2 0.113322 0 hsa-miR-3163_st −0.22633 1.2 0.501702 0 hsa-let-7i-star_st 0.561389 1.5 0.17176 0 hsa-miR-3165_st −0.50593 1.4 0.393862 0 hsa-miR-3194_st −0.42498 1.3 0.205253 0 hsa-miR-100-star_st −0.27434 1.2 0.257596 0 hsa-miR-4251_st −0.50621 1.4 0.160794 0 hsa-miR-101-star_st 0.221492 1.2 0.207631 0 hsa-miR-922_st −0.12426 1.1 0.715252 0 hsa-miR-103-2-star_st 0.594554 1.5 0.076983 0 hsa-miR-155_st 0.542637 1.5 0.413611 0 hsa-miR-105_st −0.42862 1.3 0.063243 0 hsa-miR-127-5p_st −0.20376 1.2 0.659722 0 hsa-miR-1286_st −0.3218 1.2 0.370843 0 hsa-miR-106a-star_st −0.14304 1.1 0.513652 0 hsa-miR-890_st 0.403576 1.3 0.429766 0 hsa-miR-3126-5p_st −0.49179 1.4 0.280106 0 hsa-miR-489_st −0.48205 1.4 0.313892 0 hsa-miR-10a_st 0.59487 1.5 0.475798 0 hsa-miR-10a-star_st −0.2726 1.2 0.535923 0 hsa-miR-10b_st 1.175412 2.3 0.132391 0 hsa-miR-10b-star_st 0.378516 1.3 0.167565 0 hsa-miR-1178_st −0.14814 1.1 0.55587 0 hsa-miR-1179_st 0.134934 1.1 0.496792 0 hsa-miR-1180_st −0.13361 1.1 0.463428 0 hsa-miR-1181_st −0.2297 1.2 0.425063 0 hsa-miR-3138_st −0.59368 1.5 0.20186 0 hsa-miR-220c_st 0.069334 1.0 0.823321 0 hsa-miR-510_st −0.33613 1.3 0.441986 0 hsa-miR-1185_st −0.15794 1.1 0.450307 0 hsa-miR-1193_st −0.09507 1.1 0.47958 0 hsa-miR-1197_st −0.09755 1.1 0.544511 0 hsa-miR-1200_st −0.18223 1.1 0.271045 0 hsa-miR-1201_st 0.497869 1.4 0.192279 0 hsa-miR-1202_st −0.38505 1.3 0.088086 0 hsa-miR-30c-1-star_st −0.3181 1.2 0.426943 0 hsa-miR-1204_st −0.33967 1.3 0.172337 0 hsa-miR-1205_st −0.05437 1.0 0.773985 0 hsa-miR-1206_st 0.092767 1.1 0.601934 0 hsa-miR-1207-3p_st −0.24224 1.2 0.302448 0 hsa-miR-1207-5p_st −0.12644 1.1 0.30313 0 hsa-miR-1208_st −0.05562 1.0 0.813682 0 hsa-miR-622_st −0.07561 1.1 0.794946 0 hsa-miR-1224-3p_st 0.41131 1.3 0.093099 0 hsa-miR-2116_st −0.26403 1.2 0.41496 0 hsa-miR-1225-3p_st −0.0211 1.0 0.933814 0 hsa-miR-1225-5p_st −0.25403 1.2 0.084018 0 hsa-miR-1226_st −0.04371 1.0 0.886722 0 hsa-miR-30b-star_st −0.24461 1.2 0.497773 0 hsa-miR-1227_st 0.080551 1.1 0.748748 0 hsa-miR-1295_st −0.29175 1.2 0.357567 0 hsa-miR-1228-star_st −0.17726 1.1 0.303704 0 hsa-miR-20b_st 1.393321 2.6 0.007491 1 hsa-miR-122-star_st −0.07082 1.1 0.679438 0 hsa-miR-1231_st −0.14168 1.1 0.384212 0 hsa-miR-1233_st −0.1251 1.1 0.637901 0 hsa-miR-524-5p_st 0.490487 1.4 0.039963 1 hsa-miR-1236_st −0.02625 1.0 0.917008 0 hsa-miR-873_st 0.004392 1.0 0.990347 0 hsa-miR-1238_st −0.13155 1.1 0.610999 0 hsa-miR-124_st −0.03298 1.0 0.919044 0 hsa-miR-1243_st 0.109821 1.1 0.502253 0 hsa-miR-1244_st 0.15787 1.1 0.731159 0 hsa-miR-1245_st −0.35187 1.3 0.06721 0 hsa-miR-3122_st −0.43257 1.3 0.015308 1 hsa-miR-134_st −0.34478 1.3 0.1841 0 hsa-miR-1248_st −0.01262 1.0 0.982584 0 hsa-miR-146a_st 0.076817 1.1 0.906507 0 hsa-miR-124-star_st −0.02231 1.0 0.905552 0 hsa-miR-1250_st −0.30995 1.2 0.203582 0 hsa-miR-764_st −0.14147 1.1 0.68 0 hsa-miR-1252_st −0.09116 1.1 0.634445 0 hsa-miR-223_st 0.707102 1.6 0.33318 0 hsa-miR-34c-3p_st −0.42804 1.3 0.198129 0 hsa-miR-1255a_st 0.354796 1.3 0.29976 0 hsa-miR-1255b_st −0.04498 1.0 0.923466 0 hsa-miR-1256_st −0.25955 1.2 0.153655 0 hsa-miR-1257_st 0.269746 1.2 0.255212 0 hsa-miR-199b-5p_st 0.930589 1.9 0.338894 0 hsa-miR-1259_st −0.17603 1.1 0.349428 0 hsa-miR-492_st −0.28584 1.2 0.287361 0 hsa-miR-3132_st 0.115766 1.1 0.6706 0 hsa-miR-516b_st −0.21045 1.2 0.611988 0 hsa-miR-4294_st −0.47144 1.4 0.24005 0 hsa-miR-125b-2-star_st −0.02654 1.0 0.952393 0 hsa-miR-126_st 0.131316 1.1 0.679531 0 hsa-miR-198_st −0.28898 1.2 0.376912 0 hsa-miR-3191_st −0.21265 1.2 0.57663 0 hsa-miR-1261_st −0.20921 1.2 0.629733 0 hsa-miR-1262_st 0.125836 1.1 0.595311 0 hsa-miR-1263_st 0.035287 1.0 0.874418 0 hsa-miR-1264_st −0.12409 1.1 0.576297 0 hsa-miR-1265_st 0.238907 1.2 0.264928 0 hsa-miR-2114-star_st −0.51922 1.4 0.287403 0 hsa-miR-1267_st −0.12494 1.1 0.445954 0 hsa-miR-1268_st −0.2106 1.2 0.16381 0 hsa-miR-1269_st −0.00917 1.0 0.968741 0 hsa-miR-509-5p_st −0.35736 1.3 0.315176 0 hsa-miR-1270_st −0.10182 1.1 0.710382 0 hsa-miR-1271_st 0.351597 1.3 0.183804 0 hsa-miR-4303_st −0.18228 1.1 0.574812 0 hsa-miR-1273_st −0.27487 1.2 0.399895 0 hsa-miR-583_st 0.37343 1.3 0.264227 0 hsa-miR-1273d_st 0.060487 1.0 0.780517 0 hsa-miR-127-3p_st 0.905185 1.9 0.176428 0 hsa-miR-522-star_st −0.04203 1.0 0.850447 0 hsa-miR-214-star_st 0.380942 1.3 0.473353 0 hsa-miR-184_st −0.15633 1.1 0.679391 0 hsa-miR-614_st −0.14985 1.1 0.7256 0 hsa-miR-526b_st 0.22904 1.2 0.27066 0 hsa-miR-1277_st −0.11746 1.1 0.426858 0 hsa-miR-1278_st 0.152325 1.1 0.430256 0 hsa-miR-1279_st −0.29544 1.2 0.152811 0 hsa-miR-409-3p_st 0.262991 1.2 0.553498 0 hsa-miR-199a-5p_st 0.442479 1.4 0.557219 0 hsa-miR-1281_st −0.40291 1.3 0.142918 0 hsa-miR-1282_st −0.23257 1.2 0.452536 0 hsa-miR-33b-star_st −0.18028 1.1 0.313987 0 hsa-miR-1284_st 0.049141 1.0 0.858039 0 hsa-miR-1253_st 0.025939 1.0 0.913677 0 hsa-miR-584_st −0.4196 1.3 0.182109 0 hsa-miR-1287_st 0.311008 1.2 0.178138 0 hsa-miR-15a_st 1.310073 2.5 0.001717 1 hsa-miR-1289_st −0.04316 1.0 0.877156 0 hsa-miR-1290_st 0.181996 1.1 0.594639 0 hsa-miR-2117_st −0.38672 1.3 0.124999 0 hsa-miR-1292_st −0.38287 1.3 0.080214 0 hsa-miR-1293_st −0.17898 1.1 0.339154 0 hsa-miR-129-3p_st −0.22743 1.2 0.387779 0 hsa-miR-520d-5p_st 0.17157 1.1 0.443027 0 hsa-miR-526a_st 0.1606 1.1 0.513446 0 hsa-miR-129-5p_st −0.11485 1.1 0.548517 0 hsa-miR-1254_st −0.4552 1.4 0.150491 0 hsa-miR-1297_st −0.33044 1.3 0.095622 0 hsa-miR-1298_st −0.00101 1.0 0.997089 0 hsa-miR-1299_st −0.3758 1.3 0.46307 0 hsa-miR-129-star_st −0.03298 1.0 0.899993 0 hsa-miR-1301_st −0.03646 1.0 0.802275 0 hsa-miR-19b_st 1.184416 2.3 0.005216 1 hsa-miR-1303_st 0.157821 1.1 0.452521 0 hsa-miR-1304_st −0.1963 1.1 0.588294 0 hsa-miR-1305_st −0.18201 1.1 0.369098 0 hsa-miR-550_st −0.20556 1.2 0.439316 0 hsa-miR-1307_st −0.12244 1.1 0.531195 0 hsa-miR-1308_st −0.14495 1.1 0.616316 0 hsa-miR-4291_st 0.802479 1.7 0.047259 1 hsa-miR-130a-star_st 0.109584 1.1 0.61411 0 hsa-miR-130b_st 0.465996 1.4 0.197674 0 hsa-miR-130b-star_st 0.394666 1.3 0.190611 0 hsa-miR-921_st −0.40363 1.3 0.222751 0 hsa-miR-520a-5p_st 0.142514 1.1 0.484687 0 hsa-miR-711_st −0.13196 1.1 0.600093 0 hsa-miR-1323_st −0.32687 1.3 0.089014 0 hsa-miR-1324_st −0.22425 1.2 0.375327 0 hsa-miR-490-3p_st 0.023188 1.0 0.910049 0 hsa-miR-718_st −0.3028 1.2 0.257337 0 hsa-miR-133b_st 0.352275 1.3 0.714409 0 hsa-miR-431-star_st −0.03674 1.0 0.848118 0 hsa-miR-552_st −0.3833 1.3 0.272048 0 hsa-miR-28-3p_st 1.112476 2.2 0.039397 1 hsa-miR-4265_st −0.2392 1.2 0.259457 0 hsa-miR-643_st −0.22475 1.2 0.450376 0 hsa-miR-136_st −0.19257 1.1 0.242366 0 hsa-miR-136-star_st −0.28907 1.2 0.106537 0 hsa-miR-137_st −0.2567 1.2 0.098722 0 hsa-miR-138_st −0.67951 1.6 0.274221 0 hsa-miR-138-1-star_st −0.23227 1.2 0.540071 0 hsa-miR-138-2-star_st 0.115334 1.1 0.592604 0 hsa-miR-139-3p_st 0.168319 1.1 0.525832 0 hsa-miR-139-5p_st −0.4915 1.4 0.390058 0 hsa-miR-140-3p_st 0.213999 1.2 0.509873 0 hsa-miR-140-5p_st 0.594881 1.5 0.178993 0 hsa-miR-381_st 0.410303 1.3 0.14224 0 hsa-miR-141-star_st −0.01286 1.0 0.947046 0 hsa-miR-17-star_st 1.069325 2.1 0.001398 1 hsa-miR-4300_st 0.249647 1.2 0.324799 0 hsa-miR-143_st 0.099073 1.1 0.814723 0 hsa-miR-143-star_st 0.064001 1.0 0.886892 0 hsa-miR-144_st −0.03104 1.0 0.873945 0 hsa-miR-3198_st −0.2791 1.2 0.24046 0 hsa-miR-145_st −0.23029 1.2 0.626408 0 hsa-miR-145-star_st 0.338401 1.3 0.578648 0 hsa-miR-1468_st −0.05853 1.0 0.842844 0 hsa-miR-1469_st −0.22001 1.2 0.255943 0 hsa-miR-1973_st −0.98965 2.0 0.035477 1 hsa-miR-3154_st −0.21282 1.2 0.235722 0 hsa-miR-148a-star_st 0.11257 1.1 0.777449 0 hsa-miR-92a-1-star_st −0.09235 1.1 0.501626 0 hsa-miR-147_st −0.24518 1.2 0.259086 0 hsa-miR-194-star_st 0.051873 1.0 0.850738 0 hsa-miR-1471_st −0.60885 1.5 0.059959 0 hsa-miR-147b_st 0.003271 1.0 0.984504 0 hsa-miR-148a_st 0.268362 1.2 0.651317 0 hsa-miR-4299_st −0.63659 1.6 0.26584 0 hsa-miR-135a-star_st −0.50347 1.4 0.047347 1 hsa-miR-612_st −0.24754 1.2 0.299792 0 hsa-miR-1321_st −0.05212 1.0 0.817109 0 hsa-miR-149-star_st −0.24344 1.2 0.12765 0 hsa-miR-604_st −0.70652 1.6 0.115743 0 hsa-miR-150-star_st −0.23793 1.2 0.142551 0 hsa-miR-125b-1-star_st −0.28508 1.2 0.309505 0 hsa-miR-1183_st −0.25275 1.2 0.309972 0 hsa-miR-152_st 0.518116 1.4 0.184197 0 hsa-miR-153_st −0.29271 1.2 0.243131 0 hsa-miR-1537_st −0.01666 1.0 0.932074 0 hsa-miR-1538_st −0.40459 1.3 0.129828 0 hsa-miR-1539_st 0.096235 1.1 0.527217 0 hsa-miR-154_st −0.19224 1.1 0.628882 0 hsa-miR-154-star_st −0.0838 1.1 0.72676 0 hsa-miR-432-star_st 0.154459 1.1 0.568277 0 hsa-miR-155-star_st −0.04258 1.0 0.82719 0 hsa-miR-298_st −0.13708 1.1 0.580294 0 hsa-miR-15a-star_st −0.33585 1.3 0.298625 0 hsa-miR-2110_st −0.21991 1.2 0.525684 0 hsa-miR-15b-star_st −0.04254 1.0 0.843238 0 hsa-miR-1266_st −0.25442 1.2 0.279239 0 hsa-miR-16-1-star_st −0.06886 1.0 0.63305 0 hsa-miR-16-2-star_st −0.12532 1.1 0.695799 0 hsa-miR-490-5p_st −0.20496 1.2 0.434725 0 hsa-miR-19a_st 0.939436 1.9 0.035645 1 hsa-miR-3192_st −0.06433 1.0 0.771187 0 hsa-miR-3155_st −0.11677 1.1 0.615847 0 hsa-miR-187-star_st −0.38009 1.3 0.030786 1 hsa-miR-16_st 0.879417 1.8 0.003576 1 hsa-miR-936_st 0.067135 1.0 0.655372 0 hsa-miR-181c-star_st −0.16313 1.1 0.607546 0 hsa-miR-379_st 0.279999 1.2 0.496459 0 hsa-miR-370_st −0.54476 1.5 0.015404 1 hsa-miR-541_st −0.16408 1.1 0.422944 0 hsa-miR-518c-star_st 0.074397 1.1 0.690127 0 hsa-miR-487b_st 0.878813 1.8 0.039817 1 hsa-miR-182-star_st −0.00021 1.0 0.998904 0 hsa-miR-3121_st −0.4014 1.3 0.418844 0 hsa-miR-3190-5p_st −0.09848 1.1 0.613653 0 hsa-miR-1203_st −0.09492 1.1 0.661261 0 hsa-miR-185_st 0.288917 1.2 0.341366 0 hsa-miR-185-star_st −0.04197 1.0 0.874154 0 hsa-miR-4317_st −0.32789 1.3 0.212118 0 hsa-miR-186-star_st −0.26357 1.2 0.168196 0 hsa-miR-187_st 0.424559 1.3 0.361429 0 hsa-miR-4257_st −0.3684 1.3 0.099727 0 hsa-miR-188-3p_st 0.21871 1.2 0.429532 0 hsa-miR-1184_st −0.08692 1.1 0.694332 0 hsa-miR-18a_st 0.590025 1.5 0.063609 0 hsa-miR-18a-star_st −0.05358 1.0 0.842285 0 hsa-miR-3140_st 0.267417 1.2 0.273013 0 hsa-miR-18b-star_st −0.12582 1.1 0.402835 0 hsa-miR-190_st −0.52568 1.4 0.055844 0 hsa-miR-601_st −0.59045 1.5 0.098543 0 hsa-miR-1909_st −0.01963 1.0 0.912385 0 hsa-miR-342-5p_st 0.58679 1.5 0.207251 0 hsa-miR-575_st −0.46688 1.4 0.163002 0 hsa-miR-885-5p_st 0.217186 1.2 0.570236 0 hsa-miR-300_st 0.1799 1.1 0.447808 0 hsa-miR-1911_st 0.04549 1.0 0.790064 0 hsa-miR-1911-star_st 0.23366 1.2 0.381517 0 hsa-miR-1912_st −0.03857 1.0 0.840783 0 hsa-miR-4266_st 0.234489 1.2 0.331129 0 hsa-miR-1914_st 0.161852 1.1 0.501282 0 hsa-miR-3190-3p_st −0.2421 1.2 0.244911 0 hsa-miR-618_st 0.020008 1.0 0.896828 0 hsa-miR-1276_st −0.00159 1.0 0.995653 0 hsa-miR-191-star_st −0.22441 1.2 0.473402 0 hsa-miR-1258_st −0.12626 1.1 0.594195 0 hsa-miR-192-star_st −0.01681 1.0 0.928652 0 hsa-miR-193a-3p_st 0.318091 1.2 0.5794 0 hsa-miR-193a-5p_st −0.1513 1.1 0.439416 0 hsa-miR-3157_st −0.12115 1.1 0.585992 0 hsa-miR-193b-star_st −0.05019 1.0 0.765973 0 hsa-miR-194_st 1.054228 2.1 0.07215 0 hsa-miR-4307_st 0.162377 1.1 0.559416 0 hsa-miR-195_st 0.315144 1.2 0.482844 0 hsa-miR-610_st 0.102312 1.1 0.736562 0 hsa-miR-196a_st −0.49243 1.4 0.094788 0 hsa-miR-196a-star_st −0.63025 1.5 0.264187 0 hsa-miR-196b_st −0.45355 1.4 0.0835 0 hsa-miR-196b-star_st 0.130945 1.1 0.652363 0 hsa-let-7f-2-star_st 0.234126 1.2 0.146362 0 hsa-miR-1972_st −0.11039 1.1 0.673881 0 hsa-miR-3184_st −0.01737 1.0 0.951014 0 hsa-miR-523-star_st −0.00534 1.0 0.985871 0 hsa-miR-1976_st 0.098332 1.1 0.758766 0 hsa-miR-625-star_st −0.01378 1.0 0.943011 0 hsa-miR-587_st −0.37131 1.3 0.219819 0 hsa-miR-199a-3p_st 0.524178 1.4 0.438371 0 hsa-miR-1910_st −0.03165 1.0 0.825499 0 hsa-miR-199b-3p_st 0.389436 1.3 0.579092 0 hsa-miR-639_st −0.38982 1.3 0.247965 0 hsa-miR-1909-star_st 0.078349 1.1 0.740041 0 hsa-miR-19a-star_st −0.03188 1.0 0.903242 0 hsa-miR-29c-star_st 0.827405 1.8 0.022357 1 hsa-miR-940_st −0.22949 1.2 0.325235 0 hsa-miR-19b-2-star_st 0.053112 1.0 0.789727 0 hsa-miR-4269_st 0.156873 1.1 0.458241 0 hsa-miR-200a-star_st −0.12614 1.1 0.701441 0 hsa-miR-1182_st −0.09861 1.1 0.547573 0 hsa-miR-518f-star_st 0.275252 1.2 0.200814 0 hsa-miR-92a-2-star_st 0.015203 1.0 0.95393 0 hsa-miR-200c-star_st −0.18166 1.1 0.499049 0 hsa-miR-202_st −0.31536 1.2 0.1793 0 hsa-miR-202-star_st −0.21291 1.2 0.331878 0 hsa-miR-1914-star_st −0.33985 1.3 0.197798 0 hsa-miR-204_st −0.63928 1.6 0.576356 0 hsa-miR-665_st 0.094965 1.1 0.633859 0 hsa-miR-2052_st −0.29051 1.2 0.248245 0 hsa-miR-2053_st −0.14261 1.1 0.474388 0 hsa-miR-2054_st −0.33495 1.3 0.267716 0 hsa-miR-205-star_st 0.101211 1.1 0.712732 0 hsa-miR-206_st 0.469757 1.4 0.550088 0 hsa-miR-208a_st −0.16011 1.1 0.53918 0 hsa-miR-208b_st −0.19158 1.1 0.434909 0 hsa-miR-18b_st 0.312286 1.2 0.106268 0 hsa-miR-20a-star_st −0.02928 1.0 0.905583 0 hsa-miR-3181_st −0.39349 1.3 0.09546 0 hsa-miR-615-5p_st −0.1187 1.1 0.683267 0 hsa-miR-4259_st −0.28231 1.2 0.175944 0 hsa-miR-210_st −0.22271 1.2 0.152454 0 hsa-miR-211_st −0.38606 1.3 0.159651 0 hsa-miR-887_st 0.045794 1.0 0.779471 0 hsa-miR-2113_st 0.054839 1.0 0.847355 0 hsa-miR-2114_st 0.22601 1.2 0.400624 0 hsa-miR-943_st −0.33372 1.3 0.28924 0 hsa-miR-2115_st −0.1731 1.1 0.502227 0 hsa-miR-2115-star_st −0.56217 1.5 0.208313 0 hsa-miR-183-star_st −0.16789 1.1 0.464559 0 hsa-miR-2116-star_st −0.09377 1.1 0.74101 0 hsa-miR-920_st −0.08936 1.1 0.712158 0 hsa-miR-212_st 0.555679 1.5 0.050331 0 hsa-miR-214_st 0.318007 1.2 0.258146 0 hsa-miR-1825_st 0.013224 1.0 0.964096 0 hsa-miR-215_st 0.455728 1.4 0.317787 0 hsa-miR-216a_st −0.01247 1.0 0.946598 0 hsa-miR-195-star_st −0.00815 1.0 0.98036 0 hsa-miR-217_st 0.025238 1.0 0.836272 0 hsa-miR-23a-star_st −0.09992 1.1 0.603459 0 hsa-miR-25-star_st −0.06127 1.0 0.747359 0 hsa-miR-218-2-star_st −0.36215 1.3 0.054017 0 hsa-miR-1273c_st −0.2269 1.2 0.284232 0 hsa-miR-219-2-3p_st 0.008697 1.0 0.9686 0 hsa-miR-637_st −0.21539 1.2 0.273647 0 hsa-miR-21-star_st 0.351195 1.3 0.45782 0 hsa-miR-22_st 0.264031 1.2 0.515382 0 hsa-miR-220a_st −0.03039 1.0 0.864642 0 hsa-miR-220b_st 0.22936 1.2 0.121463 0 hsa-miR-219-1-3p_st 0.121044 1.1 0.588524 0 hsa-miR-4316_st −0.0366 1.0 0.863921 0 hsa-miR-877_st −0.35586 1.3 0.093057 0 hsa-miR-636_st −0.31417 1.2 0.226602 0 hsa-miR-3177_st −0.25318 1.2 0.252259 0 hsa-miR-1249_st 0.204442 1.2 0.544919 0 hsa-miR-223-star_st 0.110664 1.1 0.596729 0 hsa-miR-1224-5p_st −0.24767 1.2 0.047312 1 hsa-miR-564_st 0.003984 1.0 0.983171 0 hsa-miR-2276_st −0.28163 1.2 0.325487 0 hsa-miR-2277_st −0.11621 1.1 0.671345 0 hsa-miR-2278_st −0.11692 1.1 0.63711 0 hsa-miR-22-star_st 0.447054 1.4 0.375115 0 hsa-miR-2355_st 0.18533 1.1 0.285112 0 hsa-miR-769-3p_st 0.187209 1.1 0.491316 0 hsa-miR-1913_st 0.097857 1.1 0.680536 0 hsa-miR-1237_st −0.06883 1.0 0.782384 0 hsa-miR-1275_st −0.17946 1.1 0.318034 0 hsa-miR-30a_st 0.702289 1.6 0.033484 1 hsa-miR-20b-star_st −0.1173 1.1 0.711515 0 hsa-miR-24-2-star_st 0.657574 1.6 0.102824 0 hsa-miR-3173_st 0.002413 1.0 0.989499 0 hsa-miR-3148_st −0.01982 1.0 0.939345 0 hsa-miR-4271_st −0.25843 1.2 0.250517 0 hsa-miR-659_st −0.14004 1.1 0.388542 0 hsa-miR-26a-2-star_st 0.004623 1.0 0.985204 0 hsa-miR-1228_st 0.036272 1.0 0.899249 0 hsa-miR-26b-star_st 0.245685 1.2 0.436264 0 hsa-miR-3174_st −0.22583 1.2 0.544189 0 hsa-miR-27a-star_st 0.435443 1.4 0.190579 0 hsa-miR-1285_st −0.05276 1.0 0.774395 0 hsa-miR-483-5p_st −0.09419 1.1 0.534096 0 hsa-miR-1306_st −0.32594 1.3 0.138555 0 hsa-miR-431_st 0.266418 1.2 0.191264 0 hsa-miR-765_st 0.059869 1.0 0.658546 0 hsa-miR-2909_st −0.09086 1.1 0.652788 0 hsa-miR-296-3p_st −0.12957 1.1 0.389583 0 hsa-miR-296-5p_st 0.409785 1.3 0.093498 0 hsa-miR-297_st −0.13227 1.1 0.688193 0 hsa-miR-323b-5p_st −0.00966 1.0 0.973028 0 hsa-miR-299-3p_st −0.0584 1.0 0.855487 0 hsa-miR-299-5p_st 0.199926 1.1 0.71785 0 hsa-miR-487a_st 0.652011 1.6 0.026021 1 hsa-miR-29a-star_st −0.2071 1.2 0.387386 0 hsa-miR-625_st 0.187187 1.1 0.285366 0 hsa-miR-611_st 0.296266 1.2 0.314694 0 hsa-miR-3186-3p_st 0.592138 1.5 0.01845 1 hsa-miR-1294_st −0.15067 1.1 0.483346 0 hsa-miR-3147_st −0.22716 1.2 0.13649 0 hsa-miR-4285_st −0.00397 1.0 0.987958 0 hsa-miR-125a-3p_st −0.13057 1.1 0.470488 0 hsa-miR-301b_st −0.24909 1.2 0.29242 0 hsa-miR-302a_st −0.10563 1.1 0.635504 0 hsa-miR-518e-star_st 0.531879 1.4 0.017386 1 hsa-miR-302b_st −0.43853 1.4 0.062662 0 hsa-miR-302b-star_st −0.41174 1.3 0.082041 0 hsa-miR-302c_st 0.164246 1.1 0.453346 0 hsa-miR-302c-star_st −0.14466 1.1 0.537231 0 hsa-miR-302d_st −0.22345 1.2 0.27114 0 hsa-miR-302d-star_st −0.37844 1.3 0.312963 0 hsa-miR-302e_st −0.10597 1.1 0.659759 0 hsa-miR-302f_st −0.16113 1.1 0.456363 0 hsa-miR-3065-3p_st 0.078631 1.1 0.807272 0 hsa-miR-3130-5p_st −0.43954 1.4 0.129325 0 hsa-miR-3074_st −0.06886 1.0 0.73261 0 hsa-miR-1226-star_st −0.13359 1.1 0.455884 0 hsa-miR-3180-5p_st −0.40507 1.3 0.135352 0 hsa-miR-1229_st 0.489727 1.4 0.018966 1 hsa-miR-1272_st −0.02114 1.0 0.919707 0 hsa-miR-30c_st 0.349158 1.3 0.166232 0 hsa-miR-675_st 0.066196 1.0 0.762315 0 hsa-miR-30c-2-star_st 0.316159 1.2 0.337064 0 hsa-miR-1827_st 0.480675 1.4 0.021877 1 hsa-miR-30d-star_st 0.163308 1.1 0.534749 0 hsa-miR-30e_st 0.771675 1.7 0.066487 0 hsa-miR-1915-star_st 0.318779 1.2 0.258521 0 hsa-miR-1322_st −0.07789 1.1 0.737166 0 hsa-miR-3115_st 0.067627 1.0 0.701797 0 hsa-miR-3116_st 0.06531 1.0 0.870858 0 hsa-miR-3117_st −0.21651 1.2 0.381911 0 hsa-miR-3118_st −0.11587 1.1 0.462349 0 hsa-miR-519b-5p_st 0.470862 1.4 0.026035 1 hsa-miR-3120_st −0.04621 1.0 0.85861 0 hsa-miR-520d-3p_st 0.017927 1.0 0.952501 0 hsa-miR-326_st 0.305541 1.2 0.039498 1 hsa-miR-3123_st −0.22243 1.2 0.379764 0 hsa-miR-3124_st 0.112754 1.1 0.635706 0 hsa-miR-3125_st 0.386197 1.3 0.213787 0 hsa-miR-3126-3p_st −0.22577 1.2 0.338611 0 hsa-miR-1296_st 0.22741 1.2 0.280658 0 hsa-miR-3127_st −0.5043 1.4 0.123788 0 hsa-miR-3128_st −0.26163 1.2 0.204875 0 hsa-miR-3129_st −0.15283 1.1 0.37761 0 hsa-miR-3130-3p_st −0.08429 1.1 0.693096 0 hsa-miR-105-star_st −0.21856 1.2 0.232531 0 hsa-miR-3131_st 0.03666 1.0 0.821258 0 hsa-miR-4255_st −0.00708 1.0 0.966983 0 hsa-miR-3133_st −0.70949 1.6 0.264718 0 hsa-miR-3134_st −0.15734 1.1 0.470192 0 hsa-miR-3135_st 0.133846 1.1 0.570501 0 hsa-miR-3136_st −0.38367 1.3 0.079466 0 hsa-miR-19b-1-star_st 0.299396 1.2 0.040925 1 hsa-miR-1247_st 0.1167 1.1 0.692077 0 hsa-miR-3139_st 0.220996 1.2 0.118611 0 hsa-miR-596_st 0.12537 1.1 0.610588 0 hsa-miR-3141_st −0.09855 1.1 0.543104 0 hsa-miR-3142_st −0.12099 1.1 0.458119 0 hsa-miR-1302_st −0.24041 1.2 0.034153 1 hsa-miR-3144-3p_st 0.099056 1.1 0.565169 0 hsa-miR-3144-5p_st 0.100303 1.1 0.641545 0 hsa-miR-3145_st −0.37099 1.3 0.13191 0 hsa-miR-3146_st −0.23063 1.2 0.375543 0 hsa-miR-346_st −0.44308 1.4 0.024098 1 hsa-miR-4256_st −0.26696 1.2 0.237085 0 hsa-miR-3149_st 0.039324 1.0 0.878595 0 hsa-miR-3150_st −0.06843 1.0 0.737875 0 hsa-miR-3151_st −0.02838 1.0 0.869404 0 hsa-miR-1470_st −0.00233 1.0 0.989822 0 hsa-miR-3153_st −0.1227 1.1 0.601306 0 hsa-miR-514_st −0.19776 1.1 0.137694 0 hsa-miR-3175_st −0.00683 1.0 0.956104 0 hsa-miR-3156_st 0.106037 1.1 0.549654 0 hsa-miR-504_st 0.190037 1.1 0.506183 0 hsa-miR-3158_st −0.02957 1.0 0.932028 0 hsa-miR-3159_st 0.204391 1.2 0.373196 0 hsa-miR-3160_st −0.1329 1.1 0.575784 0 hsa-miR-3161_st 0.127278 1.1 0.616169 0 hsa-miR-3162_st −0.24025 1.2 0.17853 0 hsa-miR-1234_st −0.6025 1.5 0.022837 1 hsa-miR-3164_st −0.21246 1.2 0.520373 0 hsa-miR-516b-star_st 0.045903 1.0 0.834281 0 hsa-miR-3166_st −0.02793 1.0 0.875235 0 hsa-miR-4327_st −0.30244 1.2 0.037494 1 hsa-miR-3168_st 0.098448 1.1 0.66215 0 hsa-miR-3169_st −0.17784 1.1 0.459052 0 hsa-miR-3170_st 0.148266 1.1 0.619156 0 hsa-miR-3171_st −0.25352 1.2 0.108188 0 hsa-miR-3172_st −0.12244 1.1 0.681242 0 hsa-miR-374b-star_st 0.19868 1.1 0.35442 0 hsa-miR-34c-5p_st −0.04682 1.0 0.736121 0 hsa-miR-758_st −0.10962 1.1 0.806436 0 hsa-miR-3176_st 0.083525 1.1 0.661756 0 hsa-miR-606_st −0.00164 1.0 0.992719 0 hsa-miR-3178_st −0.2091 1.2 0.240435 0 hsa-miR-3179_st −0.12311 1.1 0.642513 0 hsa-miR-3180-3p_st −0.0686 1.0 0.738367 0 hsa-miR-597_st 0.083757 1.1 0.605695 0 hsa-miR-148b-star_st 0.270953 1.2 0.191722 0 hsa-miR-3182_st −0.04667 1.0 0.859014 0 hsa-miR-3183_st −0.30176 1.2 0.255994 0 hsa-miR-144-star_st −0.04646 1.0 0.828943 0 hsa-miR-3185_st −0.20421 1.2 0.273575 0 hsa-miR-4270_st −0.32035 1.2 0.029384 1 hsa-miR-3186-5p_st −0.15868 1.1 0.43347 0 hsa-miR-3187_st −0.22844 1.2 0.210621 0 hsa-miR-3188_st −0.26753 1.2 0.098285 0 hsa-miR-3189_st 0.064718 1.0 0.778392 0 hsa-miR-548b-3p_st −0.17401 1.1 0.55048 0 hsa-miR-99a-star_st −0.16142 1.1 0.744987 0 hsa-miR-376a-star_st −0.45596 1.4 0.049213 1 hsa-miR-216b_st 0.225416 1.2 0.168545 0 hsa-miR-3193_st −0.35662 1.3 0.121107 0 hsa-miR-548v_st −0.26297 1.2 0.141894 0 hsa-miR-26a-1-star_st −0.35219 1.3 0.010771 1 hsa-miR-1291_st −0.44601 1.4 0.232503 0 hsa-miR-3197_st −0.41006 1.3 0.084926 0 hsa-miR-629_st 0.531976 1.4 0.049133 1 hsa-miR-3199_st −0.02385 1.0 0.942048 0 hsa-miR-190b_st −0.10866 1.1 0.50915 0 hsa-miR-32_st −0.09266 1.1 0.683079 0 hsa-miR-3200_st 0.25299 1.2 0.468814 0 hsa-miR-3201_st −0.12097 1.1 0.494382 0 hsa-miR-3202_st 0.225244 1.2 0.479236 0 hsa-miR-320a_st 0.201717 1.2 0.243897 0 hsa-miR-4289_st 0.47655 1.4 0.170494 0 hsa-miR-655_st 0.061635 1.0 0.778477 0 hsa-miR-320b_st 0.340159 1.3 0.173287 0 hsa-miR-219-5p_st −0.13209 1.1 0.653346 0 hsa-miR-323-3p_st −0.15399 1.1 0.48953 0 hsa-miR-323-5p_st −0.23974 1.2 0.420136 0 hsa-miR-323b-3p_st −0.01209 1.0 0.942858 0 hsa-miR-103-as_st 0.098202 1.1 0.518448 0 hsa-miR-424-star_st −0.16483 1.1 0.479445 0 hsa-miR-33a-star_st 0.426555 1.3 0.240727 0 hsa-miR-325_st −0.21088 1.2 0.470211 0 hsa-miR-590-3p_st −0.38457 1.3 0.043842 1 hsa-miR-328_st 0.434852 1.4 0.430281 0 hsa-miR-329_st 0.587996 1.5 0.174679 0 hsa-miR-32-star_st −0.08993 1.1 0.667123 0 hsa-miR-330-3p_st 0.39696 1.3 0.207683 0 hsa-miR-330-5p_st −0.13362 1.1 0.603698 0 hsa-miR-146a-star_st −0.05897 1.0 0.771533 0 hsa-miR-331-5p_st 0.166489 1.1 0.51487 0 hsa-miR-3167_st −0.38632 1.3 0.028809 1 hsa-miR-335-star_st −0.3671 1.3 0.271161 0 hsa-miR-337-3p_st −0.22181 1.2 0.457897 0 hsa-miR-337-5p_st 0.334032 1.3 0.050059 0 hsa-miR-421_st 0.940633 1.9 0.00781 1 hsa-miR-338-5p_st 0.391614 1.3 0.180337 0 hsa-miR-339-3p_st 0.008323 1.0 0.96922 0 hsa-miR-548a-5p_st 0.104566 1.1 0.502446 0 hsa-miR-33a_st −0.29315 1.2 0.11412 0 hsa-miR-590-5p_st 0.331661 1.3 0.147544 0 hsa-miR-33b_st −0.07061 1.1 0.620926 0 hsa-miR-616-star_st −0.02601 1.0 0.926597 0 hsa-miR-569_st −0.39691 1.3 0.013607 1 hsa-miR-340-star_st −0.07495 1.1 0.757352 0 hsa-miR-342-3p_st 0.858351 1.8 0.121309 0 hsa-miR-135b-star_st −0.80802 1.8 0.017496 1 hsa-miR-345_st 0.102672 1.1 0.877297 0 hsa-miR-1288_st −0.40285 1.3 0.022154 1 hsa-miR-135a_st −0.55826 1.5 0.012806 1 hsa-miR-34a-star_st 0.213571 1.2 0.698607 0 hsa-miR-34b_st 0.309455 1.2 0.366191 0 hsa-miR-4288_st −0.10001 1.1 0.685432 0 hsa-miR-222-star_st 0.496349 1.4 0.3587 0 hsa-miR-933_st 0.688178 1.6 0.046823 1 hsa-miR-361-3p_st 0.579094 1.5 0.173452 0 hsa-miR-224-star_st 0.438045 1.4 0.224581 0 hsa-miR-362-3p_st 0.546383 1.5 0.19979 0 hsa-miR-362-5p_st 0.714619 1.6 0.100695 0 hsa-miR-363_st 1.016977 2.0 0.141305 0 hsa-miR-363-star_st 0.035825 1.0 0.8785 0 hsa-miR-1979_st −0.04916 1.0 0.816015 0 hsa-miR-365-star_st −0.12101 1.1 0.471102 0 hsa-miR-548x_st −0.41819 1.3 0.0259 1 hsa-miR-367-star_st 0.035199 1.0 0.865461 0 hsa-miR-369-3p_st −0.20494 1.2 0.37928 0 hsa-miR-369-5p_st 0.392598 1.3 0.311119 0 hsa-miR-548l_st −0.41882 1.3 0.027411 1 hsa-miR-371-3p_st −0.18771 1.1 0.241609 0 hsa-miR-371-5p_st −0.2094 1.2 0.144608 0 hsa-miR-372_st −0.02567 1.0 0.905443 0 hsa-miR-373_st 0.146916 1.1 0.570795 0 hsa-miR-373-star_st −0.04614 1.0 0.80902 0 hsa-miR-374a_st 0.530081 1.4 0.405606 0 hsa-miR-374a-star_st 0.340761 1.3 0.08856 0 hsa-miR-500_st 0.121881 1.1 0.771509 0 hsa-miR-320c_st 0.490756 1.4 0.082508 0 hsa-miR-875-3p_st −0.41951 1.3 0.002608 1 hsa-miR-376a_st 0.390638 1.3 0.377488 0 hsa-miR-29b-1-star_st 1.182829 2.3 0.003987 1 hsa-miR-376b_st 0.224039 1.2 0.518173 0 hsa-miR-376c_st 0.482687 1.4 0.447971 0 hsa-miR-377_st −0.20184 1.2 0.572739 0 hsa-miR-377-star_st −0.05553 1.0 0.862219 0 hsa-miR-378_st 0.034874 1.0 0.954931 0 hsa-miR-378b_st 0.003396 1.0 0.984449 0 hsa-miR-378c_st 0.45578 1.4 0.291792 0 hsa-miR-378-star_st 0.764584 1.7 0.077335 0 hsa-miR-662_st 0.253522 1.2 0.340426 0 hsa-miR-379-star_st −0.04509 1.0 0.819968 0 hsa-miR-380_st −0.16262 1.1 0.390033 0 hsa-miR-380-star_st 0.130985 1.1 0.385396 0 hsa-miR-1274b_st 0.188432 1.1 0.454347 0 hsa-miR-382_st −0.05523 1.0 0.912865 0 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0.164478 1.1 0.422277 0 hsa-miR-4260_st −0.22976 1.2 0.244278 0 hsa-miR-4261_st −0.25639 1.2 0.213052 0 hsa-miR-4262_st −0.35016 1.3 0.074157 0 hsa-miR-4263_st −0.17105 1.1 0.376312 0 hsa-miR-4264_st −0.29874 1.2 0.14594 0 hsa-miR-1280_st −0.07122 1.1 0.75145 0 hsa-miR-132-star_st 0.644864 1.6 0.317217 0 hsa-miR-4267_st −0.10687 1.1 0.69977 0 hsa-miR-4268_st −0.39414 1.3 0.08207 0 hsa-miR-133a_st 0.251796 1.2 0.789324 0 hsa-miR-888-star_st −0.44154 1.4 0.01369 1 hsa-miR-1260b_st −0.04105 1.0 0.848776 0 hsa-miR-4272_st −0.12439 1.1 0.495421 0 hsa-miR-4273_st −0.3116 1.2 0.118686 0 hsa-miR-4274_st −0.10821 1.1 0.687956 0 hsa-miR-4275_st 0.121695 1.1 0.575715 0 hsa-miR-4276_st 0.187941 1.1 0.367846 0 hsa-miR-4277_st −0.12748 1.1 0.475914 0 hsa-miR-4278_st −0.14787 1.1 0.646857 0 hsa-miR-4279_st 0.18407 1.1 0.495189 0 hsa-miR-4280_st −0.03567 1.0 0.889687 0 hsa-miR-4281_st −0.26993 1.2 0.106036 0 hsa-miR-4282_st −0.15489 1.1 0.288005 0 hsa-miR-4283_st −0.09179 1.1 0.686956 0 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0.152162 0 hsa-miR-4308_st 0.254862 1.2 0.350885 0 hsa-miR-4309_st −0.05858 1.0 0.679624 0 hsa-miR-186_st 0.883374 1.8 0.151643 0 hsa-miR-4310_st −0.37783 1.3 0.372101 0 hsa-miR-4311_st 0.185968 1.1 0.482475 0 hsa-miR-4312_st −0.23517 1.2 0.482239 0 hsa-miR-4313_st −0.18373 1.1 0.507883 0 hsa-miR-4314_st −0.236 1.2 0.559123 0 hsa-miR-4315_st −0.10869 1.1 0.659939 0 hsa-miR-149_st 0.797217 1.7 0.106709 0 hsa-miR-106b-star_st 0.683908 1.6 0.068681 0 hsa-miR-4318_st −0.2426 1.2 0.094989 0 hsa-miR-4319_st 0.07725 1.1 0.843461 0 hsa-miR-29b-2-star_st 0.794779 1.7 0.003481 1 hsa-miR-432_st −0.14829 1.1 0.630156 0 hsa-miR-4320_st 0.117533 1.1 0.476177 0 hsa-miR-522_st −0.44901 1.4 0.011901 1 hsa-miR-4322_st −0.21066 1.2 0.184247 0 hsa-miR-4323_st 0.237976 1.2 0.27361 0 hsa-miR-93-star_st 0.652552 1.6 0.021115 1 hsa-miR-4325_st 0.08902 1.1 0.633461 0 hsa-miR-4326_st −0.13236 1.1 0.593053 0 hsa-miR-874_st −0.4532 1.4 0.044163 1 hsa-miR-4328_st −0.01423 1.0 0.938238 0 hsa-let-7e-star_st 0.52421 1.4 0.09974 0 hsa-miR-720_st −0.17549 1.1 0.398842 0 hsa-miR-433_st 0.153648 1.1 0.486532 0 hsa-miR-4330_st −0.60192 1.5 0.148637 0 hsa-miR-448_st −0.19046 1.1 0.243633 0 hsa-miR-449a_st 0.434295 1.4 0.138637 0 hsa-miR-449b_st −0.07026 1.0 0.76864 0 hsa-miR-1975_st −0.13992 1.1 0.501689 0 hsa-miR-449c_st −0.17983 1.1 0.583641 0 hsa-miR-449c-star_st −0.36638 1.3 0.143785 0 hsa-miR-1_st 0.596177 1.5 0.487841 0 hsa-miR-450b-3p_st −0.33638 1.3 0.168266 0 hsa-miR-450b-5p_st −0.31067 1.2 0.187935 0 hsa-miR-451_st 0.285634 1.2 0.627182 0 hsa-miR-452_st 0.451704 1.4 0.119076 0 hsa-miR-452-star_st −0.20887 1.2 0.183201 0 hsa-miR-548b-5p_st −0.48084 1.4 0.027293 1 hsa-miR-454-star_st 0.071639 1.1 0.772005 0 hsa-miR-455-3p_st 0.818152 1.8 0.129233 0 hsa-miR-455-5p_st 0.804104 1.7 0.124627 0 hsa-miR-466_st −0.04361 1.0 0.902311 0 hsa-miR-483-3p_st 0.047001 1.0 0.866173 0 hsa-miR-17_st 0.944249 1.9 0.034817 1 hsa-miR-320d_st 0.617733 1.5 0.099858 0 hsa-miR-485-3p_st 0.526894 1.4 0.147191 0 hsa-miR-485-5p_st 0.027605 1.0 0.900616 0 hsa-miR-486-3p_st 0.235261 1.2 0.425971 0 hsa-miR-486-5p_st −0.0171 1.0 0.979164 0 hsa-miR-644_st −0.48367 1.4 0.025974 1 hsa-miR-3152_st −0.49086 1.4 0.045215 1 hsa-miR-488_st −0.13166 1.1 0.510634 0 hsa-miR-488-star_st 0.019082 1.0 0.917241 0 hsa-miR-450a_st 0.750878 1.7 0.114019 0 hsa-miR-20a_st 1.467805 2.8 0.016524 1 hsa-miR-484_st 0.727815 1.7 0.105457 0 hsa-miR-491-3p_st −0.16755 1.1 0.468417 0 hsa-miR-491-5p_st −0.1459 1.1 0.597685 0 hsa-miR-197_st 0.203223 1.2 0.680364 0 hsa-miR-493_st 0.298667 1.2 0.236587 0 hsa-miR-493-star_st 0.478876 1.4 0.319548 0 hsa-miR-494_st −0.7216 1.6 0.05317 0 hsa-miR-495_st 0.719482 1.6 0.132115 0 hsa-miR-496_st −0.07983 1.1 0.622371 0 hsa-miR-497_st 0.159157 1.1 0.780012 0 hsa-miR-497-star_st −0.14108 1.1 0.286301 0 hsa-miR-498_st −0.07865 1.1 0.703613 0 hsa-miR-499-3p_st −0.0638 1.0 0.649944 0 hsa-miR-24-1-star_st 0.347361 1.3 0.384935 0 hsa-miR-340_st 1.481217 2.8 0.018919 1 hsa-miR-500b_st 0.387867 1.3 0.107183 0 hsa-miR-500-star_st 0.009939 1.0 0.954161 0 hsa-miR-501-3p_st −0.16712 1.1 0.298834 0 hsa-miR-501-5p_st −0.08768 1.1 0.756055 0 hsa-miR-502-3p_st 0.081153 1.1 0.64498 0 hsa-miR-502-5p_st −0.0222 1.0 0.916025 0 hsa-miR-503_st 0.15054 1.1 0.592808 0 hsa-miR-192_st 1.181281 2.3 0.073623 0 hsa-let-7g_st 0.50496 1.4 0.057548 0 hsa-miR-505-star_st 0.151465 1.1 0.488093 0 hsa-miR-506_st −0.27763 1.2 0.185458 0 hsa-miR-507_st 0.01962 1.0 0.935377 0 hsa-miR-508-3p_st −0.33804 1.3 0.130665 0 hsa-miR-508-5p_st 0.088618 1.1 0.668303 0 hsa-miR-509-3-5p_st −0.15098 1.1 0.721564 0 hsa-miR-509-3p_st −0.20814 1.2 0.424985 0 hsa-miR-106a_st 1.047486 2.1 0.025948 1 hsa-miR-106b_st 1.050508 2.1 0.022161 1 hsa-miR-511_st −0.0345 1.0 0.858261 0 hsa-miR-512-3p_st −0.2403 1.2 0.206756 0 hsa-miR-512-5p_st 0.26185 1.2 0.224538 0 hsa-miR-513a-3p_st −0.1855 1.1 0.403998 0 hsa-miR-23a_st 0.384983 1.3 0.221879 0 hsa-miR-25_st 0.917307 1.9 0.039209 1 hsa-miR-598_st 0.816706 1.8 0.080616 0 hsa-miR-1260_st 0.259003 1.2 0.371633 0 hsa-miR-514b-3p_st 0.072381 1.1 0.78519 0 hsa-miR-514b-5p_st 0.037278 1.0 0.825672 0 hsa-miR-515-3p_st −0.49193 1.4 0.041601 1 hsa-miR-515-5p_st −0.13187 1.1 0.448548 0 hsa-miR-516a-3p_st −0.2482 1.2 0.249938 0 hsa-miR-27a_st 0.687725 1.6 0.069102 0 hsa-miR-100_st 0.445035 1.4 0.331952 0 hsa-miR-101_st 1.170239 2.3 0.064749 0 hsa-miR-517a_st 0.258194 1.2 0.338358 0 hsa-miR-517b_st 0.00792 1.0 0.969539 0 hsa-miR-517c_st −0.24007 1.2 0.23638 0 hsa-miR-517-star_st 0.093904 1.1 0.688365 0 hsa-miR-518a-3p_st −0.17195 1.1 0.416557 0 hsa-miR-518a-5p_st −0.08273 1.1 0.77997 0 hsa-miR-518b_st −0.01691 1.0 0.952896 0 hsa-miR-518c_st −0.18337 1.1 0.329533 0 hsa-miR-301a_st 0.62109 1.5 0.091859 0 hsa-miR-518d-3p_st −0.12201 1.1 0.377787 0 hsa-miR-518d-5p_st 0.412508 1.3 0.058226 0 hsa-miR-518e_st −0.12906 1.1 0.470771 0 hsa-let-7f_st 0.385299 1.3 0.17797 0 hsa-miR-518f_st −0.15768 1.1 0.496288 0 hsa-miR-1826_st −0.28317 1.2 0.146806 0 hsa-miR-519a_st −0.3519 1.3 0.101156 0 hsa-miR-519a-star_st 0.205646 1.2 0.53008 0 hsa-miR-519b-3p_st −0.11703 1.1 0.618565 0 hsa-miR-1283_st −0.50359 1.4 0.004887 1 hsa-miR-519c-3p_st −0.36385 1.3 0.214256 0 hsa-miR-519c-5p_st 0.423196 1.3 0.133279 0 hsa-miR-519d_st −0.11132 1.1 0.446168 0 hsa-miR-519e_st −0.06322 1.0 0.78082 0 hsa-miR-519e-star_st −0.1214 1.1 0.46648 0 hsa-miR-520a-3p_st −0.0719 1.1 0.736346 0 hsa-miR-1908_st −0.20244 1.2 0.319725 0 hsa-miR-520b_st −0.08424 1.1 0.535892 0 hsa-miR-520c-3p_st 0.097327 1.1 0.626761 0 hsa-miR-520c-5p_st 0.214178 1.2 0.418918 0 hsa-miR-181a-star_st 0.586007 1.5 0.302362 0 hsa-miR-21_st 1.198378 2.3 0.073527 0 hsa-miR-520e_st −0.10278 1.1 0.642525 0 hsa-miR-520f_st 0.044265 1.0 0.845596 0 hsa-miR-520g_st −0.10602 1.1 0.684439 0 hsa-miR-520h_st 0.025191 1.0 0.872632 0 hsa-miR-521_st 0.135951 1.1 0.502529 0 hsa-miR-302a-star_st −0.51222 1.4 0.006825 1 hsa-miR-886-3p_st 0.757294 1.7 0.29616 0 hsa-miR-523_st −0.34897 1.3 0.127032 0 hsa-miR-29a_st 0.823801 1.8 0.027574 1 hsa-miR-524-3p_st −0.27697 1.2 0.056472 0 hsa-miR-142-3p_st −0.52651 1.4 0.002399 1 hsa-miR-525-3p_st −0.28289 1.2 0.20054 0 hsa-miR-525-5p_st 0.17017 1.1 0.507998 0 hsa-miR-762_st −0.22629 1.2 0.242063 0 hsa-miR-423-3p_st 0.594292 1.5 0.07215 0 hsa-miR-449b-star_st −0.53167 1.4 0.042588 1 hsa-miR-527_st −0.12407 1.1 0.677438 0 hsa-miR-532-3p_st 0.390028 1.3 0.325691 0 hsa-miR-532-5p_st 0.610915 1.5 0.129647 0 hsa-miR-539_st 0.237372 1.2 0.463201 0 hsa-let-7a_st 0.343599 1.3 0.160188 0 hsa-miR-541-star_st −0.22761 1.2 0.272677 0 hsa-miR-542-3p_st 0.085349 1.1 0.870538 0 hsa-miR-542-5p_st 0.318022 1.2 0.182103 0 hsa-miR-543_st 0.191655 1.1 0.575531 0 hsa-miR-544_st −0.18364 1.1 0.421129 0 hsa-miR-544b_st −0.18391 1.1 0.128518 0 hsa-miR-545_st −0.14921 1.1 0.511037 0 hsa-miR-545-star_st −0.10484 1.1 0.692111 0 hsa-miR-548a-3p_st −0.39676 1.3 0.138246 0 hsa-miR-2861_st −0.25298 1.2 0.201364 0 hsa-miR-31_st 0.823581 1.8 0.508736 0 hsa-miR-367_st −0.54016 1.5 0.039111 1 hsa-miR-548c-3p_st −0.228 1.2 0.435425 0 hsa-miR-548c-5p_st 0.192035 1.1 0.59889 0 hsa-miR-548d-3p_st −0.16537 1.1 0.354977 0 hsa-miR-548d-5p_st 0.07192 1.1 0.813325 0 hsa-miR-548e_st −0.11672 1.1 0.580217 0 hsa-miR-548f_st −0.10965 1.1 0.572805 0 hsa-miR-548g_st −0.20237 1.2 0.368203 0 hsa-miR-548h_st 0.316813 1.2 0.140388 0 hsa-miR-548i_st −0.24672 1.2 0.265634 0 hsa-miR-548j_st 0.040691 1.0 0.867893 0 hsa-miR-548k_st −0.07721 1.1 0.601183 0 hsa-miR-526b-star_st −0.54318 1.5 0.022687 1 hsa-miR-548m_st −0.02982 1.0 0.871167 0 hsa-miR-548n_st 0.039972 1.0 0.802876 0 hsa-miR-548o_st −0.24685 1.2 0.259895 0 hsa-miR-548p_st −0.16997 1.1 0.439908 0 hsa-miR-548q_st −0.25939 1.2 0.361052 0 hsa-miR-548s_st −0.19154 1.1 0.265269 0 hsa-miR-548t_st −0.31938 1.2 0.077064 0 hsa-miR-548u_st −0.04713 1.0 0.846127 0 hsa-miR-638_st −0.22643 1.2 0.284057 0 hsa-miR-548w_st 0.009834 1.0 0.979476 0 hsa-miR-3119_st −0.54399 1.5 0.029221 1 hsa-miR-549_st −0.29245 1.2 0.107155 0 hsa-miR-205_st −0.21745 1.2 0.85965 0 hsa-miR-550-star_st 0.549901 1.5 0.169503 0 hsa-miR-551a_st −0.35712 1.3 0.109667 0 hsa-miR-93_st 0.858992 1.8 0.030281 1 hsa-miR-551b-star_st 0.080113 1.1 0.715935 0 hsa-let-7d-star_st 0.262997 1.2 0.622517 0 hsa-miR-553_st 0.013205 1.0 0.944811 0 hsa-miR-554_st −0.10433 1.1 0.489795 0 hsa-miR-555_st −0.23948 1.2 0.23392 0 hsa-miR-556-3p_st −0.47354 1.4 0.056689 0 hsa-miR-556-5p_st −0.23992 1.2 0.172875 0 hsa-miR-557_st −0.16363 1.1 0.433601 0 hsa-miR-558_st −0.00478 1.0 0.979717 0 hsa-miR-559_st −0.15186 1.1 0.430198 0 hsa-miR-561_st 0.006506 1.0 0.974951 0 hsa-miR-562_st −0.21571 1.2 0.270021 0 hsa-miR-563_st −0.05815 1.0 0.80039 0 hsa-miR-361-5p_st 0.613429 1.5 0.08676 0 hsa-miR-566_st 0.046614 1.0 0.85342 0 hsa-miR-567_st −0.37537 1.3 0.210484 0 hsa-miR-568_st −0.21699 1.2 0.201307 0 hsa-miR-29c_st 0.871742 1.8 0.028813 1 hsa-miR-570_st −0.22875 1.2 0.116054 0 hsa-miR-571_st −0.26328 1.2 0.235531 0 hsa-miR-572_st −0.27599 1.2 0.130789 0 hsa-miR-573_st −0.21549 1.2 0.220353 0 hsa-miR-132_st 1.012765 2.0 0.11538 0 hsa-miR-574-5p_st 0.180112 1.1 0.38363 0 hsa-let-7d_st 0.390202 1.3 0.154499 0 hsa-miR-576-3p_st 0.072176 1.1 0.740656 0 hsa-miR-576-5p_st 0.022737 1.0 0.931348 0 hsa-miR-577_st −0.21436 1.2 0.32068 0 hsa-miR-578_st −0.28767 1.2 0.144755 0 hsa-miR-579_st −0.28676 1.2 0.054905 0 hsa-miR-580_st −0.22823 1.2 0.245572 0 hsa-miR-191_st 0.611596 1.5 0.100576 0 hsa-miR-582-3p_st −0.29882 1.2 0.173995 0 hsa-miR-582-5p_st −0.13183 1.1 0.739206 0 hsa-miR-1915_st −0.23195 1.2 0.277909 0 hsa-let-7c_st 0.41704 1.3 0.147112 0 hsa-miR-585_st −0.05815 1.0 0.756127 0 hsa-miR-586_st −0.20801 1.2 0.330797 0 hsa-miR-324-5p_st 0.911369 1.9 0.07229 0 hsa-miR-588_st −0.00721 1.0 0.972887 0 hsa-miR-589_st 0.261368 1.2 0.290756 0 hsa-miR-589-star_st −0.04948 1.0 0.827294 0 hsa-miR-188-5p_st −0.57728 1.5 0.029955 1 hsa-miR-103_st 0.736177 1.7 0.045179 1 hsa-miR-591_st −0.09858 1.1 0.637415 0 hsa-miR-592_st 0.201385 1.1 0.433659 0 hsa-miR-593_st −0.29518 1.2 0.252382 0 hsa-miR-23b_st 0.498592 1.4 0.088324 0 hsa-miR-595_st −0.26424 1.2 0.132634 0 hsa-miR-99a_st 0.267713 1.2 0.588923 0 hsa-miR-15b_st 0.88722 1.8 0.09237 0 hsa-miR-135b_st 0.067593 1.0 0.890162 0 hsa-miR-599_st −0.18698 1.1 0.444202 0 hsa-miR-600_st −0.20556 1.2 0.580542 0 hsa-miR-107_st 0.69593 1.6 0.041501 1 hsa-miR-602_st −0.03475 1.0 0.844066 0 hsa-miR-603_st −0.1608 1.1 0.284283 0 hsa-miR-3065-5p_st 0.144608 1.1 0.792882 0 hsa-miR-605_st −0.39692 1.3 0.184109 0 hsa-miR-24_st 0.697423 1.6 0.044964 1 hsa-miR-607_st −0.05247 1.0 0.736567 0 hsa-miR-608_st −0.10417 1.1 0.604513 0 hsa-miR-609_st 0.186243 1.1 0.343471 0 hsa-miR-3196_st −0.23185 1.2 0.279359 0 hsa-miR-26b_st 0.899369 1.9 0.052113 0 hsa-miR-28-5p_st 0.720874 1.6 0.018164 1 hsa-miR-613_st −0.14196 1.1 0.478472 0 hsa-miR-338-3p_st 0.935617 1.9 0.127168 0 hsa-miR-615-3p_st −0.08947 1.1 0.725218 0 hsa-miR-454_st 1.45012 2.7 0.012139 1 hsa-miR-616_st 0.364132 1.3 0.119188 0 hsa-miR-151-5p_st 0.644212 1.6 0.028287 1 hsa-miR-617_st −0.173 1.1 0.675479 0 hsa-miR-128_st 1.48222 2.8 0.004492 1 hsa-miR-619_st −0.1761 1.1 0.272833 0 hsa-miR-620_st −0.31701 1.2 0.179873 0 hsa-miR-621_st 0.060822 1.0 0.753572 0 hsa-let-7b_st 0.496653 1.4 0.228383 0 hsa-miR-623_st −0.13342 1.1 0.289272 0 hsa-miR-624_st −0.24918 1.2 0.080305 0 hsa-miR-624-star_st −0.04709 1.0 0.865835 0 hsa-miR-183_st 0.749486 1.7 0.209996 0 hsa-miR-30b_st 0.635057 1.6 0.030704 1 hsa-miR-626_st −0.30024 1.2 0.084686 0 hsa-miR-627_st −0.27185 1.2 0.166404 0 hsa-miR-628-3p_st −0.45608 1.4 0.352013 0 hsa-miR-31-star_st 0.556685 1.5 0.627062 0 hsa-miR-218-1-star_st −0.57755 1.5 0.02377 1 hsa-miR-629-star_st 0.608438 1.5 0.054473 0 hsa-miR-630_st −0.43884 1.4 0.220528 0 hsa-miR-631_st −0.3752 1.3 0.337392 0 hsa-miR-632_st −0.35562 1.3 0.197197 0 hsa-miR-633_st −0.27032 1.2 0.130635 0 hsa-miR-634_st −0.45522 1.4 0.376858 0 hsa-miR-635_st −0.27473 1.2 0.285299 0 hsa-miR-203_st 0.694715 1.6 0.473822 0 hsa-miR-331-3p_st 0.274415 1.2 0.379522 0 hsa-miR-125b_st 0.344383 1.3 0.18163 0 hsa-let-7i_st 0.231105 1.2 0.534606 0 hsa-miR-640_st −0.0665 1.0 0.754923 0 hsa-miR-641_st 0.155287 1.1 0.561397 0 hsa-miR-642_st −0.15477 1.1 0.348065 0 hsa-miR-29b_st 1.07442 2.1 0.035492 1 hsa-miR-122_st −0.58419 1.5 0.019978 1 hsa-miR-645_st 0.148649 1.1 0.342359 0 hsa-miR-646_st 0.116662 1.1 0.57264 0 hsa-miR-647_st −0.27979 1.2 0.185186 0 hsa-miR-648_st −0.22064 1.2 0.223533 0 hsa-miR-649_st −0.05432 1.0 0.844278 0 hsa-miR-182_st 0.976855 2.0 0.080887 0 hsa-miR-651_st −0.27723 1.2 0.134973 0 hsa-miR-652_st 0.13121 1.1 0.676776 0 hsa-miR-653_st −0.24667 1.2 0.2497 0 hsa-miR-654-3p_st 0.363983 1.3 0.539926 0 hsa-miR-374b_st 1.127673 2.2 0.066007 0 hsa-miR-130a_st 1.332063 2.5 0.002319 1 hsa-miR-656_st −0.36889 1.3 0.099742 0 hsa-miR-657_st −0.01674 1.0 0.933805 0 hsa-miR-658_st 0.139531 1.1 0.528627 0 hsa-miR-99b_st 0.678469 1.6 0.063338 0 hsa-miR-660_st 0.941285 1.9 0.109644 0 hsa-miR-661_st −0.41538 1.3 0.064604 0 hsa-miR-30e-star_st 0.69883 1.6 0.172264 0 hsa-miR-663_st −0.20328 1.2 0.251363 0 hsa-miR-663b_st −0.23182 1.2 0.29588 0 hsa-miR-664_st 0.045638 1.0 0.912427 0 hsa-miR-664-star_st −0.47706 1.4 0.139167 0 hsa-miR-30d_st 0.558599 1.5 0.037068 1 hsa-miR-668_st 0.221637 1.2 0.39578 0 hsa-miR-670_st −0.27934 1.2 0.255478 0 hsa-miR-671-3p_st 0.419363 1.3 0.14201 0 hsa-miR-671-5p_st −0.17283 1.1 0.308152 0 hsa-miR-30a-star_st 0.845819 1.8 0.109974 0 hsa-miR-675-star_st 0.192926 1.1 0.454078 0 hsa-miR-148b_st 0.542358 1.5 0.15977 0 hsa-miR-708_st 0.022573 1.0 0.976157 0 hsa-miR-708-star_st −0.20003 1.1 0.389326 0 hsa-miR-221-star_st 0.644389 1.6 0.443095 0 hsa-let-7e_st 0.602002 1.5 0.079492 0 hsa-miR-7-1-star_st 0.818186 1.8 0.090888 0 hsa-miR-27b_st 0.760861 1.7 0.050089 0 hsa-miR-34a_st 0.383241 1.3 0.56035 0 hsa-miR-744_st −0.22482 1.2 0.281118 0 hsa-miR-744-star_st 0.000885 1.0 0.997387 0 hsa-miR-92b_st 0.969394 2.0 0.100133 0 hsa-miR-759_st 0.047893 1.0 0.80925 0 hsa-miR-760_st −0.032 1.0 0.878359 0 hsa-miR-92a_st 0.958113 1.9 0.050394 0 hsa-miR-335_st 1.148293 2.2 0.049604 1 hsa-miR-96_st 1.370267 2.6 0.030038 1 hsa-miR-95_st 0.75024 1.7 0.191291 0 hsa-miR-766_st 0.094881 1.1 0.619106 0 hsa-miR-767-3p_st −0.15334 1.1 0.435771 0 hsa-miR-767-5p_st 0.074607 1.1 0.698643 0 hsa-miR-98_st 0.793304 1.7 0.086422 0 hsa-miR-769-5p_st 0.404622 1.3 0.274484 0 hsa-miR-770-5p_st 0.252234 1.2 0.327362 0 hsa-miR-802_st −0.25723 1.2 0.226403 0 hsa-miR-34b-star_st 0.667378 1.6 0.222506 0 hsa-miR-581_st −0.5927 1.5 0.043457 1 hsa-miR-181d_st 0.726291 1.7 0.05447 0 hsa-miR-875-5p_st −0.08774 1.1 0.713419 0 hsa-miR-876-3p_st −0.01905 1.0 0.922733 0 hsa-miR-876-5p_st −0.35423 1.3 0.104072 0 hsa-miR-151-3p_st 0.967325 2.0 0.004102 1 hsa-miR-877-star_st −0.24862 1.2 0.411266 0 hsa-miR-885-3p_st −0.01471 1.0 0.950795 0 hsa-miR-200c_st 0.351142 1.3 0.162451 0 hsa-miR-429_st 0.614115 1.5 0.431716 0 hsa-miR-886-5p_st 0.28086 1.2 0.449666 0 hsa-miR-224_st 1.227236 2.3 0.0576 0 hsa-miR-888_st −0.01071 1.0 0.960366 0 hsa-miR-4321_st −0.6052 1.5 0.030217 1 hsa-miR-889_st −0.23227 1.2 0.224312 0 hsa-miR-181b_st 0.829098 1.8 0.038702 1 hsa-miR-891a_st 0.052375 1.0 0.871011 0 hsa-miR-891b_st −0.06124 1.0 0.758825 0 hsa-miR-892a_st −0.29058 1.2 0.402913 0 hsa-miR-892b_st −0.0824 1.1 0.72864 0 hsa-miR-9_st −0.10667 1.1 0.531681 0 hsa-miR-222_st 0.856482 1.8 0.356972 0 hsa-miR-141_st 1.025937 2.0 0.03662 1 hsa-miR-221_st 0.75331 1.7 0.391953 0 hsa-miR-924_st −0.05225 1.0 0.699682 0 hsa-miR-181a_st 0.660999 1.6 0.199088 0 hsa-miR-181c_st 0.693852 1.6 0.214097 0 hsa-miR-4324_st 0.694992 1.6 0.153322 0 hsa-miR-125a-5p_st 0.613669 1.5 0.147431 0 hsa-miR-92b-star_st −0.15828 1.1 0.338215 0 hsa-miR-3195_st −0.62112 1.5 0.030017 1 hsa-miR-3137_st −0.67262 1.6 0.012909 1 hsa-miR-934_st −0.12305 1.1 0.606649 0 hsa-miR-935_st 0.061615 1.0 0.824991 0 hsa-miR-551b_st 0.829046 1.8 0.377235 0 hsa-miR-937_st −0.24289 1.2 0.445653 0 hsa-miR-938_st −0.04506 1.0 0.828648 0 hsa-miR-939_st −0.19957 1.1 0.198377 0 hsa-miR-7-2-star_st −0.95235 1.9 0.246207 0 hsa-miR-146b-5p_st 2.170586 4.5 0.035006 1 hsa-miR-941_st 0.024869 1.0 0.905811 0 hsa-miR-942_st −0.20163 1.1 0.336643 0 hsa-miR-200a_st 0.39401 1.3 0.696049 0 hsa-miR-944_st −0.1237 1.1 0.599987 0 hsa-miR-7_st −1.71247 3.3 0.24874 0 hsa-miR-375_st 0.857487 1.8 0.046519 1 hsa-miR-96-star_st 0.083458 1.1 0.719748 0 hsa-miR-424_st 0.955879 1.9 0.151543 0 hsa-miR-181a-2-star_st 1.717123 3.3 0.003546 1 hsa-miR-200b_st 0.202495 1.2 0.83073 0 hsa-miR-146b-3p_st 0.976691 2.0 0.181724 0 hsa-miR-99b-star_st −0.01575 1.0 0.943836 0 hsa-miR-9-star_st 0.025966 1.0 0.930189 0 Fold change Log2Diff (Hash (Hash vs Ttest (Hash vs Sample Name vs Benign) Benign) Benign) p < 0.05 hsa-miR-150_st 2.203453771 4.6 0.008364 1 hsa-let-7a-2-star_st 0.011609636 1.0 0.74618 0 hsa-let-7a-star_st −0.231021394 1.2 0.489092 0 hsa-miR-513b_st 0.692991032 1.6 0.10349 0 hsa-let-7b-star_st −0.113920071 1.1 0.521436 0 hsa-miR-593-star_st 0.666203761 1.6 0.111667 0 hsa-let-7c-star_st 0.224440211 1.2 0.083203 0 hsa-miR-516a-5p_st 0.753374103 1.7 0.113246 0 hsa-miR-142-5p_st 2.56169858 5.9 0.013961 1 hsa-miR-650_st 0.730169717 1.7 0.010038 1 hsa-miR-513c_st 0.605038869 1.5 0.166732 0 hsa-miR-761_st 0.777426676 1.7 0.05169 0 hsa-let-7f-1-star_st 0.142846126 1.1 0.415137 0 hsa-miR-513a-5p_st 0.523435037 1.4 0.198806 0 hsa-miR-654-5p_st 0.249276505 1.2 0.360797 0 hsa-let-7g-star_st 0.156253707 1.1 0.148959 0 hsa-miR-3163_st 0.543188999 1.5 0.02872 1 hsa-let-7i-star_st 0.130185751 1.1 0.670973 0 hsa-miR-3165_st 0.43205265 1.3 0.16596 0 hsa-miR-3194_st 0.429406799 1.3 0.103363 0 hsa-miR-100-star_st −0.195570551 1.1 0.235634 0 hsa-miR-4251_st 0.578591196 1.5 0.132532 0 hsa-miR-101-star_st 0.012914493 1.0 0.960248 0 hsa-miR-922_st 0.711925981 1.6 0.014799 1 hsa-miR-103-2-star_st 0.350606284 1.3 0.253605 0 hsa-miR-155_st 1.798436129 3.5 0.014737 1 hsa-miR-105_st −0.233692782 1.2 0.442062 0 hsa-miR-127-5p_st 0.642003592 1.6 0.090898 0 hsa-miR-1286_st 0.743468778 1.7 0.05942 0 hsa-miR-106a-star_st −0.184227718 1.1 0.368139 0 hsa-miR-890_st 0.909456805 1.9 0.012924 1 hsa-miR-3126-5p_st 0.226396632 1.2 0.246346 0 hsa-miR-489_st 0.498037741 1.4 0.242395 0 hsa-miR-10a_st 0.030676675 1.0 0.886626 0 hsa-miR-10a-star_st 0.174697763 1.1 0.615306 0 hsa-miR-10b_st 0.047827215 1.0 0.779194 0 hsa-miR-10b-star_st 0.341931915 1.3 0.184372 0 hsa-miR-1178_st 0.047470858 1.0 0.769634 0 hsa-miR-1179_st −0.090584137 1.1 0.754225 0 hsa-miR-1180_st −0.31074378 1.2 0.601011 0 hsa-miR-1181_st 0.614349339 1.5 0.298981 0 hsa-miR-3138_st 0.278810901 1.2 0.408688 0 hsa-miR-220c_st 0.629203111 1.5 0.059606 0 hsa-miR-510_st 0.316980656 1.2 0.117429 0 hsa-miR-1185_st −0.128048893 1.1 0.639716 0 hsa-miR-1193_st −0.103716351 1.1 0.523278 0 hsa-miR-1197_st −0.310732889 1.2 0.078067 0 hsa-miR-1200_st 0.223603575 1.2 0.39149 0 hsa-miR-1201_st −0.075320777 1.1 0.227089 0 hsa-miR-1202_st −0.112431833 1.1 0.486393 0 hsa-miR-30c-1-star_st 0.380452272 1.3 0.065707 0 hsa-miR-1204_st 0.222358878 1.2 0.220054 0 hsa-miR-1205_st 0.33892738 1.3 0.272226 0 hsa-miR-1206_st −0.153352729 1.1 0.835432 0 hsa-miR-1207-3p_st −0.092422989 1.1 0.761077 0 hsa-miR-1207-5p_st −0.241697006 1.2 0.345079 0 hsa-miR-1208_st −0.177068911 1.1 0.912285 0 hsa-miR-622_st 0.538457109 1.5 0.010469 1 hsa-miR-1224-3p_st 0.187520742 1.1 0.446743 0 hsa-miR-2116_st 0.492500977 1.4 0.117165 0 hsa-miR-1225-3p_st 0.100043389 1.1 0.376665 0 hsa-miR-1225-5p_st −0.216538721 1.2 0.326366 0 hsa-miR-1226_st 0.05345221 1.0 0.63599 0 hsa-miR-30b-star_st 0.378859796 1.3 0.024537 1 hsa-miR-1227_st 0.177934835 1.1 0.235217 0 hsa-miR-1295_st 0.476249392 1.4 0.136194 0 hsa-miR-1228-star_st −0.460203769 1.4 0.135239 0 hsa-miR-20b_st 0.314717878 1.2 0.59429 0 hsa-miR-122-star_st −0.18321932 1.1 0.53654 0 hsa-miR-1231_st −0.359637397 1.3 0.147486 0 hsa-miR-1233_st −0.053097982 1.0 0.769955 0 hsa-miR-524-5p_st 0.799646437 1.7 0.020832 1 hsa-miR-1236_st 0.380144023 1.3 0.45589 0 hsa-miR-873_st 0.639177977 1.6 0.02933 1 hsa-miR-1238_st 0.14455622 1.1 0.308167 0 hsa-miR-124_st 0.115237657 1.1 0.443001 0 hsa-miR-1243_st 0.182963403 1.1 0.10554 0 hsa-miR-1244_st 0.442283194 1.4 0.28315 0 hsa-miR-1245_st −0.071613502 1.1 0.603549 0 hsa-miR-3122_st 0.136397635 1.1 0.407173 0 hsa-miR-134_st 0.182840295 1.1 0.537802 0 hsa-miR-1248_st 0.386913244 1.3 0.771592 0 hsa-miR-146a_st 1.721943675 3.3 0.046042 1 hsa-miR-124-star_st −0.036904116 1.0 0.526467 0 hsa-miR-1250_st −0.111162351 1.1 0.87748 0 hsa-miR-764_st 0.627906523 1.5 0.06263 0 hsa-miR-1252_st −0.17930367 1.1 0.21923 0 hsa-miR-223_st 1.450273001 2.7 0.020339 1 hsa-miR-34c-3p_st 0.359030798 1.3 0.43261 0 hsa-miR-1255a_st 0.644904909 1.6 0.1947 0 hsa-miR-1255b_st 0.206778521 1.2 0.943722 0 hsa-miR-1256_st −0.038585498 1.0 0.528789 0 hsa-miR-1257_st 0.483313452 1.4 0.094918 0 hsa-miR-199b-5p_st 1.374135983 2.6 0.002211 1 hsa-miR-1259_st −0.416334147 1.3 0.145578 0 hsa-miR-492_st 0.330597852 1.3 0.222847 0 hsa-miR-3132_st 0.376146181 1.3 0.084348 0 hsa-miR-516b_st 0.389547759 1.3 0.160611 0 hsa-miR-4294_st 0.267665335 1.2 0.484447 0 hsa-miR-125b-2-star_st 0.570600914 1.5 0.501618 0 hsa-miR-126_st −0.291752851 1.2 0.226422 0 hsa-miR-198_st 0.216067303 1.2 0.488113 0 hsa-miR-3191_st 0.428319564 1.3 0.273366 0 hsa-miR-1261_st 0.339073131 1.3 0.250594 0 hsa-miR-1262_st 0.246582458 1.2 0.237055 0 hsa-miR-1263_st 0.002994286 1.0 0.98887 0 hsa-miR-1264_st 0.129685159 1.1 0.504958 0 hsa-miR-1265_st −0.00478625 1.0 0.978527 0 hsa-miR-2114-star_st 0.434370937 1.4 0.590149 0 hsa-miR-1267_st −0.052505392 1.0 0.686661 0 hsa-miR-1268_st −0.311544831 1.2 0.395279 0 hsa-miR-1269_st 0.362377856 1.3 0.303275 0 hsa-miR-509-5p_st 0.475655138 1.4 0.128606 0 hsa-miR-1270_st −0.050719434 1.0 0.97721 0 hsa-miR-1271_st 0.271446664 1.2 0.161724 0 hsa-miR-4303_st 0.412391073 1.3 0.078033 0 hsa-miR-1273_st 0.165442504 1.1 0.947419 0 hsa-miR-583_st 0.687979689 1.6 0.027615 1 hsa-miR-1273d_st −0.013204854 1.0 0.906886 0 hsa-miR-127-3p_st 0.410577043 1.3 0.115024 0 hsa-miR-522-star_st 0.314980137 1.2 0.179915 0 hsa-miR-214-star_st 0.851687647 1.8 0.022454 1 hsa-miR-184_st 0.359357824 1.3 0.312376 0 hsa-miR-614_st 0.598523825 1.5 0.140224 0 hsa-miR-526b_st 0.521217217 1.4 0.097793 0 hsa-miR-1277_st −0.170162396 1.1 0.40409 0 hsa-miR-1278_st −0.172305953 1.1 0.462221 0 hsa-miR-1279_st 0.004626172 1.0 0.681663 0 hsa-miR-409-3p_st 0.768490808 1.7 0.000866 1 hsa-miR-199a-5p_st 0.827921846 1.8 0.0351 1 hsa-miR-1281_st 0.18164288 1.1 0.646935 0 hsa-miR-1282_st 0.623893244 1.5 0.205007 0 hsa-miR-33b-star_st 0.341258038 1.3 0.036234 1 hsa-miR-1284_st 0.501884007 1.4 0.299586 0 hsa-miR-1253_st 0.669248696 1.6 0.017339 1 hsa-miR-584_st 0.326999523 1.3 0.297353 0 hsa-miR-1287_st −0.015401509 1.0 0.553083 0 hsa-miR-15a_st 0.511485641 1.4 0.982591 0 hsa-miR-1289_st 0.041351958 1.0 0.855474 0 hsa-miR-1290_st −0.050188417 1.0 0.929735 0 hsa-miR-2117_st 0.506400174 1.4 0.043604 1 hsa-miR-1292_st −0.050843006 1.0 0.88824 0 hsa-miR-1293_st −0.073272405 1.1 0.739425 0 hsa-miR-129-3p_st −0.001693057 1.0 0.55594 0 hsa-miR-520d-5p_st 0.467552588 1.4 0.085284 0 hsa-miR-526a_st 0.578185042 1.5 0.028716 1 hsa-miR-129-5p_st −0.169948256 1.1 0.65617 0 hsa-miR-1254_st 0.148559927 1.1 0.439701 0 hsa-miR-1297_st −0.099944387 1.1 0.572545 0 hsa-miR-1298_st 0.539135199 1.5 0.182728 0 hsa-miR-1299_st 0.334121739 1.3 0.637893 0 hsa-miR-129-star_st 0.008650809 1.0 0.924159 0 hsa-miR-1301_st −0.02689071 1.0 0.694778 0 hsa-miR-19b_st 0.409106317 1.3 0.809645 0 hsa-miR-1303_st −0.162155607 1.1 0.903812 0 hsa-miR-1304_st 0.028103052 1.0 0.647933 0 hsa-miR-1305_st 0.294612715 1.2 0.585706 0 hsa-miR-550_st 0.366212669 1.3 0.263279 0 hsa-miR-1307_st −0.341057611 1.3 0.546509 0 hsa-miR-1308_st −0.069935135 1.0 0.130856 0 hsa-miR-4291_st 0.754340375 1.7 0.039109 1 hsa-miR-130a-star_st 0.028881865 1.0 0.691859 0 hsa-miR-130b_st 0.07684248 1.1 0.418256 0 hsa-miR-130b-star_st 0.093913981 1.1 0.277798 0 hsa-miR-921_st 0.195608523 1.1 0.445453 0 hsa-miR-520a-5p_st 0.576719796 1.5 0.007799 1 hsa-miR-711_st 0.260675292 1.2 0.321107 0 hsa-miR-1323_st 0.035822018 1.0 0.943835 0 hsa-miR-1324_st −0.13301591 1.1 0.627783 0 hsa-miR-490-3p_st 0.424119864 1.3 0.064365 0 hsa-miR-718_st 0.217732235 1.2 0.248671 0 hsa-miR-133b_st −0.469788265 1.4 0.917947 0 hsa-miR-431-star_st 0.147541588 1.1 0.018985 1 hsa-miR-552_st 0.343030797 1.3 0.445382 0 hsa-miR-28-3p_st 0.155071657 1.1 0.429667 0 hsa-miR-4265_st 0.152783398 1.1 0.763516 0 hsa-miR-643_st 0.503036953 1.4 0.071571 0 hsa-miR-136_st −0.20070054 1.1 0.374108 0 hsa-miR-136-star_st −0.064309513 1.0 0.452847 0 hsa-miR-137_st −0.260427174 1.2 0.097396 0 hsa-miR-138_st −1.084571389 2.1 0.076191 0 hsa-miR-138-1-star_st −0.107578237 1.1 0.735396 0 hsa-miR-138-2-star_st −0.115910616 1.1 0.471397 0 hsa-miR-139-3p_st 0.011765898 1.0 0.369208 0 hsa-miR-139-5p_st −0.948639603 1.9 0.148973 0 hsa-miR-140-3p_st 0.2619809 1.2 0.387848 0 hsa-miR-140-5p_st 0.682458919 1.6 0.513297 0 hsa-miR-381_st 0.571360316 1.5 0.041189 1 hsa-miR-141-star_st −0.022997755 1.0 0.773926 0 hsa-miR-17-star_st 0.296730861 1.2 0.069551 0 hsa-miR-4300_st 0.322573125 1.3 0.046109 1 hsa-miR-143_st −0.184341742 1.1 0.429635 0 hsa-miR-143-star_st −0.387219308 1.3 0.14521 0 hsa-miR-144_st −0.341966598 1.3 0.296928 0 hsa-miR-3198_st 0.164296782 1.1 0.241836 0 hsa-miR-145_st −0.682094867 1.6 0.162888 0 hsa-miR-145-star_st −0.163485512 1.1 0.66014 0 hsa-miR-1468_st 0.140185404 1.1 0.745272 0 hsa-miR-1469_st −0.563957441 1.5 0.051315 0 hsa-miR-1973_st 0.19433018 1.1 0.189619 0 hsa-miR-3154_st 0.179552967 1.1 0.248993 0 hsa-miR-148a-star_st 0.902934693 1.9 0.022192 1 hsa-miR-92a-1-star_st 0.132762782 1.1 0.196171 0 hsa-miR-147_st −0.085333922 1.1 0.953812 0 hsa-miR-194-star_st 0.145575377 1.1 0.348301 0 hsa-miR-1471_st 0.22006954 1.2 0.553971 0 hsa-miR-147b_st 0.147795482 1.1 0.156315 0 hsa-miR-148a_st 0.095586754 1.1 0.239099 0 hsa-miR-4299_st 0.247225958 1.2 0.588211 0 hsa-miR-135a-star_st 0.094731411 1.1 0.56718 0 hsa-miR-612_st 0.14154239 1.1 0.246254 0 hsa-miR-1321_st 0.292069649 1.2 0.132047 0 hsa-miR-149-star_st −0.496528448 1.4 0.069502 0 hsa-miR-604_st 0.368201664 1.3 0.602615 0 hsa-miR-150-star_st −0.160760929 1.1 0.380117 0 hsa-miR-125b-1-star_st 0.266214617 1.2 0.174494 0 hsa-miR-1183_st 0.172022645 1.1 0.286923 0 hsa-miR-152_st −0.634853536 1.6 0.131429 0 hsa-miR-153_st −0.322603156 1.3 0.208263 0 hsa-miR-1537_st −0.178492716 1.1 0.780523 0 hsa-miR-1538_st −0.254992422 1.2 0.413787 0 hsa-miR-1539_st −0.052246194 1.0 0.752834 0 hsa-miR-154_st 0.259776045 1.2 0.365195 0 hsa-miR-154-star_st 0.498869548 1.4 0.070034 0 hsa-miR-432-star_st 0.577613365 1.5 0.042533 1 hsa-miR-155-star_st −0.42954563 1.3 0.094111 0 hsa-miR-298_st 0.189320666 1.1 0.269543 0 hsa-miR-15a-star_st 0.211556396 1.2 0.631205 0 hsa-miR-2110_st 0.185897965 1.1 0.444748 0 hsa-miR-15b-star_st 0.028843654 1.0 0.723751 0 hsa-miR-1266_st 0.095158208 1.1 0.449161 0 hsa-miR-16-1-star_st 0.129889439 1.1 0.926047 0 hsa-miR-16-2-star_st 0.186499866 1.1 0.941051 0 hsa-miR-490-5p_st 0.272356707 1.2 0.299292 0 hsa-miR-19a_st 0.577445133 1.5 0.585889 0 hsa-miR-3192_st 0.119080009 1.1 0.231625 0 hsa-miR-3155_st 0.36929577 1.3 0.016146 1 hsa-miR-187-star_st −0.040562667 1.0 0.993231 0 hsa-miR-16_st 0.220122823 1.2 0.916486 0 hsa-miR-936_st 0.110515944 1.1 0.314959 0 hsa-miR-181c-star_st 0.240336314 1.2 0.462049 0 hsa-miR-379_st 0.661853147 1.6 0.00289 1 hsa-miR-370_st 0.006963913 1.0 0.851394 0 hsa-miR-541_st 0.190010878 1.1 0.352851 0 hsa-miR-518c-star_st 0.192841849 1.1 0.270646 0 hsa-miR-487b_st 0.298745781 1.2 0.842984 0 hsa-miR-182-star_st −0.252195791 1.2 0.25357 0 hsa-miR-3121_st 0.358597185 1.3 0.49505 0 hsa-miR-3190-5p_st 0.065396988 1.0 0.40608 0 hsa-miR-1203_st 0.151413387 1.1 0.391938 0 hsa-miR-185_st 0.144429706 1.1 0.961782 0 hsa-miR-185-star_st −0.086787621 1.1 0.545045 0 hsa-miR-4317_st 0.31451382 1.2 0.479108 0 hsa-miR-186-star_st 0.016389215 1.0 0.832989 0 hsa-miR-187_st 0.444649968 1.4 0.157438 0 hsa-miR-4257_st 0.029746602 1.0 0.981628 0 hsa-miR-188-3p_st 0.273185757 1.2 0.305809 0 hsa-miR-1184_st 0.589679414 1.5 0.05273 0 hsa-miR-18a_st 0.406035907 1.3 0.120102 0 hsa-miR-18a-star_st 0.298369992 1.2 0.397917 0 hsa-miR-3140_st 0.542698169 1.5 0.029979 1 hsa-miR-18b-star_st 0.139194953 1.1 0.407341 0 hsa-miR-190_st −0.359433873 1.3 0.174358 0 hsa-miR-601_st 0.08803042 1.1 0.71448 0 hsa-miR-1909_st −0.218546252 1.2 0.785095 0 hsa-miR-342-5p_st 0.535361666 1.4 0.042474 1 hsa-miR-575_st 0.049263204 1.0 0.412505 0 hsa-miR-885-5p_st 0.222495867 1.2 0.301399 0 hsa-miR-300_st 0.268796058 1.2 0.176561 0 hsa-miR-1911_st 0.166743537 1.1 0.333433 0 hsa-miR-1911-star_st 0.572929009 1.5 0.051711 0 hsa-miR-1912_st 0.146955006 1.1 0.317028 0 hsa-miR-4266_st 0.145134038 1.1 0.042949 1 hsa-miR-1914_st 0.070628747 1.1 0.59658 0 hsa-miR-3190-3p_st −0.037331733 1.0 0.78176 0 hsa-miR-618_st 0.494306949 1.4 0.04247 1 hsa-miR-1276_st 0.00351847 1.0 0.360422 0 hsa-miR-191-star_st 0.147510694 1.1 0.520521 0 hsa-miR-1258_st 0.275840254 1.2 0.04271 1 hsa-miR-192-star_st −0.06376955 1.0 0.525846 0 hsa-miR-193a-3p_st 0.022503659 1.0 0.880142 0 hsa-miR-193a-5p_st −0.403890343 1.3 0.21739 0 hsa-miR-3157_st 0.248581098 1.2 0.094905 0 hsa-miR-193b-star_st −0.169180628 1.1 0.710155 0 hsa-miR-194_st −0.20492966 1.2 0.528825 0 hsa-miR-4307_st 0.562970988 1.5 0.016437 1 hsa-miR-195_st −0.360440708 1.3 0.10651 0 hsa-miR-610_st 0.438112863 1.4 0.03075 1 hsa-miR-196a_st 0.144397279 1.1 0.986012 0 hsa-miR-196a-star_st 0.060957058 1.0 0.279451 0 hsa-miR-196b_st −0.316349895 1.2 0.08753 0 hsa-miR-196b-star_st 0.19969431 1.1 0.30428 0 hsa-let-7f-2-star_st 0.448215724 1.4 0.027173 1 hsa-miR-1972_st 0.090137215 1.1 0.938615 0 hsa-miR-3184_st 0.020283069 1.0 0.220167 0 hsa-miR-523-star_st 0.161139449 1.1 0.341426 0 hsa-miR-1976_st 0.442441254 1.4 0.426464 0 hsa-miR-625-star_st 0.429714114 1.3 0.001811 1 hsa-miR-587_st 0.220743245 1.2 0.359828 0 hsa-miR-199a-3p_st 0.585986358 1.5 0.068287 0 hsa-miR-1910_st 0.139234923 1.1 0.14963 0 hsa-miR-199b-3p_st 0.352619157 1.3 0.189896 0 hsa-miR-639_st −0.052286492 1.0 0.608086 0 hsa-miR-1909-star_st 0.383667591 1.3 0.006294 1 hsa-miR-19a-star_st −0.272056542 1.2 0.287445 0 hsa-miR-29c-star_st −0.559030052 1.5 0.256118 0 hsa-miR-940_st 0.069355857 1.0 0.287876 0 hsa-miR-19b-2-star_st −0.09964156 1.1 0.818241 0 hsa-miR-4269_st 0.221680435 1.2 0.126453 0 hsa-miR-200a-star_st 0.130237044 1.1 0.359164 0 hsa-miR-1182_st −0.056682666 1.0 0.597884 0 hsa-miR-518f-star_st 0.382805669 1.3 0.023402 1 hsa-miR-92a-2-star_st 0.065203117 1.0 0.319181 0 hsa-miR-200c-star_st −0.07689136 1.1 0.607763 0 hsa-miR-202_st 0.132661941 1.1 0.420546 0 hsa-miR-202-star_st −0.416230508 1.3 0.139646 0 hsa-miR-1914-star_st 0.039930461 1.0 0.71646 0 hsa-miR-204_st −1.360806389 2.6 0.235145 0 hsa-miR-665_st 0.152707278 1.1 0.142516 0 hsa-miR-2052_st −0.250939013 1.2 0.25587 0 hsa-miR-2053_st −0.29620062 1.2 0.31199 0 hsa-miR-2054_st −0.427536801 1.3 0.32845 0 hsa-miR-205-star_st −0.061640286 1.0 0.973845 0 hsa-miR-206_st 0.454007399 1.4 0.056038 0 hsa-miR-208a_st −0.084780951 1.1 0.740568 0 hsa-miR-208b_st 0.085598792 1.1 0.731521 0 hsa-miR-18b_st 0.350917932 1.3 0.012977 1 hsa-miR-20a-star_st 0.356726338 1.3 0.659528 0 hsa-miR-3181_st −0.073987421 1.1 0.581726 0 hsa-miR-615-5p_st 0.050775889 1.0 0.117573 0 hsa-miR-4259_st −0.088211305 1.1 0.739551 0 hsa-miR-210_st −0.198670803 1.1 0.754396 0 hsa-miR-211_st 0.083674094 1.1 0.644261 0 hsa-miR-887_st 0.088567536 1.1 0.207835 0 hsa-miR-2113_st 0.682135969 1.6 0.12567 0 hsa-miR-2114_st 0.173258011 1.1 0.224163 0 hsa-miR-943_st 0.017562171 1.0 0.864482 0 hsa-miR-2115_st −0.09669143 1.1 0.60714 0 hsa-miR-2115-star_st −0.266414089 1.2 0.199105 0 hsa-miR-183-star_st 0.240227093 1.2 0.399326 0 hsa-miR-2116-star_st 0.341008264 1.3 0.131291 0 hsa-miR-920_st 0.024508378 1.0 0.544312 0 hsa-miR-212_st 0.324357181 1.3 0.070228 0 hsa-miR-214_st 0.278133685 1.2 0.137009 0 hsa-miR-1825_st 0.364615919 1.3 0.069404 0 hsa-miR-215_st 0.703710939 1.6 0.168019 0 hsa-miR-216a_st 0.028005855 1.0 0.947679 0 hsa-miR-195-star_st 0.535808084 1.4 0.082091 0 hsa-miR-217_st −0.248213761 1.2 0.261048 0 hsa-miR-23a-star_st 0.088641418 1.1 0.587624 0 hsa-miR-25-star_st −0.009084933 1.0 0.486094 0 hsa-miR-218-2-star_st 0.118423806 1.1 0.2265 0 hsa-miR-1273c_st 0.249749016 1.2 0.584105 0 hsa-miR-219-2-3p_st 0.040706344 1.0 0.529187 0 hsa-miR-637_st −0.133965798 1.1 0.829827 0 hsa-miR-21-star_st 0.628304942 1.5 0.053729 0 hsa-miR-22_st −0.481594244 1.4 0.133164 0 hsa-miR-220a_st −0.089116741 1.1 0.722455 0 hsa-miR-220b_st −0.084712989 1.1 0.929793 0 hsa-miR-219-1-3p_st 0.240275924 1.2 0.057287 0 hsa-miR-4316_st 0.037435645 1.0 0.647248 0 hsa-miR-877_st −0.074134772 1.1 0.914585 0 hsa-miR-636_st 0.045553357 1.0 0.541566 0 hsa-miR-3177_st −0.12101774 1.1 0.98502 0 hsa-miR-1249_st 0.269924164 1.2 0.046071 1 hsa-miR-223-star_st 0.392485906 1.3 0.145991 0 hsa-miR-1224-5p_st −0.041667436 1.0 0.664727 0 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1.1 0.476498 0 hsa-miR-483-5p_st 0.072187585 1.1 0.617728 0 hsa-miR-1306_st 0.094554231 1.1 0.479575 0 hsa-miR-431_st 0.195065481 1.1 0.024129 1 hsa-miR-765_st 0.063301125 1.0 0.236606 0 hsa-miR-2909_st −0.234768551 1.2 0.215933 0 hsa-miR-296-3p_st −0.111423297 1.1 0.803913 0 hsa-miR-296-5p_st 0.171546983 1.1 0.220193 0 hsa-miR-297_st 0.383566532 1.3 0.31691 0 hsa-miR-323b-5p_st 0.242872311 1.2 0.253737 0 hsa-miR-299-3p_st 0.305249178 1.2 0.139037 0 hsa-miR-299-5p_st −0.247295581 1.2 0.402571 0 hsa-miR-487a_st 0.081306244 1.1 0.532351 0 hsa-miR-29a-star_st −0.022166912 1.0 0.906334 0 hsa-miR-625_st 0.62931785 1.5 0.000114 1 hsa-miR-611_st 0.073601097 1.1 0.148153 0 hsa-miR-3186-3p_st 0.114238135 1.1 0.108442 0 hsa-miR-1294_st 0.221203458 1.2 0.026848 1 hsa-miR-3147_st −0.17353218 1.1 0.817427 0 hsa-miR-4285_st −0.23358084 1.2 0.984675 0 hsa-miR-125a-3p_st 0.130241195 1.1 0.367499 0 hsa-miR-301b_st −0.120914885 1.1 0.510285 0 hsa-miR-302a_st −0.119136838 1.1 0.708886 0 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0.317196 0 hsa-miR-3134_st 0.231473678 1.2 0.226633 0 hsa-miR-3135_st 0.171198221 1.1 0.641851 0 hsa-miR-3136_st −0.124747728 1.1 0.721364 0 hsa-miR-19b-1-star_st −0.117639424 1.1 0.934124 0 hsa-miR-1247_st −0.143941086 1.1 0.565652 0 hsa-miR-3139_st 0.046745612 1.0 0.286044 0 hsa-miR-596_st 0.098567312 1.1 0.077547 0 hsa-miR-3141_st −0.324538175 1.3 0.370717 0 hsa-miR-3142_st −0.334752295 1.3 0.293943 0 hsa-miR-1302_st −0.202628829 1.2 0.245605 0 hsa-miR-3144-3p_st 0.468244668 1.4 0.257366 0 hsa-miR-3144-5p_st 0.552061596 1.5 0.15142 0 hsa-miR-3145_st −0.052818993 1.0 0.876659 0 hsa-miR-3146_st 0.114071261 1.1 0.725827 0 hsa-miR-346_st 0.082782051 1.1 0.711318 0 hsa-miR-4256_st 0.055587343 1.0 0.190026 0 hsa-miR-3149_st 0.264424446 1.2 0.301062 0 hsa-miR-3150_st −0.057615289 1.0 0.377404 0 hsa-miR-3151_st −0.13683372 1.1 0.735127 0 hsa-miR-1470_st 0.06309613 1.0 0.0732 0 hsa-miR-3153_st 0.158659896 1.1 0.31969 0 hsa-miR-514_st −0.255112571 1.2 0.024471 1 hsa-miR-3175_st −0.090171011 1.1 0.025631 1 hsa-miR-3156_st 0.01042151 1.0 0.663664 0 hsa-miR-504_st −0.354647647 1.3 0.248216 0 hsa-miR-3158_st 0.242012898 1.2 0.387274 0 hsa-miR-3159_st 0.130087668 1.1 0.220911 0 hsa-miR-3160_st 0.361948767 1.3 0.25058 0 hsa-miR-3161_st 0.33659093 1.3 0.859574 0 hsa-miR-3162_st −0.085678651 1.1 0.524787 0 hsa-miR-1234_st −0.091927645 1.1 0.030069 1 hsa-miR-3164_st 0.346374988 1.3 0.266081 0 hsa-miR-516b-star_st −0.203440083 1.2 0.215677 0 hsa-miR-3166_st −0.181213397 1.1 0.660455 0 hsa-miR-4327_st −0.233728282 1.2 0.41463 0 hsa-miR-3168_st −0.216039337 1.2 0.57451 0 hsa-miR-3169_st 0.051137454 1.0 0.552598 0 hsa-miR-3170_st 0.320988357 1.2 0.148907 0 hsa-miR-3171_st −0.242069253 1.2 0.136424 0 hsa-miR-3172_st −0.515194022 1.4 0.070227 0 hsa-miR-374b-star_st −0.135881605 1.1 0.166965 0 hsa-miR-34c-5p_st −0.137648123 1.1 0.232896 0 hsa-miR-758_st −0.42411508 1.3 0.018479 1 hsa-miR-3176_st −0.394622078 1.3 0.575357 0 hsa-miR-606_st −0.238257927 1.2 0.14124 0 hsa-miR-3178_st −0.313925385 1.2 0.268607 0 hsa-miR-3179_st 0.026344761 1.0 0.8203 0 hsa-miR-3180-3p_st −0.336927668 1.3 0.412272 0 hsa-miR-597_st −0.226188253 1.2 0.14718 0 hsa-miR-148b-star_st −0.196406099 1.1 0.298728 0 hsa-miR-3182_st 0.078928423 1.1 0.800725 0 hsa-miR-3183_st 0.119947781 1.1 0.721543 0 hsa-miR-144-star_st −0.306543697 1.2 0.036562 1 hsa-miR-3185_st −0.398312207 1.3 0.214967 0 hsa-miR-4270_st −0.311916829 1.2 0.187261 0 hsa-miR-3186-5p_st 0.268683048 1.2 0.485646 0 hsa-miR-3187_st −0.195651659 1.1 0.630086 0 hsa-miR-3188_st −0.233796974 1.2 0.37223 0 hsa-miR-3189_st 0.013209335 1.0 0.303601 0 hsa-miR-548b-3p_st −0.394103938 1.3 0.16976 0 hsa-miR-99a-star_st −0.14210008 1.1 0.267534 0 hsa-miR-376a-star_st −0.438856306 1.4 0.026751 1 hsa-miR-216b_st −0.254423156 1.2 0.551732 0 hsa-miR-3193_st 0.129391264 1.1 0.743454 0 hsa-miR-548v_st −0.415816203 1.3 0.008072 1 hsa-miR-26a-1-star_st 0.061401517 1.0 0.689128 0 hsa-miR-1291_st −0.16112209 1.1 0.0205 1 hsa-miR-3197_st −0.120456811 1.1 0.361294 0 hsa-miR-629_st −0.037895518 1.0 0.453804 0 hsa-miR-3199_st 0.135592462 1.1 0.499345 0 hsa-miR-190b_st −0.480972754 1.4 0.001896 1 hsa-miR-32_st −0.419442578 1.3 0.164795 0 hsa-miR-3200_st −0.126930699 1.1 0.493669 0 hsa-miR-3201_st −0.036710166 1.0 0.821673 0 hsa-miR-3202_st 0.402999655 1.3 0.101864 0 hsa-miR-320a_st −0.251451643 1.2 0.558959 0 hsa-miR-4289_st −0.270829537 1.2 0.597481 0 hsa-miR-655_st −0.368556761 1.3 0.158592 0 hsa-miR-320b_st −0.35253325 1.3 0.186899 0 hsa-miR-219-5p_st −0.328121945 1.3 0.051686 0 hsa-miR-323-3p_st 0.125301285 1.1 0.673919 0 hsa-miR-323-5p_st −0.052004644 1.0 0.975905 0 hsa-miR-323b-3p_st −0.013270906 1.0 0.333781 0 hsa-miR-103-as_st −0.187222262 1.1 0.013297 1 hsa-miR-424-star_st −0.228529563 1.2 0.105266 0 hsa-miR-33a-star_st 0.025569587 1.0 0.569404 0 hsa-miR-325_st 0.129207092 1.1 0.591898 0 hsa-miR-590-3p_st −0.33515707 1.3 0.13373 0 hsa-miR-328_st −0.653137058 1.6 0.202436 0 hsa-miR-329_st 0.244769264 1.2 0.259484 0 hsa-miR-32-star_st 0.299083019 1.2 0.231699 0 hsa-miR-330-3p_st 0.383022441 1.3 0.090106 0 hsa-miR-330-5p_st 0.006143569 1.0 0.445408 0 hsa-miR-146a-star_st −0.257439252 1.2 0.097765 0 hsa-miR-331-5p_st 0.066384289 1.0 0.942027 0 hsa-miR-3167_st −0.259626583 1.2 0.287251 0 hsa-miR-335-star_st 0.358874478 1.3 0.792819 0 hsa-miR-337-3p_st 0.479395538 1.4 0.292348 0 hsa-miR-337-5p_st 0.137743692 1.1 0.159703 0 hsa-miR-421_st 0.119392636 1.1 0.7771 0 hsa-miR-338-5p_st 0.038763558 1.0 0.491261 0 hsa-miR-339-3p_st −0.042717967 1.0 0.463727 0 hsa-miR-548a-5p_st −0.429059365 1.3 0.014966 1 hsa-miR-33a_st −0.313173638 1.2 0.245048 0 hsa-miR-590-5p_st −0.211078204 1.2 0.250467 0 hsa-miR-33b_st −0.287905206 1.2 0.33353 0 hsa-miR-616-star_st −0.392399674 1.3 0.030131 1 hsa-miR-569_st −0.315730178 1.2 0.156427 0 hsa-miR-340-star_st −0.173004694 1.1 0.329519 0 hsa-miR-342-3p_st 0.872504154 1.8 0.156627 0 hsa-miR-135b-star_st −0.264994046 1.2 0.014113 1 hsa-miR-345_st −0.716548174 1.6 0.161559 0 hsa-miR-1288_st 0.083971989 1.1 0.922635 0 hsa-miR-135a_st −0.426929078 1.3 0.000433 1 hsa-miR-34a-star_st 0.434256293 1.4 0.881006 0 hsa-miR-34b_st 0.510326166 1.4 0.099675 0 hsa-miR-4288_st −0.202327966 1.2 0.044094 1 hsa-miR-222-star_st 0.903411912 1.9 0.024026 1 hsa-miR-933_st −0.261696727 1.2 0.269561 0 hsa-miR-361-3p_st −0.194631233 1.1 0.971136 0 hsa-miR-224-star_st −0.141823241 1.1 0.837286 0 hsa-miR-362-3p_st 0.601119039 1.5 0.515 0 hsa-miR-362-5p_st 0.124069134 1.1 0.770287 0 hsa-miR-363_st 0.763458508 1.7 0.126319 0 hsa-miR-363-star_st 0.228016924 1.2 0.096887 0 hsa-miR-1979_st −0.584991801 1.5 0.019293 1 hsa-miR-365-star_st −0.202570494 1.2 0.738511 0 hsa-miR-548x_st −0.327986435 1.3 0.07609 0 hsa-miR-367-star_st −0.025933456 1.0 0.94268 0 hsa-miR-369-3p_st −0.112820683 1.1 0.52116 0 hsa-miR-369-5p_st 0.003359916 1.0 0.927553 0 hsa-miR-548l_st 0.048681172 1.0 0.756705 0 hsa-miR-371-3p_st 0.218615609 1.2 0.245427 0 hsa-miR-371-5p_st −0.238001731 1.2 0.725143 0 hsa-miR-372_st 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0.035583 1 hsa-miR-382_st 0.111919473 1.1 0.656666 0 hsa-miR-383_st 0.293267945 1.2 0.229382 0 hsa-miR-384_st −0.392836875 1.3 0.300101 0 hsa-miR-126-star_st −0.399345752 1.3 0.034858 1 hsa-miR-409-5p_st −0.12414789 1.1 0.874792 0 hsa-miR-410_st 0.006697404 1.0 0.469478 0 hsa-miR-411_st 0.271150668 1.2 0.246715 0 hsa-miR-411-star_st 0.309570329 1.2 0.261571 0 hsa-miR-412_st 0.071442552 1.1 0.540408 0 hsa-miR-3143_st −0.316632811 1.2 0.158183 0 hsa-miR-422a_st 0.105923567 1.1 0.88658 0 hsa-miR-628-5p_st −0.453495757 1.4 0.029429 1 hsa-miR-423-5p_st −0.096535656 1.1 0.905582 0 hsa-miR-27b-star_st 0.445837838 1.4 0.219383 0 hsa-miR-499-5p_st −0.374969431 1.3 0.012163 1 hsa-miR-425_st 0.214264038 1.2 0.73765 0 hsa-miR-193b_st −0.328445081 1.3 0.985986 0 hsa-miR-4252_st 0.041226352 1.0 0.625325 0 hsa-miR-4253_st −0.18368008 1.1 0.810606 0 hsa-miR-4254_st 0.287856229 1.2 0.334793 0 hsa-miR-324-3p_st −0.547703445 1.5 0.015682 1 hsa-miR-4329_st −0.409865962 1.3 0.171829 0 hsa-miR-1251_st −0.299625111 1.2 0.219551 0 hsa-miR-4258_st 0.107164085 1.1 0.552863 0 hsa-miR-1274a_st 0.416373316 1.3 0.212083 0 hsa-miR-425-star_st 0.285997573 1.2 0.231456 0 hsa-miR-4260_st −0.114314779 1.1 0.916543 0 hsa-miR-4261_st 0.217255454 1.2 0.584209 0 hsa-miR-4262_st 0.027979812 1.0 0.908204 0 hsa-miR-4263_st 0.185457336 1.1 0.186157 0 hsa-miR-4264_st −0.082514104 1.1 0.796352 0 hsa-miR-1280_st −0.499265528 1.4 0.028172 1 hsa-miR-132-star_st 0.195738177 1.1 0.537453 0 hsa-miR-4267_st −0.39549593 1.3 0.705016 0 hsa-miR-4268_st −0.24158889 1.2 0.297297 0 hsa-miR-133a_st −0.799885056 1.7 0.247447 0 hsa-miR-888-star_st 0.002338696 1.0 0.795839 0 hsa-miR-1260b_st −0.499880282 1.4 0.011008 1 hsa-miR-4272_st −0.274324827 1.2 0.290413 0 hsa-miR-4273_st 0.160997101 1.1 0.884204 0 hsa-miR-4274_st −0.00677725 1.0 0.366125 0 hsa-miR-4275_st −0.378201099 1.3 0.076063 0 hsa-miR-4276_st −0.1758286 1.1 0.987038 0 hsa-miR-4277_st 0.103006907 1.1 0.547518 0 hsa-miR-4278_st −0.201991483 1.2 0.840443 0 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0.011504 1 hsa-miR-4301_st −0.395404911 1.3 0.232709 0 hsa-miR-4302_st −0.149952641 1.1 0.96444 0 hsa-miR-365_st −0.796256029 1.7 0.028729 1 hsa-miR-4304_st 0.340604197 1.3 0.210005 0 hsa-miR-4305_st −0.136916788 1.1 0.561748 0 hsa-miR-4306_st 0.298020807 1.2 0.230751 0 hsa-miR-26a_st −0.38244862 1.3 0.225316 0 hsa-miR-4308_st −0.143032922 1.1 0.60723 0 hsa-miR-4309_st −0.098478831 1.1 0.509835 0 hsa-miR-186_st −0.149823159 1.1 0.622279 0 hsa-miR-4310_st 0.229518119 1.2 0.170438 0 hsa-miR-4311_st 0.289005441 1.2 0.123099 0 hsa-miR-4312_st 0.256785738 1.2 0.627573 0 hsa-miR-4313_st −0.324229329 1.3 0.231956 0 hsa-miR-4314_st 0.396062469 1.3 0.187354 0 hsa-miR-4315_st 0.505194646 1.4 0.101405 0 hsa-miR-149_st −0.157854206 1.1 0.434131 0 hsa-miR-106b-star_st −0.398408826 1.3 0.704568 0 hsa-miR-4318_st 0.264399722 1.2 0.272967 0 hsa-miR-4319_st 0.392306268 1.3 0.30148 0 hsa-miR-29b-2-star_st −0.202934828 1.2 0.409929 0 hsa-miR-432_st −0.197757106 1.1 0.700814 0 hsa-miR-4320_st 0.055104544 1.0 0.855596 0 hsa-miR-522_st −0.243105072 1.2 0.088311 0 hsa-miR-4322_st −0.254153034 1.2 0.635321 0 hsa-miR-4323_st 0.240735608 1.2 0.090052 0 hsa-miR-93-star_st −0.443254552 1.4 0.023149 1 hsa-miR-4325_st 0.029003291 1.0 0.850711 0 hsa-miR-4326_st 0.019063849 1.0 0.717733 0 hsa-miR-874_st −0.016194793 1.0 0.450244 0 hsa-miR-4328_st 0.039040676 1.0 0.589432 0 hsa-let-7e-star_st −0.391583213 1.3 0.363255 0 hsa-miR-720_st −0.522355883 1.4 0.041567 1 hsa-miR-433_st 0.186443419 1.1 0.404195 0 hsa-miR-4330_st 0.649618116 1.6 0.304572 0 hsa-miR-448_st −0.344394475 1.3 0.420657 0 hsa-miR-449a_st 0.111629787 1.1 0.275298 0 hsa-miR-449b_st 0.261733339 1.2 0.298153 0 hsa-miR-1975_st −0.543566756 1.5 0.03636 1 hsa-miR-449c_st −0.350685049 1.3 0.826556 0 hsa-miR-449c-star_st 0.198234894 1.1 0.496224 0 hsa-miR-1_st −0.658541042 1.6 0.379555 0 hsa-miR-450b-3p_st −0.26865447 1.2 0.269257 0 hsa-miR-450b-5p_st −0.219833545 1.2 0.304435 0 hsa-miR-451_st 0.119434024 1.1 0.851313 0 hsa-miR-452_st 0.481331997 1.4 0.133942 0 hsa-miR-452-star_st −0.160217591 1.1 0.184628 0 hsa-miR-548b-5p_st 0.064886625 1.0 0.997663 0 hsa-miR-454-star_st 0.387939462 1.3 0.097588 0 hsa-miR-455-3p_st −0.256693419 1.2 0.751639 0 hsa-miR-455-5p_st −0.153420578 1.1 0.825595 0 hsa-miR-466_st 0.185178668 1.1 0.670737 0 hsa-miR-483-3p_st −0.189467908 1.1 0.707198 0 hsa-miR-17_st 0.11943726 1.1 0.905865 0 hsa-miR-320d_st −0.628783294 1.5 0.202497 0 hsa-miR-485-3p_st 0.338059737 1.3 0.340176 0 hsa-miR-485-5p_st 0.191608916 1.1 0.427966 0 hsa-miR-486-3p_st −0.17975227 1.1 0.480174 0 hsa-miR-486-5p_st −0.743273431 1.7 0.643843 0 hsa-miR-644_st 0.0194628 1.0 0.973767 0 hsa-miR-3152_st 0.24060656 1.2 0.520603 0 hsa-miR-488_st 0.126437783 1.1 0.699516 0 hsa-miR-488-star_st 0.041580865 1.0 0.40329 0 hsa-miR-450a_st −0.108702892 1.1 0.396352 0 hsa-miR-20a_st 0.344046068 1.3 0.495483 0 hsa-miR-484_st −0.500126791 1.4 0.135309 0 hsa-miR-491-3p_st 0.060504977 1.0 0.952596 0 hsa-miR-491-5p_st 0.030698298 1.0 0.584523 0 hsa-miR-197_st −0.696883063 1.6 0.044 1 hsa-miR-493_st 0.035999181 1.0 0.796909 0 hsa-miR-493-star_st 0.509258241 1.4 0.197965 0 hsa-miR-494_st −0.130398234 1.1 0.097488 0 hsa-miR-495_st 0.286205387 1.2 0.407756 0 hsa-miR-496_st −0.268513169 1.2 0.420812 0 hsa-miR-497_st −0.165608648 1.1 0.318572 0 hsa-miR-497-star_st 0.026392223 1.0 0.72276 0 hsa-miR-498_st −0.176676534 1.1 0.760928 0 hsa-miR-499-3p_st −0.023963772 1.0 0.287539 0 hsa-miR-24-1-star_st −0.247986316 1.2 0.40637 0 hsa-miR-340_st −0.064628232 1.0 0.475878 0 hsa-miR-500b_st 0.148753511 1.1 0.659832 0 hsa-miR-500-star_st 0.014843554 1.0 0.578955 0 hsa-miR-501-3p_st −0.007863155 1.0 0.794506 0 hsa-miR-501-5p_st −0.048432641 1.0 0.603738 0 hsa-miR-502-3p_st 0.001674817 1.0 0.373789 0 hsa-miR-502-5p_st 0.285542036 1.2 0.370688 0 hsa-miR-503_st −0.403490078 1.3 0.346126 0 hsa-miR-192_st 0.125650546 1.1 0.904627 0 hsa-let-7g_st −0.363501397 1.3 0.216764 0 hsa-miR-505-star_st 0.091171325 1.1 0.794287 0 hsa-miR-506_st −0.23767302 1.2 0.135341 0 hsa-miR-507_st −0.090093514 1.1 0.945494 0 hsa-miR-508-3p_st −0.147273458 1.1 0.359695 0 hsa-miR-508-5p_st 0.002413732 1.0 0.563613 0 hsa-miR-509-3-5p_st 0.570714998 1.5 0.14875 0 hsa-miR-509-3p_st 0.128220498 1.1 0.913518 0 hsa-miR-106a_st 0.101378491 1.1 0.946798 0 hsa-miR-106b_st 0.185179199 1.1 0.563126 0 hsa-miR-511_st 0.085185017 1.1 0.526099 0 hsa-miR-512-3p_st 0.064685789 1.0 0.354096 0 hsa-miR-512-5p_st 0.503000395 1.4 0.179486 0 hsa-miR-513a-3p_st −0.05657031 1.0 0.62999 0 hsa-miR-23a_st −0.434948759 1.4 0.212513 0 hsa-miR-25_st −0.185716551 1.1 0.46048 0 hsa-miR-598_st −0.191799391 1.1 0.513132 0 hsa-miR-1260_st −0.403205051 1.3 0.056879 0 hsa-miR-514b-3p_st 0.07425613 1.1 0.822853 0 hsa-miR-514b-5p_st 0.067846485 1.0 0.919044 0 hsa-miR-515-3p_st 0.084059464 1.1 0.865942 0 hsa-miR-515-5p_st −0.2143596 1.2 0.405633 0 hsa-miR-516a-3p_st −0.329152416 1.3 0.174738 0 hsa-miR-27a_st −0.008736244 1.0 0.552974 0 hsa-miR-100_st −0.700600673 1.6 0.140808 0 hsa-miR-101_st −0.005977347 1.0 0.945932 0 hsa-miR-517a_st 0.04727117 1.0 0.591028 0 hsa-miR-517b_st −0.089526955 1.1 0.633292 0 hsa-miR-517c_st −0.20363942 1.2 0.248041 0 hsa-miR-517-star_st 0.196586726 1.1 0.260688 0 hsa-miR-518a-3p_st 0.011247929 1.0 0.863137 0 hsa-miR-518a-5p_st 0.07097453 1.1 0.951435 0 hsa-miR-518b_st −0.16618584 1.1 0.805289 0 hsa-miR-518c_st −0.278928886 1.2 0.164114 0 hsa-miR-301a_st −0.245009462 1.2 0.403999 0 hsa-miR-518d-3p_st −0.211708439 1.2 0.439569 0 hsa-miR-518d-5p_st 0.1436207 1.1 0.668487 0 hsa-miR-518e_st −0.099638468 1.1 0.654467 0 hsa-let-7f_st −0.694731549 1.6 0.08495 0 hsa-miR-518f_st −0.05927946 1.0 0.835217 0 hsa-miR-1826_st −0.554018667 1.5 0.040821 1 hsa-miR-519a_st −0.219384895 1.2 0.352649 0 hsa-miR-519a-star_st 0.093514792 1.1 0.641192 0 hsa-miR-519b-3p_st −0.425182678 1.3 0.186583 0 hsa-miR-1283_st −0.155943273 1.1 0.371834 0 hsa-miR-519c-3p_st −0.22575524 1.2 0.264196 0 hsa-miR-519c-5p_st 0.154654271 1.1 0.111986 0 hsa-miR-519d_st −0.061202395 1.0 0.969483 0 hsa-miR-519e_st −0.192296554 1.1 0.199336 0 hsa-miR-519e-star_st 0.488619628 1.4 0.358655 0 hsa-miR-520a-3p_st 0.362513338 1.3 0.095464 0 hsa-miR-1908_st −0.575629916 1.5 0.046413 1 hsa-miR-520b_st −0.019244537 1.0 0.842801 0 hsa-miR-520c-3p_st −0.051537511 1.0 0.817038 0 hsa-miR-520c-5p_st 0.327211186 1.3 0.556497 0 hsa-miR-181a-star_st −0.263148392 1.2 0.210917 0 hsa-miR-21_st 1.051650156 2.1 0.388359 0 hsa-miR-520e_st −0.052259144 1.0 0.957308 0 hsa-miR-520f_st −0.046481814 1.0 0.714076 0 hsa-miR-520g_st 0.055817922 1.0 0.676425 0 hsa-miR-520h_st −0.208974208 1.2 0.914089 0 hsa-miR-521_st −0.158149096 1.1 0.934861 0 hsa-miR-302a-star_st 0.05672264 1.0 0.845147 0 hsa-miR-886-3p_st −0.578085603 1.5 0.312507 0 hsa-miR-523_st −0.264297496 1.2 0.438418 0 hsa-miR-29a_st −0.073408757 1.1 0.344176 0 hsa-miR-524-3p_st −0.050976935 1.0 0.961604 0 hsa-miR-142-3p_st 0.208816551 1.2 0.812056 0 hsa-miR-525-3p_st −0.382656793 1.3 0.359001 0 hsa-miR-525-5p_st −0.158809165 1.1 0.289635 0 hsa-miR-762_st −0.575847028 1.5 0.045985 1 hsa-miR-423-3p_st −0.548028656 1.5 0.048835 1 hsa-miR-449b-star_st 0.267454021 1.2 0.722372 0 hsa-miR-527_st 0.055650744 1.0 0.90262 0 hsa-miR-532-3p_st −0.539471701 1.5 0.19665 0 hsa-miR-532-5p_st −0.060405467 1.0 0.699909 0 hsa-miR-539_st 0.312546568 1.2 0.162657 0 hsa-let-7a_st −0.824508829 1.8 0.065088 0 hsa-miR-541-star_st −0.010741527 1.0 0.540966 0 hsa-miR-542-3p_st 0.509143648 1.4 0.475878 0 hsa-miR-542-5p_st −0.005662111 1.0 0.951076 0 hsa-miR-543_st −0.36666952 1.3 0.111372 0 hsa-miR-544_st −0.184340516 1.1 0.687404 0 hsa-miR-544b_st −0.029458818 1.0 0.870442 0 hsa-miR-545_st −0.275002227 1.2 0.333558 0 hsa-miR-545-star_st −0.302436296 1.2 0.277267 0 hsa-miR-548a-3p_st −0.368344887 1.3 0.3328 0 hsa-miR-2861_st −0.583304924 1.5 0.042577 1 hsa-miR-31_st 1.298151333 2.5 0.009757 1 hsa-miR-367_st −0.245383145 1.2 0.203076 0 hsa-miR-548c-3p_st −0.327843687 1.3 0.471866 0 hsa-miR-548c-5p_st 0.370434943 1.3 0.618749 0 hsa-miR-548d-3p_st −0.081789967 1.1 0.919378 0 hsa-miR-548d-5p_st −0.094209604 1.1 0.901321 0 hsa-miR-548e_st −0.073613468 1.1 0.773161 0 hsa-miR-548f_st −0.451095109 1.4 0.163708 0 hsa-miR-548g_st −0.435901558 1.4 0.273558 0 hsa-miR-548h_st 0.048735427 1.0 0.622131 0 hsa-miR-548i_st 0.072545848 1.1 0.910885 0 hsa-miR-548j_st 0.107960665 1.1 0.132578 0 hsa-miR-548k_st −0.171818706 1.1 0.375565 0 hsa-miR-526b-star_st −0.183676733 1.1 0.383082 0 hsa-miR-548m_st −0.036584983 1.0 0.975121 0 hsa-miR-548n_st −0.024294044 1.0 0.968557 0 hsa-miR-548o_st −0.194656099 1.1 0.36543 0 hsa-miR-548p_st −0.131374209 1.1 0.667308 0 hsa-miR-548q_st −0.016155569 1.0 0.986717 0 hsa-miR-548s_st −0.097270292 1.1 0.391382 0 hsa-miR-548t_st 0.119312425 1.1 0.590276 0 hsa-miR-548u_st −0.364220565 1.3 0.522679 0 hsa-miR-638_st −0.584682732 1.5 0.04193 1 hsa-miR-548w_st −0.037738308 1.0 0.961521 0 hsa-miR-3119_st −0.131144411 1.1 0.493569 0 hsa-miR-549_st −0.026759829 1.0 0.783934 0 hsa-miR-205_st −0.51443685 1.4 0.527071 0 hsa-miR-550-star_st 0.339898545 1.3 0.12366 0 hsa-miR-551a_st 0.200977616 1.1 0.658473 0 hsa-miR-93_st −0.221641861 1.2 0.341126 0 hsa-miR-551b-star_st −0.277100035 1.2 0.241495 0 hsa-let-7d-star_st −0.817870789 1.8 0.001487 1 hsa-miR-553_st −0.160633104 1.1 0.577204 0 hsa-miR-554_st −0.000795591 1.0 0.840677 0 hsa-miR-555_st −0.265055834 1.2 0.21244 0 hsa-miR-556-3p_st −0.256410658 1.2 0.312103 0 hsa-miR-556-5p_st −0.508436488 1.4 0.095273 0 hsa-miR-557_st −0.13120445 1.1 0.699336 0 hsa-miR-558_st −0.179270174 1.1 0.53685 0 hsa-miR-559_st −0.18621429 1.1 0.526963 0 hsa-miR-561_st −0.331311185 1.3 0.360479 0 hsa-miR-562_st −0.386126782 1.3 0.097783 0 hsa-miR-563_st −0.064099224 1.0 0.773148 0 hsa-miR-361-5p_st −0.459382135 1.4 0.171234 0 hsa-miR-566_st −0.069353282 1.0 0.705441 0 hsa-miR-567_st −0.044060323 1.0 0.935407 0 hsa-miR-568_st −0.467525779 1.4 0.126731 0 hsa-miR-29c_st −0.269385247 1.2 0.155476 0 hsa-miR-570_st 0.016769609 1.0 0.753979 0 hsa-miR-571_st −0.359236634 1.3 0.202981 0 hsa-miR-572_st −0.267871647 1.2 0.677986 0 hsa-miR-573_st −0.114798921 1.1 0.366426 0 hsa-miR-132_st 0.028551986 1.0 0.872063 0 hsa-miR-574-5p_st 0.052700792 1.0 0.582451 0 hsa-let-7d_st −0.813804506 1.8 0.073832 0 hsa-miR-576-3p_st −0.176403738 1.1 0.868782 0 hsa-miR-576-5p_st 0.240554893 1.2 0.346771 0 hsa-miR-577_st −0.113892876 1.1 0.73489 0 hsa-miR-578_st 0.043736811 1.0 0.596228 0 hsa-miR-579_st −0.229910494 1.2 0.074895 0 hsa-miR-580_st −0.409276349 1.3 0.245493 0 hsa-miR-191_st −0.421916212 1.3 0.232485 0 hsa-miR-582-3p_st −0.098230602 1.1 0.647968 0 hsa-miR-582-5p_st 0.643724428 1.6 0.291378 0 hsa-miR-1915_st −0.586936222 1.5 0.040942 1 hsa-let-7c_st −0.892685551 1.9 0.069965 0 hsa-miR-585_st 0.002859563 1.0 0.576827 0 hsa-miR-586_st −0.122085304 1.1 0.530982 0 hsa-miR-324-5p_st −0.443964939 1.4 0.259965 0 hsa-miR-588_st 0.14579447 1.1 0.261043 0 hsa-miR-589_st 0.27336546 1.2 0.341313 0 hsa-miR-589-star_st −0.030803597 1.0 0.77687 0 hsa-miR-188-5p_st −0.243711215 1.2 0.141976 0 hsa-miR-103_st −0.477432941 1.4 0.190041 0 hsa-miR-591_st 0.095416174 1.1 0.697 0 hsa-miR-592_st −0.072083362 1.1 0.993985 0 hsa-miR-593_st −0.017418176 1.0 0.724079 0 hsa-miR-23b_st −0.617010375 1.5 0.095369 0 hsa-miR-595_st −0.085356748 1.1 0.898469 0 hsa-miR-99a_st −0.731185897 1.7 0.108421 0 hsa-miR-15b_st −0.517761071 1.4 0.251774 0 hsa-miR-135b_st −0.596496063 1.5 0.058175 0 hsa-miR-599_st −0.323584821 1.3 0.156143 0 hsa-miR-600_st −0.514436629 1.4 0.072178 0 hsa-miR-107_st −0.447493933 1.4 0.135448 0 hsa-miR-602_st −0.261698324 1.2 0.637781 0 hsa-miR-603_st −0.247980993 1.2 0.2261 0 hsa-miR-3065-5p_st −0.380875659 1.3 0.07396 0 hsa-miR-605_st 0.641019851 1.6 0.324367 0 hsa-miR-24_st −0.369924977 1.3 0.297219 0 hsa-miR-607_st −0.209988467 1.2 0.436253 0 hsa-miR-608_st −0.124432034 1.1 0.876296 0 hsa-miR-609_st 0.276648148 1.2 0.272527 0 hsa-miR-3196_st −0.587337228 1.5 0.040807 1 hsa-miR-26b_st −0.384026001 1.3 0.230171 0 hsa-miR-28-5p_st −0.55681306 1.5 0.130808 0 hsa-miR-613_st 0.40788491 1.3 0.183099 0 hsa-miR-338-3p_st −0.569116127 1.5 0.154786 0 hsa-miR-615-3p_st 0.260529206 1.2 0.504159 0 hsa-miR-454_st −0.189181024 1.1 0.387638 0 hsa-miR-616_st 0.138119199 1.1 0.300393 0 hsa-miR-151-5p_st −0.642988953 1.6 0.175205 0 hsa-miR-617_st 0.264122497 1.2 0.724963 0 hsa-miR-128_st −0.529815342 1.4 0.297195 0 hsa-miR-619_st 0.047502326 1.0 0.713212 0 hsa-miR-620_st −0.089209372 1.1 0.543616 0 hsa-miR-621_st −0.215152202 1.2 0.499079 0 hsa-let-7b_st −1.060342624 2.1 0.056396 0 hsa-miR-623_st −0.273425861 1.2 0.678655 0 hsa-miR-624_st −0.200274361 1.1 0.216688 0 hsa-miR-624-star_st −0.289634627 1.2 0.164177 0 hsa-miR-183_st −0.837843653 1.8 0.007493 1 hsa-miR-30b_st −0.602168176 1.5 0.112342 0 hsa-miR-626_st −0.013604155 1.0 0.504051 0 hsa-miR-627_st −0.26285602 1.2 0.146501 0 hsa-miR-628-3p_st 0.20617255 1.2 0.947019 0 hsa-miR-31-star_st 1.008221295 2.0 0.10216 0 hsa-miR-218-1-star_st 0.19138655 1.1 0.736088 0 hsa-miR-629-star_st 0.322071604 1.3 0.364393 0 hsa-miR-630_st 0.241920486 1.2 0.789739 0 hsa-miR-631_st 0.083701709 1.1 0.841573 0 hsa-miR-632_st 0.274281817 1.2 0.823026 0 hsa-miR-633_st −0.180421076 1.1 0.172827 0 hsa-miR-634_st 0.349201484 1.3 0.97113 0 hsa-miR-635_st 0.278910187 1.2 0.301707 0 hsa-miR-203_st −0.603288584 1.5 0.233348 0 hsa-miR-331-3p_st −1.132529983 2.2 0.025408 1 hsa-miR-125b_st −1.068651203 2.1 0.020043 1 hsa-let-7i_st −0.696906788 1.6 0.113879 0 hsa-miR-640_st 0.238622431 1.2 0.418223 0 hsa-miR-641_st 0.21807405 1.2 0.22334 0 hsa-miR-642_st −0.007190351 1.0 0.707111 0 hsa-miR-29b_st −0.224465445 1.2 0.223127 0 hsa-miR-122_st −0.252753055 1.2 0.79053 0 hsa-miR-645_st 0.323059312 1.3 0.131863 0 hsa-miR-646_st −0.004106416 1.0 0.608446 0 hsa-miR-647_st 0.002310483 1.0 0.923629 0 hsa-miR-648_st −0.083495466 1.1 0.940363 0 hsa-miR-649_st 0.484824104 1.4 0.156254 0 hsa-miR-182_st −0.551647558 1.5 0.057179 0 hsa-miR-651_st 0.075278806 1.1 0.623722 0 hsa-miR-652_st −0.392665599 1.3 0.291985 0 hsa-miR-653_st −0.030142309 1.0 0.431318 0 hsa-miR-654-3p_st 0.204752724 1.2 0.494421 0 hsa-miR-374b_st −0.389219932 1.3 0.308202 0 hsa-miR-130a_st −0.598663032 1.5 0.551599 0 hsa-miR-656_st −0.264392133 1.2 0.230117 0 hsa-miR-657_st 0.47885415 1.4 0.053702 0 hsa-miR-658_st −0.192581941 1.1 0.956642 0 hsa-miR-99b_st −0.828597088 1.8 0.055557 0 hsa-miR-660_st 0.070805656 1.1 0.755811 0 hsa-miR-661_st −0.020490661 1.0 0.948768 0 hsa-miR-30e-star_st −0.972613242 2.0 0.089056 0 hsa-miR-663_st −0.46072759 1.4 0.115409 0 hsa-miR-663b_st 0.09342398 1.1 0.555169 0 hsa-miR-664_st −0.231788933 1.2 0.250493 0 hsa-miR-664-star_st −0.070920199 1.1 0.286971 0 hsa-miR-30d_st −0.903114559 1.9 0.084351 0 hsa-miR-668_st 0.24126713 1.2 0.36126 0 hsa-miR-670_st 0.144836769 1.1 0.494357 0 hsa-miR-671-3p_st 0.487730943 1.4 0.05442 0 hsa-miR-671-5p_st −0.132564406 1.1 0.76555 0 hsa-miR-30a-star_st −1.014525825 2.0 0.194213 0 hsa-miR-675-star_st −0.241334067 1.2 0.8568 0 hsa-miR-148b_st −1.02335761 2.0 0.049828 1 hsa-miR-708_st −0.304189926 1.2 0.249819 0 hsa-miR-708-star_st −0.151683145 1.1 0.559369 0 hsa-miR-221-star_st 0.912773185 1.9 0.437778 0 hsa-let-7e_st −0.984814682 2.0 0.064014 0 hsa-miR-7-1-star_st 0.492212494 1.4 0.539457 0 hsa-miR-27b_st −0.502423556 1.4 0.184995 0 hsa-miR-34a_st −0.254499795 1.2 0.306261 0 hsa-miR-744_st −0.12949049 1.1 0.710007 0 hsa-miR-744-star_st 0.231780028 1.2 0.848745 0 hsa-miR-92b_st −0.987018168 2.0 0.038841 1 hsa-miR-759_st −0.040744078 1.0 0.712175 0 hsa-miR-760_st −0.208336436 1.2 0.927732 0 hsa-miR-92a_st −0.851482509 1.8 0.114543 0 hsa-miR-335_st −0.790414042 1.7 0.080158 0 hsa-miR-96_st −0.755514489 1.7 0.074444 0 hsa-miR-95_st −1.101331298 2.1 0.038983 1 hsa-miR-766_st 0.661310372 1.6 0.271489 0 hsa-miR-767-3p_st −0.011061369 1.0 0.875187 0 hsa-miR-767-5p_st −0.063625523 1.0 0.968104 0 hsa-miR-98_st −1.038759536 2.1 0.05849 0 hsa-miR-769-5p_st 0.206252202 1.2 0.562884 0 hsa-miR-770-5p_st 0.143722508 1.1 0.446095 0 hsa-miR-802_st −0.215800339 1.2 0.257675 0 hsa-miR-34b-star_st −0.335682604 1.3 0.229502 0 hsa-miR-581_st −0.005040097 1.0 0.776021 0 hsa-miR-181d_st −0.884990285 1.8 0.01641 1 hsa-miR-875-5p_st −0.248276935 1.2 0.621334 0 hsa-miR-876-3p_st 0.129940501 1.1 0.426214 0 hsa-miR-876-5p_st −0.420448704 1.3 0.118189 0 hsa-miR-151-3p_st −0.68021113 1.6 0.10884 0 hsa-miR-877-star_st 0.560690237 1.5 0.166084 0 hsa-miR-885-3p_st −0.415912648 1.3 0.459231 0 hsa-miR-200c_st −1.325095773 2.5 0.020261 1 hsa-miR-429_st −0.164948557 1.1 0.846295 0 hsa-miR-886-5p_st −0.316774919 1.2 0.406905 0 hsa-miR-224_st −0.726924302 1.7 0.02415 1 hsa-miR-888_st 0.276258796 1.2 0.189061 0 hsa-miR-4321_st −0.007044479 1.0 0.969431 0 hsa-miR-889_st −0.05918416 1.0 0.852076 0 hsa-miR-181b_st −0.906378432 1.9 0.006273 1 hsa-miR-891a_st 0.199083711 1.1 0.928248 0 hsa-miR-891b_st −0.453899811 1.4 0.077047 0 hsa-miR-892a_st 0.220883626 1.2 0.923924 0 hsa-miR-892b_st 0.398921801 1.3 0.411778 0 hsa-miR-9_st −0.151862278 1.1 0.807469 0 hsa-miR-222_st 0.395156873 1.3 0.861048 0 hsa-miR-141_st −0.924987374 1.9 0.038222 1 hsa-miR-221_st 0.301407799 1.2 0.801187 0 hsa-miR-924_st 0.260584211 1.2 0.203996 0 hsa-miR-181a_st −0.98250849 2.0 0.011286 1 hsa-miR-181c_st −0.971885561 2.0 0.028918 1 hsa-miR-4324_st −1.277867506 2.4 0.020845 1 hsa-miR-125a-5p_st −1.489619943 2.8 0.005292 1 hsa-miR-92b-star_st −0.30561747 1.2 0.267503 0 hsa-miR-3195_st −0.084028146 1.1 0.970109 0 hsa-miR-3137_st −0.067024711 1.0 0.933037 0 hsa-miR-934_st −0.101763082 1.1 0.694268 0 hsa-miR-935_st −0.27814374 1.2 0.850873 0 hsa-miR-551b_st −0.118639181 1.1 0.335244 0 hsa-miR-937_st 0.272682005 1.2 0.6105 0 hsa-miR-938_st −0.006282307 1.0 0.972352 0 hsa-miR-939_st −0.168395898 1.1 0.747793 0 hsa-miR-7-2-star_st −1.572034886 3.0 0.003288 1 hsa-miR-146b-5p_st 1.926314015 3.8 0.00917 1 hsa-miR-941_st −0.127016526 1.1 0.727922 0 hsa-miR-942_st −0.016748552 1.0 0.736351 0 hsa-miR-200a_st −1.022937616 2.0 0.393213 0 hsa-miR-944_st −0.129469014 1.1 0.481936 0 hsa-miR-7_st −2.668505438 6.4 0.005751 1 hsa-miR-375_st 0.070149041 1.0 0.227761 0 hsa-miR-96-star_st −0.132706904 1.1 0.37858 0 hsa-miR-424_st −0.471546914 1.4 0.060324 0 hsa-miR-181a-2-star_st −0.427668902 1.3 0.507989 0 hsa-miR-200b_st −1.477637109 2.8 0.170971 0 hsa-miR-146b-3p_st 0.069042454 1.0 0.547276 0 hsa-miR-99b-star_st 0.011824216 1.0 0.981221 0 hsa-miR-9-star_st 0.66127744 1.6 0.052915 0 Fold change Log2Diff (Hash (Hash vs Ttest (Hash vs Sample Name vs Malignant) Malignant) Malignant p < 0.05 hsa-miR-150_st 1.875714 3.7 0.044579 1 hsa-let-7a-2-star_st −0.31551 1.2 0.301611 0 hsa-let-7a-star_st −0.36659 1.3 0.265805 0 hsa-miR-513b_st 1.508771 2.8 0.00012 1 hsa-let-7b-star_st −0.44157 1.4 0.1364 0 hsa-miR-593-star_st 1.423566 2.7 0.0021 1 hsa-let-7c-star_st 0.089854 1.1 0.68784 0 hsa-miR-516a-5p_st 1.412039 2.7 0.009506 1 hsa-miR-142-5p_st 1.612655 3.1 0.088518 0 hsa-miR-650_st 1.332113 2.5 0.001228 1 hsa-miR-513c_st 1.315059 2.5 0.005088 1 hsa-miR-761_st 1.17578 2.3 0.006414 1 hsa-let-7f-1-star_st 0.210488 1.2 0.228788 0 hsa-miR-513a-5p_st 1.172649 2.3 0.000182 1 hsa-miR-654-5p_st 1.123106 2.2 0.007934 1 hsa-let-7g-star_st −0.03205 1.0 0.886417 0 hsa-miR-3163_st 1.117019 2.2 0.001389 1 hsa-let-7i-star_st −0.83393 1.8 0.090286 0 hsa-miR-3165_st 1.110869 2.2 0.005339 1 hsa-miR-3194_st 1.105484 2.2 1.27E−05 1 hsa-miR-100-star_st −0.28409 1.2 0.245667 0 hsa-miR-4251_st 1.105055 2.2 0.002238 1 hsa-miR-101-star_st −0.34338 1.3 0.276063 0 hsa-miR-922_st 1.102917 2.1 0.004213 1 hsa-miR-103-2-star_st −0.04052 1.0 0.883122 0 hsa-miR-155_st 1.026916 2.0 0.123084 0 hsa-miR-105_st −0.01722 1.0 0.955109 0 hsa-miR-127-5p_st 1.096208 2.1 0.004424 1 hsa-miR-1286_st 1.078866 2.1 0.000741 1 hsa-miR-106a-star_st −0.26819 1.2 0.373393 0 hsa-miR-890_st 1.061787 2.1 9.37E−07 1 hsa-miR-3126-5p_st 1.050997 2.1 0.000607 1 hsa-miR-489_st 1.047216 2.1 0.000714 1 hsa-miR-10a_st −0.94081 1.9 0.155039 0 hsa-miR-10a-star_st 0.157045 1.1 0.715294 0 hsa-miR-10b_st −1.26782 2.4 0.151474 0 hsa-miR-10b-star_st 0.127257 1.1 0.774825 0 hsa-miR-1178_st 0.273575 1.2 0.324821 0 hsa-miR-1179_st −0.2557 1.2 0.234035 0 hsa-miR-1180_st 0.11037 1.1 0.595952 0 hsa-miR-1181_st 0.849947 1.8 0.072693 0 hsa-miR-3138_st 1.042224 2.1 0.001262 1 hsa-miR-220c_st 1.040993 2.1 0.030176 1 hsa-miR-510_st 1.024315 2.0 0.005425 1 hsa-miR-1185_st −0.03782 1.0 0.909432 0 hsa-miR-1193_st 0.195471 1.1 0.25975 0 hsa-miR-1197_st −0.30152 1.2 0.078413 0 hsa-miR-1200_st 0.204895 1.2 0.378627 0 hsa-miR-1201_st −0.70374 1.6 0.330666 0 hsa-miR-1202_st 0.452039 1.4 0.080756 0 hsa-miR-30c-1-star_st 1.010031 2.0 0.000171 1 hsa-miR-1204_st 0.496589 1.4 0.145406 0 hsa-miR-1205_st 0.493938 1.4 0.211099 0 hsa-miR-1206_st −0.13518 1.1 0.677162 0 hsa-miR-1207-3p_st 0.027025 1.0 0.913751 0 hsa-miR-1207-5p_st 0.217031 1.2 0.35373 0 hsa-miR-1208_st 0.615208 1.5 0.064249 0 hsa-miR-622_st 1.002602 2.0 0.000496 1 hsa-miR-1224-3p_st 0.18884 1.1 0.44359 0 hsa-miR-2116_st 0.997903 2.0 0.043086 1 hsa-miR-1225-3p_st 0.275144 1.2 0.365143 0 hsa-miR-1225-5p_st 0.303019 1.2 0.165493 0 hsa-miR-1226_st 0.232875 1.2 0.572675 0 hsa-miR-30b-star_st 0.99662 2.0 0.000239 1 hsa-miR-1227_st 0.130739 1.1 0.722961 0 hsa-miR-1295_st 0.965171 2.0 0.037721 1 hsa-miR-1228-star_st −0.10986 1.1 0.684339 0 hsa-miR-20b_st −1.17916 2.3 0.066541 0 hsa-miR-122-star_st −0.21621 1.2 0.400662 0 hsa-miR-1231_st 0.176725 1.1 0.2744 0 hsa-miR-1233_st 0.309807 1.2 0.427353 0 hsa-miR-524-5p_st 0.962215 1.9 0.034037 1 hsa-miR-1236_st 0.392062 1.3 0.346635 0 hsa-miR-873_st 0.960328 1.9 0.023024 1 hsa-miR-1238_st 0.418415 1.3 0.089886 0 hsa-miR-124_st 0.301845 1.2 0.208797 0 hsa-miR-1243_st 0.216208 1.2 0.292643 0 hsa-miR-1244_st 0.273916 1.2 0.286377 0 hsa-miR-1245_st 0.014963 1.0 0.927859 0 hsa-miR-3122_st 0.956415 1.9 0.001031 1 hsa-miR-134_st 0.951455 1.9 0.008063 1 hsa-miR-1248_st 0.341599 1.3 0.525042 0 hsa-miR-146a_st −0.10185 1.1 0.886781 0 hsa-miR-124-star_st 0.188331 1.1 0.549282 0 hsa-miR-1250_st 0.477374 1.4 0.062697 0 hsa-miR-764_st 0.944549 1.9 0.029763 1 hsa-miR-1252_st −0.36086 1.3 0.0759 0 hsa-miR-223_st 0.345189 1.3 0.536099 0 hsa-miR-34c-3p_st 0.931121 1.9 0.027117 1 hsa-miR-1255a_st 0.544442 1.5 0.250369 0 hsa-miR-1255b_st 0.421079 1.3 0.225408 0 hsa-miR-1256_st −0.09835 1.1 0.765266 0 hsa-miR-1257_st 0.465829 1.4 0.244453 0 hsa-miR-199b-5p_st 1.498449 2.8 0.05722 0 hsa-miR-1259_st −0.58277 1.5 0.102356 0 hsa-miR-492_st 0.921568 1.9 0.004193 1 hsa-miR-3132_st 0.91529 1.9 0.006633 1 hsa-miR-516b_st 0.906583 1.9 0.01613 1 hsa-miR-4294_st 0.893861 1.9 0.011225 1 hsa-miR-125b-2-star_st 0.767035 1.7 0.076332 0 hsa-miR-126_st −0.82732 1.8 0.170127 0 hsa-miR-198_st 0.889231 1.9 0.001101 1 hsa-miR-3191_st 0.886404 1.8 0.004907 1 hsa-miR-1261_st 0.831512 1.8 0.085713 0 hsa-miR-1262_st 0.393495 1.3 0.364087 0 hsa-miR-1263_st −0.12747 1.1 0.552383 0 hsa-miR-1264_st 0.0838 1.1 0.688254 0 hsa-miR-1265_st −0.13493 1.1 0.554693 0 hsa-miR-2114-star_st 0.884951 1.8 9.46E−05 1 hsa-miR-1267_st 0.227677 1.2 0.357215 0 hsa-miR-1268_st 0.194238 1.1 0.49276 0 hsa-miR-1269_st 0.735073 1.7 0.096024 0 hsa-miR-509-5p_st 0.884033 1.8 0.022491 1 hsa-miR-1270_st 0.222275 1.2 0.288086 0 hsa-miR-1271_st 0.47179 1.4 0.060323 0 hsa-miR-4303_st 0.881737 1.8 0.016852 1 hsa-miR-1273_st 0.600535 1.5 0.06331 0 hsa-miR-583_st 0.877605 1.8 0.004025 1 hsa-miR-1273d_st 0.216905 1.2 0.549029 0 hsa-miR-127-3p_st −0.10559 1.1 0.848858 0 hsa-miR-522-star_st 0.873604 1.8 0.027286 1 hsa-miR-214-star_st 0.642526 1.6 0.202705 0 hsa-miR-184_st 0.871629 1.8 0.00286 1 hsa-miR-614_st 0.857975 1.8 0.04195 1 hsa-miR-526b_st 0.857611 1.8 0.04803 1 hsa-miR-1277_st −0.35282 1.3 0.280035 0 hsa-miR-1278_st −0.35407 1.3 0.071881 0 hsa-miR-1279_st −0.07028 1.0 0.771238 0 hsa-miR-409-3p_st 0.856455 1.8 0.007228 1 hsa-miR-199a-5p_st 0.427177 1.3 0.4469 0 hsa-miR-1281_st 0.591077 1.5 0.169969 0 hsa-miR-1282_st 0.687995 1.6 0.098686 0 hsa-miR-33b-star_st 0.856443 1.8 0.001443 1 hsa-miR-1284_st 0.527601 1.4 0.275269 0 hsa-miR-1253_st 0.855604 1.8 0.021967 1 hsa-miR-584_st 0.85471 1.8 0.012501 1 hsa-miR-1287_st 0.022292 1.0 0.933218 0 hsa-miR-15a_st −1.44424 2.7 0.062589 0 hsa-miR-1289_st 0.136444 1.1 0.728477 0 hsa-miR-1290_st −0.08536 1.1 0.70507 0 hsa-miR-2117_st 0.853282 1.8 0.006 1 hsa-miR-1292_st 0.567588 1.5 0.060194 0 hsa-miR-1293_st 0.4512 1.4 0.082812 0 hsa-miR-129-3p_st −0.33341 1.3 0.230296 0 hsa-miR-520d-5p_st 0.844618 1.8 0.01104 1 hsa-miR-526a_st 0.830069 1.8 0.000269 1 hsa-miR-129-5p_st 0.485606 1.4 0.145359 0 hsa-miR-1254_st 0.822758 1.8 0.018758 1 hsa-miR-1297_st −0.04232 1.0 0.899938 0 hsa-miR-1298_st 0.488409 1.4 0.260542 0 hsa-miR-1299_st 0.487699 1.4 0.26277 0 hsa-miR-129-star_st −0.10101 1.1 0.687767 0 hsa-miR-1301_st 0.252078 1.2 0.280775 0 hsa-miR-19b_st −1.05119 2.1 0.08905 0 hsa-miR-1303_st 0.250626 1.2 0.369998 0 hsa-miR-1304_st 0.305952 1.2 0.427725 0 hsa-miR-1305_st 0.400742 1.3 0.44183 0 hsa-miR-550_st 0.822385 1.8 0.001078 1 hsa-miR-1307_st 0.224586 1.2 0.406932 0 hsa-miR-1308_st −0.34814 1.3 0.152621 0 hsa-miR-4291_st −0.09111 1.1 0.602121 0 hsa-miR-130a-star_st 0.031171 1.0 0.871897 0 hsa-miR-130b_st −0.34378 1.3 0.206141 0 hsa-miR-130b-star_st −0.14432 1.1 0.543456 0 hsa-miR-921_st 0.821315 1.8 0.008626 1 hsa-miR-520a-5p_st 0.818193 1.8 0.012442 1 hsa-miR-711_st 0.817404 1.8 0.004764 1 hsa-miR-1323_st 0.674252 1.6 0.067574 0 hsa-miR-1324_st −0.22954 1.2 0.37862 0 hsa-miR-490-3p_st 0.816985 1.8 0.038855 1 hsa-miR-718_st 0.809921 1.8 0.017676 1 hsa-miR-133b_st −0.87168 1.8 0.075142 0 hsa-miR-431-star_st 0.807161 1.7 0.00016 1 hsa-miR-552_st 0.798145 1.7 0.047519 1 hsa-miR-28-3p_st −0.68249 1.6 0.14528 0 hsa-miR-4265_st 0.795713 1.7 0.009225 1 hsa-miR-643_st 0.791608 1.7 0.010439 1 hsa-miR-136_st −0.284 1.2 0.33253 0 hsa-miR-136-star_st −0.1462 1.1 0.566334 0 hsa-miR-137_st −0.29411 1.2 0.199558 0 hsa-miR-138_st −0.86137 1.8 0.158401 0 hsa-miR-138-1-star_st 0.327307 1.3 0.268606 0 hsa-miR-138-2-star_st −0.16997 1.1 0.26209 0 hsa-miR-139-3p_st 0.378296 1.3 0.240417 0 hsa-miR-139-5p_st −0.84982 1.8 0.269061 0 hsa-miR-140-3p_st −0.09719 1.1 0.735093 0 hsa-miR-140-5p_st −0.30577 1.2 0.644907 0 hsa-miR-381_st 0.790236 1.7 0.043949 1 hsa-miR-141-star_st −0.53573 1.4 0.08319 0 hsa-miR-17-star_st −0.65299 1.6 0.063488 0 hsa-miR-4300_st 0.786614 1.7 0.013676 1 hsa-miR-143_st −0.74859 1.7 0.205791 0 hsa-miR-143-star_st −0.95118 1.9 0.055095 0 hsa-miR-144_st −0.26459 1.2 0.295062 0 hsa-miR-3198_st 0.786366 1.7 0.000418 1 hsa-miR-145_st −0.9402 1.9 0.128782 0 hsa-miR-145-star_st −0.69784 1.6 0.191585 0 hsa-miR-1468_st 0.213869 1.2 0.658863 0 hsa-miR-1469_st −0.40619 1.3 0.192709 0 hsa-miR-1973_st 0.77824 1.7 0.036356 1 hsa-miR-3154_st 0.774015 1.7 0.01305 1 hsa-miR-148a-star_st 0.772736 1.7 0.0069 1 hsa-miR-92a-1-star_st 0.772103 1.7 0.036102 1 hsa-miR-147_st 0.078408 1.1 0.729668 0 hsa-miR-194-star_st 0.772062 1.7 0.041214 1 hsa-miR-1471_st 0.955038 1.9 0.065698 0 hsa-miR-147b_st 0.196952 1.1 0.331561 0 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hsa-miR-16-1-star_st −0.04953 1.0 0.806199 0 hsa-miR-16-2-star_st −0.18057 1.1 0.621224 0 hsa-miR-490-5p_st 0.733163 1.7 0.019749 1 hsa-miR-19a_st −0.73853 1.7 0.258325 0 hsa-miR-3192_st 0.725774 1.7 0.00695 1 hsa-miR-3155_st 0.724445 1.7 0.003758 1 hsa-miR-187-star_st 0.706712 1.6 0.009081 1 hsa-miR-16_st −1.03856 2.1 0.050954 0 hsa-miR-936_st 0.702428 1.6 0.045123 1 hsa-miR-181c-star_st 0.331128 1.3 0.204591 0 hsa-miR-379_st 0.701926 1.6 0.003104 1 hsa-miR-370_st 0.694164 1.6 0.041315 1 hsa-miR-541_st 0.69062 1.6 0.007675 1 hsa-miR-518c-star_st 0.689772 1.6 0.03014 1 hsa-miR-487b_st −1.10699 2.2 0.08351 0 hsa-miR-182-star_st −0.39898 1.3 0.092095 0 hsa-miR-3121_st 0.678557 1.6 0.039293 1 hsa-miR-3190-5p_st 0.671926 1.6 0.002554 1 hsa-miR-1203_st 0.671562 1.6 0.007305 1 hsa-miR-185_st −0.43336 1.4 0.116931 0 hsa-miR-185-star_st 0.459497 1.4 0.114769 0 hsa-miR-4317_st 0.670075 1.6 0.011878 1 hsa-miR-186-star_st 0.034947 1.0 0.893137 0 hsa-miR-187_st 0.128295 1.1 0.685571 0 hsa-miR-4257_st 0.668313 1.6 0.030443 1 hsa-miR-188-3p_st 0.1315 1.1 0.716928 0 hsa-miR-1184_st 0.665635 1.6 0.037958 1 hsa-miR-18a_st −0.28267 1.2 0.164215 0 hsa-miR-18a-star_st 0.342808 1.3 0.378501 0 hsa-miR-3140_st 0.747055 1.7 0.061304 0 hsa-miR-18b-star_st 0.216133 1.2 0.557616 0 hsa-miR-190_st −0.21498 1.2 0.439422 0 hsa-miR-601_st 0.660332 1.6 0.005155 1 hsa-miR-1909_st 0.192208 1.1 0.313762 0 hsa-miR-342-5p_st 0.042705 1.0 0.913482 0 hsa-miR-575_st 0.654796 1.6 0.008434 1 hsa-miR-885-5p_st 0.648065 1.6 0.000298 1 hsa-miR-300_st 0.646007 1.6 0.027217 1 hsa-miR-1911_st 0.301352 1.2 0.451263 0 hsa-miR-1911-star_st 0.556923 1.5 0.059267 0 hsa-miR-1912_st 0.166966 1.1 0.506126 0 hsa-miR-4266_st 0.644002 1.6 0.000275 1 hsa-miR-1914_st 0.018837 1.0 0.944043 0 hsa-miR-3190-3p_st 0.640988 1.6 0.00925 1 hsa-miR-618_st 0.488546 1.4 0.083241 0 hsa-miR-1276_st 0.640921 1.6 0.04047 1 hsa-miR-191-star_st 0.331398 1.3 0.296017 0 hsa-miR-1258_st 0.639865 1.6 0.006649 1 hsa-miR-192-star_st −0.2641 1.2 0.284911 0 hsa-miR-193a-3p_st −0.32757 1.3 0.342606 0 hsa-miR-193a-5p_st 0.183923 1.1 0.326434 0 hsa-miR-3157_st 0.638836 1.6 0.026165 1 hsa-miR-193b-star_st 0.331651 1.3 0.159696 0 hsa-miR-194_st −1.73238 3.3 0.062446 0 hsa-miR-4307_st 0.638766 1.6 0.01805 1 hsa-miR-195_st −0.80453 1.7 0.084874 0 hsa-miR-610_st 0.638641 1.6 0.028997 1 hsa-miR-196a_st 0.039663 1.0 0.93635 0 hsa-miR-196a-star_st 0.411119 1.3 0.270488 0 hsa-miR-196b_st −0.23934 1.2 0.237931 0 hsa-miR-196b-star_st 0.372442 1.3 0.052483 0 hsa-let-7f-2-star_st 0.318026 1.2 0.182124 0 hsa-miR-1972_st 0.380764 1.3 0.272945 0 hsa-miR-3184_st 0.637447 1.6 0.008355 1 hsa-miR-523-star_st 0.634662 1.6 0.014225 1 hsa-miR-1976_st 0.628612 1.5 0.13413 0 hsa-miR-625-star_st 0.268834 1.2 0.093935 0 hsa-miR-587_st 0.624556 1.5 0.026177 1 hsa-miR-199a-3p_st 0.292851 1.2 0.612147 0 hsa-miR-1910_st 0.609315 1.5 0.041325 1 hsa-miR-199b-3p_st 0.055928 1.0 0.924762 0 hsa-miR-639_st 0.60737 1.5 0.048683 1 hsa-miR-1909-star_st 0.606356 1.5 1.25E−06 1 hsa-miR-19a-star_st −0.27865 1.2 0.289921 0 hsa-miR-29c-star_st −1.6614 3.2 0.06327 0 hsa-miR-940_st 0.606168 1.5 0.042061 1 hsa-miR-19b-2-star_st −4.6E−05 1.0 0.999792 0 hsa-miR-4269_st 0.598367 1.5 0.012089 1 hsa-miR-200a-star_st −0.18332 1.1 0.477612 0 hsa-miR-1182_st 0.597921 1.5 0.016922 1 hsa-miR-518f-star_st 0.595153 1.5 1.56E−05 1 hsa-miR-92a-2-star_st 0.590639 1.5 0.011594 1 hsa-miR-200c-star_st −0.24667 1.2 0.477193 0 hsa-miR-202_st 0.641966 1.6 0.128031 0 hsa-miR-202-star_st −0.48909 1.4 0.150944 0 hsa-miR-1914-star_st 0.589626 1.5 0.005491 1 hsa-miR-204_st 0.102403 1.1 0.929327 0 hsa-miR-665_st 0.588756 1.5 0.005496 1 hsa-miR-2052_st −0.40226 1.3 0.188069 0 hsa-miR-2053_st −0.36242 1.3 0.300434 0 hsa-miR-2054_st −0.40666 1.3 0.439771 0 hsa-miR-205-star_st −0.08515 1.1 0.784191 0 hsa-miR-206_st 0.355367 1.3 0.320102 0 hsa-miR-208a_st −0.06721 1.0 0.678773 0 hsa-miR-208b_st −0.09144 1.1 0.568574 0 hsa-miR-18b_st −0.05011 1.0 0.766176 0 hsa-miR-20a-star_st −0.26139 1.2 0.701305 0 hsa-miR-3181_st 0.587489 1.5 0.001646 1 hsa-miR-615-5p_st 0.576959 1.5 0.005529 1 hsa-miR-4259_st 0.571165 1.5 0.042946 1 hsa-miR-210_st 0.411214 1.3 0.150148 0 hsa-miR-211_st 0.498095 1.4 0.26268 0 hsa-miR-887_st 0.561505 1.5 0.037889 1 hsa-miR-2113_st 0.697154 1.6 0.136226 0 hsa-miR-2114_st 0.411317 1.3 0.318544 0 hsa-miR-943_st 0.559797 1.5 0.047085 1 hsa-miR-2115_st −0.2913 1.2 0.21671 0 hsa-miR-2115-star_st 0.154402 1.1 0.639485 0 hsa-miR-183-star_st 0.555936 1.5 0.011356 1 hsa-miR-2116-star_st 0.31883 1.2 0.089494 0 hsa-miR-920_st 0.555817 1.5 0.023831 1 hsa-miR-212_st −0.05172 1.0 0.772202 0 hsa-miR-214_st 0.38808 1.3 0.175459 0 hsa-miR-1825_st 0.555623 1.5 0.043279 1 hsa-miR-215_st 0.214687 1.2 0.618197 0 hsa-miR-216a_st 0.119691 1.1 0.691055 0 hsa-miR-195-star_st 0.555205 1.5 0.039797 1 hsa-miR-217_st −0.3559 1.3 0.098919 0 hsa-miR-23a-star_st 0.553064 1.5 0.047762 1 hsa-miR-25-star_st 0.552629 1.5 0.006373 1 hsa-miR-218-2-star_st 0.337983 1.3 0.14847 0 hsa-miR-1273c_st 0.550118 1.5 3.29E−05 1 hsa-miR-219-2-3p_st 0.391086 1.3 0.136592 0 hsa-miR-637_st 0.548247 1.5 0.025514 1 hsa-miR-21-star_st 0.004585 1.0 0.985108 0 hsa-miR-22_st −1.30177 2.5 0.086492 0 hsa-miR-220a_st −0.30806 1.2 0.2524 0 hsa-miR-220b_st −0.3178 1.2 0.441672 0 hsa-miR-219-1-3p_st 0.547109 1.5 0.015326 1 hsa-miR-4316_st 0.545925 1.5 0.028937 1 hsa-miR-877_st 0.544226 1.5 0.024713 1 hsa-miR-636_st 0.542077 1.5 0.001797 1 hsa-miR-3177_st 0.54161 1.5 0.047178 1 hsa-miR-1249_st 0.363863 1.3 0.065578 0 hsa-miR-223-star_st −0.0065 1.0 0.977432 0 hsa-miR-1224-5p_st 0.540511 1.5 0.023547 1 hsa-miR-564_st 0.537952 1.5 0.017022 1 hsa-miR-2276_st 0.641524 1.6 0.05684 0 hsa-miR-2277_st 0.246085 1.2 0.05544 0 hsa-miR-2278_st 0.282229 1.2 0.380202 0 hsa-miR-22-star_st −1.5792 3.0 0.07011 0 hsa-miR-2355_st 0.332667 1.3 0.334732 0 hsa-miR-769-3p_st 0.528291 1.4 0.024697 1 hsa-miR-1913_st 0.524346 1.4 0.016332 1 hsa-miR-1237_st 0.523439 1.4 0.010516 1 hsa-miR-1275_st 0.519394 1.4 0.011609 1 hsa-miR-30a_st −1.59389 3.0 0.053482 0 hsa-miR-20b-star_st 0.516908 1.4 0.001255 1 hsa-miR-24-2-star_st −0.28328 1.2 0.49321 0 hsa-miR-3173_st 0.513023 1.4 0.005621 1 hsa-miR-3148_st 0.504822 1.4 0.017042 1 hsa-miR-4271_st 0.503092 1.4 0.016961 1 hsa-miR-659_st 0.502228 1.4 0.037237 1 hsa-miR-26a-2-star_st −0.53467 1.4 0.100688 0 hsa-miR-1228_st 0.492951 1.4 0.004204 1 hsa-miR-26b-star_st −0.91139 1.9 0.052335 0 hsa-miR-3174_st 0.488054 1.4 0.028285 1 hsa-miR-27a-star_st 0.365267 1.3 0.398611 0 hsa-miR-1285_st 0.48656 1.4 0.0276 1 hsa-miR-483-5p_st 0.484088 1.4 0.019715 1 hsa-miR-1306_st 0.47498 1.4 0.018178 1 hsa-miR-431_st −0.13576 1.1 0.480103 0 hsa-miR-765_st 0.469709 1.4 0.015836 1 hsa-miR-2909_st −0.41055 1.3 0.070524 0 hsa-miR-296-3p_st 0.454547 1.4 0.172491 0 hsa-miR-296-5p_st 0.030755 1.0 0.931089 0 hsa-miR-297_st 0.59143 1.5 0.076305 0 hsa-miR-323b-5p_st 0.467628 1.4 0.02754 1 hsa-miR-299-3p_st 0.527648 1.4 0.143613 0 hsa-miR-299-5p_st −0.3216 1.2 0.157633 0 hsa-miR-487a_st −0.24674 1.2 0.481717 0 hsa-miR-29a-star_st −0.03674 1.0 0.800392 0 hsa-miR-625_st 0.465514 1.4 0.001444 1 hsa-miR-611_st 0.463188 1.4 0.028433 1 hsa-miR-3186-3p_st 0.13237 1.1 0.464634 0 hsa-miR-1294_st 0.45925 1.4 0.000207 1 hsa-miR-3147_st 0.453551 1.4 0.033619 1 hsa-miR-4285_st 0.452341 1.4 0.005763 1 hsa-miR-125a-3p_st 0.449103 1.4 0.045559 1 hsa-miR-301b_st −0.25304 1.2 0.302497 0 hsa-miR-302a_st −0.12894 1.1 0.596222 0 hsa-miR-518e-star_st 0.38764 1.3 0.105122 0 hsa-miR-302b_st −0.52908 1.4 0.273314 0 hsa-miR-302b-star_st −0.04225 1.0 0.784851 0 hsa-miR-302c_st 0.199064 1.1 0.488595 0 hsa-miR-302c-star_st 0.29394 1.2 0.280373 0 hsa-miR-302d_st −0.06298 1.0 0.788555 0 hsa-miR-302d-star_st 0.175419 1.1 0.365582 0 hsa-miR-302e_st 0.214081 1.2 0.483859 0 hsa-miR-302f_st −0.30715 1.2 0.116968 0 hsa-miR-3065-3p_st 0.445283 1.4 0.381861 0 hsa-miR-3130-5p_st 0.443525 1.4 0.006041 1 hsa-miR-3074_st 0.361137 1.3 0.185526 0 hsa-miR-1226-star_st 0.430801 1.3 0.011928 1 hsa-miR-3180-5p_st 0.422603 1.3 0.004494 1 hsa-miR-1229_st −0.26277 1.2 0.265342 0 hsa-miR-1272_st 0.404677 1.3 0.025278 1 hsa-miR-30c_st −1.52878 2.9 0.055533 0 hsa-miR-675_st 0.403807 1.3 0.042038 1 hsa-miR-30c-2-star_st 0.193289 1.1 0.551076 0 hsa-miR-1827_st −0.25393 1.2 0.286345 0 hsa-miR-30d-star_st −0.35176 1.3 0.335497 0 hsa-miR-30e_st −1.35054 2.6 0.072977 0 hsa-miR-1915-star_st 0.394113 1.3 0.030865 1 hsa-miR-1322_st 0.284062 1.2 0.059485 0 hsa-miR-3115_st −0.1998 1.1 0.521976 0 hsa-miR-3116_st 0.710094 1.6 0.148728 0 hsa-miR-3117_st 0.098397 1.1 0.674454 0 hsa-miR-3118_st −0.38242 1.3 0.200637 0 hsa-miR-519b-5p_st 0.29833 1.2 0.124851 0 hsa-miR-3120_st 0.617442 1.5 0.161642 0 hsa-miR-520d-3p_st 0.391973 1.3 0.018418 1 hsa-miR-326_st 0.13226 1.1 0.709207 0 hsa-miR-3123_st −0.14352 1.1 0.647179 0 hsa-miR-3124_st 0.345081 1.3 0.100198 0 hsa-miR-3125_st 0.428808 1.3 0.073487 0 hsa-miR-3126-3p_st 0.297163 1.2 0.325054 0 hsa-miR-1296_st 0.383213 1.3 0.031933 1 hsa-miR-3127_st 0.573278 1.5 0.158541 0 hsa-miR-3128_st −0.04611 1.0 0.743651 0 hsa-miR-3129_st 0.032291 1.0 0.831513 0 hsa-miR-3130-3p_st 0.672925 1.6 0.066666 0 hsa-miR-105-star_st 0.375449 1.3 0.033706 1 hsa-miR-3131_st 0.465825 1.4 0.107269 0 hsa-miR-4255_st 0.365234 1.3 0.003793 1 hsa-miR-3133_st −0.0711 1.1 0.814963 0 hsa-miR-3134_st 0.238194 1.2 0.249768 0 hsa-miR-3135_st 0.570109 1.5 0.19266 0 hsa-miR-3136_st 0.239942 1.2 0.379858 0 hsa-miR-19b-1-star_st −0.34712 1.3 0.091626 0 hsa-miR-1247_st 0.360962 1.3 0.048596 1 hsa-miR-3139_st 0.0296 1.0 0.814292 0 hsa-miR-596_st 0.34814 1.3 0.010696 1 hsa-miR-3141_st 0.179654 1.1 0.428193 0 hsa-miR-3142_st −0.39884 1.3 0.275076 0 hsa-miR-1302_st −0.03991 1.0 0.828261 0 hsa-miR-3144-3p_st 0.493278 1.4 0.335096 0 hsa-miR-3144-5p_st 0.654076 1.6 0.241783 0 hsa-miR-3145_st 0.102562 1.1 0.775374 0 hsa-miR-3146_st 0.354102 1.3 0.29619 0 hsa-miR-346_st 0.340806 1.3 0.015166 1 hsa-miR-4256_st 0.337694 1.3 0.034184 1 hsa-miR-3149_st 0.174477 1.1 0.542794 0 hsa-miR-3150_st 0.328084 1.3 0.245074 0 hsa-miR-3151_st 0.431145 1.3 0.061934 0 hsa-miR-1470_st 0.2901 1.2 0.04659 1 hsa-miR-3153_st 0.608063 1.5 0.071465 0 hsa-miR-514_st −0.32643 1.3 0.018998 1 hsa-miR-3175_st 0.061548 1.0 0.458648 0 hsa-miR-3156_st 0.039395 1.0 0.827998 0 hsa-miR-504_st −0.38157 1.3 0.039504 1 hsa-miR-3158_st 0.337955 1.3 0.324134 0 hsa-miR-3159_st 0.375088 1.3 0.193 0 hsa-miR-3160_st 0.52557 1.4 0.112793 0 hsa-miR-3161_st 0.484887 1.4 0.05837 0 hsa-miR-3162_st 0.398542 1.3 0.081205 0 hsa-miR-1234_st 0.140992 1.1 0.339242 0 hsa-miR-3164_st 0.981603 2.0 0.061762 0 hsa-miR-516b-star_st −0.40417 1.3 0.012774 1 hsa-miR-3166_st −0.29905 1.2 0.292792 0 hsa-miR-4327_st 0.435291 1.4 0.072588 0 hsa-miR-3168_st −0.34 1.3 0.105811 0 hsa-miR-3169_st 0.243496 1.2 0.162131 0 hsa-miR-3170_st 0.654847 1.6 0.066308 0 hsa-miR-3171_st −0.24959 1.2 0.316457 0 hsa-miR-3172_st −0.72679 1.7 0.090613 0 hsa-miR-374b-star_st −0.42979 1.3 0.019 1 hsa-miR-34c-5p_st −0.45892 1.4 0.036567 1 hsa-miR-758_st −0.46021 1.4 0.037008 1 hsa-miR-3176_st −0.34295 1.3 0.178088 0 hsa-miR-606_st −0.46641 1.4 0.001349 1 hsa-miR-3178_st 0.042974 1.0 0.875195 0 hsa-miR-3179_st 0.214452 1.2 0.674335 0 hsa-miR-3180-3p_st 0.100646 1.1 0.626711 0 hsa-miR-597_st −0.48867 1.4 0.00307 1 hsa-miR-148b-star_st −0.49185 1.4 0.000147 1 hsa-miR-3182_st 0.050587 1.0 0.872925 0 hsa-miR-3183_st 0.475639 1.4 0.101116 0 hsa-miR-144-star_st −0.5221 1.4 0.020296 1 hsa-miR-3185_st 0.057419 1.0 0.814649 0 hsa-miR-4270_st 0.101124 1.1 0.709515 0 hsa-miR-3186-5p_st 0.457756 1.4 0.257013 0 hsa-miR-3187_st 0.431073 1.3 0.076258 0 hsa-miR-3188_st 0.389334 1.3 0.154408 0 hsa-miR-3189_st 0.563296 1.5 0.144408 0 hsa-miR-548b-3p_st −0.52461 1.4 0.046675 1 hsa-miR-99a-star_st −0.53393 1.4 0.032903 1 hsa-miR-376a-star_st −0.53981 1.5 0.039221 1 hsa-miR-216b_st −0.54189 1.5 0.048686 1 hsa-miR-3193_st 0.214962 1.2 0.385821 0 hsa-miR-548v_st −0.54296 1.5 0.000842 1 hsa-miR-26a-1-star_st 0.219347 1.2 0.447431 0 hsa-miR-1291_st 0.050424 1.0 0.832165 0 hsa-miR-3197_st 0.296022 1.2 0.267736 0 hsa-miR-629_st −0.57916 1.5 0.00683 1 hsa-miR-3199_st 0.233721 1.2 0.395209 0 hsa-miR-190b_st −0.5809 1.5 0.002315 1 hsa-miR-32_st −0.76384 1.7 0.076709 0 hsa-miR-3200_st −0.51984 1.4 0.163318 0 hsa-miR-3201_st 0.200403 1.1 0.485845 0 hsa-miR-3202_st 0.557603 1.5 0.103653 0 hsa-miR-320a_st −0.28228 1.2 0.242213 0 hsa-miR-4289_st −0.59249 1.5 0.010417 1 hsa-miR-655_st −0.60014 1.5 0.029042 1 hsa-miR-320b_st −0.60324 1.5 0.000494 1 hsa-miR-219-5p_st −0.60391 1.5 0.026049 1 hsa-miR-323-3p_st 0.023479 1.0 0.894121 0 hsa-miR-323-5p_st 0.637984 1.6 0.061775 0 hsa-miR-323b-3p_st 0.080146 1.1 0.648082 0 hsa-miR-103-as_st −0.61739 1.5 0.00099 1 hsa-miR-424-star_st −0.61812 1.5 0.003543 1 hsa-miR-33a-star_st −0.63921 1.6 0.045775 1 hsa-miR-325_st 0.39161 1.3 0.202669 0 hsa-miR-590-3p_st −0.3489 1.3 0.223918 0 hsa-miR-328_st −1.11995 2.2 0.066768 0 hsa-miR-329_st −0.21775 1.2 0.568575 0 hsa-miR-32-star_st 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−0.59143 1.5 0.092059 0 hsa-miR-500_st −0.80128 1.7 0.001245 1 hsa-miR-320c_st −0.81423 1.8 0.005592 1 hsa-miR-875-3p_st 0.061773 1.0 0.773593 0 hsa-miR-376a_st 0.227783 1.2 0.524136 0 hsa-miR-29b-1-star_st −0.82186 1.8 0.001095 1 hsa-miR-376b_st −0.28092 1.2 0.185203 0 hsa-miR-376c_st 0.025575 1.0 0.97473 0 hsa-miR-377_st 0.048302 1.0 0.839812 0 hsa-miR-377-star_st −0.02002 1.0 0.955863 0 hsa-miR-378_st −0.13188 1.1 0.521252 0 hsa-miR-378b_st 0.277363 1.2 0.236973 0 hsa-miR-378c_st 0.200218 1.1 0.280367 0 hsa-miR-378-star_st −0.27132 1.2 0.395511 0 hsa-miR-662_st −0.83351 1.8 0.000127 1 hsa-miR-379-star_st −0.26992 1.2 0.317944 0 hsa-miR-380_st −0.26478 1.2 0.260717 0 hsa-miR-380-star_st 0.341074 1.3 0.152083 0 hsa-miR-1274b_st −0.85283 1.8 0.001466 1 hsa-miR-382_st 0.171209 1.1 0.549609 0 hsa-miR-383_st 0.561393 1.5 0.176321 0 hsa-miR-384_st −0.50449 1.4 0.132072 0 hsa-miR-126-star_st −0.44699 1.4 0.071867 0 hsa-miR-409-5p_st −0.18055 1.1 0.186087 0 hsa-miR-410_st −0.1086 1.1 0.436408 0 hsa-miR-411_st 0.231502 1.2 0.513814 0 hsa-miR-411-star_st 0.09155 1.1 0.712877 0 hsa-miR-412_st 0.292108 1.2 0.367269 0 hsa-miR-3143_st −0.22515 1.2 0.404125 0 hsa-miR-422a_st 0.090633 1.1 0.527905 0 hsa-miR-628-5p_st −0.86805 1.8 0.002935 1 hsa-miR-423-5p_st 0.302279 1.2 0.072829 0 hsa-miR-27b-star_st −0.90672 1.9 0.00456 1 hsa-miR-499-5p_st −0.90952 1.9 6.77E−05 1 hsa-miR-425_st −1.32873 2.5 0.086668 0 hsa-miR-193b_st −0.9194 1.9 0.044117 1 hsa-miR-4252_st 0.250581 1.2 0.33181 0 hsa-miR-4253_st 0.340679 1.3 0.119376 0 hsa-miR-4254_st −0.11969 1.1 0.66528 0 hsa-miR-324-3p_st −0.95255 1.9 0.00081 1 hsa-miR-4329_st −0.97187 2.0 0.001264 1 hsa-miR-1251_st −0.97729 2.0 0.002066 1 hsa-miR-4258_st 0.383606 1.3 0.359047 0 hsa-miR-1274a_st −0.99078 2.0 0.018219 1 hsa-miR-425-star_st 0.318846 1.2 0.218195 0 hsa-miR-4260_st 0.444888 1.4 0.210779 0 hsa-miR-4261_st 0.335569 1.3 0.095322 0 hsa-miR-4262_st 0.15299 1.1 0.615328 0 hsa-miR-4263_st 0.188585 1.1 0.131973 0 hsa-miR-4264_st 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hsa-miR-339-5p_st −1.05351 2.1 0.036858 1 hsa-miR-505_st −1.05709 2.1 0.047437 1 hsa-miR-4290_st 0.594214 1.5 0.103205 0 hsa-miR-200b-star_st −1.06694 2.1 0.013656 1 hsa-miR-4292_st 0.532987 1.4 0.062882 0 hsa-miR-4293_st 0.635439 1.6 0.082819 0 hsa-miR-1246_st −1.0963 2.1 0.02776 1 hsa-miR-4295_st 0.08526 1.1 0.747239 0 hsa-miR-4296_st 0.527848 1.4 0.086917 0 hsa-miR-4297_st 0.734495 1.7 0.277893 0 hsa-miR-4298_st 0.359887 1.3 0.087727 0 hsa-miR-218_st −1.09644 2.1 0.043681 1 hsa-miR-4286_st −1.11281 2.2 0.003879 1 hsa-miR-4301_st −0.61789 1.5 0.059833 0 hsa-miR-4302_st 0.250463 1.2 0.512832 0 hsa-miR-365_st −1.11673 2.2 0.001388 1 hsa-miR-4304_st 0.631283 1.5 0.15302 0 hsa-miR-4305_st −0.23412 1.2 0.176014 0 hsa-miR-4306_st 0.066563 1.0 0.696751 0 hsa-miR-26a_st −1.1466 2.2 0.012738 1 hsa-miR-4308_st −0.23737 1.2 0.293694 0 hsa-miR-4309_st −0.20677 1.2 0.06645 0 hsa-miR-186_st −1.15647 2.2 0.012007 1 hsa-miR-4310_st 0.536411 1.5 0.079085 0 hsa-miR-4311_st 0.387188 1.3 0.201073 0 hsa-miR-4312_st 0.545958 1.5 0.187312 0 hsa-miR-4313_st −0.34859 1.3 0.199382 0 hsa-miR-4314_st 0.920085 1.9 0.05435 0 hsa-miR-4315_st 0.545556 1.5 0.141582 0 hsa-miR-149_st −1.16032 2.2 0.024674 1 hsa-miR-106b-star_st −1.16247 2.2 0.016346 1 hsa-miR-4318_st 0.40804 1.3 0.101943 0 hsa-miR-4319_st 0.376405 1.3 0.162053 0 hsa-miR-29b-2-star_st −1.18536 2.3 0.002818 1 hsa-miR-432_st 0.243124 1.2 0.498705 0 hsa-miR-4320_st −0.07682 1.1 0.775095 0 hsa-miR-522_st −0.24478 1.2 0.236455 0 hsa-miR-4322_st 0.365759 1.3 0.125926 0 hsa-miR-4323_st 0.428463 1.3 0.197673 0 hsa-miR-93-star_st −1.18842 2.3 0.000519 1 hsa-miR-4325_st −0.15717 1.1 0.677045 0 hsa-miR-4326_st 0.021366 1.0 0.898117 0 hsa-miR-874_st 0.472868 1.4 0.080117 0 hsa-miR-4328_st −0.06311 1.0 0.817515 0 hsa-let-7e-star_st −1.20176 2.3 0.000898 1 hsa-miR-720_st −0.61139 1.5 0.079327 0 hsa-miR-433_st 0.478322 1.4 0.237514 0 hsa-miR-4330_st 0.738696 1.7 0.186338 0 hsa-miR-448_st −0.23906 1.2 0.626683 0 hsa-miR-449a_st −0.23688 1.2 0.273276 0 hsa-miR-449b_st 0.255343 1.2 0.384548 0 hsa-miR-1975_st −0.59647 1.5 0.068224 0 hsa-miR-449c_st 0.229738 1.2 0.578924 0 hsa-miR-449c-star_st 0.339858 1.3 0.225351 0 hsa-miR-1_st −1.21267 2.3 0.017395 1 hsa-miR-450b-3p_st −0.2953 1.2 0.205481 0 hsa-miR-450b-5p_st −0.28982 1.2 0.31888 0 hsa-miR-451_st −0.03731 1.0 0.946044 0 hsa-miR-452_st 0.291868 1.2 0.395208 0 hsa-miR-452-star_st −0.1084 1.1 0.487922 0 hsa-miR-548b-5p_st 0.293886 1.2 0.056737 0 hsa-miR-454-star_st 0.275892 1.2 0.152569 0 hsa-miR-455-3p_st −0.74169 1.7 0.175044 0 hsa-miR-455-5p_st −0.46334 1.4 0.23172 0 hsa-miR-466_st −0.0117 1.0 0.928298 0 hsa-miR-483-3p_st −0.17839 1.1 0.586027 0 hsa-miR-17_st −1.24124 2.4 0.022884 1 hsa-miR-320d_st −1.24305 2.4 0.016573 1 hsa-miR-485-3p_st 0.265894 1.2 0.573541 0 hsa-miR-485-5p_st 0.567209 1.5 0.13375 0 hsa-miR-486-3p_st 0.324086 1.3 0.181653 0 hsa-miR-486-5p_st −0.23003 1.2 0.661842 0 hsa-miR-644_st 0.080448 1.1 0.793768 0 hsa-miR-3152_st 0.881141 1.8 0.134634 0 hsa-miR-488_st −0.01991 1.0 0.920397 0 hsa-miR-488-star_st 0.069247 1.0 0.766997 0 hsa-miR-450a_st −1.24402 2.4 0.000162 1 hsa-miR-20a_st −1.24779 2.4 0.043716 1 hsa-miR-484_st −1.29519 2.5 0.024706 1 hsa-miR-491-3p_st −0.13408 1.1 0.440417 0 hsa-miR-491-5p_st 0.041577 1.0 0.846465 0 hsa-miR-197_st −1.30773 2.5 0.000409 1 hsa-miR-493_st −0.04313 1.0 0.893703 0 hsa-miR-493-star_st 0.068753 1.0 0.867647 0 hsa-miR-494_st 0.345122 1.3 0.257661 0 hsa-miR-495_st −0.28479 1.2 0.518507 0 hsa-miR-496_st −0.38173 1.3 0.192888 0 hsa-miR-497_st −0.49443 1.4 0.417865 0 hsa-miR-497-star_st −0.03322 1.0 0.874365 0 hsa-miR-498_st 0.471247 1.4 0.099652 0 hsa-miR-499-3p_st −0.1898 1.1 0.217676 0 hsa-miR-24-1-star_st −1.31849 2.5 0.005603 1 hsa-miR-340_st −1.33011 2.5 0.00583 1 hsa-miR-500b_st −0.16416 1.1 0.642732 0 hsa-miR-500-star_st 0.157403 1.1 0.271468 0 hsa-miR-501-3p_st 0.25968 1.2 0.266636 0 hsa-miR-501-5p_st −0.07301 1.1 0.492835 0 hsa-miR-502-3p_st 0.119274 1.1 0.339925 0 hsa-miR-502-5p_st 0.268249 1.2 0.330544 0 hsa-miR-503_st 0.000161 1.0 0.999156 0 hsa-miR-192_st −1.33799 2.5 0.026824 1 hsa-let-7g_st −1.34037 2.5 0.031696 1 hsa-miR-505-star_st 0.20394 1.2 0.319073 0 hsa-miR-506_st −0.27491 1.2 0.205414 0 hsa-miR-507_st −0.19228 1.1 0.316814 0 hsa-miR-508-3p_st −0.2872 1.2 0.181928 0 hsa-miR-508-5p_st 0.370544 1.3 0.16899 0 hsa-miR-509-3-5p_st 0.77745 1.7 0.106877 0 hsa-miR-509-3p_st 0.309421 1.2 0.38079 0 hsa-miR-106a_st −1.37191 2.6 0.02611 1 hsa-miR-106b_st −1.38069 2.6 0.009763 1 hsa-miR-511_st 0.122845 1.1 0.614312 0 hsa-miR-512-3p_st 0.390853 1.3 0.105227 0 hsa-miR-512-5p_st 0.660443 1.6 0.159525 0 hsa-miR-513a-3p_st −0.20092 1.1 0.5732 0 hsa-miR-23a_st −1.40296 2.6 0.016684 1 hsa-miR-25_st −1.41356 2.7 0.029964 1 hsa-miR-598_st −1.41999 2.7 0.004541 1 hsa-miR-1260_st −1.42155 2.7 0.025045 1 hsa-miR-514b-3p_st 0.079916 1.1 0.792966 0 hsa-miR-514b-5p_st 0.451744 1.4 0.056935 0 hsa-miR-515-3p_st 0.257161 1.2 0.372246 0 hsa-miR-515-5p_st −0.14137 1.1 0.551557 0 hsa-miR-516a-3p_st −0.3671 1.3 0.20403 0 hsa-miR-27a_st −1.43065 2.7 0.032296 1 hsa-miR-100_st −1.466 2.8 0.015928 1 hsa-miR-101_st −1.46742 2.8 0.047468 1 hsa-miR-517a_st −0.11374 1.1 0.729152 0 hsa-miR-517b_st −0.22637 1.2 0.296381 0 hsa-miR-517c_st −0.22077 1.2 0.390675 0 hsa-miR-517-star_st 0.286517 1.2 0.180976 0 hsa-miR-518a-3p_st 0.122831 1.1 0.509466 0 hsa-miR-518a-5p_st 0.450068 1.4 0.336769 0 hsa-miR-518b_st −0.23318 1.2 0.311518 0 hsa-miR-518c_st −0.33735 1.3 0.228688 0 hsa-miR-301a_st −1.46999 2.8 0.009301 1 hsa-miR-518d-3p_st −0.10291 1.1 0.518346 0 hsa-miR-518d-5p_st 0.229352 1.2 0.416537 0 hsa-miR-518e_st −0.35396 1.3 0.331555 0 hsa-let-7f_st −1.47955 2.8 0.023454 1 hsa-miR-518f_st −0.10237 1.1 0.667527 0 hsa-miR-1826_st −0.45843 1.4 0.151401 0 hsa-miR-519a_st −0.11837 1.1 0.694239 0 hsa-miR-519a-star_st 0.441549 1.4 0.261878 0 hsa-miR-519b-3p_st −0.47802 1.4 0.115601 0 hsa-miR-1283_st 0.019298 1.0 0.917184 0 hsa-miR-519c-3p_st −0.20606 1.2 0.37948 0 hsa-miR-519c-5p_st 0.450758 1.4 0.086822 0 hsa-miR-519d_st −0.15044 1.1 0.548921 0 hsa-miR-519e_st −0.57309 1.5 0.073961 0 hsa-miR-519e-star_st 0.818031 1.8 0.084783 0 hsa-miR-520a-3p_st 0.30561 1.2 0.167727 0 hsa-miR-1908_st −0.46528 1.4 0.146264 0 hsa-miR-520b_st −0.0826 1.1 0.785643 0 hsa-miR-520c-3p_st −0.11881 1.1 0.719481 0 hsa-miR-520c-5p_st 0.313653 1.2 0.352911 0 hsa-miR-181a-star_st −1.48692 2.8 0.014503 1 hsa-miR-21_st −1.49665 2.8 0.013004 1 hsa-miR-520e_st −0.00382 1.0 0.987061 0 hsa-miR-520f_st −0.29484 1.2 0.260527 0 hsa-miR-520g_st 0.025867 1.0 0.863878 0 hsa-miR-520h_st −0.23061 1.2 0.465788 0 hsa-miR-521_st −0.4412 1.4 0.090071 0 hsa-miR-302a-star_st 0.183684 1.1 0.370531 0 hsa-miR-886-3p_st −1.49782 2.8 0.033148 1 hsa-miR-523_st −0.23984 1.2 0.483016 0 hsa-miR-29a_st −1.5044 2.8 0.015461 1 hsa-miR-524-3p_st 0.170023 1.1 0.211849 0 hsa-miR-142-3p_st 0.255482 1.2 0.622115 0 hsa-miR-525-3p_st −0.12933 1.1 0.625719 0 hsa-miR-525-5p_st −0.07056 1.1 0.735299 0 hsa-miR-762_st −0.43808 1.4 0.165812 0 hsa-miR-423-3p_st −1.50794 2.8 0.000424 1 hsa-miR-449b-star_st 0.559689 1.5 0.178184 0 hsa-miR-527_st 0.47098 1.4 0.137194 0 hsa-miR-532-3p_st −1.01366 2.0 0.067465 0 hsa-miR-532-5p_st −0.63302 1.6 0.147815 0 hsa-miR-539_st 0.126512 1.1 0.719238 0 hsa-let-7a_st −1.54323 2.9 0.018056 1 hsa-miR-541-star_st 0.21097 1.2 0.193034 0 hsa-miR-542-3p_st 0.152322 1.1 0.591227 0 hsa-miR-542-5p_st −0.6952 1.6 0.16266 0 hsa-miR-543_st −0.42727 1.3 0.074664 0 hsa-miR-544_st −0.18347 1.1 0.623766 0 hsa-miR-544b_st 0.127209 1.1 0.603508 0 hsa-miR-545_st −0.26396 1.2 0.336005 0 hsa-miR-545-star_st −0.52642 1.4 0.128244 0 hsa-miR-548a-3p_st −0.38127 1.3 0.366102 0 hsa-miR-2861_st −0.45367 1.4 0.154287 0 hsa-miR-31_st −1.5512 2.9 0.018739 1 hsa-miR-367_st −0.18755 1.1 0.478768 0 hsa-miR-548c-3p_st −0.59016 1.5 0.249024 0 hsa-miR-548c-5p_st 0.165415 1.1 0.824566 0 hsa-miR-548d-3p_st −0.15575 1.1 0.462901 0 hsa-miR-548d-5p_st −0.17104 1.1 0.702449 0 hsa-miR-548e_st −0.0759 1.1 0.824529 0 hsa-miR-548f_st −0.47056 1.4 0.174292 0 hsa-miR-548g_st −0.56438 1.5 0.245965 0 hsa-miR-548h_st −0.3003 1.2 0.177204 0 hsa-miR-548i_st 0.078643 1.1 0.734091 0 hsa-miR-548j_st 0.25418 1.2 0.318076 0 hsa-miR-548k_st −0.21967 1.2 0.084338 0 hsa-miR-526b-star_st −0.12919 1.1 0.707069 0 hsa-miR-548m_st 0.066115 1.0 0.792698 0 hsa-miR-548n_st −0.17766 1.1 0.567752 0 hsa-miR-548o_st −0.25402 1.2 0.360821 0 hsa-miR-548p_st −0.17622 1.1 0.446389 0 hsa-miR-548q_st 0.71986 1.6 0.067832 0 hsa-miR-548s_st −0.06254 1.0 0.708593 0 hsa-miR-548t_st 0.191443 1.1 0.496084 0 hsa-miR-548u_st −0.6602 1.6 0.106665 0 hsa-miR-638_st −0.50391 1.4 0.122174 0 hsa-miR-548w_st −0.07509 1.1 0.874394 0 hsa-miR-3119_st 0.023444 1.0 0.945048 0 hsa-miR-549_st 0.008477 1.0 0.973793 0 hsa-miR-205_st −1.55979 2.9 0.037086 1 hsa-miR-550-star_st −0.08505 1.1 0.623248 0 hsa-miR-551a_st 0.25166 1.2 0.39002 0 hsa-miR-93_st −1.56661 3.0 0.025987 1 hsa-miR-551b-star_st −0.25958 1.2 0.150179 0 hsa-let-7d-star_st −1.57161 3.0   1E−06 1 hsa-miR-553_st −0.35993 1.3 0.190737 0 hsa-miR-554_st 0.096033 1.1 0.7478 0 hsa-miR-555_st −0.06063 1.0 0.724188 0 hsa-miR-556-3p_st −0.06018 1.0 0.827136 0 hsa-miR-556-5p_st −0.59567 1.5 0.13322 0 hsa-miR-557_st 0.440682 1.4 0.085371 0 hsa-miR-558_st −0.38111 1.3 0.376246 0 hsa-miR-559_st −0.24743 1.2 0.451607 0 hsa-miR-561_st −0.37003 1.3 0.2507 0 hsa-miR-562_st −0.42219 1.3 0.171043 0 hsa-miR-563_st −0.07291 1.1 0.646014 0 hsa-miR-361-5p_st −1.5803 3.0 0.004489 1 hsa-miR-566_st 0.24973 1.2 0.206058 0 hsa-miR-567_st 0.210488 1.2 0.288931 0 hsa-miR-568_st −0.43354 1.4 0.155504 0 hsa-miR-29c_st −1.61118 3.1 0.008279 1 hsa-miR-570_st −0.15191 1.1 0.656083 0 hsa-miR-571_st −0.25703 1.2 0.232749 0 hsa-miR-572_st 0.30286 1.2 0.275827 0 hsa-miR-573_st −0.12504 1.1 0.60286 0 hsa-miR-132_st −1.61895 3.1 0.006005 1 hsa-miR-574-5p_st 0.102743 1.1 0.37019 0 hsa-let-7d_st −1.62762 3.1 0.017634 1 hsa-miR-576-3p_st 0.006569 1.0 0.976898 0 hsa-miR-576-5p_st 0.324087 1.3 0.303538 0 hsa-miR-577_st −0.05216 1.0 0.863778 0 hsa-miR-578_st −0.41059 1.3 0.113335 0 hsa-miR-579_st −0.30904 1.2 0.111718 0 hsa-miR-580_st −0.36563 1.3 0.289385 0 hsa-miR-191_st −1.63421 3.1 0.020089 1 hsa-miR-582-3p_st −0.01156 1.0 0.967935 0 hsa-miR-582-5p_st 0.751847 1.7 0.242341 0 hsa-miR-1915_st −0.5001 1.4 0.124304 0 hsa-let-7c_st −1.66897 3.2 0.012062 1 hsa-miR-585_st −0.05951 1.0 0.815908 0 hsa-miR-586_st −0.12226 1.1 0.630922 0 hsa-miR-324-5p_st −1.67397 3.2 0.000385 1 hsa-miR-588_st 0.266646 1.2 0.265895 0 hsa-miR-589_st 0.051192 1.0 0.85737 0 hsa-miR-589-star_st 0.12791 1.1 0.576093 0 hsa-miR-188-5p_st 0.414976 1.3 0.223638 0 hsa-miR-103_st −1.6799 3.2 0.0199 1 hsa-miR-591_st 0.246684 1.2 0.479477 0 hsa-miR-592_st −0.35004 1.3 0.126418 0 hsa-miR-593_st 0.279291 1.2 0.366004 0 hsa-miR-23b_st −1.67999 3.2 0.009157 1 hsa-miR-595_st 0.221336 1.2 0.407849 0 hsa-miR-99a_st −1.7069 3.3 0.015518 1 hsa-miR-15b_st −1.7135 3.3 0.007437 1 hsa-miR-135b_st −1.72432 3.3 0.00367 1 hsa-miR-599_st −0.39735 1.3 0.202803 0 hsa-miR-600_st −0.42431 1.3 0.262063 0 hsa-miR-107_st −1.7247 3.3 0.017993 1 hsa-miR-602_st 0.244492 1.2 0.244548 0 hsa-miR-603_st −0.35019 1.3 0.287249 0 hsa-miR-3065-5p_st −1.7278 3.3   2E−05 1 hsa-miR-605_st 0.654207 1.6 0.241571 0 hsa-miR-24_st −1.73165 3.3 0.012912 1 hsa-miR-607_st −0.38094 1.3 0.230152 0 hsa-miR-608_st 0.399753 1.3 0.214128 0 hsa-miR-609_st −0.01148 1.0 0.971304 0 hsa-miR-3196_st −0.51976 1.4 0.113395 0 hsa-miR-26b_st −1.74563 3.4 0.010462 1 hsa-miR-28-5p_st −1.81666 3.5 0.015131 1 hsa-miR-613_st 0.463317 1.4 0.168306 0 hsa-miR-338-3p_st −1.83368 3.6 0.000214 1 hsa-miR-615-3p_st 0.518109 1.4 0.19134 0 hsa-miR-454_st −1.84034 3.6 0.004066 1 hsa-miR-616_st 0.26552 1.2 0.445685 0 hsa-miR-151-5p_st −1.8621 3.6 0.016985 1 hsa-miR-617_st 0.69404 1.6 0.261134 0 hsa-miR-128_st −1.88819 3.7 0.018707 1 hsa-miR-619_st 0.153134 1.1 0.362526 0 hsa-miR-620_st 0.109661 1.1 0.564687 0 hsa-miR-621_st −0.45683 1.4 0.145843 0 hsa-let-7b_st −1.93383 3.8 0.004097 1 hsa-miR-623_st 0.312316 1.2 0.305791 0 hsa-miR-624_st −0.38213 1.3 0.118097 0 hsa-miR-624-star_st −0.36289 1.3 0.171384 0 hsa-miR-183_st −1.93409 3.8 0.006078 1 hsa-miR-30b_st −1.97702 3.9 0.018453 1 hsa-miR-626_st −0.10175 1.1 0.547901 0 hsa-miR-627_st −0.35975 1.3 0.21916 0 hsa-miR-628-3p_st 0.714063 1.6 0.052801 0 hsa-miR-31-star_st −1.97746 3.9 0.025758 1 hsa-miR-218-1-star_st 0.171178 1.1 0.317876 0 hsa-miR-629-star_st −0.12576 1.1 0.678675 0 hsa-miR-630_st 0.956088 1.9 0.093918 0 hsa-miR-631_st 0.751588 1.7 0.110098 0 hsa-miR-632_st 0.169891 1.1 0.666667 0 hsa-miR-633_st −0.23553 1.2 0.253977 0 hsa-miR-634_st 0.363455 1.3 0.294704 0 hsa-miR-635_st 0.413661 1.3 0.18374 0 hsa-miR-203_st −2.00197 4.0 0.008637 1 hsa-miR-331-3p_st −2.00221 4.0 0.017173 1 hsa-miR-125b_st −2.0088 4.0 0.001535 1 hsa-let-7i_st −2.01069 4.0 0.010629 1 hsa-miR-640_st 0.36472 1.3 0.367639 0 hsa-miR-641_st 0.112934 1.1 0.689435 0 hsa-miR-642_st −0.10501 1.1 0.495134 0 hsa-miR-29b_st −2.03746 4.1 0.003653 1 hsa-miR-122_st 0.260995 1.2 0.404904 0 hsa-miR-645_st 0.442712 1.4 0.222791 0 hsa-miR-646_st −0.10513 1.1 0.592753 0 hsa-miR-647_st 0.116209 1.1 0.45229 0 hsa-miR-648_st 0.517924 1.4 0.098509 0 hsa-miR-649_st 0.427329 1.3 0.242068 0 hsa-miR-182_st −2.05592 4.2 0.039156 1 hsa-miR-651_st 0.136891 1.1 0.211866 0 hsa-miR-652_st −0.29319 1.2 0.39282 0 hsa-miR-653_st −0.17913 1.1 0.502094 0 hsa-miR-654-3p_st −0.09408 1.1 0.806228 0 hsa-miR-374b_st −2.06484 4.2 0.013714 1 hsa-miR-130a_st −2.07106 4.2 0.001563 1 hsa-miR-656_st −0.18179 1.1 0.453615 0 hsa-miR-657_st 0.524405 1.4 0.078783 0 hsa-miR-658_st 0.396407 1.3 0.053112 0 hsa-miR-99b_st −2.07354 4.2 0.003615 1 hsa-miR-660_st −1.00935 2.0 0.177414 0 hsa-miR-661_st 0.556038 1.5 0.211682 0 hsa-miR-30e-star_st −2.07466 4.2 0.02214 1 hsa-miR-663_st −0.19822 1.1 0.492136 0 hsa-miR-663b_st 0.683826 1.6 0.059632 0 hsa-miR-664_st −0.67316 1.6 0.315716 0 hsa-miR-664-star_st 0.238579 1.2 0.646885 0 hsa-miR-30d_st −2.07642 4.2 0.016353 1 hsa-miR-668_st 0.58339 1.5 0.221596 0 hsa-miR-670_st 0.401209 1.3 0.371453 0 hsa-miR-671-3p_st 0.278112 1.2 0.086159 0 hsa-miR-671-5p_st 0.503639 1.4 0.066593 0 hsa-miR-30a-star_st −2.08511 4.2 0.031655 1 hsa-miR-675-star_st −0.04357 1.0 0.766069 0 hsa-miR-148b_st −2.09371 4.3 0.030988 1 hsa-miR-708_st −0.54092 1.5 0.179872 0 hsa-miR-708-star_st −0.13177 1.1 0.651749 0 hsa-miR-221-star_st −2.10599 4.3 0.001863 1 hsa-let-7e_st −2.12879 4.4 0.01363 1 hsa-miR-7-1-star_st −0.59785 1.5 0.198372 0 hsa-miR-27b_st −2.1404 4.4 0.020858 1 hsa-miR-34a_st −2.16416 4.5 0.016747 1 hsa-miR-744_st 0.385006 1.3 0.068587 0 hsa-miR-744-star_st −0.05725 1.0 0.788584 0 hsa-miR-92b_st −2.18683 4.6 9.76E−05 1 hsa-miR-759_st −0.24225 1.2 0.329115 0 hsa-miR-760_st 0.37276 1.3 0.074669 0 hsa-miR-92a_st −2.2569 4.8 0.001851 1 hsa-miR-335_st −2.27502 4.8 0.010623 1 hsa-miR-96_st −2.27634 4.8 0.038554 1 hsa-miR-95_st −2.31054 5.0 0.007726 1 hsa-miR-766_st 0.932585 1.9 0.149437 0 hsa-miR-767-3p_st −0.01512 1.0 0.946471 0 hsa-miR-767-5p_st −0.00328 1.0 0.990581 0 hsa-miR-98_st −2.31096 5.0 0.015734 1 hsa-miR-769-5p_st −0.17583 1.1 0.480561 0 hsa-miR-770-5p_st 0.212152 1.2 0.561233 0 hsa-miR-802_st −0.18983 1.1 0.471489 0 hsa-miR-34b-star_st −2.33393 5.0 0.013135 1 hsa-miR-581_st 0.038637 1.0 0.929187 0 hsa-miR-181d_st −2.38781 5.2 5.43E−05 1 hsa-miR-875-5p_st −0.24512 1.2 0.437978 0 hsa-miR-876-3p_st 0.301243 1.2 0.272646 0 hsa-miR-876-5p_st −0.34164 1.3 0.218447 0 hsa-miR-151-3p_st −2.39852 5.3 0.010408 1 hsa-miR-877-star_st 0.85547 1.8 0.061317 0 hsa-miR-885-3p_st 0.184839 1.1 0.377934 0 hsa-miR-200c_st −2.41315 5.3 0.007772 1 hsa-miR-429_st −2.49862 5.7 0.000779 1 hsa-miR-886-5p_st −0.31579 1.2 0.086841 0 hsa-miR-224_st −2.57625 6.0 6.34E−07 1 hsa-miR-888_st 0.138689 1.1 0.585938 0 hsa-miR-4321_st 0.775601 1.7 0.052804 0 hsa-miR-889_st 0.118195 1.1 0.560606 0 hsa-miR-181b_st −2.58165 6.0 4.34E−07 1 hsa-miR-891a_st 0.218514 1.2 0.431066 0 hsa-miR-891b_st −0.55826 1.5 0.078082 0 hsa-miR-892a_st 0.344266 1.3 0.472797 0 hsa-miR-892b_st 0.226274 1.2 0.458406 0 hsa-miR-9_st −0.09564 1.1 0.811743 0 hsa-miR-222_st −2.59688 6.0 0.000732 1 hsa-miR-141_st −2.59852 6.1 0.002638 1 hsa-miR-221_st −2.70452 6.5 0.001066 1 hsa-miR-924_st 0.07618 1.1 0.622376 0 hsa-miR-181a_st −2.74062 6.7 0.000111 1 hsa-miR-181c_st −2.77321 6.8 0.00094 1 hsa-miR-4324_st −2.7793 6.9 0.000579 1 hsa-miR-125a-5p_st −2.78675 6.9 0.000273 1 hsa-miR-92b-star_st 0.161865 1.1 0.441506 0 hsa-miR-3195_st 0.545451 1.5 0.105432 0 hsa-miR-3137_st 0.714678 1.6 0.13027 0 hsa-miR-934_st −0.10872 1.1 0.733275 0 hsa-miR-935_st −0.26142 1.2 0.554128 0 hsa-miR-551b_st −2.9308 7.6 2.75E−08 1 hsa-miR-937_st 0.433089 1.4 0.171528 0 hsa-miR-938_st 0.206369 1.2 0.57125 0 hsa-miR-939_st 0.428522 1.3 0.123188 0 hsa-miR-7-2-star_st −0.63671 1.6 0.202747 0 hsa-miR-146b-5p_st −3.07337 8.4 0.000759 1 hsa-miR-941_st −0.02729 1.0 0.920459 0 hsa-miR-942_st −0.15221 1.1 0.584159 0 hsa-miR-200a_st −3.20855 9.2 0.001744 1 hsa-miR-944_st −0.38554 1.3 0.210878 0 hsa-miR-7_st −0.95705 1.9 0.213978 0 hsa-miR-375_st −3.22767 9.4 5.75E−10 1 hsa-miR-96-star_st −0.07371 1.1 0.531711 0 hsa-miR-424_st −3.28988 9.8 0.001702 1 hsa-miR-181a-2-star_st −3.36316 10.3 0.001188 1 hsa-miR-200b_st −3.59322 12.1 0.004911 1 hsa-miR-146b-3p_st −3.7959 13.9 3.15E−08 1 hsa-miR-99b-star_st −0.20555 1.2 0.24171 0 hsa-miR-9-star_st 0.757846 1.7 0.054881 0

TABLE O  List of miRNAs SEQ Alternate  ID miR Name Name Sequence NO: miR-375 miR-375 UUUGUUCGUUCGGCUCGCGUGA 13 miR-7 miR-7-5p UGGAAGACUAGUGAUUUUGUUGU 2 miR-15a miR-15a-5p UAGCAGCACAUAAUGGUUUGUG 36 miR-19b miR49b-3p UGUGCAAAUCCAUGCAAAACUGA 90 miR-21 miR-21-5p UAGCUUAUCAGACUGAUGUUGA 22 miR-29b miR-29b-3p UAGCUUAUCAGACUGAUGUUGA 139 miR-29b- miR-29b-1-5p GCUGGUUUCAUAUGGUGGUUUAGA 138 1* miR-31 miR-31-5p AGGCAAGAUGCUGGCAUAGCU 18 miR-31* miR-31-3p UGCUAUGCCAACAUAUUGCCAU 41 miR-34a miR-34a-5p UGGCAGUGUCUUAGCUGGUUGU 23 miR-34a* miR-34a-3p CAAUCAGCAAGUAUACUGCCCU 42 miR-34b* miR-34b-5p UAGGCAGUGUCAUUAGCUGAUUG 43 miR-96 r6R-96-5p UUUGLXACUAGCACAUUUUUGCU 129 miR-138- miR-138-1-3p GCUACUUCACAACACCAGGGCC 24 1* miR-139- miR-139-5p UCUACAGUGCACGUGUCUCCAG 25 5p miR-141 miR-141-3p UAACACUGUCUGGUAAAGAUGG 26 miR-146b- miR-146b-3p UGCCCUGUGGACUCAGUUCUGG 4 3p miR-146b- miR-14611-5p UGAGAACUGAAUUCCAUAGGCU 3 5p miR-151- miR-151a-3p CUAGACUGAAGCUCCUUGAGG 388 3p miR-155 miR-155-5p UUAAUGCUAAUCGUGAUAGGGGU 28 miR-181a- miR-181a-2-3p ACCACUGACCGUUGACUGUACC 178 2* miR-197 miR-197-3p UUCACCACCUUCUCCACCCAGC 30 miR-204 miR-204-5p UUCCCUUUGUCAUCCUAUGCCU 192 miR-221 miR-221-3p AGCUACAUUGUCUGCUGGGUUUC 17 miR-221* miR-221-5p ACCUGGcAUACAAUGUAGAUUU 7 miR-222 miR-222-3p AGCUACAVCUGGCUACUGGGU 31 miR-328 miR-328 CUGGCCCUCUCUGCCCUUCCGU 379 miR-424 miR-424-5p CAGCAGCAAUUCAUGUUUUGAA 413 miR-551b miR-551b-3p GCGACCCAUACUUGGUUUCAG 54

REFERENCES

The following references, to the extent that they provide exemplary procedural or other details supplementary to those set forth herein, are specifically incorporated herein by reference.

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1-219. (canceled)
 220. A method of treating a patient with a malignant thyroid tumor, the method comprising: a) amplifying nucleic molecules from a patient thyroid sample; b) measuring the level of expression in the thyroid sample of a group of microRNA selected from the group consisting of: miRNAs: miR-375, miR-146b-5p, miR-204-5p, miR-7-5p, and miR-141-3p; c) comparing the level of expression of each biomarker miRNA measured in a) to the level of expression of another biomarker miRNA measured in a), wherein mir-375 is compared to the level of expression of miR-7-5p, miR-204-5p, or miR-141-3p, or wherein miR-146b-5p is compared to the level of expression of miR-7-5p, miR-204-5p, or miR-141-3p; c) calculating a diagnostic score implemented by a computer that indicates the probability that the thyroid sample is malignant, wherein the diagnostic score is based on one or more of the comparisons in b), wherein the sample is identified as malignant if the probability indicates the thyroid sample is malignant; and treating the patient identified to have a malignant thyroid sample by administering radioactive iodine, radiation, chemotherapy to the patient identified to have a malignant thyroid sample or performing a full or partial thyroidectomy on the patient identified to have a malignant thyroid sample.
 221. The method of claim 220, wherein the thyroid sample is a cystic fluid sample.
 222. The method of claim 220, wherein the thyroid sample is a fine need aspirate sample.
 223. The method of claim 220, wherein the diagnostic score is calculated using weighted coefficients for each of the measured expression levels of biomarker miRNAs.
 224. The method of claim 220, wherein the diagnostic score identifies the thyroid sample as malignant when the expression level of at least one measured miRNA is increased in a malignant thyroid sample relative to the expression level of a benign thyroid sample and the expression level of at least a second measured miRNA is decreased in a malignant thyroid sample relative to the expression level of a benign thyroid sample, wherein the increased miRNA is miR-141-3p, miR-146b-5p, or miR-375 and the decreased miRNA is miR-7-5p or miR-205-5p.
 225. The method of claim 220, further comprising generating a malignant data set and a benign data set using logistic regression model and fitting the diagnostic score into either the malignant data set or the benign data set, wherein the diagnostic score that fits in the malignant data set is identified as a malignant thyroid sample or the diagnostic score that fits in the benign data set is identified as a benign thyroid sample.
 226. The method of claim 220, wherein the treating comprises administering radioactive iodine to the patient identified to have a malignant thyroid sample.
 227. The method of claim 220, wherein the treating comprises administering radiation to the patient identified to have a malignant thyroid sample.
 228. The method of claim 220, wherein the treating comprises administering chemotherapy to the patient identified to have a malignant thyroid sample.
 229. The method of claim 220, wherein the treating comprises performing a partial thyroidectomy on the patient identified to have a malignant thyroid sample.
 230. The method of claim 220, wherein the treating comprises performing a full thyroidectomy on the patient identified to have a malignant thyroid sample.
 231. A method of producing a labeled set of nucleic acid molecules, the method comprising: a) amplifying nucleic molecules from a patient thyroid sample; and b) labeling a group of microRNA molecules selected from the group consisting of: miRNAs: miR-375, miR-146b-5p, miR-204-5p, miR-7-5p, and miR-141-3p.
 232. The method of claim 231, wherein the label is a fluorescent label.
 234. The method of claim 231, wherein the amplifying step labels the group of microRNA.
 235. The method of claim 231, wherein the amplifying step comprises contacting the sample with labeled primers.
 236. The method of claim 235, wherein the labeled primers are fluorescent labeled primers. 